Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

RNA-binding motif protein, X-linked-like-2

Gene

RBMXL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. nucleotide binding Source: InterPro
  2. RNA binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding motif protein, X-linked-like-2
Alternative name(s):
Testis-specific heterogeneous nuclear ribonucleoprotein G-T
Short name:
hnRNP G-T
Gene namesi
Name:RBMXL2
Synonyms:HNRNPGT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:17886. RBMXL2.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
  2. ribonucleoprotein complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162400840.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 392392RNA-binding motif protein, X-linked-like-2PRO_0000281737Add
BLAST

Proteomic databases

MaxQBiO75526.
PaxDbiO75526.
PRIDEiO75526.

PTM databases

PhosphoSiteiO75526.

Expressioni

Tissue specificityi

Expressed predominantly in spermatocytes and less in round spermatids (at protein level). Expressed in germ cells.1 Publication

Gene expression databases

BgeeiO75526.
CleanExiHS_RBMXL2.
GenevestigatoriO75526.

Organism-specific databases

HPAiHPA038912.
HPA051842.

Interactioni

Protein-protein interaction databases

BioGridi118112. 10 interactions.
IntActiO75526. 7 interactions.
STRINGi9606.ENSP00000304139.

Structurei

3D structure databases

ProteinModelPortaliO75526.
SMRiO75526. Positions 1-90.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 8679RRMPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi93 – 391299Arg/Gly/Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG140744.
GeneTreeiENSGT00710000106295.
HOGENOMiHOG000276235.
HOVERGENiHBG063314.
InParanoidiO75526.
KOiK12885.
OMAiRAPMPMK.
OrthoDBiEOG780RPD.
PhylomeDBiO75526.
TreeFamiTF331833.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR012604. RBM1CTR.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF08081. RBM1CTR. 1 hit.
PF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O75526-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVEADRPGKL FIGGLNLETD EKALEAEFGK YGRIVEVLLM KDRETNKSRG
60 70 80 90 100
FAFVTFESPA DAKAAARDMN GKSLDGKAIK VAQATKPAFE SSRRGPPPPR
110 120 130 140 150
SRGRPRFLRG TRGGGGGPRR SPSRGGPDDD GGYTADFDLR PSRAPMPMKR
160 170 180 190 200
GPPPRRVGPP PKRAAPSGPA RSSGGGMRGR ALAVRGRDGY SGPPRREPLP
210 220 230 240 250
PRRDPYLGPR DEGYSSRDGY SSRDYREPRG FAPSPGEYTH RDYGHSSVRD
260 270 280 290 300
DCPLRGYSDR DGYGGRDRDY GDHLSRGSHR EPFESYGELR GAAPGRGTPP
310 320 330 340 350
SYGGGGRYEE YRGYSPDAYS GGRDSYSSSY GRSDRYSRGR HRVGRPDRGL
360 370 380 390
SLSMERGCPP QRDSYSRSGC RVPRGGGRLG GRLERGGGRS RY
Length:392
Mass (Da):42,814
Last modified:May 4, 2009 - v3
Checksum:iCE7B79EF3C64197B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti15 – 151L → F.1 Publication
Corresponds to variant rs17857474 [ dbSNP | Ensembl ].
VAR_055334
Natural varianti66 – 661A → V.1 Publication
Corresponds to variant rs11041170 [ dbSNP | Ensembl ].
VAR_061833
Natural varianti134 – 1341T → A.3 Publications
Corresponds to variant rs11041171 [ dbSNP | Ensembl ].
VAR_055335
Natural varianti308 – 3081Y → C.1 Publication
Corresponds to variant rs17854944 [ dbSNP | Ensembl ].
VAR_055336

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF069682 mRNA. Translation: AAC24858.2.
AC100875 Genomic DNA. No translation available.
BC057796 mRNA. Translation: AAH57796.1.
AF279289 Genomic DNA. Translation: AAF82129.1.
CCDSiCCDS7777.1.
RefSeqiNP_055284.3. NM_014469.4.
UniGeneiHs.121605.

Genome annotation databases

EnsembliENST00000306904; ENSP00000304139; ENSG00000170748.
GeneIDi27288.
KEGGihsa:27288.
UCSCiuc001mfc.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF069682 mRNA. Translation: AAC24858.2.
AC100875 Genomic DNA. No translation available.
BC057796 mRNA. Translation: AAH57796.1.
AF279289 Genomic DNA. Translation: AAF82129.1.
CCDSiCCDS7777.1.
RefSeqiNP_055284.3. NM_014469.4.
UniGeneiHs.121605.

3D structure databases

ProteinModelPortaliO75526.
SMRiO75526. Positions 1-90.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118112. 10 interactions.
IntActiO75526. 7 interactions.
STRINGi9606.ENSP00000304139.

PTM databases

PhosphoSiteiO75526.

Proteomic databases

MaxQBiO75526.
PaxDbiO75526.
PRIDEiO75526.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306904; ENSP00000304139; ENSG00000170748.
GeneIDi27288.
KEGGihsa:27288.
UCSCiuc001mfc.2. human.

Organism-specific databases

CTDi27288.
GeneCardsiGC11P007068.
H-InvDBHIX0035856.
HIX0171337.
HGNCiHGNC:17886. RBMXL2.
HPAiHPA038912.
HPA051842.
MIMi605444. gene.
neXtProtiNX_O75526.
PharmGKBiPA162400840.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG140744.
GeneTreeiENSGT00710000106295.
HOGENOMiHOG000276235.
HOVERGENiHBG063314.
InParanoidiO75526.
KOiK12885.
OMAiRAPMPMK.
OrthoDBiEOG780RPD.
PhylomeDBiO75526.
TreeFamiTF331833.

Miscellaneous databases

GenomeRNAii27288.
NextBioi50232.
PROiO75526.
SOURCEiSearch...

Gene expression databases

BgeeiO75526.
CleanExiHS_RBMXL2.
GenevestigatoriO75526.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR012604. RBM1CTR.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF08081. RBM1CTR. 1 hit.
PF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Newton C.S., Venables J.P., Eperon I.C.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ALA-134.
    Tissue: Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS PHE-15; ALA-134 AND CYS-308.
    Tissue: Brain.
  4. "An evolutionarily conserved germ cell-specific hnRNP is encoded by a retrotransposed gene."
    Elliott D.J., Venables J.P., Newton C.S., Lawson D., Boyle S., Eperon I.C., Cooke H.J.
    Hum. Mol. Genet. 9:2117-2124(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 7-392, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, VARIANTS VAL-66 AND ALA-134.

Entry informationi

Entry nameiRMXL2_HUMAN
AccessioniPrimary (citable) accession number: O75526
Secondary accession number(s): Q6PEZ2, Q9NQU0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 19, 2007
Last sequence update: May 4, 2009
Last modified: January 6, 2015
This is version 109 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.