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Protein

Integrin alpha-10

Gene

ITGA10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Integrin alpha-10/beta-1 is a receptor for collagen.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi494 – 502Sequence analysis9
Calcium bindingi558 – 566Sequence analysis9
Calcium bindingi620 – 628Sequence analysis9

GO - Molecular functioni

  • collagen binding Source: ProtInc
  • collagen binding involved in cell-matrix adhesion Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • cell-matrix adhesion Source: UniProtKB
  • extracellular matrix organization Source: Reactome
  • integrin-mediated signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Integrin, Receptor

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000143127-MONOMER.
ReactomeiR-HSA-216083. Integrin cell surface interactions.
R-HSA-447041. CHL1 interactions.
R-HSA-75892. Platelet Adhesion to exposed collagen.
SIGNORiO75578.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin alpha-10
Gene namesi
Name:ITGA10
ORF Names:UNQ468/PRO827
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:6135. ITGA10.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 1122ExtracellularSequence analysisAdd BLAST1100
Transmembranei1123 – 1145HelicalSequence analysisAdd BLAST23
Topological domaini1146 – 1167CytoplasmicSequence analysisAdd BLAST22

GO - Cellular componenti

  • integrin alpha10-beta1 complex Source: UniProtKB
  • integrin complex Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi8515.
OpenTargetsiENSG00000143127.
PharmGKBiPA29936.

Chemistry databases

ChEMBLiCHEMBL5882.

Polymorphism and mutation databases

BioMutaiITGA10.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001631723 – 1167Integrin alpha-10Add BLAST1145

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi76 ↔ 86By similarity
Glycosylationi98N-linked (GlcNAc...)Sequence analysis1
Glycosylationi234N-linked (GlcNAc...)Sequence analysis1
Glycosylationi336N-linked (GlcNAc...)Sequence analysis1
Glycosylationi364N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi666 ↔ 675By similarity
Disulfide bondi681 ↔ 736By similarity
Glycosylationi733N-linked (GlcNAc...)Sequence analysis1
Glycosylationi763N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi789 ↔ 795By similarity
Glycosylationi839N-linked (GlcNAc...)Sequence analysis1
Glycosylationi921N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1011N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1018N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1039N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO75578.
PeptideAtlasiO75578.
PRIDEiO75578.

PTM databases

iPTMnetiO75578.
PhosphoSitePlusiO75578.

Expressioni

Tissue specificityi

Widely expressed with highest expression in muscle and heart. Found in articular cartilage.

Gene expression databases

BgeeiENSG00000143127.
CleanExiHS_ITGA10.
GenevisibleiO75578. HS.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. Alpha-10 associates with beta-1.

GO - Molecular functioni

  • collagen binding Source: ProtInc
  • collagen binding involved in cell-matrix adhesion Source: UniProtKB

Protein-protein interaction databases

BioGridi114087. 1 interactor.
IntActiO75578. 1 interactor.
STRINGi9606.ENSP00000358310.

Structurei

3D structure databases

ProteinModelPortaliO75578.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati24 – 85FG-GAP 1PROSITE-ProRule annotationAdd BLAST62
Repeati95 – 154FG-GAP 2PROSITE-ProRule annotationAdd BLAST60
Domaini167 – 350VWFAPROSITE-ProRule annotationAdd BLAST184
Repeati361 – 412FG-GAP 3PROSITE-ProRule annotationAdd BLAST52
Repeati417 – 470FG-GAP 4PROSITE-ProRule annotationAdd BLAST54
Repeati472 – 534FG-GAP 5PROSITE-ProRule annotationAdd BLAST63
Repeati535 – 593FG-GAP 6PROSITE-ProRule annotationAdd BLAST59
Repeati597 – 657FG-GAP 7PROSITE-ProRule annotationAdd BLAST61

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1134 – 1140Poly-Leu7

Domaini

The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated
Contains 7 FG-GAP repeats.PROSITE-ProRule annotation
Contains 1 VWFA domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3637. Eukaryota.
ENOG410XPVZ. LUCA.
GeneTreeiENSGT00760000118782.
HOGENOMiHOG000059610.
HOVERGENiHBG006185.
InParanoidiO75578.
KOiK06586.
OMAiGPQNKET.
OrthoDBiEOG091G00QA.
PhylomeDBiO75578.
TreeFamiTF105391.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR032695. Integrin_dom.
IPR002035. VWF_A.
[Graphical view]
PfamiPF01839. FG-GAP. 2 hits.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 3 hits.
PROSITEiPS51470. FG_GAP. 7 hits.
PS50234. VWFA. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75578-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELPFVTHLF LPLVFLTGLC SPFNLDEHHP RLFPGPPEAE FGYSVLQHVG
60 70 80 90 100
GGQRWMLVGA PWDGPSGDRR GDVYRCPVGG AHNAPCAKGH LGDYQLGNSS
110 120 130 140 150
HPAVNMHLGM SLLETDGDGG FMACAPLWSR ACGSSVFSSG ICARVDASFQ
160 170 180 190 200
PQGSLAPTAQ RCPTYMDVVI VLDGSNSIYP WSEVQTFLRR LVGKLFIDPE
210 220 230 240 250
QIQVGLVQYG ESPVHEWSLG DFRTKEEVVR AAKNLSRREG RETKTAQAIM
260 270 280 290 300
VACTEGFSQS HGGRPEAARL LVVVTDGESH DGEELPAALK ACEAGRVTRY
310 320 330 340 350
GIAVLGHYLR RQRDPSSFLR EIRTIASDPD ERFFFNVTDE AALTDIVDAL
360 370 380 390 400
GDRIFGLEGS HAENESSFGL EMSQIGFSTH RLKDGILFGM VGAYDWGGSV
410 420 430 440 450
LWLEGGHRLF PPRMALEDEF PPALQNHAAY LGYSVSSMLL RGGRRLFLSG
460 470 480 490 500
APRFRHRGKV IAFQLKKDGA VRVAQSLQGE QIGSYFGSEL CPLDTDRDGT
510 520 530 540 550
TDVLLVAAPM FLGPQNKETG RVYVYLVGQQ SLLTLQGTLQ PEPPQDARFG
560 570 580 590 600
FAMGALPDLN QDGFADVAVG APLEDGHQGA LYLYHGTQSG VRPHPAQRIA
610 620 630 640 650
AASMPHALSY FGRSVDGRLD LDGDDLVDVA VGAQGAAILL SSRPIVHLTP
660 670 680 690 700
SLEVTPQAIS VVQRDCRRRG QEAVCLTAAL CFQVTSRTPG RWDHQFYMRF
710 720 730 740 750
TASLDEWTAG ARAAFDGSGQ RLSPRRLRLS VGNVTCEQLH FHVLDTSDYL
760 770 780 790 800
RPVALTVTFA LDNTTKPGPV LNEGSPTSIQ KLVPFSKDCG PDNECVTDLV
810 820 830 840 850
LQVNMDIRGS RKAPFVVRGG RRKVLVSTTL ENRKENAYNT SLSLIFSRNL
860 870 880 890 900
HLASLTPQRE SPIKVECAAP SAHARLCSVG HPVFQTGAKV TFLLEFEFSC
910 920 930 940 950
SSLLSQVFVK LTASSDSLER NGTLQDNTAQ TSAYIQYEPH LLFSSESTLH
960 970 980 990 1000
RYEVHPYGTL PVGPGPEFKT TLRVQNLGCY VVSGLIISAL LPAVAHGGNY
1010 1020 1030 1040 1050
FLSLSQVITN NASCIVQNLT EPPGPPVHPE ELQHTNRLNG SNTQCQVVRC
1060 1070 1080 1090 1100
HLGQLAKGTE VSVGLLRLVH NEFFRRAKFK SLTVVSTFEL GTEEGSVLQL
1110 1120 1130 1140 1150
TEASRWSESL LEVVQTRPIL ISLWILIGSV LGGLLLLALL VFCLWKLGFF
1160
AHKKIPEEEK REEKLEQ
Length:1,167
Mass (Da):127,602
Last modified:October 3, 2006 - v2
Checksum:i2F7FF938B4C0CBAC
GO
Isoform 2 (identifier: O75578-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     123-124: AC → VS
     125-1167: Missing.

Note: No experimental confirmation available.
Show »
Length:124
Mass (Da):13,352
Checksum:i562249D8A5B80416
GO
Isoform 3 (identifier: O75578-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     19-161: Missing.

Note: No experimental confirmation available.
Show »
Length:1,024
Mass (Da):112,544
Checksum:i4A10A1E07452B588
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti844L → I in AAC31952 (PubMed:9685391).Curated1
Sequence conflicti909V → G in AAC31952 (PubMed:9685391).Curated1
Sequence conflicti926D → E in AAC31952 (PubMed:9685391).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_027768381R → Q.Corresponds to variant rs6665210dbSNPEnsembl.1
Natural variantiVAR_034026668R → W.Corresponds to variant rs36073645dbSNPEnsembl.1
Natural variantiVAR_027769691R → H.Corresponds to variant rs2274618dbSNPEnsembl.1
Natural variantiVAR_034027702A → T.Corresponds to variant rs35515885dbSNPEnsembl.1
Natural variantiVAR_027770725R → Q.Corresponds to variant rs2274616dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05448319 – 161Missing in isoform 3. 1 PublicationAdd BLAST143
Alternative sequenceiVSP_013114123 – 124AC → VS in isoform 2. 1 Publication2
Alternative sequenceiVSP_013115125 – 1167Missing in isoform 2. 1 PublicationAdd BLAST1043

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF074015 mRNA. Translation: AAC31952.1.
AF112345 mRNA. Translation: AAF21944.1.
AF172723 Genomic DNA. Translation: AAF61638.1.
AY358325 mRNA. Translation: AAQ88691.1.
AK314255 mRNA. Translation: BAG36921.1.
AL160282 Genomic DNA. No translation available.
CH471244 Genomic DNA. Translation: EAW71425.1.
BC140831 mRNA. Translation: AAI40832.1.
BC144637 mRNA. Translation: AAI44638.1.
CCDSiCCDS72869.1. [O75578-1]
CCDS76204.1. [O75578-3]
RefSeqiNP_001289969.1. NM_001303040.1.
NP_001289970.1. NM_001303041.1. [O75578-3]
NP_003628.2. NM_003637.4. [O75578-1]
UniGeneiHs.158237.

Genome annotation databases

EnsembliENST00000369304; ENSP00000358310; ENSG00000143127. [O75578-1]
ENST00000539363; ENSP00000439894; ENSG00000143127. [O75578-3]
GeneIDi8515.
KEGGihsa:8515.
UCSCiuc001eoa.4. human. [O75578-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF074015 mRNA. Translation: AAC31952.1.
AF112345 mRNA. Translation: AAF21944.1.
AF172723 Genomic DNA. Translation: AAF61638.1.
AY358325 mRNA. Translation: AAQ88691.1.
AK314255 mRNA. Translation: BAG36921.1.
AL160282 Genomic DNA. No translation available.
CH471244 Genomic DNA. Translation: EAW71425.1.
BC140831 mRNA. Translation: AAI40832.1.
BC144637 mRNA. Translation: AAI44638.1.
CCDSiCCDS72869.1. [O75578-1]
CCDS76204.1. [O75578-3]
RefSeqiNP_001289969.1. NM_001303040.1.
NP_001289970.1. NM_001303041.1. [O75578-3]
NP_003628.2. NM_003637.4. [O75578-1]
UniGeneiHs.158237.

3D structure databases

ProteinModelPortaliO75578.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114087. 1 interactor.
IntActiO75578. 1 interactor.
STRINGi9606.ENSP00000358310.

Chemistry databases

ChEMBLiCHEMBL5882.

PTM databases

iPTMnetiO75578.
PhosphoSitePlusiO75578.

Polymorphism and mutation databases

BioMutaiITGA10.

Proteomic databases

PaxDbiO75578.
PeptideAtlasiO75578.
PRIDEiO75578.

Protocols and materials databases

DNASUi8515.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369304; ENSP00000358310; ENSG00000143127. [O75578-1]
ENST00000539363; ENSP00000439894; ENSG00000143127. [O75578-3]
GeneIDi8515.
KEGGihsa:8515.
UCSCiuc001eoa.4. human. [O75578-1]

Organism-specific databases

CTDi8515.
DisGeNETi8515.
GeneCardsiITGA10.
HGNCiHGNC:6135. ITGA10.
MIMi604042. gene.
neXtProtiNX_O75578.
OpenTargetsiENSG00000143127.
PharmGKBiPA29936.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3637. Eukaryota.
ENOG410XPVZ. LUCA.
GeneTreeiENSGT00760000118782.
HOGENOMiHOG000059610.
HOVERGENiHBG006185.
InParanoidiO75578.
KOiK06586.
OMAiGPQNKET.
OrthoDBiEOG091G00QA.
PhylomeDBiO75578.
TreeFamiTF105391.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000143127-MONOMER.
ReactomeiR-HSA-216083. Integrin cell surface interactions.
R-HSA-447041. CHL1 interactions.
R-HSA-75892. Platelet Adhesion to exposed collagen.
SIGNORiO75578.

Miscellaneous databases

ChiTaRSiITGA10. human.
GeneWikiiITGA10.
GenomeRNAii8515.
PROiO75578.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000143127.
CleanExiHS_ITGA10.
GenevisibleiO75578. HS.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR032695. Integrin_dom.
IPR002035. VWF_A.
[Graphical view]
PfamiPF01839. FG-GAP. 2 hits.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 3 hits.
PROSITEiPS51470. FG_GAP. 7 hits.
PS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiITA10_HUMAN
AccessioniPrimary (citable) accession number: O75578
Secondary accession number(s): B2RAM4
, B2RTV5, Q6UXJ6, Q9UHZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: October 3, 2006
Last modified: November 2, 2016
This is version 154 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.