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O75564

- JERKY_HUMAN

UniProt

O75564 - JERKY_HUMAN

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Protein
Jerky protein homolog
Gene
JRK, JH8
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

May bind DNA By similarity.

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. protein binding Source: IntAct
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Jerky protein homolog
Gene namesi
Name:JRK
Synonyms:JH8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:6199. JRK.

Subcellular locationi

Nucleus Reviewed prediction

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

Orphaneti64280. Childhood absence epilepsy.
307. Juvenile myoclonic epilepsy.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 520520Jerky protein homolog
PRO_0000126128Add
BLAST

Proteomic databases

MaxQBiO75564.
PaxDbiO75564.
PRIDEiO75564.

Expressioni

Tissue specificityi

Expressed ubiquitously.1 Publication

Gene expression databases

CleanExiHS_JRK.
GenevestigatoriO75564.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CTNNB1P352223EBI-8607681,EBI-491549
Lef1P277823EBI-8607681,EBI-984464From a different organism.

Protein-protein interaction databases

IntActiO75564. 4 interactions.
MINTiMINT-8176614.
STRINGi9606.ENSP00000406898.

Structurei

3D structure databases

ProteinModelPortaliO75564.
SMRiO75564. Positions 2-96.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 10173HTH CENPB-type
Add
BLAST
Domaini130 – 334205DDE
Add
BLAST

Sequence similaritiesi

Contains 1 DDE domain.

Phylogenomic databases

eggNOGiNOG308602.
HOVERGENiHBG052163.
PhylomeDBiO75564.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR004875. DDE_SF_endonuclease_CENPB-like.
IPR009057. Homeodomain-like.
IPR006600. HTH_CenpB_DNA-bd_dom.
[Graphical view]
PfamiPF03184. DDE_1. 1 hit.
PF03221. HTH_Tnp_Tc5. 1 hit.
[Graphical view]
SMARTiSM00674. CENPB. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51253. HTH_CENPB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O75564-1 [UniParc]FASTAAdd to Basket

« Hide

MSTLYDIRAH KAQLLRFFAS SDSNKALEQR RTLHTPKLEH LDRVLYEWFL    50
GKRSEGVPVS GPMLIEKAKD FYEQMQLTEP CVFSGGWLWR FKARHGIKKL 100
DASSEKQSAD HQAAEQFCAF FRSLAAEHGL SAEQVYNADE TGLFWRCLPN 150
PTPEGGAVPG PKQGKDRLTV LMCANATGSH RLKPLAIGKC SGPRAFKGIQ 200
HLPVAYKAQG NAWVDKEIFS DWFHHIFVPS VREHFRTIGL PEDSKAVLLL 250
DSSRAHPQEA ELVSSNVFTI FLPASVASLV QPMEQGIRRD FMRNFINPPV 300
PLQGPHARYN MNDAIFSVAC AWNAVPSHVF RRAWRKLWPS VAFAEGSSSE 350
EELEAECFPV KPHNKSFAHI LELVKEGSSC PGQLRQRQAA SWGVAGREAE 400
GGRPPAATSP AEVVWSSEKT PKADQDGRGD PGEGEEVAWE QAAVAFDAVL 450
RFAERQPCFS AQEVGQLRAL RAVFRSQQQV RRRRGALGAV VKVEALQEGP 500
GGCGATAQSP LPCSSTAGDN 520
Length:520
Mass (Da):57,402
Last modified:January 17, 2003 - v2
Checksum:i66C0A2E31DD17C98
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti428 – 4281R → G in AAC32353. 1 Publication
Sequence conflicti480 – 52041VRRRR…TAGDN → ETVGLEDVVVTSPEELAIPK CCLEASTET in AAC32353. 1 Publication
Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF072467 mRNA. Translation: AAC32352.1.
AF072468 mRNA. Translation: AAC32353.1.
UniGeneiHs.535903.
Hs.683465.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF072467 mRNA. Translation: AAC32352.1 .
AF072468 mRNA. Translation: AAC32353.1 .
UniGenei Hs.535903.
Hs.683465.

3D structure databases

ProteinModelPortali O75564.
SMRi O75564. Positions 2-96.
ModBasei Search...

Protein-protein interaction databases

IntActi O75564. 4 interactions.
MINTi MINT-8176614.
STRINGi 9606.ENSP00000406898.

Proteomic databases

MaxQBi O75564.
PaxDbi O75564.
PRIDEi O75564.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

GeneCardsi GC08M143735.
HGNCi HGNC:6199. JRK.
MIMi 603210. gene.
neXtProti NX_O75564.
Orphaneti 64280. Childhood absence epilepsy.
307. Juvenile myoclonic epilepsy.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG308602.
HOVERGENi HBG052163.
PhylomeDBi O75564.

Miscellaneous databases

PROi O75564.
SOURCEi Search...

Gene expression databases

CleanExi HS_JRK.
Genevestigatori O75564.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR004875. DDE_SF_endonuclease_CENPB-like.
IPR009057. Homeodomain-like.
IPR006600. HTH_CenpB_DNA-bd_dom.
[Graphical view ]
Pfami PF03184. DDE_1. 1 hit.
PF03221. HTH_Tnp_Tc5. 1 hit.
[Graphical view ]
SMARTi SM00674. CENPB. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS51253. HTH_CENPB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "JH8, a gene highly homologous to the mouse jerky gene, maps to the region for childhood absence epilepsy on 8q24."
    Morita R., Miyazaki E., Fong C.-Y.G., Chen X.-N., Korenberg J.R., Delgado-Escueta A.V., Yamakawa K.
    Biochem. Biophys. Res. Commun. 248:307-314(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Fetal brain.

Entry informationi

Entry nameiJERKY_HUMAN
AccessioniPrimary (citable) accession number: O75564
Secondary accession number(s): O75565
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: January 17, 2003
Last modified: June 11, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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