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Protein

Syntaxin-11

Gene

STX11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network.

GO - Molecular functioni

  • SNAP receptor activity Source: ProtInc
  • SNARE binding Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-11
Gene namesi
Name:STX11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:11429. STX11.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Involvement in diseasei

Familial hemophagocytic lymphohistiocytosis 4 (FHL4)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA rare disorder characterized by immune dysregulation with hypercytokinemia, defective function of natural killer cell, and massive infiltration of several organs by activated lymphocytes and macrophages. The clinical features of the disease include fever, hepatosplenomegaly, cytopenia, and less frequently neurological abnormalities ranging from irritability and hypotonia to seizures, cranial nerve deficits and ataxia.

See also OMIM:603552

Keywords - Diseasei

Familial hemophagocytic lymphohistiocytosis

Organism-specific databases

MIMi603552. phenotype.
Orphaneti540. Familial hemophagocytic lymphohistiocytosis.
PharmGKBiPA36229.

Polymorphism and mutation databases

BioMutaiSTX11.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 287287Syntaxin-11PRO_0000210221Add
BLAST

Proteomic databases

MaxQBiO75558.
PaxDbiO75558.
PRIDEiO75558.

2D gel databases

OGPiO75558.

PTM databases

PhosphoSiteiO75558.

Expressioni

Gene expression databases

BgeeiO75558.
CleanExiHS_STX11.
GenevisibleiO75558. HS.

Organism-specific databases

HPAiHPA007992.

Interactioni

Subunit structurei

Interacts with the SNARE proteins SNAP-23 and VAMP.

Binary interactionsi

WithEntry#Exp.IntActNotes
A8KAD63EBI-714135,EBI-10174974
AESQ081173EBI-714135,EBI-717810
BLOC1S6Q9UL453EBI-714135,EBI-465781
BYSLQ138955EBI-714135,EBI-358049
C1orf109Q9NX043EBI-714135,EBI-8643161
CARD9Q9H2573EBI-714135,EBI-751319
CCBE1Q6UXH83EBI-714135,EBI-3923278
CCDC184Q52MB23EBI-714135,EBI-10179526
CDCA7LQ96GN53EBI-714135,EBI-5278764
EIF1ADQ8N9N83EBI-714135,EBI-750700
FAM110AQ9BQ893EBI-714135,EBI-1752811
FAM161AQ3B8203EBI-714135,EBI-719941
FAM74A6Q5TZK33EBI-714135,EBI-10247271
FAM90A1Q86YD73EBI-714135,EBI-6658203
FARS2O953633EBI-714135,EBI-2513774
GOLGA8DPQ0D2H93EBI-714135,EBI-10181276
GOLGA8GQ08AF83EBI-714135,EBI-10181260
HAUS1Q96CS23EBI-714135,EBI-2514791
IKZF3Q9UKT93EBI-714135,EBI-747204
KAT5Q929933EBI-714135,EBI-399080
KCTD9Q7L2733EBI-714135,EBI-4397613
KLC3Q6P5973EBI-714135,EBI-1643885
LENG1Q96BZ83EBI-714135,EBI-726510
LONRF1Q17RB83EBI-714135,EBI-2341787
MBIPQ9NS73-53EBI-714135,EBI-10182361
MEOX2A4D1273EBI-714135,EBI-10172134
MFAP1P550813EBI-714135,EBI-1048159
MID2Q9UJV3-23EBI-714135,EBI-10172526
NDC80O147773EBI-714135,EBI-715849
PPP1R18Q6NYC83EBI-714135,EBI-2557469
PRKAB2O437413EBI-714135,EBI-1053424
PRPF31F1T0A53EBI-714135,EBI-10177194
RUNX1T1Q06455-43EBI-714135,EBI-10224192
SH2D4AQ9H7883EBI-714135,EBI-747035
SMARCE1Q969G33EBI-714135,EBI-455078
SNAP23A8K2873EBI-714135,EBI-10188497
SNAP23O001615EBI-714135,EBI-745000
STXBP1P617643EBI-714135,EBI-960169
TCF4P158843EBI-714135,EBI-533224
USHBP1Q8N6Y03EBI-714135,EBI-739895
VPS52Q8N1B43EBI-714135,EBI-2799833
WDYHV1Q96HA83EBI-714135,EBI-741158
ZCCHC10Q8TBK64EBI-714135,EBI-597063
ZNF417Q8TAU33EBI-714135,EBI-740727
ZNF587Q96SQ53EBI-714135,EBI-6427977

Protein-protein interaction databases

BioGridi114224. 64 interactions.
IntActiO75558. 59 interactions.
MINTiMINT-1398569.
STRINGi9606.ENSP00000356540.

Structurei

3D structure databases

ProteinModelPortaliO75558.
SMRiO75558. Positions 38-259.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini204 – 26663t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili41 – 7131Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the syntaxin family.Curated
Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG306476.
GeneTreeiENSGT00760000119200.
HOGENOMiHOG000286023.
HOVERGENiHBG099780.
InParanoidiO75558.
KOiK08487.
OMAiPHEDIVF.
OrthoDBiEOG7X9G7R.
PhylomeDBiO75558.
TreeFamiTF313763.

Family and domain databases

InterProiIPR028672. STX11.
IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PANTHERiPTHR19957:SF30. PTHR19957:SF30. 1 hit.
PfamiPF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view]
SMARTiSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O75558-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDRLAELLD LSKQYDQQFP DGDDEFDSPH EDIVFETDHI LESLYRDIRD
60 70 80 90 100
IQDENQLLVA DVKRLGKQNA RFLTSMRRLS SIKRDTNSIA KAIKARGEVI
110 120 130 140 150
HCKLRAMKEL SEAAEAQHGP HSAVARISRA QYNALTLTFQ RAMHDYNQAE
160 170 180 190 200
MKQRDNCKIR IQRQLEIMGK EVSGDQIEDM FEQGKWDVFS ENLLADVKGA
210 220 230 240 250
RAALNEIESR HRELLRLESR IRDVHELFLQ MAVLVEKQAD TLNVIELNVQ
260 270 280
KTVDYTGQAK AQVRKAVQYE EKNPCRTLCC FCCPCLK
Length:287
Mass (Da):33,196
Last modified:November 1, 1998 - v1
Checksum:i18E8B43BA987D891
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti61 – 611D → N in AAD02107 (PubMed:9571206).Curated
Sequence conflicti93 – 942IK → FR in AAC24031 (PubMed:9553086).Curated
Sequence conflicti96 – 972RG → PP in AAD02107 (PubMed:9571206).Curated
Sequence conflicti103 – 1042KL → NV in AAD02107 (PubMed:9571206).Curated
Sequence conflicti121 – 1266HSAVAR → ALGSGG in AAD02107 (PubMed:9571206).Curated
Sequence conflicti200 – 22021ARAAL…RLESR → RGPPTTRSRAATANCCAWRA A in AAC24031 (PubMed:9553086).CuratedAdd
BLAST
Sequence conflicti200 – 2001A → V in AAD02107 (PubMed:9571206).Curated
Sequence conflicti215 – 2151L → V in AAD02107 (PubMed:9571206).Curated
Sequence conflicti220 – 2201R → A in AAD02107 (PubMed:9571206).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti31 – 311E → Q.
Corresponds to variant rs1802414 [ dbSNP | Ensembl ].
VAR_011995
Natural varianti49 – 491R → Q.
Corresponds to variant rs17073498 [ dbSNP | Ensembl ].
VAR_029769
Natural varianti204 – 2041L → H.
Corresponds to variant rs1133248 [ dbSNP | Ensembl ].
VAR_011996
Natural varianti277 – 2771T → A.
Corresponds to variant rs9496891 [ dbSNP | Ensembl ].
VAR_029770

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038898 mRNA. Translation: AAD02107.1.
AF044309 mRNA. Translation: AAC24031.1.
AF071504 mRNA. Translation: AAC24004.1.
AL135917 Genomic DNA. Translation: CAI22980.1.
CH471051 Genomic DNA. Translation: EAW47849.1.
CH471051 Genomic DNA. Translation: EAW47850.1.
BC033519 mRNA. Translation: AAH33519.1.
CCDSiCCDS5205.1.
PIRiJE0094.
RefSeqiNP_003755.2. NM_003764.3.
UniGeneiHs.118958.

Genome annotation databases

EnsembliENST00000367568; ENSP00000356540; ENSG00000135604.
GeneIDi8676.
KEGGihsa:8676.
UCSCiuc003qks.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

STX11base

STX11 mutation db

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038898 mRNA. Translation: AAD02107.1.
AF044309 mRNA. Translation: AAC24031.1.
AF071504 mRNA. Translation: AAC24004.1.
AL135917 Genomic DNA. Translation: CAI22980.1.
CH471051 Genomic DNA. Translation: EAW47849.1.
CH471051 Genomic DNA. Translation: EAW47850.1.
BC033519 mRNA. Translation: AAH33519.1.
CCDSiCCDS5205.1.
PIRiJE0094.
RefSeqiNP_003755.2. NM_003764.3.
UniGeneiHs.118958.

3D structure databases

ProteinModelPortaliO75558.
SMRiO75558. Positions 38-259.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114224. 64 interactions.
IntActiO75558. 59 interactions.
MINTiMINT-1398569.
STRINGi9606.ENSP00000356540.

PTM databases

PhosphoSiteiO75558.

Polymorphism and mutation databases

BioMutaiSTX11.

2D gel databases

OGPiO75558.

Proteomic databases

MaxQBiO75558.
PaxDbiO75558.
PRIDEiO75558.

Protocols and materials databases

DNASUi8676.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367568; ENSP00000356540; ENSG00000135604.
GeneIDi8676.
KEGGihsa:8676.
UCSCiuc003qks.4. human.

Organism-specific databases

CTDi8676.
GeneCardsiGC06P144513.
GeneReviewsiSTX11.
HGNCiHGNC:11429. STX11.
HPAiHPA007992.
MIMi603552. phenotype.
605014. gene.
neXtProtiNX_O75558.
Orphaneti540. Familial hemophagocytic lymphohistiocytosis.
PharmGKBiPA36229.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG306476.
GeneTreeiENSGT00760000119200.
HOGENOMiHOG000286023.
HOVERGENiHBG099780.
InParanoidiO75558.
KOiK08487.
OMAiPHEDIVF.
OrthoDBiEOG7X9G7R.
PhylomeDBiO75558.
TreeFamiTF313763.

Miscellaneous databases

ChiTaRSiSTX11. human.
GeneWikiiSTX11.
GenomeRNAii8676.
NextBioi32547.
PROiO75558.
SOURCEiSearch...

Gene expression databases

BgeeiO75558.
CleanExiHS_STX11.
GenevisibleiO75558. HS.

Family and domain databases

InterProiIPR028672. STX11.
IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PANTHERiPTHR19957:SF30. PTHR19957:SF30. 1 hit.
PfamiPF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view]
SMARTiSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Syntaxin 11: a member of the syntaxin family without a carboxyl terminal transmembrane domain."
    Tang B.L., Low D.Y.H., Hong W.
    Biochem. Biophys. Res. Commun. 245:627-632(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Seven novel mammalian SNARE proteins localize to distinct membrane compartments."
    Advani R.J., Bae H.-R., Bock J.B., Chao D.S., Doung Y.-C., Prekeris R., Yoo J.-S., Scheller R.H.
    J. Biol. Chem. 273:10317-10324(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Syntaxin 11 is associated with SNAP-23 on late endosomes and the trans-Golgi network."
    Valdez A.C., Cabaniols J.-P., Brown M.J., Roche P.A.
    J. Cell Sci. 112:845-854(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  7. "Linkage of familial hemophagocytic lymphohistiocytosis (FHL) type-4 to chromosome 6q24 and identification of mutations in syntaxin 11."
    zur Stadt U., Schmidt S., Kasper B., Beutel K., Diler A.S., Henter J.-I., Kabisch H., Schneppenheim R., Nuernberg P., Janka G., Hennies H.C.
    Hum. Mol. Genet. 14:827-834(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN FHL4.

Entry informationi

Entry nameiSTX11_HUMAN
AccessioniPrimary (citable) accession number: O75558
Secondary accession number(s): E1P598
, O75378, O95148, Q5TCL6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: June 24, 2015
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.