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O75553

- DAB1_HUMAN

UniProt

O75553 - DAB1_HUMAN

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Protein

Disabled homolog 1

Gene

DAB1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Adapter molecule functioning in neural development. May regulate SIAH1 activity (By similarity).By similarity

GO - Biological processi

  1. adult walking behavior Source: Ensembl
  2. cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration Source: Ensembl
  3. cerebellum structural organization Source: Ensembl
  4. dendrite development Source: Ensembl
  5. Golgi localization Source: Ensembl
  6. lateral motor column neuron migration Source: Ensembl
  7. midgut development Source: Ensembl
  8. negative regulation of astrocyte differentiation Source: Ensembl
  9. negative regulation of axonogenesis Source: Ensembl
  10. negative regulation of cell adhesion Source: Ensembl
  11. negative regulation of JAK-STAT cascade Source: Ensembl
  12. positive regulation of neuron differentiation Source: Ensembl
  13. positive regulation of protein kinase activity Source: Ensembl
  14. radial glia guided migration of Purkinje cell Source: Ensembl
  15. response to drug Source: Ensembl
  16. small GTPase mediated signal transduction Source: Ensembl
  17. ventral spinal cord development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Enzyme and pathway databases

SignaLinkiO75553.

Names & Taxonomyi

Protein namesi
Recommended name:
Disabled homolog 1
Gene namesi
Name:DAB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:2661. DAB1.

Subcellular locationi

GO - Cellular componenti

  1. apical part of cell Source: Ensembl
  2. brush border Source: Ensembl
  3. cytosol Source: Ensembl
  4. membrane Source: Ensembl
  5. neuronal cell body Source: Ensembl
  6. neuron projection Source: Ensembl
  7. perinuclear region of cytoplasm Source: Ensembl
  8. postsynaptic density Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27131.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 588588Disabled homolog 1PRO_0000079767Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei198 – 1981PhosphotyrosineBy similarity
Modified residuei220 – 2201PhosphotyrosineBy similarity
Modified residuei232 – 2321PhosphotyrosineBy similarity
Modified residuei524 – 5241Phosphoserine; by CDK5By similarity

Post-translational modificationi

Phosphorylated on Tyr-198 and Tyr-220 upon reelin induction in embryonic neurons. Also phosphorylated on Ser-524 independently of reelin signaling.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO75553.
PRIDEiO75553.

PTM databases

PhosphoSiteiO75553.

Expressioni

Gene expression databases

BgeeiO75553.
ExpressionAtlasiO75553. baseline and differential.
GenevestigatoriO75553.

Organism-specific databases

HPAiCAB032329.

Interactioni

Subunit structurei

Associates with the SH2 domains of SRC, FYN and ABL. Interacts (phosphorylated on tyrosine residues) with CRK and CRKL (via respective SH2 domain). Interacts with DAB2IP, SIAH1, LRP1, LRP8 and VLDLR.1 Publication

Protein-protein interaction databases

BioGridi107970. 18 interactions.
IntActiO75553. 2 interactions.
MINTiMINT-156038.

Structurei

3D structure databases

ProteinModelPortaliO75553.
SMRiO75553. Positions 23-174.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 189154PIDPROSITE-ProRule annotationAdd
BLAST

Domaini

The PID domain specifically binds to the Asn-Pro-Xaa-Tyr(P) motif found in many tyrosine-phosphorylated proteins.

Sequence similaritiesi

Contains 1 PID domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG313182.
GeneTreeiENSGT00520000055585.
HOVERGENiHBG018945.
InParanoidiO75553.
OMAiFQMAQPP.
OrthoDBiEOG7HQN7R.
PhylomeDBiO75553.
TreeFamiTF316724.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_like_dom.
IPR006020. PTB/PI_dom.
[Graphical view]
PfamiPF00640. PID. 1 hit.
[Graphical view]
SMARTiSM00462. PTB. 1 hit.
[Graphical view]
PROSITEiPS01179. PID. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. Align

Isoform DAB588 (identifier: O75553-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSTETELQVA VKTSAKKDSR KKGQDRSEAT LIKRFKGEGV RYKAKLIGID
60 70 80 90 100
EVSAARGDKL CQDSMMKLKG VVAGARSKGE HKQKIFLTIS FGGIKIFDEK
110 120 130 140 150
TGALQHHHAV HEISYIAKDI TDHRAFGYVC GKEGNHRFVA IKTAQAAEPV
160 170 180 190 200
ILDLRDLFQL IYELKQREEL EKKAQKDKQC EQAVYQTILE EDVEDPVYQY
210 220 230 240 250
IVFEAGHEPI RDPETEENIY QVPTSQKKEG VYDVPKSQPV SNGYSFEDFE
260 270 280 290 300
ERFAAATPNR NLPTDFDEIF EATKAVTQLE LFGDMSTPPD ITSPPTPATP
310 320 330 340 350
GDAFIPSSSQ TLPASADVFS SVPFGTAAVP SGYVAMGAVL PSFWGQQPLV
360 370 380 390 400
QQQMVMGAQP PVAQVMPGAQ PIAWGQPGLF PATQQPWPTV AGQFPPAAFM
410 420 430 440 450
PTQTVMPLPA AMFQGPLTPL ATVPGTSDST RSSPQTDKPR QKMGKETFKD
460 470 480 490 500
FQMAQPPPVP SRKPDQPSLT CTSEAFSSYF NKVGVAQDTD DCDDFDISQL
510 520 530 540 550
NLTPVTSTTP STNSPPTPAP RQSSPSKSSA SHASDPTTDD IFEEGFESPS
560 570 580
KSEEQEAPDG SQASSNSDPF GEPSGEPSGD NISPQAGS

Note: No experimental confirmation available.

Length:588
Mass (Da):63,775
Last modified:June 26, 2007 - v3
Checksum:iDAD4024364113AC5
GO
Isoform DAB213 (identifier: O75553-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     200-213: YIVFEAGHEPIRDP → VISETSRGFRFKSD
     214-588: Missing.

Note: No experimental confirmation available.

Show »
Length:213
Mass (Da):24,091
Checksum:i9A3ADE86341D96E1
GO
Isoform DAB469 (identifier: O75553-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     103-221: Missing.

Note: No experimental confirmation available.

Show »
Length:469
Mass (Da):49,856
Checksum:i5A03F93BDB4BAF42
GO
Isoform DAB537 (identifier: O75553-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     185-219: Missing.
     259-274: Missing.

Note: No experimental confirmation available.

Show »
Length:537
Mass (Da):57,720
Checksum:i6626BD99FE7C098C
GO
Isoform DAB553 (identifier: O75553-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     185-219: Missing.

Note: No experimental confirmation available.

Show »
Length:553
Mass (Da):59,612
Checksum:i59BC5E84DEF5F583
GO
Isoform DAB555 (identifier: O75553-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     242-274: Missing.

Show »
Length:555
Mass (Da):59,950
Checksum:i9EB4FC3D31BBF8CB
GO

Sequence cautioni

The sequence BAE06094.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti15 – 151A → T in AAI12939. (PubMed:15489334)Curated
Sequence conflicti59 – 591K → M in AAH67447. (PubMed:15489334)Curated
Sequence conflicti86 – 861F → L in AAF73058. 1 PublicationCurated
Sequence conflicti295 – 2951P → S in AAH67447. (PubMed:15489334)Curated
Sequence conflicti324 – 3241F → L in AAC70068. (PubMed:9790777)Curated
Sequence conflicti331 – 3311S → P in AAC70068. (PubMed:9790777)Curated
Sequence conflicti359 – 3591Q → H in AAC70068. (PubMed:9790777)Curated
Sequence conflicti368 – 3681G → R in AAF73058. 1 PublicationCurated
Sequence conflicti412 – 4121M → V in AAF73058. 1 PublicationCurated
Sequence conflicti586 – 5861A → D in AAC70068. (PubMed:9790777)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti71 – 711V → I.
Corresponds to variant rs1855377 [ dbSNP | Ensembl ].
VAR_056857

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei103 – 221119Missing in isoform DAB469. 1 PublicationVSP_026166Add
BLAST
Alternative sequencei185 – 21935Missing in isoform DAB553 and isoform DAB537. 1 PublicationVSP_026167Add
BLAST
Alternative sequencei200 – 21314YIVFE…PIRDP → VISETSRGFRFKSD in isoform DAB213. CuratedVSP_026168Add
BLAST
Alternative sequencei214 – 588375Missing in isoform DAB213. CuratedVSP_026169Add
BLAST
Alternative sequencei242 – 27433Missing in isoform DAB555. 3 PublicationsVSP_026170Add
BLAST
Alternative sequencei259 – 27416Missing in isoform DAB537. 1 PublicationVSP_026171Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071062 mRNA. Translation: AAC70068.1.
AF263547 mRNA. Translation: AAF73058.1.
AL139219, AL354883 Genomic DNA. Translation: CAI19217.1.
AL139219, AL161740, AL354883 Genomic DNA. Translation: CAI19218.1.
AL139219, AL161740, AL354883 Genomic DNA. Translation: CAI19219.1.
AL139219, AL354883 Genomic DNA. Translation: CAI19220.1.
AL139219, AL161740, AL354883 Genomic DNA. Translation: CAI19221.1.
AL161740, AL139219, AL354883 Genomic DNA. Translation: CAI18815.1.
AL161740, AL139219, AL354883 Genomic DNA. Translation: CAI18816.1.
AL161740, AL139219, AL354883 Genomic DNA. Translation: CAI18817.1.
AL354883, AL139219 Genomic DNA. Translation: CAI22360.1.
AL354883, AL139219, AL161740 Genomic DNA. Translation: CAI22361.1.
AL354883, AL139219, AL161740 Genomic DNA. Translation: CAI22362.1.
AL354883, AL139219 Genomic DNA. Translation: CAI22363.1.
AL354883, AL139219, AL161740 Genomic DNA. Translation: CAI22364.1.
AK095513 mRNA. Translation: BAG53075.1.
AB210012 mRNA. Translation: BAE06094.1. Different initiation.
CH471059 Genomic DNA. Translation: EAX06637.1.
BC067445 mRNA. Translation: AAH67445.1.
BC067446 mRNA. Translation: AAH67446.1.
BC067447 mRNA. Translation: AAH67447.1.
BC112938 mRNA. Translation: AAI12939.1.
CCDSiCCDS607.1. [O75553-6]
RefSeqiNP_066566.3. NM_021080.3. [O75553-6]
UniGeneiHs.477370.

Genome annotation databases

EnsembliENST00000371230; ENSP00000360274; ENSG00000173406. [O75553-2]
ENST00000371231; ENSP00000360275; ENSG00000173406. [O75553-1]
ENST00000371236; ENSP00000360280; ENSG00000173406. [O75553-6]
ENST00000414851; ENSP00000387581; ENSG00000173406. [O75553-6]
ENST00000420954; ENSP00000395296; ENSG00000173406. [O75553-5]
GeneIDi1600.
KEGGihsa:1600.
UCSCiuc001cyq.1. human. [O75553-5]
uc001cyr.1. human. [O75553-3]
uc001cys.1. human. [O75553-6]
uc001cyt.1. human. [O75553-1]
uc009vzw.1. human. [O75553-4]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071062 mRNA. Translation: AAC70068.1 .
AF263547 mRNA. Translation: AAF73058.1 .
AL139219 , AL354883 Genomic DNA. Translation: CAI19217.1 .
AL139219 , AL161740 , AL354883 Genomic DNA. Translation: CAI19218.1 .
AL139219 , AL161740 , AL354883 Genomic DNA. Translation: CAI19219.1 .
AL139219 , AL354883 Genomic DNA. Translation: CAI19220.1 .
AL139219 , AL161740 , AL354883 Genomic DNA. Translation: CAI19221.1 .
AL161740 , AL139219 , AL354883 Genomic DNA. Translation: CAI18815.1 .
AL161740 , AL139219 , AL354883 Genomic DNA. Translation: CAI18816.1 .
AL161740 , AL139219 , AL354883 Genomic DNA. Translation: CAI18817.1 .
AL354883 , AL139219 Genomic DNA. Translation: CAI22360.1 .
AL354883 , AL139219 , AL161740 Genomic DNA. Translation: CAI22361.1 .
AL354883 , AL139219 , AL161740 Genomic DNA. Translation: CAI22362.1 .
AL354883 , AL139219 Genomic DNA. Translation: CAI22363.1 .
AL354883 , AL139219 , AL161740 Genomic DNA. Translation: CAI22364.1 .
AK095513 mRNA. Translation: BAG53075.1 .
AB210012 mRNA. Translation: BAE06094.1 . Different initiation.
CH471059 Genomic DNA. Translation: EAX06637.1 .
BC067445 mRNA. Translation: AAH67445.1 .
BC067446 mRNA. Translation: AAH67446.1 .
BC067447 mRNA. Translation: AAH67447.1 .
BC112938 mRNA. Translation: AAI12939.1 .
CCDSi CCDS607.1. [O75553-6 ]
RefSeqi NP_066566.3. NM_021080.3. [O75553-6 ]
UniGenei Hs.477370.

3D structure databases

ProteinModelPortali O75553.
SMRi O75553. Positions 23-174.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107970. 18 interactions.
IntActi O75553. 2 interactions.
MINTi MINT-156038.

PTM databases

PhosphoSitei O75553.

Proteomic databases

PaxDbi O75553.
PRIDEi O75553.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000371230 ; ENSP00000360274 ; ENSG00000173406 . [O75553-2 ]
ENST00000371231 ; ENSP00000360275 ; ENSG00000173406 . [O75553-1 ]
ENST00000371236 ; ENSP00000360280 ; ENSG00000173406 . [O75553-6 ]
ENST00000414851 ; ENSP00000387581 ; ENSG00000173406 . [O75553-6 ]
ENST00000420954 ; ENSP00000395296 ; ENSG00000173406 . [O75553-5 ]
GeneIDi 1600.
KEGGi hsa:1600.
UCSCi uc001cyq.1. human. [O75553-5 ]
uc001cyr.1. human. [O75553-3 ]
uc001cys.1. human. [O75553-6 ]
uc001cyt.1. human. [O75553-1 ]
uc009vzw.1. human. [O75553-4 ]

Organism-specific databases

CTDi 1600.
GeneCardsi GC01M057460.
HGNCi HGNC:2661. DAB1.
HPAi CAB032329.
MIMi 603448. gene.
neXtProti NX_O75553.
PharmGKBi PA27131.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG313182.
GeneTreei ENSGT00520000055585.
HOVERGENi HBG018945.
InParanoidi O75553.
OMAi FQMAQPP.
OrthoDBi EOG7HQN7R.
PhylomeDBi O75553.
TreeFami TF316724.

Enzyme and pathway databases

SignaLinki O75553.

Miscellaneous databases

ChiTaRSi DAB1. human.
GeneWikii DAB1.
GenomeRNAii 1600.
NextBioi 6562.
PROi O75553.
SOURCEi Search...

Gene expression databases

Bgeei O75553.
ExpressionAtlasi O75553. baseline and differential.
Genevestigatori O75553.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
InterProi IPR011993. PH_like_dom.
IPR006020. PTB/PI_dom.
[Graphical view ]
Pfami PF00640. PID. 1 hit.
[Graphical view ]
SMARTi SM00462. PTB. 1 hit.
[Graphical view ]
PROSITEi PS01179. PID. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of human DAB1 and mapping to chromosome 1p31-p32."
    Lambert de Rouvroit C., Goffinet A.M.
    Genomics 53:246-247(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM DAB555).
  2. "Aberrant disabled-1 expression in tumors."
    Fazili Z., Sun W., Xu X.-X.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM DAB555).
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM DAB555).
    Tissue: Brain.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS DAB469; DAB537 AND DAB553).
  7. "Serine and threonine phosphorylation of the low density lipoprotein receptor-related protein by protein kinase Calpha regulates endocytosis and association with adaptor molecules."
    Ranganathan S., Liu C.-X., Migliorini M.M., Von Arnim C.A.F., Peltan I.D., Mikhailenko I., Hyman B.T., Strickland D.K.
    J. Biol. Chem. 279:40536-40544(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH LRP1.

Entry informationi

Entry nameiDAB1_HUMAN
AccessioniPrimary (citable) accession number: O75553
Secondary accession number(s): A4FU90
, B3KTG3, Q4LE59, Q5T6M6, Q5T6M9, Q5T835, Q5T836, Q5T837, Q6NWS9, Q6NWT0, Q6NWT1, Q9NYA8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: June 26, 2007
Last modified: October 29, 2014
This is version 114 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

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