Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Integrin alpha-10

Gene

ITGA10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Integrin alpha-10/beta-1 is a receptor for collagen.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi494 – 502Sequence analysis9
Calcium bindingi558 – 566Sequence analysis9
Calcium bindingi620 – 628Sequence analysis9

GO - Molecular functioni

  • collagen binding Source: ProtInc
  • collagen binding involved in cell-matrix adhesion Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • cell-matrix adhesion Source: UniProtKB
  • extracellular matrix organization Source: Reactome
  • integrin-mediated signaling pathway Source: UniProtKB

Keywordsi

Molecular functionIntegrin, Receptor
Biological processCell adhesion
LigandCalcium, Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-216083 Integrin cell surface interactions
R-HSA-447041 CHL1 interactions
R-HSA-75892 Platelet Adhesion to exposed collagen
SIGNORiO75578

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin alpha-10
Gene namesi
Name:ITGA10
ORF Names:UNQ468/PRO827
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143127.12
HGNCiHGNC:6135 ITGA10
MIMi604042 gene
neXtProtiNX_O75578

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 1122ExtracellularSequence analysisAdd BLAST1100
Transmembranei1123 – 1145HelicalSequence analysisAdd BLAST23
Topological domaini1146 – 1167CytoplasmicSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi8515
OpenTargetsiENSG00000143127
PharmGKBiPA29936

Chemistry databases

ChEMBLiCHEMBL5882

Polymorphism and mutation databases

BioMutaiITGA10

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001631723 – 1167Integrin alpha-10Add BLAST1145

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi76 ↔ 86By similarity
Glycosylationi98N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi234N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi336N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi364N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi666 ↔ 675By similarity
Disulfide bondi681 ↔ 736By similarity
Glycosylationi733N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi763N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi789 ↔ 795By similarity
Glycosylationi839N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi921N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1011N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1018N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1039N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO75578
PeptideAtlasiO75578
PRIDEiO75578

PTM databases

iPTMnetiO75578
PhosphoSitePlusiO75578

Expressioni

Tissue specificityi

Widely expressed with highest expression in muscle and heart. Found in articular cartilage.

Gene expression databases

BgeeiENSG00000143127
CleanExiHS_ITGA10
GenevisibleiO75578 HS

Organism-specific databases

HPAiHPA064008

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. Alpha-10 associates with beta-1.

Protein-protein interaction databases

BioGridi114087, 1 interactor
CORUMiO75578
IntActiO75578, 1 interactor
STRINGi9606.ENSP00000358310

Structurei

3D structure databases

ProteinModelPortaliO75578
SMRiO75578
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati24 – 85FG-GAP 1PROSITE-ProRule annotationAdd BLAST62
Repeati95 – 154FG-GAP 2PROSITE-ProRule annotationAdd BLAST60
Domaini167 – 350VWFAPROSITE-ProRule annotationAdd BLAST184
Repeati361 – 412FG-GAP 3PROSITE-ProRule annotationAdd BLAST52
Repeati417 – 470FG-GAP 4PROSITE-ProRule annotationAdd BLAST54
Repeati472 – 534FG-GAP 5PROSITE-ProRule annotationAdd BLAST63
Repeati535 – 593FG-GAP 6PROSITE-ProRule annotationAdd BLAST59
Repeati597 – 657FG-GAP 7PROSITE-ProRule annotationAdd BLAST61

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1134 – 1140Poly-Leu7

Domaini

The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3637 Eukaryota
ENOG410XPVZ LUCA
GeneTreeiENSGT00760000118782
HOGENOMiHOG000059610
HOVERGENiHBG006185
InParanoidiO75578
KOiK06586
OMAiSSFGLEM
OrthoDBiEOG091G00QA
PhylomeDBiO75578
TreeFamiTF105391

Family and domain databases

Gene3Di2.130.10.130, 2 hits
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR013517 FG-GAP
IPR013519 Int_alpha_beta-p
IPR000413 Integrin_alpha
IPR013649 Integrin_alpha-2
IPR028994 Integrin_alpha_N
IPR032695 Integrin_dom_sf
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF01839 FG-GAP, 2 hits
PF08441 Integrin_alpha2, 1 hit
PF00092 VWA, 1 hit
PRINTSiPR01185 INTEGRINA
SMARTiView protein in SMART
SM00191 Int_alpha, 5 hits
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
SSF69179 SSF69179, 3 hits
PROSITEiView protein in PROSITE
PS51470 FG_GAP, 7 hits
PS50234 VWFA, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75578-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELPFVTHLF LPLVFLTGLC SPFNLDEHHP RLFPGPPEAE FGYSVLQHVG
60 70 80 90 100
GGQRWMLVGA PWDGPSGDRR GDVYRCPVGG AHNAPCAKGH LGDYQLGNSS
110 120 130 140 150
HPAVNMHLGM SLLETDGDGG FMACAPLWSR ACGSSVFSSG ICARVDASFQ
160 170 180 190 200
PQGSLAPTAQ RCPTYMDVVI VLDGSNSIYP WSEVQTFLRR LVGKLFIDPE
210 220 230 240 250
QIQVGLVQYG ESPVHEWSLG DFRTKEEVVR AAKNLSRREG RETKTAQAIM
260 270 280 290 300
VACTEGFSQS HGGRPEAARL LVVVTDGESH DGEELPAALK ACEAGRVTRY
310 320 330 340 350
GIAVLGHYLR RQRDPSSFLR EIRTIASDPD ERFFFNVTDE AALTDIVDAL
360 370 380 390 400
GDRIFGLEGS HAENESSFGL EMSQIGFSTH RLKDGILFGM VGAYDWGGSV
410 420 430 440 450
LWLEGGHRLF PPRMALEDEF PPALQNHAAY LGYSVSSMLL RGGRRLFLSG
460 470 480 490 500
APRFRHRGKV IAFQLKKDGA VRVAQSLQGE QIGSYFGSEL CPLDTDRDGT
510 520 530 540 550
TDVLLVAAPM FLGPQNKETG RVYVYLVGQQ SLLTLQGTLQ PEPPQDARFG
560 570 580 590 600
FAMGALPDLN QDGFADVAVG APLEDGHQGA LYLYHGTQSG VRPHPAQRIA
610 620 630 640 650
AASMPHALSY FGRSVDGRLD LDGDDLVDVA VGAQGAAILL SSRPIVHLTP
660 670 680 690 700
SLEVTPQAIS VVQRDCRRRG QEAVCLTAAL CFQVTSRTPG RWDHQFYMRF
710 720 730 740 750
TASLDEWTAG ARAAFDGSGQ RLSPRRLRLS VGNVTCEQLH FHVLDTSDYL
760 770 780 790 800
RPVALTVTFA LDNTTKPGPV LNEGSPTSIQ KLVPFSKDCG PDNECVTDLV
810 820 830 840 850
LQVNMDIRGS RKAPFVVRGG RRKVLVSTTL ENRKENAYNT SLSLIFSRNL
860 870 880 890 900
HLASLTPQRE SPIKVECAAP SAHARLCSVG HPVFQTGAKV TFLLEFEFSC
910 920 930 940 950
SSLLSQVFVK LTASSDSLER NGTLQDNTAQ TSAYIQYEPH LLFSSESTLH
960 970 980 990 1000
RYEVHPYGTL PVGPGPEFKT TLRVQNLGCY VVSGLIISAL LPAVAHGGNY
1010 1020 1030 1040 1050
FLSLSQVITN NASCIVQNLT EPPGPPVHPE ELQHTNRLNG SNTQCQVVRC
1060 1070 1080 1090 1100
HLGQLAKGTE VSVGLLRLVH NEFFRRAKFK SLTVVSTFEL GTEEGSVLQL
1110 1120 1130 1140 1150
TEASRWSESL LEVVQTRPIL ISLWILIGSV LGGLLLLALL VFCLWKLGFF
1160
AHKKIPEEEK REEKLEQ
Length:1,167
Mass (Da):127,602
Last modified:October 3, 2006 - v2
Checksum:i2F7FF938B4C0CBAC
GO
Isoform 2 (identifier: O75578-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     123-124: AC → VS
     125-1167: Missing.

Note: No experimental confirmation available.
Show »
Length:124
Mass (Da):13,352
Checksum:i562249D8A5B80416
GO
Isoform 3 (identifier: O75578-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     19-161: Missing.

Note: No experimental confirmation available.
Show »
Length:1,024
Mass (Da):112,544
Checksum:i4A10A1E07452B588
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti844L → I in AAC31952 (PubMed:9685391).Curated1
Sequence conflicti909V → G in AAC31952 (PubMed:9685391).Curated1
Sequence conflicti926D → E in AAC31952 (PubMed:9685391).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_027768381R → Q. Corresponds to variant dbSNP:rs6665210Ensembl.1
Natural variantiVAR_034026668R → W. Corresponds to variant dbSNP:rs36073645Ensembl.1
Natural variantiVAR_027769691R → H. Corresponds to variant dbSNP:rs2274618Ensembl.1
Natural variantiVAR_034027702A → T. Corresponds to variant dbSNP:rs35515885Ensembl.1
Natural variantiVAR_027770725R → Q. Corresponds to variant dbSNP:rs2274616Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05448319 – 161Missing in isoform 3. 1 PublicationAdd BLAST143
Alternative sequenceiVSP_013114123 – 124AC → VS in isoform 2. 1 Publication2
Alternative sequenceiVSP_013115125 – 1167Missing in isoform 2. 1 PublicationAdd BLAST1043

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF074015 mRNA Translation: AAC31952.1
AF112345 mRNA Translation: AAF21944.1
AF172723 Genomic DNA Translation: AAF61638.1
AY358325 mRNA Translation: AAQ88691.1
AK314255 mRNA Translation: BAG36921.1
AL160282 Genomic DNA No translation available.
CH471244 Genomic DNA Translation: EAW71425.1
BC140831 mRNA Translation: AAI40832.1
BC144637 mRNA Translation: AAI44638.1
CCDSiCCDS72869.1 [O75578-1]
CCDS76204.1 [O75578-3]
RefSeqiNP_001289969.1, NM_001303040.1
NP_001289970.1, NM_001303041.1 [O75578-3]
NP_003628.2, NM_003637.4 [O75578-1]
UniGeneiHs.158237

Genome annotation databases

EnsembliENST00000369304; ENSP00000358310; ENSG00000143127 [O75578-1]
ENST00000539363; ENSP00000439894; ENSG00000143127 [O75578-3]
GeneIDi8515
KEGGihsa:8515
UCSCiuc001eoa.4 human [O75578-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiITA10_HUMAN
AccessioniPrimary (citable) accession number: O75578
Secondary accession number(s): B2RAM4
, B2RTV5, Q6UXJ6, Q9UHZ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: October 3, 2006
Last modified: April 25, 2018
This is version 166 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health