##gff-version 3 O75581 UniProtKB Signal peptide 1 19 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 O75581 UniProtKB Chain 20 1613 . . . ID=PRO_0000017330;Note=Low-density lipoprotein receptor-related protein 6 O75581 UniProtKB Topological domain 20 1370 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 O75581 UniProtKB Transmembrane 1371 1393 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 O75581 UniProtKB Topological domain 1394 1613 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 O75581 UniProtKB Repeat 63 106 . . . Note=LDL-receptor class B 1 O75581 UniProtKB Repeat 107 149 . . . Note=LDL-receptor class B 2 O75581 UniProtKB Repeat 150 193 . . . Note=LDL-receptor class B 3 O75581 UniProtKB Repeat 194 236 . . . Note=LDL-receptor class B 4 O75581 UniProtKB Repeat 237 276 . . . Note=LDL-receptor class B 5 O75581 UniProtKB Domain 282 324 . . . Note=EGF-like 1 O75581 UniProtKB Repeat 372 414 . . . Note=LDL-receptor class B 6 O75581 UniProtKB Repeat 415 457 . . . Note=LDL-receptor class B 7 O75581 UniProtKB Repeat 458 501 . . . Note=LDL-receptor class B 8 O75581 UniProtKB Repeat 502 542 . . . Note=LDL-receptor class B 9 O75581 UniProtKB Repeat 543 584 . . . Note=LDL-receptor class B 10 O75581 UniProtKB Domain 588 628 . . . Note=EGF-like 2 O75581 UniProtKB Repeat 674 716 . . . Note=LDL-receptor class B 11 O75581 UniProtKB Repeat 717 759 . . . Note=LDL-receptor class B 12 O75581 UniProtKB Repeat 760 802 . . . Note=LDL-receptor class B 13 O75581 UniProtKB Repeat 803 842 . . . Note=LDL-receptor class B 14 O75581 UniProtKB Repeat 843 885 . . . Note=LDL-receptor class B 15 O75581 UniProtKB Domain 889 930 . . . Note=EGF-like 3 O75581 UniProtKB Repeat 977 1025 . . . Note=LDL-receptor class B 16 O75581 UniProtKB Repeat 1026 1068 . . . Note=LDL-receptor class B 17 O75581 UniProtKB Repeat 1069 1113 . . . Note=LDL-receptor class B 18 O75581 UniProtKB Repeat 1114 1156 . . . Note=LDL-receptor class B 19 O75581 UniProtKB Repeat 1157 1198 . . . Note=LDL-receptor class B 20 O75581 UniProtKB Domain 1203 1244 . . . Note=EGF-like 4 O75581 UniProtKB Domain 1248 1286 . . . Note=LDL-receptor class A 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124 O75581 UniProtKB Domain 1287 1323 . . . Note=LDL-receptor class A 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124 O75581 UniProtKB Domain 1325 1361 . . . Note=LDL-receptor class A 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124 O75581 UniProtKB Region 20 275 . . . Note=Beta-propeller 1 O75581 UniProtKB Region 328 589 . . . Note=Beta-propeller 2 O75581 UniProtKB Region 631 890 . . . Note=Beta-propeller 3 O75581 UniProtKB Region 933 1202 . . . Note=Beta-propeller 4 O75581 UniProtKB Region 1556 1613 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O75581 UniProtKB Motif 1487 1493 . . . Note=PPPSP motif A O75581 UniProtKB Motif 1527 1534 . . . Note=PPPSP motif B O75581 UniProtKB Motif 1568 1575 . . . Note=PPPSP motif C O75581 UniProtKB Motif 1588 1593 . . . Note=PPPSP motif D O75581 UniProtKB Motif 1603 1610 . . . Note=PPPSP motif E O75581 UniProtKB Modified residue 1420 1420 . . . Note=Phosphoserine%3B by CK1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16513652;Dbxref=PMID:16513652 O75581 UniProtKB Modified residue 1430 1430 . . . Note=Phosphoserine%3B by CK1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16513652;Dbxref=PMID:16513652 O75581 UniProtKB Modified residue 1479 1479 . . . Note=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17569865;Dbxref=PMID:17569865 O75581 UniProtKB Modified residue 1490 1490 . . . Note=Phosphoserine%3B by CDK14%2C GRK5 and GRK6;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:16341017,ECO:0000269|PubMed:17698587,ECO:0000269|PubMed:18762581,ECO:0000269|PubMed:19801552,ECO:0000269|PubMed:20059949,ECO:0000269|PubMed:25331957,ECO:0000269|PubMed:27821587,ECO:0007744|PubMed:23186163;Dbxref=PMID:16341017,PMID:17698587,PMID:18762581,PMID:19801552,PMID:20059949,PMID:23186163,PMID:25331957,PMID:27821587 O75581 UniProtKB Modified residue 1493 1493 . . . Note=Phosphothreonine%3B by CK1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16341017;Dbxref=PMID:16341017 O75581 UniProtKB Lipidation 1394 1394 . . . Note=S-palmitoyl cysteine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18378904;Dbxref=PMID:18378904 O75581 UniProtKB Lipidation 1399 1399 . . . Note=S-palmitoyl cysteine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18378904;Dbxref=PMID:18378904 O75581 UniProtKB Glycosylation 42 42 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 O75581 UniProtKB Glycosylation 81 81 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 O75581 UniProtKB Glycosylation 281 281 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 O75581 UniProtKB Glycosylation 433 433 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 O75581 UniProtKB Glycosylation 486 486 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 O75581 UniProtKB Glycosylation 692 692 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22000856;Dbxref=PMID:22000856 O75581 UniProtKB Glycosylation 859 859 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22000856;Dbxref=PMID:22000856 O75581 UniProtKB Glycosylation 865 865 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22000856;Dbxref=PMID:22000856 O75581 UniProtKB Glycosylation 926 926 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22000856;Dbxref=PMID:22000856 O75581 UniProtKB Glycosylation 1039 1039 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22000856;Dbxref=PMID:22000856 O75581 UniProtKB Disulfide bond 286 297 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124 O75581 UniProtKB Disulfide bond 293 308 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124 O75581 UniProtKB Disulfide bond 310 323 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124 O75581 UniProtKB Disulfide bond 592 603 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124 O75581 UniProtKB Disulfide bond 599 612 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124 O75581 UniProtKB Disulfide bond 614 627 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124 O75581 UniProtKB Disulfide bond 893 904 . . . Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00124,ECO:0000269|PubMed:22000856;Dbxref=PMID:22000856 O75581 UniProtKB Disulfide bond 900 914 . . . Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00124,ECO:0000269|PubMed:22000856;Dbxref=PMID:22000856 O75581 UniProtKB Disulfide bond 916 929 . . . Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00124,ECO:0000269|PubMed:22000856;Dbxref=PMID:22000856 O75581 UniProtKB Disulfide bond 1207 1218 . . . Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00124,ECO:0000269|PubMed:22000856;Dbxref=PMID:22000856 O75581 UniProtKB Disulfide bond 1214 1228 . . . Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00124,ECO:0000269|PubMed:22000856;Dbxref=PMID:22000856 O75581 UniProtKB Disulfide bond 1230 1243 . . . Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00124,ECO:0000269|PubMed:22000856;Dbxref=PMID:22000856 O75581 UniProtKB Disulfide bond 1249 1263 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124 O75581 UniProtKB Disulfide bond 1256 1276 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124 O75581 UniProtKB Disulfide bond 1270 1285 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124 O75581 UniProtKB Disulfide bond 1288 1300 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124 O75581 UniProtKB Disulfide bond 1295 1313 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124 O75581 UniProtKB Disulfide bond 1307 1322 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124 O75581 UniProtKB Disulfide bond 1326 1338 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124 O75581 UniProtKB Disulfide bond 1333 1351 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124 O75581 UniProtKB Disulfide bond 1345 1360 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124 O75581 UniProtKB Cross-link 1403 1403 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18378904;Dbxref=PMID:18378904 O75581 UniProtKB Natural variant 19 19 . . . ID=VAR_076207;Note=In STHAG7%3B impairs Wnt signaling%3B prevents transport to plasma membrane location. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26387593;Dbxref=dbSNP:rs864309648,PMID:26387593 O75581 UniProtKB Natural variant 360 360 . . . ID=VAR_076208;Note=In ADCAD2. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23703864;Dbxref=dbSNP:rs141212743,PMID:23703864 O75581 UniProtKB Natural variant 433 433 . . . ID=VAR_076209;Note=In ADCAD2. N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23703864;Dbxref=dbSNP:rs397515473,PMID:23703864 O75581 UniProtKB Natural variant 473 473 . . . ID=VAR_076210;Note=In ADCAD2%3B impairs Wnt signaling. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23703864;Dbxref=dbSNP:rs397515474,PMID:23703864 O75581 UniProtKB Natural variant 483 483 . . . ID=VAR_030349;Note=V->I;Dbxref=dbSNP:rs7975614 O75581 UniProtKB Natural variant 611 611 . . . ID=VAR_034701;Note=In ADCAD2%3B impairs Wnt signaling in vitro. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17332414;Dbxref=dbSNP:rs121918313,PMID:17332414 O75581 UniProtKB Natural variant 817 817 . . . ID=VAR_030350;Note=S->C;Dbxref=dbSNP:rs2302686 O75581 UniProtKB Natural variant 1062 1062 . . . ID=VAR_024520;Note=V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9704021;Dbxref=dbSNP:rs2302685,PMID:9704021 O75581 UniProtKB Natural variant 1401 1401 . . . ID=VAR_034702;Note=R->H;Dbxref=dbSNP:rs34815107 O75581 UniProtKB Natural variant 1415 1415 . . . ID=VAR_083431;Note=Found in a patient with congenital hydrocephalus%3B uncertain significance. V->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29983323;Dbxref=PMID:29983323 O75581 UniProtKB Mutagenesis 1394 1394 . . . Note=Some reduction of palmitoylation%2C little change in plasma membrane location in the presence of MESD nor in Wnt-signaling activity. Completely abolishes palmitoylation%2C no plasma membrane location%2C greatly reduced Wnt-signaling activity but no effect on ubiquitination%3B when associated with A-1399. Exhibits full Wnt-signaling activity and no change in plasma membrane location%3B when associated with A-1399 and R-1403. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18378904;Dbxref=PMID:18378904 O75581 UniProtKB Mutagenesis 1399 1399 . . . Note=Some reduction of palmitoylation%2C and little change in plasma membrane location in the presence of MESD nor in Wnt-signaling activity. Completely abolishes palmitoylation%2C no plasma membrane location%2C greatly reduced Wnt-signaling activity but no effect on ubiquitination%3B when associated with A-1394. Exhibits full Wnt-signaling activity and no change in plasma membrane location in the in presence of MESD%3B when associated with A-1394 and R-1403. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18378904;Dbxref=PMID:18378904 O75581 UniProtKB Mutagenesis 1403 1403 . . . Note=Abolishes ubiquitination%2C no change in plasma membrane location in the presence of MESD but greatly reduced Wnt-signaling activity. Exhibits full Wnt-signaling activity and no change in plasma membrane location%3B when associated with A-1394 and A-1399. K->R O75581 UniProtKB Mutagenesis 1420 1420 . . . Note=Enhanced AXIN1 binding and increased beta-catenin activity by 2.2-fold. Further enhanced AXIN1 binding and increases beta-catenin activity by 3.3-fold%3B when associated with A-1430. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16513652;Dbxref=PMID:16513652 O75581 UniProtKB Mutagenesis 1430 1430 . . . Note=Enhanced AXIN1 binding. Further enhanced AXIN1 binding and increases beta-catenin activity by 3.3-fold%3B when associated with A-1420. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16513652;Dbxref=PMID:16513652 O75581 UniProtKB Mutagenesis 1485 1485 . . . Note=No change in the phosphorylation state of PPPSP motif. Some reduction in Wnt/beta-catenin signaling. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18362152;Dbxref=PMID:18362152 O75581 UniProtKB Mutagenesis 1486 1486 . . . Note=No change in the phosphorylation state of PPPSP motif. Increased Wnt/beta-catenin signaling. N->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18362152;Dbxref=PMID:18362152 O75581 UniProtKB Mutagenesis 1487 1487 . . . Note=No change in the phosphorylation state of PPPSP motif A. Greatly reduced Wnt/beta-catenin signaling. P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18362152;Dbxref=PMID:18362152 O75581 UniProtKB Mutagenesis 1487 1487 . . . Note=No change in the phosphorylation state of PPPSP motif A. Greatly reduced Wnt/beta-catenin signaling. P->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18362152;Dbxref=PMID:18362152 O75581 UniProtKB Mutagenesis 1488 1488 . . . Note=No change in the phosphorylation state of PPPSP motif A. Greatly reduced Wnt/beta-catenin signaling. P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18362152;Dbxref=PMID:18362152 O75581 UniProtKB Mutagenesis 1489 1489 . . . Note=No change in the phosphorylation state of PPPSP motif A. Greatly reduced Wnt/beta-catenin signaling. P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18362152;Dbxref=PMID:18362152 O75581 UniProtKB Mutagenesis 1490 1490 . . . Note=Greatly reduced phosphorylation of PPPSP motif A. Greatly reduced Wnt/beta-catenin signaling. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18362152;Dbxref=PMID:18362152 O75581 UniProtKB Mutagenesis 1490 1490 . . . Note=Some loss of phosphorylation of PPPSP motif A. Little reduction in Wnt/beta-catenin signaling. S->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18362152;Dbxref=PMID:18362152 O75581 UniProtKB Mutagenesis 1491 1491 . . . Note=Greatly reduced phosphorylation of PPPSP motif A. Greatly reduced Wnt/beta-catenin signaling. P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18362152;Dbxref=PMID:18362152 O75581 UniProtKB Mutagenesis 1492 1492 . . . Note=No change in the phosphorylation state of PPPSP motif A. Greatly reduced Wnt/beta-catenin signaling. A->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18362152;Dbxref=PMID:18362152 O75581 UniProtKB Mutagenesis 1493 1493 . . . Note=No change in the phosphorylation state of PPPSP motif A. Greatly reduced Wnt/beta-catenin signaling. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18362152;Dbxref=PMID:18362152 O75581 UniProtKB Mutagenesis 1494 1494 . . . Note=No change in the phosphorylation state of PPPSP motif A. Little reduction of Wnt/beta-catenin signaling. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18362152;Dbxref=PMID:18362152 O75581 UniProtKB Mutagenesis 1495 1495 . . . Note=No change in the phosphorylation state of PPPSP motif. No reduction of Wnt/beta-catenin signaling. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18362152;Dbxref=PMID:18362152 O75581 UniProtKB Mutagenesis 1529 1529 . . . Note=No effect on the phosphorylation state of PPPSP motif B. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18362152;Dbxref=PMID:18362152 O75581 UniProtKB Mutagenesis 1530 1530 . . . Note=Abolishes phosphorylation of PPPSP motif B. Reduced Wnt/beta-catenin signaling. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18362152;Dbxref=PMID:18362152 O75581 UniProtKB Mutagenesis 1531 1531 . . . Note=Abolishes phosphorylation of PPPSP motif B. Reduced Wnt/beta-catenin signaling. P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18362152;Dbxref=PMID:18362152 O75581 UniProtKB Mutagenesis 1572 1572 . . . Note=Abolishes Wnt/beta-catenin signaling. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18362152;Dbxref=PMID:18362152 O75581 UniProtKB Mutagenesis 1590 1590 . . . Note=Abolishes Wnt/beta-catenin signaling. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18362152;Dbxref=PMID:18362152 O75581 UniProtKB Mutagenesis 1607 1607 . . . Note=Abolishes Wnt/beta-catenin signaling. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18362152;Dbxref=PMID:18362152 O75581 UniProtKB Beta strand 22 26 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3SOV O75581 UniProtKB Beta strand 28 35 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3SOV O75581 UniProtKB Turn 37 40 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8FFE O75581 UniProtKB Beta strand 44 59 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3SOV O75581 UniProtKB Helix 60 62 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3SOV O75581 UniProtKB Beta strand 64 69 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3SOV O75581 UniProtKB Turn 70 73 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3SOV O75581 UniProtKB Beta strand 74 79 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3SOV O75581 UniProtKB Beta strand 82 84 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3SOV O75581 UniProtKB Beta strand 88 92 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3SOV O75581 UniProtKB Beta strand 99 103 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3SOV O75581 UniProtKB Turn 104 107 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3SOV O75581 UniProtKB Beta strand 108 113 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3SOV O75581 UniProtKB Turn 114 117 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3SOV O75581 UniProtKB Beta strand 118 123 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3SOV O75581 UniProtKB Beta strand 130 133 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3SOV O75581 UniProtKB Beta strand 138 146 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3SOV O75581 UniProtKB Helix 147 149 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3SOV O75581 UniProtKB Beta strand 151 156 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3SOV O75581 UniProtKB Beta strand 158 160 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3SOV O75581 UniProtKB Beta strand 162 167 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3SOV O75581 UniProtKB Beta strand 174 177 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3SOV O75581 UniProtKB Beta strand 184 190 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3SOV O75581 UniProtKB Turn 191 194 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3SOV O75581 UniProtKB Beta strand 195 200 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3SOV O75581 UniProtKB Turn 201 204 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3SOV O75581 UniProtKB Beta strand 205 210 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3SOV O75581 UniProtKB Beta strand 217 220 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3SOV O75581 UniProtKB Beta strand 227 233 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3SOV O75581 UniProtKB Beta strand 236 241 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3SOV O75581 UniProtKB Turn 242 245 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3SOV O75581 UniProtKB Beta strand 246 251 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3SOV O75581 UniProtKB Turn 252 254 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3SOV O75581 UniProtKB Beta strand 259 262 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3SOV O75581 UniProtKB Beta strand 271 274 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3SOV O75581 UniProtKB Helix 276 278 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3SOV O75581 UniProtKB Turn 285 289 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3SOV O75581 UniProtKB Helix 