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O75558 (STX11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Syntaxin-11
Gene names
Name:STX11
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length287 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network.

Subunit structure

Interacts with the SNARE proteins SNAP-23 and VAMP.

Subcellular location

Membrane; Peripheral membrane protein Potential. Golgi apparatustrans-Golgi network membrane; Peripheral membrane protein By similarity.

Involvement in disease

Familial hemophagocytic lymphohistiocytosis 4 (FHL4) [MIM:603552]: A rare disorder characterized by immune dysregulation with hypercytokinemia, defective function of natural killer cell, and massive infiltration of several organs by activated lymphocytes and macrophages. The clinical features of the disease include fever, hepatosplenomegaly, cytopenia, and less frequently neurological abnormalities ranging from irritability and hypotonia to seizures, cranial nerve deficits and ataxia.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.7

Sequence similarities

Belongs to the syntaxin family.

Contains 1 t-SNARE coiled-coil homology domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 287287Syntaxin-11
PRO_0000210221

Regions

Domain204 – 26663t-SNARE coiled-coil homology
Coiled coil41 – 7131 Potential

Natural variations

Natural variant311E → Q.
Corresponds to variant rs1802414 [ dbSNP | Ensembl ].
VAR_011995
Natural variant491R → Q.
Corresponds to variant rs17073498 [ dbSNP | Ensembl ].
VAR_029769
Natural variant2041L → H.
Corresponds to variant rs1133248 [ dbSNP | Ensembl ].
VAR_011996
Natural variant2771T → A.
Corresponds to variant rs9496891 [ dbSNP | Ensembl ].
VAR_029770

Experimental info

Sequence conflict611D → N in AAD02107. Ref.1
Sequence conflict93 – 942IK → FR in AAC24031. Ref.2
Sequence conflict96 – 972RG → PP in AAD02107. Ref.1
Sequence conflict103 – 1042KL → NV in AAD02107. Ref.1
Sequence conflict121 – 1266HSAVAR → ALGSGG in AAD02107. Ref.1
Sequence conflict200 – 22021ARAAL…RLESR → RGPPTTRSRAATANCCAWRA A in AAC24031. Ref.2
Sequence conflict2001A → V in AAD02107. Ref.1
Sequence conflict2151L → V in AAD02107. Ref.1
Sequence conflict2201R → A in AAD02107. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O75558 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 18E8B43BA987D891

FASTA28733,196
        10         20         30         40         50         60 
MKDRLAELLD LSKQYDQQFP DGDDEFDSPH EDIVFETDHI LESLYRDIRD IQDENQLLVA 

        70         80         90        100        110        120 
DVKRLGKQNA RFLTSMRRLS SIKRDTNSIA KAIKARGEVI HCKLRAMKEL SEAAEAQHGP 

       130        140        150        160        170        180 
HSAVARISRA QYNALTLTFQ RAMHDYNQAE MKQRDNCKIR IQRQLEIMGK EVSGDQIEDM 

       190        200        210        220        230        240 
FEQGKWDVFS ENLLADVKGA RAALNEIESR HRELLRLESR IRDVHELFLQ MAVLVEKQAD 

       250        260        270        280 
TLNVIELNVQ KTVDYTGQAK AQVRKAVQYE EKNPCRTLCC FCCPCLK 

« Hide

References

« Hide 'large scale' references
[1]"Syntaxin 11: a member of the syntaxin family without a carboxyl terminal transmembrane domain."
Tang B.L., Low D.Y.H., Hong W.
Biochem. Biophys. Res. Commun. 245:627-632(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Seven novel mammalian SNARE proteins localize to distinct membrane compartments."
Advani R.J., Bae H.-R., Bock J.B., Chao D.S., Doung Y.-C., Prekeris R., Yoo J.-S., Scheller R.H.
J. Biol. Chem. 273:10317-10324(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Syntaxin 11 is associated with SNAP-23 on late endosomes and the trans-Golgi network."
Valdez A.C., Cabaniols J.-P., Brown M.J., Roche P.A.
J. Cell Sci. 112:845-854(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Placenta.
[4]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[7]"Linkage of familial hemophagocytic lymphohistiocytosis (FHL) type-4 to chromosome 6q24 and identification of mutations in syntaxin 11."
zur Stadt U., Schmidt S., Kasper B., Beutel K., Diler A.S., Henter J.-I., Kabisch H., Schneppenheim R., Nuernberg P., Janka G., Hennies H.C.
Hum. Mol. Genet. 14:827-834(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN FHL4.
+Additional computationally mapped references.

Web resources

STX11base

STX11 mutation db

GeneReviews

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF038898 mRNA. Translation: AAD02107.1.
AF044309 mRNA. Translation: AAC24031.1.
AF071504 mRNA. Translation: AAC24004.1.
AL135917 Genomic DNA. Translation: CAI22980.1.
CH471051 Genomic DNA. Translation: EAW47849.1.
CH471051 Genomic DNA. Translation: EAW47850.1.
BC033519 mRNA. Translation: AAH33519.1.
PIRJE0094.
RefSeqNP_003755.2. NM_003764.3.
XP_005267246.1. XM_005267189.1.
UniGeneHs.118958.

3D structure databases

ProteinModelPortalO75558.
SMRO75558. Positions 38-259.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114224. 20 interactions.
IntActO75558. 15 interactions.
MINTMINT-1398569.
STRING9606.ENSP00000356540.

PTM databases

PhosphoSiteO75558.

2D gel databases

OGPO75558.

Proteomic databases

PaxDbO75558.
PRIDEO75558.

Protocols and materials databases

DNASU8676.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000367568; ENSP00000356540; ENSG00000135604.
GeneID8676.
KEGGhsa:8676.
UCSCuc003qks.4. human.

Organism-specific databases

CTD8676.
GeneCardsGC06P144513.
HGNCHGNC:11429. STX11.
HPAHPA007992.
MIM603552. phenotype.
605014. gene.
neXtProtNX_O75558.
Orphanet540. Familial hemophagocytic lymphohistiocytosis.
PharmGKBPA36229.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG306476.
HOGENOMHOG000286023.
HOVERGENHBG099780.
InParanoidO75558.
KOK08487.
OMAPHEDIVF.
OrthoDBEOG7X9G7R.
PhylomeDBO75558.
TreeFamTF313763.

Enzyme and pathway databases

ReactomeREACT_116125. Disease.
REACT_13685. Neuronal System.

Gene expression databases

BgeeO75558.
CleanExHS_STX11.
GenevestigatorO75558.

Family and domain databases

InterProIPR028672. STX11.
IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PANTHERPTHR19957:SF30. PTHR19957:SF30. 1 hit.
PfamPF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view]
SMARTSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMSSF47661. SSF47661. 1 hit.
PROSITEPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiSTX11.
GenomeRNAi8676.
NextBio32547.
PROO75558.
SOURCESearch...

Entry information

Entry nameSTX11_HUMAN
AccessionPrimary (citable) accession number: O75558
Secondary accession number(s): E1P598 expand/collapse secondary AC list , O75378, O95148, Q5TCL6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: April 16, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM