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O75564 (JERKY_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Jerky protein homolog
Gene names
Name:JRK
Synonyms:JH8
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length520 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May bind DNA By similarity.

Subcellular location

Nucleus Potential.

Tissue specificity

Expressed ubiquitously. Ref.1

Sequence similarities

Belongs to the tigger transposable element derived protein family.

Contains 1 DDE domain.

Contains 1 HTH CENPB-type DNA-binding domain.

Ontologies

Keywords
   Cellular componentNucleus
   LigandDNA-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein binding

Inferred from physical interaction PubMed 21399610. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

CTNNB1P352223EBI-8607681,EBI-491549
Lef1P277823EBI-8607681,EBI-984464From a different organism.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 520520Jerky protein homolog
PRO_0000126128

Regions

Domain29 – 10173HTH CENPB-type
Domain130 – 334205DDE

Experimental info

Sequence conflict4281R → G in AAC32353. Ref.1
Sequence conflict480 – 52041VRRRR…TAGDN → ETVGLEDVVVTSPEELAIPK CCLEASTET in AAC32353. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O75564 [UniParc].

Last modified January 17, 2003. Version 2.
Checksum: 66C0A2E31DD17C98

FASTA52057,402
        10         20         30         40         50         60 
MSTLYDIRAH KAQLLRFFAS SDSNKALEQR RTLHTPKLEH LDRVLYEWFL GKRSEGVPVS 

        70         80         90        100        110        120 
GPMLIEKAKD FYEQMQLTEP CVFSGGWLWR FKARHGIKKL DASSEKQSAD HQAAEQFCAF 

       130        140        150        160        170        180 
FRSLAAEHGL SAEQVYNADE TGLFWRCLPN PTPEGGAVPG PKQGKDRLTV LMCANATGSH 

       190        200        210        220        230        240 
RLKPLAIGKC SGPRAFKGIQ HLPVAYKAQG NAWVDKEIFS DWFHHIFVPS VREHFRTIGL 

       250        260        270        280        290        300 
PEDSKAVLLL DSSRAHPQEA ELVSSNVFTI FLPASVASLV QPMEQGIRRD FMRNFINPPV 

       310        320        330        340        350        360 
PLQGPHARYN MNDAIFSVAC AWNAVPSHVF RRAWRKLWPS VAFAEGSSSE EELEAECFPV 

       370        380        390        400        410        420 
KPHNKSFAHI LELVKEGSSC PGQLRQRQAA SWGVAGREAE GGRPPAATSP AEVVWSSEKT 

       430        440        450        460        470        480 
PKADQDGRGD PGEGEEVAWE QAAVAFDAVL RFAERQPCFS AQEVGQLRAL RAVFRSQQQV 

       490        500        510        520 
RRRRGALGAV VKVEALQEGP GGCGATAQSP LPCSSTAGDN 

« Hide

References

[1]"JH8, a gene highly homologous to the mouse jerky gene, maps to the region for childhood absence epilepsy on 8q24."
Morita R., Miyazaki E., Fong C.-Y.G., Chen X.-N., Korenberg J.R., Delgado-Escueta A.V., Yamakawa K.
Biochem. Biophys. Res. Commun. 248:307-314(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Fetal brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF072467 mRNA. Translation: AAC32352.1.
AF072468 mRNA. Translation: AAC32353.1.
UniGeneHs.535903.
Hs.683465.

3D structure databases

ProteinModelPortalO75564.
SMRO75564. Positions 2-96.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActO75564. 4 interactions.
MINTMINT-8176614.
STRING9606.ENSP00000406898.

Proteomic databases

MaxQBO75564.
PaxDbO75564.
PRIDEO75564.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

GeneCardsGC08M143735.
HGNCHGNC:6199. JRK.
MIM603210. gene.
neXtProtNX_O75564.
Orphanet64280. Childhood absence epilepsy.
307. Juvenile myoclonic epilepsy.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG308602.
HOVERGENHBG052163.
PhylomeDBO75564.

Gene expression databases

CleanExHS_JRK.
GenevestigatorO75564.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR004875. DDE_SF_endonuclease_CENPB-like.
IPR009057. Homeodomain-like.
IPR006600. HTH_CenpB_DNA-bd_dom.
[Graphical view]
PfamPF03184. DDE_1. 1 hit.
PF03221. HTH_Tnp_Tc5. 1 hit.
[Graphical view]
SMARTSM00674. CENPB. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS51253. HTH_CENPB. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROO75564.
SOURCESearch...

Entry information

Entry nameJERKY_HUMAN
AccessionPrimary (citable) accession number: O75564
Secondary accession number(s): O75565
Entry history
Integrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: January 17, 2003
Last modified: June 11, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM