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Protein

Syntaxin-11

Gene

STX11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-11
Gene namesi
Name:STX11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:11429. STX11.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Involvement in diseasei

Familial hemophagocytic lymphohistiocytosis 4 (FHL4)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare disorder characterized by immune dysregulation with hypercytokinemia, defective function of natural killer cell, and massive infiltration of several organs by activated lymphocytes and macrophages. The clinical features of the disease include fever, hepatosplenomegaly, cytopenia, and less frequently neurological abnormalities ranging from irritability and hypotonia to seizures, cranial nerve deficits and ataxia.
See also OMIM:603552

Keywords - Diseasei

Familial hemophagocytic lymphohistiocytosis

Organism-specific databases

DisGeNETi8676.
MalaCardsiSTX11.
MIMi603552. phenotype.
OpenTargetsiENSG00000135604.
Orphaneti540. Familial hemophagocytic lymphohistiocytosis.
PharmGKBiPA36229.

Polymorphism and mutation databases

BioMutaiSTX11.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002102211 – 287Syntaxin-11Add BLAST287

Proteomic databases

EPDiO75558.
MaxQBiO75558.
PaxDbiO75558.
PeptideAtlasiO75558.
PRIDEiO75558.

2D gel databases

OGPiO75558.

PTM databases

iPTMnetiO75558.
PhosphoSitePlusiO75558.
SwissPalmiO75558.

Expressioni

Gene expression databases

BgeeiENSG00000135604.
CleanExiHS_STX11.
GenevisibleiO75558. HS.

Organism-specific databases

HPAiHPA007992.
HPA076253.

Interactioni

Subunit structurei

Interacts with the SNARE proteins SNAP-23 and VAMP.

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114224. 102 interactors.
IntActiO75558. 87 interactors.
MINTiMINT-1398569.
STRINGi9606.ENSP00000356540.

Structurei

3D structure databases

ProteinModelPortaliO75558.
SMRiO75558.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini204 – 266t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili41 – 71Sequence analysisAdd BLAST31

Sequence similaritiesi

Belongs to the syntaxin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0810. Eukaryota.
COG5074. LUCA.
GeneTreeiENSGT00760000119200.
HOGENOMiHOG000286023.
HOVERGENiHBG099780.
InParanoidiO75558.
KOiK08487.
OMAiKIRIQRQ.
OrthoDBiEOG091G0K4L.
PhylomeDBiO75558.
TreeFamiTF313763.

Family and domain databases

InterProiView protein in InterPro
IPR010989. SNARE.
IPR028672. STX11.
IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR000727. T_SNARE_dom.
PANTHERiPTHR19957:SF146. PTHR19957:SF146. 1 hit.
PfamiView protein in Pfam
PF00804. Syntaxin. 1 hit.
SMARTiView protein in SMART
SM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiView protein in PROSITE
PS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.

Sequencei

Sequence statusi: Complete.

O75558-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDRLAELLD LSKQYDQQFP DGDDEFDSPH EDIVFETDHI LESLYRDIRD
60 70 80 90 100
IQDENQLLVA DVKRLGKQNA RFLTSMRRLS SIKRDTNSIA KAIKARGEVI
110 120 130 140 150
HCKLRAMKEL SEAAEAQHGP HSAVARISRA QYNALTLTFQ RAMHDYNQAE
160 170 180 190 200
MKQRDNCKIR IQRQLEIMGK EVSGDQIEDM FEQGKWDVFS ENLLADVKGA
210 220 230 240 250
RAALNEIESR HRELLRLESR IRDVHELFLQ MAVLVEKQAD TLNVIELNVQ
260 270 280
KTVDYTGQAK AQVRKAVQYE EKNPCRTLCC FCCPCLK
Length:287
Mass (Da):33,196
Last modified:November 1, 1998 - v1
Checksum:i18E8B43BA987D891
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti61D → N in AAD02107 (PubMed:9571206).Curated1
Sequence conflicti93 – 94IK → FR in AAC24031 (PubMed:9553086).Curated2
Sequence conflicti96 – 97RG → PP in AAD02107 (PubMed:9571206).Curated2
Sequence conflicti103 – 104KL → NV in AAD02107 (PubMed:9571206).Curated2
Sequence conflicti121 – 126HSAVAR → ALGSGG in AAD02107 (PubMed:9571206).Curated6
Sequence conflicti200 – 220ARAAL…RLESR → RGPPTTRSRAATANCCAWRA A in AAC24031 (PubMed:9553086).CuratedAdd BLAST21
Sequence conflicti200A → V in AAD02107 (PubMed:9571206).Curated1
Sequence conflicti215L → V in AAD02107 (PubMed:9571206).Curated1
Sequence conflicti220R → A in AAD02107 (PubMed:9571206).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01199531E → Q. Corresponds to variant dbSNP:rs1802414Ensembl.1
Natural variantiVAR_02976949R → Q. Corresponds to variant dbSNP:rs17073498Ensembl.1
Natural variantiVAR_011996204L → H. Corresponds to variant dbSNP:rs1133248Ensembl.1
Natural variantiVAR_029770277T → A. Corresponds to variant dbSNP:rs9496891Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038898 mRNA. Translation: AAD02107.1.
AF044309 mRNA. Translation: AAC24031.1.
AF071504 mRNA. Translation: AAC24004.1.
AL135917 Genomic DNA. Translation: CAI22980.1.
CH471051 Genomic DNA. Translation: EAW47849.1.
CH471051 Genomic DNA. Translation: EAW47850.1.
BC033519 mRNA. Translation: AAH33519.1.
CCDSiCCDS5205.1.
PIRiJE0094.
RefSeqiNP_003755.2. NM_003764.3.
XP_011534516.1. XM_011536214.2.
XP_011534519.1. XM_011536217.2.
XP_011534520.1. XM_011536218.2.
XP_016866889.1. XM_017011400.1.
UniGeneiHs.118958.

