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O75556

- SG2A1_HUMAN

UniProt

O75556 - SG2A1_HUMAN

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Protein

Mammaglobin-B

Gene

SCGB2A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of steroid hormones.

GO - Molecular functioni

  1. protein heterodimerization activity Source: UniProt

GO - Biological processi

  1. androgen receptor signaling pathway Source: UniProt
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Mammaglobin-B
Alternative name(s):
Lacryglobin
Lipophilin-C
Mammaglobin-2
Secretoglobin family 2A member 1
Gene namesi
Name:SCGB2A1
Synonyms:LIPHC, MGB2, UGB3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:7051. SCGB2A1.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProt
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34992.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 18182 PublicationsAdd
BLAST
Chaini19 – 9577Mammaglobin-BPRO_0000036373Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi68 – 681N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO75556.
PRIDEiO75556.

PTM databases

PhosphoSiteiO75556.

Expressioni

Tissue specificityi

Expressed in thymus, trachea, kidney, steroid responsive tissues (prostate, testis, uterus, breast and ovary) and salivary gland.

Gene expression databases

BgeeiO75556.
CleanExiHS_SCGB2A1.
GenevestigatoriO75556.

Organism-specific databases

HPAiHPA034584.

Interactioni

Subunit structurei

Heterodimer of a lipophilin A and a lipophilin C (mammaglobin B) monomer associated head to head.

Protein-protein interaction databases

BioGridi110402. 8 interactions.
STRINGi9606.ENSP00000244930.

Structurei

3D structure databases

ProteinModelPortaliO75556.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG83953.
GeneTreeiENSGT00390000013802.
HOGENOMiHOG000294150.
HOVERGENiHBG005021.
InParanoidiO75556.
OrthoDBiEOG79W97Q.
PhylomeDBiO75556.
TreeFamiTF338521.

Family and domain databases

InterProiIPR016126. Secretoglobin.
[Graphical view]
PfamiPF01099. Uteroglobin. 1 hit.
[Graphical view]
SUPFAMiSSF48201. SSF48201. 1 hit.
PROSITEiPS51311. SCGB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O75556-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLLMVLMLA ALLLHCYADS GCKLLEDMVE KTINSDISIP EYKELLQEFI
60 70 80 90
DSDAAAEAMG KFKQCFLNQS HRTLKNFGLM MHTVYDSIWC NMKSN
Length:95
Mass (Da):10,884
Last modified:November 1, 1998 - v1
Checksum:i0719738289F89F8D
GO

Mass spectrometryi

Molecular mass is 8854.94 Da from positions 19 - 95. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF071219 mRNA. Translation: AAC79996.1.
AJ224173 mRNA. Translation: CAA11865.1.
BC062218 mRNA. Translation: AAH62218.1.
CCDSiCCDS8016.1.
RefSeqiNP_002398.1. NM_002407.2.
UniGeneiHs.97644.

Genome annotation databases

EnsembliENST00000244930; ENSP00000244930; ENSG00000124939.
GeneIDi4246.
KEGGihsa:4246.
UCSCiuc001nta.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF071219 mRNA. Translation: AAC79996.1 .
AJ224173 mRNA. Translation: CAA11865.1 .
BC062218 mRNA. Translation: AAH62218.1 .
CCDSi CCDS8016.1.
RefSeqi NP_002398.1. NM_002407.2.
UniGenei Hs.97644.

3D structure databases

ProteinModelPortali O75556.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110402. 8 interactions.
STRINGi 9606.ENSP00000244930.

PTM databases

PhosphoSitei O75556.

Proteomic databases

PaxDbi O75556.
PRIDEi O75556.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000244930 ; ENSP00000244930 ; ENSG00000124939 .
GeneIDi 4246.
KEGGi hsa:4246.
UCSCi uc001nta.2. human.

Organism-specific databases

CTDi 4246.
GeneCardsi GC11P061976.
HGNCi HGNC:7051. SCGB2A1.
HPAi HPA034584.
MIMi 604398. gene.
neXtProti NX_O75556.
PharmGKBi PA34992.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG83953.
GeneTreei ENSGT00390000013802.
HOGENOMi HOG000294150.
HOVERGENi HBG005021.
InParanoidi O75556.
OrthoDBi EOG79W97Q.
PhylomeDBi O75556.
TreeFami TF338521.

Miscellaneous databases

GeneWikii Mammaglobin-B.
GenomeRNAii 4246.
NextBioi 16737.
PROi O75556.
SOURCEi Search...

Gene expression databases

Bgeei O75556.
CleanExi HS_SCGB2A1.
Genevestigatori O75556.

Family and domain databases

InterProi IPR016126. Secretoglobin.
[Graphical view ]
Pfami PF01099. Uteroglobin. 1 hit.
[Graphical view ]
SUPFAMi SSF48201. SSF48201. 1 hit.
PROSITEi PS51311. SCGB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of mammaglobin B, a novel member of the uteroglobin gene family."
    Becker R.M., Darrow C., Zimonjic D.B., Popescu N.C., Watson M.A., Fleming T.P.
    Genomics 54:70-78(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thyroid.
  4. "Establishment of the human reflex tear two-dimensional polyacrylamide gel electrophoresis reference map: new proteins of potential diagnostic value."
    Molloy M.P., Bolis S., Herbert B.R., Ou K., Tyler M.I., van Dyk D.D., Willcox M.D., Gooley A.A., Williams K.L., Morris C.A., Walsh B.J.
    Electrophoresis 18:2811-2815(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 19-85.
    Tissue: Tear.
  5. "Lipophilin, a novel heterodimeric protein of human tears."
    Lehrer R.I., Xu G., Abduragimov A., Dinh N.N., Qu X.-D., Martin D., Glasgow B.J.
    FEBS Lett. 432:163-167(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 19-46 AND 60-78, MASS SPECTROMETRY.
    Tissue: Tear.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiSG2A1_HUMAN
AccessioniPrimary (citable) accession number: O75556
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: October 29, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3