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Protein

RNA-binding motif protein, X-linked-like-2

Gene

RBMXL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding motif protein, X-linked-like-2
Alternative name(s):
Testis-specific heterogeneous nuclear ribonucleoprotein G-T
Short name:
hnRNP G-T
Gene namesi
Name:RBMXL2
Synonyms:HNRNPGT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000170748.6.
HGNCiHGNC:17886. RBMXL2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi27288.
OpenTargetsiENSG00000170748.
PharmGKBiPA162400840.

Polymorphism and mutation databases

BioMutaiRBMXL2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002817371 – 392RNA-binding motif protein, X-linked-like-2Add BLAST392

Proteomic databases

EPDiO75526.
MaxQBiO75526.
PaxDbiO75526.
PeptideAtlasiO75526.
PRIDEiO75526.

PTM databases

iPTMnetiO75526.
PhosphoSitePlusiO75526.

Expressioni

Tissue specificityi

Expressed predominantly in spermatocytes and less in round spermatids (at protein level). Expressed in germ cells.1 Publication

Gene expression databases

BgeeiENSG00000170748.
CleanExiHS_RBMXL2.
GenevisibleiO75526. HS.

Organism-specific databases

HPAiHPA038912.
HPA051842.

Interactioni

Protein-protein interaction databases

BioGridi118112. 11 interactors.
IntActiO75526. 8 interactors.
STRINGi9606.ENSP00000304139.

Structurei

3D structure databases

ProteinModelPortaliO75526.
SMRiO75526.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 86RRMPROSITE-ProRule annotationAdd BLAST79

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi93 – 391Arg/Gly/Pro-richAdd BLAST299

Phylogenomic databases

eggNOGiENOG410IHG3. Eukaryota.
ENOG4111GI6. LUCA.
GeneTreeiENSGT00710000106295.
HOGENOMiHOG000276235.
HOVERGENiHBG063314.
InParanoidiO75526.
KOiK12885.
OMAiLSMERGC.
OrthoDBiEOG091G13K0.
PhylomeDBiO75526.
TreeFamiTF331833.

Family and domain databases

InterProiView protein in InterPro
IPR012604. RBM1CTR.
IPR000504. RRM_dom.
IPR003954. RRM_dom_euk.
PfamiView protein in Pfam
PF08081. RBM1CTR. 1 hit.
PF00076. RRM_1. 1 hit.
SMARTiView protein in SMART
SM00360. RRM. 1 hit.
SM00361. RRM_1. 1 hit.
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiView protein in PROSITE
PS50102. RRM. 1 hit.

Sequencei

Sequence statusi: Complete.

O75526-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVEADRPGKL FIGGLNLETD EKALEAEFGK YGRIVEVLLM KDRETNKSRG
60 70 80 90 100
FAFVTFESPA DAKAAARDMN GKSLDGKAIK VAQATKPAFE SSRRGPPPPR
110 120 130 140 150
SRGRPRFLRG TRGGGGGPRR SPSRGGPDDD GGYTADFDLR PSRAPMPMKR
160 170 180 190 200
GPPPRRVGPP PKRAAPSGPA RSSGGGMRGR ALAVRGRDGY SGPPRREPLP
210 220 230 240 250
PRRDPYLGPR DEGYSSRDGY SSRDYREPRG FAPSPGEYTH RDYGHSSVRD
260 270 280 290 300
DCPLRGYSDR DGYGGRDRDY GDHLSRGSHR EPFESYGELR GAAPGRGTPP
310 320 330 340 350
SYGGGGRYEE YRGYSPDAYS GGRDSYSSSY GRSDRYSRGR HRVGRPDRGL
360 370 380 390
SLSMERGCPP QRDSYSRSGC RVPRGGGRLG GRLERGGGRS RY
Length:392
Mass (Da):42,814
Last modified:May 5, 2009 - v3
Checksum:iCE7B79EF3C64197B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05533415L → F1 PublicationCorresponds to variant dbSNP:rs17857474Ensembl.1
Natural variantiVAR_06183366A → V1 PublicationCorresponds to variant dbSNP:rs11041170Ensembl.1
Natural variantiVAR_055335134T → A3 PublicationsCorresponds to variant dbSNP:rs11041171Ensembl.1
Natural variantiVAR_055336308Y → C1 PublicationCorresponds to variant dbSNP:rs17854944Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF069682 mRNA. Translation: AAC24858.2.
AC100875 Genomic DNA. No translation available.
BC057796 mRNA. Translation: AAH57796.1.
AF279289 Genomic DNA. Translation: AAF82129.1.
CCDSiCCDS7777.1.
RefSeqiNP_055284.3. NM_014469.4.
UniGeneiHs.121605.

Genome annotation databases

EnsembliENST00000306904; ENSP00000304139; ENSG00000170748.
GeneIDi27288.
KEGGihsa:27288.
UCSCiuc001mfc.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRMXL2_HUMAN
AccessioniPrimary (citable) accession number: O75526
Secondary accession number(s): Q6PEZ2, Q9NQU0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: May 5, 2009
Last modified: September 27, 2017
This is version 127 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot