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O75526

- RMXL2_HUMAN

UniProt

O75526 - RMXL2_HUMAN

Protein

RNA-binding motif protein, X-linked-like-2

Gene

RBMXL2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 3 (05 May 2009)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. nucleotide binding Source: InterPro
    2. RNA binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Ribonucleoprotein

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA-binding motif protein, X-linked-like-2
    Alternative name(s):
    Testis-specific heterogeneous nuclear ribonucleoprotein G-T
    Short name:
    hnRNP G-T
    Gene namesi
    Name:RBMXL2
    Synonyms:HNRNPGT
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:17886. RBMXL2.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell
    2. ribonucleoprotein complex Source: UniProtKB-KW

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162400840.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 392392RNA-binding motif protein, X-linked-like-2PRO_0000281737Add
    BLAST

    Proteomic databases

    MaxQBiO75526.
    PaxDbiO75526.
    PRIDEiO75526.

    PTM databases

    PhosphoSiteiO75526.

    Expressioni

    Tissue specificityi

    Expressed predominantly in spermatocytes and less in round spermatids (at protein level). Expressed in germ cells.1 Publication

    Gene expression databases

    BgeeiO75526.
    CleanExiHS_RBMXL2.
    GenevestigatoriO75526.

    Organism-specific databases

    HPAiHPA038912.
    HPA051842.

    Interactioni

    Protein-protein interaction databases

    BioGridi118112. 10 interactions.
    IntActiO75526. 7 interactions.
    STRINGi9606.ENSP00000304139.

    Structurei

    3D structure databases

    ProteinModelPortaliO75526.
    SMRiO75526. Positions 1-90.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini8 – 8679RRMPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi93 – 391299Arg/Gly/Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG140744.
    HOGENOMiHOG000276235.
    HOVERGENiHBG063314.
    InParanoidiO75526.
    KOiK12885.
    OMAiRAPMPMK.
    OrthoDBiEOG780RPD.
    PhylomeDBiO75526.
    TreeFamiTF331833.

    Family and domain databases

    Gene3Di3.30.70.330. 1 hit.
    InterProiIPR012677. Nucleotide-bd_a/b_plait.
    IPR012604. RBM1CTR.
    IPR000504. RRM_dom.
    [Graphical view]
    PfamiPF08081. RBM1CTR. 1 hit.
    PF00076. RRM_1. 1 hit.
    [Graphical view]
    SMARTiSM00360. RRM. 1 hit.
    [Graphical view]
    PROSITEiPS50102. RRM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O75526-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVEADRPGKL FIGGLNLETD EKALEAEFGK YGRIVEVLLM KDRETNKSRG    50
    FAFVTFESPA DAKAAARDMN GKSLDGKAIK VAQATKPAFE SSRRGPPPPR 100
    SRGRPRFLRG TRGGGGGPRR SPSRGGPDDD GGYTADFDLR PSRAPMPMKR 150
    GPPPRRVGPP PKRAAPSGPA RSSGGGMRGR ALAVRGRDGY SGPPRREPLP 200
    PRRDPYLGPR DEGYSSRDGY SSRDYREPRG FAPSPGEYTH RDYGHSSVRD 250
    DCPLRGYSDR DGYGGRDRDY GDHLSRGSHR EPFESYGELR GAAPGRGTPP 300
    SYGGGGRYEE YRGYSPDAYS GGRDSYSSSY GRSDRYSRGR HRVGRPDRGL 350
    SLSMERGCPP QRDSYSRSGC RVPRGGGRLG GRLERGGGRS RY 392
    Length:392
    Mass (Da):42,814
    Last modified:May 5, 2009 - v3
    Checksum:iCE7B79EF3C64197B
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti15 – 151L → F.1 Publication
    Corresponds to variant rs17857474 [ dbSNP | Ensembl ].
    VAR_055334
    Natural varianti66 – 661A → V.1 Publication
    Corresponds to variant rs11041170 [ dbSNP | Ensembl ].
    VAR_061833
    Natural varianti134 – 1341T → A.3 Publications
    Corresponds to variant rs11041171 [ dbSNP | Ensembl ].
    VAR_055335
    Natural varianti308 – 3081Y → C.1 Publication
    Corresponds to variant rs17854944 [ dbSNP | Ensembl ].
    VAR_055336

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF069682 mRNA. Translation: AAC24858.2.
    AC100875 Genomic DNA. No translation available.
    BC057796 mRNA. Translation: AAH57796.1.
    AF279289 Genomic DNA. Translation: AAF82129.1.
    CCDSiCCDS7777.1.
    RefSeqiNP_055284.3. NM_014469.4.
    UniGeneiHs.121605.

    Genome annotation databases

    EnsembliENST00000306904; ENSP00000304139; ENSG00000170748.
    GeneIDi27288.
    KEGGihsa:27288.
    UCSCiuc001mfc.2. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF069682 mRNA. Translation: AAC24858.2 .
    AC100875 Genomic DNA. No translation available.
    BC057796 mRNA. Translation: AAH57796.1 .
    AF279289 Genomic DNA. Translation: AAF82129.1 .
    CCDSi CCDS7777.1.
    RefSeqi NP_055284.3. NM_014469.4.
    UniGenei Hs.121605.

    3D structure databases

    ProteinModelPortali O75526.
    SMRi O75526. Positions 1-90.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118112. 10 interactions.
    IntActi O75526. 7 interactions.
    STRINGi 9606.ENSP00000304139.

    PTM databases

    PhosphoSitei O75526.

    Proteomic databases

    MaxQBi O75526.
    PaxDbi O75526.
    PRIDEi O75526.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000306904 ; ENSP00000304139 ; ENSG00000170748 .
    GeneIDi 27288.
    KEGGi hsa:27288.
    UCSCi uc001mfc.2. human.

    Organism-specific databases

    CTDi 27288.
    GeneCardsi GC11P007068.
    H-InvDB HIX0035856.
    HIX0171337.
    HGNCi HGNC:17886. RBMXL2.
    HPAi HPA038912.
    HPA051842.
    MIMi 605444. gene.
    neXtProti NX_O75526.
    PharmGKBi PA162400840.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG140744.
    HOGENOMi HOG000276235.
    HOVERGENi HBG063314.
    InParanoidi O75526.
    KOi K12885.
    OMAi RAPMPMK.
    OrthoDBi EOG780RPD.
    PhylomeDBi O75526.
    TreeFami TF331833.

    Miscellaneous databases

    GenomeRNAii 27288.
    NextBioi 50232.
    PROi O75526.
    SOURCEi Search...

    Gene expression databases

    Bgeei O75526.
    CleanExi HS_RBMXL2.
    Genevestigatori O75526.

    Family and domain databases

    Gene3Di 3.30.70.330. 1 hit.
    InterProi IPR012677. Nucleotide-bd_a/b_plait.
    IPR012604. RBM1CTR.
    IPR000504. RRM_dom.
    [Graphical view ]
    Pfami PF08081. RBM1CTR. 1 hit.
    PF00076. RRM_1. 1 hit.
    [Graphical view ]
    SMARTi SM00360. RRM. 1 hit.
    [Graphical view ]
    PROSITEi PS50102. RRM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Newton C.S., Venables J.P., Eperon I.C.
      Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ALA-134.
      Tissue: Testis.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS PHE-15; ALA-134 AND CYS-308.
      Tissue: Brain.
    4. "An evolutionarily conserved germ cell-specific hnRNP is encoded by a retrotransposed gene."
      Elliott D.J., Venables J.P., Newton C.S., Lawson D., Boyle S., Eperon I.C., Cooke H.J.
      Hum. Mol. Genet. 9:2117-2124(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 7-392, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, VARIANTS VAL-66 AND ALA-134.

    Entry informationi

    Entry nameiRMXL2_HUMAN
    AccessioniPrimary (citable) accession number: O75526
    Secondary accession number(s): Q6PEZ2, Q9NQU0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 2007
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 106 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3