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O75506

- HSBP1_HUMAN

UniProt

O75506 - HSBP1_HUMAN

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Protein

Heat shock factor-binding protein 1

Gene
HSBP1, HSF1BP
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process.

GO - Molecular functioni

  1. transcription corepressor activity Source: ProtInc

GO - Biological processi

  1. muscle contraction Source: Ensembl
  2. negative regulation of transcription from RNA polymerase II promoter Source: ProtInc
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_200624. Attenuation phase.
REACT_200744. HSF1 activation.
REACT_200775. HSF1-dependent transactivation.

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock factor-binding protein 1
Alternative name(s):
Nasopharyngeal carcinoma-associated antigen 13
Short name:
NPC-A-13
Gene namesi
Name:HSBP1
Synonyms:HSF1BP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:5203. HSBP1.

Subcellular locationi

GO - Cellular componenti

  1. cytoskeleton Source: Ensembl
  2. nucleus Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi16 – 161V → K: Loss of interaction with HSF1; in association with K-19.
Mutagenesisi19 – 191L → K: Loss of interaction with HSF1; in association with K-16.
Mutagenesisi45 – 451I → K: Loss of interaction with HSF1; in association with K-48.
Mutagenesisi48 – 481L → K: Loss of interaction with HSF1; in association with K-45.

Organism-specific databases

PharmGKBiPA29475.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7676Heat shock factor-binding protein 1PRO_0000124805Add
BLAST

Proteomic databases

MaxQBiO75506.
PaxDbiO75506.
PRIDEiO75506.

PTM databases

PhosphoSiteiO75506.

Expressioni

Gene expression databases

ArrayExpressiO75506.
BgeeiO75506.
CleanExiHS_HSBP1.
GenevestigatoriO75506.

Organism-specific databases

HPAiHPA028940.

Interactioni

Subunit structurei

Homohexamer. Associates with heptad repeats of HSF1 trimers and problaby also HSF1 monomers, and with HSP70. Association with HSF1 trimers and HSP70 coincides with attenuation of heat shock response and the conversion of HSF1 trimer to monomer.1 Publication

Protein-protein interaction databases

BioGridi109515. 8 interactions.
IntActiO75506. 4 interactions.
MINTiMINT-1455497.
STRINGi9606.ENSP00000392896.

Structurei

Secondary structure

1
76
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi9 – 4638

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3CI9X-ray1.80A/B6-53[»]
ProteinModelPortaliO75506.
SMRiO75506. Positions 9-53.

Miscellaneous databases

EvolutionaryTraceiO75506.

Family & Domainsi

Sequence similaritiesi

Belongs to the HSBP1 family.

Phylogenomic databases

eggNOGiNOG317556.
HOGENOMiHOG000217518.
HOVERGENiHBG051930.
InParanoidiO75506.
OMAiPRKEINE.
OrthoDBiEOG754HS8.
PhylomeDBiO75506.
TreeFamiTF314005.

Family and domain databases

InterProiIPR009643. HS1-bd.
[Graphical view]
PANTHERiPTHR19424. PTHR19424. 1 hit.
PfamiPF06825. HSBP1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O75506-1 [UniParc]FASTAAdd to Basket

« Hide

MAETDPKTVQ DLTSVVQTLL QQMQDKFQTM SDQIIGRIDD MSSRIDDLEK   50
NIADLMTQAG VEELESENKI PATQKS 76
Length:76
Mass (Da):8,544
Last modified:November 1, 1998 - v1
Checksum:i9838423C86B2D402
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti31 – 311S → A in AAP73809. 1 Publication
Sequence conflicti72 – 721A → V in AAP73809. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF068754 mRNA. Translation: AAC25186.1.
AY320409 mRNA. Translation: AAP73809.1.
BX537440 mRNA. Translation: CAD97682.1.
BC007515 mRNA. Translation: AAH07515.1.
CCDSiCCDS45534.1.
RefSeqiNP_001528.1. NM_001537.3.
UniGeneiHs.250899.

Genome annotation databases

EnsembliENST00000433866; ENSP00000392896; ENSG00000230989.
ENST00000570259; ENSP00000458007; ENSG00000230989.
GeneIDi3281.
KEGGihsa:3281.
UCSCiuc002fgy.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF068754 mRNA. Translation: AAC25186.1 .
AY320409 mRNA. Translation: AAP73809.1 .
BX537440 mRNA. Translation: CAD97682.1 .
BC007515 mRNA. Translation: AAH07515.1 .
CCDSi CCDS45534.1.
RefSeqi NP_001528.1. NM_001537.3.
UniGenei Hs.250899.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3CI9 X-ray 1.80 A/B 6-53 [» ]
ProteinModelPortali O75506.
SMRi O75506. Positions 9-53.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109515. 8 interactions.
IntActi O75506. 4 interactions.
MINTi MINT-1455497.
STRINGi 9606.ENSP00000392896.

PTM databases

PhosphoSitei O75506.

Proteomic databases

MaxQBi O75506.
PaxDbi O75506.
PRIDEi O75506.

Protocols and materials databases

DNASUi 3281.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000433866 ; ENSP00000392896 ; ENSG00000230989 .
ENST00000570259 ; ENSP00000458007 ; ENSG00000230989 .
GeneIDi 3281.
KEGGi hsa:3281.
UCSCi uc002fgy.2. human.

Organism-specific databases

CTDi 3281.
GeneCardsi GC16P083841.
HGNCi HGNC:5203. HSBP1.
HPAi HPA028940.
MIMi 604553. gene.
neXtProti NX_O75506.
PharmGKBi PA29475.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG317556.
HOGENOMi HOG000217518.
HOVERGENi HBG051930.
InParanoidi O75506.
OMAi PRKEINE.
OrthoDBi EOG754HS8.
PhylomeDBi O75506.
TreeFami TF314005.

Enzyme and pathway databases

Reactomei REACT_200624. Attenuation phase.
REACT_200744. HSF1 activation.
REACT_200775. HSF1-dependent transactivation.

Miscellaneous databases

EvolutionaryTracei O75506.
GenomeRNAii 3281.
NextBioi 13027.
PROi O75506.
SOURCEi Search...

Gene expression databases

ArrayExpressi O75506.
Bgeei O75506.
CleanExi HS_HSBP1.
Genevestigatori O75506.

Family and domain databases

InterProi IPR009643. HS1-bd.
[Graphical view ]
PANTHERi PTHR19424. PTHR19424. 1 hit.
Pfami PF06825. HSBP1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Negative regulation of the heat shock transcriptional response by HSBP1."
    Satyal S.H., Chen D., Fox S.G., Kramer J.M., Morimoto R.I.
    Genes Dev. 12:1962-1974(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], MUTAGENESIS.
  2. "Construction of cDNA expression library from nasopharyngeal carcinoma tissue and screening of antigenic genes."
    Shu J., Li G., He X.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Fetal brain.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Muscle.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Crystal structure of the hexamer of human heat shock factor binding protein 1."
    Liu X., Xu L., Liu Y., Tong X., Zhu G., Zhang X.C., Li X., Rao Z.
    Proteins 75:1-11(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 6-53 OF MUTANT ILE-31 AND PRO-56, SUBUNIT.

Entry informationi

Entry nameiHSBP1_HUMAN
AccessioniPrimary (citable) accession number: O75506
Secondary accession number(s): Q53XA8, Q7Z5Z3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: September 3, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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