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O75556 (SG2A1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mammaglobin-B
Alternative name(s):
Lacryglobin
Lipophilin-C
Mammaglobin-2
Secretoglobin family 2A member 1
Gene names
Name:SCGB2A1
Synonyms:LIPHC, MGB2, UGB3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length95 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of steroid hormones.

Subunit structure

Heterodimer of a lipophilin A and a lipophilin C (mammaglobin B) monomer associated head to head.

Tissue specificity

Expressed in thymus, trachea, kidney, steroid responsive tissues (prostate, testis, uterus, breast and ovary) and salivary gland.

Sequence similarities

Belongs to the secretoglobin family. Lipophilin subfamily.

Mass spectrometry

Molecular mass is 8854.94 Da from positions 19 - 95. Determined by ESI. Ref.5

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Ref.4 Ref.5
Chain19 – 9577Mammaglobin-B
PRO_0000036373

Amino acid modifications

Glycosylation681N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
O75556 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 0719738289F89F8D

FASTA9510,884
        10         20         30         40         50         60 
MKLLMVLMLA ALLLHCYADS GCKLLEDMVE KTINSDISIP EYKELLQEFI DSDAAAEAMG 

        70         80         90 
KFKQCFLNQS HRTLKNFGLM MHTVYDSIWC NMKSN 

« Hide

References

« Hide 'large scale' references
[1]"Identification of mammaglobin B, a novel member of the uteroglobin gene family."
Becker R.M., Darrow C., Zimonjic D.B., Popescu N.C., Watson M.A., Fleming T.P.
Genomics 54:70-78(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Lipophilins: human peptides homologous to rat prostatein."
Zhao C., Nguyen T., Yusifov T., Glasgow B.J., Lehrer R.I.
Biochem. Biophys. Res. Commun. 256:147-155(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Thyroid.
[4]"Establishment of the human reflex tear two-dimensional polyacrylamide gel electrophoresis reference map: new proteins of potential diagnostic value."
Molloy M.P., Bolis S., Herbert B.R., Ou K., Tyler M.I., van Dyk D.D., Willcox M.D., Gooley A.A., Williams K.L., Morris C.A., Walsh B.J.
Electrophoresis 18:2811-2815(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 19-85.
Tissue: Tear.
[5]"Lipophilin, a novel heterodimeric protein of human tears."
Lehrer R.I., Xu G., Abduragimov A., Dinh N.N., Qu X.-D., Martin D., Glasgow B.J.
FEBS Lett. 432:163-167(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 19-46 AND 60-78, MASS SPECTROMETRY.
Tissue: Tear.
[6]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF071219 mRNA. Translation: AAC79996.1.
AJ224173 mRNA. Translation: CAA11865.1.
BC062218 mRNA. Translation: AAH62218.1.
CCDSCCDS8016.1.
RefSeqNP_002398.1. NM_002407.2.
UniGeneHs.97644.

3D structure databases

ProteinModelPortalO75556.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110402. 2 interactions.
STRING9606.ENSP00000244930.

PTM databases

PhosphoSiteO75556.

Proteomic databases

PaxDbO75556.
PRIDEO75556.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000244930; ENSP00000244930; ENSG00000124939.
GeneID4246.
KEGGhsa:4246.
UCSCuc001nta.2. human.

Organism-specific databases

CTD4246.
GeneCardsGC11P061976.
HGNCHGNC:7051. SCGB2A1.
HPAHPA034584.
MIM604398. gene.
neXtProtNX_O75556.
PharmGKBPA34992.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG83953.
HOGENOMHOG000294150.
HOVERGENHBG005021.
InParanoidO75556.
OrthoDBEOG79W97Q.
PhylomeDBO75556.
TreeFamTF338521.

Gene expression databases

BgeeO75556.
CleanExHS_SCGB2A1.
GenevestigatorO75556.

Family and domain databases

InterProIPR016126. Secretoglobin.
[Graphical view]
PfamPF01099. Uteroglobin. 1 hit.
[Graphical view]
SUPFAMSSF48201. SSF48201. 1 hit.
PROSITEPS51311. SCGB. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiMammaglobin-B.
GenomeRNAi4246.
NextBio16737.
PROO75556.
SOURCESearch...

Entry information

Entry nameSG2A1_HUMAN
AccessionPrimary (citable) accession number: O75556
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: July 9, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM