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O75592

- MYCB2_HUMAN

UniProt

O75592 - MYCB2_HUMAN

Protein

E3 ubiquitin-protein ligase MYCBP2

Gene

MYCBP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 135 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of TSC2/tuberin. Interacts with the E2 enzymes UBE2D1, UBE2D3 and UBE2L3 (in vitro). May function as a facilitator or regulator of transcriptional activation by MYC. May have a role during synaptogenesis.1 Publication

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri4390 – 444152RING-type; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri4544 – 459451B box-typeAdd
    BLAST

    GO - Molecular functioni

    1. ligase activity Source: UniProtKB-KW
    2. protein binding Source: IntAct
    3. ubiquitin-protein transferase activity Source: InterPro
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. branchiomotor neuron axon guidance Source: Ensembl
    2. central nervous system projection neuron axonogenesis Source: Ensembl
    3. regulation of cytoskeleton organization Source: Ensembl
    4. regulation of protein localization Source: Ensembl
    5. regulation of transcription, DNA-templated Source: UniProtKB-KW
    6. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Transcription, Transcription regulation, Ubl conjugation pathway

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    E3 ubiquitin-protein ligase MYCBP2 (EC:6.3.2.-)
    Alternative name(s):
    Myc-binding protein 2
    Pam/highwire/rpm-1 protein
    Protein associated with Myc
    Gene namesi
    Name:MYCBP2Imported
    Synonyms:KIAA0916Imported, PAM1 Publication
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 13

    Organism-specific databases

    HGNCiHGNC:23386. MYCBP2.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. axon Source: Ensembl
    2. membrane Source: UniProtKB
    3. microtubule cytoskeleton Source: Ensembl
    4. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134871126.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 46404640E3 ubiquitin-protein ligase MYCBP2PRO_0000055963Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei140 – 1401Phosphoserine1 Publication
    Modified residuei143 – 1431Phosphoserine1 Publication
    Modified residuei145 – 1451Phosphoserine1 Publication
    Disulfide bondi1710 ↔ 1825By similarity
    Modified residuei2645 – 26451Phosphothreonine3 Publications
    Modified residuei2751 – 27511Phosphoserine1 Publication
    Modified residuei2882 – 28821Phosphoserine1 Publication
    Modified residuei3052 – 30521Phosphoserine1 Publication
    Modified residuei3440 – 34401Phosphoserine1 Publication
    Modified residuei3467 – 34671Phosphoserine5 Publications

    Post-translational modificationi

    Autoubiquitinated.1 Publication

    Keywords - PTMi

    Disulfide bond, Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiO75592.
    PaxDbiO75592.
    PRIDEiO75592.

    PTM databases

    PhosphoSiteiO75592.

    Expressioni

    Tissue specificityi

    Expressed in all tissues examined, expression is exceptionally abundant in brain and thymus. Colocalizes with TSC1 and TSC2 along the neurites and in the growth cones. Colocalized with TSC1 in one of the filopodial extensions at the tip of a growth cone.1 Publication

    Gene expression databases

    ArrayExpressiO75592.
    BgeeiO75592.
    CleanExiHS_MYCBP2.
    HS_PAM.
    GenevestigatoriO75592.

    Organism-specific databases

    HPAiHPA039945.

    Interactioni

    Subunit structurei

    Interacts with MYC. Interacts with TSC2 (tuberin) when TSC2 is in complex with TSC1 (hamartin). Interacts with FBXO45.3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Q99IB83EBI-1043774,EBI-6927928From a different organism.
    Rae1Q3SWS82EBI-1043774,EBI-6920222From a different organism.

    Protein-protein interaction databases

    BioGridi116709. 25 interactions.
    DIPiDIP-28142N.
    IntActiO75592. 35 interactions.
    MINTiMINT-1632199.
    STRINGi9606.ENSP00000349892.