290 292 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3SOV O75581 UniProtKB Beta strand 294 299 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3SOV O75581 UniProtKB Beta strand 305 309 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3SOV O75581 UniProtKB Beta strand 328 337 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8FFE O75581 UniProtKB Beta strand 339 346 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8FFE O75581 UniProtKB Beta strand 351 353 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8FFE O75581 UniProtKB Beta strand 362 368 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8FFE O75581 UniProtKB Turn 369 372 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8FFE O75581 UniProtKB Beta strand 373 378 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8FFE O75581 UniProtKB Turn 379 382 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8FFE O75581 UniProtKB Beta strand 383 387 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8FFE O75581 UniProtKB Beta strand 389 391 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4DG6 O75581 UniProtKB Beta strand 395 398 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8FFE O75581 UniProtKB Beta strand 407 411 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8FFE O75581 UniProtKB Turn 412 415 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8FFE O75581 UniProtKB Beta strand 416 421 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8FFE O75581 UniProtKB Turn 422 425 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8FFE O75581 UniProtKB Beta strand 426 431 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8FFE O75581 UniProtKB Beta strand 438 441 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8FFE O75581 UniProtKB Beta strand 446 454 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8FFE O75581 UniProtKB Turn 455 458 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8FFE O75581 UniProtKB Beta strand 459 464 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8FFE O75581 UniProtKB Beta strand 466 468 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8FFE O75581 UniProtKB Beta strand 470 475 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8FFE O75581 UniProtKB Beta strand 482 485 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8FFE O75581 UniProtKB Beta strand 492 498 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8FFE O75581 UniProtKB Turn 499 502 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8FFE O75581 UniProtKB Beta strand 503 508 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8FFE O75581 UniProtKB Turn 509 512 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8FFE O75581 UniProtKB Beta strand 513 518 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8FFE O75581 UniProtKB Beta strand 525 528 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8FFE O75581 UniProtKB Beta strand 535 541 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8FFE O75581 UniProtKB Beta strand 544 549 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8FFE O75581 UniProtKB Turn 550 553 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8FFE O75581 UniProtKB Beta strand 554 559 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8FFE O75581 UniProtKB Turn 560 562 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8FFE O75581 UniProtKB Beta strand 565 569 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8FFE O75581 UniProtKB Beta strand 575 584 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8FFE O75581 UniProtKB Helix 591 593 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8FFE O75581 UniProtKB Helix 595 598 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8FFE O75581 UniProtKB Beta strand 600 604 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8FFE O75581 UniProtKB Beta strand 611 613 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8FFE O75581 UniProtKB Beta strand 633 638 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Beta strand 641 648 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Beta strand 653 655 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Beta strand 664 670 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Turn 671 674 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Beta strand 675 680 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Turn 681 684 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Beta strand 685 690 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Beta strand 697 700 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Beta strand 709 713 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Turn 714 717 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Beta strand 718 723 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Turn 724 727 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Beta strand 728 733 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Beta strand 740 743 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Beta strand 750 756 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Turn 757 760 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Beta strand 761 766 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Beta strand 768 770 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Beta strand 772 777 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Beta strand 784 787 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Beta strand 791 799 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Turn 800 803 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Beta strand 804 809 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Turn 810 813 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Beta strand 814 819 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Beta strand 826 830 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Beta strand 835 841 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Beta strand 844 849 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Turn 850 853 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Beta strand 854 859 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Turn 860 862 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Beta strand 867 870 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Beta strand 878 882 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Helix 884 886 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Turn 892 896 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Helix 897 899 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Beta strand 901 907 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Turn 908 910 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Beta strand 911 915 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Beta strand 933 940 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Beta strand 943 947 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Beta strand 967 973 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Turn 974 977 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Beta strand 978 983 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Turn 984 987 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Beta strand 988 993 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Beta strand 1000 1003 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Beta strand 1016 1022 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Turn 1023 1026 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Beta strand 1027 1032 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Turn 1033 1036 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Beta strand 1037 1042 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Beta strand 1047 1052 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Beta strand 1059 1065 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Turn 1066 1069 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Beta strand 1070 1077 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Beta strand 1080 1087 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Beta strand 1094 1097 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Beta strand 1104 1110 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Turn 1111 1114 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Beta strand 1115 1120 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Turn 1121 1124 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Beta strand 1125 1130 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Beta strand 1137 1140 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Beta strand 1147 1153 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Beta strand 1156 1161 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Turn 1162 1165 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Beta strand 1166 1171 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Beta strand 1174 1176 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Beta strand 1179 1182 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Beta strand 1188 1194 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Helix 1199 1204 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Turn 1206 1209 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Helix 1210 1213 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Beta strand 1215 1220 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Beta strand 1222 1224 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8DVM O75581 UniProtKB Beta strand 1226 1229 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Beta strand 1234 1236 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4A0P O75581 UniProtKB Beta strand 1240 1244 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8DVN