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O75558

- STX11_HUMAN

UniProt

O75558 - STX11_HUMAN

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Protein
Syntaxin-11
Gene
STX11
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network.

GO - Molecular functioni

  1. SNAP receptor activity Source: ProtInc
  2. protein binding Source: UniProtKB

GO - Biological processi

  1. cytotoxic T cell degranulation Source: Ensembl
  2. intracellular protein transport Source: InterPro
  3. membrane fusion Source: ProtInc
  4. natural killer cell degranulation Source: Ensembl
  5. neutrophil degranulation Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-11
Gene namesi
Name:STX11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:11429. STX11.

Subcellular locationi

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-SubCell
  2. membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Involvement in diseasei

Familial hemophagocytic lymphohistiocytosis 4 (FHL4) [MIM:603552]: A rare disorder characterized by immune dysregulation with hypercytokinemia, defective function of natural killer cell, and massive infiltration of several organs by activated lymphocytes and macrophages. The clinical features of the disease include fever, hepatosplenomegaly, cytopenia, and less frequently neurological abnormalities ranging from irritability and hypotonia to seizures, cranial nerve deficits and ataxia.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication

Keywords - Diseasei

Familial hemophagocytic lymphohistiocytosis

Organism-specific databases

MIMi603552. phenotype.
Orphaneti540. Familial hemophagocytic lymphohistiocytosis.
PharmGKBiPA36229.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 287287Syntaxin-11
PRO_0000210221Add
BLAST

Proteomic databases

MaxQBiO75558.
PaxDbiO75558.
PRIDEiO75558.

2D gel databases

OGPiO75558.

PTM databases

PhosphoSiteiO75558.

Expressioni

Gene expression databases

BgeeiO75558.
CleanExiHS_STX11.
GenevestigatoriO75558.

Organism-specific databases

HPAiHPA007992.

Interactioni

Subunit structurei

Interacts with the SNARE proteins SNAP-23 and VAMP.

Protein-protein interaction databases

BioGridi114224. 20 interactions.
IntActiO75558. 15 interactions.
MINTiMINT-1398569.
STRINGi9606.ENSP00000356540.

Structurei

3D structure databases

ProteinModelPortaliO75558.
SMRiO75558. Positions 38-259.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini204 – 26663t-SNARE coiled-coil homology
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili41 – 7131 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Belongs to the syntaxin family.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG306476.
HOGENOMiHOG000286023.
HOVERGENiHBG099780.
InParanoidiO75558.
KOiK08487.
OMAiPHEDIVF.
OrthoDBiEOG7X9G7R.
PhylomeDBiO75558.
TreeFamiTF313763.

Family and domain databases

InterProiIPR028672. STX11.
IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PANTHERiPTHR19957:SF30. PTHR19957:SF30. 1 hit.
PfamiPF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view]
SMARTiSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O75558-1 [UniParc]FASTAAdd to Basket

« Hide

MKDRLAELLD LSKQYDQQFP DGDDEFDSPH EDIVFETDHI LESLYRDIRD    50
IQDENQLLVA DVKRLGKQNA RFLTSMRRLS SIKRDTNSIA KAIKARGEVI 100
HCKLRAMKEL SEAAEAQHGP HSAVARISRA QYNALTLTFQ RAMHDYNQAE 150
MKQRDNCKIR IQRQLEIMGK EVSGDQIEDM FEQGKWDVFS ENLLADVKGA 200
RAALNEIESR HRELLRLESR IRDVHELFLQ MAVLVEKQAD TLNVIELNVQ 250
KTVDYTGQAK AQVRKAVQYE EKNPCRTLCC FCCPCLK 287
Length:287
Mass (Da):33,196
Last modified:November 1, 1998 - v1
Checksum:i18E8B43BA987D891
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti31 – 311E → Q.
Corresponds to variant rs1802414 [ dbSNP | Ensembl ].
VAR_011995
Natural varianti49 – 491R → Q.
Corresponds to variant rs17073498 [ dbSNP | Ensembl ].
VAR_029769
Natural varianti204 – 2041L → H.
Corresponds to variant rs1133248 [ dbSNP | Ensembl ].
VAR_011996
Natural varianti277 – 2771T → A.
Corresponds to variant rs9496891 [ dbSNP | Ensembl ].
VAR_029770

