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O75592

- MYCB2_HUMAN

UniProt

O75592 - MYCB2_HUMAN

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Protein

E3 ubiquitin-protein ligase MYCBP2

Gene
MYCBP2, KIAA0916, PAM
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of TSC2/tuberin. Interacts with the E2 enzymes UBE2D1, UBE2D3 and UBE2L3 (in vitro). May function as a facilitator or regulator of transcriptional activation by MYC. May have a role during synaptogenesis.1 Publication

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri4390 – 444152RING-type; atypicalAdd
BLAST
Zinc fingeri4544 – 459451B box-typeAdd
BLAST

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. protein binding Source: IntAct
  3. ubiquitin-protein transferase activity Source: InterPro
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. branchiomotor neuron axon guidance Source: Ensembl
  2. central nervous system projection neuron axonogenesis Source: Ensembl
  3. regulation of cytoskeleton organization Source: Ensembl
  4. regulation of protein localization Source: Ensembl
  5. regulation of transcription, DNA-templated Source: UniProtKB-KW
  6. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Transcription, Transcription regulation, Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase MYCBP2 (EC:6.3.2.-)
Alternative name(s):
Myc-binding protein 2
Pam/highwire/rpm-1 protein
Protein associated with Myc
Gene namesi
Name:MYCBP2
Synonyms:KIAA0916, PAM
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:23386. MYCBP2.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. axon Source: Ensembl
  2. microtubule cytoskeleton Source: Ensembl
  3. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134871126.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 46404640E3 ubiquitin-protein ligase MYCBP2PRO_0000055963Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei140 – 1401Phosphoserine1 Publication
Modified residuei143 – 1431Phosphoserine1 Publication
Modified residuei145 – 1451Phosphoserine1 Publication
Disulfide bondi1710 ↔ 1825 By similarity
Modified residuei2645 – 26451Phosphothreonine3 Publications
Modified residuei2751 – 27511Phosphoserine1 Publication
Modified residuei2882 – 28821Phosphoserine1 Publication
Modified residuei3052 – 30521Phosphoserine1 Publication
Modified residuei3440 – 34401Phosphoserine1 Publication
Modified residuei3467 – 34671Phosphoserine5 Publications

Post-translational modificationi

Autoubiquitinated.

Keywords - PTMi

Disulfide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiO75592.
PaxDbiO75592.
PRIDEiO75592.

PTM databases

PhosphoSiteiO75592.

Expressioni

Tissue specificityi

Expressed in all tissues examined, expression is exceptionally abundant in brain and thymus. Colocalizes with TSC1 and TSC2 along the neurites and in the growth cones. Colocalized with TSC1 in one of the filopodial extensions at the tip of a growth cone.1 Publication

Gene expression databases

ArrayExpressiO75592.
BgeeiO75592.
CleanExiHS_MYCBP2.
HS_PAM.
GenevestigatoriO75592.

Organism-specific databases

HPAiHPA039945.

Interactioni

Subunit structurei

Interacts with MYC. Interacts with TSC2 (tuberin) when TSC2 is in complex with TSC1 (hamartin). Interacts with FBXO45.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Q99IB83EBI-1043774,EBI-6927928From a different organism.
Rae1Q3SWS82EBI-1043774,EBI-6920222From a different organism.

Protein-protein interaction databases

BioGridi116709. 25 interactions.
DIPiDIP-28142N.
IntActiO75592. 35 interactions.
MINTiMINT-1632199.
STRINGi9606.ENSP00000349892.

Structurei

3D structure databases

ProteinModelPortaliO75592.
SMRiO75592. Positions 496-677, 880-1022, 1189-1349, 1688-1847, 2366-2397, 4383-4447.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati562 – 61756RCC1 1Add
BLAST
Repeati661 – 71757RCC1 2Add
BLAST
Repeati869 – 91951RCC1 3Add
BLAST
Repeati920 – 97051RCC1 4Add
BLAST
Repeati972 – 102857RCC1 5Add
BLAST
Repeati2303 – 2405103FilaminAdd
BLAST
Domaini3681 – 3859179DOCAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1197 – 1348152PHR domain 1 By similarityAdd
BLAST
Regioni1688 – 1846159PHR domain 2 By similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi65 – 8824Lys-richAdd
BLAST
Compositional biasi728 – 77649Cys-richAdd
BLAST
Compositional biasi2682 – 2806125Ser-richAdd
BLAST
Compositional biasi3156 – 317722Lys-richAdd
BLAST
Compositional biasi3224 – 325532Gly-richAdd
BLAST

Domaini

The PHR domains are compact beta-sandwich folds composed of 11 antiparallel strands and decorated with conserved apical loops. They are likely to play a structural role and mediate interactions with substrates or partners By similarity.

