O75553 (DAB1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Disabled homolog 1

Gene names

Name:

DAB1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	588 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Adapter molecule functioning in neural development. May regulate SIAH1 activity By similarity.
Subunit structure	Associates with the SH2 domains of SRC, FYN and ABL. Interacts (phosphorylated on tyrosine residues) with CRK and CRKL (via respective SH2 domain). Interacts with DAB2IP, SIAH1, LRP1, LRP8 and VLDLR. Ref.7
Domain	The PID domain specifically binds to the Asn-Pro-Xaa-Tyr(P) motif found in many tyrosine-phosphorylated proteins.
Post-translational modification	Phosphorylated on Tyr-198 and Tyr-220 upon reelin induction in embryonic neurons By similarity. Also phosphorylated on Ser-524 independently of reelin signaling By similarity.
Sequence similarities	Contains 1 PID domain.
Sequence caution	The sequence BAE06094.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Differentiation Neurogenesis
Coding sequence diversity	Alternative splicing Polymorphism
Molecular function	Developmental protein
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Golgi localization Inferred from electronic annotation. Source: Compara adult walking behavior Inferred from electronic annotation. Source: Compara cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration Inferred from electronic annotation. Source: Compara cerebellum structural organization Inferred from electronic annotation. Source: Compara dendrite development Inferred from electronic annotation. Source: Compara midgut development Inferred from electronic annotation. Source: Compara negative regulation of JAK-STAT cascade Inferred from electronic annotation. Source: Compara negative regulation of astrocyte differentiation Inferred from electronic annotation. Source: Compara negative regulation of axonogenesis Inferred from electronic annotation. Source: Compara negative regulation of cell adhesion Inferred from electronic annotation. Source: Compara neuron migration Inferred from electronic annotation. Source: Compara positive regulation of neuron differentiation Inferred from electronic annotation. Source: Compara positive regulation of protein kinase activity Inferred from electronic annotation. Source: Compara radial glia guided migration of Purkinje cell Inferred from electronic annotation. Source: Compara response to drug Inferred from electronic annotation. Source: Compara small GTPase mediated signal transduction Inferred from electronic annotation. Source: Compara ventral spinal cord development Inferred from electronic annotation. Source: Compara
Cellular_component	apical part of cell Inferred from electronic annotation. Source: Compara brush border Inferred from electronic annotation. Source: Compara cytosol Inferred from electronic annotation. Source: Compara membrane Inferred from electronic annotation. Source: Compara neuronal cell body Inferred from electronic annotation. Source: Compara perinuclear region of cytoplasm Inferred from electronic annotation. Source: Compara postsynaptic density Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform DAB588 (identifier: O75553-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform DAB213 (identifier: O75553-2)

The sequence of this isoform differs from the canonical sequence as follows:
     200-213: YIVFEAGHEPIRDP → VISETSRGFRFKSD
     214-588: Missing.

Note: No experimental confirmation available.

Isoform DAB469 (identifier: O75553-3)

The sequence of this isoform differs from the canonical sequence as follows:
     103-221: Missing.

Note: No experimental confirmation available.

Isoform DAB537 (identifier: O75553-4)

The sequence of this isoform differs from the canonical sequence as follows:
     185-219: Missing.
     259-274: Missing.

Note: No experimental confirmation available.

Isoform DAB553 (identifier: O75553-5)

The sequence of this isoform differs from the canonical sequence as follows:
     185-219: Missing.

Note: No experimental confirmation available.

Isoform DAB555 (identifier: O75553-6)

The sequence of this isoform differs from the canonical sequence as follows:
     242-274: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 588	588	Disabled homolog 1		PRO_0000079767
Regions
	Domain	36 – 189	154	PID
Amino acid modifications
	Modified residue	198	1	Phosphotyrosine By similarity
	Modified residue	220	1	Phosphotyrosine By similarity
	Modified residue	232	1	Phosphotyrosine By similarity
	Modified residue	524	1	Phosphoserine; by CDK5 By similarity
Natural variations
	Alternative sequence	103 – 221	119	Missing in isoform DAB469.		VSP_026166
	Alternative sequence	185 – 219	35	Missing in isoform DAB553 and isoform DAB537.		VSP_026167
	Alternative sequence	200 – 213	14	YIVFE…PIRDP → VISETSRGFRFKSD in isoform DAB213.		VSP_026168
	Alternative sequence	214 – 588	375	Missing in isoform DAB213.		VSP_026169
	Alternative sequence	242 – 274	33	Missing in isoform DAB555.		VSP_026170
	Alternative sequence	259 – 274	16	Missing in isoform DAB537.		VSP_026171
	Natural variant	71	1	V → I. Corresponds to variant rs1855377 [ dbSNP | Ensembl ].		VAR_056857
Experimental info
	Sequence conflict	15	1	A → T in AAI12939. Ref.6
	Sequence conflict	59	1	K → M in AAH67447. Ref.6
	Sequence conflict	86	1	F → L in AAF73058. Ref.2
	Sequence conflict	295	1	P → S in AAH67447. Ref.6
	Sequence conflict	324	1	F → L in AAC70068. Ref.1
	Sequence conflict	331	1	S → P in AAC70068. Ref.1
	Sequence conflict	359	1	Q → H in AAC70068. Ref.1
	Sequence conflict	368	1	G → R in AAF73058. Ref.2
	Sequence conflict	412	1	M → V in AAF73058. Ref.2
	Sequence conflict	586	1	A → D in AAC70068. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform DAB588 [UniParc]. Last modified June 26, 2007. Version 3. Checksum: DAD4024364113AC5	FASTA	588	63,775
	10 20 30 40 50 60 MSTETELQVA VKTSAKKDSR KKGQDRSEAT LIKRFKGEGV RYKAKLIGID EVSAARGDKL 70 80 90 100 110 120 CQDSMMKLKG VVAGARSKGE HKQKIFLTIS FGGIKIFDEK TGALQHHHAV HEISYIAKDI 130 140 150 160 170 180 TDHRAFGYVC GKEGNHRFVA IKTAQAAEPV ILDLRDLFQL IYELKQREEL EKKAQKDKQC 190 200 210 220 230 240 EQAVYQTILE EDVEDPVYQY IVFEAGHEPI RDPETEENIY QVPTSQKKEG VYDVPKSQPV 250 260 270 280 290 300 SNGYSFEDFE ERFAAATPNR NLPTDFDEIF EATKAVTQLE LFGDMSTPPD ITSPPTPATP 310 320 330 340 350 360 GDAFIPSSSQ TLPASADVFS SVPFGTAAVP SGYVAMGAVL PSFWGQQPLV QQQMVMGAQP 370 380 390 400 410 420 PVAQVMPGAQ PIAWGQPGLF PATQQPWPTV AGQFPPAAFM PTQTVMPLPA AMFQGPLTPL 430 440 450 460 470 480 ATVPGTSDST RSSPQTDKPR QKMGKETFKD FQMAQPPPVP SRKPDQPSLT CTSEAFSSYF 490 500 510 520 530 540 NKVGVAQDTD DCDDFDISQL NLTPVTSTTP STNSPPTPAP RQSSPSKSSA SHASDPTTDD 550 560 570 580 IFEEGFESPS KSEEQEAPDG SQASSNSDPF GEPSGEPSGD NISPQAGS
	Isoform DAB213 [UniParc]. Checksum: 9A3ADE86341D96E1	FASTA	213	24,091
	10 20 30 40 50 60 MSTETELQVA VKTSAKKDSR KKGQDRSEAT LIKRFKGEGV RYKAKLIGID EVSAARGDKL 70 80 90 100 110 120 CQDSMMKLKG VVAGARSKGE HKQKIFLTIS FGGIKIFDEK TGALQHHHAV HEISYIAKDI 130 140 150 160 170 180 TDHRAFGYVC GKEGNHRFVA IKTAQAAEPV ILDLRDLFQL IYELKQREEL EKKAQKDKQC 190 200 210 EQAVYQTILE EDVEDPVYQV ISETSRGFRF KSD
	Isoform DAB469 [UniParc]. Checksum: 5A03F93BDB4BAF42	FASTA	469	49,856
	10 20 30 40 50 60 MSTETELQVA VKTSAKKDSR KKGQDRSEAT LIKRFKGEGV RYKAKLIGID EVSAARGDKL 70 80 90 100 110 120 CQDSMMKLKG VVAGARSKGE HKQKIFLTIS FGGIKIFDEK TGVPTSQKKE GVYDVPKSQP 130 140 150 160 170 180 VSNGYSFEDF EERFAAATPN RNLPTDFDEI FEATKAVTQL ELFGDMSTPP DITSPPTPAT 190 200 210 220 230 240 PGDAFIPSSS QTLPASADVF SSVPFGTAAV PSGYVAMGAV LPSFWGQQPL VQQQMVMGAQ 250 260 270 280 290 300 PPVAQVMPGA QPIAWGQPGL FPATQQPWPT VAGQFPPAAF MPTQTVMPLP AAMFQGPLTP 310 320 330 340 350 360 LATVPGTSDS TRSSPQTDKP RQKMGKETFK DFQMAQPPPV PSRKPDQPSL TCTSEAFSSY 370 380 390 400 410 420 FNKVGVAQDT DDCDDFDISQ LNLTPVTSTT PSTNSPPTPA PRQSSPSKSS ASHASDPTTD 430 440 450 460 DIFEEGFESP SKSEEQEAPD GSQASSNSDP FGEPSGEPSG DNISPQAGS
	Isoform DAB537 [UniParc]. Checksum: 6626BD99FE7C098C	FASTA	537	57,720
	10 20 30 40 50 60 MSTETELQVA VKTSAKKDSR KKGQDRSEAT LIKRFKGEGV RYKAKLIGID EVSAARGDKL 70 80 90 100 110 120 CQDSMMKLKG VVAGARSKGE HKQKIFLTIS FGGIKIFDEK TGALQHHHAV HEISYIAKDI 130 140 150 160 170 180 TDHRAFGYVC GKEGNHRFVA IKTAQAAEPV ILDLRDLFQL IYELKQREEL EKKAQKDKQC 190 200 210 220 230 240 EQAVYQVPTS QKKEGVYDVP KSQPVSNGYS FEDFEERFAA ATPAVTQLEL FGDMSTPPDI 250 260 270 280 290 300 TSPPTPATPG DAFIPSSSQT LPASADVFSS VPFGTAAVPS GYVAMGAVLP SFWGQQPLVQ 310 320 330 340 350 360 QQMVMGAQPP VAQVMPGAQP IAWGQPGLFP ATQQPWPTVA GQFPPAAFMP TQTVMPLPAA 370 380 390 400 410 420 MFQGPLTPLA TVPGTSDSTR SSPQTDKPRQ KMGKETFKDF QMAQPPPVPS RKPDQPSLTC 430 440 450 460 470 480 TSEAFSSYFN KVGVAQDTDD CDDFDISQLN LTPVTSTTPS TNSPPTPAPR QSSPSKSSAS 490 500 510 520 530 HASDPTTDDI FEEGFESPSK SEEQEAPDGS QASSNSDPFG EPSGEPSGDN ISPQAGS
	Isoform DAB553 [UniParc]. Checksum: 59BC5E84DEF5F583	FASTA	553	59,612
	10 20 30 40 50 60 MSTETELQVA VKTSAKKDSR KKGQDRSEAT LIKRFKGEGV RYKAKLIGID EVSAARGDKL 70 80 90 100 110 120 CQDSMMKLKG VVAGARSKGE HKQKIFLTIS FGGIKIFDEK TGALQHHHAV HEISYIAKDI 130 140 150 160 170 180 TDHRAFGYVC GKEGNHRFVA IKTAQAAEPV ILDLRDLFQL IYELKQREEL EKKAQKDKQC 190 200 210 220 230 240 EQAVYQVPTS QKKEGVYDVP KSQPVSNGYS FEDFEERFAA ATPNRNLPTD FDEIFEATKA 250 260 270 280 290 300 VTQLELFGDM STPPDITSPP TPATPGDAFI PSSSQTLPAS ADVFSSVPFG TAAVPSGYVA 310 320 330 340 350 360 MGAVLPSFWG QQPLVQQQMV MGAQPPVAQV MPGAQPIAWG QPGLFPATQQ PWPTVAGQFP 370 380 390 400 410 420 PAAFMPTQTV MPLPAAMFQG PLTPLATVPG TSDSTRSSPQ TDKPRQKMGK ETFKDFQMAQ 430 440 450 460 470 480 PPPVPSRKPD QPSLTCTSEA FSSYFNKVGV AQDTDDCDDF DISQLNLTPV TSTTPSTNSP 490 500 510 520 530 540 PTPAPRQSSP SKSSASHASD PTTDDIFEEG FESPSKSEEQ EAPDGSQASS NSDPFGEPSG 550 EPSGDNISPQ AGS
