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Protein

Jerky protein homolog

Gene

JRK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May bind DNA.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi38 – 58H-T-H motifPROSITE-ProRule annotationAdd BLAST21
DNA bindingi110 – 142H-T-H motifPROSITE-ProRule annotationAdd BLAST33

GO - Molecular functioni

GO - Biological processi

  • positive regulation of canonical Wnt signaling pathway Source: FlyBase

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Jerky protein homologCurated
Gene namesi
Name:JRKImported
Synonyms:JH81 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componentsi: Chromosome 8, Unplaced

Organism-specific databases

EuPathDBiHostDB:ENSG00000234616.8.
HGNCiHGNC:6199. JRK.
MIMi603210. gene.
neXtProtiNX_O75564.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi8629.
MalaCardsiJRK.
OpenTargetsiENSG00000234616.
Orphaneti64280. Childhood absence epilepsy.
307. Juvenile myoclonic epilepsy.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001261281 – 556Jerky protein homologAdd BLAST556

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei414PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO75564.
MaxQBiO75564.
PeptideAtlasiO75564.
PRIDEiO75564.

PTM databases

iPTMnetiO75564.
PhosphoSitePlusiO75564.

Expressioni

Tissue specificityi

Expressed ubiquitously.1 Publication

Gene expression databases

BgeeiENSG00000234616.
CleanExiHS_JRK.
ExpressionAtlasiD3DWI5. baseline and differential.

Organism-specific databases

HPAiHPA052675.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

IntActiO75564. 4 interactors.
MINTiO75564.

Structurei

3D structure databases

ProteinModelPortaliO75564.
SMRiO75564.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 62HTH psq-typePROSITE-ProRule annotationAdd BLAST52
Domaini77 – 149HTH CENPB-typePROSITE-ProRule annotationAdd BLAST73
Domaini213 – 382DDE-1Sequence analysisAdd BLAST170

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00760000119149.
HOVERGENiHBG052163.
InParanoidiO75564.
OMAiALMQEYN.
OrthoDBiEOG091G05QK.
PhylomeDBiO75564.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR004875. DDE_SF_endonuclease_dom.
IPR009057. Homeobox-like_sf.
IPR006600. HTH_CenpB_DNA-bd_dom.
PfamiView protein in Pfam
PF03184. DDE_1. 1 hit.
PF03221. HTH_Tnp_Tc5. 1 hit.
SMARTiView protein in SMART
SM00674. CENPB. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS51253. HTH_CENPB. 1 hit.
PS50960. HTH_PSQ. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75564-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASKPAAGKS RGEKRKRVVL TLKEKIDICT RLEKGESRKA LMQEYNVGMS
60 70 80 90 100
TLYDIRAHKA QLLRFFASSD SNKALEQRRT LHTPKLEHLD RVLYEWFLGK
110 120 130 140 150
RSEGVPVSGP MLIEKAKDFY EQMQLTEPCV FSGGWLWRFK ARHGIKKLDA
160 170 180 190 200
SSEKQSADHQ AAEQFCAFFR SLAAEHGLSA EQVYNADETG LFWRCLPNPT
210 220 230 240 250
PEGGAVPGPK QGKDRLTVLM CANATGSHRL KPLAIGKCSG PRAFKGIQHL
260 270 280 290 300
PVAYKAQGNA WVDKEIFSDW FHHIFVPSVR EHFRTIGLPE DSKAVLLLDS
310 320 330 340 350
SRAHPQEAEL VSSNVFTIFL PASVASLVQP MEQGIRRDFM RNFINPPVPL
360 370 380 390 400
QGPHARYNMN DAIFSVACAW NAVPSHVFRR AWRKLWPSVA FAEGSSSEEE
410 420 430 440 450
LEAECFPVKP HNKSFAHILE LVKEGSSCPG QLRQRQAASW GVAGREAEGG
460 470 480 490 500
RPPAATSPAE VVWSSEKTPK ADQDGRGDPG EGEEVAWEQA AVAFDAVLRF
510 520 530 540 550
AERQPCFSAQ EVGQLRALRA VFRSQQQETV GLEDVVVTSP EELAIPKCCL

EASTET
Length:556
Mass (Da):61,815
Last modified:March 28, 2018 - v3
Checksum:iB6D0E018C016335A
GO
Isoform 2 (identifier: O75564-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     528-556: ETVGLEDVVVTSPEELAIPKCCLEASTET → VRRRRGALGAVVKVEALQEGPGGCGATAQSPLPCSSTAGDN

Show »
Length:568
Mass (Da):62,789
Checksum:i53006397C52106DD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti476R → G in AAC32353 (PubMed:9675132).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_059375528 – 556ETVGL…ASTET → VRRRRGALGAVVKVEALQEG PGGCGATAQSPLPCSSTAGD N in isoform 2. Add BLAST29

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC108002 Genomic DNA. No translation available.
KC877375 Genomic DNA. No translation available.
CH471162 Genomic DNA. Translation: EAW82315.1.
CH471162 Genomic DNA. Translation: EAW82316.1.
CH471162 Genomic DNA. Translation: EAW82317.1.
BC043351 mRNA. Translation: AAH43351.1.
AF072467 mRNA. Translation: AAC32352.1.
AF072468 mRNA. Translation: AAC32353.1.
RefSeqiNP_001070995.2. NM_001077527.2.
NP_001266281.1. NM_001279352.1.
NP_003715.3. NM_003724.3.
XP_006716740.1. XM_006716677.3.
XP_006716741.1. XM_006716678.3.
XP_011515656.1. XM_011517354.1.
UniGeneiHs.535903.
Hs.683465.

Genome annotation databases

GeneIDi8629.
KEGGihsa:8629.
UCSCiuc033cbh.2. human.
uc033cbj.1. human.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiJERKY_HUMAN
AccessioniPrimary (citable) accession number: O75564
Secondary accession number(s): D3DWI5, O75565, Q86XJ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: March 28, 2018
Last modified: March 28, 2018
This is version 119 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome