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O75541

- ZN821_HUMAN

UniProt

O75541 - ZN821_HUMAN

Protein

Zinc finger protein 821

Gene

ZNF821

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
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    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 3 (16 May 2012)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri116 – 14025C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri150 – 17223C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 821
    Gene namesi
    Name:ZNF821
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:28043. ZNF821.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162410689.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 412412Zinc finger protein 821PRO_0000317289Add
    BLAST

    Proteomic databases

    PaxDbiO75541.
    PRIDEiO75541.

    PTM databases

    PhosphoSiteiO75541.

    Expressioni

    Gene expression databases

    ArrayExpressiO75541.
    BgeeiO75541.
    CleanExiHS_ZNF821.
    GenevestigatoriO75541.

    Organism-specific databases

    HPAiHPA036372.
    HPA042742.

    Interactioni

    Protein-protein interaction databases

    BioGridi120720. 2 interactions.
    IntActiO75541. 2 interactions.
    MINTiMINT-1442999.

    Structurei

    3D structure databases

    ProteinModelPortaliO75541.
    SMRiO75541. Positions 108-181.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili257 – 366110Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 2 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri116 – 14025C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri150 – 17223C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG247293.
    HOGENOMiHOG000069989.
    HOVERGENiHBG053151.
    InParanoidiO75541.
    OMAiCPLCQLE.
    PhylomeDBiO75541.
    TreeFamiTF326851.

    Family and domain databases

    Gene3Di3.30.160.60. 1 hit.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 2 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
    PS50157. ZINC_FINGER_C2H2_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O75541-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSRRKQTNPN KVHWDQVFAG LEEQARQAMM KTDFPGDLGS QRQAIQQLRD    50
    QDSSSSDSEG DEEETTQDEV SSHTSEEDGG VVKVEKELEN TEQPVGGNEV 100
    VEHEVTGNLN SDPLLELCQC PLCQLDCGSR EQLIAHVYQH TAAVVSAKSY 150
    MCPVCGRALS SPGSLGRHLL IHSEDQRSNC AVCGARFTSH ATFNSEKLPE 200
    VLNMESLPTV HNEGPSSAEG KDIAFSPPVY PAGILLVCNN CAAYRKLLEA 250
    QTPSVRKWAL RRQNEPLEVR LQRLERERTA KKSRRDNETP EEREVRRMRD 300
    REAKRLQRMQ ETDEQRARRL QRDREAMRLK RANETPEKRQ ARLIREREAK 350
    RLKRRLEKMD MMLRAQFGQD PSAMAALAAE MNFFQLPVSG VELDSQLLGK 400
    MAFEEQNSSS LH 412

    Note: No experimental confirmation available.

    Length:412
    Mass (Da):46,794
    Last modified:May 16, 2012 - v3
    Checksum:iB3C953147F1C4E5C
    GO
    Isoform 2 (identifier: O75541-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         16-57: Missing.

    Show »
    Length:370
    Mass (Da):42,140
    Checksum:i383D2D7EFAC1BEB5
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei16 – 5742Missing in isoform 2. 2 PublicationsVSP_030933Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF070588 mRNA. Translation: AAC28648.1.
    AK296603 mRNA. Translation: BAG59216.1.
    AC009127 Genomic DNA. No translation available.
    AC010653 Genomic DNA. No translation available.
    CH471166 Genomic DNA. Translation: EAW59211.1.
    CH471166 Genomic DNA. Translation: EAW59213.1.
    CH471166 Genomic DNA. Translation: EAW59214.1.
    CH471166 Genomic DNA. Translation: EAW59219.1.
    BC012116 mRNA. Translation: AAH12116.1.
    CCDSiCCDS32481.1. [O75541-2]
    CCDS56006.1. [O75541-1]
    RefSeqiNP_001188481.1. NM_001201552.1. [O75541-1]
    NP_001188482.1. NM_001201553.1. [O75541-1]
    NP_001188483.1. NM_001201554.1.
    NP_001188485.1. NM_001201556.1.
    NP_060000.1. NM_017530.2.
    XP_005256090.1. XM_005256033.1. [O75541-1]
    XP_006721296.1. XM_006721233.1. [O75541-1]
    UniGeneiHs.744055.

