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O75526 (RMXL2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
RNA-binding motif protein, X-linked-like-2
Alternative name(s):
Testis-specific heterogeneous nuclear ribonucleoprotein G-T
Short name=hnRNP G-T
Gene names
Name:RBMXL2
Synonyms:HNRNPGT
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length392 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Nucleus Ref.4.

Tissue specificity

Expressed predominantly in spermatocytes and less in round spermatids (at protein level). Expressed in germ cells. Ref.4

Sequence similarities

Contains 1 RRM (RNA recognition motif) domain.

Ontologies

Keywords
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   LigandRNA-binding
   Molecular functionRibonucleoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

ribonucleoprotein complex

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionRNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

nucleotide binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 392392RNA-binding motif protein, X-linked-like-2
PRO_0000281737

Regions

Domain8 – 8679RRM
Compositional bias93 – 391299Arg/Gly/Pro-rich

Natural variations

Natural variant151L → F. Ref.3
Corresponds to variant rs17857474 [ dbSNP | Ensembl ].
VAR_055334
Natural variant661A → V. Ref.4
Corresponds to variant rs11041170 [ dbSNP | Ensembl ].
VAR_061833
Natural variant1341T → A. Ref.1 Ref.3 Ref.4
Corresponds to variant rs11041171 [ dbSNP | Ensembl ].
VAR_055335
Natural variant3081Y → C. Ref.3
Corresponds to variant rs17854944 [ dbSNP | Ensembl ].
VAR_055336

Sequences

Sequence LengthMass (Da)Tools
O75526 [UniParc].

Last modified May 5, 2009. Version 3.
Checksum: CE7B79EF3C64197B

FASTA39242,814
        10         20         30         40         50         60 
MVEADRPGKL FIGGLNLETD EKALEAEFGK YGRIVEVLLM KDRETNKSRG FAFVTFESPA 

        70         80         90        100        110        120 
DAKAAARDMN GKSLDGKAIK VAQATKPAFE SSRRGPPPPR SRGRPRFLRG TRGGGGGPRR 

       130        140        150        160        170        180 
SPSRGGPDDD GGYTADFDLR PSRAPMPMKR GPPPRRVGPP PKRAAPSGPA RSSGGGMRGR 

       190        200        210        220        230        240 
ALAVRGRDGY SGPPRREPLP PRRDPYLGPR DEGYSSRDGY SSRDYREPRG FAPSPGEYTH 

       250        260        270        280        290        300 
RDYGHSSVRD DCPLRGYSDR DGYGGRDRDY GDHLSRGSHR EPFESYGELR GAAPGRGTPP 

       310        320        330        340        350        360 
SYGGGGRYEE YRGYSPDAYS GGRDSYSSSY GRSDRYSRGR HRVGRPDRGL SLSMERGCPP 

       370        380        390 
QRDSYSRSGC RVPRGGGRLG GRLERGGGRS RY 

« Hide

References

« Hide 'large scale' references
[1]Newton C.S., Venables J.P., Eperon I.C.
Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ALA-134.
Tissue: Testis.
[2]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS PHE-15; ALA-134 AND CYS-308.
Tissue: Brain.
[4]"An evolutionarily conserved germ cell-specific hnRNP is encoded by a retrotransposed gene."
Elliott D.J., Venables J.P., Newton C.S., Lawson D., Boyle S., Eperon I.C., Cooke H.J.
Hum. Mol. Genet. 9:2117-2124(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 7-392, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, VARIANTS VAL-66 AND ALA-134.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF069682 mRNA. Translation: AAC24858.2.
AC100875 Genomic DNA. No translation available.
BC057796 mRNA. Translation: AAH57796.1.
AF279289 Genomic DNA. Translation: AAF82129.1.
CCDSCCDS7777.1.
RefSeqNP_055284.3. NM_014469.4.
UniGeneHs.121605.

3D structure databases

ProteinModelPortalO75526.
SMRO75526. Positions 1-90.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid118112. 10 interactions.
IntActO75526. 7 interactions.
STRING9606.ENSP00000304139.

PTM databases

PhosphoSiteO75526.

Proteomic databases

MaxQBO75526.
PaxDbO75526.
PRIDEO75526.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000306904; ENSP00000304139; ENSG00000170748.
GeneID27288.
KEGGhsa:27288.
UCSCuc001mfc.2. human.

Organism-specific databases

CTD27288.
GeneCardsGC11P007068.
H-InvDBHIX0035856.
HIX0171337.
HGNCHGNC:17886. RBMXL2.
HPAHPA038912.
HPA051842.
MIM605444. gene.
neXtProtNX_O75526.
PharmGKBPA162400840.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG140744.
HOGENOMHOG000276235.
HOVERGENHBG063314.
InParanoidO75526.
KOK12885.
OMARAPMPMK.
OrthoDBEOG780RPD.
PhylomeDBO75526.
TreeFamTF331833.

Gene expression databases

BgeeO75526.
CleanExHS_RBMXL2.
GenevestigatorO75526.

Family and domain databases

Gene3D3.30.70.330. 1 hit.
InterProIPR012677. Nucleotide-bd_a/b_plait.
IPR012604. RBM1CTR.
IPR000504. RRM_dom.
[Graphical view]
PfamPF08081. RBM1CTR. 1 hit.
PF00076. RRM_1. 1 hit.
[Graphical view]
SMARTSM00360. RRM. 1 hit.
[Graphical view]
PROSITEPS50102. RRM. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi27288.
NextBio50232.
PROO75526.
SOURCESearch...

Entry information

Entry nameRMXL2_HUMAN
AccessionPrimary (citable) accession number: O75526
Secondary accession number(s): Q6PEZ2, Q9NQU0
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: May 5, 2009
Last modified: July 9, 2014
This is version 105 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM