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O75558

- STX11_HUMAN

UniProt

O75558 - STX11_HUMAN

Protein

Syntaxin-11

Gene

STX11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network.

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. SNAP receptor activity Source: ProtInc

    GO - Biological processi

    1. cytotoxic T cell degranulation Source: Ensembl
    2. intracellular protein transport Source: InterPro
    3. membrane fusion Source: ProtInc
    4. natural killer cell degranulation Source: Ensembl
    5. neutrophil degranulation Source: Ensembl

    Keywords - Biological processi

    Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Syntaxin-11
    Gene namesi
    Name:STX11
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:11429. STX11.

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB-SubCell
    2. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Familial hemophagocytic lymphohistiocytosis 4 (FHL4) [MIM:603552]: A rare disorder characterized by immune dysregulation with hypercytokinemia, defective function of natural killer cell, and massive infiltration of several organs by activated lymphocytes and macrophages. The clinical features of the disease include fever, hepatosplenomegaly, cytopenia, and less frequently neurological abnormalities ranging from irritability and hypotonia to seizures, cranial nerve deficits and ataxia.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Keywords - Diseasei

    Familial hemophagocytic lymphohistiocytosis

    Organism-specific databases

    MIMi603552. phenotype.
    Orphaneti540. Familial hemophagocytic lymphohistiocytosis.
    PharmGKBiPA36229.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 287287Syntaxin-11PRO_0000210221Add
    BLAST

    Proteomic databases

    MaxQBiO75558.
    PaxDbiO75558.
    PRIDEiO75558.

    2D gel databases

    OGPiO75558.

    PTM databases

    PhosphoSiteiO75558.

    Expressioni

    Gene expression databases

    BgeeiO75558.
    CleanExiHS_STX11.
    GenevestigatoriO75558.

    Organism-specific databases

    HPAiHPA007992.

    Interactioni

    Subunit structurei

    Interacts with the SNARE proteins SNAP-23 and VAMP.

    Protein-protein interaction databases

    BioGridi114224. 20 interactions.
    IntActiO75558. 15 interactions.
    MINTiMINT-1398569.
    STRINGi9606.ENSP00000356540.

    Structurei

    3D structure databases

    ProteinModelPortaliO75558.
    SMRiO75558. Positions 38-259.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini204 – 26663t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili41 – 7131Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the syntaxin family.Curated
    Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG306476.
    HOGENOMiHOG000286023.
    HOVERGENiHBG099780.
    InParanoidiO75558.
    KOiK08487.
    OMAiPHEDIVF.
    OrthoDBiEOG7X9G7R.
    PhylomeDBiO75558.
    TreeFamiTF313763.

    Family and domain databases

    InterProiIPR028672. STX11.
    IPR006012. Syntaxin/epimorphin_CS.
    IPR006011. Syntaxin_N.
    IPR010989. t-SNARE.
    IPR000727. T_SNARE_dom.
    [Graphical view]
    PANTHERiPTHR19957:SF30. PTHR19957:SF30. 1 hit.
    PfamiPF05739. SNARE. 1 hit.
    PF00804. Syntaxin. 1 hit.
    [Graphical view]
    SMARTiSM00503. SynN. 1 hit.
    SM00397. t_SNARE. 1 hit.
    [Graphical view]
    SUPFAMiSSF47661. SSF47661. 1 hit.
    PROSITEiPS00914. SYNTAXIN. 1 hit.
    PS50192. T_SNARE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O75558-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKDRLAELLD LSKQYDQQFP DGDDEFDSPH EDIVFETDHI LESLYRDIRD    50
    IQDENQLLVA DVKRLGKQNA RFLTSMRRLS SIKRDTNSIA KAIKARGEVI 100
    HCKLRAMKEL SEAAEAQHGP HSAVARISRA QYNALTLTFQ RAMHDYNQAE 150
    MKQRDNCKIR IQRQLEIMGK EVSGDQIEDM FEQGKWDVFS ENLLADVKGA 200
    RAALNEIESR HRELLRLESR IRDVHELFLQ MAVLVEKQAD TLNVIELNVQ 250
    KTVDYTGQAK AQVRKAVQYE EKNPCRTLCC FCCPCLK 287
    Length:287
    Mass (Da):33,196
    Last modified:November 1, 1998 - v1
    Checksum:i18E8B43BA987D891
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti61 – 611D → N in AAD02107. (PubMed:9571206)Curated
    Sequence conflicti93 – 942IK → FR in AAC24031. (PubMed:9553086)Curated
    Sequence conflicti96 – 972RG → PP in AAD02107. (PubMed:9571206)Curated
    Sequence conflicti103 – 1042KL → NV in AAD02107. (PubMed:9571206)Curated
    Sequence conflicti121 – 1266HSAVAR → ALGSGG in AAD02107. (PubMed:9571206)Curated
    Sequence conflicti200 – 22021ARAAL…RLESR → RGPPTTRSRAATANCCAWRA A in AAC24031. (PubMed:9553086)CuratedAdd
    BLAST
    Sequence conflicti200 – 2001A → V in AAD02107. (PubMed:9571206)Curated
    Sequence conflicti215 – 2151L → V in AAD02107. (PubMed:9571206)Curated
    Sequence conflicti220 – 2201R → A in AAD02107. (PubMed:9571206)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti31 – 311E → Q.
    Corresponds to variant rs1802414 [ dbSNP | Ensembl ].
    VAR_011995
    Natural varianti49 – 491R → Q.
    Corresponds to variant rs17073498 [ dbSNP | Ensembl ].
    VAR_029769
    Natural varianti204 – 2041L → H.
    Corresponds to variant rs1133248 [ dbSNP | Ensembl ].
    VAR_011996
    Natural varianti277 – 2771T → A.
    Corresponds to variant rs9496891 [ dbSNP | Ensembl ].
    VAR_029770

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF038898 mRNA. Translation: AAD02107.1.
    AF044309 mRNA. Translation: AAC24031.1.
    AF071504 mRNA. Translation: AAC24004.1.
    AL135917 Genomic DNA. Translation: CAI22980.1.
    CH471051 Genomic DNA. Translation: EAW47849.1.
    CH471051 Genomic DNA. Translation: EAW47850.1.
    BC033519 mRNA. Translation: AAH33519.1.
    CCDSiCCDS5205.1.
    PIRiJE0094.
    RefSeqiNP_003755.2. NM_003764.3.
    XP_005267246.1. XM_005267189.1.
    XP_006715651.1. XM_006715588.1.
    UniGeneiHs.118958.

    Genome annotation databases

    EnsembliENST00000367568; ENSP00000356540; ENSG00000135604.
    GeneIDi8676.
    KEGGihsa:8676.
    UCSCiuc003qks.4. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    STX11base

    STX11 mutation db

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF038898 mRNA. Translation: AAD02107.1 .
    AF044309 mRNA. Translation: AAC24031.1 .
    AF071504 mRNA. Translation: AAC24004.1 .
    AL135917 Genomic DNA. Translation: CAI22980.1 .
    CH471051 Genomic DNA. Translation: EAW47849.1 .
    CH471051 Genomic DNA. Translation: EAW47850.1 .
    BC033519 mRNA. Translation: AAH33519.1 .
    CCDSi CCDS5205.1.
    PIRi JE0094.
    RefSeqi NP_003755.2. NM_003764.3.
    XP_005267246.1. XM_005267189.1.
    XP_006715651.1. XM_006715588.1.
    UniGenei Hs.118958.

    3D structure databases

    ProteinModelPortali O75558.
    SMRi O75558. Positions 38-259.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114224. 20 interactions.
    IntActi O75558. 15 interactions.
    MINTi MINT-1398569.
    STRINGi 9606.ENSP00000356540.

    PTM databases

    PhosphoSitei O75558.

    2D gel databases

    OGPi O75558.

    Proteomic databases

    MaxQBi O75558.
    PaxDbi O75558.
    PRIDEi O75558.

    Protocols and materials databases

    DNASUi 8676.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000367568 ; ENSP00000356540 ; ENSG00000135604 .
    GeneIDi 8676.
    KEGGi hsa:8676.
    UCSCi uc003qks.4. human.

    Organism-specific databases

    CTDi 8676.
    GeneCardsi GC06P144513.
    GeneReviewsi STX11.
    HGNCi HGNC:11429. STX11.
    HPAi HPA007992.
    MIMi 603552. phenotype.
    605014. gene.
    neXtProti NX_O75558.
    Orphaneti 540. Familial hemophagocytic lymphohistiocytosis.
    PharmGKBi PA36229.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG306476.
    HOGENOMi HOG000286023.
    HOVERGENi HBG099780.
    InParanoidi O75558.
    KOi K08487.
    OMAi PHEDIVF.
    OrthoDBi EOG7X9G7R.
    PhylomeDBi O75558.
    TreeFami TF313763.

    Miscellaneous databases

    GeneWikii STX11.
    GenomeRNAii 8676.
    NextBioi 32547.
    PROi O75558.
    SOURCEi Search...

    Gene expression databases

    Bgeei O75558.
    CleanExi HS_STX11.
    Genevestigatori O75558.

    Family and domain databases

    InterProi IPR028672. STX11.
    IPR006012. Syntaxin/epimorphin_CS.
    IPR006011. Syntaxin_N.
    IPR010989. t-SNARE.
    IPR000727. T_SNARE_dom.
    [Graphical view ]
    PANTHERi PTHR19957:SF30. PTHR19957:SF30. 1 hit.
    Pfami PF05739. SNARE. 1 hit.
    PF00804. Syntaxin. 1 hit.
    [Graphical view ]
    SMARTi SM00503. SynN. 1 hit.
    SM00397. t_SNARE. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47661. SSF47661. 1 hit.
    PROSITEi PS00914. SYNTAXIN. 1 hit.
    PS50192. T_SNARE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Syntaxin 11: a member of the syntaxin family without a carboxyl terminal transmembrane domain."
      Tang B.L., Low D.Y.H., Hong W.
      Biochem. Biophys. Res. Commun. 245:627-632(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Seven novel mammalian SNARE proteins localize to distinct membrane compartments."
      Advani R.J., Bae H.-R., Bock J.B., Chao D.S., Doung Y.-C., Prekeris R., Yoo J.-S., Scheller R.H.
      J. Biol. Chem. 273:10317-10324(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Syntaxin 11 is associated with SNAP-23 on late endosomes and the trans-Golgi network."
      Valdez A.C., Cabaniols J.-P., Brown M.J., Roche P.A.
      J. Cell Sci. 112:845-854(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Placenta.
    4. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    7. "Linkage of familial hemophagocytic lymphohistiocytosis (FHL) type-4 to chromosome 6q24 and identification of mutations in syntaxin 11."
      zur Stadt U., Schmidt S., Kasper B., Beutel K., Diler A.S., Henter J.-I., Kabisch H., Schneppenheim R., Nuernberg P., Janka G., Hennies H.C.
      Hum. Mol. Genet. 14:827-834(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN FHL4.

    Entry informationi

    Entry nameiSTX11_HUMAN
    AccessioniPrimary (citable) accession number: O75558
    Secondary accession number(s): E1P598
    , O75378, O95148, Q5TCL6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 126 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3