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Protein

Peptide chain release factor 1, mitochondrial

Gene

MTRF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain non-cognate termination stop codons AGG and AGA.

Caution

GO - Molecular functioni

  • translation release factor activity Source: ProtInc

GO - Biological processi

  • regulation of translational termination Source: ProtInc

Keywordsi

Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide chain release factor 1, mitochondrial
Short name:
MRF-1
Short name:
MtRF-1
Gene namesi
Name:MTRF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000120662.15
HGNCiHGNC:7469 MTRF1
MIMi604601 gene
neXtProtiNX_O75570

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi9617
OpenTargetsiENSG00000120662
PharmGKBiPA31273

Polymorphism and mutation databases

BioMutaiMTRF1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000030333? – 445Peptide chain release factor 1, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei313N5-methylglutamineBy similarity1

Post-translational modificationi

Methylation of glutamine in the GGQ triplet is conserved from bacteria to mammals.By similarity

Keywords - PTMi

Methylation

Proteomic databases

EPDiO75570
MaxQBiO75570
PaxDbiO75570
PeptideAtlasiO75570
PRIDEiO75570

PTM databases

iPTMnetiO75570
PhosphoSitePlusiO75570
SwissPalmiO75570

Expressioni

Gene expression databases

BgeeiENSG00000120662
CleanExiHS_MTRF1
ExpressionAtlasiO75570 baseline and differential
GenevisibleiO75570 HS

Organism-specific databases

HPAiHPA043316

Interactioni

Protein-protein interaction databases

BioGridi11497822 interactors.
IntActiO75570 2 interactors.
STRINGi9606.ENSP00000368790

Structurei

3D structure databases

ProteinModelPortaliO75570
SMRiO75570
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2726 Eukaryota
COG0216 LUCA
GeneTreeiENSGT00390000011879
HOGENOMiHOG000074815
HOVERGENiHBG017071
InParanoidiO75570
KOiK02835
OMAiFLCGEKC
OrthoDBiEOG091G0O7T
PhylomeDBiO75570
TreeFamiTF313720

Family and domain databases

InterProiView protein in InterPro
IPR005139 PCRF
IPR000352 Pep_chain_release_fac_I_II
PfamiView protein in Pfam
PF03462 PCRF, 1 hit
PF00472 RF-1, 1 hit
SMARTiView protein in SMART
SM00937 PCRF, 1 hit
PROSITEiView protein in PROSITE
PS00745 RF_PROK_I, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75570-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNRHLCVWLF RHPSLNGYLQ CHIQLHSHQF RQIHLDTRLQ VFRQNRNCIL
60 70 80 90 100
HLLSKNWSRR YCHQDTKMLW KHKALQKYME NLSKEYQTLE QCLQHIPVNE
110 120 130 140 150
ENRRSLNRRH AELAPLAAIY QEIQETEQAI EELESMCKSL NKQDEKQLQE
160 170 180 190 200
LALEERQTID QKINMLYNEL FQSLVPKEKY DKNDVILEVT AGRTTGGDIC
210 220 230 240 250
QQFTREIFDM YQNYSCYKHW QFELLNYTPA DYGGLHHAAA RISGDGVYKH
260 270 280 290 300
LKYEGGIHRV QRIPEVGLSS RMQRIHTGTM SVIVLPQPDE VDVKLDPKDL
310 320 330 340 350
RIDTFRAKGA GGQHVNKTDS AVRLVHIPTG LVVECQQERS QIKNKEIAFR
360 370 380 390 400
VLRARLYQQI IEKDKRQQQS ARKLQVGTRA QSERIRTYNF TQDRVSDHRI
410 420 430 440
AYEVRDIKEF LCGGKGLDQL IQRLLQSADE EAIAELLDEH LKSAK
Length:445
Mass (Da):52,306
Last modified:April 12, 2005 - v2
Checksum:i3DC637D90F04C6F7
GO
Isoform 2 (identifier: O75570-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGNGEVVLFSDAEM
     409-445: EFLCGGKGLD...LLDEHLKSAK → AQSHSTGGSR...FYVVGRAWIS

Note: No experimental confirmation available.
Show »
Length:468
Mass (Da):54,622
Checksum:iC344E292BE468528
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti63H → L in AAD12759 (PubMed:9838146).Curated1
Sequence conflicti71K → N in AAD12759 (PubMed:9838146).Curated1
Sequence conflicti102N → S in AAD12759 (PubMed:9838146).Curated1
Sequence conflicti123I → T in AAD12759 (PubMed:9838146).Curated1
Sequence conflicti134E → G in AAD12759 (PubMed:9838146).Curated1
Sequence conflicti143Q → R in AAD12759 (PubMed:9838146).Curated1
Sequence conflicti149Q → L in AAD12759 (PubMed:9838146).Curated1
Sequence conflicti224L → P in AAD12759 (PubMed:9838146).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0246032N → S. Corresponds to variant dbSNP:rs9532758Ensembl.1
Natural variantiVAR_034447324L → V. Corresponds to variant dbSNP:rs9566725Ensembl.1
Natural variantiVAR_051789407I → V. Corresponds to variant dbSNP:rs9315812Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0558581M → MGNGEVVLFSDAEM in isoform 2. 1 Publication1
Alternative sequenceiVSP_055859409 – 445EFLCG…LKSAK → AQSHSTGGSRDPAHSTFLSL DSVRSPGILIMTSSVRNFYV VGRAWIS in isoform 2. 1 PublicationAdd BLAST37

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF072934 mRNA Translation: AAD12759.1
AK294343 mRNA Translation: BAG57612.1
AL354696 Genomic DNA No translation available.
BC042196 mRNA Translation: AAH42196.1
CCDSiCCDS9378.1 [O75570-1]
RefSeqiNP_004285.2, NM_004294.2 [O75570-1]
XP_005266656.1, XM_005266599.2 [O75570-1]
XP_006719960.1, XM_006719897.2
XP_006719961.1, XM_006719898.2 [O75570-1]
XP_006719963.1, XM_006719900.2 [O75570-1]
XP_011533620.1, XM_011535318.2 [O75570-1]
XP_011533622.1, XM_011535320.2 [O75570-1]
XP_011533623.1, XM_011535321.2 [O75570-1]
XP_011533625.1, XM_011535323.2 [O75570-1]
XP_011533627.1, XM_011535325.2 [O75570-1]
XP_016876351.1, XM_017020862.1 [O75570-1]
XP_016876352.1, XM_017020863.1 [O75570-1]
XP_016876353.1, XM_017020864.1 [O75570-1]
XP_016876354.1, XM_017020865.1 [O75570-1]
XP_016876355.1, XM_017020866.1 [O75570-1]
XP_016876356.1, XM_017020867.1 [O75570-1]
XP_016876357.1, XM_017020868.1 [O75570-1]
XP_016876358.1, XM_017020869.1 [O75570-1]
XP_016876362.1, XM_017020873.1
XP_016876363.1, XM_017020874.1 [O75570-1]
XP_016876364.1, XM_017020875.1 [O75570-1]
UniGeneiHs.382176

Genome annotation databases

EnsembliENST00000379477; ENSP00000368790; ENSG00000120662 [O75570-1]
ENST00000379480; ENSP00000368793; ENSG00000120662 [O75570-1]
GeneIDi9617
KEGGihsa:9617
UCSCiuc001uxx.4 human [O75570-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRF1M_HUMAN
AccessioniPrimary (citable) accession number: O75570
Secondary accession number(s): B4DG01, Q5T6Y5, Q8IUQ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: April 12, 2005
Last modified: January 31, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome