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O75564

- JERKY_HUMAN

UniProt

O75564 - JERKY_HUMAN

Protein

Jerky protein homolog

Gene

JRK

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 2 (17 Jan 2003)
      Previous versions | rss
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    Functioni

    May bind DNA.By similarity

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. protein binding Source: IntAct

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Jerky protein homolog
    Gene namesi
    Name:JRK
    Synonyms:JH8
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:6199. JRK.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    Orphaneti64280. Childhood absence epilepsy.
    307. Juvenile myoclonic epilepsy.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 520520Jerky protein homologPRO_0000126128Add
    BLAST

    Proteomic databases

    MaxQBiO75564.
    PaxDbiO75564.
    PRIDEiO75564.

    Expressioni

    Tissue specificityi

    Expressed ubiquitously.1 Publication

    Gene expression databases

    CleanExiHS_JRK.
    GenevestigatoriO75564.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CTNNB1P352223EBI-8607681,EBI-491549
    Lef1P277823EBI-8607681,EBI-984464From a different organism.

    Protein-protein interaction databases

    IntActiO75564. 4 interactions.
    MINTiMINT-8176614.
    STRINGi9606.ENSP00000406898.

    Structurei

    3D structure databases

    ProteinModelPortaliO75564.
    SMRiO75564. Positions 2-96.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini29 – 10173HTH CENPB-typePROSITE-ProRule annotationAdd
    BLAST
    Domaini130 – 334205DDEAdd
    BLAST

    Sequence similaritiesi

    Contains 1 DDE domain.Curated
    Contains 1 HTH CENPB-type DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG308602.
    HOVERGENiHBG052163.
    PhylomeDBiO75564.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR004875. DDE_SF_endonuclease_CENPB-like.
    IPR009057. Homeodomain-like.
    IPR006600. HTH_CenpB_DNA-bd_dom.
    [Graphical view]
    PfamiPF03184. DDE_1. 1 hit.
    PF03221. HTH_Tnp_Tc5. 1 hit.
    [Graphical view]
    SMARTiSM00674. CENPB. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS51253. HTH_CENPB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O75564-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTLYDIRAH KAQLLRFFAS SDSNKALEQR RTLHTPKLEH LDRVLYEWFL    50
    GKRSEGVPVS GPMLIEKAKD FYEQMQLTEP CVFSGGWLWR FKARHGIKKL 100
    DASSEKQSAD HQAAEQFCAF FRSLAAEHGL SAEQVYNADE TGLFWRCLPN 150
    PTPEGGAVPG PKQGKDRLTV LMCANATGSH RLKPLAIGKC SGPRAFKGIQ 200
    HLPVAYKAQG NAWVDKEIFS DWFHHIFVPS VREHFRTIGL PEDSKAVLLL 250
    DSSRAHPQEA ELVSSNVFTI FLPASVASLV QPMEQGIRRD FMRNFINPPV 300
    PLQGPHARYN MNDAIFSVAC AWNAVPSHVF RRAWRKLWPS VAFAEGSSSE 350
    EELEAECFPV KPHNKSFAHI LELVKEGSSC PGQLRQRQAA SWGVAGREAE 400
    GGRPPAATSP AEVVWSSEKT PKADQDGRGD PGEGEEVAWE QAAVAFDAVL 450
    RFAERQPCFS AQEVGQLRAL RAVFRSQQQV RRRRGALGAV VKVEALQEGP 500
    GGCGATAQSP LPCSSTAGDN 520
    Length:520
    Mass (Da):57,402
    Last modified:January 17, 2003 - v2
    Checksum:i66C0A2E31DD17C98
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti428 – 4281R → G in AAC32353. (PubMed:9675132)Curated
    Sequence conflicti480 – 52041VRRRR…TAGDN → ETVGLEDVVVTSPEELAIPK CCLEASTET in AAC32353. (PubMed:9675132)CuratedAdd
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF072467 mRNA. Translation: AAC32352.1.
    AF072468 mRNA. Translation: AAC32353.1.
    UniGeneiHs.535903.
    Hs.683465.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF072467 mRNA. Translation: AAC32352.1 .
    AF072468 mRNA. Translation: AAC32353.1 .
    UniGenei Hs.535903.
    Hs.683465.

    3D structure databases

    ProteinModelPortali O75564.
    SMRi O75564. Positions 2-96.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O75564. 4 interactions.
    MINTi MINT-8176614.
    STRINGi 9606.ENSP00000406898.

    Proteomic databases

    MaxQBi O75564.
    PaxDbi O75564.
    PRIDEi O75564.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    GeneCardsi GC08M143735.
    HGNCi HGNC:6199. JRK.
    MIMi 603210. gene.
    neXtProti NX_O75564.
    Orphaneti 64280. Childhood absence epilepsy.
    307. Juvenile myoclonic epilepsy.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG308602.
    HOVERGENi HBG052163.
    PhylomeDBi O75564.

    Miscellaneous databases

    PROi O75564.
    SOURCEi Search...

    Gene expression databases

    CleanExi HS_JRK.
    Genevestigatori O75564.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR004875. DDE_SF_endonuclease_CENPB-like.
    IPR009057. Homeodomain-like.
    IPR006600. HTH_CenpB_DNA-bd_dom.
    [Graphical view ]
    Pfami PF03184. DDE_1. 1 hit.
    PF03221. HTH_Tnp_Tc5. 1 hit.
    [Graphical view ]
    SMARTi SM00674. CENPB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS51253. HTH_CENPB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "JH8, a gene highly homologous to the mouse jerky gene, maps to the region for childhood absence epilepsy on 8q24."
      Morita R., Miyazaki E., Fong C.-Y.G., Chen X.-N., Korenberg J.R., Delgado-Escueta A.V., Yamakawa K.
      Biochem. Biophys. Res. Commun. 248:307-314(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Fetal brain.

    Entry informationi

    Entry nameiJERKY_HUMAN
    AccessioniPrimary (citable) accession number: O75564
    Secondary accession number(s): O75565
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 17, 2003
    Last sequence update: January 17, 2003
    Last modified: October 1, 2014
    This is version 96 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3