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O75528

- TADA3_HUMAN

UniProt

O75528 - TADA3_HUMAN

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Protein

Transcriptional adapter 3

Gene

TADA3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. Also known as a coactivator for p53/TP53-dependent transcriptional activation. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.2 Publications

GO - Molecular functioni

  1. ligand-dependent nuclear receptor binding Source: UniProtKB
  2. ligand-dependent nuclear receptor transcription coactivator activity Source: Ensembl
  3. protein domain specific binding Source: UniProtKB
  4. sequence-specific DNA binding transcription factor activity Source: ProtInc
  5. transcription coactivator activity Source: UniProtKB

GO - Biological processi

  1. chromatin organization Source: Reactome
  2. histone H3 acetylation Source: UniProtKB
  3. intracellular estrogen receptor signaling pathway Source: UniProtKB
  4. mitotic nuclear division Source: Ensembl
  5. positive regulation of gene expression Source: UniProtKB
  6. positive regulation of transcription, DNA-templated Source: UniProtKB
  7. regulation of histone deacetylation Source: Ensembl
  8. regulation of protein phosphorylation Source: Ensembl
  9. regulation of protein stability Source: Ensembl
  10. regulation of transcription from RNA polymerase II promoter Source: ProtInc
  11. regulation of tubulin deacetylation Source: Ensembl
  12. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiREACT_172610. HATs acetylate histones.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional adapter 3
Alternative name(s):
ADA3 homolog
Short name:
hADA3
STAF54
Transcriptional adapter 3-like
Short name:
ADA3-like protein
Gene namesi
Name:TADA3
Synonyms:ADA3, TADA3L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:19422. TADA3.

Subcellular locationi

Nucleus 2 Publications

GO - Cellular componenti

  1. Ada2/Gcn5/Ada3 transcription activator complex Source: BHF-UCL
  2. intracellular Source: LIFEdb
  3. mitotic spindle Source: Ensembl
  4. nucleus Source: HPA
  5. STAGA complex Source: UniProtKB
  6. transcription factor TFTC complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165698494.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 432432Transcriptional adapter 3PRO_0000072416Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei418 – 4181N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiO75528.
PaxDbiO75528.
PRIDEiO75528.

PTM databases

PhosphoSiteiO75528.

Expressioni

Tissue specificityi

Ubiquitously expressed.

Gene expression databases

BgeeiO75528.
CleanExiHS_TADA3L.
ExpressionAtlasiO75528. baseline and differential.
GenevestigatoriO75528.

Organism-specific databases

HPAiHPA042250.

Interactioni

Subunit structurei

The PCAF complex is composed of a number of TBP-associated factors (TAFS), such as TAF5, TAF5L, TAF6, TAF6L, TAF9, TAF10 and TAF12, PCAF, and also PCAF-associated factors (PAFs), such as TADA2L/ADA2, TADA3L/ADA3 and SPT3. Interacts directly with TADA2L and PCAF and also with the high-risk HPV oncoprotein E6. Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9. Component of the TFTC-HAT complex. Component of the ADA2A-containing complex (ATAC), composed of CSRP2BP, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1.6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PIAS4Q8N2W92EBI-473249,EBI-473160
USP5P459742EBI-473249,EBI-741277

Protein-protein interaction databases

BioGridi115737. 57 interactions.
IntActiO75528. 19 interactions.
MINTiMINT-221730.
STRINGi9606.ENSP00000307684.

Structurei

3D structure databases

ProteinModelPortaliO75528.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili40 – 6930Sequence AnalysisAdd
BLAST
Coiled coili367 – 40741Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the NGG1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG265778.
GeneTreeiENSGT00390000008947.
HOGENOMiHOG000007362.
HOVERGENiHBG055283.
InParanoidiO75528.
KOiK11315.
OMAiQDKKGDK.
OrthoDBiEOG79PJP8.
PhylomeDBiO75528.
TreeFamiTF323397.

Family and domain databases

InterProiIPR019340. Histone_AcTrfase_su3.
[Graphical view]
PfamiPF10198. Ada3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O75528-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSELKDCPLQ FHDFKSVDHL KVCPRYTAVL ARSEDDGIGI EELDTLQLEL
60 70 80 90 100
ETLLSSASRR LRVLEAETQI LTDWQDKKGD RRFLKLGRDH ELGAPPKHGK
110 120 130 140 150
PKKQKLEGKA GHGPGPGPGR PKSKNLQPKI QEYEFTDDPI DVPRIPKNDA
160 170 180 190 200
PNRFWASVEP YCADITSEEV RTLEELLKPP EDEAEHYKIP PLGKHYSQRW
210 220 230 240 250
AQEDLLEEQK DGARAAAVAD KKKGLMGPLT ELDTKDVDAL LKKSEAQHEQ
260 270 280 290 300
PEDGCPFGAL TQRLLQALVE ENIISPMEDS PIPDMSGKES GADGASTSPR
310 320 330 340 350
NQNKPFSVPH TKSLESRIKE ELIAQGLLES EDRPAEDSED EVLAELRKRQ
360 370 380 390 400
AELKALSAHN RTKKHDLLRL AKEEVSRQEL RQRVRMADNE VMDAFRKIMA
410 420 430
ARQKKRTPTK KEKDQAWKTL KERESILKLL DG
Length:432
Mass (Da):48,902
Last modified:November 1, 1998 - v1
Checksum:iC86153CFA83F9226
GO
Isoform 2 (identifier: O75528-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     370-432: Missing.

Show »
Length:369
Mass (Da):41,393
Checksum:i782715A6300779A4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti168 – 1681E → G in AK000228. (PubMed:14702039)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei370 – 43263Missing in isoform 2. 3 PublicationsVSP_009739Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF069733 mRNA. Translation: AAC39903.1.
AL117487 mRNA. Translation: CAB55957.1.
AK000228 mRNA. No translation available.
CR533543 mRNA. Translation: CAG38574.1.
CH471055 Genomic DNA. Translation: EAW63994.1.
BC009240 mRNA. Translation: AAH09240.1.
BC013433 mRNA. Translation: AAH13433.1.
CCDSiCCDS2583.1. [O75528-1]
CCDS2584.1. [O75528-2]
PIRiT17267.
RefSeqiNP_001265199.1. NM_001278270.1. [O75528-1]
NP_006345.1. NM_006354.3. [O75528-1]
NP_597814.1. NM_133480.2. [O75528-2]
UniGeneiHs.386390.

Genome annotation databases

EnsembliENST00000301964; ENSP00000307684; ENSG00000171148. [O75528-1]
ENST00000343450; ENSP00000343649; ENSG00000171148. [O75528-2]
ENST00000440161; ENSP00000393471; ENSG00000171148. [O75528-1]
GeneIDi10474.
KEGGihsa:10474.
UCSCiuc003bsw.2. human. [O75528-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF069733 mRNA. Translation: AAC39903.1 .
AL117487 mRNA. Translation: CAB55957.1 .
AK000228 mRNA. No translation available.
CR533543 mRNA. Translation: CAG38574.1 .
CH471055 Genomic DNA. Translation: EAW63994.1 .
BC009240 mRNA. Translation: AAH09240.1 .
BC013433 mRNA. Translation: AAH13433.1 .
CCDSi CCDS2583.1. [O75528-1 ]
CCDS2584.1. [O75528-2 ]
PIRi T17267.
RefSeqi NP_001265199.1. NM_001278270.1. [O75528-1 ]
NP_006345.1. NM_006354.3. [O75528-1 ]
NP_597814.1. NM_133480.2. [O75528-2 ]
UniGenei Hs.386390.

3D structure databases

ProteinModelPortali O75528.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115737. 57 interactions.
IntActi O75528. 19 interactions.
MINTi MINT-221730.
STRINGi 9606.ENSP00000307684.

PTM databases

PhosphoSitei O75528.

Proteomic databases

MaxQBi O75528.
PaxDbi O75528.
PRIDEi O75528.

Protocols and materials databases

DNASUi 10474.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000301964 ; ENSP00000307684 ; ENSG00000171148 . [O75528-1 ]
ENST00000343450 ; ENSP00000343649 ; ENSG00000171148 . [O75528-2 ]
ENST00000440161 ; ENSP00000393471 ; ENSG00000171148 . [O75528-1 ]
GeneIDi 10474.
KEGGi hsa:10474.
UCSCi uc003bsw.2. human. [O75528-1 ]

Organism-specific databases

CTDi 10474.
GeneCardsi GC03M009822.
HGNCi HGNC:19422. TADA3.
HPAi HPA042250.
MIMi 602945. gene.
neXtProti NX_O75528.
PharmGKBi PA165698494.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG265778.
GeneTreei ENSGT00390000008947.
HOGENOMi HOG000007362.
HOVERGENi HBG055283.
InParanoidi O75528.
KOi K11315.
OMAi QDKKGDK.
OrthoDBi EOG79PJP8.
PhylomeDBi O75528.
TreeFami TF323397.

Enzyme and pathway databases

Reactomei REACT_172610. HATs acetylate histones.

Miscellaneous databases

ChiTaRSi TADA3. human.
GeneWikii TADA3L.
GenomeRNAii 10474.
NextBioi 39724.
PROi O75528.
SOURCEi Search...

Gene expression databases

Bgeei O75528.
CleanExi HS_TADA3L.
ExpressionAtlasi O75528. baseline and differential.
Genevestigatori O75528.

Family and domain databases

InterProi IPR019340. Histone_AcTrfase_su3.
[Graphical view ]
Pfami PF10198. Ada3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, INTERACTION WITH PCAF; TAF5L; TAF6L; TAF9; TAF10 AND TAF12.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Colon mucosa.
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Muscle and Pancreas.
  7. "Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo."
    Martinez E., Palhan V.B., Tjernberg A., Lymar E.S., Gamper A.M., Kundu T.K., Chait B.T., Roeder R.G.
    Mol. Cell. Biol. 21:6782-6795(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE STAGA COMPLEX, SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
  8. "Human papillomavirus oncoprotein E6 inactivates the transcriptional coactivator human ADA3."
    Kumar A., Zhao Y., Meng G., Zeng M., Srinivasan S., Delmolino L.M., Gao Q., Dimri G., Weber G.F., Wazer D.E., Band H., Band V.
    Mol. Cell. Biol. 22:5801-5812(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TP53 AND THE HIGH-RISK HPV ONCOPROTEIN E6.
  9. Cited for: FUNCTION, INTERACTION WITH TP53.
  10. Cited for: REVIEW, PCAF COMPLEX COMPOSITION.
  11. "Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one-dimensional gel electrophoresis."
    Cavusoglu N., Brand M., Tora L., van Dorsselaer A.
    Proteomics 3:217-223(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE TFTC-HAT COMPLEX.
  12. "The double-histone-acetyltransferase complex ATAC is essential for mammalian development."
    Guelman S., Kozuka K., Mao Y., Pham V., Solloway M.J., Wang J., Wu J., Lill J.R., Zha J.
    Mol. Cell. Biol. 29:1176-1188(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN ATAC COMPLEX.
  13. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-418, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiTADA3_HUMAN
AccessioniPrimary (citable) accession number: O75528
Secondary accession number(s): Q6FI83, Q9UFS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: November 1, 1998
Last modified: October 29, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3