Sequence similaritiesi

Belongs to the highwire family.
Contains 1 DOC domain.
Contains 1 filamin repeat.
Contains 5 RCC1 repeats.

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri4390 – 444152RING-type; atypicalAdd
BLAST
Zinc fingeri4544 – 459451B box-typeAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG240798.
HOVERGENiHBG053153.
InParanoidiO75592.
KOiK10693.
OrthoDBiEOG75B84C.
PhylomeDBiO75592.
TreeFamiTF313151.

Family and domain databases

Gene3Di2.130.10.30. 2 hits.
2.60.120.260. 1 hit.
2.60.40.10. 2 hits.
3.30.40.10. 1 hit.
InterProiIPR004939. APC_su10/DOC_dom.
IPR017868. Filamin/ABP280_repeat-like.
IPR008979. Galactose-bd-like.
IPR027047. Highwire/Pam/Rpm-1.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR012983. PHR.
IPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
IPR003646. SH3-like_bac-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR12846:SF14. PTHR12846:SF14. 1 hit.
PfamiPF00630. Filamin. 1 hit.
PF08005. PHR. 2 hits.
PF00415. RCC1. 1 hit.
PF08239. SH3_3. 1 hit.
PF13639. zf-RING_2. 1 hit.
[Graphical view]
PRINTSiPR00633. RCCNDNSATION.
SMARTiSM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF50985. SSF50985. 2 hits.
SSF81296. SSF81296. 2 hits.
PROSITEiPS51284. DOC. 1 hit.
PS50194. FILAMIN_REPEAT. 1 hit.
PS00626. RCC1_2. 2 hits.
PS50012. RCC1_3. 3 hits.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 11 Publication (identifier: O75592-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MPVPDGSVAA AGLGLGLPAA DSRGHYQLLL SGRALADRYR RIYTAALNDR     50
DQGGGSAGHP ASRNKKILNK KKLKRKQKSK SKVKTRSKSE NLENTVIIPD 100
IKLHSNPSAF NIYCNVRHCV LEWQKKEISL AAASKNSVQS GESDSDEEEE 150
SKEPPIKLPK IIEVGLCEVF ELIKETRFSH PSLCLRSLQA LLNVLQGQQP 200
EGLQSEPPEV LESLFQLLLE ITVRSTGMND STGQSLTALS CACLFSLVAS 250
WGETGRTLQA ISAILTNNGS HACQTIQVPT ILNSLQRSVQ AVLVGKIQIQ 300
DWFSNGIKKA ALMHKWPLKE ISVDEDDQCL LQNDGFFLYL LCKDGLYKIG 350
SGYSGTVRGH IYNSTSRIRN RKEKKSWLGY AQGYLLYRDV NNHSMTAIRI 400
SPETLEQDGT VMLPDCHTEG QNILFTDGEY INQIAASRDD GFVVRIFATS 450
TEPVLQQELQ LKLARKCLHA CGISLFDLEK DLHIISTGFD EESAILGAGR 500
EFALMKTANG KIYYTGKYQS LGIKQGGPSA GKWVELPITK SPKIVHFSVG 550
HDGSHALLVA EDGSIFFTGS ASKGEDGEST KSRRQSKPYK PKKIIKMEGK 600
IVVYTACNNG SSSVISKDGE LYMFGKDAIY SDSSSLVTDL KGHFVTQVAM 650
GKAHTCVLMK NGEVWTFGVN NKGQCGRDTG AMNQGGKGFG VENMATAMDE 700
DLEEELDEKD EKSMMCPPGM HKWKLEQCMV CTVCGDCTGY GASCVSSGRP 750
DRVPGGICGC GSGESGCAVC GCCKACAREL DGQEARQRGI LDAVKEMIPL 800
DLLLAVPVPG VNIEEHLQLR QEEKRQRVIR RHRLEEGRGP LVFAGPIFMN 850
HREQALARLR SHPAQLKHKR DKHKDGSGER GEKDASKITT YPPGSVRFDC 900
ELRAVQVSCG FHHSVVLMEN GDVYTFGYGQ HGQLGHGDVN SRGCPTLVQA 950
LPGPSTQVTA GSNHTAVLLM DGQVFTFGSF SKGQLGRPIL DVPYWNAKPA 1000
PMPNIGSKYG RKATWIGASG DQTFLRIDEA LINSHVLATS EIFASKHIIG 1050
LVPASISEPP PFKCLLINKV DGSCKTFNDS EQEDLQGFGV CLDPVYDVIW 1100
RFRPNTRELW CYNAVVADAR LPSAADMQSR CSILSPELAL PTGSRALTTR 1150
SHAALHILGC LDTLAAMQDL KMGVASTEEE TQAVMKVYSK EDYSVVNRFE 1200
SHGGGWGYSA HSVEAIRFSA DTDILLGGLG LFGGRGEYTA KIKLFELGPD 1250
GGDHETDGDL LAETDVLAYD CAAREKYAMM FDEPVLLQAG WWYVAWARVS 1300
GPSSDCGSHG QASITTDDGV VFQFKSSKKS NNGTDVNAGQ IPQLLYRLPT 1350
SDGSASKGKQ QTSEPVHILK RSFARTVSVE CFESLLSILH WSWTTLVLGV 1400
EELRGLKGFQ FTATLLDLER LRFVGTCCLR LLRVYTCEIY PVSATGKAVV 1450
EETSKLAECI GKTRTLLRKI LSEGVDHCMV KLDNDPQGYL SQPLSLLEAV 1500
LQECHNTFTA CFHSFYPTPA LQWACLCDLL NCLDQDIQEA NFKTSSSRLL 1550
AAVMSALCHT SVKLTSIFPI AYDGEVLLRS IVKQVSTEND STLVHRFPLL 1600
VAHMEKLSQS EENISGMTSF REVLEKMLVI VVLPVRNSLR RENELFSSHL 1650
VSNTCGLLAS IVSELTASAL GSEVDGLNSL HSVKASANRF TKTSQGRSWN 1700
TGNGSPDAIC FSVDKPGIVV VGFSVYGGGG IHEYELEVLV DDSEHAGDST 1750
HSHRWTSLEL VKGTYTTDDS PSDIAEIRLD KVVPLKENVK YAVRLRNYGS 1800
RTANGDGGMT TVQCPDGVTF TFSTCSLSSN GTNQTRGQIP QILYYRSEFD 1850
GDLQSQLLSK ANEEDKNCSR ALSVVSTVVR ASKDLLHRAL AVDADDIPEL 1900
LSSSSLFSML LPLIIAYIGP VAAAIPKVAV EVFGLVQQLL PSVAILNQKY 1950
APPAFNPNQS TDSTTGNQPE QGLSACTTSS HYAVIESEHP YKPACVMHYK 2000
VTFPECVRWM TIEFDPQCGT AQSEDVLRLL IPVRTVQNSG YGPKLTSVHE 2050
NLNSWIELKK FSGSSGWPTM VLVLPGNEAL FSLETASDYV KDDKASFYGF 2100
KCFAIGYEFS PGPDEGVIQL EKELANLGGV CAAALMKKDL ALPIGNELEE 2150
DLEILEEAAL QVCKTHSGIL GKGLALSHSP TILEALEGNL PLQIQSNEQS 2200
FLDDFIACVP GSSGGRLARW LQPDSYADPQ KTSLILNKDD IRCGWPTTIT 2250
VQTKDQYGDV VHVPNMKVEV KAVPVSQKKM SLQQDQAKKP QRIPGSPAVT 2300
AASSNTDMTY GGLASPKLDV SYEPMIVKEA RYIAITMMKV YENYSFEELR 2350
FASPTPKRPS ENMLIRVNND GTYCANWTPG AIGLYTLHVT IDGIEIDAGL 2400
EVKVKDPPKG MIPPGTQLVK PKSEPQPNKV RKFVAKDSAG LRIRSHPSLQ 2450
SEQIGIVKVN GTITFIDEIH NDDGVWLRLN DETIKKYVPN MNGYTEAWCL 2500
SFNQHLGKSL LVPVDESKTN TDDFFKDINS CCPQEATMQE QDMPFLRGGP 2550
GMYKVVKTGP SGHNIRSCPN LRGIPIGMLV LGNKVKAVGE VTNSEGTWVQ 2600
LDQNSMVEFC ESDEGEAWSL ARDRGGNQYL RHEDEQALLD QNSQTPPPSP 2650
FSVQAFNKGA SCSAQGFDYG LGNSKGDRGN ISTSSKPAST SGKSELSSKH 2700
SRSLKPDGRM SRTTADQKKP RGTESLSASE SLILKSDAAK LRSDSHSRSL 2750
SPNHNTLQTL KSDGRMPSSS RAESPGPGSR LSSPKPKTLP ANRSSPSGAS 2800
SPRSSSPHDK NLPQKSTAPV KTKLDPPRER SKSDSYTLDP DTLRKKKMPL 2850
TEPLRGRSTS PKPKSVPKDS TDSPGSENRA PSPHVVQENL HSEVVEVCTS 2900
STLKTNSLTD STCDDSSEFK SVDEGSNKVH FSIGKAPLKD EQEMRASPKI 2950
SRKCANRHTR PKKEKSSFLF KGDGSKPLEP AKQAMSPSVA ECARAVFASF 3000
LWHEGIVHDA MACSSFLKFH PELSKEHAPI RSSLNSQQPT EEKETKLKNR 3050
HSLEISSALN MFNIAPHGPD ISKMGSINKN KVLSMLKEPP LHEKCEDGKT 3100
ETTFEMSMHN TMKSKSPLPL TLQHLVAFWE DISLATIKAA SQNMIFPSPG 3150
SCAVLKKKEC EKENKKSKKE KKKKEKAEVR PRGNLFGEMA QLAVGGPEKD 3200
TICELCGESH PYPVTYHMRQ AHPGCGRYAG GQGYNSIGHF CGGWAGNCGD 3250
GGIGGSTWYL VCDRCREKYL REKQAAAREK VKQSRRKPMQ VKTPRALPTM 3300
EAHQVIKANA LFLLSLSSAA EPSILCYHPA KPFQSQLPSV KEGISEDLPV 3350
KMPCLYLQTL ARHHHENFVG YQDDNLFQDE MRYLRSTSVP APYISVTPDA 3400
SPNVFEEPES NMKSMPPSLE TSPITDTDLA KRTVFQRSYS VVASEYDKQH 3450
SILPARVKAI PRRRVNSGDT EVGSSLLRHP SPELSRLISA HSSLSKGERN 3500
FQWPVLAFVI QHHDLEGLEI AMKQALRKSA CRVFAMEAFN WLLCNVIQTT 3550
SLHDILWHFV ASLTPAPVEP EEEEDEENKT SKENSEQEKD TRVCEHPLSD 3600
IVIAGEAAHP LPHTFHRLLQ TISDLMMSLP SGSSLQQMAL RCWSLKFKQS 3650
DHQFLHQSNV FHHINNILSK SDDGDSEESF SISIQSGFEA MSQELCIVMC 3700
LKDLTSIVDI KTSSRPAMIG SLTDGSTETF WESGDEDKNK TKNITINCVK 3750
GINARYVSVH VDNSRDLGNK VTSMTFLTGK AVEDLCRIKQ VDLDSRHIGW 3800
VTSELPGGDN HIIKIELKGP ENTLRVRQVK VLGWKDGEST KIAGQISASV 3850
AQQRNCEAET LRVFRLITSQ VFGKLISGDA EPTPEQEEKA LLSSPEGEEK 3900
VYNATSDADL KEHMVGIIFS RSKLTNLQKQ VCAHIVQAIR MEATRVREEW 3950
EHAISSKENA NSQPNDEDAS SDAYCFELLS MVLALSGSNV GRQYLAQQLT 4000
LLQDLFSLLH TASPRVQRQV TSLLRRVLPE VTPSRLASII GVKSLPPADI 4050
SDIIHSTEKG DWNKLGILDM FLGCIAKALT VQLKAKGTTI TGTAGTTVGK 4100
GVTTVTLPMI FNSSYLRRGE SHWWMKGSTP TQISEIIIKL IKDMAAGHLS 4150
EAWSRVTKNA IAETIIALTK MEEEFRSPVR CIATTRLWLA LASLCVLDQD 4200
HVDRLSSGRW MGKDGQQKQM PMCDNHDDGE TAAIILCNVC GNLCTDCDRF 4250
LHLHRRTKTH QRQVFKEEEE AIKVDLHEGC GRTKLFWLMA LADSKTMKAM 4300
VEFREHTGKP TTSSSEACRF CGSRSGTELS AVGSVCSDAD CQEYAKIACS 4350
KTHPCGHPCG GVKNEEHCLP CLHGCDKSAT SLKQDADDMC MICFTEALSA 4400
APAIQLDCSH IFHLQCCRRV LENRWLGPRI TFGFISCPIC KNKINHIVLK 4450
DLLDPIKELY EDVRRKALMR LEYEGLHKSE AITTPGVRFY NDPAGYAMNR 4500
YAYYVCYKCR KAYFGGEARC DAEAGRGDDY DPRELICGAC SDVSRAQMCP 4550
KHGTDFLEYK CRYCCSVAVF FCFGTTHFCN ACHDDFQRMT SIPKEELPHC 4600
PAGPKGKQLE GTECPLHVVH PPTGEEFALG CGVCRNAHTF 4640
Length:4,640
Mass (Da):510,084
Last modified:January 23, 2007 - v3
Checksum:i0557ADF6D26472D6
GO
Isoform 2 (identifier: O75592-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     3901-3903: Missing.

Note: Derived from EST data.

Show »
Length:4,637
Mass (Da):509,708
Checksum:iA54457A00B327ADA
GO

Sequence cautioni

The sequence AAD39842.1 differs from that shown. Reason: Frameshift at position 4636.
The sequence AAH37971.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAI39758.1 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1881 – 18811A → S.
Corresponds to variant rs35887505 [ dbSNP | Ensembl ].
VAR_052086
Natural varianti2588 – 25881V → M.
Corresponds to variant rs9574002 [ dbSNP | Ensembl ].
VAR_030070

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei3901 – 39033Missing in isoform 2. VSP_014183

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti23 – 231R → P in AAC39928. 1 Publication
Sequence conflicti202 – 2021G → V in AAC39928. 1 Publication
Sequence conflicti472 – 4721G → R in AAC39928. 1 Publication
Sequence conflicti580 – 5801T → I in AAC39928. 1 Publication
Sequence conflicti865 – 8662QL → HV in AAC39928. 1 Publication
Sequence conflicti1474 – 14752GV → PL in AAC39928. 1 Publication
Sequence conflicti2101 – 21011K → M in AAC39928. 1 Publication
Sequence conflicti3163 – 31631E → GR in AAC39928. 1 Publication
Sequence conflicti3607 – 36071A → R in AAC39928. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF075587 mRNA. Translation: AAC39928.1.
AL159154
, AL159158, AL359257, AC001226 Genomic DNA. Translation: CAH73736.1.
AL159158
, AL159154, AL359257, AC001226 Genomic DNA. Translation: CAI16842.1.
AL359257
, AL159158, AL159154, AC001226 Genomic DNA. Translation: CAI39759.1.
AL359257, AC001226 Genomic DNA. Translation: CAI39758.1. Sequence problems.
CH471093 Genomic DNA. Translation: EAW80565.1.
AB020723 mRNA. Translation: BAA74939.1.
BC037971 mRNA. Translation: AAH37971.1. Different initiation.
AF083244 mRNA. Translation: AAD39842.1. Sequence problems.
RefSeqiNP_055872.4. NM_015057.4.
UniGeneiHs.591221.

Genome annotation databases

EnsembliENST00000357337; ENSP00000349892; ENSG00000005810. [O75592-1]
ENST00000544440; ENSP00000444596; ENSG00000005810. [O75592-1]
GeneIDi23077.
KEGGihsa:23077.
UCSCiuc010aev.3. human. [O75592-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF075587 mRNA. Translation: AAC39928.1 .
AL159154
, AL159158 , AL359257 , AC001226 Genomic DNA. Translation: CAH73736.1 .
AL159158
, AL159154 , AL359257 , AC001226 Genomic DNA. Translation: CAI16842.1 .
AL359257
, AL159158 , AL159154 , AC001226 Genomic DNA. Translation: CAI39759.1 .
AL359257 , AC001226 Genomic DNA. Translation: CAI39758.1 . Sequence problems.
CH471093 Genomic DNA. Translation: EAW80565.1 .
AB020723 mRNA. Translation: BAA74939.1 .
BC037971 mRNA. Translation: AAH37971.1 . Different initiation.
AF083244 mRNA. Translation: AAD39842.1 . Sequence problems.
RefSeqi NP_055872.4. NM_015057.4.
UniGenei Hs.591221.

3D structure databases

ProteinModelPortali O75592.
SMRi O75592. Positions 496-677, 880-1022, 1189-1349, 1688-1847, 2366-2397, 4383-4447.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116709. 25 interactions.
DIPi DIP-28142N.
IntActi O75592. 35 interactions.
MINTi MINT-1632199.
STRINGi 9606.ENSP00000349892.

PTM databases

PhosphoSitei O75592.

Proteomic databases

MaxQBi O75592.
PaxDbi O75592.
PRIDEi O75592.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000357337 ; ENSP00000349892 ; ENSG00000005810 . [O75592-1 ]
ENST00000544440 ; ENSP00000444596 ; ENSG00000005810 . [O75592-1 ]
GeneIDi 23077.
KEGGi hsa:23077.
UCSCi uc010aev.3. human. [O75592-1 ]

Organism-specific databases

CTDi 23077.
GeneCardsi GC13M077618.
HGNCi HGNC:23386. MYCBP2.
HPAi HPA039945.
MIMi 610392. gene.
neXtProti NX_O75592.
PharmGKBi PA134871126.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG240798.
HOVERGENi HBG053153.
InParanoidi O75592.
KOi K10693.
OrthoDBi EOG75B84C.
PhylomeDBi O75592.
TreeFami TF313151.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Miscellaneous databases

ChiTaRSi MYCBP2. human.
GeneWikii MYCBP2.
GenomeRNAii 23077.
NextBioi 44191.
PROi O75592.
SOURCEi Search...

Gene expression databases

ArrayExpressi O75592.
Bgeei O75592.
CleanExi HS_MYCBP2.
HS_PAM.
Genevestigatori O75592.

Family and domain databases

Gene3Di 2.130.10.30. 2 hits.
2.60.120.260. 1 hit.
2.60.40.10. 2 hits.
3.30.40.10. 1 hit.
InterProi IPR004939. APC_su10/DOC_dom.
IPR017868. Filamin/ABP280_repeat-like.
IPR008979. Galactose-bd-like.
IPR027047. Highwire/Pam/Rpm-1.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR012983. PHR.
IPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
IPR003646. SH3-like_bac-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
PANTHERi PTHR12846:SF14. PTHR12846:SF14. 1 hit.
Pfami PF00630. Filamin. 1 hit.
PF08005. PHR. 2 hits.
PF00415. RCC1. 1 hit.
PF08239. SH3_3. 1 hit.
PF13639. zf-RING_2. 1 hit.
[Graphical view ]
PRINTSi PR00633. RCCNDNSATION.
SMARTi SM00184. RING. 1 hit.
[Graphical view ]
SUPFAMi SSF49785. SSF49785. 1 hit.
SSF50985. SSF50985. 2 hits.
SSF81296. SSF81296. 2 hits.
PROSITEi PS51284. DOC. 1 hit.
PS50194. FILAMIN_REPEAT. 1 hit.
PS00626. RCC1_2. 2 hits.
PS50012. RCC1_3. 3 hits.
PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a large Myc-binding protein that contains RCC1-like repeats."
    Guo Q., Xie J., Dang C.V., Liu E.T., Bishop J.M.
    Proc. Natl. Acad. Sci. U.S.A. 95:9172-9177(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH MYC, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORM 2).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3431-4640 (ISOFORM 1).
    Tissue: Brain.
  5. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3789-4640 (ISOFORM 1).
    Tissue: Brain.
  7. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4367-4640.
    Tissue: Umbilical cord blood.
  8. "Pam and its ortholog highwire interact with and may negatively regulate the TSC1.TSC2 complex."
    Murthy V., Han S., Beauchamp R.L., Smith N., Haddad L.A., Ito N., Ramesh V.
    J. Biol. Chem. 279:1351-1358(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TSC2.
  9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3052, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Pam (Protein associated with Myc) functions as an E3 ubiquitin ligase and regulates TSC/mTOR signaling."
    Han S., Witt R.M., Santos T.M., Polizzano C., Sabatini B.L., Ramesh V.
    Cell. Signal. 20:1084-1091(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, AUTOUBIQUITINATION.
  11. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3467, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-140; SER-143; SER-145; THR-2645; SER-2751; SER-3440 AND SER-3467, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "Fbxo45 forms a novel ubiquitin ligase complex and is required for neuronal development."
    Saiga T., Fukuda T., Matsumoto M., Tada H., Okano H.J., Okano H., Nakayama K.I.
    Mol. Cell. Biol. 29:3529-3543(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH FBXO45.
  15. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3467, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-2645; SER-2882 AND SER-3467, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-2645 AND SER-3467, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  18. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  19. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMYCB2_HUMAN
AccessioniPrimary (citable) accession number: O75592
Secondary accession number(s): A6NJC6
, Q5JSX8, Q5VZN6, Q6PIB6, Q9UQ11, Q9Y6E4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 134 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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