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O75541

- ZN821_HUMAN

UniProt

O75541 - ZN821_HUMAN

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Protein

Zinc finger protein 821

Gene

ZNF821

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri116 – 14025C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri150 – 17223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 821
Gene namesi
Name:ZNF821
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:28043. ZNF821.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162410689.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 412412Zinc finger protein 821PRO_0000317289Add
BLAST

Proteomic databases

PaxDbiO75541.
PRIDEiO75541.

PTM databases

PhosphoSiteiO75541.

Expressioni

Gene expression databases

BgeeiO75541.
CleanExiHS_ZNF821.
ExpressionAtlasiO75541. baseline and differential.
GenevestigatoriO75541.

Organism-specific databases

HPAiHPA036372.
HPA042742.

Interactioni

Protein-protein interaction databases

BioGridi120720. 2 interactions.
IntActiO75541. 2 interactions.
MINTiMINT-1442999.

Structurei

3D structure databases

ProteinModelPortaliO75541.
SMRiO75541. Positions 108-181.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili257 – 366110Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 2 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri116 – 14025C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri150 – 17223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG247293.
GeneTreeiENSGT00720000108795.
HOGENOMiHOG000069989.
HOVERGENiHBG053151.
InParanoidiO75541.
OMAiCPLCQLE.
PhylomeDBiO75541.
TreeFamiTF326851.

Family and domain databases

Gene3Di3.30.160.60. 1 hit.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 2 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O75541-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRRKQTNPN KVHWDQVFAG LEEQARQAMM KTDFPGDLGS QRQAIQQLRD
60 70 80 90 100
QDSSSSDSEG DEEETTQDEV SSHTSEEDGG VVKVEKELEN TEQPVGGNEV
110 120 130 140 150
VEHEVTGNLN SDPLLELCQC PLCQLDCGSR EQLIAHVYQH TAAVVSAKSY
160 170 180 190 200
MCPVCGRALS SPGSLGRHLL IHSEDQRSNC AVCGARFTSH ATFNSEKLPE
210 220 230 240 250
VLNMESLPTV HNEGPSSAEG KDIAFSPPVY PAGILLVCNN CAAYRKLLEA
260 270 280 290 300
QTPSVRKWAL RRQNEPLEVR LQRLERERTA KKSRRDNETP EEREVRRMRD
310 320 330 340 350
REAKRLQRMQ ETDEQRARRL QRDREAMRLK RANETPEKRQ ARLIREREAK
360 370 380 390 400
RLKRRLEKMD MMLRAQFGQD PSAMAALAAE MNFFQLPVSG VELDSQLLGK
410
MAFEEQNSSS LH

Note: No experimental confirmation available.

Length:412
Mass (Da):46,794
Last modified:May 16, 2012 - v3
Checksum:iB3C953147F1C4E5C
GO
Isoform 2 (identifier: O75541-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     16-57: Missing.

Show »
Length:370
Mass (Da):42,140
Checksum:i383D2D7EFAC1BEB5
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei16 – 5742Missing in isoform 2. 2 PublicationsVSP_030933Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF070588 mRNA. Translation: AAC28648.1.
AK296603 mRNA. Translation: BAG59216.1.
AC009127 Genomic DNA. No translation available.
AC010653 Genomic DNA. No translation available.
CH471166 Genomic DNA. Translation: EAW59211.1.
CH471166 Genomic DNA. Translation: EAW59213.1.
CH471166 Genomic DNA. Translation: EAW59214.1.
CH471166 Genomic DNA. Translation: EAW59219.1.
BC012116 mRNA. Translation: AAH12116.1.
CCDSiCCDS32481.1. [O75541-2]
CCDS56006.1. [O75541-1]
RefSeqiNP_001188481.1. NM_001201552.1. [O75541-1]
NP_001188482.1. NM_001201553.1. [O75541-1]
NP_001188483.1. NM_001201554.1.
NP_001188485.1. NM_001201556.1.
NP_060000.1. NM_017530.2.
XP_005256090.1. XM_005256033.1. [O75541-1]
XP_006721296.1. XM_006721233.1. [O75541-1]
UniGeneiHs.744055.

Genome annotation databases

EnsembliENST00000313565; ENSP00000313822; ENSG00000102984.
ENST00000425432; ENSP00000398089; ENSG00000102984. [O75541-1]
ENST00000446827; ENSP00000405908; ENSG00000102984.
ENST00000565601; ENSP00000455648; ENSG00000102984. [O75541-1]
GeneIDi55565.
KEGGihsa:55565.
UCSCiuc002fbe.3. human. [O75541-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF070588 mRNA. Translation: AAC28648.1 .
AK296603 mRNA. Translation: BAG59216.1 .
AC009127 Genomic DNA. No translation available.
AC010653 Genomic DNA. No translation available.
CH471166 Genomic DNA. Translation: EAW59211.1 .
CH471166 Genomic DNA. Translation: EAW59213.1 .
CH471166 Genomic DNA. Translation: EAW59214.1 .
CH471166 Genomic DNA. Translation: EAW59219.1 .
BC012116 mRNA. Translation: AAH12116.1 .
CCDSi CCDS32481.1. [O75541-2 ]
CCDS56006.1. [O75541-1 ]
RefSeqi NP_001188481.1. NM_001201552.1. [O75541-1 ]
NP_001188482.1. NM_001201553.1. [O75541-1 ]
NP_001188483.1. NM_001201554.1.
NP_001188485.1. NM_001201556.1.
NP_060000.1. NM_017530.2.
XP_005256090.1. XM_005256033.1. [O75541-1 ]
XP_006721296.1. XM_006721233.1. [O75541-1 ]
UniGenei Hs.744055.

3D structure databases

ProteinModelPortali O75541.
SMRi O75541. Positions 108-181.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120720. 2 interactions.
IntActi O75541. 2 interactions.
MINTi MINT-1442999.

PTM databases

PhosphoSitei O75541.

Proteomic databases

PaxDbi O75541.
PRIDEi O75541.

Protocols and materials databases

DNASUi 55565.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000313565 ; ENSP00000313822 ; ENSG00000102984 .
ENST00000425432 ; ENSP00000398089 ; ENSG00000102984 . [O75541-1 ]
ENST00000446827 ; ENSP00000405908 ; ENSG00000102984 .
ENST00000565601 ; ENSP00000455648 ; ENSG00000102984 . [O75541-1 ]
GeneIDi 55565.
KEGGi hsa:55565.
UCSCi uc002fbe.3. human. [O75541-1 ]

Organism-specific databases

CTDi 55565.
GeneCardsi GC16M071893.
HGNCi HGNC:28043. ZNF821.
HPAi HPA036372.
HPA042742.
neXtProti NX_O75541.
PharmGKBi PA162410689.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG247293.
GeneTreei ENSGT00720000108795.
HOGENOMi HOG000069989.
HOVERGENi HBG053151.
InParanoidi O75541.
OMAi CPLCQLE.
PhylomeDBi O75541.
TreeFami TF326851.

Miscellaneous databases

GenomeRNAii 55565.
NextBioi 60048.
PROi O75541.

Gene expression databases

Bgeei O75541.
CleanExi HS_ZNF821.
ExpressionAtlasi O75541. baseline and differential.
Genevestigatori O75541.

Family and domain databases

Gene3Di 3.30.160.60. 1 hit.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 2 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Yu W., Gibbs R.A.
    Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Colon.
  3. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Uterus.

Entry informationi

Entry nameiZN821_HUMAN
AccessioniPrimary (citable) accession number: O75541
Secondary accession number(s): A6NK48, B4DKK4, D3DWS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 16, 2012
Last modified: October 29, 2014
This is version 127 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3