ID ZN821_HUMAN Reviewed; 412 AA. AC O75541; A6NK48; B4DKK4; D3DWS3; DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot. DT 16-MAY-2012, sequence version 3. DT 27-MAR-2024, entry version 190. DE RecName: Full=Zinc finger protein 821; GN Name=ZNF821; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). RC TISSUE=Brain; RA Yu W., Gibbs R.A.; RL Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Colon; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15616553; DOI=10.1038/nature03187; RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M., RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., RA Myers R.M., Rubin E.M., Pennacchio L.A.; RT "The sequence and analysis of duplication-rich human chromosome 16."; RL Nature 432:988-994(2004). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). RC TISSUE=Uterus; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: May be involved in transcriptional regulation. CC -!- INTERACTION: CC O75541; Q96GN5: CDCA7L; NbExp=3; IntAct=EBI-740865, EBI-5278764; CC O75541; Q9P1W9: PIM2; NbExp=3; IntAct=EBI-740865, EBI-720425; CC O75541-2; Q92997: DVL3; NbExp=3; IntAct=EBI-14544035, EBI-739789; CC O75541-2; Q59EK9-3: RUNDC3A; NbExp=3; IntAct=EBI-14544035, EBI-11957366; CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=O75541-1; Sequence=Displayed; CC Name=2; CC IsoId=O75541-2; Sequence=VSP_030933; CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein CC family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF070588; AAC28648.1; -; mRNA. DR EMBL; AK296603; BAG59216.1; -; mRNA. DR EMBL; AC009127; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC010653; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471166; EAW59211.1; -; Genomic_DNA. DR EMBL; CH471166; EAW59213.1; -; Genomic_DNA. DR EMBL; CH471166; EAW59214.1; -; Genomic_DNA. DR EMBL; CH471166; EAW59219.1; -; Genomic_DNA. DR EMBL; BC012116; AAH12116.1; -; mRNA. DR CCDS; CCDS32481.1; -. [O75541-2] DR CCDS; CCDS56006.1; -. [O75541-1] DR RefSeq; NP_001188481.1; NM_001201552.1. [O75541-1] DR RefSeq; NP_001188482.1; NM_001201553.1. [O75541-1] DR RefSeq; NP_001188483.1; NM_001201554.1. DR RefSeq; NP_001188485.1; NM_001201556.1. DR RefSeq; NP_060000.1; NM_017530.2. DR RefSeq; XP_005256090.1; XM_005256033.2. DR RefSeq; XP_006721296.1; XM_006721233.1. DR RefSeq; XP_011521513.1; XM_011523211.2. [O75541-1] DR RefSeq; XP_016878898.1; XM_017023409.1. DR RefSeq; XP_016878899.1; XM_017023410.1. DR RefSeq; XP_016878900.1; XM_017023411.1. DR RefSeq; XP_016878901.1; XM_017023412.1. DR RefSeq; XP_016878903.1; XM_017023414.1. DR AlphaFoldDB; O75541; -. DR SMR; O75541; -. DR BioGRID; 120720; 12. DR IntAct; O75541; 11. DR MINT; O75541; -. DR STRING; 9606.ENSP00000398089; -. DR GlyCosmos; O75541; 1 site, 1 glycan. DR GlyGen; O75541; 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site). DR iPTMnet; O75541; -. DR PhosphoSitePlus; O75541; -. DR BioMuta; ZNF821; -. DR MassIVE; O75541; -. DR PaxDb; 9606-ENSP00000398089; -. DR PeptideAtlas; O75541; -. DR ProteomicsDB; 50075; -. [O75541-1] DR ProteomicsDB; 50076; -. [O75541-2] DR Antibodypedia; 16662; 115 antibodies from 22 providers. DR DNASU; 55565; -. DR Ensembl; ENST00000425432.6; ENSP00000398089.1; ENSG00000102984.15. [O75541-1] DR Ensembl; ENST00000565601.5; ENSP00000455648.1; ENSG00000102984.15. [O75541-1] DR GeneID; 55565; -. DR KEGG; hsa:55565; -. DR MANE-Select; ENST00000425432.6; ENSP00000398089.1; NM_001201552.2; NP_001188481.1. DR UCSC; uc002fbf.4; human. [O75541-1] DR AGR; HGNC:28043; -. DR CTD; 55565; -. DR DisGeNET; 55565; -. DR GeneCards; ZNF821; -. DR HGNC; HGNC:28043; ZNF821. DR HPA; ENSG00000102984; Tissue enhanced (brain, testis). DR neXtProt; NX_O75541; -. DR OpenTargets; ENSG00000102984; -. DR PharmGKB; PA162410689; -. DR VEuPathDB; HostDB:ENSG00000102984; -. DR eggNOG; KOG1721; Eukaryota. DR GeneTree; ENSGT00940000159421; -. DR InParanoid; O75541; -. DR OMA; NNCVAYR; -. DR OrthoDB; 4336269at2759; -. DR PhylomeDB; O75541; -. DR TreeFam; TF326851; -. DR PathwayCommons; O75541; -. DR SignaLink; O75541; -. DR BioGRID-ORCS; 55565; 10 hits in 1174 CRISPR screens. DR ChiTaRS; ZNF821; human. DR GenomeRNAi; 55565; -. DR Pharos; O75541; Tdark. DR PRO; PR:O75541; -. DR Proteomes; UP000005640; Chromosome 16. DR RNAct; O75541; Protein. DR Bgee; ENSG00000102984; Expressed in cortical plate and 114 other cell types or tissues. DR ExpressionAtlas; O75541; baseline and differential. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central. DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL. DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central. DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1. DR InterPro; IPR036236; Znf_C2H2_sf. DR InterPro; IPR013087; Znf_C2H2_type. DR PANTHER; PTHR24409:SF295; LD43035P; 1. DR PANTHER; PTHR24409; ZINC FINGER PROTEIN 142; 1. DR Pfam; PF00096; zf-C2H2; 1. DR SMART; SM00355; ZnF_C2H2; 2. DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 1. DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2. DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1. DR Genevisible; O75541; HS. PE 1: Evidence at protein level; KW Alternative splicing; Coiled coil; DNA-binding; Metal-binding; Nucleus; KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; KW Zinc-finger. FT CHAIN 1..412 FT /note="Zinc finger protein 821" FT /id="PRO_0000317289" FT ZN_FING 116..140 FT /note="C2H2-type 1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 150..172 FT /note="C2H2-type 2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT REGION 26..83 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 278..319 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 257..366 FT /evidence="ECO:0000255" FT COMPBIAS 39..53 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 67..83 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT VAR_SEQ 16..57 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:15489334, ECO:0000303|Ref.1" FT /id="VSP_030933" SQ SEQUENCE 412 AA; 46794 MW; B3C953147F1C4E5C CRC64; MSRRKQTNPN KVHWDQVFAG LEEQARQAMM KTDFPGDLGS QRQAIQQLRD QDSSSSDSEG DEEETTQDEV SSHTSEEDGG VVKVEKELEN TEQPVGGNEV VEHEVTGNLN SDPLLELCQC PLCQLDCGSR EQLIAHVYQH TAAVVSAKSY MCPVCGRALS SPGSLGRHLL IHSEDQRSNC AVCGARFTSH ATFNSEKLPE VLNMESLPTV HNEGPSSAEG KDIAFSPPVY PAGILLVCNN CAAYRKLLEA QTPSVRKWAL RRQNEPLEVR LQRLERERTA KKSRRDNETP EEREVRRMRD REAKRLQRMQ ETDEQRARRL QRDREAMRLK RANETPEKRQ ARLIREREAK RLKRRLEKMD MMLRAQFGQD PSAMAALAAE MNFFQLPVSG VELDSQLLGK MAFEEQNSSS LH //