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Protein

Integrin alpha-10

Gene

ITGA10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Integrin alpha-10/beta-1 is a receptor for collagen.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi494 – 5029Sequence analysis
Calcium bindingi558 – 5669Sequence analysis
Calcium bindingi620 – 6289Sequence analysis

GO - Molecular functioni

  • collagen binding Source: ProtInc
  • collagen binding involved in cell-matrix adhesion Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • cell-matrix adhesion Source: UniProtKB
  • extracellular matrix organization Source: Reactome
  • integrin-mediated signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Integrin, Receptor

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-216083. Integrin cell surface interactions.
R-HSA-447041. CHL1 interactions.
R-HSA-75892. Platelet Adhesion to exposed collagen.
SIGNORiO75578.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin alpha-10
Gene namesi
Name:ITGA10
ORF Names:UNQ468/PRO827
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:6135. ITGA10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 11221100ExtracellularSequence analysisAdd
BLAST
Transmembranei1123 – 114523HelicalSequence analysisAdd
BLAST
Topological domaini1146 – 116722CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integrin alpha10-beta1 complex Source: UniProtKB
  • integrin complex Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29936.

Chemistry

ChEMBLiCHEMBL5882.

Polymorphism and mutation databases

BioMutaiITGA10.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 11671145Integrin alpha-10PRO_0000016317Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi76 ↔ 86By similarity
Glycosylationi98 – 981N-linked (GlcNAc...)Sequence analysis
Glycosylationi234 – 2341N-linked (GlcNAc...)Sequence analysis
Glycosylationi336 – 3361N-linked (GlcNAc...)Sequence analysis
Glycosylationi364 – 3641N-linked (GlcNAc...)Sequence analysis
Disulfide bondi666 ↔ 675By similarity
Disulfide bondi681 ↔ 736By similarity
Glycosylationi733 – 7331N-linked (GlcNAc...)Sequence analysis
Glycosylationi763 – 7631N-linked (GlcNAc...)Sequence analysis
Disulfide bondi789 ↔ 795By similarity
Glycosylationi839 – 8391N-linked (GlcNAc...)Sequence analysis
Glycosylationi921 – 9211N-linked (GlcNAc...)Sequence analysis
Glycosylationi1011 – 10111N-linked (GlcNAc...)Sequence analysis
Glycosylationi1018 – 10181N-linked (GlcNAc...)Sequence analysis
Glycosylationi1039 – 10391N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO75578.
PeptideAtlasiO75578.
PRIDEiO75578.

PTM databases

iPTMnetiO75578.
PhosphoSiteiO75578.

Expressioni

Tissue specificityi

Widely expressed with highest expression in muscle and heart. Found in articular cartilage.

Gene expression databases

BgeeiENSG00000143127.
CleanExiHS_ITGA10.
GenevisibleiO75578. HS.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. Alpha-10 associates with beta-1.

GO - Molecular functioni

  • collagen binding Source: ProtInc
  • collagen binding involved in cell-matrix adhesion Source: UniProtKB

Protein-protein interaction databases

BioGridi114087. 1 interaction.
IntActiO75578. 1 interaction.
STRINGi9606.ENSP00000358310.

Structurei

3D structure databases

ProteinModelPortaliO75578.
SMRiO75578. Positions 23-962.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati24 – 8562FG-GAP 1PROSITE-ProRule annotationAdd
BLAST
Repeati95 – 15460FG-GAP 2PROSITE-ProRule annotationAdd
BLAST
Domaini167 – 350184VWFAPROSITE-ProRule annotationAdd
BLAST
Repeati361 – 41252FG-GAP 3PROSITE-ProRule annotationAdd
BLAST
Repeati417 – 47054FG-GAP 4PROSITE-ProRule annotationAdd
BLAST
Repeati472 – 53463FG-GAP 5PROSITE-ProRule annotationAdd
BLAST
Repeati535 – 59359FG-GAP 6PROSITE-ProRule annotationAdd
BLAST
Repeati597 – 65761FG-GAP 7PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1134 – 11407Poly-Leu

Domaini

The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated
Contains 7 FG-GAP repeats.PROSITE-ProRule annotation
Contains 1 VWFA domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3637. Eukaryota.
ENOG410XPVZ. LUCA.
GeneTreeiENSGT00760000118782.
HOGENOMiHOG000059610.
HOVERGENiHBG006185.
InParanoidiO75578.
KOiK06586.
OMAiGPQNKET.
OrthoDBiEOG091G00QA.
PhylomeDBiO75578.
TreeFamiTF105391.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR032695. Integrin_dom.
IPR002035. VWF_A.
[Graphical view]
PfamiPF01839. FG-GAP. 2 hits.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 3 hits.
PROSITEiPS51470. FG_GAP. 7 hits.
PS50234. VWFA. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75578-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELPFVTHLF LPLVFLTGLC SPFNLDEHHP RLFPGPPEAE FGYSVLQHVG
60 70 80 90 100
GGQRWMLVGA PWDGPSGDRR GDVYRCPVGG AHNAPCAKGH LGDYQLGNSS
110 120 130 140 150
HPAVNMHLGM SLLETDGDGG FMACAPLWSR ACGSSVFSSG ICARVDASFQ
160 170 180 190 200
PQGSLAPTAQ RCPTYMDVVI VLDGSNSIYP WSEVQTFLRR LVGKLFIDPE
210 220 230 240 250
QIQVGLVQYG ESPVHEWSLG DFRTKEEVVR AAKNLSRREG RETKTAQAIM
260 270 280 290 300
VACTEGFSQS HGGRPEAARL LVVVTDGESH DGEELPAALK ACEAGRVTRY
310 320 330 340 350
GIAVLGHYLR RQRDPSSFLR EIRTIASDPD ERFFFNVTDE AALTDIVDAL
360 370 380 390 400
GDRIFGLEGS HAENESSFGL EMSQIGFSTH RLKDGILFGM VGAYDWGGSV
410 420 430 440 450
LWLEGGHRLF PPRMALEDEF PPALQNHAAY LGYSVSSMLL RGGRRLFLSG
460 470 480 490 500
APRFRHRGKV IAFQLKKDGA VRVAQSLQGE QIGSYFGSEL CPLDTDRDGT
510 520 530 540 550
TDVLLVAAPM FLGPQNKETG RVYVYLVGQQ SLLTLQGTLQ PEPPQDARFG
560 570 580 590 600
FAMGALPDLN QDGFADVAVG APLEDGHQGA LYLYHGTQSG VRPHPAQRIA
610 620 630 640 650
AASMPHALSY FGRSVDGRLD LDGDDLVDVA VGAQGAAILL SSRPIVHLTP
660 670 680 690 700
SLEVTPQAIS VVQRDCRRRG QEAVCLTAAL CFQVTSRTPG RWDHQFYMRF
710 720 730 740 750
TASLDEWTAG ARAAFDGSGQ RLSPRRLRLS VGNVTCEQLH FHVLDTSDYL
760 770 780 790 800
RPVALTVTFA LDNTTKPGPV LNEGSPTSIQ KLVPFSKDCG PDNECVTDLV
810 820 830 840 850
LQVNMDIRGS RKAPFVVRGG RRKVLVSTTL ENRKENAYNT SLSLIFSRNL
860 870 880 890 900
HLASLTPQRE SPIKVECAAP SAHARLCSVG HPVFQTGAKV TFLLEFEFSC
910 920 930 940 950
SSLLSQVFVK LTASSDSLER NGTLQDNTAQ TSAYIQYEPH LLFSSESTLH
960 970 980 990 1000
RYEVHPYGTL PVGPGPEFKT TLRVQNLGCY VVSGLIISAL LPAVAHGGNY
1010 1020 1030 1040 1050
FLSLSQVITN NASCIVQNLT EPPGPPVHPE ELQHTNRLNG SNTQCQVVRC
1060 1070 1080 1090 1100
HLGQLAKGTE VSVGLLRLVH NEFFRRAKFK SLTVVSTFEL GTEEGSVLQL
1110 1120 1130 1140 1150
TEASRWSESL LEVVQTRPIL ISLWILIGSV LGGLLLLALL VFCLWKLGFF
1160
AHKKIPEEEK REEKLEQ
Length:1,167
Mass (Da):127,602
Last modified:October 3, 2006 - v2
Checksum:i2F7FF938B4C0CBAC
GO
Isoform 2 (identifier: O75578-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     123-124: AC → VS
     125-1167: Missing.

Note: No experimental confirmation available.
Show »
Length:124
Mass (Da):13,352
Checksum:i562249D8A5B80416
GO
Isoform 3 (identifier: O75578-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     19-161: Missing.

Note: No experimental confirmation available.
Show »
Length:1,024
Mass (Da):112,544
Checksum:i4A10A1E07452B588
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti844 – 8441L → I in AAC31952 (PubMed:9685391).Curated
Sequence conflicti909 – 9091V → G in AAC31952 (PubMed:9685391).Curated
Sequence conflicti926 – 9261D → E in AAC31952 (PubMed:9685391).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti381 – 3811R → Q.
Corresponds to variant rs6665210 [ dbSNP | Ensembl ].
VAR_027768
Natural varianti668 – 6681R → W.
Corresponds to variant rs36073645 [ dbSNP | Ensembl ].
VAR_034026
Natural varianti691 – 6911R → H.
Corresponds to variant rs2274618 [ dbSNP | Ensembl ].
VAR_027769
Natural varianti702 – 7021A → T.
Corresponds to variant rs35515885 [ dbSNP | Ensembl ].
VAR_034027
Natural varianti725 – 7251R → Q.
Corresponds to variant rs2274616 [ dbSNP | Ensembl ].
VAR_027770

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei19 – 161143Missing in isoform 3. 1 PublicationVSP_054483Add
BLAST
Alternative sequencei123 – 1242AC → VS in isoform 2. 1 PublicationVSP_013114
Alternative sequencei125 – 11671043Missing in isoform 2. 1 PublicationVSP_013115Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF074015 mRNA. Translation: AAC31952.1.
AF112345 mRNA. Translation: AAF21944.1.
AF172723 Genomic DNA. Translation: AAF61638.1.
AY358325 mRNA. Translation: AAQ88691.1.
AK314255 mRNA. Translation: BAG36921.1.
AL160282 Genomic DNA. No translation available.
CH471244 Genomic DNA. Translation: EAW71425.1.
BC140831 mRNA. Translation: AAI40832.1.
BC144637 mRNA. Translation: AAI44638.1.
CCDSiCCDS72869.1. [O75578-1]
CCDS76204.1. [O75578-3]
RefSeqiNP_001289969.1. NM_001303040.1.
NP_001289970.1. NM_001303041.1. [O75578-3]
NP_003628.2. NM_003637.4. [O75578-1]
UniGeneiHs.158237.

Genome annotation databases

EnsembliENST00000369304; ENSP00000358310; ENSG00000143127. [O75578-1]
ENST00000539363; ENSP00000439894; ENSG00000143127. [O75578-3]
GeneIDi8515.
KEGGihsa:8515.
UCSCiuc001eoa.4. human. [O75578-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF074015 mRNA. Translation: AAC31952.1.
AF112345 mRNA. Translation: AAF21944.1.
AF172723 Genomic DNA. Translation: AAF61638.1.
AY358325 mRNA. Translation: AAQ88691.1.
AK314255 mRNA. Translation: BAG36921.1.
AL160282 Genomic DNA. No translation available.
CH471244 Genomic DNA. Translation: EAW71425.1.
BC140831 mRNA. Translation: AAI40832.1.
BC144637 mRNA. Translation: AAI44638.1.
CCDSiCCDS72869.1. [O75578-1]
CCDS76204.1. [O75578-3]
RefSeqiNP_001289969.1. NM_001303040.1.
NP_001289970.1. NM_001303041.1. [O75578-3]
NP_003628.2. NM_003637.4. [O75578-1]
UniGeneiHs.158237.

3D structure databases

ProteinModelPortaliO75578.
SMRiO75578. Positions 23-962.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114087. 1 interaction.
IntActiO75578. 1 interaction.
STRINGi9606.ENSP00000358310.

Chemistry

ChEMBLiCHEMBL5882.

PTM databases

iPTMnetiO75578.
PhosphoSiteiO75578.

Polymorphism and mutation databases

BioMutaiITGA10.

Proteomic databases

PaxDbiO75578.
PeptideAtlasiO75578.
PRIDEiO75578.

Protocols and materials databases

DNASUi8515.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369304; ENSP00000358310; ENSG00000143127. [O75578-1]
ENST00000539363; ENSP00000439894; ENSG00000143127. [O75578-3]
GeneIDi8515.
KEGGihsa:8515.
UCSCiuc001eoa.4. human. [O75578-1]

Organism-specific databases

CTDi8515.
GeneCardsiITGA10.
HGNCiHGNC:6135. ITGA10.
MIMi604042. gene.
neXtProtiNX_O75578.
PharmGKBiPA29936.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3637. Eukaryota.
ENOG410XPVZ. LUCA.
GeneTreeiENSGT00760000118782.
HOGENOMiHOG000059610.
HOVERGENiHBG006185.
InParanoidiO75578.
KOiK06586.
OMAiGPQNKET.
OrthoDBiEOG091G00QA.
PhylomeDBiO75578.
TreeFamiTF105391.

Enzyme and pathway databases

ReactomeiR-HSA-216083. Integrin cell surface interactions.
R-HSA-447041. CHL1 interactions.
R-HSA-75892. Platelet Adhesion to exposed collagen.
SIGNORiO75578.

Miscellaneous databases

ChiTaRSiITGA10. human.
GeneWikiiITGA10.
GenomeRNAii8515.
PROiO75578.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000143127.
CleanExiHS_ITGA10.
GenevisibleiO75578. HS.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR032695. Integrin_dom.
IPR002035. VWF_A.
[Graphical view]
PfamiPF01839. FG-GAP. 2 hits.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 3 hits.
PROSITEiPS51470. FG_GAP. 7 hits.
PS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiITA10_HUMAN
AccessioniPrimary (citable) accession number: O75578
Secondary accession number(s): B2RAM4
, B2RTV5, Q6UXJ6, Q9UHZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: October 3, 2006
Last modified: September 7, 2016
This is version 152 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.