    Structurei

    3D structure databases

    ProteinModelPortaliO75592.
    SMRiO75592. Positions 496-677, 880-1022, 1189-1349, 1688-1847, 2366-2397, 4383-4447.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati562 – 61756RCC1 1Sequence AnalysisAdd
    BLAST
    Repeati661 – 71757RCC1 2Sequence AnalysisAdd
    BLAST
    Repeati869 – 91951RCC1 3Sequence AnalysisAdd
    BLAST
    Repeati920 – 97051RCC1 4Sequence AnalysisAdd
    BLAST
    Repeati972 – 102857RCC1 5Sequence AnalysisAdd
    BLAST
    Repeati2303 – 2405103FilaminSequence AnalysisAdd
    BLAST
    Domaini3681 – 3859179DOCPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1197 – 1348152PHR domain 1By similarityAdd
    BLAST
    Regioni1688 – 1846159PHR domain 2By similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi65 – 8824Lys-richSequence AnalysisAdd
    BLAST
    Compositional biasi728 – 77649Cys-richSequence AnalysisAdd
    BLAST
    Compositional biasi2682 – 2806125Ser-richSequence AnalysisAdd
    BLAST
    Compositional biasi3156 – 317722Lys-richSequence AnalysisAdd
    BLAST
    Compositional biasi3224 – 325532Gly-richAdd
    BLAST

    Domaini

    The PHR domains are compact beta-sandwich folds composed of 11 antiparallel strands and decorated with conserved apical loops. They are likely to play a structural role and mediate interactions with substrates or partners By similarity.By similarity

    Sequence similaritiesi

    Belongs to the highwire family.Curated
    Contains 1 B box-type zinc finger.Sequence Analysis
    Contains 1 DOC domain.PROSITE-ProRule annotation
    Contains 1 filamin repeat.PROSITE-ProRule annotation
    Contains 5 RCC1 repeats.PROSITE-ProRule annotation
    Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri4390 – 444152RING-type; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri4544 – 459451B box-typeAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG240798.
    HOVERGENiHBG053153.
    InParanoidiO75592.
    KOiK10693.
    OrthoDBiEOG75B84C.
    PhylomeDBiO75592.
    TreeFamiTF313151.

    Family and domain databases

    Gene3Di2.130.10.30. 2 hits.
    2.60.120.260. 1 hit.
    2.60.40.10. 2 hits.
    3.30.40.10. 1 hit.
    InterProiIPR004939. APC_su10/DOC_dom.
    IPR017868. Filamin/ABP280_repeat-like.
    IPR008979. Galactose-bd-like.
    IPR027047. Highwire/Pam/Rpm-1.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR012983. PHR.
    IPR009091. RCC1/BLIP-II.
    IPR000408. Reg_chr_condens.
    IPR003646. SH3-like_bac-type.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PANTHERiPTHR12846:SF14. PTHR12846:SF14. 1 hit.
    PfamiPF00630. Filamin. 1 hit.
    PF08005. PHR. 2 hits.
    PF00415. RCC1. 1 hit.
    PF08239. SH3_3. 1 hit.
    PF13639. zf-RING_2. 1 hit.
    [Graphical view]
    PRINTSiPR00633. RCCNDNSATION.
    SMARTiSM00184. RING. 1 hit.
    [Graphical view]
    SUPFAMiSSF49785. SSF49785. 1 hit.
    SSF50985. SSF50985. 2 hits.
    SSF81296. SSF81296. 2 hits.
    PROSITEiPS51284. DOC. 1 hit.
    PS50194. FILAMIN_REPEAT. 1 hit.
    PS00626. RCC1_2. 2 hits.
    PS50012. RCC1_3. 3 hits.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 11 Publication (identifier: O75592-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPVPDGSVAA AGLGLGLPAA DSRGHYQLLL SGRALADRYR RIYTAALNDR     50
    DQGGGSAGHP ASRNKKILNK KKLKRKQKSK SKVKTRSKSE NLENTVIIPD 100
    IKLHSNPSAF NIYCNVRHCV LEWQKKEISL AAASKNSVQS GESDSDEEEE 150
    SKEPPIKLPK IIEVGLCEVF ELIKETRFSH PSLCLRSLQA LLNVLQGQQP 200
    EGLQSEPPEV LESLFQLLLE ITVRSTGMND STGQSLTALS CACLFSLVAS 250
    WGETGRTLQA ISAILTNNGS HACQTIQVPT ILNSLQRSVQ AVLVGKIQIQ 300
    DWFSNGIKKA ALMHKWPLKE ISVDEDDQCL LQNDGFFLYL LCKDGLYKIG 350
    SGYSGTVRGH IYNSTSRIRN RKEKKSWLGY AQGYLLYRDV NNHSMTAIRI 400
    SPETLEQDGT VMLPDCHTEG QNILFTDGEY INQIAASRDD GFVVRIFATS 450
    TEPVLQQELQ LKLARKCLHA CGISLFDLEK DLHIISTGFD EESAILGAGR 500
    EFALMKTANG KIYYTGKYQS LGIKQGGPSA GKWVELPITK SPKIVHFSVG 550
    HDGSHALLVA EDGSIFFTGS ASKGEDGEST KSRRQSKPYK PKKIIKMEGK 600
    IVVYTACNNG SSSVISKDGE LYMFGKDAIY SDSSSLVTDL KGHFVTQVAM 650
    GKAHTCVLMK NGEVWTFGVN NKGQCGRDTG AMNQGGKGFG VENMATAMDE 700
    DLEEELDEKD EKSMMCPPGM HKWKLEQCMV CTVCGDCTGY GASCVSSGRP 750
    DRVPGGICGC GSGESGCAVC GCCKACAREL DGQEARQRGI LDAVKEMIPL 800
    DLLLAVPVPG VNIEEHLQLR QEEKRQRVIR RHRLEEGRGP LVFAGPIFMN 850
    HREQALARLR SHPAQLKHKR DKHKDGSGER GEKDASKITT YPPGSVRFDC 900
    ELRAVQVSCG FHHSVVLMEN GDVYTFGYGQ HGQLGHGDVN SRGCPTLVQA 950
    LPGPSTQVTA GSNHTAVLLM DGQVFTFGSF SKGQLGRPIL DVPYWNAKPA 1000
    PMPNIGSKYG RKATWIGASG DQTFLRIDEA LINSHVLATS EIFASKHIIG 1050
    LVPASISEPP PFKCLLINKV DGSCKTFNDS EQEDLQGFGV CLDPVYDVIW 1100
    RFRPNTRELW CYNAVVADAR LPSAADMQSR CSILSPELAL PTGSRALTTR 1150
    SHAALHILGC LDTLAAMQDL KMGVASTEEE TQAVMKVYSK EDYSVVNRFE 1200
    SHGGGWGYSA HSVEAIRFSA DTDILLGGLG LFGGRGEYTA KIKLFELGPD 1250
    GGDHETDGDL LAETDVLAYD CAAREKYAMM FDEPVLLQAG WWYVAWARVS 1300
    GPSSDCGSHG QASITTDDGV VFQFKSSKKS NNGTDVNAGQ IPQLLYRLPT 1350
    SDGSASKGKQ QTSEPVHILK RSFARTVSVE CFESLLSILH WSWTTLVLGV 1400
    EELRGLKGFQ FTATLLDLER LRFVGTCCLR LLRVYTCEIY PVSATGKAVV 1450
    EETSKLAECI GKTRTLLRKI LSEGVDHCMV KLDNDPQGYL SQPLSLLEAV 1500
    LQECHNTFTA CFHSFYPTPA LQWACLCDLL NCLDQDIQEA NFKTSSSRLL 1550
    AAVMSALCHT SVKLTSIFPI AYDGEVLLRS IVKQVSTEND STLVHRFPLL 1600
    VAHMEKLSQS EENISGMTSF REVLEKMLVI VVLPVRNSLR RENELFSSHL 1650
    VSNTCGLLAS IVSELTASAL GSEVDGLNSL HSVKASANRF TKTSQGRSWN 1700
    TGNGSPDAIC FSVDKPGIVV VGFSVYGGGG IHEYELEVLV DDSEHAGDST 1750
    HSHRWTSLEL VKGTYTTDDS PSDIAEIRLD KVVPLKENVK YAVRLRNYGS 1800
    RTANGDGGMT TVQCPDGVTF TFSTCSLSSN GTNQTRGQIP QILYYRSEFD 1850
    GDLQSQLLSK ANEEDKNCSR ALSVVSTVVR ASKDLLHRAL AVDADDIPEL 1900
    LSSSSLFSML LPLIIAYIGP VAAAIPKVAV EVFGLVQQLL PSVAILNQKY 1950
    APPAFNPNQS TDSTTGNQPE QGLSACTTSS HYAVIESEHP YKPACVMHYK 2000
    VTFPECVRWM TIEFDPQCGT AQSEDVLRLL IPVRTVQNSG YGPKLTSVHE 2050
    NLNSWIELKK FSGSSGWPTM VLVLPGNEAL FSLETASDYV KDDKASFYGF 2100
    KCFAIGYEFS PGPDEGVIQL EKELANLGGV CAAALMKKDL ALPIGNELEE 2150
    DLEILEEAAL QVCKTHSGIL GKGLALSHSP TILEALEGNL PLQIQSNEQS 2200
    FLDDFIACVP GSSGGRLARW LQPDSYADPQ KTSLILNKDD IRCGWPTTIT 2250
    VQTKDQYGDV VHVPNMKVEV KAVPVSQKKM SLQQDQAKKP QRIPGSPAVT 2300
    AASSNTDMTY GGLASPKLDV SYEPMIVKEA RYIAITMMKV YENYSFEELR 2350
    FASPTPKRPS ENMLIRVNND GTYCANWTPG AIGLYTLHVT IDGIEIDAGL 2400
    EVKVKDPPKG MIPPGTQLVK PKSEPQPNKV RKFVAKDSAG LRIRSHPSLQ 2450
    SEQIGIVKVN GTITFIDEIH NDDGVWLRLN DETIKKYVPN MNGYTEAWCL 2500
    SFNQHLGKSL LVPVDESKTN TDDFFKDINS CCPQEATMQE QDMPFLRGGP 2550
    GMYKVVKTGP SGHNIRSCPN LRGIPIGMLV LGNKVKAVGE VTNSEGTWVQ 2600
    LDQNSMVEFC ESDEGEAWSL ARDRGGNQYL RHEDEQALLD QNSQTPPPSP 2650
    FSVQAFNKGA SCSAQGFDYG LGNSKGDRGN ISTSSKPAST SGKSELSSKH 2700
    SRSLKPDGRM SRTTADQKKP RGTESLSASE SLILKSDAAK LRSDSHSRSL 2750
    SPNHNTLQTL KSDGRMPSSS RAESPGPGSR LSSPKPKTLP ANRSSPSGAS 2800
    SPRSSSPHDK NLPQKSTAPV KTKLDPPRER SKSDSYTLDP DTLRKKKMPL 2850
    TEPLRGRSTS PKPKSVPKDS TDSPGSENRA PSPHVVQENL HSEVVEVCTS 2900
    STLKTNSLTD STCDDSSEFK SVDEGSNKVH FSIGKAPLKD EQEMRASPKI 2950
    SRKCANRHTR PKKEKSSFLF KGDGSKPLEP AKQAMSPSVA ECARAVFASF 3000
    LWHEGIVHDA MACSSFLKFH PELSKEHAPI RSSLNSQQPT EEKETKLKNR 3050
    HSLEISSALN MFNIAPHGPD ISKMGSINKN KVLSMLKEPP LHEKCEDGKT 3100
    ETTFEMSMHN TMKSKSPLPL TLQHLVAFWE DISLATIKAA SQNMIFPSPG 3150
    SCAVLKKKEC EKENKKSKKE KKKKEKAEVR PRGNLFGEMA QLAVGGPEKD 3200
    TICELCGESH PYPVTYHMRQ AHPGCGRYAG GQGYNSIGHF CGGWAGNCGD 3250
    GGIGGSTWYL VCDRCREKYL REKQAAAREK VKQSRRKPMQ VKTPRALPTM 3300
    EAHQVIKANA LFLLSLSSAA EPSILCYHPA KPFQSQLPSV KEGISEDLPV 3350
    KMPCLYLQTL ARHHHENFVG YQDDNLFQDE MRYLRSTSVP APYISVTPDA 3400
    SPNVFEEPES NMKSMPPSLE TSPITDTDLA KRTVFQRSYS VVASEYDKQH 3450
    SILPARVKAI PRRRVNSGDT EVGSSLLRHP SPELSRLISA HSSLSKGERN 3500
    FQWPVLAFVI QHHDLEGLEI AMKQALRKSA CRVFAMEAFN WLLCNVIQTT 3550
    SLHDILWHFV ASLTPAPVEP EEEEDEENKT SKENSEQEKD TRVCEHPLSD 3600
    IVIAGEAAHP LPHTFHRLLQ TISDLMMSLP SGSSLQQMAL RCWSLKFKQS 3650
    DHQFLHQSNV FHHINNILSK SDDGDSEESF SISIQSGFEA MSQELCIVMC 3700
    LKDLTSIVDI KTSSRPAMIG SLTDGSTETF WESGDEDKNK TKNITINCVK 3750
    GINARYVSVH VDNSRDLGNK VTSMTFLTGK AVEDLCRIKQ VDLDSRHIGW 3800
    VTSELPGGDN HIIKIELKGP ENTLRVRQVK VLGWKDGEST KIAGQISASV 3850
    AQQRNCEAET LRVFRLITSQ VFGKLISGDA EPTPEQEEKA LLSSPEGEEK 3900
    VYNATSDADL KEHMVGIIFS RSKLTNLQKQ VCAHIVQAIR MEATRVREEW 3950
    EHAISSKENA NSQPNDEDAS SDAYCFELLS MVLALSGSNV GRQYLAQQLT 4000
    LLQDLFSLLH TASPRVQRQV TSLLRRVLPE VTPSRLASII GVKSLPPADI 4050
    SDIIHSTEKG DWNKLGILDM FLGCIAKALT VQLKAKGTTI TGTAGTTVGK 4100
    GVTTVTLPMI FNSSYLRRGE SHWWMKGSTP TQISEIIIKL IKDMAAGHLS 4150
    EAWSRVTKNA IAETIIALTK MEEEFRSPVR CIATTRLWLA LASLCVLDQD 4200
    HVDRLSSGRW MGKDGQQKQM PMCDNHDDGE TAAIILCNVC GNLCTDCDRF 4250
    LHLHRRTKTH QRQVFKEEEE AIKVDLHEGC GRTKLFWLMA LADSKTMKAM 4300
    VEFREHTGKP TTSSSEACRF CGSRSGTELS AVGSVCSDAD CQEYAKIACS 4350
    KTHPCGHPCG GVKNEEHCLP CLHGCDKSAT SLKQDADDMC MICFTEALSA 4400
    APAIQLDCSH IFHLQCCRRV LENRWLGPRI TFGFISCPIC KNKINHIVLK 4450
    DLLDPIKELY EDVRRKALMR LEYEGLHKSE AITTPGVRFY NDPAGYAMNR 4500
    YAYYVCYKCR KAYFGGEARC DAEAGRGDDY DPRELICGAC SDVSRAQMCP 4550
    KHGTDFLEYK CRYCCSVAVF FCFGTTHFCN ACHDDFQRMT SIPKEELPHC 4600
    PAGPKGKQLE GTECPLHVVH PPTGEEFALG CGVCRNAHTF 4640
    Length:4,640
    Mass (Da):510,084
    Last modified:January 23, 2007 - v3
    Checksum:i0557ADF6D26472D6
    GO
    Isoform 2Curated (identifier: O75592-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         3901-3903: Missing.

    Note: Derived from EST data.Curated

    Show »
    Length:4,637
    Mass (Da):509,708
    Checksum:iA54457A00B327ADA
    GO

    Sequence cautioni

    The sequence AAD39842.1 differs from that shown. Reason: Frameshift at position 4636.
    The sequence AAH37971.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAI39758.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti23 – 231R → P in AAC39928. (PubMed:9689053)Curated
    Sequence conflicti202 – 2021G → V in AAC39928. (PubMed:9689053)Curated
    Sequence conflicti472 – 4721G → R in AAC39928. (PubMed:9689053)Curated
    Sequence conflicti580 – 5801T → I in AAC39928. (PubMed:9689053)Curated
    Sequence conflicti865 – 8662QL → HV in AAC39928. (PubMed:9689053)Curated
    Sequence conflicti1474 – 14752GV → PL in AAC39928. (PubMed:9689053)Curated
    Sequence conflicti2101 – 21011K → M in AAC39928. (PubMed:9689053)Curated
    Sequence conflicti3163 – 31631E → GR in AAC39928. (PubMed:9689053)Curated
    Sequence conflicti3607 – 36071A → R in AAC39928. (PubMed:9689053)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti1881 – 18811A → S.
    Corresponds to variant rs35887505 [ dbSNP | Ensembl ].
    VAR_052086
    Natural varianti2588 – 25881V → M.
    Corresponds to variant rs9574002 [ dbSNP | Ensembl ].
    VAR_030070

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei3901 – 39033Missing in isoform 2. CuratedVSP_014183

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF075587 mRNA. Translation: AAC39928.1.
    AL159154
    , AL159158, AL359257, AC001226 Genomic DNA. Translation: CAH73736.1.
    AL159158
    , AL159154, AL359257, AC001226 Genomic DNA. Translation: CAI16842.1.
    AL359257
    , AL159158, AL159154, AC001226 Genomic DNA. Translation: CAI39759.1.
    AL359257, AC001226 Genomic DNA. Translation: CAI39758.1. Sequence problems.
    CH471093 Genomic DNA. Translation: EAW80565.1.
    AB020723 mRNA. Translation: BAA74939.1.
    BC037971 mRNA. Translation: AAH37971.1. Different initiation.
    AF083244 mRNA. Translation: AAD39842.1. Sequence problems.
    RefSeqiNP_055872.4. NM_015057.4.
    UniGeneiHs.591221.

    Genome annotation databases

    EnsembliENST00000357337; ENSP00000349892; ENSG00000005810. [O75592-1]
    ENST00000544440; ENSP00000444596; ENSG00000005810. [O75592-1]
    GeneIDi23077.
    KEGGihsa:23077.
    UCSCiuc010aev.3. human. [O75592-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF075587 mRNA. Translation: AAC39928.1 .
    AL159154
    , AL159158 , AL359257 , AC001226 Genomic DNA. Translation: CAH73736.1 .
    AL159158
    , AL159154 , AL359257 , AC001226 Genomic DNA. Translation: CAI16842.1 .
    AL359257
    , AL159158 , AL159154 , AC001226 Genomic DNA. Translation: CAI39759.1 .
    AL359257 , AC001226 Genomic DNA. Translation: CAI39758.1 . Sequence problems.
    CH471093 Genomic DNA. Translation: EAW80565.1 .
    AB020723 mRNA. Translation: BAA74939.1 .
    BC037971 mRNA. Translation: AAH37971.1 . Different initiation.
    AF083244 mRNA. Translation: AAD39842.1 . Sequence problems.
    RefSeqi NP_055872.4. NM_015057.4.
    UniGenei Hs.591221.

    3D structure databases

    ProteinModelPortali O75592.
    SMRi O75592. Positions 496-677, 880-1022, 1189-1349, 1688-1847, 2366-2397, 4383-4447.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116709. 25 interactions.
    DIPi DIP-28142N.
    IntActi O75592. 35 interactions.
    MINTi MINT-1632199.
    STRINGi 9606.ENSP00000349892.

    PTM databases

    PhosphoSitei O75592.

    Proteomic databases

    MaxQBi O75592.
    PaxDbi O75592.
    PRIDEi O75592.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000357337 ; ENSP00000349892 ; ENSG00000005810 . [O75592-1 ]
    ENST00000544440 ; ENSP00000444596 ; ENSG00000005810 . [O75592-1 ]
    GeneIDi 23077.
    KEGGi hsa:23077.
    UCSCi uc010aev.3. human. [O75592-1 ]

    Organism-specific databases

    CTDi 23077.
    GeneCardsi GC13M077618.
    HGNCi HGNC:23386. MYCBP2.
    HPAi HPA039945.
    MIMi 610392. gene.
    neXtProti NX_O75592.
    PharmGKBi PA134871126.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG240798.
    HOVERGENi HBG053153.
    InParanoidi O75592.
    KOi K10693.
    OrthoDBi EOG75B84C.
    PhylomeDBi O75592.
    TreeFami TF313151.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .

    Miscellaneous databases

    ChiTaRSi MYCBP2. human.
    GeneWikii MYCBP2.
    GenomeRNAii 23077.
    NextBioi 44191.
    PROi O75592.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O75592.
    Bgeei O75592.
    CleanExi HS_MYCBP2.
    HS_PAM.
    Genevestigatori O75592.

    Family and domain databases

    Gene3Di 2.130.10.30. 2 hits.
    2.60.120.260. 1 hit.
    2.60.40.10. 2 hits.
    3.30.40.10. 1 hit.
    InterProi IPR004939. APC_su10/DOC_dom.
    IPR017868. Filamin/ABP280_repeat-like.
    IPR008979. Galactose-bd-like.
    IPR027047. Highwire/Pam/Rpm-1.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR012983. PHR.
    IPR009091. RCC1/BLIP-II.
    IPR000408. Reg_chr_condens.
    IPR003646. SH3-like_bac-type.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    PANTHERi PTHR12846:SF14. PTHR12846:SF14. 1 hit.
    Pfami PF00630. Filamin. 1 hit.
    PF08005. PHR. 2 hits.
    PF00415. RCC1. 1 hit.
    PF08239. SH3_3. 1 hit.
    PF13639. zf-RING_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00633. RCCNDNSATION.
    SMARTi SM00184. RING. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49785. SSF49785. 1 hit.
    SSF50985. SSF50985. 2 hits.
    SSF81296. SSF81296. 2 hits.
    PROSITEi PS51284. DOC. 1 hit.
    PS50194. FILAMIN_REPEAT. 1 hit.
    PS00626. RCC1_2. 2 hits.
    PS50012. RCC1_3. 3 hits.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a large Myc-binding protein that contains RCC1-like repeats."
      Guo Q., Xie J., Dang C.V., Liu E.T., Bishop J.M.
      Proc. Natl. Acad. Sci. U.S.A. 95:9172-9177(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH MYC, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    2. "The DNA sequence and analysis of human chromosome 13."
      Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
      Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORM 2).
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3431-4640 (ISOFORM 1).
      Tissue: Brain1 Publication.
    5. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
      DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3789-4640 (ISOFORM 1).
      Tissue: BrainImported.
    7. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
      Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
      , Gu J., Chen S.-J., Chen Z.
      Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4367-4640.
      Tissue: Umbilical cord blood1 Publication.
    8. "Pam and its ortholog highwire interact with and may negatively regulate the TSC1.TSC2 complex."
      Murthy V., Han S., Beauchamp R.L., Smith N., Haddad L.A., Ito N., Ramesh V.
      J. Biol. Chem. 279:1351-1358(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TSC2.
    9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3052, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Pam (Protein associated with Myc) functions as an E3 ubiquitin ligase and regulates TSC/mTOR signaling."
      Han S., Witt R.M., Santos T.M., Polizzano C., Sabatini B.L., Ramesh V.
      Cell. Signal. 20:1084-1091(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, AUTOUBIQUITINATION.
    11. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3467, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-140; SER-143; SER-145; THR-2645; SER-2751; SER-3440 AND SER-3467, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. "Fbxo45 forms a novel ubiquitin ligase complex and is required for neuronal development."
      Saiga T., Fukuda T., Matsumoto M., Tada H., Okano H.J., Okano H., Nakayama K.I.
      Mol. Cell. Biol. 29:3529-3543(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH FBXO45.
    15. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3467, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    16. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-2645; SER-2882 AND SER-3467, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-2645 AND SER-3467, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    18. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    19. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiMYCB2_HUMAN
    AccessioniPrimary (citable) accession number: O75592
    Secondary accession number(s): A6NJC6
    , Q5JSX8, Q5VZN6, Q6PIB6, Q9UQ11, Q9Y6E4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 21, 2005
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 135 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 13
      Human chromosome 13: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3