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O75592

- MYCB2_HUMAN

UniProt

O75592 - MYCB2_HUMAN

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Protein

E3 ubiquitin-protein ligase MYCBP2

Gene

MYCBP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of TSC2/tuberin. Interacts with the E2 enzymes UBE2D1, UBE2D3 and UBE2L3 (in vitro). May function as a facilitator or regulator of transcriptional activation by MYC. May have a role during synaptogenesis.1 Publication

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri4390 – 444152RING-type; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri4544 – 459451B box-typeAdd
BLAST

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. ubiquitin-protein transferase activity Source: InterPro
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. branchiomotor neuron axon guidance Source: Ensembl
  2. central nervous system projection neuron axonogenesis Source: Ensembl
  3. negative regulation of protein catabolic process Source: Ensembl
  4. regulation of cytoskeleton organization Source: Ensembl
  5. regulation of protein localization Source: Ensembl
  6. regulation of transcription, DNA-templated Source: UniProtKB-KW
  7. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Transcription, Transcription regulation, Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase MYCBP2 (EC:6.3.2.-)
Alternative name(s):
Myc-binding protein 2
Pam/highwire/rpm-1 protein
Protein associated with Myc
Gene namesi
Name:MYCBP2Imported
Synonyms:KIAA0916Imported, PAM1 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:23386. MYCBP2.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. axon Source: Ensembl
  2. membrane Source: UniProtKB
  3. microtubule cytoskeleton Source: Ensembl
  4. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134871126.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 46404640E3 ubiquitin-protein ligase MYCBP2PRO_0000055963Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei140 – 1401Phosphoserine1 Publication
Modified residuei143 – 1431Phosphoserine1 Publication
Modified residuei145 – 1451Phosphoserine1 Publication
Disulfide bondi1710 ↔ 1825By similarity
Modified residuei2645 – 26451Phosphothreonine3 Publications
Modified residuei2751 – 27511Phosphoserine1 Publication
Modified residuei2882 – 28821Phosphoserine1 Publication
Modified residuei3052 – 30521Phosphoserine1 Publication
Modified residuei3440 – 34401Phosphoserine1 Publication
Modified residuei3467 – 34671Phosphoserine5 Publications

Post-translational modificationi

Autoubiquitinated.1 Publication

Keywords - PTMi

Disulfide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiO75592.
PaxDbiO75592.
PRIDEiO75592.

PTM databases

PhosphoSiteiO75592.

Expressioni

Tissue specificityi

Expressed in all tissues examined, expression is exceptionally abundant in brain and thymus. Colocalizes with TSC1 and TSC2 along the neurites and in the growth cones. Colocalized with TSC1 in one of the filopodial extensions at the tip of a growth cone.1 Publication

Gene expression databases

BgeeiO75592.
CleanExiHS_MYCBP2.
HS_PAM.
ExpressionAtlasiO75592. baseline and differential.
GenevestigatoriO75592.

Organism-specific databases

HPAiHPA039945.

Interactioni

Subunit structurei

Interacts with MYC. Interacts with TSC2 (tuberin) when TSC2 is in complex with TSC1 (hamartin). Interacts with FBXO45.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Q99IB83EBI-1043774,EBI-6927928From a different organism.
Rae1Q3SWS82EBI-1043774,EBI-6920222From a different organism.

Protein-protein interaction databases

BioGridi116709. 34 interactions.
DIPiDIP-28142N.
IntActiO75592. 35 interactions.
MINTiMINT-1632199.
STRINGi9606.ENSP00000349892.

Structurei

3D structure databases

ProteinModelPortaliO75592.
SMRiO75592. Positions 496-677, 880-986, 1189-1349, 1688-1847, 2330-2356.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati562 – 61756RCC1 1Sequence AnalysisAdd
BLAST
Repeati661 – 71757RCC1 2Sequence AnalysisAdd
BLAST
Repeati869 – 91951RCC1 3Sequence AnalysisAdd
BLAST
Repeati920 – 97051RCC1 4Sequence AnalysisAdd
BLAST
Repeati972 – 102857RCC1 5Sequence AnalysisAdd
BLAST
Repeati2303 – 2405103FilaminSequence AnalysisAdd
BLAST
Domaini3681 – 3859179DOCPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1197 – 1348152PHR domain 1By similarityAdd
BLAST
Regioni1688 – 1846159PHR domain 2By similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi65 – 8824Lys-richSequence AnalysisAdd
BLAST
Compositional biasi728 – 77649Cys-richSequence AnalysisAdd
BLAST
Compositional biasi2682 – 2806125Ser-richSequence AnalysisAdd
BLAST
Compositional biasi3156 – 317722Lys-richSequence AnalysisAdd
BLAST
Compositional biasi3224 – 325532Gly-richAdd
BLAST

Domaini

The PHR domains are compact beta-sandwich folds composed of 11 antiparallel strands and decorated with conserved apical loops. They are likely to play a structural role and mediate interactions with substrates or partners (By similarity).By similarity

Sequence similaritiesi

Belongs to the highwire family.Curated
Contains 1 B box-type zinc finger.Sequence Analysis
Contains 1 DOC domain.PROSITE-ProRule annotation
Contains 1 filamin repeat.PROSITE-ProRule annotation
Contains 5 RCC1 repeats.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri4390 – 444152RING-type; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri4544 – 459451B box-typeAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG240798.
GeneTreeiENSGT00390000011403.
HOVERGENiHBG053153.
InParanoidiO75592.
KOiK10693.
OrthoDBiEOG75B84C.
PhylomeDBiO75592.
TreeFamiTF313151.

Family and domain databases

Gene3Di2.130.10.30. 2 hits.
2.60.120.260. 1 hit.
2.60.40.10. 2 hits.
3.30.40.10. 1 hit.
InterProiIPR004939. APC_su10/DOC_dom.
IPR017868. Filamin/ABP280_repeat-like.
IPR008979. Galactose-bd-like.
IPR027047. Highwire/Pam/Rpm-1.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR012983. PHR.
IPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
IPR003646. SH3-like_bac-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR12846:SF14. PTHR12846:SF14. 1 hit.
PfamiPF00630. Filamin. 1 hit.
PF08005. PHR. 2 hits.
PF00415. RCC1. 1 hit.
PF08239. SH3_3. 1 hit.
PF13639. zf-RING_2. 1 hit.
[Graphical view]
PRINTSiPR00633. RCCNDNSATION.
SMARTiSM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF50985. SSF50985. 2 hits.
SSF81296. SSF81296. 2 hits.
PROSITEiPS51284. DOC. 1 hit.
PS50194. FILAMIN_REPEAT. 1 hit.
PS00626. RCC1_2. 2 hits.
PS50012. RCC1_3. 3 hits.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 11 Publication (identifier: O75592-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPVPDGSVAA AGLGLGLPAA DSRGHYQLLL SGRALADRYR RIYTAALNDR
60 70 80 90 100
DQGGGSAGHP ASRNKKILNK KKLKRKQKSK SKVKTRSKSE NLENTVIIPD
110 120 130 140 150
IKLHSNPSAF NIYCNVRHCV LEWQKKEISL AAASKNSVQS GESDSDEEEE
160 170 180 190 200
SKEPPIKLPK IIEVGLCEVF ELIKETRFSH PSLCLRSLQA LLNVLQGQQP
210 220 230 240 250
EGLQSEPPEV LESLFQLLLE ITVRSTGMND STGQSLTALS CACLFSLVAS
260 270 280 290 300
WGETGRTLQA ISAILTNNGS HACQTIQVPT ILNSLQRSVQ AVLVGKIQIQ
310 320 330 340 350
DWFSNGIKKA ALMHKWPLKE ISVDEDDQCL LQNDGFFLYL LCKDGLYKIG
360 370 380 390 400
SGYSGTVRGH IYNSTSRIRN RKEKKSWLGY AQGYLLYRDV NNHSMTAIRI
410 420 430 440 450
SPETLEQDGT VMLPDCHTEG QNILFTDGEY INQIAASRDD GFVVRIFATS
460 470 480 490 500
TEPVLQQELQ LKLARKCLHA CGISLFDLEK DLHIISTGFD EESAILGAGR
510 520 530 540 550
EFALMKTANG KIYYTGKYQS LGIKQGGPSA GKWVELPITK SPKIVHFSVG
560 570 580 590 600
HDGSHALLVA EDGSIFFTGS ASKGEDGEST KSRRQSKPYK PKKIIKMEGK
610 620 630 640 650
IVVYTACNNG SSSVISKDGE LYMFGKDAIY SDSSSLVTDL KGHFVTQVAM
660 670 680 690 700
GKAHTCVLMK NGEVWTFGVN NKGQCGRDTG AMNQGGKGFG VENMATAMDE
710 720 730 740 750
DLEEELDEKD EKSMMCPPGM HKWKLEQCMV CTVCGDCTGY GASCVSSGRP
760 770 780 790 800
DRVPGGICGC GSGESGCAVC GCCKACAREL DGQEARQRGI LDAVKEMIPL
810 820 830 840 850
DLLLAVPVPG VNIEEHLQLR QEEKRQRVIR RHRLEEGRGP LVFAGPIFMN
860 870 880 890 900
HREQALARLR SHPAQLKHKR DKHKDGSGER GEKDASKITT YPPGSVRFDC
910 920 930 940 950
ELRAVQVSCG FHHSVVLMEN GDVYTFGYGQ HGQLGHGDVN SRGCPTLVQA
960 970 980 990 1000
LPGPSTQVTA GSNHTAVLLM DGQVFTFGSF SKGQLGRPIL DVPYWNAKPA
1010 1020 1030 1040 1050
PMPNIGSKYG RKATWIGASG DQTFLRIDEA LINSHVLATS EIFASKHIIG
1060 1070 1080 1090 1100
LVPASISEPP PFKCLLINKV DGSCKTFNDS EQEDLQGFGV CLDPVYDVIW
1110 1120 1130 1140 1150
RFRPNTRELW CYNAVVADAR LPSAADMQSR CSILSPELAL PTGSRALTTR
1160 1170 1180 1190 1200
SHAALHILGC LDTLAAMQDL KMGVASTEEE TQAVMKVYSK EDYSVVNRFE
1210 1220 1230 1240 1250
SHGGGWGYSA HSVEAIRFSA DTDILLGGLG LFGGRGEYTA KIKLFELGPD
1260 1270 1280 1290 1300
GGDHETDGDL LAETDVLAYD CAAREKYAMM FDEPVLLQAG WWYVAWARVS
1310 1320 1330 1340 1350
GPSSDCGSHG QASITTDDGV VFQFKSSKKS NNGTDVNAGQ IPQLLYRLPT
1360 1370 1380 1390 1400
SDGSASKGKQ QTSEPVHILK RSFARTVSVE CFESLLSILH WSWTTLVLGV
1410 1420 1430 1440 1450
EELRGLKGFQ FTATLLDLER LRFVGTCCLR LLRVYTCEIY PVSATGKAVV
1460 1470 1480 1490 1500
EETSKLAECI GKTRTLLRKI LSEGVDHCMV KLDNDPQGYL SQPLSLLEAV
1510 1520 1530 1540 1550
LQECHNTFTA CFHSFYPTPA LQWACLCDLL NCLDQDIQEA NFKTSSSRLL
1560 1570 1580 1590 1600
AAVMSALCHT SVKLTSIFPI AYDGEVLLRS IVKQVSTEND STLVHRFPLL
1610 1620 1630 1640 1650
VAHMEKLSQS EENISGMTSF REVLEKMLVI VVLPVRNSLR RENELFSSHL
1660 1670 1680 1690 1700
VSNTCGLLAS IVSELTASAL GSEVDGLNSL HSVKASANRF TKTSQGRSWN
1710 1720 1730 1740 1750
TGNGSPDAIC FSVDKPGIVV VGFSVYGGGG IHEYELEVLV DDSEHAGDST
1760 1770 1780 1790 1800
HSHRWTSLEL VKGTYTTDDS PSDIAEIRLD KVVPLKENVK YAVRLRNYGS
1810 1820 1830 1840 1850
RTANGDGGMT TVQCPDGVTF TFSTCSLSSN GTNQTRGQIP QILYYRSEFD
1860 1870 1880 1890 1900
GDLQSQLLSK ANEEDKNCSR ALSVVSTVVR ASKDLLHRAL AVDADDIPEL
1910 1920 1930 1940 1950
LSSSSLFSML LPLIIAYIGP VAAAIPKVAV EVFGLVQQLL PSVAILNQKY
1960 1970 1980 1990 2000
APPAFNPNQS TDSTTGNQPE QGLSACTTSS HYAVIESEHP YKPACVMHYK
2010 2020 2030 2040 2050
VTFPECVRWM TIEFDPQCGT AQSEDVLRLL IPVRTVQNSG YGPKLTSVHE
2060 2070 2080 2090 2100
NLNSWIELKK FSGSSGWPTM VLVLPGNEAL FSLETASDYV KDDKASFYGF
2110 2120 2130 2140 2150
KCFAIGYEFS PGPDEGVIQL EKELANLGGV CAAALMKKDL ALPIGNELEE
2160 2170 2180 2190 2200
DLEILEEAAL QVCKTHSGIL GKGLALSHSP TILEALEGNL PLQIQSNEQS
2210 2220 2230 2240 2250
FLDDFIACVP GSSGGRLARW LQPDSYADPQ KTSLILNKDD IRCGWPTTIT
2260 2270 2280 2290 2300
VQTKDQYGDV VHVPNMKVEV KAVPVSQKKM SLQQDQAKKP QRIPGSPAVT
2310 2320 2330 2340 2350
AASSNTDMTY GGLASPKLDV SYEPMIVKEA RYIAITMMKV YENYSFEELR
2360 2370 2380 2390 2400
FASPTPKRPS ENMLIRVNND GTYCANWTPG AIGLYTLHVT IDGIEIDAGL
2410 2420 2430 2440 2450
EVKVKDPPKG MIPPGTQLVK PKSEPQPNKV RKFVAKDSAG LRIRSHPSLQ
2460 2470 2480 2490 2500
SEQIGIVKVN GTITFIDEIH NDDGVWLRLN DETIKKYVPN MNGYTEAWCL
2510 2520 2530 2540 2550
SFNQHLGKSL LVPVDESKTN TDDFFKDINS CCPQEATMQE QDMPFLRGGP
2560 2570 2580 2590 2600
GMYKVVKTGP SGHNIRSCPN LRGIPIGMLV LGNKVKAVGE VTNSEGTWVQ
2610 2620 2630 2640 2650
LDQNSMVEFC ESDEGEAWSL ARDRGGNQYL RHEDEQALLD QNSQTPPPSP
2660 2670 2680 2690 2700
FSVQAFNKGA SCSAQGFDYG LGNSKGDRGN ISTSSKPAST SGKSELSSKH
2710 2720 2730 2740 2750
SRSLKPDGRM SRTTADQKKP RGTESLSASE SLILKSDAAK LRSDSHSRSL
2760 2770 2780 2790 2800
SPNHNTLQTL KSDGRMPSSS RAESPGPGSR LSSPKPKTLP ANRSSPSGAS
2810 2820 2830 2840 2850
SPRSSSPHDK NLPQKSTAPV KTKLDPPRER SKSDSYTLDP DTLRKKKMPL
2860 2870 2880 2890 2900
TEPLRGRSTS PKPKSVPKDS TDSPGSENRA PSPHVVQENL HSEVVEVCTS
2910 2920 2930 2940 2950
STLKTNSLTD STCDDSSEFK SVDEGSNKVH FSIGKAPLKD EQEMRASPKI
2960 2970 2980 2990 3000
SRKCANRHTR PKKEKSSFLF KGDGSKPLEP AKQAMSPSVA ECARAVFASF
3010 3020 3030 3040 3050
LWHEGIVHDA MACSSFLKFH PELSKEHAPI RSSLNSQQPT EEKETKLKNR
3060 3070 3080 3090 3100
HSLEISSALN MFNIAPHGPD ISKMGSINKN KVLSMLKEPP LHEKCEDGKT
3110 3120 3130 3140 3150
ETTFEMSMHN TMKSKSPLPL TLQHLVAFWE DISLATIKAA SQNMIFPSPG
3160 3170 3180 3190 3200
SCAVLKKKEC EKENKKSKKE KKKKEKAEVR PRGNLFGEMA QLAVGGPEKD
3210 3220 3230 3240 3250
TICELCGESH PYPVTYHMRQ AHPGCGRYAG GQGYNSIGHF CGGWAGNCGD
3260 3270 3280 3290 3300
GGIGGSTWYL VCDRCREKYL REKQAAAREK VKQSRRKPMQ VKTPRALPTM
3310 3320 3330 3340 3350
EAHQVIKANA LFLLSLSSAA EPSILCYHPA KPFQSQLPSV KEGISEDLPV
3360 3370 3380 3390 3400
KMPCLYLQTL ARHHHENFVG YQDDNLFQDE MRYLRSTSVP APYISVTPDA
3410 3420 3430 3440 3450
SPNVFEEPES NMKSMPPSLE TSPITDTDLA KRTVFQRSYS VVASEYDKQH
3460 3470 3480 3490 3500
SILPARVKAI PRRRVNSGDT EVGSSLLRHP SPELSRLISA HSSLSKGERN
3510 3520 3530 3540 3550
FQWPVLAFVI QHHDLEGLEI AMKQALRKSA CRVFAMEAFN WLLCNVIQTT
3560 3570 3580 3590 3600
SLHDILWHFV ASLTPAPVEP EEEEDEENKT SKENSEQEKD TRVCEHPLSD
3610 3620 3630 3640 3650
IVIAGEAAHP LPHTFHRLLQ TISDLMMSLP SGSSLQQMAL RCWSLKFKQS
3660 3670 3680 3690 3700
DHQFLHQSNV FHHINNILSK SDDGDSEESF SISIQSGFEA MSQELCIVMC
3710 3720 3730 3740 3750
LKDLTSIVDI KTSSRPAMIG SLTDGSTETF WESGDEDKNK TKNITINCVK
3760 3770 3780 3790 3800
GINARYVSVH VDNSRDLGNK VTSMTFLTGK AVEDLCRIKQ VDLDSRHIGW
3810 3820 3830 3840 3850
VTSELPGGDN HIIKIELKGP ENTLRVRQVK VLGWKDGEST KIAGQISASV
3860 3870 3880 3890 3900
AQQRNCEAET LRVFRLITSQ VFGKLISGDA EPTPEQEEKA LLSSPEGEEK
3910 3920 3930 3940 3950
VYNATSDADL KEHMVGIIFS RSKLTNLQKQ VCAHIVQAIR MEATRVREEW
3960 3970 3980 3990 4000
EHAISSKENA NSQPNDEDAS SDAYCFELLS MVLALSGSNV GRQYLAQQLT
4010 4020 4030 4040 4050
LLQDLFSLLH TASPRVQRQV TSLLRRVLPE VTPSRLASII GVKSLPPADI
4060 4070 4080 4090 4100
SDIIHSTEKG DWNKLGILDM FLGCIAKALT VQLKAKGTTI TGTAGTTVGK
4110 4120 4130 4140 4150
GVTTVTLPMI FNSSYLRRGE SHWWMKGSTP TQISEIIIKL IKDMAAGHLS
4160 4170 4180 4190 4200
EAWSRVTKNA IAETIIALTK MEEEFRSPVR CIATTRLWLA LASLCVLDQD
4210 4220 4230 4240 4250
HVDRLSSGRW MGKDGQQKQM PMCDNHDDGE TAAIILCNVC GNLCTDCDRF
4260 4270 4280 4290 4300
LHLHRRTKTH QRQVFKEEEE AIKVDLHEGC GRTKLFWLMA LADSKTMKAM
4310 4320 4330 4340 4350
VEFREHTGKP TTSSSEACRF CGSRSGTELS AVGSVCSDAD CQEYAKIACS
4360 4370 4380 4390 4400
KTHPCGHPCG GVKNEEHCLP CLHGCDKSAT SLKQDADDMC MICFTEALSA
4410 4420 4430 4440 4450
APAIQLDCSH IFHLQCCRRV LENRWLGPRI TFGFISCPIC KNKINHIVLK
4460 4470 4480 4490 4500
DLLDPIKELY EDVRRKALMR LEYEGLHKSE AITTPGVRFY NDPAGYAMNR
4510 4520 4530 4540 4550
YAYYVCYKCR KAYFGGEARC DAEAGRGDDY DPRELICGAC SDVSRAQMCP
4560 4570 4580 4590 4600
KHGTDFLEYK CRYCCSVAVF FCFGTTHFCN ACHDDFQRMT SIPKEELPHC
4610 4620 4630 4640
PAGPKGKQLE GTECPLHVVH PPTGEEFALG CGVCRNAHTF
Length:4,640
Mass (Da):510,084
Last modified:January 23, 2007 - v3
Checksum:i0557ADF6D26472D6
GO
Isoform 2Curated (identifier: O75592-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     3901-3903: Missing.

Note: Derived from EST data.Curated

Show »
Length:4,637
Mass (Da):509,708
Checksum:iA54457A00B327ADA
GO

Sequence cautioni

The sequence AAD39842.1 differs from that shown. Reason: Frameshift at position 4636.
The sequence AAH37971.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAI39758.1 differs from that shown. Reason: Erroneous gene model prediction.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti23 – 231R → P in AAC39928. (PubMed:9689053)Curated
Sequence conflicti202 – 2021G → V in AAC39928. (PubMed:9689053)Curated
Sequence conflicti472 – 4721G → R in AAC39928. (PubMed:9689053)Curated
Sequence conflicti580 – 5801T → I in AAC39928. (PubMed:9689053)Curated
Sequence conflicti865 – 8662QL → HV in AAC39928. (PubMed:9689053)Curated
Sequence conflicti1474 – 14752GV → PL in AAC39928. (PubMed:9689053)Curated
Sequence conflicti2101 – 21011K → M in AAC39928. (PubMed:9689053)Curated
Sequence conflicti3163 – 31631E → GR in AAC39928. (PubMed:9689053)Curated
Sequence conflicti3607 – 36071A → R in AAC39928. (PubMed:9689053)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1881 – 18811A → S.
Corresponds to variant rs35887505 [ dbSNP | Ensembl ].
VAR_052086
Natural varianti2588 – 25881V → M.
Corresponds to variant rs9574002 [ dbSNP | Ensembl ].
VAR_030070

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei3901 – 39033Missing in isoform 2. CuratedVSP_014183

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF075587 mRNA. Translation: AAC39928.1.
AL159154
, AL159158, AL359257, AC001226 Genomic DNA. Translation: CAH73736.1.
AL159158
, AL159154, AL359257, AC001226 Genomic DNA. Translation: CAI16842.1.
AL359257
, AL159158, AL159154, AC001226 Genomic DNA. Translation: CAI39759.1.
AL359257, AC001226 Genomic DNA. Translation: CAI39758.1. Sequence problems.
CH471093 Genomic DNA. Translation: EAW80565.1.
AB020723 mRNA. Translation: BAA74939.1.
BC037971 mRNA. Translation: AAH37971.1. Different initiation.
AF083244 mRNA. Translation: AAD39842.1. Sequence problems.
RefSeqiNP_055872.4. NM_015057.4.
UniGeneiHs.591221.

Genome annotation databases

EnsembliENST00000357337; ENSP00000349892; ENSG00000005810. [O75592-1]
ENST00000544440; ENSP00000444596; ENSG00000005810. [O75592-1]
ENST00000612956; ENSP00000483488; ENSG00000005810.
GeneIDi23077.
KEGGihsa:23077.
UCSCiuc010aev.3. human. [O75592-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF075587 mRNA. Translation: AAC39928.1 .
AL159154
, AL159158 , AL359257 , AC001226 Genomic DNA. Translation: CAH73736.1 .
AL159158
, AL159154 , AL359257 , AC001226 Genomic DNA. Translation: CAI16842.1 .
AL359257
, AL159158 , AL159154 , AC001226 Genomic DNA. Translation: CAI39759.1 .
AL359257 , AC001226 Genomic DNA. Translation: CAI39758.1 . Sequence problems.
CH471093 Genomic DNA. Translation: EAW80565.1 .
AB020723 mRNA. Translation: BAA74939.1 .
BC037971 mRNA. Translation: AAH37971.1 . Different initiation.
AF083244 mRNA. Translation: AAD39842.1 . Sequence problems.
RefSeqi NP_055872.4. NM_015057.4.
UniGenei Hs.591221.

3D structure databases

ProteinModelPortali O75592.
SMRi O75592. Positions 496-677, 880-986, 1189-1349, 1688-1847, 2330-2356.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116709. 34 interactions.
DIPi DIP-28142N.
IntActi O75592. 35 interactions.
MINTi MINT-1632199.
STRINGi 9606.ENSP00000349892.

PTM databases

PhosphoSitei O75592.

Proteomic databases

MaxQBi O75592.
PaxDbi O75592.
PRIDEi O75592.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000357337 ; ENSP00000349892 ; ENSG00000005810 . [O75592-1 ]
ENST00000544440 ; ENSP00000444596 ; ENSG00000005810 . [O75592-1 ]
ENST00000612956 ; ENSP00000483488 ; ENSG00000005810 .
GeneIDi 23077.
KEGGi hsa:23077.
UCSCi uc010aev.3. human. [O75592-1 ]

Organism-specific databases

CTDi 23077.
GeneCardsi GC13M077618.
HGNCi HGNC:23386. MYCBP2.
HPAi HPA039945.
MIMi 610392. gene.
neXtProti NX_O75592.
PharmGKBi PA134871126.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG240798.
GeneTreei ENSGT00390000011403.
HOVERGENi HBG053153.
InParanoidi O75592.
KOi K10693.
OrthoDBi EOG75B84C.
PhylomeDBi O75592.
TreeFami TF313151.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Miscellaneous databases

ChiTaRSi MYCBP2. human.
GeneWikii MYCBP2.
GenomeRNAii 23077.
NextBioi 44191.
PROi O75592.
SOURCEi Search...

Gene expression databases

Bgeei O75592.
CleanExi HS_MYCBP2.
HS_PAM.
ExpressionAtlasi O75592. baseline and differential.
Genevestigatori O75592.

Family and domain databases

Gene3Di 2.130.10.30. 2 hits.
2.60.120.260. 1 hit.
2.60.40.10. 2 hits.
3.30.40.10. 1 hit.
InterProi IPR004939. APC_su10/DOC_dom.
IPR017868. Filamin/ABP280_repeat-like.
IPR008979. Galactose-bd-like.
IPR027047. Highwire/Pam/Rpm-1.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR012983. PHR.
IPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
IPR003646. SH3-like_bac-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
PANTHERi PTHR12846:SF14. PTHR12846:SF14. 1 hit.
Pfami PF00630. Filamin. 1 hit.
PF08005. PHR. 2 hits.
PF00415. RCC1. 1 hit.
PF08239. SH3_3. 1 hit.
PF13639. zf-RING_2. 1 hit.
[Graphical view ]
PRINTSi PR00633. RCCNDNSATION.
SMARTi SM00184. RING. 1 hit.
[Graphical view ]
SUPFAMi SSF49785. SSF49785. 1 hit.
SSF50985. SSF50985. 2 hits.
SSF81296. SSF81296. 2 hits.
PROSITEi PS51284. DOC. 1 hit.
PS50194. FILAMIN_REPEAT. 1 hit.
PS00626. RCC1_2. 2 hits.
PS50012. RCC1_3. 3 hits.
PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a large Myc-binding protein that contains RCC1-like repeats."
    Guo Q., Xie J., Dang C.V., Liu E.T., Bishop J.M.
    Proc. Natl. Acad. Sci. U.S.A. 95:9172-9177(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH MYC, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORM 2).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3431-4640 (ISOFORM 1).
    Tissue: Brain1 Publication.
  5. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3789-4640 (ISOFORM 1).
    Tissue: BrainImported.
  7. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4367-4640.
    Tissue: Umbilical cord blood1 Publication.
  8. "Pam and its ortholog highwire interact with and may negatively regulate the TSC1.TSC2 complex."
    Murthy V., Han S., Beauchamp R.L., Smith N., Haddad L.A., Ito N., Ramesh V.
    J. Biol. Chem. 279:1351-1358(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TSC2.
  9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3052, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Pam (Protein associated with Myc) functions as an E3 ubiquitin ligase and regulates TSC/mTOR signaling."
    Han S., Witt R.M., Santos T.M., Polizzano C., Sabatini B.L., Ramesh V.
    Cell. Signal. 20:1084-1091(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, AUTOUBIQUITINATION.
  11. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3467, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-140; SER-143; SER-145; THR-2645; SER-2751; SER-3440 AND SER-3467, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "Fbxo45 forms a novel ubiquitin ligase complex and is required for neuronal development."
    Saiga T., Fukuda T., Matsumoto M., Tada H., Okano H.J., Okano H., Nakayama K.I.
    Mol. Cell. Biol. 29:3529-3543(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH FBXO45.
  15. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3467, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-2645; SER-2882 AND SER-3467, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-2645 AND SER-3467, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  18. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  19. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMYCB2_HUMAN
AccessioniPrimary (citable) accession number: O75592
Secondary accession number(s): A6NJC6
, Q5JSX8, Q5VZN6, Q6PIB6, Q9UQ11, Q9Y6E4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 136 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3