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Protein

TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L

Gene

TAF5L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex.

GO - Molecular functioni

  • transcription coactivator activity Source: UniProtKB
  • transcription factor activity, sequence-specific DNA binding Source: ProtInc

GO - Biological processi

  • histone H3 acetylation Source: UniProtKB
  • transcription from RNA polymerase II promoter Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135801-MONOMER.
ReactomeiR-HSA-3214847. HATs acetylate histones.
SignaLinkiO75529.

Names & Taxonomyi

Protein namesi
Recommended name:
TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L
Alternative name(s):
PCAF-associated factor 65 beta
Short name:
PAF65-beta
Gene namesi
Name:TAF5L
Synonyms:PAF65B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:17304. TAF5L.

Subcellular locationi

GO - Cellular componenti

  • STAGA complex Source: UniProtKB
  • transcription factor TFTC complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi27097.
OpenTargetsiENSG00000135801.
PharmGKBiPA38223.

Polymorphism and mutation databases

BioMutaiTAF5L.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000512611 – 589TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5LAdd BLAST589

Proteomic databases

EPDiO75529.
MaxQBiO75529.
PaxDbiO75529.
PeptideAtlasiO75529.
PRIDEiO75529.

PTM databases

iPTMnetiO75529.
PhosphoSitePlusiO75529.

Expressioni

Gene expression databases

BgeeiENSG00000135801.
CleanExiHS_TAF5L.
ExpressionAtlasiO75529. baseline and differential.
GenevisibleiO75529. HS.

Organism-specific databases

HPAiCAB025973.

Interactioni

Subunit structurei

The PCAF complex is composed of a number of TBP-associated factors (TAFS), such as TAF5, TAF5L, TAF6, TAF6L, TAF9, TAF10 and TAF12, PCAF, and also PCAF-associated factors (PAFs), such as TADA2L/ADA2, TADA3L/ADA3 and SPT3. Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
FOXO3O435242EBI-1785876,EBI-1644164

Protein-protein interaction databases

BioGridi117998. 35 interactors.
DIPiDIP-28147N.
IntActiO75529. 11 interactors.
MINTiMINT-7944830.
STRINGi9606.ENSP00000258281.

Structurei

3D structure databases

ProteinModelPortaliO75529.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati266 – 305WD 1Add BLAST40
Repeati340 – 379WD 2Add BLAST40
Repeati382 – 421WD 3Add BLAST40
Repeati424 – 463WD 4Add BLAST40
Repeati466 – 505WD 5Add BLAST40
Repeati508 – 547WD 6Add BLAST40

Sequence similaritiesi

Belongs to the WD repeat TAF5 family.Curated
Contains 6 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0263. Eukaryota.
ENOG410XPM5. LUCA.
GeneTreeiENSGT00860000133707.
HOGENOMiHOG000212423.
HOVERGENiHBG050226.
InParanoidiO75529.
KOiK03130.
OMAiIQYAVAQ.
OrthoDBiEOG091G03SP.
PhylomeDBiO75529.
TreeFamiTF300669.

Family and domain databases

CDDicd08044. TAF5_NTD2. 1 hit.
Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR007582. TFIID_NTD2.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF04494. TFIID_NTD2. 1 hit.
PF00400. WD40. 5 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75529-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKRVRTEQIQ MAVSCYLKRR QYVDSDGPLK QGLRLSQTAE EMAANLTVQS
60 70 80 90 100
ESGCANIVSA APCQAEPQQY EVQFGRLRNF LTDSDSQHSH EVMPLLYPLF
110 120 130 140 150
VYLHLNLVQN SPKSTVESFY SRFHGMFLQN ASQKDVIEQL QTTQTIQDIL
160 170 180 190 200
SNFKLRAFLD NKYVVRLQED SYNYLIRYLQ SDNNTALCKV LTLHIHLDVQ
210 220 230 240 250
PAKRTDYQLY ASGSSSRSEN NGLEPPDMPS PILQNEAALE VLQESIKRVK
260 270 280 290 300
DGPPSLTTIC FYAFYNTEQL LNTAEISPDS KLLAAGFDNS CIKLWSLRSK
310 320 330 340 350
KLKSEPHQVD VSRIHLACDI LEEEDDEDDN AGTEMKILRG HCGPVYSTRF
360 370 380 390 400
LADSSGLLSC SEDMSIRYWD LGSFTNTVLY QGHAYPVWDL DISPYSLYFA
410 420 430 440 450
SGSHDRTARL WSFDRTYPLR IYAGHLADVD CVKFHPNSNY LATGSTDKTV
460 470 480 490 500
RLWSAQQGNS VRLFTGHRGP VLSLAFSPNG KYLASAGEDQ RLKLWDLASG
510 520 530 540 550
TLYKELRGHT DNITSLTFSP DSGLIASASM DNSVRVWDIR NTYCSAPADG
560 570 580
SSSELVGVYT GQMSNVLSVQ FMACNLLLVT GITQENQEH
Length:589
Mass (Da):66,155
Last modified:November 1, 1998 - v1
Checksum:iBBF0A1CDD17EE22E
GO
Isoform 2 (identifier: O75529-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     325-325: D → V
     326-589: Missing.

Note: May be due to an intron retention. No experimental confirmation available.
Show »
Length:325
Mass (Da):36,991
Checksum:i509F5DFEF8BE696B
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010156325D → V in isoform 2. 1 Publication1
Alternative sequenceiVSP_010157326 – 589Missing in isoform 2. 1 PublicationAdd BLAST264

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF069736 mRNA. Translation: AAC39906.1.
AL121990 Genomic DNA. Translation: CAI22015.1.
AL121990 Genomic DNA. Translation: CAI22016.1.
CH471098 Genomic DNA. Translation: EAW69902.1.
CH471098 Genomic DNA. Translation: EAW69903.1.
BC041094 mRNA. Translation: AAH41094.1.
AJ009770 mRNA. Translation: CAA08816.1.
CCDSiCCDS1581.1. [O75529-1]
CCDS31051.1. [O75529-2]
RefSeqiNP_001020418.1. NM_001025247.1. [O75529-2]
NP_055224.1. NM_014409.3. [O75529-1]
XP_005273156.1. XM_005273099.4. [O75529-1]
UniGeneiHs.270621.

Genome annotation databases

EnsembliENST00000258281; ENSP00000258281; ENSG00000135801. [O75529-1]
ENST00000366675; ENSP00000355635; ENSG00000135801. [O75529-2]
ENST00000366676; ENSP00000355636; ENSG00000135801. [O75529-1]
GeneIDi27097.
KEGGihsa:27097.
UCSCiuc001htq.5. human. [O75529-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF069736 mRNA. Translation: AAC39906.1.
AL121990 Genomic DNA. Translation: CAI22015.1.
AL121990 Genomic DNA. Translation: CAI22016.1.
CH471098 Genomic DNA. Translation: EAW69902.1.
CH471098 Genomic DNA. Translation: EAW69903.1.
BC041094 mRNA. Translation: AAH41094.1.
AJ009770 mRNA. Translation: CAA08816.1.
CCDSiCCDS1581.1. [O75529-1]
CCDS31051.1. [O75529-2]
RefSeqiNP_001020418.1. NM_001025247.1. [O75529-2]
NP_055224.1. NM_014409.3. [O75529-1]
XP_005273156.1. XM_005273099.4. [O75529-1]
UniGeneiHs.270621.

3D structure databases

ProteinModelPortaliO75529.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117998. 35 interactors.
DIPiDIP-28147N.
IntActiO75529. 11 interactors.
MINTiMINT-7944830.
STRINGi9606.ENSP00000258281.

PTM databases

iPTMnetiO75529.
PhosphoSitePlusiO75529.

Polymorphism and mutation databases

BioMutaiTAF5L.

Proteomic databases

EPDiO75529.
MaxQBiO75529.
PaxDbiO75529.
PeptideAtlasiO75529.
PRIDEiO75529.

Protocols and materials databases

DNASUi27097.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258281; ENSP00000258281; ENSG00000135801. [O75529-1]
ENST00000366675; ENSP00000355635; ENSG00000135801. [O75529-2]
ENST00000366676; ENSP00000355636; ENSG00000135801. [O75529-1]
GeneIDi27097.
KEGGihsa:27097.
UCSCiuc001htq.5. human. [O75529-1]

Organism-specific databases

CTDi27097.
DisGeNETi27097.
GeneCardsiTAF5L.
HGNCiHGNC:17304. TAF5L.
HPAiCAB025973.
neXtProtiNX_O75529.
OpenTargetsiENSG00000135801.
PharmGKBiPA38223.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0263. Eukaryota.
ENOG410XPM5. LUCA.
GeneTreeiENSGT00860000133707.
HOGENOMiHOG000212423.
HOVERGENiHBG050226.
InParanoidiO75529.
KOiK03130.
OMAiIQYAVAQ.
OrthoDBiEOG091G03SP.
PhylomeDBiO75529.
TreeFamiTF300669.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135801-MONOMER.
ReactomeiR-HSA-3214847. HATs acetylate histones.
SignaLinkiO75529.

Miscellaneous databases

ChiTaRSiTAF5L. human.
GeneWikiiTAF5L.
GenomeRNAii27097.
PROiO75529.

Gene expression databases

BgeeiENSG00000135801.
CleanExiHS_TAF5L.
ExpressionAtlasiO75529. baseline and differential.
GenevisibleiO75529. HS.

Family and domain databases

CDDicd08044. TAF5_NTD2. 1 hit.
Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR007582. TFIID_NTD2.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF04494. TFIID_NTD2. 1 hit.
PF00400. WD40. 5 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTAF5L_HUMAN
AccessioniPrimary (citable) accession number: O75529
Secondary accession number(s): Q5TDI5, Q5TDI6, Q8IW31
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 151 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.