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Protein

Heat shock factor-binding protein 1

Gene

HSBP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process.

GO - Molecular functioni

  • transcription corepressor activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_264071. HSF1 activation.
REACT_264075. Attenuation phase.
REACT_264164. HSF1-dependent transactivation.

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock factor-binding protein 1
Alternative name(s):
Nasopharyngeal carcinoma-associated antigen 13
Short name:
NPC-A-13
Gene namesi
Name:HSBP1
Synonyms:HSF1BP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:5203. HSBP1.

Subcellular locationi

GO - Cellular componenti

  • cytoskeleton Source: Ensembl
  • nucleoplasm Source: Reactome
  • nucleus Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi16 – 161V → K: Loss of interaction with HSF1; in association with K-19. 1 Publication
Mutagenesisi19 – 191L → K: Loss of interaction with HSF1; in association with K-16. 1 Publication
Mutagenesisi45 – 451I → K: Loss of interaction with HSF1; in association with K-48. 1 Publication
Mutagenesisi48 – 481L → K: Loss of interaction with HSF1; in association with K-45. 1 Publication

Organism-specific databases

PharmGKBiPA29475.

Polymorphism and mutation databases

BioMutaiHSBP1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7676Heat shock factor-binding protein 1PRO_0000124805Add
BLAST

Proteomic databases

MaxQBiO75506.
PaxDbiO75506.
PRIDEiO75506.

PTM databases

PhosphoSiteiO75506.

Expressioni

Gene expression databases

BgeeiO75506.
CleanExiHS_HSBP1.
ExpressionAtlasiO75506. baseline and differential.
GenevisibleiO75506. HS.

Organism-specific databases

HPAiHPA028940.

Interactioni

Subunit structurei

Homohexamer. Associates with heptad repeats of HSF1 trimers and problaby also HSF1 monomers, and with HSP70. Association with HSF1 trimers and HSP70 coincides with attenuation of heat shock response and the conversion of HSF1 trimer to monomer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CCDC53Q9Y3C06EBI-748664,EBI-712969
CCHCR1Q8TD31-33EBI-748664,EBI-10175300
KIAA1217Q5T5P2-65EBI-748664,EBI-10188326
KIFC3Q9BVG85EBI-748664,EBI-2125614
KRTAP10-7P604093EBI-748664,EBI-10172290
LNX1Q8TBB13EBI-748664,EBI-739832
NOTCH2NLQ7Z3S93EBI-748664,EBI-945833
SDCBPO005605EBI-748664,EBI-727004

Protein-protein interaction databases

BioGridi109515. 18 interactions.
IntActiO75506. 11 interactions.
MINTiMINT-1455497.
STRINGi9606.ENSP00000392896.

Structurei

Secondary structure

1
76
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi9 – 4638Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3CI9X-ray1.80A/B6-53[»]
ProteinModelPortaliO75506.
SMRiO75506. Positions 9-53.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO75506.

Family & Domainsi

Sequence similaritiesi

Belongs to the HSBP1 family.Curated

Phylogenomic databases

eggNOGiNOG317556.
GeneTreeiENSGT00390000006293.
HOGENOMiHOG000217518.
HOVERGENiHBG051930.
InParanoidiO75506.
OMAiMSCRIDD.
OrthoDBiEOG754HS8.
PhylomeDBiO75506.
TreeFamiTF314005.

Family and domain databases

InterProiIPR009643. HS1-bd.
[Graphical view]
PANTHERiPTHR19424. PTHR19424. 1 hit.
PfamiPF06825. HSBP1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O75506-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAETDPKTVQ DLTSVVQTLL QQMQDKFQTM SDQIIGRIDD MSSRIDDLEK
60 70
NIADLMTQAG VEELESENKI PATQKS
Length:76
Mass (Da):8,544
Last modified:November 1, 1998 - v1
Checksum:i9838423C86B2D402
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti31 – 311S → A in AAP73809 (Ref. 2) Curated
Sequence conflicti72 – 721A → V in AAP73809 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF068754 mRNA. Translation: AAC25186.1.
AY320409 mRNA. Translation: AAP73809.1.
BX537440 mRNA. Translation: CAD97682.1.
BC007515 mRNA. Translation: AAH07515.1.
CCDSiCCDS45534.1.
RefSeqiNP_001528.1. NM_001537.3.
UniGeneiHs.250899.

Genome annotation databases

EnsembliENST00000433866; ENSP00000392896; ENSG00000230989.
ENST00000570259; ENSP00000458007; ENSG00000230989.
GeneIDi3281.
KEGGihsa:3281.
UCSCiuc002fgy.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF068754 mRNA. Translation: AAC25186.1.
AY320409 mRNA. Translation: AAP73809.1.
BX537440 mRNA. Translation: CAD97682.1.
BC007515 mRNA. Translation: AAH07515.1.
CCDSiCCDS45534.1.
RefSeqiNP_001528.1. NM_001537.3.
UniGeneiHs.250899.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3CI9X-ray1.80A/B6-53[»]
ProteinModelPortaliO75506.
SMRiO75506. Positions 9-53.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109515. 18 interactions.
IntActiO75506. 11 interactions.
MINTiMINT-1455497.
STRINGi9606.ENSP00000392896.

PTM databases

PhosphoSiteiO75506.

Polymorphism and mutation databases

BioMutaiHSBP1.

Proteomic databases

MaxQBiO75506.
PaxDbiO75506.
PRIDEiO75506.

Protocols and materials databases

DNASUi3281.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000433866; ENSP00000392896; ENSG00000230989.
ENST00000570259; ENSP00000458007; ENSG00000230989.
GeneIDi3281.
KEGGihsa:3281.
UCSCiuc002fgy.2. human.

Organism-specific databases

CTDi3281.
GeneCardsiGC16P083841.
HGNCiHGNC:5203. HSBP1.
HPAiHPA028940.
MIMi604553. gene.
neXtProtiNX_O75506.
PharmGKBiPA29475.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG317556.
GeneTreeiENSGT00390000006293.
HOGENOMiHOG000217518.
HOVERGENiHBG051930.
InParanoidiO75506.
OMAiMSCRIDD.
OrthoDBiEOG754HS8.
PhylomeDBiO75506.
TreeFamiTF314005.

Enzyme and pathway databases

ReactomeiREACT_264071. HSF1 activation.
REACT_264075. Attenuation phase.
REACT_264164. HSF1-dependent transactivation.

Miscellaneous databases

ChiTaRSiHSBP1. human.
EvolutionaryTraceiO75506.
GenomeRNAii3281.
NextBioi13027.
PROiO75506.
SOURCEiSearch...

Gene expression databases

BgeeiO75506.
CleanExiHS_HSBP1.
ExpressionAtlasiO75506. baseline and differential.
GenevisibleiO75506. HS.

Family and domain databases

InterProiIPR009643. HS1-bd.
[Graphical view]
PANTHERiPTHR19424. PTHR19424. 1 hit.
PfamiPF06825. HSBP1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Negative regulation of the heat shock transcriptional response by HSBP1."
    Satyal S.H., Chen D., Fox S.G., Kramer J.M., Morimoto R.I.
    Genes Dev. 12:1962-1974(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], MUTAGENESIS.
  2. "Construction of cDNA expression library from nasopharyngeal carcinoma tissue and screening of antigenic genes."
    Shu J., Li G., He X.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Fetal brain.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Muscle.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Crystal structure of the hexamer of human heat shock factor binding protein 1."
    Liu X., Xu L., Liu Y., Tong X., Zhu G., Zhang X.C., Li X., Rao Z.
    Proteins 75:1-11(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 6-53 OF MUTANT ILE-31 AND PRO-56, SUBUNIT.

Entry informationi

Entry nameiHSBP1_HUMAN
AccessioniPrimary (citable) accession number: O75506
Secondary accession number(s): Q53XA8, Q7Z5Z3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: July 22, 2015
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.