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti61 – 611D → N in AAD02107. 1 Publication
Sequence conflicti93 – 942IK → FR in AAC24031. 1 Publication
Sequence conflicti96 – 972RG → PP in AAD02107. 1 Publication
Sequence conflicti103 – 1042KL → NV in AAD02107. 1 Publication
Sequence conflicti121 – 1266HSAVAR → ALGSGG in AAD02107. 1 Publication
Sequence conflicti200 – 22021ARAAL…RLESR → RGPPTTRSRAATANCCAWRA A in AAC24031. 1 Publication
Add
BLAST
Sequence conflicti200 – 2001A → V in AAD02107. 1 Publication
Sequence conflicti215 – 2151L → V in AAD02107. 1 Publication
Sequence conflicti220 – 2201R → A in AAD02107. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF038898 mRNA. Translation: AAD02107.1.
AF044309 mRNA. Translation: AAC24031.1.
AF071504 mRNA. Translation: AAC24004.1.
AL135917 Genomic DNA. Translation: CAI22980.1.
CH471051 Genomic DNA. Translation: EAW47849.1.
CH471051 Genomic DNA. Translation: EAW47850.1.
BC033519 mRNA. Translation: AAH33519.1.
CCDSiCCDS5205.1.
PIRiJE0094.
RefSeqiNP_003755.2. NM_003764.3.
XP_005267246.1. XM_005267189.1.
XP_006715651.1. XM_006715588.1.
UniGeneiHs.118958.

Genome annotation databases

EnsembliENST00000367568; ENSP00000356540; ENSG00000135604.
GeneIDi8676.
KEGGihsa:8676.
UCSCiuc003qks.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

STX11base

STX11 mutation db

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF038898 mRNA. Translation: AAD02107.1 .
AF044309 mRNA. Translation: AAC24031.1 .
AF071504 mRNA. Translation: AAC24004.1 .
AL135917 Genomic DNA. Translation: CAI22980.1 .
CH471051 Genomic DNA. Translation: EAW47849.1 .
CH471051 Genomic DNA. Translation: EAW47850.1 .
BC033519 mRNA. Translation: AAH33519.1 .
CCDSi CCDS5205.1.
PIRi JE0094.
RefSeqi NP_003755.2. NM_003764.3.
XP_005267246.1. XM_005267189.1.
XP_006715651.1. XM_006715588.1.
UniGenei Hs.118958.

3D structure databases

ProteinModelPortali O75558.
SMRi O75558. Positions 38-259.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114224. 20 interactions.
IntActi O75558. 15 interactions.
MINTi MINT-1398569.
STRINGi 9606.ENSP00000356540.

PTM databases

PhosphoSitei O75558.

2D gel databases

OGPi O75558.

Proteomic databases

MaxQBi O75558.
PaxDbi O75558.
PRIDEi O75558.

Protocols and materials databases

DNASUi 8676.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000367568 ; ENSP00000356540 ; ENSG00000135604 .
GeneIDi 8676.
KEGGi hsa:8676.
UCSCi uc003qks.4. human.

Organism-specific databases

CTDi 8676.
GeneCardsi GC06P144513.
GeneReviewsi STX11.
HGNCi HGNC:11429. STX11.
HPAi HPA007992.
MIMi 603552. phenotype.
605014. gene.
neXtProti NX_O75558.
Orphaneti 540. Familial hemophagocytic lymphohistiocytosis.
PharmGKBi PA36229.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG306476.
HOGENOMi HOG000286023.
HOVERGENi HBG099780.
InParanoidi O75558.
KOi K08487.
OMAi PHEDIVF.
OrthoDBi EOG7X9G7R.
PhylomeDBi O75558.
TreeFami TF313763.

Miscellaneous databases

GeneWikii STX11.
GenomeRNAii 8676.
NextBioi 32547.
PROi O75558.
SOURCEi Search...

Gene expression databases

Bgeei O75558.
CleanExi HS_STX11.
Genevestigatori O75558.

Family and domain databases

InterProi IPR028672. STX11.
IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view ]
PANTHERi PTHR19957:SF30. PTHR19957:SF30. 1 hit.
Pfami PF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view ]
SMARTi SM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view ]
SUPFAMi SSF47661. SSF47661. 1 hit.
PROSITEi PS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Syntaxin 11: a member of the syntaxin family without a carboxyl terminal transmembrane domain."
    Tang B.L., Low D.Y.H., Hong W.
    Biochem. Biophys. Res. Commun. 245:627-632(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Seven novel mammalian SNARE proteins localize to distinct membrane compartments."
    Advani R.J., Bae H.-R., Bock J.B., Chao D.S., Doung Y.-C., Prekeris R., Yoo J.-S., Scheller R.H.
    J. Biol. Chem. 273:10317-10324(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Syntaxin 11 is associated with SNAP-23 on late endosomes and the trans-Golgi network."
    Valdez A.C., Cabaniols J.-P., Brown M.J., Roche P.A.
    J. Cell Sci. 112:845-854(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  7. "Linkage of familial hemophagocytic lymphohistiocytosis (FHL) type-4 to chromosome 6q24 and identification of mutations in syntaxin 11."
    zur Stadt U., Schmidt S., Kasper B., Beutel K., Diler A.S., Henter J.-I., Kabisch H., Schneppenheim R., Nuernberg P., Janka G., Hennies H.C.
    Hum. Mol. Genet. 14:827-834(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN FHL4.

Entry informationi

Entry nameiSTX11_HUMAN
AccessioniPrimary (citable) accession number: O75558
Secondary accession number(s): E1P598
, O75378, O95148, Q5TCL6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: July 9, 2014
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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