O75526 (RMXL2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
RNA-binding motif protein, X-linked-like-2

Alternative name(s):
Testis-specific heterogeneous nuclear ribonucleoprotein G-T
Short name=hnRNP G-T

Gene names

Name:	RBMXL2
Synonyms:	HNRNPGT

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	392 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Nucleus Ref.4.
Tissue specificity	Expressed predominantly in spermatocytes and less in round spermatids (at protein level). Expressed in germ cells. Ref.4
Sequence similarities	Contains 1 RRM (RNA recognition motif) domain.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Ligand	RNA-binding
Molecular function	Ribonucleoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	nucleus Inferred from direct assay. Source: HPA ribonucleoprotein complex Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 392	392	RNA-binding motif protein, X-linked-like-2		PRO_0000281737
Regions
	Domain	8 – 86	79	RRM
	Compositional bias	93 – 391	299	Arg/Gly/Pro-rich
Natural variations
	Natural variant	15	1	L → F. Ref.3 Corresponds to variant rs17857474 [ dbSNP | Ensembl ].		VAR_055334
	Natural variant	66	1	A → V. Ref.4 Corresponds to variant rs11041170 [ dbSNP | Ensembl ].		VAR_061833
	Natural variant	134	1	T → A. Ref.1 Ref.3 Ref.4 Corresponds to variant rs11041171 [ dbSNP | Ensembl ].		VAR_055335
	Natural variant	308	1	Y → C. Ref.3 Corresponds to variant rs17854944 [ dbSNP | Ensembl ].		VAR_055336

Sequences

	Sequence		Length	Mass (Da)
	O75526 [UniParc]. Last modified May 5, 2009. Version 3. Checksum: CE7B79EF3C64197B	FASTA	392	42,814
	10 20 30 40 50 60 MVEADRPGKL FIGGLNLETD EKALEAEFGK YGRIVEVLLM KDRETNKSRG FAFVTFESPA 70 80 90 100 110 120 DAKAAARDMN GKSLDGKAIK VAQATKPAFE SSRRGPPPPR SRGRPRFLRG TRGGGGGPRR 130 140 150 160 170 180 SPSRGGPDDD GGYTADFDLR PSRAPMPMKR GPPPRRVGPP PKRAAPSGPA RSSGGGMRGR 190 200 210 220 230 240 ALAVRGRDGY SGPPRREPLP PRRDPYLGPR DEGYSSRDGY SSRDYREPRG FAPSPGEYTH 250 260 270 280 290 300 RDYGHSSVRD DCPLRGYSDR DGYGGRDRDY GDHLSRGSHR EPFESYGELR GAAPGRGTPP 310 320 330 340 350 360 SYGGGGRYEE YRGYSPDAYS GGRDSYSSSY GRSDRYSRGR HRVGRPDRGL SLSMERGCPP 370 380 390 QRDSYSRSGC RVPRGGGRLG GRLERGGGRS RY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Newton C.S., Venables J.P., Eperon I.C. Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ALA-134. Tissue: Testis.
[2]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS PHE-15; ALA-134 AND CYS-308. Tissue: Brain.
[4]	"An evolutionarily conserved germ cell-specific hnRNP is encoded by a retrotransposed gene." Elliott D.J., Venables J.P., Newton C.S., Lawson D., Boyle S., Eperon I.C., Cooke H.J. Hum. Mol. Genet. 9:2117-2124(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 7-392, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, VARIANTS VAL-66 AND ALA-134.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF069682 mRNA. Translation: AAC24858.2. AC100875 Genomic DNA. No translation available. BC057796 mRNA. Translation: AAH57796.1. AF279289 Genomic DNA. Translation: AAF82129.1.
IPI	IPI00004450.
RefSeq	NP_055284.3. NM_014469.4.
UniGene	Hs.121605.
3D structure databases
HSSP	HSSP built from PDB template 1X5S based on UniProtKB Q14011.
ProteinModelPortal	O75526.
ModBase	Search...
Protein-protein interaction databases
IntAct	O75526. 6 interactions.
STRING	9606.ENSP00000304139.
PTM databases
PhosphoSite	O75526.
Proteomic databases
PaxDb	O75526.
PRIDE	O75526.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000306904; ENSP00000304139; ENSG00000170748.
GeneID	27288.
KEGG	hsa:27288.
UCSC	uc001mfc.2. human.
Organism-specific databases
CTD	27288.
GeneCards	GC11P007068.
H-InvDB	HIX0035856. HIX0171337.
HGNC	HGNC:17886. RBMXL2.
HPA	HPA038912. HPA051842.
MIM	605444. gene.
neXtProt	NX_O75526.
PharmGKB	PA162400840.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG140744.
HOGENOM	HOG000276235.
HOVERGEN	HBG063314.
InParanoid	O75526.
OMA	GDFDLRP.
OrthoDB	EOG4WSWBK.
PhylomeDB	O75526.
Gene expression databases
Bgee	O75526.
CleanEx	HS_RBMXL2.
Genevestigator	O75526.
Family and domain databases
Gene3D	3.30.70.330. 1 hit.
InterPro	IPR012677. Nucleotide-bd_a/b_plait. IPR012604. RBM1CTR. IPR000504. RRM_dom. [Graphical view]
Pfam	PF08081. RBM1CTR. 1 hit. PF00076. RRM_1. 1 hit. [Graphical view]
SMART	SM00360. RRM. 1 hit. [Graphical view]
PROSITE	PS50102. RRM. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	27288.
NextBio	50232.
SOURCE	Search...

Entry information

Entry name

RMXL2_HUMAN

Accession

Primary (citable) accession number: O75526
Secondary accession number(s): Q6PEZ2, Q9NQU0

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	May 5, 2009
Last modified:	May 1, 2013
This is version 94 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.