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O75506 (HSBP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Heat shock factor-binding protein 1
Alternative name(s):
Nasopharyngeal carcinoma-associated antigen 13
Short name=NPC-A-13
Gene names
Name:HSBP1
Synonyms:HSF1BP
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length76 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process.

Subunit structure

Homohexamer. Associates with heptad repeats of HSF1 trimers and problaby also HSF1 monomers, and with HSP70. Association with HSF1 trimers and HSP70 coincides with attenuation of heat shock response and the conversion of HSF1 trimer to monomer. Ref.6

Subcellular location

Nucleus.

Sequence similarities

Belongs to the HSBP1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 7676Heat shock factor-binding protein 1
PRO_0000124805

Experimental info

Mutagenesis161V → K: Loss of interaction with HSF1; in association with K-19.
Mutagenesis191L → K: Loss of interaction with HSF1; in association with K-16.
Mutagenesis451I → K: Loss of interaction with HSF1; in association with K-48.
Mutagenesis481L → K: Loss of interaction with HSF1; in association with K-45.
Sequence conflict311S → A in AAP73809. Ref.2
Sequence conflict721A → V in AAP73809. Ref.2

Secondary structure

... 76
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
O75506 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 9838423C86B2D402

FASTA768,544
        10         20         30         40         50         60 
MAETDPKTVQ DLTSVVQTLL QQMQDKFQTM SDQIIGRIDD MSSRIDDLEK NIADLMTQAG 

        70 
VEELESENKI PATQKS 

« Hide

References

« Hide 'large scale' references
[1]"Negative regulation of the heat shock transcriptional response by HSBP1."
Satyal S.H., Chen D., Fox S.G., Kramer J.M., Morimoto R.I.
Genes Dev. 12:1962-1974(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], MUTAGENESIS.
[2]"Construction of cDNA expression library from nasopharyngeal carcinoma tissue and screening of antigenic genes."
Shu J., Li G., He X.
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Fetal brain.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Muscle.
[5]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[6]"Crystal structure of the hexamer of human heat shock factor binding protein 1."
Liu X., Xu L., Liu Y., Tong X., Zhu G., Zhang X.C., Li X., Rao Z.
Proteins 75:1-11(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 6-53 OF MUTANT ILE-31 AND PRO-56, SUBUNIT.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF068754 mRNA. Translation: AAC25186.1.
AY320409 mRNA. Translation: AAP73809.1.
BX537440 mRNA. Translation: CAD97682.1.
BC007515 mRNA. Translation: AAH07515.1.
RefSeqNP_001528.1. NM_001537.3.
UniGeneHs.250899.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3CI9X-ray1.80A/B6-53[»]
ProteinModelPortalO75506.
SMRO75506. Positions 9-53.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109515. 8 interactions.
IntActO75506. 4 interactions.
MINTMINT-1455497.
STRING9606.ENSP00000392896.

PTM databases

PhosphoSiteO75506.

Proteomic databases

PaxDbO75506.
PRIDEO75506.

Protocols and materials databases

DNASU3281.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000433866; ENSP00000392896; ENSG00000230989.
ENST00000570259; ENSP00000458007; ENSG00000230989.
GeneID3281.
KEGGhsa:3281.
UCSCuc002fgy.2. human.

Organism-specific databases

CTD3281.
GeneCardsGC16P083841.
HGNCHGNC:5203. HSBP1.
HPAHPA028940.
MIM604553. gene.
neXtProtNX_O75506.
PharmGKBPA29475.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG317556.
HOGENOMHOG000217518.
HOVERGENHBG051930.
InParanoidO75506.
OMAIYVQNLL.
OrthoDBEOG754HS8.
PhylomeDBO75506.
TreeFamTF314005.

Gene expression databases

ArrayExpressO75506.
BgeeO75506.
CleanExHS_HSBP1.
GenevestigatorO75506.

Family and domain databases

InterProIPR009643. HS1-bd.
[Graphical view]
PANTHERPTHR19424. PTHR19424. 1 hit.
PfamPF06825. HSBP1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceO75506.
GenomeRNAi3281.
NextBio13027.
PROO75506.
SOURCESearch...

Entry information

Entry nameHSBP1_HUMAN
AccessionPrimary (citable) accession number: O75506
Secondary accession number(s): Q53XA8, Q7Z5Z3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: April 16, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM