UniProtKB - O75582 (KS6A5_HUMAN)
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Protein
Ribosomal protein S6 kinase alpha-5
Gene
RPS6KA5
Organism
Homo sapiens (Human)
Status
Functioni
Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes (PubMed:11909979, PubMed:12569367, PubMed:12763138, PubMed:9687510, PubMed:18511904, PubMed:9873047). Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin (PubMed:11909979, PubMed:9873047). Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression (PubMed:12628924, PubMed:18511904). In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress (PubMed:12628924). In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential (PubMed:12763138). Phosphorylates ETV1/ER81 at 'Ser-191' and 'Ser-216', and thereby regulates its ability to stimulate transcription, which may be important during development and breast tumor formation (PubMed:12569367). Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A (PubMed:15010469). Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN (PubMed:12773393). May also phosphorylate 'Ser-28' of histone H3 (PubMed:12773393). Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14) (PubMed:12773393). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines (By similarity). Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors (By similarity). Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury (By similarity). Phosphorylates TRIM7 at 'Ser-107' in response to growth factor signaling via the MEK/ERK pathway, thereby stimulating its ubiquitin ligase activity (PubMed:25851810).By similarity10 Publications
Miscellaneous
Enzyme activity requires the presence of both kinase domains.1 Publication
Catalytic activityi
ATP + a protein = ADP + a phosphoprotein.3 Publications
Cofactori
Mg2+3 Publications
Enzyme regulationi
Activated by phosphorylation at Ser-360, Thr-581 and Thr-700 by MAPK1/ERK2, MAPK3/ERK1 and MAPK14/p38-alpha, and by further autophosphorylation of Ser-212, Ser-376 and Ser-381 by the activated C-terminal kinase domain. The active N-terminal kinase domain finally phosphorylates downstream substrates, as well as Ser-750, Ser-752 and Ser-758 in its own C-terminal region.2 Publications
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 81 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 177 | Proton acceptorBy similarity | 1 | |
Binding sitei | 455 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 544 | Proton acceptorBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 55 – 63 | ATPPROSITE-ProRule annotation | 9 | |
Nucleotide bindingi | 432 – 440 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB
- magnesium ion binding Source: InterPro
- protein kinase activity Source: UniProtKB
- protein serine/threonine kinase activity Source: UniProtKB
GO - Biological processi
- axon guidance Source: Reactome
- epidermal growth factor receptor signaling pathway Source: UniProtKB
- histone H2A-S1 phosphorylation Source: UniProtKB
- histone H3-S10 phosphorylation Source: UniProtKB
- histone H3-S28 phosphorylation Source: UniProtKB
- histone phosphorylation Source: UniProtKB
- inflammatory response Source: UniProtKB-KW
- interleukin-1-mediated signaling pathway Source: BHF-UCL
- intracellular signal transduction Source: UniProtKB
- negative regulation of cytokine production Source: UniProtKB
- negative regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of CREB transcription factor activity Source: UniProtKB
- positive regulation of histone acetylation Source: BHF-UCL
- positive regulation of histone phosphorylation Source: BHF-UCL
- positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: BHF-UCL
- protein phosphorylation Source: UniProtKB
- regulation of transcription, DNA-templated Source: UniProtKB
- stimulatory C-type lectin receptor signaling pathway Source: Reactome
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Biological process | Inflammatory response, Stress response |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-HSA-198753. ERK/MAPK targets. R-HSA-199920. CREB phosphorylation. R-HSA-375165. NCAM signaling for neurite out-growth. R-HSA-437239. Recycling pathway of L1. R-HSA-5621575. CD209 (DC-SIGN) signaling. |
SABIO-RKi | O75582. |
SignaLinki | O75582. |
SIGNORi | O75582. |
Names & Taxonomyi
Protein namesi | Recommended name: Ribosomal protein S6 kinase alpha-5 (EC:2.7.11.1)Short name: S6K-alpha-5 Alternative name(s): 90 kDa ribosomal protein S6 kinase 5 Nuclear mitogen- and stress-activated protein kinase 1 RSK-like protein kinase Short name: RSKL |
Gene namesi | Name:RPS6KA5 Synonyms:MSK1 |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000100784.9. |
HGNCi | HGNC:10434. RPS6KA5. |
MIMi | 603607. gene. |
neXtProti | NX_O75582. |
Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 195 | D → A: Loss of kinase activity. 1 Publication | 1 | |
Mutagenesisi | 212 | S → A: Inactivates the N-terminal kinase domain. 1 Publication | 1 | |
Mutagenesisi | 360 | S → A: Decreases kinase activity by 60% in response to PMA and UV-C. 1 Publication | 1 | |
Mutagenesisi | 376 | S → A: Loss of kinase activity, and decreases the phosphorylation of S-360 and T-581. 1 Publication | 1 | |
Mutagenesisi | 565 | D → A: Loss of kinase activity. 1 Publication | 1 | |
Mutagenesisi | 581 | T → A: Loss of kinase activity, and blocks phosphorylation of S-212; S-376 and S-381 in response to PMA and UV-C. 1 Publication | 1 | |
Mutagenesisi | 700 | T → A or D: Strongly reduces phosphorylation of T-581 in response to PMA and UV-C. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 9252. |
OpenTargetsi | ENSG00000100784. |
PharmGKBi | PA34849. |
Chemistry databases
ChEMBLi | CHEMBL4237. |
GuidetoPHARMACOLOGYi | 1523. |
Polymorphism and mutation databases
BioMutai | RPS6KA5. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000086207 | 1 – 802 | Ribosomal protein S6 kinase alpha-5Add BLAST | 802 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 212 | Phosphoserine; by autocatalysis1 Publication | 1 | |
Modified residuei | 360 | Phosphoserine; by MAPK1, MAPK3 and MAPK141 Publication | 1 | |
Modified residuei | 376 | Phosphoserine; by autocatalysisCombined sources1 Publication | 1 | |
Modified residuei | 381 | Phosphoserine; by autocatalysisCombined sources1 Publication | 1 | |
Modified residuei | 581 | Phosphothreonine; by MAPK1, MAPK3 and MAPK141 Publication | 1 | |
Modified residuei | 647 | Phosphoserine1 Publication | 1 | |
Modified residuei | 657 | Phosphoserine1 Publication | 1 | |
Modified residuei | 691 | PhosphoserineBy similarity | 1 | |
Modified residuei | 695 | Phosphoserine1 Publication | 1 | |
Modified residuei | 700 | Phosphothreonine; by MAPK1, MAPK3 and MAPK141 Publication | 1 | |
