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Protein

Zinc finger protein 821

Gene

ZNF821

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri116 – 14025C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri150 – 17223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 821
Gene namesi
Name:ZNF821
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:28043. ZNF821.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162410689.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 412412Zinc finger protein 821PRO_0000317289Add
BLAST

Proteomic databases

PaxDbiO75541.
PRIDEiO75541.

PTM databases

PhosphoSiteiO75541.

Expressioni

Gene expression databases

BgeeiO75541.
CleanExiHS_ZNF821.
ExpressionAtlasiO75541. baseline and differential.
GenevestigatoriO75541.

Organism-specific databases

HPAiHPA036372.
HPA042742.

Interactioni

Protein-protein interaction databases

BioGridi120720. 4 interactions.
IntActiO75541. 2 interactions.
MINTiMINT-1442999.

Structurei

3D structure databases

ProteinModelPortaliO75541.
SMRiO75541. Positions 108-181.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili257 – 366110Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 2 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri116 – 14025C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri150 – 17223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG247293.
GeneTreeiENSGT00720000108795.
HOGENOMiHOG000069989.
HOVERGENiHBG053151.
InParanoidiO75541.
OMAiCPLCQLE.
PhylomeDBiO75541.
TreeFamiTF326851.

Family and domain databases

Gene3Di3.30.160.60. 1 hit.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 2 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O75541-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRRKQTNPN KVHWDQVFAG LEEQARQAMM KTDFPGDLGS QRQAIQQLRD
60 70 80 90 100
QDSSSSDSEG DEEETTQDEV SSHTSEEDGG VVKVEKELEN TEQPVGGNEV
110 120 130 140 150
VEHEVTGNLN SDPLLELCQC PLCQLDCGSR EQLIAHVYQH TAAVVSAKSY
160 170 180 190 200
MCPVCGRALS SPGSLGRHLL IHSEDQRSNC AVCGARFTSH ATFNSEKLPE
210 220 230 240 250
VLNMESLPTV HNEGPSSAEG KDIAFSPPVY PAGILLVCNN CAAYRKLLEA
260 270 280 290 300
QTPSVRKWAL RRQNEPLEVR LQRLERERTA KKSRRDNETP EEREVRRMRD
310 320 330 340 350
REAKRLQRMQ ETDEQRARRL QRDREAMRLK RANETPEKRQ ARLIREREAK
360 370 380 390 400
RLKRRLEKMD MMLRAQFGQD PSAMAALAAE MNFFQLPVSG VELDSQLLGK
410
MAFEEQNSSS LH

Note: No experimental confirmation available.

Length:412
Mass (Da):46,794
Last modified:May 16, 2012 - v3
Checksum:iB3C953147F1C4E5C
GO
Isoform 2 (identifier: O75541-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     16-57: Missing.

Show »
Length:370
Mass (Da):42,140
Checksum:i383D2D7EFAC1BEB5
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei16 – 5742Missing in isoform 2. 2 PublicationsVSP_030933Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF070588 mRNA. Translation: AAC28648.1.
AK296603 mRNA. Translation: BAG59216.1.
AC009127 Genomic DNA. No translation available.
AC010653 Genomic DNA. No translation available.
CH471166 Genomic DNA. Translation: EAW59211.1.
CH471166 Genomic DNA. Translation: EAW59213.1.
CH471166 Genomic DNA. Translation: EAW59214.1.
CH471166 Genomic DNA. Translation: EAW59219.1.
BC012116 mRNA. Translation: AAH12116.1.
CCDSiCCDS32481.1. [O75541-2]
CCDS56006.1. [O75541-1]
RefSeqiNP_001188481.1. NM_001201552.1. [O75541-1]
NP_001188482.1. NM_001201553.1. [O75541-1]
NP_001188483.1. NM_001201554.1.
NP_001188485.1. NM_001201556.1.
NP_060000.1. NM_017530.2.
XP_005256090.1. XM_005256033.1. [O75541-1]
XP_006721296.1. XM_006721233.1. [O75541-1]
UniGeneiHs.744055.

Genome annotation databases

EnsembliENST00000313565; ENSP00000313822; ENSG00000102984.
ENST00000425432; ENSP00000398089; ENSG00000102984. [O75541-1]
ENST00000446827; ENSP00000405908; ENSG00000102984.
ENST00000565601; ENSP00000455648; ENSG00000102984. [O75541-1]
GeneIDi55565.
KEGGihsa:55565.
UCSCiuc002fbe.3. human. [O75541-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF070588 mRNA. Translation: AAC28648.1.
AK296603 mRNA. Translation: BAG59216.1.
AC009127 Genomic DNA. No translation available.
AC010653 Genomic DNA. No translation available.
CH471166 Genomic DNA. Translation: EAW59211.1.
CH471166 Genomic DNA. Translation: EAW59213.1.
CH471166 Genomic DNA. Translation: EAW59214.1.
CH471166 Genomic DNA. Translation: EAW59219.1.
BC012116 mRNA. Translation: AAH12116.1.
CCDSiCCDS32481.1. [O75541-2]
CCDS56006.1. [O75541-1]
RefSeqiNP_001188481.1. NM_001201552.1. [O75541-1]
NP_001188482.1. NM_001201553.1. [O75541-1]
NP_001188483.1. NM_001201554.1.
NP_001188485.1. NM_001201556.1.
NP_060000.1. NM_017530.2.
XP_005256090.1. XM_005256033.1. [O75541-1]
XP_006721296.1. XM_006721233.1. [O75541-1]
UniGeneiHs.744055.

3D structure databases

ProteinModelPortaliO75541.
SMRiO75541. Positions 108-181.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120720. 4 interactions.
IntActiO75541. 2 interactions.
MINTiMINT-1442999.

PTM databases

PhosphoSiteiO75541.

Proteomic databases

PaxDbiO75541.
PRIDEiO75541.

Protocols and materials databases

DNASUi55565.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313565; ENSP00000313822; ENSG00000102984.
ENST00000425432; ENSP00000398089; ENSG00000102984. [O75541-1]
ENST00000446827; ENSP00000405908; ENSG00000102984.
ENST00000565601; ENSP00000455648; ENSG00000102984. [O75541-1]
GeneIDi55565.
KEGGihsa:55565.
UCSCiuc002fbe.3. human. [O75541-1]

Organism-specific databases

CTDi55565.
GeneCardsiGC16M071893.
HGNCiHGNC:28043. ZNF821.
HPAiHPA036372.
HPA042742.
neXtProtiNX_O75541.
PharmGKBiPA162410689.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG247293.
GeneTreeiENSGT00720000108795.
HOGENOMiHOG000069989.
HOVERGENiHBG053151.
InParanoidiO75541.
OMAiCPLCQLE.
PhylomeDBiO75541.
TreeFamiTF326851.

Miscellaneous databases

GenomeRNAii55565.
NextBioi60048.
PROiO75541.

Gene expression databases

BgeeiO75541.
CleanExiHS_ZNF821.
ExpressionAtlasiO75541. baseline and differential.
GenevestigatoriO75541.

Family and domain databases

Gene3Di3.30.160.60. 1 hit.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 2 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Yu W., Gibbs R.A.
    Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Colon.
  3. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Uterus.

Entry informationi

Entry nameiZN821_HUMAN
AccessioniPrimary (citable) accession number: O75541
Secondary accession number(s): A6NK48, B4DKK4, D3DWS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 16, 2012
Last modified: February 4, 2015
This is version 129 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.