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Protein

TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L

Gene

TAF5L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex.

GO - Molecular functioni

  • DNA binding transcription factor activity Source: ProtInc
  • transcription coactivator activity Source: UniProtKB

GO - Biological processi

  • histone H3 acetylation Source: UniProtKB
  • transcription by RNA polymerase II Source: ProtInc

Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-3214847 HATs acetylate histones
SignaLinkiO75529

Names & Taxonomyi

Protein namesi
Recommended name:
TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L
Alternative name(s):
PCAF-associated factor 65 beta
Short name:
PAF65-beta
Gene namesi
Name:TAF5L
Synonyms:PAF65B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000135801.9
HGNCiHGNC:17304 TAF5L
neXtProtiNX_O75529

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi27097
OpenTargetsiENSG00000135801
PharmGKBiPA38223

Polymorphism and mutation databases

BioMutaiTAF5L

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000512611 – 589TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5LAdd BLAST589

Proteomic databases

EPDiO75529
MaxQBiO75529
PaxDbiO75529
PeptideAtlasiO75529
PRIDEiO75529

PTM databases

iPTMnetiO75529
PhosphoSitePlusiO75529

Expressioni

Gene expression databases

BgeeiENSG00000135801
CleanExiHS_TAF5L
ExpressionAtlasiO75529 baseline and differential
GenevisibleiO75529 HS

Organism-specific databases

HPAiHPA067941

Interactioni

Subunit structurei

The PCAF complex is composed of a number of TBP-associated factors (TAFS), such as TAF5, TAF5L, TAF6, TAF6L, TAF9, TAF10 and TAF12, PCAF, and also PCAF-associated factors (PAFs), such as TADA2L/ADA2, TADA3L/ADA3 and SPT3. Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
FOXO3O435242EBI-1785876,EBI-1644164

Protein-protein interaction databases

BioGridi117998, 44 interactors
CORUMiO75529
DIPiDIP-28147N
IntActiO75529, 12 interactors
MINTiO75529
STRINGi9606.ENSP00000258281

Structurei

3D structure databases

ProteinModelPortaliO75529
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati266 – 305WD 1Add BLAST40
Repeati340 – 379WD 2Add BLAST40
Repeati382 – 421WD 3Add BLAST40
Repeati424 – 463WD 4Add BLAST40
Repeati466 – 505WD 5Add BLAST40
Repeati508 – 547WD 6Add BLAST40

Sequence similaritiesi

Belongs to the WD repeat TAF5 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0263 Eukaryota
ENOG410XPM5 LUCA
GeneTreeiENSGT00910000144058
HOGENOMiHOG000212423
HOVERGENiHBG050226
InParanoidiO75529
KOiK03130
OMAiYCNAPAD
OrthoDBiEOG091G03SP
PhylomeDBiO75529
TreeFamiTF300669

Family and domain databases

CDDicd08044 TAF5_NTD2, 1 hit
Gene3Di1.25.40.500, 1 hit
2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR037826 TAF5L
IPR007582 TFIID_NTD2
IPR037264 TFIID_NTD2_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR19879:SF6 PTHR19879:SF6, 1 hit
PfamiView protein in Pfam
PF04494 TFIID_NTD2, 1 hit
PF00400 WD40, 5 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 6 hits
SUPFAMiSSF160897 SSF160897, 1 hit
SSF50978 SSF50978, 2 hits
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 6 hits
PS50294 WD_REPEATS_REGION, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75529-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKRVRTEQIQ MAVSCYLKRR QYVDSDGPLK QGLRLSQTAE EMAANLTVQS
60 70 80 90 100
ESGCANIVSA APCQAEPQQY EVQFGRLRNF LTDSDSQHSH EVMPLLYPLF
110 120 130 140 150
VYLHLNLVQN SPKSTVESFY SRFHGMFLQN ASQKDVIEQL QTTQTIQDIL
160 170 180 190 200
SNFKLRAFLD NKYVVRLQED SYNYLIRYLQ SDNNTALCKV LTLHIHLDVQ
210 220 230 240 250
PAKRTDYQLY ASGSSSRSEN NGLEPPDMPS PILQNEAALE VLQESIKRVK
260 270 280 290 300
DGPPSLTTIC FYAFYNTEQL LNTAEISPDS KLLAAGFDNS CIKLWSLRSK
310 320 330 340 350
KLKSEPHQVD VSRIHLACDI LEEEDDEDDN AGTEMKILRG HCGPVYSTRF
360 370 380 390 400
LADSSGLLSC SEDMSIRYWD LGSFTNTVLY QGHAYPVWDL DISPYSLYFA
410 420 430 440 450
SGSHDRTARL WSFDRTYPLR IYAGHLADVD CVKFHPNSNY LATGSTDKTV
460 470 480 490 500
RLWSAQQGNS VRLFTGHRGP VLSLAFSPNG KYLASAGEDQ RLKLWDLASG
510 520 530 540 550
TLYKELRGHT DNITSLTFSP DSGLIASASM DNSVRVWDIR NTYCSAPADG
560 570 580
SSSELVGVYT GQMSNVLSVQ FMACNLLLVT GITQENQEH
Length:589
Mass (Da):66,155
Last modified:November 1, 1998 - v1
Checksum:iBBF0A1CDD17EE22E
GO
Isoform 2 (identifier: O75529-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     325-325: D → V
     326-589: Missing.

Note: May be due to an intron retention. No experimental confirmation available.
Show »
Length:325
Mass (Da):36,991
Checksum:i509F5DFEF8BE696B
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010156325D → V in isoform 2. 1 Publication1
Alternative sequenceiVSP_010157326 – 589Missing in isoform 2. 1 PublicationAdd BLAST264

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF069736 mRNA Translation: AAC39906.1
AL121990 Genomic DNA No translation available.
CH471098 Genomic DNA Translation: EAW69902.1
CH471098 Genomic DNA Translation: EAW69903.1
BC041094 mRNA Translation: AAH41094.1
AJ009770 mRNA Translation: CAA08816.1
CCDSiCCDS1581.1 [O75529-1]
CCDS31051.1 [O75529-2]
RefSeqiNP_001020418.1, NM_001025247.1 [O75529-2]
NP_055224.1, NM_014409.3 [O75529-1]
XP_005273156.1, XM_005273099.4 [O75529-1]
UniGeneiHs.270621

Genome annotation databases

EnsembliENST00000258281; ENSP00000258281; ENSG00000135801 [O75529-1]
ENST00000366675; ENSP00000355635; ENSG00000135801 [O75529-2]
ENST00000366676; ENSP00000355636; ENSG00000135801 [O75529-1]
GeneIDi27097
KEGGihsa:27097
UCSCiuc001htq.5 human [O75529-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTAF5L_HUMAN
AccessioniPrimary (citable) accession number: O75529
Secondary accession number(s): Q5TDI5, Q5TDI6, Q8IW31
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: November 1, 1998
Last modified: March 28, 2018
This is version 165 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health