O75521 (ECI2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Enoyl-CoA delta isomerase 2, mitochondrial
EC=5.3.3.8

Alternative name(s):
DRS-1
Delta(3),delta(2)-enoyl-CoA isomerase
Short name=D3,D2-enoyl-CoA isomerase
Diazepam-binding inhibitor-related protein 1
Short name=DBI-related protein 1
Dodecenoyl-CoA isomerase
Hepatocellular carcinoma-associated antigen 88
Peroxisomal 3,2-trans-enoyl-CoA isomerase
Short name=pECI
Renal carcinoma antigen NY-REN-1

Gene names

Name:	ECI2
Synonyms:	DRS1, HCA88, PECI

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	394 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. Has a preference for 3-trans substrates By similarity.
Catalytic activity	(3Z)-dodec-3-enoyl-CoA = (2E)-dodec-2-enoyl-CoA.
Subcellular location	Isoform 1: Mitochondrion By similarity Ref.6 Ref.9. Isoform 2: Peroxisome matrix Ref.6 Ref.9.
Tissue specificity	Abundant in heart, skeletal muscle and liver. Expressed in CD34+ T-cells and CD34+ bone marrow cells. Ref.10
Sequence similarities	In the C-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. Contains 1 ACB (acyl-CoA-binding) domain.
Caution	It is uncertain whether Met-1 or Met-3 is the initiator.
Sequence caution	The sequence AAC19317.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence AAD34173.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAF66247.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAH02668.3 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAH16781.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence AAH17474.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence AAH33841.3 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence AAH34702.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence BAG52068.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Cellular component	Mitochondrion Peroxisome
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transit peptide
Molecular function	Isomerase
PTM	Acetylation
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	fatty acid catabolic process Inferred from direct assay Ref.6. Source: UniProtKB
Cellular_component	mitochondrion Inferred from direct assay. Source: LIFEdb peroxisomal matrix Inferred from direct assay Ref.6. Source: UniProtKB
Molecular_function	dodecenoyl-CoA delta-isomerase activity Inferred from direct assay Ref.6. Source: UniProtKB fatty-acyl-CoA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O75521-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O75521-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-35: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Transit peptide

1 – 38

38

Mitochondrion Potential

Chain

39 – 394

356

Enoyl-CoA delta isomerase 2, mitochondrial

PRO_0000214027

Regions

Domain

39 – 124

86

ACB

Region

66 – 70

5

Acyl-CoA binding By similarity

Region

151 – 322

172

ECH-like

Motif

392 – 394

3

Microbody targeting signal Potential

Sites

Binding site

92

1

Acyl-CoA By similarity

Binding site

111

1

Acyl-CoA By similarity

Amino acid modifications

Modified residue

51

1

N6-acetyllysine Ref.11

Modified residue

62

1

N6-acetyllysine By similarity

Modified residue

92

1

N6-acetyllysine Ref.11

Natural variations

Alternative sequence

1 – 35

35

Missing in isoform 2.

VSP_037854

Natural variant

47

1

M → I.
Corresponds to variant rs3177253 [ dbSNP | Ensembl ].

VAR_058493

Natural variant

344

1

A → V. Ref.1 Ref.7
Corresponds to variant rs7166 [ dbSNP | Ensembl ].

VAR_058494

Experimental info

Sequence conflict

119

1

S → C in CAB66577. Ref.2

Sequence conflict

195

1

Y → C in AAC19317. Ref.1

Secondary structure

1

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394

Helix Strand Turn

Details...

