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O75506

- HSBP1_HUMAN

UniProt

O75506 - HSBP1_HUMAN

Protein

Heat shock factor-binding protein 1

Gene

HSBP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process.

    GO - Molecular functioni

    1. transcription corepressor activity Source: ProtInc

    GO - Biological processi

    1. muscle contraction Source: Ensembl
    2. negative regulation of transcription from RNA polymerase II promoter Source: ProtInc

    Enzyme and pathway databases

    ReactomeiREACT_200624. Attenuation phase.
    REACT_200744. HSF1 activation.
    REACT_200775. HSF1-dependent transactivation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Heat shock factor-binding protein 1
    Alternative name(s):
    Nasopharyngeal carcinoma-associated antigen 13
    Short name:
    NPC-A-13
    Gene namesi
    Name:HSBP1
    Synonyms:HSF1BP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:5203. HSBP1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoskeleton Source: Ensembl
    2. nucleus Source: ProtInc

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi16 – 161V → K: Loss of interaction with HSF1; in association with K-19. 1 Publication
    Mutagenesisi19 – 191L → K: Loss of interaction with HSF1; in association with K-16. 1 Publication
    Mutagenesisi45 – 451I → K: Loss of interaction with HSF1; in association with K-48. 1 Publication
    Mutagenesisi48 – 481L → K: Loss of interaction with HSF1; in association with K-45. 1 Publication

    Organism-specific databases

    PharmGKBiPA29475.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 7676Heat shock factor-binding protein 1PRO_0000124805Add
    BLAST

    Proteomic databases

    MaxQBiO75506.
    PaxDbiO75506.
    PRIDEiO75506.

    PTM databases

    PhosphoSiteiO75506.

    Expressioni

    Gene expression databases

    ArrayExpressiO75506.
    BgeeiO75506.
    CleanExiHS_HSBP1.
    GenevestigatoriO75506.

    Organism-specific databases

    HPAiHPA028940.

    Interactioni

    Subunit structurei

    Homohexamer. Associates with heptad repeats of HSF1 trimers and problaby also HSF1 monomers, and with HSP70. Association with HSF1 trimers and HSP70 coincides with attenuation of heat shock response and the conversion of HSF1 trimer to monomer.1 Publication

    Protein-protein interaction databases

    BioGridi109515. 8 interactions.
    IntActiO75506. 4 interactions.
    MINTiMINT-1455497.
    STRINGi9606.ENSP00000392896.

    Structurei

    Secondary structure

    1
    76
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi9 – 4638

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3CI9X-ray1.80A/B6-53[»]
    ProteinModelPortaliO75506.
    SMRiO75506. Positions 9-53.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO75506.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the HSBP1 family.Curated

    Phylogenomic databases

    eggNOGiNOG317556.
    HOGENOMiHOG000217518.
    HOVERGENiHBG051930.
    InParanoidiO75506.
    OMAiPRKEINE.
    OrthoDBiEOG754HS8.
    PhylomeDBiO75506.
    TreeFamiTF314005.

    Family and domain databases

    InterProiIPR009643. HS1-bd.
    [Graphical view]
    PANTHERiPTHR19424. PTHR19424. 1 hit.
    PfamiPF06825. HSBP1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O75506-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAETDPKTVQ DLTSVVQTLL QQMQDKFQTM SDQIIGRIDD MSSRIDDLEK   50
    NIADLMTQAG VEELESENKI PATQKS 76
    Length:76
    Mass (Da):8,544
    Last modified:November 1, 1998 - v1
    Checksum:i9838423C86B2D402
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti31 – 311S → A in AAP73809. 1 PublicationCurated
    Sequence conflicti72 – 721A → V in AAP73809. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF068754 mRNA. Translation: AAC25186.1.
    AY320409 mRNA. Translation: AAP73809.1.
    BX537440 mRNA. Translation: CAD97682.1.
    BC007515 mRNA. Translation: AAH07515.1.
    CCDSiCCDS45534.1.
    RefSeqiNP_001528.1. NM_001537.3.
    UniGeneiHs.250899.

    Genome annotation databases

    EnsembliENST00000433866; ENSP00000392896; ENSG00000230989.
    ENST00000570259; ENSP00000458007; ENSG00000230989.
    GeneIDi3281.
    KEGGihsa:3281.
    UCSCiuc002fgy.2. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF068754 mRNA. Translation: AAC25186.1 .
    AY320409 mRNA. Translation: AAP73809.1 .
    BX537440 mRNA. Translation: CAD97682.1 .
    BC007515 mRNA. Translation: AAH07515.1 .
    CCDSi CCDS45534.1.
    RefSeqi NP_001528.1. NM_001537.3.
    UniGenei Hs.250899.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3CI9 X-ray 1.80 A/B 6-53 [» ]
    ProteinModelPortali O75506.
    SMRi O75506. Positions 9-53.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109515. 8 interactions.
    IntActi O75506. 4 interactions.
    MINTi MINT-1455497.
    STRINGi 9606.ENSP00000392896.

    PTM databases

    PhosphoSitei O75506.

    Proteomic databases

    MaxQBi O75506.
    PaxDbi O75506.
    PRIDEi O75506.

    Protocols and materials databases

    DNASUi 3281.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000433866 ; ENSP00000392896 ; ENSG00000230989 .
    ENST00000570259 ; ENSP00000458007 ; ENSG00000230989 .
    GeneIDi 3281.
    KEGGi hsa:3281.
    UCSCi uc002fgy.2. human.

    Organism-specific databases

    CTDi 3281.
    GeneCardsi GC16P083841.
    HGNCi HGNC:5203. HSBP1.
    HPAi HPA028940.
    MIMi 604553. gene.
    neXtProti NX_O75506.
    PharmGKBi PA29475.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG317556.
    HOGENOMi HOG000217518.
    HOVERGENi HBG051930.
    InParanoidi O75506.
    OMAi PRKEINE.
    OrthoDBi EOG754HS8.
    PhylomeDBi O75506.
    TreeFami TF314005.

    Enzyme and pathway databases

    Reactomei REACT_200624. Attenuation phase.
    REACT_200744. HSF1 activation.
    REACT_200775. HSF1-dependent transactivation.

    Miscellaneous databases

    EvolutionaryTracei O75506.
    GenomeRNAii 3281.
    NextBioi 13027.
    PROi O75506.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O75506.
    Bgeei O75506.
    CleanExi HS_HSBP1.
    Genevestigatori O75506.

    Family and domain databases

    InterProi IPR009643. HS1-bd.
    [Graphical view ]
    PANTHERi PTHR19424. PTHR19424. 1 hit.
    Pfami PF06825. HSBP1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Negative regulation of the heat shock transcriptional response by HSBP1."
      Satyal S.H., Chen D., Fox S.G., Kramer J.M., Morimoto R.I.
      Genes Dev. 12:1962-1974(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], MUTAGENESIS.
    2. "Construction of cDNA expression library from nasopharyngeal carcinoma tissue and screening of antigenic genes."
      Shu J., Li G., He X.
      Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Fetal brain.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Muscle.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. "Crystal structure of the hexamer of human heat shock factor binding protein 1."
      Liu X., Xu L., Liu Y., Tong X., Zhu G., Zhang X.C., Li X., Rao Z.
      Proteins 75:1-11(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 6-53 OF MUTANT ILE-31 AND PRO-56, SUBUNIT.

    Entry informationi

    Entry nameiHSBP1_HUMAN
    AccessioniPrimary (citable) accession number: O75506
    Secondary accession number(s): Q53XA8, Q7Z5Z3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3