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Protein

Heat shock factor-binding protein 1

Gene

HSBP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process.

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • transcription corepressor activity Source: ProtInc

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-3371511 HSF1 activation
R-HSA-3371568 Attenuation phase
R-HSA-3371571 HSF1-dependent transactivation

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock factor-binding protein 1
Alternative name(s):
Nasopharyngeal carcinoma-associated antigen 13
Short name:
NPC-A-13
Gene namesi
Name:HSBP1
Synonyms:HSF1BP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000230989.6
HGNCiHGNC:5203 HSBP1
MIMi604553 gene
neXtProtiNX_O75506

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi16V → K: Loss of interaction with HSF1; in association with K-19. 1 Publication1
Mutagenesisi19L → K: Loss of interaction with HSF1; in association with K-16. 1 Publication1
Mutagenesisi45I → K: Loss of interaction with HSF1; in association with K-48. 1 Publication1
Mutagenesisi48L → K: Loss of interaction with HSF1; in association with K-45. 1 Publication1

Organism-specific databases

DisGeNETi3281
OpenTargetsiENSG00000230989
PharmGKBiPA29475

Polymorphism and mutation databases

BioMutaiHSBP1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001248051 – 76Heat shock factor-binding protein 1Add BLAST76

Proteomic databases

EPDiO75506
MaxQBiO75506
PaxDbiO75506
PeptideAtlasiO75506
PRIDEiO75506
TopDownProteomicsiO75506

PTM databases

iPTMnetiO75506
PhosphoSitePlusiO75506

Expressioni

Gene expression databases

BgeeiENSG00000230989
CleanExiHS_HSBP1
ExpressionAtlasiO75506 baseline and differential
GenevisibleiO75506 HS

Interactioni

Subunit structurei

Homohexamer. Associates with heptad repeats of HSF1 trimers and probably also HSF1 monomers, and with HSP70. Association with HSF1 trimers and HSP70 coincides with attenuation of heat shock response and the conversion of HSF1 trimer to monomer.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi10951529 interactors.
IntActiO75506 21 interactors.
STRINGi9606.ENSP00000392896

Structurei

Secondary structure

176
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi9 – 46Combined sources38

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3CI9X-ray1.80A/B6-53[»]
ProteinModelPortaliO75506
SMRiO75506
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO75506

Family & Domainsi

Sequence similaritiesi

Belongs to the HSBP1 family.Curated

Phylogenomic databases

eggNOGiKOG4117 Eukaryota
ENOG41122JH LUCA
GeneTreeiENSGT00390000006293
HOGENOMiHOG000217518
HOVERGENiHBG051930
InParanoidiO75506
KOiK19765
OMAiMSDQIIN
OrthoDBiEOG091G14ZN
PhylomeDBiO75506
TreeFamiTF314005

Family and domain databases

InterProiView protein in InterPro
IPR009643 HS1-bd
PANTHERiPTHR19424 PTHR19424, 1 hit
PfamiView protein in Pfam
PF06825 HSBP1, 1 hit

Sequencei

Sequence statusi: Complete.

O75506-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAETDPKTVQ DLTSVVQTLL QQMQDKFQTM SDQIIGRIDD MSSRIDDLEK
60 70
NIADLMTQAG VEELESENKI PATQKS
Length:76
Mass (Da):8,544
Last modified:November 1, 1998 - v1
Checksum:i9838423C86B2D402
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti31S → A in AAP73809 (Ref. 2) Curated1
Sequence conflicti72A → V in AAP73809 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF068754 mRNA Translation: AAC25186.1
AY320409 mRNA Translation: AAP73809.1
BX537440 mRNA Translation: CAD97682.1
BC007515 mRNA Translation: AAH07515.1
CCDSiCCDS45534.1
RefSeqiNP_001528.1, NM_001537.3
UniGeneiHs.250899

Genome annotation databases

EnsembliENST00000433866; ENSP00000392896; ENSG00000230989
ENST00000570259; ENSP00000458007; ENSG00000230989
GeneIDi3281
KEGGihsa:3281
UCSCiuc002fgy.3 human

Similar proteinsi

Entry informationi

Entry nameiHSBP1_HUMAN
AccessioniPrimary (citable) accession number: O75506
Secondary accession number(s): Q53XA8, Q7Z5Z3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: March 28, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome