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O75553

- DAB1_HUMAN

UniProt

O75553 - DAB1_HUMAN

Protein

Disabled homolog 1

Gene

DAB1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 3 (26 Jun 2007)
      Previous versions | rss
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    Functioni

    Adapter molecule functioning in neural development. May regulate SIAH1 activity By similarity.By similarity

    GO - Biological processi

    1. adult walking behavior Source: Ensembl
    2. cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration Source: Ensembl
    3. cerebellum structural organization Source: Ensembl
    4. dendrite development Source: Ensembl
    5. Golgi localization Source: Ensembl
    6. lateral motor column neuron migration Source: Ensembl
    7. midgut development Source: Ensembl
    8. negative regulation of astrocyte differentiation Source: Ensembl
    9. negative regulation of axonogenesis Source: Ensembl
    10. negative regulation of cell adhesion Source: Ensembl
    11. negative regulation of JAK-STAT cascade Source: Ensembl
    12. positive regulation of neuron differentiation Source: Ensembl
    13. positive regulation of protein kinase activity Source: Ensembl
    14. radial glia guided migration of Purkinje cell Source: Ensembl
    15. response to drug Source: Ensembl
    16. small GTPase mediated signal transduction Source: Ensembl
    17. ventral spinal cord development Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Neurogenesis

    Enzyme and pathway databases

    SignaLinkiO75553.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Disabled homolog 1
    Gene namesi
    Name:DAB1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:2661. DAB1.

    Subcellular locationi

    GO - Cellular componenti

    1. apical part of cell Source: Ensembl
    2. brush border Source: Ensembl
    3. cytosol Source: Ensembl
    4. membrane Source: Ensembl
    5. neuronal cell body Source: Ensembl
    6. neuron projection Source: Ensembl
    7. perinuclear region of cytoplasm Source: Ensembl
    8. postsynaptic density Source: Ensembl

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27131.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 588588Disabled homolog 1PRO_0000079767Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei198 – 1981PhosphotyrosineBy similarity
    Modified residuei220 – 2201PhosphotyrosineBy similarity
    Modified residuei232 – 2321PhosphotyrosineBy similarity
    Modified residuei524 – 5241Phosphoserine; by CDK5By similarity

    Post-translational modificationi

    Phosphorylated on Tyr-198 and Tyr-220 upon reelin induction in embryonic neurons. Also phosphorylated on Ser-524 independently of reelin signaling.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiO75553.
    PRIDEiO75553.

    PTM databases

    PhosphoSiteiO75553.

    Expressioni

    Gene expression databases

    ArrayExpressiO75553.
    BgeeiO75553.
    GenevestigatoriO75553.

    Organism-specific databases

    HPAiCAB032329.

    Interactioni

    Subunit structurei

    Associates with the SH2 domains of SRC, FYN and ABL. Interacts (phosphorylated on tyrosine residues) with CRK and CRKL (via respective SH2 domain). Interacts with DAB2IP, SIAH1, LRP1, LRP8 and VLDLR.1 Publication

    Protein-protein interaction databases

    BioGridi107970. 17 interactions.
    IntActiO75553. 2 interactions.
    MINTiMINT-156038.

    Structurei

    3D structure databases

    ProteinModelPortaliO75553.
    SMRiO75553. Positions 23-174.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini36 – 189154PIDPROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The PID domain specifically binds to the Asn-Pro-Xaa-Tyr(P) motif found in many tyrosine-phosphorylated proteins.

    Sequence similaritiesi

    Contains 1 PID domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG313182.
    HOVERGENiHBG018945.
    InParanoidiO75553.
    OMAiFQMAQPP.
    OrthoDBiEOG7HQN7R.
    PhylomeDBiO75553.
    TreeFamiTF316724.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    InterProiIPR011993. PH_like_dom.
    IPR006020. PTB/PI_dom.
    [Graphical view]
    PfamiPF00640. PID. 1 hit.
    [Graphical view]
    SMARTiSM00462. PTB. 1 hit.
    [Graphical view]
    PROSITEiPS01179. PID. 1 hit.
    [Graphical view]

