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Protein

Peptide chain release factor 1, mitochondrial

Gene

MTRF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain non-cognate termination stop codons AGG and AGA.

GO - Molecular functioni

GO - Biological processi

  • mitochondrial translational termination Source: GO_Central
  • regulation of translational termination Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Protein biosynthesis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000120662-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide chain release factor 1, mitochondrial
Short name:
MRF-1
Short name:
MtRF-1
Gene namesi
Name:MTRF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:7469. MTRF1.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi9617.
OpenTargetsiENSG00000120662.
PharmGKBiPA31273.

Polymorphism and mutation databases

BioMutaiMTRF1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000030333? – 445Peptide chain release factor 1, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei313N5-methylglutamineBy similarity1

Post-translational modificationi

Methylation of glutamine in the GGQ triplet is conserved from bacteria to mammals.By similarity

Keywords - PTMi

Methylation

Proteomic databases

EPDiO75570.
MaxQBiO75570.
PaxDbiO75570.
PeptideAtlasiO75570.
PRIDEiO75570.

PTM databases

iPTMnetiO75570.
PhosphoSitePlusiO75570.
SwissPalmiO75570.

Expressioni

Gene expression databases

BgeeiENSG00000120662.
CleanExiHS_MTRF1.
ExpressionAtlasiO75570. baseline and differential.
GenevisibleiO75570. HS.

Organism-specific databases

HPAiHPA043316.

Interactioni

Protein-protein interaction databases

BioGridi114978. 2 interactors.
IntActiO75570. 2 interactors.
STRINGi9606.ENSP00000368790.

Structurei

3D structure databases

ProteinModelPortaliO75570.
SMRiO75570.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2726. Eukaryota.
COG0216. LUCA.
GeneTreeiENSGT00390000011879.
HOGENOMiHOG000074815.
HOVERGENiHBG017071.
InParanoidiO75570.
KOiK02835.
OMAiFLCGEKC.
OrthoDBiEOG091G0O7T.
PhylomeDBiO75570.
TreeFamiTF313720.

Family and domain databases

Gene3Di3.30.160.20. 1 hit.
InterProiIPR014720. dsRBD_dom.
IPR005139. PCRF.
IPR000352. Pep_chain_release_fac_I_II.
[Graphical view]
PfamiPF03462. PCRF. 1 hit.
PF00472. RF-1. 1 hit.
[Graphical view]
SMARTiSM00937. PCRF. 1 hit.
[Graphical view]
PROSITEiPS00745. RF_PROK_I. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75570-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNRHLCVWLF RHPSLNGYLQ CHIQLHSHQF RQIHLDTRLQ VFRQNRNCIL
60 70 80 90 100
HLLSKNWSRR YCHQDTKMLW KHKALQKYME NLSKEYQTLE QCLQHIPVNE
110 120 130 140 150
ENRRSLNRRH AELAPLAAIY QEIQETEQAI EELESMCKSL NKQDEKQLQE
160 170 180 190 200
LALEERQTID QKINMLYNEL FQSLVPKEKY DKNDVILEVT AGRTTGGDIC
210 220 230 240 250
QQFTREIFDM YQNYSCYKHW QFELLNYTPA DYGGLHHAAA RISGDGVYKH
260 270 280 290 300
LKYEGGIHRV QRIPEVGLSS RMQRIHTGTM SVIVLPQPDE VDVKLDPKDL
310 320 330 340 350
RIDTFRAKGA GGQHVNKTDS AVRLVHIPTG LVVECQQERS QIKNKEIAFR
360 370 380 390 400
VLRARLYQQI IEKDKRQQQS ARKLQVGTRA QSERIRTYNF TQDRVSDHRI
410 420 430 440
AYEVRDIKEF LCGGKGLDQL IQRLLQSADE EAIAELLDEH LKSAK
Length:445
Mass (Da):52,306
Last modified:April 12, 2005 - v2
Checksum:i3DC637D90F04C6F7
GO
Isoform 2 (identifier: O75570-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGNGEVVLFSDAEM
     409-445: EFLCGGKGLD...LLDEHLKSAK → AQSHSTGGSR...FYVVGRAWIS

Note: No experimental confirmation available.
Show »
Length:468
Mass (Da):54,622
Checksum:iC344E292BE468528
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti63H → L in AAD12759 (PubMed:9838146).Curated1
Sequence conflicti71K → N in AAD12759 (PubMed:9838146).Curated1
Sequence conflicti102N → S in AAD12759 (PubMed:9838146).Curated1
Sequence conflicti123I → T in AAD12759 (PubMed:9838146).Curated1
Sequence conflicti134E → G in AAD12759 (PubMed:9838146).Curated1
Sequence conflicti143Q → R in AAD12759 (PubMed:9838146).Curated1
Sequence conflicti149Q → L in AAD12759 (PubMed:9838146).Curated1
Sequence conflicti224L → P in AAD12759 (PubMed:9838146).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0246032N → S.Corresponds to variant rs9532758dbSNPEnsembl.1
Natural variantiVAR_034447324L → V.Corresponds to variant rs9566725dbSNPEnsembl.1
Natural variantiVAR_051789407I → V.Corresponds to variant rs9315812dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0558581M → MGNGEVVLFSDAEM in isoform 2. 1 Publication1
Alternative sequenceiVSP_055859409 – 445EFLCG…LKSAK → AQSHSTGGSRDPAHSTFLSL DSVRSPGILIMTSSVRNFYV VGRAWIS in isoform 2. 1 PublicationAdd BLAST37

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF072934 mRNA. Translation: AAD12759.1.
AK294343 mRNA. Translation: BAG57612.1.
AL354696 Genomic DNA. Translation: CAI16615.1.
AL354696 Genomic DNA. Translation: CAI16617.1.
BC042196 mRNA. Translation: AAH42196.1.
CCDSiCCDS9378.1. [O75570-1]
RefSeqiNP_004285.2. NM_004294.2. [O75570-1]
XP_005266656.1. XM_005266599.2. [O75570-1]
XP_006719960.1. XM_006719897.2. [O75570-1]
XP_006719961.1. XM_006719898.2. [O75570-1]
XP_006719963.1. XM_006719900.2. [O75570-1]
XP_011533620.1. XM_011535318.2. [O75570-1]
XP_011533622.1. XM_011535320.2. [O75570-1]
XP_011533623.1. XM_011535321.2. [O75570-1]
XP_011533625.1. XM_011535323.2. [O75570-1]
XP_011533627.1. XM_011535325.2. [O75570-1]
XP_016876351.1. XM_017020862.1. [O75570-1]
XP_016876352.1. XM_017020863.1. [O75570-1]
XP_016876353.1. XM_017020864.1. [O75570-1]
XP_016876354.1. XM_017020865.1. [O75570-1]
XP_016876355.1. XM_017020866.1. [O75570-1]
XP_016876356.1. XM_017020867.1. [O75570-1]
XP_016876357.1. XM_017020868.1. [O75570-1]
XP_016876358.1. XM_017020869.1. [O75570-1]
XP_016876362.1. XM_017020873.1. [O75570-1]
XP_016876363.1. XM_017020874.1. [O75570-1]
XP_016876364.1. XM_017020875.1. [O75570-1]
UniGeneiHs.382176.

Genome annotation databases

EnsembliENST00000379477; ENSP00000368790; ENSG00000120662. [O75570-1]
ENST00000379480; ENSP00000368793; ENSG00000120662. [O75570-1]
GeneIDi9617.
KEGGihsa:9617.
UCSCiuc001uxx.4. human. [O75570-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF072934 mRNA. Translation: AAD12759.1.
AK294343 mRNA. Translation: BAG57612.1.
AL354696 Genomic DNA. Translation: CAI16615.1.
AL354696 Genomic DNA. Translation: CAI16617.1.
BC042196 mRNA. Translation: AAH42196.1.
CCDSiCCDS9378.1. [O75570-1]
RefSeqiNP_004285.2. NM_004294.2. [O75570-1]
XP_005266656.1. XM_005266599.2. [O75570-1]
XP_006719960.1. XM_006719897.2. [O75570-1]
XP_006719961.1. XM_006719898.2. [O75570-1]
XP_006719963.1. XM_006719900.2. [O75570-1]
XP_011533620.1. XM_011535318.2. [O75570-1]
XP_011533622.1. XM_011535320.2. [O75570-1]
XP_011533623.1. XM_011535321.2. [O75570-1]
XP_011533625.1. XM_011535323.2. [O75570-1]
XP_011533627.1. XM_011535325.2. [O75570-1]
XP_016876351.1. XM_017020862.1. [O75570-1]
XP_016876352.1. XM_017020863.1. [O75570-1]
XP_016876353.1. XM_017020864.1. [O75570-1]
XP_016876354.1. XM_017020865.1. [O75570-1]
XP_016876355.1. XM_017020866.1. [O75570-1]
XP_016876356.1. XM_017020867.1. [O75570-1]
XP_016876357.1. XM_017020868.1. [O75570-1]
XP_016876358.1. XM_017020869.1. [O75570-1]
XP_016876362.1. XM_017020873.1. [O75570-1]
XP_016876363.1. XM_017020874.1. [O75570-1]
XP_016876364.1. XM_017020875.1. [O75570-1]
UniGeneiHs.382176.

3D structure databases

ProteinModelPortaliO75570.
SMRiO75570.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114978. 2 interactors.
IntActiO75570. 2 interactors.
STRINGi9606.ENSP00000368790.

PTM databases

iPTMnetiO75570.
PhosphoSitePlusiO75570.
SwissPalmiO75570.

Polymorphism and mutation databases

BioMutaiMTRF1.

Proteomic databases

EPDiO75570.
MaxQBiO75570.
PaxDbiO75570.
PeptideAtlasiO75570.
PRIDEiO75570.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379477; ENSP00000368790; ENSG00000120662. [O75570-1]
ENST00000379480; ENSP00000368793; ENSG00000120662. [O75570-1]
GeneIDi9617.
KEGGihsa:9617.
UCSCiuc001uxx.4. human. [O75570-1]

Organism-specific databases

CTDi9617.
DisGeNETi9617.
GeneCardsiMTRF1.
HGNCiHGNC:7469. MTRF1.
HPAiHPA043316.
MIMi604601. gene.
neXtProtiNX_O75570.
OpenTargetsiENSG00000120662.
PharmGKBiPA31273.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2726. Eukaryota.
COG0216. LUCA.
GeneTreeiENSGT00390000011879.
HOGENOMiHOG000074815.
HOVERGENiHBG017071.
InParanoidiO75570.
KOiK02835.
OMAiFLCGEKC.
OrthoDBiEOG091G0O7T.
PhylomeDBiO75570.
TreeFamiTF313720.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000120662-MONOMER.

Miscellaneous databases

GeneWikiiMTRF1.
GenomeRNAii9617.
PROiO75570.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000120662.
CleanExiHS_MTRF1.
ExpressionAtlasiO75570. baseline and differential.
GenevisibleiO75570. HS.

Family and domain databases

Gene3Di3.30.160.20. 1 hit.
InterProiIPR014720. dsRBD_dom.
IPR005139. PCRF.
IPR000352. Pep_chain_release_fac_I_II.
[Graphical view]
PfamiPF03462. PCRF. 1 hit.
PF00472. RF-1. 1 hit.
[Graphical view]
SMARTiSM00937. PCRF. 1 hit.
[Graphical view]
PROSITEiPS00745. RF_PROK_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRF1M_HUMAN
AccessioniPrimary (citable) accession number: O75570
Secondary accession number(s): B4DG01, Q5T6Y5, Q8IUQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: April 12, 2005
Last modified: November 2, 2016
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.