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Protein

Claudin-11

Gene

CLDN11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000013297-MONOMER.
ReactomeiR-HSA-420029. Tight junction interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-11
Alternative name(s):
Oligodendrocyte-specific protein
Gene namesi
Name:CLDN11
Synonyms:OSP, OTM
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:8514. CLDN11.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1CytoplasmicSequence analysis1
Transmembranei2 – 22HelicalSequence analysisAdd BLAST21
Topological domaini23 – 82ExtracellularSequence analysisAdd BLAST60
Transmembranei83 – 103HelicalSequence analysisAdd BLAST21
Topological domaini104 – 122CytoplasmicSequence analysisAdd BLAST19
Transmembranei123 – 143HelicalSequence analysisAdd BLAST21
Topological domaini144 – 157ExtracellularSequence analysisAdd BLAST14
Transmembranei158 – 178HelicalSequence analysisAdd BLAST21
Topological domaini179 – 207CytoplasmicSequence analysisAdd BLAST29

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

Pathology & Biotechi

Organism-specific databases

DisGeNETi5010.
OpenTargetsiENSG00000013297.
PharmGKBiPA26559.

Polymorphism and mutation databases

BioMutaiCLDN11.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001447601 – 207Claudin-11Add BLAST207

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei197PhosphoserineBy similarity1
Modified residuei198PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO75508.
PeptideAtlasiO75508.
PRIDEiO75508.

PTM databases

iPTMnetiO75508.
PhosphoSitePlusiO75508.
SwissPalmiO75508.

Expressioni

Gene expression databases

BgeeiENSG00000013297.
CleanExiHS_CLDN11.
ExpressionAtlasiO75508. baseline and differential.
GenevisibleiO75508. HS.

Organism-specific databases

HPAiCAB009789.
HPA013166.

Interactioni

Subunit structurei

Interacts with tetraspanin-3/TSPAN3.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9606.ENSP00000064724.

Structurei

3D structure databases

ProteinModelPortaliO75508.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEXU. Eukaryota.
ENOG41101XN. LUCA.
GeneTreeiENSGT00760000119222.
HOGENOMiHOG000220937.
HOVERGENiHBG102313.
InParanoidiO75508.
KOiK06087.
OMAiYSLYTGW.
OrthoDBiEOG091G0MX2.
PhylomeDBiO75508.
TreeFamiTF331936.

Family and domain databases

InterProiIPR006187. Claudin.
IPR003555. Claudin11.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PTHR12002:SF6. PTHR12002:SF6. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01384. CLAUDIN11.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O75508-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVATCLQVVG FVTSFVGWIG VIVTTSTNDW VVTCGYTIPT CRKLDELGSK
60 70 80 90 100
GLWADCVMAT GLYHCKPLVD ILILPGYVQA CRALMIAASV LGLPAILLLL
110 120 130 140 150
TVLPCIRMGQ EPGVAKYRRA QLAGVLLILL ALCALVATIW FPVCAHRETT
160 170 180 190 200
IVSFGYSLYA GWIGAVLCLV GGCVILCCAG DAQAFGENRF YYTAGSSSPT

HAKSAHV
Length:207
Mass (Da):21,993
Last modified:May 30, 2000 - v2
Checksum:i4FF79C676FCAFA47
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti160A → T in AAV38209 (Ref. 3) Curated1
Sequence conflicti160A → T in AAV38210 (Ref. 3) Curated1
Sequence conflicti189 – 207RFYYT…KSAHV → VSTTLRALAPRLMRRVPTYK RAARLPTEVL in AAC25187 (PubMed:10700007).CuratedAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF068863 mRNA. Translation: AAC25187.1.
AJ245901 mRNA. Translation: CAB55487.1.
BT019402 mRNA. Translation: AAV38209.1.
BT019403 mRNA. Translation: AAV38210.1.
AK312923 mRNA. Translation: BAG35768.1.
CH471052 Genomic DNA. Translation: EAW78505.1.
CH471052 Genomic DNA. Translation: EAW78509.1.
BC013577 mRNA. Translation: AAH13577.1.
CCDSiCCDS3213.1.
RefSeqiNP_005593.2. NM_005602.5.
UniGeneiHs.31595.

Genome annotation databases

EnsembliENST00000064724; ENSP00000064724; ENSG00000013297.
GeneIDi5010.
KEGGihsa:5010.
UCSCiuc003fgx.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF068863 mRNA. Translation: AAC25187.1.
AJ245901 mRNA. Translation: CAB55487.1.
BT019402 mRNA. Translation: AAV38209.1.
BT019403 mRNA. Translation: AAV38210.1.
AK312923 mRNA. Translation: BAG35768.1.
CH471052 Genomic DNA. Translation: EAW78505.1.
CH471052 Genomic DNA. Translation: EAW78509.1.
BC013577 mRNA. Translation: AAH13577.1.
CCDSiCCDS3213.1.
RefSeqiNP_005593.2. NM_005602.5.
UniGeneiHs.31595.

3D structure databases

ProteinModelPortaliO75508.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000064724.

PTM databases

iPTMnetiO75508.
PhosphoSitePlusiO75508.
SwissPalmiO75508.

Polymorphism and mutation databases

BioMutaiCLDN11.

Proteomic databases

PaxDbiO75508.
PeptideAtlasiO75508.
PRIDEiO75508.

Protocols and materials databases

DNASUi5010.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000064724; ENSP00000064724; ENSG00000013297.
GeneIDi5010.
KEGGihsa:5010.
UCSCiuc003fgx.4. human.

Organism-specific databases

CTDi5010.
DisGeNETi5010.
GeneCardsiCLDN11.
HGNCiHGNC:8514. CLDN11.
HPAiCAB009789.
HPA013166.
MIMi601326. gene.
neXtProtiNX_O75508.
OpenTargetsiENSG00000013297.
PharmGKBiPA26559.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEXU. Eukaryota.
ENOG41101XN. LUCA.
GeneTreeiENSGT00760000119222.
HOGENOMiHOG000220937.
HOVERGENiHBG102313.
InParanoidiO75508.
KOiK06087.
OMAiYSLYTGW.
OrthoDBiEOG091G0MX2.
PhylomeDBiO75508.
TreeFamiTF331936.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000013297-MONOMER.
ReactomeiR-HSA-420029. Tight junction interactions.

Miscellaneous databases

ChiTaRSiCLDN11. human.
GeneWikiiCLDN11.
GenomeRNAii5010.
PROiO75508.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000013297.
CleanExiHS_CLDN11.
ExpressionAtlasiO75508. baseline and differential.
GenevisibleiO75508. HS.

Family and domain databases

InterProiIPR006187. Claudin.
IPR003555. Claudin11.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PTHR12002:SF6. PTHR12002:SF6. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01384. CLAUDIN11.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLD11_HUMAN
AccessioniPrimary (citable) accession number: O75508
Secondary accession number(s): B2R7C1, D3DNQ5, Q5U0P3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: November 30, 2016
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.