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O75564

- JERKY_HUMAN

UniProt

O75564 - JERKY_HUMAN

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Protein

Jerky protein homolog

Gene

JRK

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

May bind DNA.By similarity

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Jerky protein homolog
Gene namesi
Name:JRK
Synonyms:JH8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:6199. JRK.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

Orphaneti64280. Childhood absence epilepsy.
307. Juvenile myoclonic epilepsy.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 520520Jerky protein homologPRO_0000126128Add
BLAST

Proteomic databases

MaxQBiO75564.
PaxDbiO75564.
PRIDEiO75564.

Expressioni

Tissue specificityi

Expressed ubiquitously.1 Publication

Gene expression databases

CleanExiHS_JRK.
ExpressionAtlasiO75564. baseline and differential.
GenevestigatoriO75564.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CTNNB1P352223EBI-8607681,EBI-491549
Lef1P277823EBI-8607681,EBI-984464From a different organism.

Protein-protein interaction databases

IntActiO75564. 4 interactions.
MINTiMINT-8176614.
STRINGi9606.ENSP00000406898.

Structurei

3D structure databases

ProteinModelPortaliO75564.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 10173HTH CENPB-typePROSITE-ProRule annotationAdd
BLAST
Domaini130 – 334205DDEAdd
BLAST

Sequence similaritiesi

Contains 1 DDE domain.Curated
Contains 1 HTH CENPB-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG308602.
HOVERGENiHBG052163.
InParanoidiO75564.
PhylomeDBiO75564.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR004875. DDE_SF_endonuclease_CENPB-like.
IPR009057. Homeodomain-like.
IPR006600. HTH_CenpB_DNA-bd_dom.
[Graphical view]
PfamiPF03184. DDE_1. 1 hit.
PF03221. HTH_Tnp_Tc5. 1 hit.
[Graphical view]
SMARTiSM00674. CENPB. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51253. HTH_CENPB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O75564-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTLYDIRAH KAQLLRFFAS SDSNKALEQR RTLHTPKLEH LDRVLYEWFL
60 70 80 90 100
GKRSEGVPVS GPMLIEKAKD FYEQMQLTEP CVFSGGWLWR FKARHGIKKL
110 120 130 140 150
DASSEKQSAD HQAAEQFCAF FRSLAAEHGL SAEQVYNADE TGLFWRCLPN
160 170 180 190 200
PTPEGGAVPG PKQGKDRLTV LMCANATGSH RLKPLAIGKC SGPRAFKGIQ
210 220 230 240 250
HLPVAYKAQG NAWVDKEIFS DWFHHIFVPS VREHFRTIGL PEDSKAVLLL
260 270 280 290 300
DSSRAHPQEA ELVSSNVFTI FLPASVASLV QPMEQGIRRD FMRNFINPPV
310 320 330 340 350
PLQGPHARYN MNDAIFSVAC AWNAVPSHVF RRAWRKLWPS VAFAEGSSSE
360 370 380 390 400
EELEAECFPV KPHNKSFAHI LELVKEGSSC PGQLRQRQAA SWGVAGREAE
410 420 430 440 450
GGRPPAATSP AEVVWSSEKT PKADQDGRGD PGEGEEVAWE QAAVAFDAVL
460 470 480 490 500
RFAERQPCFS AQEVGQLRAL RAVFRSQQQV RRRRGALGAV VKVEALQEGP
510 520
GGCGATAQSP LPCSSTAGDN
Length:520
Mass (Da):57,402
Last modified:January 17, 2003 - v2
Checksum:i66C0A2E31DD17C98
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti428 – 4281R → G in AAC32353. (PubMed:9675132)Curated
Sequence conflicti480 – 52041VRRRR…TAGDN → ETVGLEDVVVTSPEELAIPK CCLEASTET in AAC32353. (PubMed:9675132)CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF072467 mRNA. Translation: AAC32352.1.
AF072468 mRNA. Translation: AAC32353.1.
UniGeneiHs.535903.
Hs.683465.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF072467 mRNA. Translation: AAC32352.1 .
AF072468 mRNA. Translation: AAC32353.1 .
UniGenei Hs.535903.
Hs.683465.

3D structure databases

ProteinModelPortali O75564.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O75564. 4 interactions.
MINTi MINT-8176614.
STRINGi 9606.ENSP00000406898.

Proteomic databases

MaxQBi O75564.
PaxDbi O75564.
PRIDEi O75564.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

GeneCardsi GC08M143735.
HGNCi HGNC:6199. JRK.
MIMi 603210. gene.
neXtProti NX_O75564.
Orphaneti 64280. Childhood absence epilepsy.
307. Juvenile myoclonic epilepsy.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG308602.
HOVERGENi HBG052163.
InParanoidi O75564.
PhylomeDBi O75564.

Miscellaneous databases

PROi O75564.
SOURCEi Search...

Gene expression databases

CleanExi HS_JRK.
ExpressionAtlasi O75564. baseline and differential.
Genevestigatori O75564.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR004875. DDE_SF_endonuclease_CENPB-like.
IPR009057. Homeodomain-like.
IPR006600. HTH_CenpB_DNA-bd_dom.
[Graphical view ]
Pfami PF03184. DDE_1. 1 hit.
PF03221. HTH_Tnp_Tc5. 1 hit.
[Graphical view ]
SMARTi SM00674. CENPB. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS51253. HTH_CENPB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "JH8, a gene highly homologous to the mouse jerky gene, maps to the region for childhood absence epilepsy on 8q24."
    Morita R., Miyazaki E., Fong C.-Y.G., Chen X.-N., Korenberg J.R., Delgado-Escueta A.V., Yamakawa K.
    Biochem. Biophys. Res. Commun. 248:307-314(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Fetal brain.

Entry informationi

Entry nameiJERKY_HUMAN
AccessioniPrimary (citable) accession number: O75564
Secondary accession number(s): O75565
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: January 17, 2003
Last modified: October 29, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3