O75558 (STX11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Syntaxin-11

Gene names

Name:

STX11

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	287 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network.
Subunit structure	Interacts with the SNARE proteins SNAP-23 and VAMP.
Subcellular location	Membrane; Peripheral membrane protein Potential. Golgi apparatus › trans-Golgi network membrane; Peripheral membrane protein By similarity.
Involvement in disease	Familial hemophagocytic lymphohistiocytosis 4 (FHL4) [MIM:603552]: A rare disorder characterized by immune dysregulation with hypercytokinemia, defective function of natural killer cell, and massive infiltration of several organs by activated lymphocytes and macrophages. The clinical features of the disease include fever, hepatosplenomegaly, cytopenia, and less frequently neurological abnormalities ranging from irritability and hypotonia to seizures, cranial nerve deficits and ataxia. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.7
Sequence similarities	Belongs to the syntaxin family. Contains 1 t-SNARE coiled-coil homology domain.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Golgi apparatus Membrane
Coding sequence diversity	Polymorphism
Disease	Familial hemophagocytic lymphohistiocytosis
Domain	Coiled coil
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular membrane fusion Traceable author statement Ref.2. Source: ProtInc intracellular protein transport Inferred from electronic annotation. Source: InterPro vesicle-mediated transport Inferred from electronic annotation. Source: InterPro
Cellular_component	Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	SNAP receptor activity Traceable author statement Ref.2. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 287	287	Syntaxin-11		PRO_0000210221
Regions
	Domain	204 – 266	63	t-SNARE coiled-coil homology
	Coiled coil	41 – 71	31	Potential
Natural variations
	Natural variant	31	1	E → Q. Corresponds to variant rs1802414 [ dbSNP | Ensembl ].		VAR_011995
	Natural variant	49	1	R → Q. Corresponds to variant rs17073498 [ dbSNP | Ensembl ].		VAR_029769
	Natural variant	204	1	L → H. Corresponds to variant rs1133248 [ dbSNP | Ensembl ].		VAR_011996
	Natural variant	277	1	T → A. Corresponds to variant rs9496891 [ dbSNP | Ensembl ].		VAR_029770
Experimental info
	Sequence conflict	61	1	D → N in AAD02107. Ref.1
	Sequence conflict	93 – 94	2	IK → FR in AAC24031. Ref.2
	Sequence conflict	96 – 97	2	RG → PP in AAD02107. Ref.1
	Sequence conflict	103 – 104	2	KL → NV in AAD02107. Ref.1
	Sequence conflict	121 – 126	6	HSAVAR → ALGSGG in AAD02107. Ref.1
	Sequence conflict	200 – 220	21	ARAAL…RLESR → RGPPTTRSRAATANCCAWRA A in AAC24031. Ref.2
	Sequence conflict	200	1	A → V in AAD02107. Ref.1
	Sequence conflict	215	1	L → V in AAD02107. Ref.1
	Sequence conflict	220	1	R → A in AAD02107. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	O75558 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 18E8B43BA987D891	FASTA	287	33,196
	10 20 30 40 50 60 MKDRLAELLD LSKQYDQQFP DGDDEFDSPH EDIVFETDHI LESLYRDIRD IQDENQLLVA 70 80 90 100 110 120 DVKRLGKQNA RFLTSMRRLS SIKRDTNSIA KAIKARGEVI HCKLRAMKEL SEAAEAQHGP 130 140 150 160 170 180 HSAVARISRA QYNALTLTFQ RAMHDYNQAE MKQRDNCKIR IQRQLEIMGK EVSGDQIEDM 190 200 210 220 230 240 FEQGKWDVFS ENLLADVKGA RAALNEIESR HRELLRLESR IRDVHELFLQ MAVLVEKQAD 250 260 270 280 TLNVIELNVQ KTVDYTGQAK AQVRKAVQYE EKNPCRTLCC FCCPCLK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Syntaxin 11: a member of the syntaxin family without a carboxyl terminal transmembrane domain." Tang B.L., Low D.Y.H., Hong W. Biochem. Biophys. Res. Commun. 245:627-632(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Seven novel mammalian SNARE proteins localize to distinct membrane compartments." Advani R.J., Bae H.-R., Bock J.B., Chao D.S., Doung Y.-C., Prekeris R., Yoo J.-S., Scheller R.H. J. Biol. Chem. 273:10317-10324(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Syntaxin 11 is associated with SNAP-23 on late endosomes and the trans-Golgi network." Valdez A.C., Cabaniols J.-P., Brown M.J., Roche P.A. J. Cell Sci. 112:845-854(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Placenta.
[4]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[7]	"Linkage of familial hemophagocytic lymphohistiocytosis (FHL) type-4 to chromosome 6q24 and identification of mutations in syntaxin 11." zur Stadt U., Schmidt S., Kasper B., Beutel K., Diler A.S., Henter J.-I., Kabisch H., Schneppenheim R., Nuernberg P., Janka G., Hennies H.C. Hum. Mol. Genet. 14:827-834(2005) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN FHL4.
+	Additional computationally mapped references.

Web resources

STX11base

STX11 mutation db

GeneReviews

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF038898 mRNA. Translation: AAD02107.1. AF044309 mRNA. Translation: AAC24031.1. AF071504 mRNA. Translation: AAC24004.1. AL135917 Genomic DNA. Translation: CAI22980.1. CH471051 Genomic DNA. Translation: EAW47849.1. CH471051 Genomic DNA. Translation: EAW47850.1. BC033519 mRNA. Translation: AAH33519.1.
IPI	IPI00026128.
PIR	JE0094.
RefSeq	NP_003755.2. NM_003764.3.
UniGene	Hs.118958.
3D structure databases
ProteinModelPortal	O75558.
ModBase	Search...
Protein-protein interaction databases
IntAct	O75558. 12 interactions.
MINT	MINT-1398569.
STRING	9606.ENSP00000356540.
PTM databases
PhosphoSite	O75558.
2D gel databases
OGP	O75558.
Proteomic databases
PaxDb	O75558.
PRIDE	O75558.
Protocols and materials databases
DNASU	8676.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000367568; ENSP00000356540; ENSG00000135604.
GeneID	8676.
KEGG	hsa:8676.
UCSC	uc003qks.4. human.
Organism-specific databases
CTD	8676.
GeneCards	GC06P144513.
HGNC	HGNC:11429. STX11.
HPA	HPA007992.
MIM	603552. phenotype. 605014. gene.
neXtProt	NX_O75558.
Orphanet	540. Familial hemophagocytic lymphohistiocytosis.
PharmGKB	PA36229.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG306476.
HOGENOM	HOG000286023.
HOVERGEN	HBG099780.
InParanoid	O75558.
KO	K08487.
OMA	PHEDIVF.
OrthoDB	EOG4W9J4Q.
PhylomeDB	O75558.
Enzyme and pathway databases
Reactome	REACT_116125. Disease. REACT_13685. Neuronal System.
Gene expression databases
Bgee	O75558.
CleanEx	HS_STX11.
Genevestigator	O75558.
GermOnline	ENSG00000135604. Homo sapiens.
Family and domain databases
InterPro	IPR006012. Syntaxin/epimorphin_CS. IPR006011. Syntaxin_N. IPR010989. t-SNARE. IPR000727. T_SNARE_dom. [Graphical view]
Pfam	PF05739. SNARE. 1 hit. PF00804. Syntaxin. 1 hit. [Graphical view]
SMART	SM00503. SynN. 1 hit. SM00397. t_SNARE. 1 hit. [Graphical view]
SUPFAM	SSF47661. t-snare. 1 hit.
PROSITE	PS00914. SYNTAXIN. 1 hit. PS50192. T_SNARE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	8676.
NextBio	32547.
SOURCE	Search...

Entry information

Entry name

STX11_HUMAN

Accession

Primary (citable) accession number: O75558
Secondary accession number(s): E1P598 , O75378, O95148, Q5TCL6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	November 1, 1998
Last modified:	May 1, 2013
This is version 115 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.