    Genome annotation databases

    EnsembliENST00000313565; ENSP00000313822; ENSG00000102984.
    ENST00000425432; ENSP00000398089; ENSG00000102984. [O75541-1]
    ENST00000446827; ENSP00000405908; ENSG00000102984.
    ENST00000565601; ENSP00000455648; ENSG00000102984. [O75541-1]
    GeneIDi55565.
    KEGGihsa:55565.
    UCSCiuc002fbe.3. human. [O75541-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF070588 mRNA. Translation: AAC28648.1 .
    AK296603 mRNA. Translation: BAG59216.1 .
    AC009127 Genomic DNA. No translation available.
    AC010653 Genomic DNA. No translation available.
    CH471166 Genomic DNA. Translation: EAW59211.1 .
    CH471166 Genomic DNA. Translation: EAW59213.1 .
    CH471166 Genomic DNA. Translation: EAW59214.1 .
    CH471166 Genomic DNA. Translation: EAW59219.1 .
    BC012116 mRNA. Translation: AAH12116.1 .
    CCDSi CCDS32481.1. [O75541-2 ]
    CCDS56006.1. [O75541-1 ]
    RefSeqi NP_001188481.1. NM_001201552.1. [O75541-1 ]
    NP_001188482.1. NM_001201553.1. [O75541-1 ]
    NP_001188483.1. NM_001201554.1.
    NP_001188485.1. NM_001201556.1.
    NP_060000.1. NM_017530.2.
    XP_005256090.1. XM_005256033.1. [O75541-1 ]
    XP_006721296.1. XM_006721233.1. [O75541-1 ]
    UniGenei Hs.744055.

    3D structure databases

    ProteinModelPortali O75541.
    SMRi O75541. Positions 108-181.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120720. 2 interactions.
    IntActi O75541. 2 interactions.
    MINTi MINT-1442999.

    PTM databases

    PhosphoSitei O75541.

    Proteomic databases

    PaxDbi O75541.
    PRIDEi O75541.

    Protocols and materials databases

    DNASUi 55565.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000313565 ; ENSP00000313822 ; ENSG00000102984 .
    ENST00000425432 ; ENSP00000398089 ; ENSG00000102984 . [O75541-1 ]
    ENST00000446827 ; ENSP00000405908 ; ENSG00000102984 .
    ENST00000565601 ; ENSP00000455648 ; ENSG00000102984 . [O75541-1 ]
    GeneIDi 55565.
    KEGGi hsa:55565.
    UCSCi uc002fbe.3. human. [O75541-1 ]

    Organism-specific databases

    CTDi 55565.
    GeneCardsi GC16M071893.
    HGNCi HGNC:28043. ZNF821.
    HPAi HPA036372.
    HPA042742.
    neXtProti NX_O75541.
    PharmGKBi PA162410689.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG247293.
    HOGENOMi HOG000069989.
    HOVERGENi HBG053151.
    InParanoidi O75541.
    OMAi CPLCQLE.
    PhylomeDBi O75541.
    TreeFami TF326851.

    Miscellaneous databases

    GenomeRNAii 55565.
    NextBioi 60048.
    PROi O75541.

    Gene expression databases

    ArrayExpressi O75541.
    Bgeei O75541.
    CleanExi HS_ZNF821.
    Genevestigatori O75541.

    Family and domain databases

    Gene3Di 3.30.160.60. 1 hit.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 2 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 2 hits.
    PS50157. ZINC_FINGER_C2H2_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Yu W., Gibbs R.A.
      Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Colon.
    3. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Uterus.

    Entry informationi

    Entry nameiZN821_HUMAN
    AccessioniPrimary (citable) accession number: O75541
    Secondary accession number(s): A6NK48, B4DKK4, D3DWS3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: May 16, 2012
    Last modified: October 1, 2014
    This is version 126 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3