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Protein

Splicing factor 3B subunit 1

Gene

SF3B1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron.

GO - Molecular functioni

  • mRNA binding Source: GO_Central
  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  • mRNA splicing, via spliceosome Source: UniProtKB
  • positive regulation of gene expression, epigenetic Source: Reactome
  • RNA splicing, via transesterification reactions Source: UniProtKB
  • spliceosomal complex assembly Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Enzyme and pathway databases

BioCyciZFISH:ENSG00000115524-MONOMER.
ReactomeiR-HSA-5250924. B-WICH complex positively regulates rRNA expression.
R-HSA-72163. mRNA Splicing - Major Pathway.
R-HSA-72165. mRNA Splicing - Minor Pathway.
SIGNORiO75533.

Names & Taxonomyi

Protein namesi
Recommended name:
Splicing factor 3B subunit 1
Alternative name(s):
Pre-mRNA-splicing factor SF3b 155 kDa subunit
Short name:
SF3b155
Spliceosome-associated protein 155
Short name:
SAP 155
Gene namesi
Name:SF3B1
Synonyms:SAP155
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:10768. SF3B1.

Subcellular locationi

  • Nucleus speckle

  • Note: During mitosis, transiently dispersed from the nuclear speckles to the cytoplasm.

GO - Cellular componenti

  • catalytic step 2 spliceosome Source: UniProtKB
  • nuclear speck Source: UniProtKB-SubCell
  • nucleoplasm Source: HPA
  • nucleus Source: MGI
  • spliceosomal complex Source: UniProtKB
  • U11/U12 snRNP Source: MGI
  • U12-type spliceosomal complex Source: UniProtKB
  • U2 snRNP Source: MGI
  • U2-type prespliceosome Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi200W → A: Abolishes interaction with RBM39; when associated with A-218; A-232; A-254; A-293; A-310 and A-338. 1 Publication1
Mutagenesisi218W → A: Abolishes interaction with RBM39; when associated with A-200; A-232; A-254; A-293; A-310 and A-338. 1 Publication1
Mutagenesisi223T → A: No effect on interaction with PPP1R8. 1 Publication1
Mutagenesisi227T → A: No effect on interaction with PPP1R8. 1 Publication1
Mutagenesisi232W → A: Abolishes interaction with RBM39; when associated with A-200; A-218; A-254; A-293; A-310 and A-338. 1 Publication1
Mutagenesisi235T → A: No effect on interaction with PPP1R8. 1 Publication1
Mutagenesisi244T → A: Slight inhibition of interaction with PPP1R8. 1 Publication1
Mutagenesisi248T → A: Slight inhibition of interaction with PPP1R8. 1 Publication1
Mutagenesisi254W → A: Abolishes interaction with RBM39; when associated with A-200; A-218; A-232; A-293; A-310 and A-338. 1 Publication1
Mutagenesisi257T → A: No effect on interaction with PPP1R8. 1 Publication1
Mutagenesisi261T → A: Slight inhibition of interaction with PPP1R8. 1 Publication1
Mutagenesisi267T → A: No effect on interaction with PPP1R8. 1 Publication1
Mutagenesisi273T → A: No effect on interaction with PPP1R8. 1 Publication1
Mutagenesisi278T → A: No effect on interaction with PPP1R8. 1 Publication1
Mutagenesisi293W → A: Abolishes interaction with RBM39; when associated with A-200; A-218; A-232; A-254; A-310 and A-338. 1 Publication1
Mutagenesisi296T → A: No effect on interaction with PPP1R8. 1 Publication1
Mutagenesisi303T → A: No effect on interaction with PPP1R8. 1 Publication1
Mutagenesisi310W → A: Abolishes interaction with RBM39; when associated with A-200; A-218; A-232; A-254; A-293 and A-338. 1 Publication1
Mutagenesisi313T → A: No effect on interaction with PPP1R8. 1 Publication1
Mutagenesisi338W → A: Abolishes interaction with RBM39; when associated with A-200; A-218; A-232; A-254; A-293 and A-310. 1 Publication1

Organism-specific databases

DisGeNETi23451.
MalaCardsiSF3B1.
OpenTargetsiENSG00000115524.
Orphaneti75564. Acquired idiopathic sideroblastic anemia.
PharmGKBiPA35686.

Polymorphism and mutation databases

BioMutaiSF3B1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001743231 – 1304Splicing factor 3B subunit 1Add BLAST1304

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei125PhosphothreonineCombined sources1
Modified residuei129PhosphoserineCombined sources1
Modified residuei141N6-acetyllysineCombined sources1
Modified residuei142PhosphothreonineCombined sources1
Modified residuei157CitrullineBy similarity1
Modified residuei194PhosphoserineCombined sources1
Modified residuei203PhosphothreonineCombined sources1
Modified residuei207PhosphothreonineCombined sources1
Modified residuei211PhosphothreonineCombined sources1
Modified residuei214N6-acetyllysineBy similarity1
Modified residuei223PhosphothreonineCombined sources1
Modified residuei227PhosphothreonineCombined sources1
Modified residuei229PhosphoserineBy similarity1
Modified residuei235PhosphothreonineCombined sources1
Modified residuei244Phosphothreonine1 Publication1
Modified residuei248Phosphothreonine1 Publication1
Modified residuei257PhosphothreonineCombined sources1
Modified residuei261PhosphothreonineCombined sources1
Modified residuei267PhosphothreonineCombined sources1
Modified residuei273PhosphothreonineCombined sources1
Modified residuei278PhosphothreonineCombined sources1
Modified residuei287PhosphoserineCombined sources1
Modified residuei296PhosphothreonineCombined sources1
Modified residuei299PhosphothreonineCombined sources1
Modified residuei303PhosphothreonineCombined sources1
Modified residuei313PhosphothreonineCombined sources1
Modified residuei322PhosphoserineCombined sources1
Modified residuei326PhosphothreonineCombined sources1
Modified residuei328PhosphothreonineCombined sources1
Modified residuei332PhosphoserineCombined sources1
Modified residuei341PhosphothreonineCombined sources1
Modified residuei344PhosphoserineCombined sources1
Modified residuei349PhosphoserineCombined sources1
Modified residuei350PhosphothreonineCombined sources1
Modified residuei354PhosphothreonineCombined sources1
Modified residuei400PhosphoserineCombined sources1
Cross-linki413Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Cross-linki413Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei426PhosphothreonineCombined sources1
Modified residuei434PhosphothreonineCombined sources1
Modified residuei436PhosphothreonineCombined sources1
Modified residuei488PhosphoserineCombined sources1
Modified residuei554N6-acetyllysineCombined sources1
Modified residuei562N6-acetyllysineCombined sources1

Post-translational modificationi

Phosphorylated. Phosphorylation occurs concomitantly with the splicing catalytic steps. Phosphorylation on Thr-244, Thr-248 and Thr-313 by cyclin-dependent kinases promotes interaction with PPP1R8 during mitosis.2 Publications
Citrullinated by PADI4.By similarity

Keywords - PTMi

Acetylation, Citrullination, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO75533.
MaxQBiO75533.
PaxDbiO75533.
PeptideAtlasiO75533.
PRIDEiO75533.

PTM databases

iPTMnetiO75533.
PhosphoSitePlusiO75533.
SwissPalmiO75533.

Miscellaneous databases

PMAP-CutDBO75533.

Expressioni

Gene expression databases

BgeeiENSG00000115524.
CleanExiHS_SF3B1.
ExpressionAtlasiO75533. baseline and differential.
GenevisibleiO75533. HS.

Organism-specific databases

HPAiHPA050275.

Interactioni

Subunit structurei

Interacts with SETX (PubMed:21700224). Identified in the spliceosome C complex. Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Component of splicing factor SF3B which is composed of at least eight subunits; SF3B1/SAP155/SF3B155, SF3B2/SAP145/SF3B155, SF3B3/SAP130/SF3B130, SF3B4/SAP49/SF3B49, SF3B5, SF3B6, PHF5A/SF3B14B, and DDX42. Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21. SF3B associates with the splicing factor SF3A and a 12S RNA unit to form the U2 small nuclear ribonucleoproteins complex (U2 snRNP). SF3B1 interacts directly with the splicing factor U2AF. Phosphorylated form interacts with PPP1R8. Interacts with PQBP1. Interacts with RBM17. Interacts with RBM39. Interacts with SF3B6 (PubMed:11991638, PubMed:12105215, PubMed:12234937, PubMed:12738865, PubMed:15146077, PubMed:16432215, PubMed:16603771, PubMed:17589525, PubMed:21062891, PubMed:23512658, PubMed:24795046).12 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
RBM17Q96I252EBI-876542,EBI-740272

Protein-protein interaction databases

BioGridi117017. 193 interactors.
DIPiDIP-29411N.
IntActiO75533. 62 interactors.
MINTiMINT-1185911.
STRINGi9606.ENSP00000335321.

Structurei

Secondary structure

11304
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi380 – 394Combined sources15
Helixi401 – 406Combined sources6
Beta strandi410 – 414Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2F9DX-ray2.50P/Q373-415[»]
2F9JX-ray3.00P/Q380-415[»]
2FHONMR-A379-424[»]
2PEHX-ray2.11C/D333-342[»]
3LQVX-ray2.38P/Q377-415[»]
4OZ1X-ray1.74C333-342[»]
ProteinModelPortaliO75533.
SMRiO75533.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO75533.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati529 – 568HEAT 1Add BLAST40
Repeati569 – 603HEAT 2Add BLAST35
Repeati604 – 641HEAT 3Add BLAST38
Repeati643 – 677HEAT 4Add BLAST35
Repeati680 – 718HEAT 5Add BLAST39
Repeati763 – 801HEAT 6Add BLAST39
Repeati843 – 881HEAT 7Add BLAST39
Repeati1010 – 1048HEAT 8Add BLAST39
Repeati1052 – 1090HEAT 9Add BLAST39
Repeati1122 – 1160HEAT 10Add BLAST39
Repeati1163 – 1201HEAT 11Add BLAST39

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni190 – 342U2AF homology region; mediates interaction with RBM391 PublicationAdd BLAST153
Regioni223 – 491Interaction with PPP1R81 PublicationAdd BLAST269
Regioni529 – 568Interaction with SF3B14Add BLAST40

Sequence similaritiesi

Belongs to the SF3B1 family.Curated
Contains 11 HEAT repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0213. Eukaryota.
COG5181. LUCA.
GeneTreeiENSGT00390000018393.
HOGENOMiHOG000166737.
HOVERGENiHBG079173.
InParanoidiO75533.
KOiK12828.
OMAiKGRYEGY.
OrthoDBiEOG091G00Q0.
PhylomeDBiO75533.
TreeFamiTF105680.

Family and domain databases

Gene3Di1.25.10.10. 4 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR015016. SF3b_su1.
[Graphical view]
PfamiPF08920. SF3b1. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75533-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAKIAKTHED IEAQIREIQG KKAALDEAQG VGLDSTGYYD QEIYGGSDSR
60 70 80 90 100
FAGYVTSIAA TELEDDDDDY SSSTSLLGQK KPGYHAPVAL LNDIPQSTEQ
110 120 130 140 150
YDPFAEHRPP KIADREDEYK KHRRTMIISP ERLDPFADGG KTPDPKMNAR
160 170 180 190 200
TYMDVMREQH LTKEEREIRQ QLAEKAKAGE LKVVNGAAAS QPPSKRKRRW
210 220 230 240 250
DQTADQTPGA TPKKLSSWDQ AETPGHTPSL RWDETPGRAK GSETPGATPG
260 270 280 290 300
SKIWDPTPSH TPAGAATPGR GDTPGHATPG HGGATSSARK NRWDETPKTE
310 320 330 340 350
RDTPGHGSGW AETPRTDRGG DSIGETPTPG ASKRKSRWDE TPASQMGGST
360 370 380 390 400
PVLTPGKTPI GTPAMNMATP TPGHIMSMTP EQLQAWRWER EIDERNRPLS
410 420 430 440 450
DEELDAMFPE GYKVLPPPAG YVPIRTPARK LTATPTPLGG MTGFHMQTED
460 470 480 490 500
RTMKSVNDQP SGNLPFLKPD DIQYFDKLLV DVDESTLSPE EQKERKIMKL
510 520 530 540 550
LLKIKNGTPP MRKAALRQIT DKAREFGAGP LFNQILPLLM SPTLEDQERH
560 570 580 590 600
LLVKVIDRIL YKLDDLVRPY VHKILVVIEP LLIDEDYYAR VEGREIISNL
610 620 630 640 650
AKAAGLATMI STMRPDIDNM DEYVRNTTAR AFAVVASALG IPSLLPFLKA
660 670 680 690 700
VCKSKKSWQA RHTGIKIVQQ IAILMGCAIL PHLRSLVEII EHGLVDEQQK
710 720 730 740 750
VRTISALAIA ALAEAATPYG IESFDSVLKP LWKGIRQHRG KGLAAFLKAI
760 770 780 790 800
GYLIPLMDAE YANYYTREVM LILIREFQSP DEEMKKIVLK VVKQCCGTDG
810 820 830 840 850
VEANYIKTEI LPPFFKHFWQ HRMALDRRNY RQLVDTTVEL ANKVGAAEII
860 870 880 890 900
SRIVDDLKDE AEQYRKMVME TIEKIMGNLG AADIDHKLEE QLIDGILYAF
910 920 930 940 950
QEQTTEDSVM LNGFGTVVNA LGKRVKPYLP QICGTVLWRL NNKSAKVRQQ
960 970 980 990 1000
AADLISRTAV VMKTCQEEKL MGHLGVVLYE YLGEEYPEVL GSILGALKAI
1010 1020 1030 1040 1050
VNVIGMHKMT PPIKDLLPRL TPILKNRHEK VQENCIDLVG RIADRGAEYV
1060 1070 1080 1090 1100
SAREWMRICF ELLELLKAHK KAIRRATVNT FGYIAKAIGP HDVLATLLNN
1110 1120 1130 1140 1150
LKVQERQNRV CTTVAIAIVA ETCSPFTVLP ALMNEYRVPE LNVQNGVLKS
1160 1170 1180 1190 1200
LSFLFEYIGE MGKDYIYAVT PLLEDALMDR DLVHRQTASA VVQHMSLGVY
1210 1220 1230 1240 1250
GFGCEDSLNH LLNYVWPNVF ETSPHVIQAV MGALEGLRVA IGPCRMLQYC
1260 1270 1280 1290 1300
LQGLFHPARK VRDVYWKIYN SIYIGSQDAL IAHYPRIYND DKNTYIRYEL

DYIL
Length:1,304
Mass (Da):145,830
Last modified:November 24, 2009 - v3
Checksum:i12F051757D2B9DEE
GO
Isoform 2 (identifier: O75533-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     140-144: GKTPD → FYSAA
     145-1304: Missing.

Note: No experimental confirmation available.
Show »
Length:144
Mass (Da):16,020
Checksum:i006D4294E06AB51E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti149A → V in AAC97189 (PubMed:9585501).Curated1
Sequence conflicti594R → L in AAC97189 (PubMed:9585501).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_046182140 – 144GKTPD → FYSAA in isoform 2. 1 Publication5
Alternative sequenceiVSP_046183145 – 1304Missing in isoform 2. 1 PublicationAdd BLAST1160

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF054284 mRNA. Translation: AAC97189.1.
AF086296 mRNA. No translation available.
AC010746 Genomic DNA. No translation available.
AF070540 mRNA. Translation: AAC28633.1.
CCDSiCCDS33356.1. [O75533-1]
CCDS46479.1. [O75533-2]
RefSeqiNP_036565.2. NM_012433.3. [O75533-1]
UniGeneiHs.632554.

Genome annotation databases

EnsembliENST00000335508; ENSP00000335321; ENSG00000115524. [O75533-1]
ENST00000409915; ENSP00000428820; ENSG00000115524. [O75533-2]
ENST00000414963; ENSP00000402997; ENSG00000115524. [O75533-2]
GeneIDi23451.
KEGGihsa:23451.
UCSCiuc002uue.4. human. [O75533-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF054284 mRNA. Translation: AAC97189.1.
AF086296 mRNA. No translation available.
AC010746 Genomic DNA. No translation available.
AF070540 mRNA. Translation: AAC28633.1.
CCDSiCCDS33356.1. [O75533-1]
CCDS46479.1. [O75533-2]
RefSeqiNP_036565.2. NM_012433.3. [O75533-1]
UniGeneiHs.632554.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2F9DX-ray2.50P/Q373-415[»]
2F9JX-ray3.00P/Q380-415[»]
2FHONMR-A379-424[»]
2PEHX-ray2.11C/D333-342[»]
3LQVX-ray2.38P/Q377-415[»]
4OZ1X-ray1.74C333-342[»]
ProteinModelPortaliO75533.
SMRiO75533.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117017. 193 interactors.
DIPiDIP-29411N.
IntActiO75533. 62 interactors.
MINTiMINT-1185911.
STRINGi9606.ENSP00000335321.

PTM databases

iPTMnetiO75533.
PhosphoSitePlusiO75533.
SwissPalmiO75533.

Polymorphism and mutation databases

BioMutaiSF3B1.

Proteomic databases

EPDiO75533.
MaxQBiO75533.
PaxDbiO75533.
PeptideAtlasiO75533.
PRIDEiO75533.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335508; ENSP00000335321; ENSG00000115524. [O75533-1]
ENST00000409915; ENSP00000428820; ENSG00000115524. [O75533-2]
ENST00000414963; ENSP00000402997; ENSG00000115524. [O75533-2]
GeneIDi23451.
KEGGihsa:23451.
UCSCiuc002uue.4. human. [O75533-1]

Organism-specific databases

CTDi23451.
DisGeNETi23451.
GeneCardsiSF3B1.
HGNCiHGNC:10768. SF3B1.
HPAiHPA050275.
MalaCardsiSF3B1.
MIMi605590. gene.
neXtProtiNX_O75533.
OpenTargetsiENSG00000115524.
Orphaneti75564. Acquired idiopathic sideroblastic anemia.
PharmGKBiPA35686.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0213. Eukaryota.
COG5181. LUCA.
GeneTreeiENSGT00390000018393.
HOGENOMiHOG000166737.
HOVERGENiHBG079173.
InParanoidiO75533.
KOiK12828.
OMAiKGRYEGY.
OrthoDBiEOG091G00Q0.
PhylomeDBiO75533.
TreeFamiTF105680.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000115524-MONOMER.
ReactomeiR-HSA-5250924. B-WICH complex positively regulates rRNA expression.
R-HSA-72163. mRNA Splicing - Major Pathway.
R-HSA-72165. mRNA Splicing - Minor Pathway.
SIGNORiO75533.

Miscellaneous databases

ChiTaRSiSF3B1. human.
EvolutionaryTraceiO75533.
GeneWikiiSF3B1.
GenomeRNAii23451.
PMAP-CutDBO75533.
PROiO75533.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000115524.
CleanExiHS_SF3B1.
ExpressionAtlasiO75533. baseline and differential.
GenevisibleiO75533. HS.

Family and domain databases

Gene3Di1.25.10.10. 4 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR015016. SF3b_su1.
[Graphical view]
PfamiPF08920. SF3b1. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiSF3B1_HUMAN
AccessioniPrimary (citable) accession number: O75533
Secondary accession number(s): E9PCH3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: November 24, 2009
Last modified: November 2, 2016
This is version 165 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.