    Sequences (6)i

    Sequence statusi: Complete.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Isoform DAB588 (identifier: O75553-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSTETELQVA VKTSAKKDSR KKGQDRSEAT LIKRFKGEGV RYKAKLIGID    50
    EVSAARGDKL CQDSMMKLKG VVAGARSKGE HKQKIFLTIS FGGIKIFDEK 100
    TGALQHHHAV HEISYIAKDI TDHRAFGYVC GKEGNHRFVA IKTAQAAEPV 150
    ILDLRDLFQL IYELKQREEL EKKAQKDKQC EQAVYQTILE EDVEDPVYQY 200
    IVFEAGHEPI RDPETEENIY QVPTSQKKEG VYDVPKSQPV SNGYSFEDFE 250
    ERFAAATPNR NLPTDFDEIF EATKAVTQLE LFGDMSTPPD ITSPPTPATP 300
    GDAFIPSSSQ TLPASADVFS SVPFGTAAVP SGYVAMGAVL PSFWGQQPLV 350
    QQQMVMGAQP PVAQVMPGAQ PIAWGQPGLF PATQQPWPTV AGQFPPAAFM 400
    PTQTVMPLPA AMFQGPLTPL ATVPGTSDST RSSPQTDKPR QKMGKETFKD 450
    FQMAQPPPVP SRKPDQPSLT CTSEAFSSYF NKVGVAQDTD DCDDFDISQL 500
    NLTPVTSTTP STNSPPTPAP RQSSPSKSSA SHASDPTTDD IFEEGFESPS 550
    KSEEQEAPDG SQASSNSDPF GEPSGEPSGD NISPQAGS 588

    Note: No experimental confirmation available.

    Length:588
    Mass (Da):63,775
    Last modified:June 26, 2007 - v3
    Checksum:iDAD4024364113AC5
    GO
    Isoform DAB213 (identifier: O75553-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         200-213: YIVFEAGHEPIRDP → VISETSRGFRFKSD
         214-588: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:213
    Mass (Da):24,091
    Checksum:i9A3ADE86341D96E1
    GO
    Isoform DAB469 (identifier: O75553-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         103-221: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:469
    Mass (Da):49,856
    Checksum:i5A03F93BDB4BAF42
    GO
    Isoform DAB537 (identifier: O75553-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         185-219: Missing.
         259-274: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:537
    Mass (Da):57,720
    Checksum:i6626BD99FE7C098C
    GO
    Isoform DAB553 (identifier: O75553-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         185-219: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:553
    Mass (Da):59,612
    Checksum:i59BC5E84DEF5F583
    GO
    Isoform DAB555 (identifier: O75553-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         242-274: Missing.

    Show »
    Length:555
    Mass (Da):59,950
    Checksum:i9EB4FC3D31BBF8CB
    GO

    Sequence cautioni

    The sequence BAE06094.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti15 – 151A → T in AAI12939. (PubMed:15489334)Curated
    Sequence conflicti59 – 591K → M in AAH67447. (PubMed:15489334)Curated
    Sequence conflicti86 – 861F → L in AAF73058. 1 PublicationCurated
    Sequence conflicti295 – 2951P → S in AAH67447. (PubMed:15489334)Curated
    Sequence conflicti324 – 3241F → L in AAC70068. (PubMed:9790777)Curated
    Sequence conflicti331 – 3311S → P in AAC70068. (PubMed:9790777)Curated
    Sequence conflicti359 – 3591Q → H in AAC70068. (PubMed:9790777)Curated
    Sequence conflicti368 – 3681G → R in AAF73058. 1 PublicationCurated
    Sequence conflicti412 – 4121M → V in AAF73058. 1 PublicationCurated
    Sequence conflicti586 – 5861A → D in AAC70068. (PubMed:9790777)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti71 – 711V → I.
    Corresponds to variant rs1855377 [ dbSNP | Ensembl ].
    VAR_056857

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei103 – 221119Missing in isoform DAB469. 1 PublicationVSP_026166Add
    BLAST
    Alternative sequencei185 – 21935Missing in isoform DAB553 and isoform DAB537. 1 PublicationVSP_026167Add
    BLAST
    Alternative sequencei200 – 21314YIVFE…PIRDP → VISETSRGFRFKSD in isoform DAB213. CuratedVSP_026168Add
    BLAST
    Alternative sequencei214 – 588375Missing in isoform DAB213. CuratedVSP_026169Add
    BLAST
    Alternative sequencei242 – 27433Missing in isoform DAB555. 3 PublicationsVSP_026170Add
    BLAST
    Alternative sequencei259 – 27416Missing in isoform DAB537. 1 PublicationVSP_026171Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF071062 mRNA. Translation: AAC70068.1.
    AF263547 mRNA. Translation: AAF73058.1.
    AL139219, AL354883 Genomic DNA. Translation: CAI19217.1.
    AL139219, AL161740, AL354883 Genomic DNA. Translation: CAI19218.1.
    AL139219, AL161740, AL354883 Genomic DNA. Translation: CAI19219.1.
    AL139219, AL354883 Genomic DNA. Translation: CAI19220.1.
    AL139219, AL161740, AL354883 Genomic DNA. Translation: CAI19221.1.
    AL161740, AL139219, AL354883 Genomic DNA. Translation: CAI18815.1.
    AL161740, AL139219, AL354883 Genomic DNA. Translation: CAI18816.1.
    AL161740, AL139219, AL354883 Genomic DNA. Translation: CAI18817.1.
    AL354883, AL139219 Genomic DNA. Translation: CAI22360.1.
    AL354883, AL139219, AL161740 Genomic DNA. Translation: CAI22361.1.
    AL354883, AL139219, AL161740 Genomic DNA. Translation: CAI22362.1.
    AL354883, AL139219 Genomic DNA. Translation: CAI22363.1.
    AL354883, AL139219, AL161740 Genomic DNA. Translation: CAI22364.1.
    AK095513 mRNA. Translation: BAG53075.1.
    AB210012 mRNA. Translation: BAE06094.1. Different initiation.
    CH471059 Genomic DNA. Translation: EAX06637.1.
    BC067445 mRNA. Translation: AAH67445.1.
    BC067446 mRNA. Translation: AAH67446.1.
    BC067447 mRNA. Translation: AAH67447.1.
    BC112938 mRNA. Translation: AAI12939.1.
    CCDSiCCDS607.1. [O75553-6]
    RefSeqiNP_066566.3. NM_021080.3. [O75553-6]
    UniGeneiHs.477370.

    Genome annotation databases

    EnsembliENST00000371230; ENSP00000360274; ENSG00000173406. [O75553-2]
    ENST00000371231; ENSP00000360275; ENSG00000173406. [O75553-1]
    ENST00000371236; ENSP00000360280; ENSG00000173406. [O75553-6]
    ENST00000414851; ENSP00000387581; ENSG00000173406. [O75553-4]
    ENST00000420954; ENSP00000395296; ENSG00000173406. [O75553-5]
    GeneIDi1600.
    KEGGihsa:1600.
    UCSCiuc001cyq.1. human. [O75553-5]
    uc001cyr.1. human. [O75553-3]
    uc001cys.1. human. [O75553-6]
    uc001cyt.1. human. [O75553-1]
    uc009vzw.1. human. [O75553-4]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF071062 mRNA. Translation: AAC70068.1 .
    AF263547 mRNA. Translation: AAF73058.1 .
    AL139219 , AL354883 Genomic DNA. Translation: CAI19217.1 .
    AL139219 , AL161740 , AL354883 Genomic DNA. Translation: CAI19218.1 .
    AL139219 , AL161740 , AL354883 Genomic DNA. Translation: CAI19219.1 .
    AL139219 , AL354883 Genomic DNA. Translation: CAI19220.1 .
    AL139219 , AL161740 , AL354883 Genomic DNA. Translation: CAI19221.1 .
    AL161740 , AL139219 , AL354883 Genomic DNA. Translation: CAI18815.1 .
    AL161740 , AL139219 , AL354883 Genomic DNA. Translation: CAI18816.1 .
    AL161740 , AL139219 , AL354883 Genomic DNA. Translation: CAI18817.1 .
    AL354883 , AL139219 Genomic DNA. Translation: CAI22360.1 .
    AL354883 , AL139219 , AL161740 Genomic DNA. Translation: CAI22361.1 .
    AL354883 , AL139219 , AL161740 Genomic DNA. Translation: CAI22362.1 .
    AL354883 , AL139219 Genomic DNA. Translation: CAI22363.1 .
    AL354883 , AL139219 , AL161740 Genomic DNA. Translation: CAI22364.1 .
    AK095513 mRNA. Translation: BAG53075.1 .
    AB210012 mRNA. Translation: BAE06094.1 . Different initiation.
    CH471059 Genomic DNA. Translation: EAX06637.1 .
    BC067445 mRNA. Translation: AAH67445.1 .
    BC067446 mRNA. Translation: AAH67446.1 .
    BC067447 mRNA. Translation: AAH67447.1 .
    BC112938 mRNA. Translation: AAI12939.1 .
    CCDSi CCDS607.1. [O75553-6 ]
    RefSeqi NP_066566.3. NM_021080.3. [O75553-6 ]
    UniGenei Hs.477370.

    3D structure databases

    ProteinModelPortali O75553.
    SMRi O75553. Positions 23-174.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107970. 17 interactions.
    IntActi O75553. 2 interactions.
    MINTi MINT-156038.

    PTM databases

    PhosphoSitei O75553.

    Proteomic databases

    PaxDbi O75553.
    PRIDEi O75553.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000371230 ; ENSP00000360274 ; ENSG00000173406 . [O75553-2 ]
    ENST00000371231 ; ENSP00000360275 ; ENSG00000173406 . [O75553-1 ]
    ENST00000371236 ; ENSP00000360280 ; ENSG00000173406 . [O75553-6 ]
    ENST00000414851 ; ENSP00000387581 ; ENSG00000173406 . [O75553-4 ]
    ENST00000420954 ; ENSP00000395296 ; ENSG00000173406 . [O75553-5 ]
    GeneIDi 1600.
    KEGGi hsa:1600.
    UCSCi uc001cyq.1. human. [O75553-5 ]
    uc001cyr.1. human. [O75553-3 ]
    uc001cys.1. human. [O75553-6 ]
    uc001cyt.1. human. [O75553-1 ]
    uc009vzw.1. human. [O75553-4 ]

    Organism-specific databases

    CTDi 1600.
    GeneCardsi GC01M057460.
    HGNCi HGNC:2661. DAB1.
    HPAi CAB032329.
    MIMi 603448. gene.
    neXtProti NX_O75553.
    PharmGKBi PA27131.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG313182.
    HOVERGENi HBG018945.
    InParanoidi O75553.
    OMAi FQMAQPP.
    OrthoDBi EOG7HQN7R.
    PhylomeDBi O75553.
    TreeFami TF316724.

    Enzyme and pathway databases

    SignaLinki O75553.

    Miscellaneous databases

    ChiTaRSi DAB1. human.
    GeneWikii DAB1.
    GenomeRNAii 1600.
    NextBioi 6562.
    PROi O75553.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O75553.
    Bgeei O75553.
    Genevestigatori O75553.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    InterProi IPR011993. PH_like_dom.
    IPR006020. PTB/PI_dom.
    [Graphical view ]
    Pfami PF00640. PID. 1 hit.
    [Graphical view ]
    SMARTi SM00462. PTB. 1 hit.
    [Graphical view ]
    PROSITEi PS01179. PID. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of human DAB1 and mapping to chromosome 1p31-p32."
      Lambert de Rouvroit C., Goffinet A.M.
      Genomics 53:246-247(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM DAB555).
    2. "Aberrant disabled-1 expression in tumors."
      Fazili Z., Sun W., Xu X.-X.
      Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM DAB555).
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM DAB555).
      Tissue: Brain.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS DAB469; DAB537 AND DAB553).
    7. "Serine and threonine phosphorylation of the low density lipoprotein receptor-related protein by protein kinase Calpha regulates endocytosis and association with adaptor molecules."
      Ranganathan S., Liu C.-X., Migliorini M.M., Von Arnim C.A.F., Peltan I.D., Mikhailenko I., Hyman B.T., Strickland D.K.
      J. Biol. Chem. 279:40536-40544(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH LRP1.

    Entry informationi

    Entry nameiDAB1_HUMAN
    AccessioniPrimary (citable) accession number: O75553
    Secondary accession number(s): A4FU90
    , B3KTG3, Q4LE59, Q5T6M6, Q5T6M9, Q5T835, Q5T836, Q5T837, Q6NWS9, Q6NWT0, Q6NWT1, Q9NYA8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 11, 2002
    Last sequence update: June 26, 2007
    Last modified: October 1, 2014
    This is version 113 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3