Genome annotation databases

EnsembliENST00000367568; ENSP00000356540; ENSG00000135604.
GeneIDi8676.
KEGGihsa:8676.
UCSCiuc003qks.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

STX11base

STX11 mutation db

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038898 mRNA. Translation: AAD02107.1.
AF044309 mRNA. Translation: AAC24031.1.
AF071504 mRNA. Translation: AAC24004.1.
AL135917 Genomic DNA. Translation: CAI22980.1.
CH471051 Genomic DNA. Translation: EAW47849.1.
CH471051 Genomic DNA. Translation: EAW47850.1.
BC033519 mRNA. Translation: AAH33519.1.
CCDSiCCDS5205.1.
PIRiJE0094.
RefSeqiNP_003755.2. NM_003764.3.
XP_011534516.1. XM_011536214.2.
XP_011534519.1. XM_011536217.2.
XP_011534520.1. XM_011536218.2.
XP_016866889.1. XM_017011400.1.
UniGeneiHs.118958.

3D structure databases

ProteinModelPortaliO75558.
SMRiO75558.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114224. 102 interactors.
IntActiO75558. 87 interactors.
MINTiMINT-1398569.
STRINGi9606.ENSP00000356540.

PTM databases

iPTMnetiO75558.
PhosphoSitePlusiO75558.
SwissPalmiO75558.

Polymorphism and mutation databases

BioMutaiSTX11.

2D gel databases

OGPiO75558.

Proteomic databases

EPDiO75558.
MaxQBiO75558.
PaxDbiO75558.
PeptideAtlasiO75558.
PRIDEiO75558.

Protocols and materials databases

DNASUi8676.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367568; ENSP00000356540; ENSG00000135604.
GeneIDi8676.
KEGGihsa:8676.
UCSCiuc003qks.5. human.

Organism-specific databases

CTDi8676.
DisGeNETi8676.
GeneCardsiSTX11.
GeneReviewsiSTX11.
HGNCiHGNC:11429. STX11.
HPAiHPA007992.
HPA076253.
MalaCardsiSTX11.
MIMi603552. phenotype.
605014. gene.
neXtProtiNX_O75558.
OpenTargetsiENSG00000135604.
Orphaneti540. Familial hemophagocytic lymphohistiocytosis.
PharmGKBiPA36229.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0810. Eukaryota.
COG5074. LUCA.
GeneTreeiENSGT00760000119200.
HOGENOMiHOG000286023.
HOVERGENiHBG099780.
InParanoidiO75558.
KOiK08487.
OMAiKIRIQRQ.
OrthoDBiEOG091G0K4L.
PhylomeDBiO75558.
TreeFamiTF313763.

Miscellaneous databases

ChiTaRSiSTX11. human.
GeneWikiiSTX11.
GenomeRNAii8676.
PROiPR:O75558.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000135604.
CleanExiHS_STX11.
GenevisibleiO75558. HS.

Family and domain databases

InterProiView protein in InterPro
IPR010989. SNARE.
IPR028672. STX11.
IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR000727. T_SNARE_dom.
PANTHERiPTHR19957:SF146. PTHR19957:SF146. 1 hit.
PfamiView protein in Pfam
PF00804. Syntaxin. 1 hit.
SMARTiView protein in SMART
SM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiView protein in PROSITE
PS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSTX11_HUMAN
AccessioniPrimary (citable) accession number: O75558
Secondary accession number(s): E1P598
, O75378, O95148, Q5TCL6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: June 7, 2017
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.