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Protein

Mammaglobin-B

Gene

SCGB2A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of steroid hormones.

GO - Molecular functioni

  • protein heterodimerization activity Source: UniProtKB

GO - Biological processi

  • androgen receptor signaling pathway Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000124939-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Mammaglobin-B
Alternative name(s):
Lacryglobin
Lipophilin-C
Mammaglobin-2
Secretoglobin family 2A member 1
Gene namesi
Name:SCGB2A1
Synonyms:LIPHC, MGB2, UGB3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:7051. SCGB2A1.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi4246.
OpenTargetsiENSG00000124939.
PharmGKBiPA34992.

Polymorphism and mutation databases

BioMutaiSCGB2A1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 183 PublicationsAdd BLAST18
ChainiPRO_000003637319 – 95Mammaglobin-BAdd BLAST77

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi68N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO75556.
PeptideAtlasiO75556.
PRIDEiO75556.

PTM databases

iPTMnetiO75556.
PhosphoSitePlusiO75556.

Expressioni

Tissue specificityi

Expressed in thymus, trachea, kidney, steroid responsive tissues (prostate, testis, uterus, breast and ovary) and salivary gland.

Gene expression databases

BgeeiENSG00000124939.
CleanExiHS_SCGB2A1.
GenevisibleiO75556. HS.

Organism-specific databases

HPAiHPA034584.

Interactioni

Subunit structurei

Heterodimer of a lipophilin A and a lipophilin C (mammaglobin B) monomer associated head to head.

GO - Molecular functioni

  • protein heterodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi110402. 12 interactors.
IntActiO75556. 6 interactors.
STRINGi9606.ENSP00000244930.

Structurei

3D structure databases

ProteinModelPortaliO75556.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JEU0. Eukaryota.
ENOG4111A32. LUCA.
GeneTreeiENSGT00390000013802.
HOGENOMiHOG000294150.
HOVERGENiHBG005021.
InParanoidiO75556.
OMAiLHCYADS.
OrthoDBiEOG091G16OV.
PhylomeDBiO75556.
TreeFamiTF338521.

Family and domain databases

CDDicd00633. Secretoglobin. 1 hit.
InterProiIPR016126. Secretoglobin.
[Graphical view]
PfamiPF01099. Uteroglobin. 1 hit.
[Graphical view]
SUPFAMiSSF48201. SSF48201. 1 hit.
PROSITEiPS51311. SCGB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O75556-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLLMVLMLA ALLLHCYADS GCKLLEDMVE KTINSDISIP EYKELLQEFI
60 70 80 90
DSDAAAEAMG KFKQCFLNQS HRTLKNFGLM MHTVYDSIWC NMKSN
Length:95
Mass (Da):10,884
Last modified:November 1, 1998 - v1
Checksum:i0719738289F89F8D
GO

Mass spectrometryi

Molecular mass is 8854.94 Da from positions 19 - 95. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071219 mRNA. Translation: AAC79996.1.
AJ224173 mRNA. Translation: CAA11865.1.
BC062218 mRNA. Translation: AAH62218.1.
CCDSiCCDS8016.1.
RefSeqiNP_002398.1. NM_002407.2.
UniGeneiHs.97644.

Genome annotation databases

EnsembliENST00000244930; ENSP00000244930; ENSG00000124939.
GeneIDi4246.
KEGGihsa:4246.
UCSCiuc001nta.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071219 mRNA. Translation: AAC79996.1.
AJ224173 mRNA. Translation: CAA11865.1.
BC062218 mRNA. Translation: AAH62218.1.
CCDSiCCDS8016.1.
RefSeqiNP_002398.1. NM_002407.2.
UniGeneiHs.97644.

3D structure databases

ProteinModelPortaliO75556.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110402. 12 interactors.
IntActiO75556. 6 interactors.
STRINGi9606.ENSP00000244930.

PTM databases

iPTMnetiO75556.
PhosphoSitePlusiO75556.

Polymorphism and mutation databases

BioMutaiSCGB2A1.

Proteomic databases

PaxDbiO75556.
PeptideAtlasiO75556.
PRIDEiO75556.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000244930; ENSP00000244930; ENSG00000124939.
GeneIDi4246.
KEGGihsa:4246.
UCSCiuc001nta.2. human.

Organism-specific databases

CTDi4246.
DisGeNETi4246.
GeneCardsiSCGB2A1.
HGNCiHGNC:7051. SCGB2A1.
HPAiHPA034584.
MIMi604398. gene.
neXtProtiNX_O75556.
OpenTargetsiENSG00000124939.
PharmGKBiPA34992.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JEU0. Eukaryota.
ENOG4111A32. LUCA.
GeneTreeiENSGT00390000013802.
HOGENOMiHOG000294150.
HOVERGENiHBG005021.
InParanoidiO75556.
OMAiLHCYADS.
OrthoDBiEOG091G16OV.
PhylomeDBiO75556.
TreeFamiTF338521.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000124939-MONOMER.

Miscellaneous databases

GeneWikiiMammaglobin-B.
GenomeRNAii4246.
PROiO75556.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000124939.
CleanExiHS_SCGB2A1.
GenevisibleiO75556. HS.

Family and domain databases

CDDicd00633. Secretoglobin. 1 hit.
InterProiIPR016126. Secretoglobin.
[Graphical view]
PfamiPF01099. Uteroglobin. 1 hit.
[Graphical view]
SUPFAMiSSF48201. SSF48201. 1 hit.
PROSITEiPS51311. SCGB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSG2A1_HUMAN
AccessioniPrimary (citable) accession number: O75556
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.