	Isoform DAB555 [UniParc]. Checksum: 9EB4FC3D31BBF8CB	FASTA	555	59,950
	10 20 30 40 50 60 MSTETELQVA VKTSAKKDSR KKGQDRSEAT LIKRFKGEGV RYKAKLIGID EVSAARGDKL 70 80 90 100 110 120 CQDSMMKLKG VVAGARSKGE HKQKIFLTIS FGGIKIFDEK TGALQHHHAV HEISYIAKDI 130 140 150 160 170 180 TDHRAFGYVC GKEGNHRFVA IKTAQAAEPV ILDLRDLFQL IYELKQREEL EKKAQKDKQC 190 200 210 220 230 240 EQAVYQTILE EDVEDPVYQY IVFEAGHEPI RDPETEENIY QVPTSQKKEG VYDVPKSQPV 250 260 270 280 290 300 SAVTQLELFG DMSTPPDITS PPTPATPGDA FIPSSSQTLP ASADVFSSVP FGTAAVPSGY 310 320 330 340 350 360 VAMGAVLPSF WGQQPLVQQQ MVMGAQPPVA QVMPGAQPIA WGQPGLFPAT QQPWPTVAGQ 370 380 390 400 410 420 FPPAAFMPTQ TVMPLPAAMF QGPLTPLATV PGTSDSTRSS PQTDKPRQKM GKETFKDFQM 430 440 450 460 470 480 AQPPPVPSRK PDQPSLTCTS EAFSSYFNKV GVAQDTDDCD DFDISQLNLT PVTSTTPSTN 490 500 510 520 530 540 SPPTPAPRQS SPSKSSASHA SDPTTDDIFE EGFESPSKSE EQEAPDGSQA SSNSDPFGEP 550 SGEPSGDNIS PQAGS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of human DAB1 and mapping to chromosome 1p31-p32." Lambert de Rouvroit C., Goffinet A.M. Genomics 53:246-247(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM DAB555).
[2]	"Aberrant disabled-1 expression in tumors." Fazili Z., Sun W., Xu X.-X. Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM DAB555).
[3]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM DAB555). Tissue: Brain.
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS DAB469; DAB537 AND DAB553).
[7]	"Serine and threonine phosphorylation of the low density lipoprotein receptor-related protein by protein kinase Calpha regulates endocytosis and association with adaptor molecules." Ranganathan S., Liu C.-X., Migliorini M.M., Von Arnim C.A.F., Peltan I.D., Mikhailenko I., Hyman B.T., Strickland D.K. J. Biol. Chem. 279:40536-40544(2004) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH LRP1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF071062 mRNA. Translation: AAC70068.1. AF263547 mRNA. Translation: AAF73058.1. AL139219, AL354883 Genomic DNA. Translation: CAI19217.1. AL139219, AL161740, AL354883 Genomic DNA. Translation: CAI19218.1. AL139219, AL161740, AL354883 Genomic DNA. Translation: CAI19219.1. AL139219, AL354883 Genomic DNA. Translation: CAI19220.1. AL139219, AL161740, AL354883 Genomic DNA. Translation: CAI19221.1. AL161740, AL139219, AL354883 Genomic DNA. Translation: CAI18815.1. AL161740, AL139219, AL354883 Genomic DNA. Translation: CAI18816.1. AL161740, AL139219, AL354883 Genomic DNA. Translation: CAI18817.1. AL354883, AL139219 Genomic DNA. Translation: CAI22360.1. AL354883, AL139219, AL161740 Genomic DNA. Translation: CAI22361.1. AL354883, AL139219, AL161740 Genomic DNA. Translation: CAI22362.1. AL354883, AL139219 Genomic DNA. Translation: CAI22363.1. AL354883, AL139219, AL161740 Genomic DNA. Translation: CAI22364.1. AK095513 mRNA. Translation: BAG53075.1. AB210012 mRNA. Translation: BAE06094.1. Different initiation. CH471059 Genomic DNA. Translation: EAX06637.1. BC067445 mRNA. Translation: AAH67445.1. BC067446 mRNA. Translation: AAH67446.1. BC067447 mRNA. Translation: AAH67447.1. BC112938 mRNA. Translation: AAI12939.1.
