O75564 (JERKY_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Jerky protein homolog

Gene names

Name:	JRK
Synonyms:	JH8

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	520 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May bind DNA By similarity.
Subcellular location	Nucleus Potential.
Tissue specificity	Expressed ubiquitously. Ref.1
Sequence similarities	Belongs to the tigger transposable element derived protein family. Contains 1 DDE domain. Contains 1 HTH CENPB-type DNA-binding domain.

Ontologies

Keywords
Cellular component	Nucleus
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 520	520	Jerky protein homolog		PRO_0000126128
Regions
	Domain	29 – 101	73	HTH CENPB-type
	Domain	130 – 334	205	DDE
Experimental info
	Sequence conflict	428	1	R → G in AAC32353. Ref.1
	Sequence conflict	480 – 520	41	VRRRR…TAGDN → ETVGLEDVVVTSPEELAIPK CCLEASTET in AAC32353. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	O75564 [UniParc]. Last modified January 17, 2003. Version 2. Checksum: 66C0A2E31DD17C98	FASTA	520	57,402
	10 20 30 40 50 60 MSTLYDIRAH KAQLLRFFAS SDSNKALEQR RTLHTPKLEH LDRVLYEWFL GKRSEGVPVS 70 80 90 100 110 120 GPMLIEKAKD FYEQMQLTEP CVFSGGWLWR FKARHGIKKL DASSEKQSAD HQAAEQFCAF 130 140 150 160 170 180 FRSLAAEHGL SAEQVYNADE TGLFWRCLPN PTPEGGAVPG PKQGKDRLTV LMCANATGSH 190 200 210 220 230 240 RLKPLAIGKC SGPRAFKGIQ HLPVAYKAQG NAWVDKEIFS DWFHHIFVPS VREHFRTIGL 250 260 270 280 290 300 PEDSKAVLLL DSSRAHPQEA ELVSSNVFTI FLPASVASLV QPMEQGIRRD FMRNFINPPV 310 320 330 340 350 360 PLQGPHARYN MNDAIFSVAC AWNAVPSHVF RRAWRKLWPS VAFAEGSSSE EELEAECFPV 370 380 390 400 410 420 KPHNKSFAHI LELVKEGSSC PGQLRQRQAA SWGVAGREAE GGRPPAATSP AEVVWSSEKT 430 440 450 460 470 480 PKADQDGRGD PGEGEEVAWE QAAVAFDAVL RFAERQPCFS AQEVGQLRAL RAVFRSQQQV 490 500 510 520 RRRRGALGAV VKVEALQEGP GGCGATAQSP LPCSSTAGDN

References

[1]	"JH8, a gene highly homologous to the mouse jerky gene, maps to the region for childhood absence epilepsy on 8q24." Morita R., Miyazaki E., Fong C.-Y.G., Chen X.-N., Korenberg J.R., Delgado-Escueta A.V., Yamakawa K. Biochem. Biophys. Res. Commun. 248:307-314(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Fetal brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF072467 mRNA. Translation: AAC32352.1. AF072468 mRNA. Translation: AAC32353.1.
IPI	IPI00816279.
UniGene	Hs.535903. Hs.683465.
3D structure databases
ProteinModelPortal	O75564.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-8176614.
STRING	9606.ENSP00000406898.
Proteomic databases
PaxDb	O75564.
PRIDE	O75564.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
GeneCards	GC08M143735.
HGNC	HGNC:6199. JRK.
MIM	603210. gene+phenotype.
neXtProt	NX_O75564.
Orphanet	64280. Childhood absence epilepsy. 307. Juvenile myoclonic epilepsy.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG308602.
HOVERGEN	HBG052163.
Gene expression databases
CleanEx	HS_JRK.
Genevestigator	O75564.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR004875. DDE_SF_endonuclease_CENPB-like. IPR009057. Homeodomain-like. IPR006600. HTH_CenpB_DNA-bd_dom. [Graphical view]
Pfam	PF03184. DDE_1. 1 hit. PF03221. HTH_Tnp_Tc5. 1 hit. [Graphical view]
SMART	SM00674. CENPB. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS51253. HTH_CENPB. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

JERKY_HUMAN

Accession

Primary (citable) accession number: O75564
Secondary accession number(s): O75565

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 17, 2003
Last sequence update:	January 17, 2003
Last modified:	May 29, 2013
This is version 88 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.