Modified residuei | 750 | Phosphoserine; by autocatalysis1 Publication | 1 | |
Modified residuei | 752 | Phosphoserine; by autocatalysis1 Publication | 1 | |
Modified residuei | 758 | Phosphoserine; by autocatalysis1 Publication | 1 | |
Modified residuei | 798 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Ser-376 and Thr-581 phosphorylation is required for kinase activity. Ser-376 and Ser-212 are autophosphorylated by the C-terminal kinase domain, and their phosphorylation is essential for the catalytic activity of the N-terminal kinase domain. Phosphorylated at Ser-360, Thr-581 and Thr-700 by MAPK1/ERK2, MAPK3/ERK1 and MAPK14/p38-alpha. Autophosphorylated at Ser-750, Ser-752 and Ser-758 by the N-terminal kinase domain.2 Publications
Ubiquitinated.1 Publication
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
EPDi | O75582. |
MaxQBi | O75582. |
PaxDbi | O75582. |
PeptideAtlasi | O75582. |
PRIDEi | O75582. |
PTM databases
iPTMneti | O75582. |
PhosphoSitePlusi | O75582. |
Expressioni
Tissue specificityi
Widely expressed with high levels in heart, brain and placenta. Less abundant in lung, kidney and liver.2 Publications
Gene expression databases
Bgeei | ENSG00000100784. |
CleanExi | HS_RPS6KA5. |
ExpressionAtlasi | O75582. baseline and differential. |
Genevisiblei | O75582. HS. |
Organism-specific databases
HPAi | CAB025458. HPA001274. HPA001780. |
Interactioni
Subunit structurei
Forms a complex with either MAPK1/ERK2 or MAPK3/ERK1 in quiescent cells which transiently dissociates following mitogenic stimulation. Also associates with MAPK14/p38-alpha. Activated RPS6KA5 associates with and phosphorylates the NF-kappa-B p65 subunit RELA. Interacts with CREBBP and EP300.2 Publications
Binary interactionsi
Protein-protein interaction databases
BioGridi | 114676. 55 interactors. |
DIPi | DIP-30894N. |
ELMi | O75582. |
IntActi | O75582. 37 interactors. |
MINTi | O75582. |
STRINGi | 9606.ENSP00000261991. |
Chemistry databases
BindingDBi | O75582. |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more detailsFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Beta strandi | 26 – 31 | Combined sources | 6 | |
Helixi | 46 – 48 | Combined sources | 3 | |
Beta strandi | 49 – 57 | Combined sources | 9 | |
Turni | 58 – 60 | Combined sources | 3 | |
Beta strandi | 61 – 68 | Combined sources | 8 | |
Turni | 72 – 75 | Combined sources | 4 | |
Beta strandi | 77 – 94 | Combined sources | 18 | |
Helixi | 95 – 97 | Combined sources | 3 | |
Helixi | 101 – 109 | Combined sources | 9 | |
Beta strandi | 117 – 123 | Combined sources | 7 | |
Beta strandi | 126 – 131 | Combined sources | 6 | |
Helixi | 139 – 146 | Combined sources | 8 | |
Helixi | 151 – 170 | Combined sources | 20 | |
Helixi | 180 – 182 | Combined sources | 3 | |
Beta strandi | 183 – 185 | Combined sources | 3 | |
Beta strandi | 191 – 194 | Combined sources | 4 | |
Beta strandi | 196 – 201 | Combined sources | 6 | |
Helixi | 204 – 210 | Combined sources | 7 | |
Helixi | 212 – 214 | Combined sources | 3 | |
Helixi | 222 – 225 | Combined sources | 4 | |
Helixi | 235 – 250 | Combined sources | 16 | |
Helixi | 264 – 273 | Combined sources | 10 | |
Helixi | 284 – 293 | Combined sources | 10 | |
Helixi | 298 – 300 | Combined sources | 3 | |
Turni | 306 – 308 | Combined sources | 3 | |
Helixi | 309 – 313 | Combined sources | 5 | |
Helixi | 316 – 318 | Combined sources | 3 | |
Helixi | 323 – 327 | Combined sources | 5 | |
Helixi | 418 – 422 | Combined sources | 5 | |
Beta strandi | 423 – 425 | Combined sources | 3 | |
Beta strandi | 432 – 435 | Combined sources | 4 | |
Beta strandi | 438 – 445 | Combined sources | 8 | |
Turni | 446 – 448 | Combined sources | 3 | |
Beta strandi | 451 – 458 | Combined sources | 8 | |
Helixi | 459 – 461 | Combined sources | 3 | |
Helixi | 462 – 474 | Combined sources | 13 | |
Turni | 475 – 477 | Combined sources | 3 | |
Beta strandi | 484 – 489 | Combined sources | 6 | |
Beta strandi | 491 – 498 | Combined sources | 8 | |
Helixi | 506 – 512 | Combined sources | 7 | |
Helixi | 518 – 537 | Combined sources | 20 | |
Helixi | 547 – 549 | Combined sources | 3 | |
Beta strandi | 550 – 553 | Combined sources | 4 | |
Beta strandi | 560 – 563 | Combined sources | 4 | |
Helixi | 602 – 617 | Combined sources | 16 | |
Helixi | 634 – 641 | Combined sources | 8 | |
Turni | 642 – 644 | Combined sources | 3 | |
Helixi | 651 – 654 | Combined sources | 4 | |
Helixi | 658 – 668 | Combined sources | 11 | |
Turni | 672 – 674 | Combined sources | 3 | |
Turni | 678 – 680 | Combined sources | 3 | |
Helixi | 685 – 687 | Combined sources | 3 | |
Helixi | 700 – 728 | Combined sources | 29 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1VZO | X-ray | 1.80 | A | 2-348 | [»] | |
3KN5 | X-ray | 2.40 | A/B | 414-738 | [»] | |
3KN6 | X-ray | 2.00 | A/B | 414-738 | [»] | |
ProteinModelPortali | O75582. | |||||
SMRi | O75582. | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O75582. |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 49 – 318 | Protein kinase 1PROSITE-ProRule annotationAdd BLAST | 270 | |
Domaini | 319 – 387 | AGC-kinase C-terminalAdd BLAST | 69 | |
Domaini | 426 – 687 | Protein kinase 2PROSITE-ProRule annotationAdd BLAST | 262 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0598. Eukaryota. ENOG410XNPH. LUCA. |
GeneTreei | ENSGT00890000139324. |
HOGENOMi | HOG000233033. |
HOVERGENi | HBG108317. |
InParanoidi | O75582. |
KOi | K04445. |
OMAi | APSILFK. |
PhylomeDBi | O75582. |
TreeFami | TF313438. |
Family and domain databases
InterProi | View protein in InterPro IPR000961. AGC-kinase_C. IPR011009. Kinase-like_dom_sf. IPR017892. Pkinase_C. IPR000719. Prot_kinase_dom. IPR017441. Protein_kinase_ATP_BS. IPR016239. Ribosomal_S6_kinase_II. IPR008271. Ser/Thr_kinase_AS. |
Pfami | View protein in Pfam PF00069. Pkinase. 2 hits. PF00433. Pkinase_C. 1 hit. |
PIRSFi | PIRSF000606. Ribsml_S6_kin_2. 1 hit. |
SMARTi | View protein in SMART SM00133. S_TK_X. 1 hit. SM00220. S_TKc. 2 hits. |
SUPFAMi | SSF56112. SSF56112. 2 hits. |
PROSITEi | View protein in PROSITE PS51285. AGC_KINASE_CTER. 1 hit. PS00107. PROTEIN_KINASE_ATP. 2 hits. PS50011. PROTEIN_KINASE_DOM. 2 hits. PS00108. PROTEIN_KINASE_ST. 2 hits. |
s (3)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: O75582-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MEEEGGSSGG AAGTSADGGD GGEQLLTVKH ELRTANLTGH AEKVGIENFE
60 70 80 90 100
LLKVLGTGAY GKVFLVRKIS GHDTGKLYAM KVLKKATIVQ KAKTTEHTRT
110 120 130 140 150
ERQVLEHIRQ SPFLVTLHYA FQTETKLHLI LDYINGGELF THLSQRERFT
160 170 180 190 200
EHEVQIYVGE IVLALEHLHK LGIIYRDIKL ENILLDSNGH VVLTDFGLSK
210 220 230 240 250
EFVADETERA YSFCGTIEYM APDIVRGGDS GHDKAVDWWS LGVLMYELLT
260 270 280 290 300
GASPFTVDGE KNSQAEISRR ILKSEPPYPQ EMSALAKDLI QRLLMKDPKK
310 320 330 340 350
RLGCGPRDAD EIKEHLFFQK INWDDLAAKK VPAPFKPVIR DELDVSNFAE
