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Protein

Jerky protein homolog

Gene

JRK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May bind DNA.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:G66-31142-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Jerky protein homolog
Gene namesi
Name:JRK
Synonyms:JH8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:6199. JRK.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi8629.
MalaCardsiJRK.
Orphaneti64280. Childhood absence epilepsy.
307. Juvenile myoclonic epilepsy.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001261281 – 520Jerky protein homologAdd BLAST520

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei366PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO75564.
PeptideAtlasiO75564.
PRIDEiO75564.

PTM databases

iPTMnetiO75564.
PhosphoSitePlusiO75564.

Expressioni

Tissue specificityi

Expressed ubiquitously.1 Publication

Gene expression databases

CleanExiHS_JRK.

Organism-specific databases

HPAiCAB015418.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CTNNB1P352223EBI-8607681,EBI-491549
Lef1P277823EBI-8607681,EBI-984464From a different organism.

Protein-protein interaction databases

IntActiO75564. 4 interactors.
MINTiMINT-8176614.

Structurei

3D structure databases

ProteinModelPortaliO75564.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 101HTH CENPB-typePROSITE-ProRule annotationAdd BLAST73
Domaini130 – 334DDE-1Add BLAST205

Sequence similaritiesi

Contains 1 DDE-1 domain.
Contains 1 HTH CENPB-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG052163.
InParanoidiO75564.
PhylomeDBiO75564.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR004875. DDE_SF_endonuclease_dom.
IPR009057. Homeodomain-like.
IPR006600. HTH_CenpB_DNA-bd_dom.
[Graphical view]
PfamiPF03184. DDE_1. 1 hit.
PF03221. HTH_Tnp_Tc5. 1 hit.
[Graphical view]
SMARTiSM00674. CENPB. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51253. HTH_CENPB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O75564-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTLYDIRAH KAQLLRFFAS SDSNKALEQR RTLHTPKLEH LDRVLYEWFL
60 70 80 90 100
GKRSEGVPVS GPMLIEKAKD FYEQMQLTEP CVFSGGWLWR FKARHGIKKL
110 120 130 140 150
DASSEKQSAD HQAAEQFCAF FRSLAAEHGL SAEQVYNADE TGLFWRCLPN
160 170 180 190 200
PTPEGGAVPG PKQGKDRLTV LMCANATGSH RLKPLAIGKC SGPRAFKGIQ
210 220 230 240 250
HLPVAYKAQG NAWVDKEIFS DWFHHIFVPS VREHFRTIGL PEDSKAVLLL
260 270 280 290 300
DSSRAHPQEA ELVSSNVFTI FLPASVASLV QPMEQGIRRD FMRNFINPPV
310 320 330 340 350
PLQGPHARYN MNDAIFSVAC AWNAVPSHVF RRAWRKLWPS VAFAEGSSSE
360 370 380 390 400
EELEAECFPV KPHNKSFAHI LELVKEGSSC PGQLRQRQAA SWGVAGREAE
410 420 430 440 450
GGRPPAATSP AEVVWSSEKT PKADQDGRGD PGEGEEVAWE QAAVAFDAVL
460 470 480 490 500
RFAERQPCFS AQEVGQLRAL RAVFRSQQQV RRRRGALGAV VKVEALQEGP
510 520
GGCGATAQSP LPCSSTAGDN
Length:520
Mass (Da):57,402
Last modified:January 17, 2003 - v2
Checksum:i66C0A2E31DD17C98
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti428R → G in AAC32353 (PubMed:9675132).Curated1
Sequence conflicti480 – 520VRRRR…TAGDN → ETVGLEDVVVTSPEELAIPK CCLEASTET in AAC32353 (PubMed:9675132).CuratedAdd BLAST41

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF072467 mRNA. Translation: AAC32352.1.
AF072468 mRNA. Translation: AAC32353.1.
UniGeneiHs.535903.
Hs.683465.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF072467 mRNA. Translation: AAC32352.1.
AF072468 mRNA. Translation: AAC32353.1.
UniGeneiHs.535903.
Hs.683465.

3D structure databases

ProteinModelPortaliO75564.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO75564. 4 interactors.
MINTiMINT-8176614.

PTM databases

iPTMnetiO75564.
PhosphoSitePlusiO75564.

Proteomic databases

MaxQBiO75564.
PeptideAtlasiO75564.
PRIDEiO75564.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

DisGeNETi8629.
GeneCardsiJRK.
HGNCiHGNC:6199. JRK.
HPAiCAB015418.
MalaCardsiJRK.
MIMi603210. gene.
neXtProtiNX_O75564.
Orphaneti64280. Childhood absence epilepsy.
307. Juvenile myoclonic epilepsy.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG052163.
InParanoidiO75564.
PhylomeDBiO75564.

Enzyme and pathway databases

BioCyciZFISH:G66-31142-MONOMER.

Miscellaneous databases

PROiO75564.
SOURCEiSearch...

Gene expression databases

CleanExiHS_JRK.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR004875. DDE_SF_endonuclease_dom.
IPR009057. Homeodomain-like.
IPR006600. HTH_CenpB_DNA-bd_dom.
[Graphical view]
PfamiPF03184. DDE_1. 1 hit.
PF03221. HTH_Tnp_Tc5. 1 hit.
[Graphical view]
SMARTiSM00674. CENPB. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51253. HTH_CENPB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiJERKY_HUMAN
AccessioniPrimary (citable) accession number: O75564
Secondary accession number(s): O75565
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: January 17, 2003
Last modified: November 30, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.