Helix

40 – 52

13

Helix

59 – 69

11

Turn

70 – 74

5

Helix

87 – 99

13

Helix

104 – 118

15

Beta strand

140 – 147

8

Beta strand

150 – 155

6

Helix

158 – 160

3

Helix

166 – 181

16

Beta strand

185 – 192

8

Helix

212 – 232

21

Beta strand

238 – 242

5

Helix

249 – 252

4

Helix

253 – 256

4

Beta strand

258 – 263

6

Beta strand

267 – 269

3

Helix

273 – 275

3

Helix

283 – 291

9

Helix

293 – 300

8

Helix

308 – 313

6

Beta strand

318 – 321

4

Turn

323 – 325

3

Helix

326 – 337

12

Helix

342 – 353

12

Helix

354 – 356

3

Helix

357 – 375

19

Helix

378 – 381

4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified September 1, 2009. Version 4. Checksum: 8AC633D43A320102	FASTA	394	43,585
	10 20 30 40 50 60 MAMAYLAWRL ARRSCPSSLQ VTSFPVVQLH MNRTAMRASQ KDFENSMNQV KLLKKDPGNE 70 80 90 100 110 120 VKLKLYALYK QATEGPCNMP KPGVFDLINK AKWDAWNALG SLPKEAARQN YVDLVSSLSP 130 140 150 160 170 180 SLESSSQVEP GTDRKSTGFE TLVVTSEDGI TKIMFNRPKK KNAINTEMYH EIMRALKAAS 190 200 210 220 230 240 KDDSIITVLT GNGDYYSSGN DLTNFTDIPP GGVEEKAKNN AVLLREFVGC FIDFPKPLIA 250 260 270 280 290 300 VVNGPAVGIS VTLLGLFDAV YASDRATFHT PFSHLGQSPE GCSSYTFPKI MSPAKATEML 310 320 330 340 350 360 IFGKKLTAGE ACAQGLVTEV FPDSTFQKEV WTRLKAFAKL PPNALRISKE VIRKREREKL 370 380 390 HAVNAEECNV LQGRWLSDEC TNAVVNFLSR KSKL
	Isoform 2 [UniParc]. Checksum: B9EC60A0D445C9F0	FASTA	359	39,609
	10 20 30 40 50 60 MRASQKDFEN SMNQVKLLKK DPGNEVKLKL YALYKQATEG PCNMPKPGVF DLINKAKWDA 70 80 90 100 110 120 WNALGSLPKE AARQNYVDLV SSLSPSLESS SQVEPGTDRK STGFETLVVT SEDGITKIMF 130 140 150 160 170 180 NRPKKKNAIN TEMYHEIMRA LKAASKDDSI ITVLTGNGDY YSSGNDLTNF TDIPPGGVEE 190 200 210 220 230 240 KAKNNAVLLR EFVGCFIDFP KPLIAVVNGP AVGISVTLLG LFDAVYASDR ATFHTPFSHL 250 260 270 280 290 300 GQSPEGCSSY TFPKIMSPAK ATEMLIFGKK LTAGEACAQG LVTEVFPDST FQKEVWTRLK 310 320 330 340 350 AFAKLPPNAL RISKEVIRKR EREKLHAVNA EECNVLQGRW LSDECTNAVV NFLSRKSKL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and expression of a novel human cDNA related to the diazepam binding inhibitor." Suk K., Kim Y.-H., Hwang D.-Y., Ihm S.-H., Yoo H.J., Lee M.-S. Biochim. Biophys. Acta 1454:126-131(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT VAL-344. Tissue: Pancreatic islet.
[2]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Placenta.
[4]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Bone marrow, Skin and Uterus.
[6]	"Characterization of PECI, a novel monofunctional D3,D2-enoyl-CoA isomerase of mammalian peroxisomes." Geisbrecht B.V., Zhang D., Schulz H., Gould S.J. J. Biol. Chem. 274:21797-21803(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-394 (ISOFORM 1), SUBCELLULAR LOCATION.
[7]	"Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies." Wang Y., Han K.-J., Pang X.-W., Vaughan H.A., Qu W., Dong X.-Y., Peng J.-R., Zhao H.-T., Rui J.-A., Leng X.-S., Cebon J., Burgess A.W., Chen W.-F. J. Immunol. 169:1102-1109(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-394 (ISOFORM 1), VARIANT VAL-344. Tissue: Hepatoma.
[8]	"Antigens recognized by autologous antibody in patients with renal-cell carcinoma." Scanlan M.J., Gordan J.D., Williamson B., Stockert E., Bander N.H., Jongeneel C.V., Gure A.O., Jaeger D., Jaeger E., Knuth A., Chen Y.-T., Old L.J. Int. J. Cancer 83:456-464(1999) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION AS A RENAL CANCER ANTIGEN. Tissue: Renal cell carcinoma.
[9]	"Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing." Simpson J.C., Wellenreuther R., Poustka A., Pepperkok R., Wiemann S. EMBO Rep. 1:287-292(2000) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION.
[10]	"Diazepam-binding inhibitor-related protein 1: a candidate autoantigen in acquired aplastic anemia patients harboring a minor population of paroxysmal nocturnal hemoglobinuria-type cells." Feng X., Chuhjo T., Sugimori C., Kotani T., Lu X., Takami A., Takamatsu H., Yamazaki H., Nakao S. Blood 104:2425-2431(2004) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[11]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-51 AND LYS-92, MASS SPECTROMETRY.
[12]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[13]	"Solution structure of RSGI RUH-045, a human acyl-CoA binding protein." RIKEN structural genomics initiative (RSGI) Submitted (NOV-2005) to the PDB data bank Cited for: STRUCTURE BY NMR OF 36-133.
[14]	"The crystal structure of human peroxisomal delta3, delta2 enoyl-CoA isomerase (pECI)." Structural genomics consortium (SGC) Submitted (FEB-2009) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 138-394.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF069301 mRNA. Translation: AAC19317.1. Different initiation.
AL136642 mRNA. Translation: CAB66577.1.
AK075108 mRNA. Translation: BAG52068.1. Different initiation.
AL033383 Genomic DNA. Translation: CAI42125.1.
AL033383 Genomic DNA. Translation: CAI42127.1.
BC002668 mRNA. Translation: AAH02668.3. Different initiation.
BC016781 mRNA. Translation: AAH16781.1. Different initiation.
BC017474 mRNA. Translation: AAH17474.1. Different initiation.
BC033841 mRNA. Translation: AAH33841.3. Different initiation.
BC034702 mRNA. Translation: AAH34702.1. Different initiation.
AF153612 mRNA. Translation: AAD34173.1. Different initiation.
AF244138 mRNA. Translation: AAF66247.1. Different initiation.

IPI

IPI00419263.
IPI00639841.

RefSeq

NP_001159482.1. NM_001166010.1.
NP_006108.2. NM_006117.2.
NP_996667.2. NM_206836.2.

UniGene

Hs.15250.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2CQU	NMR	-	A	31-133	[»]
2F6Q	X-ray	1.95	A/B/C	138-394	[»]

ProteinModelPortal

O75521.

ModBase

Search...

Protein-protein interaction databases

IntAct

O75521. 5 interactions.

PTM databases

PhosphoSite

O75521.

2D gel databases

REPRODUCTION-2DPAGE

IPI00419263.

UCD-2DPAGE

O75521.

Proteomic databases

PaxDb

O75521.

PRIDE

O75521.

Protocols and materials databases

DNASU

10455.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000361538; ENSP00000354737; ENSG00000198721.
ENST00000380118; ENSP00000369461; ENSG00000198721.
ENST00000380125; ENSP00000369468; ENSG00000198721.
ENST00000465828; ENSP00000420309; ENSG00000198721.

GeneID

10455.

KEGG

hsa:10455.

UCSC

uc003mwc.3. human.

Organism-specific databases

CTD

10455.

GeneCards

GC06M004115.

H-InvDB

HIX0025043.

HGNC

HGNC:14601. ECI2.

HPA

HPA022130.

MIM

608024. gene.

neXtProt

NX_O75521.

PharmGKB

PA33168.

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG4281.

HOVERGEN

HBG006723.

InParanoid

O75521.

KO

K13239.

OMA

RWLSDEC.

OrthoDB

EOG49P9ZK.

Gene expression databases

ArrayExpress

O75521.

Bgee

O75521.

Genevestigator

O75521.

GermOnline

ENSG00000198721. Homo sapiens.

Family and domain databases

Gene3D

1.20.80.10. 1 hit.

InterPro

IPR022408. Acyl-CoA-binding_prot_CS.
IPR000582. Acyl-CoA-binding_protein.
IPR001753. Crotonase_core_superfam.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
[Graphical view]

Pfam

PF00887. ACBP. 1 hit.
PF00378. ECH. 1 hit.
[Graphical view]

PRINTS

PR00689. ACOABINDINGP.

SUPFAM

SSF47027. ACBP. 1 hit.

PROSITE

PS00880. ACB_1. 1 hit.
PS51228. ACB_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

O75521.

GenomeRNAi

10455.

NextBio

39633.

SOURCE

Search...

Entry information

Entry name

ECI2_HUMAN

Accession

Primary (citable) accession number: O75521
Secondary accession number(s): Q5JYK5 , Q5JYK7, Q7L124, Q8N0X0, Q9BUE9, Q9H0T9, Q9NQH1, Q9NYH7, Q9UN55

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	September 1, 2009
Last modified:	May 1, 2013
This is version 137 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.