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Protein

Claudin-11

Gene

CLDN11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-420029. Tight junction interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-11
Alternative name(s):
Oligodendrocyte-specific protein
Gene namesi
Name:CLDN11
Synonyms:OSP, OTM
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000013297.10.
HGNCiHGNC:8514. CLDN11.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1CytoplasmicSequence analysis1
Transmembranei2 – 22HelicalSequence analysisAdd BLAST21
Topological domaini23 – 82ExtracellularSequence analysisAdd BLAST60
Transmembranei83 – 103HelicalSequence analysisAdd BLAST21
Topological domaini104 – 122CytoplasmicSequence analysisAdd BLAST19
Transmembranei123 – 143HelicalSequence analysisAdd BLAST21
Topological domaini144 – 157ExtracellularSequence analysisAdd BLAST14
Transmembranei158 – 178HelicalSequence analysisAdd BLAST21
Topological domaini179 – 207CytoplasmicSequence analysisAdd BLAST29

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

Pathology & Biotechi

Organism-specific databases

DisGeNETi5010.
OpenTargetsiENSG00000013297.
PharmGKBiPA26559.

Polymorphism and mutation databases

BioMutaiCLDN11.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001447601 – 207Claudin-11Add BLAST207

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei197PhosphoserineBy similarity1
Modified residuei198PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO75508.
PaxDbiO75508.
PeptideAtlasiO75508.
PRIDEiO75508.

PTM databases

iPTMnetiO75508.
PhosphoSitePlusiO75508.
SwissPalmiO75508.

Expressioni

Gene expression databases

BgeeiENSG00000013297.
CleanExiHS_CLDN11.
ExpressionAtlasiO75508. baseline and differential.
GenevisibleiO75508. HS.

Organism-specific databases

HPAiCAB009789.
HPA013166.

Interactioni

Subunit structurei

Interacts with tetraspanin-3/TSPAN3 (By similarity). Interacts with OCLN (PubMed:20375010).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiO75508. 4 interactors.
STRINGi9606.ENSP00000064724.

Structurei

3D structure databases

ProteinModelPortaliO75508.
SMRiO75508.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEXU. Eukaryota.
ENOG41101XN. LUCA.
GeneTreeiENSGT00890000139496.
HOGENOMiHOG000220937.
HOVERGENiHBG102313.
InParanoidiO75508.
KOiK06087.
OMAiYSLYTGW.
OrthoDBiEOG091G0MX2.
PhylomeDBiO75508.
TreeFamiTF331936.

Family and domain databases

InterProiView protein in InterPro
IPR006187. Claudin.
IPR003555. Claudin11.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
PANTHERiPTHR12002. PTHR12002. 1 hit.
PTHR12002:SF153. PTHR12002:SF153. 1 hit.
PfamiView protein in Pfam
PF00822. PMP22_Claudin. 1 hit.
PRINTSiPR01384. CLAUDIN11.
PROSITEiView protein in PROSITE
PS01346. CLAUDIN. 1 hit.

Sequencei

Sequence statusi: Complete.

O75508-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVATCLQVVG FVTSFVGWIG VIVTTSTNDW VVTCGYTIPT CRKLDELGSK
60 70 80 90 100
GLWADCVMAT GLYHCKPLVD ILILPGYVQA CRALMIAASV LGLPAILLLL
110 120 130 140 150
TVLPCIRMGQ EPGVAKYRRA QLAGVLLILL ALCALVATIW FPVCAHRETT
160 170 180 190 200
IVSFGYSLYA GWIGAVLCLV GGCVILCCAG DAQAFGENRF YYTAGSSSPT

HAKSAHV
Length:207
Mass (Da):21,993
Last modified:May 30, 2000 - v2
Checksum:i4FF79C676FCAFA47
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti160A → T in AAV38209 (Ref. 3) Curated1
Sequence conflicti160A → T in AAV38210 (Ref. 3) Curated1
Sequence conflicti189 – 207RFYYT…KSAHV → VSTTLRALAPRLMRRVPTYK RAARLPTEVL in AAC25187 (PubMed:10700007).CuratedAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF068863 mRNA. Translation: AAC25187.1.
AJ245901 mRNA. Translation: CAB55487.1.
BT019402 mRNA. Translation: AAV38209.1.
BT019403 mRNA. Translation: AAV38210.1.
AK312923 mRNA. Translation: BAG35768.1.
CH471052 Genomic DNA. Translation: EAW78505.1.
CH471052 Genomic DNA. Translation: EAW78509.1.
BC013577 mRNA. Translation: AAH13577.1.
CCDSiCCDS3213.1.
RefSeqiNP_005593.2. NM_005602.5.
UniGeneiHs.31595.

Genome annotation databases

EnsembliENST00000064724; ENSP00000064724; ENSG00000013297.
GeneIDi5010.
KEGGihsa:5010.
UCSCiuc003fgx.4. human.

Similar proteinsi

Entry informationi

Entry nameiCLD11_HUMAN
AccessioniPrimary (citable) accession number: O75508
Secondary accession number(s): B2R7C1, D3DNQ5, Q5U0P3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: September 27, 2017
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families