IPI	IPI00026889. IPI00433142. IPI00433150. IPI00514371. IPI00514638. IPI00847156.
RefSeq	NP_066566.3. NM_021080.3.
UniGene	Hs.477370.
3D structure databases
ProteinModelPortal	O75553.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-156038.
PTM databases
PhosphoSite	O75553.
Proteomic databases
PaxDb	O75553.
PRIDE	O75553.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000332102; ENSP00000329120; ENSG00000173406. ENST00000371230; ENSP00000360274; ENSG00000173406. ENST00000371231; ENSP00000360275; ENSG00000173406. ENST00000371232; ENSP00000360276; ENSG00000173406. ENST00000371233; ENSP00000360277; ENSG00000173406. ENST00000371234; ENSP00000360278; ENSG00000173406. ENST00000371236; ENSP00000360280; ENSG00000173406. ENST00000414851; ENSP00000387581; ENSG00000173406. ENST00000420954; ENSP00000395296; ENSG00000173406. ENST00000439789; ENSP00000409328; ENSG00000173406.
GeneID	1600.
KEGG	hsa:1600.
UCSC	uc001cyq.1. human. uc001cyr.1. human. uc001cys.1. human. uc001cyt.1. human. uc009vzw.1. human.
Organism-specific databases
CTD	1600.
GeneCards	GC01M057460.
HGNC	HGNC:2661. DAB1.
HPA	CAB032329.
MIM	603448. gene.
neXtProt	NX_O75553.
PharmGKB	PA27131.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG313182.
HOVERGEN	HBG018945.
InParanoid	O75553.
OMA	AAFMPTQ.
Enzyme and pathway databases
Pathway_Interaction_DB	lis1pathway. Lissencephaly gene (LIS1) in neuronal migration and development. reelinpathway. Reelin signaling pathway.
Gene expression databases
ArrayExpress	O75553.
Bgee	O75553.
Genevestigator	O75553.
GermOnline	ENSG00000173406. Homo sapiens.
Family and domain databases
Gene3D	2.30.29.30. 1 hit.
InterPro	IPR011993. PH_like_dom. IPR006020. PTyr_interaction_dom. [Graphical view]
Pfam	PF00640. PID. 1 hit. [Graphical view]
SMART	SM00462. PTB. 1 hit. [Graphical view]
PROSITE	PS01179. PID. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	DAB1. human.
GenomeRNAi	1600.
NextBio	6562.
SOURCE	Search...

Entry information

Entry name

DAB1_HUMAN

Accession

Primary (citable) accession number: O75553
Secondary accession number(s): A4FU90 , B3KTG3, Q4LE59, Q5T6M6, Q5T6M9, Q5T835, Q5T836, Q5T837, Q6NWS9, Q6NWT0, Q6NWT1, Q9NYA8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 11, 2002
Last sequence update:	June 26, 2007
Last modified:	May 1, 2013
This is version 100 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.