360 370 380 390 400
EFTEMDPTYS PAALPQSSEK LFQGYSFVAP SILFKRNAAV IDPLQFHMGV
410 420 430 440 450
ERPGVTNVAR SAMMKDSPFY QHYDLDLKDK PLGEGSFSIC RKCVHKKSNQ
460 470 480 490 500
AFAVKIISKR MEANTQKEIT ALKLCEGHPN IVKLHEVFHD QLHTFLVMEL
510 520 530 540 550
LNGGELFERI KKKKHFSETE ASYIMRKLVS AVSHMHDVGV VHRDLKPENL
560 570 580 590 600
LFTDENDNLE IKIIDFGFAR LKPPDNQPLK TPCFTLHYAA PELLNQNGYD
610 620 630 640 650
ESCDLWSLGV ILYTMLSGQV PFQSHDRSLT CTSAVEIMKK IKKGDFSFEG
660 670 680 690 700
EAWKNVSQEA KDLIQGLLTV DPNKRLKMSG LRYNEWLQDG SQLSSNPLMT
710 720 730 740 750
PDILGSSGAA VHTCVKATFH AFNKYKREGF CLQNVDKAPL AKRRKMKKTS
760 770 780 790 800
TSTETRSSSS ESSHSSSSHS HGKTTPTKTL QPSNPADSNN PETLFQFSDS
VA
Sequence cautioni
The sequence AAC69577 differs from that shown. Reason: Frameshift at several positions.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 452 – 453 | FA → LQ in AAC69577 (PubMed:10702687).Curated | 2 | |
Sequence conflicti | 532 | V → L in AAC69577 (PubMed:10702687).Curated | 1 | |
Sequence conflicti | 538 | V → L in AAC69577 (PubMed:10702687).Curated | 1 | |
Sequence conflicti | 757 – 758 | SS → RG in AAC69577 (PubMed:10702687).Curated | 2 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_051634 | 190 | H → R. Corresponds to variant dbSNP:rs34699345Ensembl. | 1 | |
Natural variantiVAR_040634 | 554 | D → N1 PublicationCorresponds to variant dbSNP:rs55911249Ensembl. | 1 | |
Natural variantiVAR_040635 | 574 | P → L1 PublicationCorresponds to variant dbSNP:rs34604933Ensembl. | 1 | |
Natural variantiVAR_040636 | 599 | Y → C1 PublicationCorresponds to variant dbSNP:rs55968863Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_057410 | 1 – 79 | Missing in isoform 3. 1 PublicationAdd BLAST | 79 | |
Alternative sequenceiVSP_041837 | 549 | N → V in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_041838 | 550 – 802 | Missing in isoform 2. 1 PublicationAdd BLAST | 253 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF074393 mRNA. Translation: AAC31171.1. AF080000 mRNA. Translation: AAD23915.1. AF090421 mRNA. Translation: AAC69577.1. Frameshift. AK295266 mRNA. Translation: BAH12021.1. AL121784 Genomic DNA. No translation available. AL133454 Genomic DNA. No translation available. AL159191 Genomic DNA. No translation available. BC017187 mRNA. Translation: AAH17187.1. |
CCDSi | CCDS45149.1. [O75582-2] CCDS81839.1. [O75582-3] CCDS9893.1. [O75582-1] |
PIRi | T13149. |
RefSeqi | NP_001309164.1. NM_001322235.1. [O75582-3] NP_001309166.1. NM_001322237.1. [O75582-3] NP_004746.2. NM_004755.3. [O75582-1] NP_872198.1. NM_182398.2. [O75582-2] |
UniGenei | Hs.510225. |
Genome annotation databases
Ensembli | ENST00000418736; ENSP00000402787; ENSG00000100784. [O75582-2] ENST00000536315; ENSP00000442803; ENSG00000100784. [O75582-3] ENST00000614987; ENSP00000479667; ENSG00000100784. [O75582-1] |
GeneIDi | 9252. |
KEGGi | hsa:9252. |
UCSCi | uc001xys.4. human. [O75582-1] uc010twi.3. human. |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Entry informationi
Entry namei | KS6A5_HUMAN | |
Accessioni | O75582Primary (citable) accession number: O75582 Secondary accession number(s): B7Z2Y5, O95316, Q96AF7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 24, 2003 |
Last sequence update: | November 1, 1998 | |
Last modified: | March 28, 2018 | |
This is version 184 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |