ID   SG2A1_HUMAN             Reviewed;          95 AA.
AC   O75556;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   24-JAN-2024, entry version 168.
DE   RecName: Full=Mammaglobin-B;
DE   AltName: Full=Lacryglobin;
DE   AltName: Full=Lipophilin-C;
DE   AltName: Full=Mammaglobin-2;
DE   AltName: Full=Secretoglobin family 2A member 1;
DE   Flags: Precursor;
GN   Name=SCGB2A1; Synonyms=LIPHC, MGB2, UGB3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9806831; DOI=10.1006/geno.1998.5539;
RA   Becker R.M., Darrow C., Zimonjic D.B., Popescu N.C., Watson M.A.,
RA   Fleming T.P.;
RT   "Identification of mammaglobin B, a novel member of the uteroglobin gene
RT   family.";
RL   Genomics 54:70-78(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10066439; DOI=10.1006/bbrc.1999.0274;
RA   Zhao C., Nguyen T., Yusifov T., Glasgow B.J., Lehrer R.I.;
RT   "Lipophilins: human peptides homologous to rat prostatein.";
RL   Biochem. Biophys. Res. Commun. 256:147-155(1999).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Thyroid;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   PROTEIN SEQUENCE OF 19-85.
RC   TISSUE=Tear;
RX   PubMed=9504814; DOI=10.1002/elps.1150181516;
RA   Molloy M.P., Bolis S., Herbert B.R., Ou K., Tyler M.I., van Dyk D.D.,
RA   Willcox M.D., Gooley A.A., Williams K.L., Morris C.A., Walsh B.J.;
RT   "Establishment of the human reflex tear two-dimensional polyacrylamide gel
RT   electrophoresis reference map: new proteins of potential diagnostic
RT   value.";
RL   Electrophoresis 18:2811-2815(1997).
RN   [5]
RP   PROTEIN SEQUENCE OF 19-46 AND 60-78, AND MASS SPECTROMETRY.
RC   TISSUE=Tear;
RX   PubMed=9720917; DOI=10.1016/s0014-5793(98)00852-7;
RA   Lehrer R.I., Xu G., Abduragimov A., Dinh N.N., Qu X.-D., Martin D.,
RA   Glasgow B.J.;
RT   "Lipophilin, a novel heterodimeric protein of human tears.";
RL   FEBS Lett. 432:163-167(1998).
RN   [6]
RP   PROTEIN SEQUENCE OF 19-46 AND 84-95, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY.
RC   TISSUE=Tear;
RX   PubMed=25946035; DOI=10.1021/acs.jproteome.5b00179;
RA   Azkargorta M., Soria J., Ojeda C., Guzman F., Acera A., Iloro I.,
RA   Suarez T., Elortza F.;
RT   "Human basal tear peptidome characterization by CID, HCD, and ETD followed
RT   by in silico and in vitro analyses for antimicrobial peptide
RT   identification.";
RL   J. Proteome Res. 14:2649-2658(2015).
RN   [7]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA   Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA   Elledge S.J., Gygi S.P.;
RT   "A quantitative atlas of mitotic phosphorylation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
CC   -!- FUNCTION: May bind androgens and other steroids, may also bind
CC       estramustine, a chemotherapeutic agent used for prostate cancer. May be
CC       under transcriptional regulation of steroid hormones.
CC   -!- SUBUNIT: Heterodimer of a lipophilin A and a lipophilin C (mammaglobin
CC       B) monomer associated head to head.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in thymus, trachea, kidney, steroid
CC       responsive tissues (prostate, testis, uterus, breast and ovary) and
CC       salivary gland.
CC   -!- MASS SPECTROMETRY: Mass=8854.94; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:9720917};
CC   -!- SIMILARITY: Belongs to the secretoglobin family. Lipophilin subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AF071219; AAC79996.1; -; mRNA.
DR   EMBL; AJ224173; CAA11865.1; -; mRNA.
DR   EMBL; BC062218; AAH62218.1; -; mRNA.
DR   CCDS; CCDS8016.1; -.
DR   RefSeq; NP_002398.1; NM_002407.2.
DR   AlphaFoldDB; O75556; -.
DR   SMR; O75556; -.
DR   BioGRID; 110402; 146.
DR   IntAct; O75556; 18.
DR   MINT; O75556; -.
DR   STRING; 9606.ENSP00000244930; -.
DR   GlyConnect; 1487; 2 N-Linked glycans (1 site).
DR   GlyCosmos; O75556; 1 site, 2 glycans.
DR   GlyGen; O75556; 1 site, 2 N-linked glycans (1 site).
DR   iPTMnet; O75556; -.
DR   PhosphoSitePlus; O75556; -.
DR   BioMuta; SCGB2A1; -.
DR   CPTAC; CPTAC-1507; -.
DR   MassIVE; O75556; -.
DR   PaxDb; 9606-ENSP00000244930; -.
DR   PeptideAtlas; O75556; -.
DR   ProteomicsDB; 50084; -.
DR   Pumba; O75556; -.
DR   Antibodypedia; 28416; 231 antibodies from 31 providers.
DR   DNASU; 4246; -.
DR   Ensembl; ENST00000244930.6; ENSP00000244930.4; ENSG00000124939.6.
DR   GeneID; 4246; -.
DR   KEGG; hsa:4246; -.
DR   MANE-Select; ENST00000244930.6; ENSP00000244930.4; NM_002407.3; NP_002398.1.
DR   UCSC; uc001nta.2; human.
DR   AGR; HGNC:7051; -.
DR   CTD; 4246; -.
DR   DisGeNET; 4246; -.
DR   GeneCards; SCGB2A1; -.
DR   HGNC; HGNC:7051; SCGB2A1.
DR   HPA; ENSG00000124939; Group enriched (cervix, epididymis).
DR   MIM; 604398; gene.
DR   neXtProt; NX_O75556; -.
DR   OpenTargets; ENSG00000124939; -.
DR   PharmGKB; PA34992; -.
DR   VEuPathDB; HostDB:ENSG00000124939; -.
DR   eggNOG; ENOG502TE00; Eukaryota.
DR   GeneTree; ENSGT00390000013802; -.
DR   HOGENOM; CLU_161063_0_0_1; -.
DR   InParanoid; O75556; -.
DR   OMA; CKLLEDM; -.
DR   OrthoDB; 5266337at2759; -.
DR   PhylomeDB; O75556; -.
DR   TreeFam; TF338521; -.
DR   PathwayCommons; O75556; -.
DR   SignaLink; O75556; -.
DR   BioGRID-ORCS; 4246; 18 hits in 1111 CRISPR screens.
DR   ChiTaRS; SCGB2A1; human.
DR   GeneWiki; Mammaglobin-B; -.
DR   GenomeRNAi; 4246; -.
DR   Pharos; O75556; Tbio.
DR   PRO; PR:O75556; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; O75556; Protein.
DR   Bgee; ENSG00000124939; Expressed in corpus epididymis and 110 other cell types or tissues.
DR   GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
DR   GO; GO:0030521; P:androgen receptor signaling pathway; IDA:UniProtKB.
DR   CDD; cd00633; Secretoglobin; 1.
DR   InterPro; IPR016126; Secretoglobin.
DR   InterPro; IPR035960; Secretoglobin_sf.
DR   PANTHER; PTHR14037:SF4; MAMMAGLOBIN-B; 1.
DR   PANTHER; PTHR14037; MAMMAGLOBIN-RELATED; 1.
DR   Pfam; PF01099; Uteroglobin; 1.
DR   SUPFAM; SSF48201; Uteroglobin-like; 1.
DR   PROSITE; PS51311; SCGB; 1.
DR   Genevisible; O75556; HS.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Glycoprotein; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000269|PubMed:25946035,
FT                   ECO:0000269|PubMed:9504814, ECO:0000269|PubMed:9720917"
FT   CHAIN           19..95
FT                   /note="Mammaglobin-B"
FT                   /id="PRO_0000036373"
FT   CARBOHYD        68
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   95 AA;  10884 MW;  0719738289F89F8D CRC64;
     MKLLMVLMLA ALLLHCYADS GCKLLEDMVE KTINSDISIP EYKELLQEFI DSDAAAEAMG
     KFKQCFLNQS HRTLKNFGLM MHTVYDSIWC NMKSN
//