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O75556

- SG2A1_HUMAN

UniProt

O75556 - SG2A1_HUMAN

Protein

Mammaglobin-B

Gene

SCGB2A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of steroid hormones.

    GO - Molecular functioni

    1. protein heterodimerization activity Source: UniProt

    GO - Biological processi

    1. androgen receptor signaling pathway Source: UniProt

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mammaglobin-B
    Alternative name(s):
    Lacryglobin
    Lipophilin-C
    Mammaglobin-2
    Secretoglobin family 2A member 1
    Gene namesi
    Name:SCGB2A1
    Synonyms:LIPHC, MGB2, UGB3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:7051. SCGB2A1.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProt

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34992.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 18182 PublicationsAdd
    BLAST
    Chaini19 – 9577Mammaglobin-BPRO_0000036373Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi68 – 681N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiO75556.
    PRIDEiO75556.

    PTM databases

    PhosphoSiteiO75556.

    Expressioni

    Tissue specificityi

    Expressed in thymus, trachea, kidney, steroid responsive tissues (prostate, testis, uterus, breast and ovary) and salivary gland.

    Gene expression databases

    BgeeiO75556.
    CleanExiHS_SCGB2A1.
    GenevestigatoriO75556.

    Organism-specific databases

    HPAiHPA034584.

    Interactioni

    Subunit structurei

    Heterodimer of a lipophilin A and a lipophilin C (mammaglobin B) monomer associated head to head.

    Protein-protein interaction databases

    BioGridi110402. 2 interactions.
    STRINGi9606.ENSP00000244930.

    Structurei

    3D structure databases

    ProteinModelPortaliO75556.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG83953.
    HOGENOMiHOG000294150.
    HOVERGENiHBG005021.
    InParanoidiO75556.
    OrthoDBiEOG79W97Q.
    PhylomeDBiO75556.
    TreeFamiTF338521.

    Family and domain databases

    InterProiIPR016126. Secretoglobin.
    [Graphical view]
    PfamiPF01099. Uteroglobin. 1 hit.
    [Graphical view]
    SUPFAMiSSF48201. SSF48201. 1 hit.
    PROSITEiPS51311. SCGB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O75556-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLLMVLMLA ALLLHCYADS GCKLLEDMVE KTINSDISIP EYKELLQEFI   50
    DSDAAAEAMG KFKQCFLNQS HRTLKNFGLM MHTVYDSIWC NMKSN 95
    Length:95
    Mass (Da):10,884
    Last modified:November 1, 1998 - v1
    Checksum:i0719738289F89F8D
    GO

    Mass spectrometryi

    Molecular mass is 8854.94 Da from positions 19 - 95. Determined by ESI. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF071219 mRNA. Translation: AAC79996.1.
    AJ224173 mRNA. Translation: CAA11865.1.
    BC062218 mRNA. Translation: AAH62218.1.
    CCDSiCCDS8016.1.
    RefSeqiNP_002398.1. NM_002407.2.
    UniGeneiHs.97644.

    Genome annotation databases

    EnsembliENST00000244930; ENSP00000244930; ENSG00000124939.
    GeneIDi4246.
    KEGGihsa:4246.
    UCSCiuc001nta.2. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF071219 mRNA. Translation: AAC79996.1 .
    AJ224173 mRNA. Translation: CAA11865.1 .
    BC062218 mRNA. Translation: AAH62218.1 .
    CCDSi CCDS8016.1.
    RefSeqi NP_002398.1. NM_002407.2.
    UniGenei Hs.97644.

    3D structure databases

    ProteinModelPortali O75556.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110402. 2 interactions.
    STRINGi 9606.ENSP00000244930.

    PTM databases

    PhosphoSitei O75556.

    Proteomic databases

    PaxDbi O75556.
    PRIDEi O75556.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000244930 ; ENSP00000244930 ; ENSG00000124939 .
    GeneIDi 4246.
    KEGGi hsa:4246.
    UCSCi uc001nta.2. human.

    Organism-specific databases

    CTDi 4246.
    GeneCardsi GC11P061976.
    HGNCi HGNC:7051. SCGB2A1.
    HPAi HPA034584.
    MIMi 604398. gene.
    neXtProti NX_O75556.
    PharmGKBi PA34992.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG83953.
    HOGENOMi HOG000294150.
    HOVERGENi HBG005021.
    InParanoidi O75556.
    OrthoDBi EOG79W97Q.
    PhylomeDBi O75556.
    TreeFami TF338521.

    Miscellaneous databases

    GeneWikii Mammaglobin-B.
    GenomeRNAii 4246.
    NextBioi 16737.
    PROi O75556.
    SOURCEi Search...

    Gene expression databases

    Bgeei O75556.
    CleanExi HS_SCGB2A1.
    Genevestigatori O75556.

    Family and domain databases

    InterProi IPR016126. Secretoglobin.
    [Graphical view ]
    Pfami PF01099. Uteroglobin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48201. SSF48201. 1 hit.
    PROSITEi PS51311. SCGB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of mammaglobin B, a novel member of the uteroglobin gene family."
      Becker R.M., Darrow C., Zimonjic D.B., Popescu N.C., Watson M.A., Fleming T.P.
      Genomics 54:70-78(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Thyroid.
    4. "Establishment of the human reflex tear two-dimensional polyacrylamide gel electrophoresis reference map: new proteins of potential diagnostic value."
      Molloy M.P., Bolis S., Herbert B.R., Ou K., Tyler M.I., van Dyk D.D., Willcox M.D., Gooley A.A., Williams K.L., Morris C.A., Walsh B.J.
      Electrophoresis 18:2811-2815(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 19-85.
      Tissue: Tear.
    5. "Lipophilin, a novel heterodimeric protein of human tears."
      Lehrer R.I., Xu G., Abduragimov A., Dinh N.N., Qu X.-D., Martin D., Glasgow B.J.
      FEBS Lett. 432:163-167(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 19-46 AND 60-78, MASS SPECTROMETRY.
      Tissue: Tear.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiSG2A1_HUMAN
    AccessioniPrimary (citable) accession number: O75556
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3