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Protein

Heat shock factor-binding protein 1

Gene

HSBP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process.

GO - Molecular functioni

  • transcription corepressor activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-3371511. HSF1 activation.
R-HSA-3371568. Attenuation phase.
R-HSA-3371571. HSF1-dependent transactivation.

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock factor-binding protein 1
Alternative name(s):
Nasopharyngeal carcinoma-associated antigen 13
Short name:
NPC-A-13
Gene namesi
Name:HSBP1
Synonyms:HSF1BP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:5203. HSBP1.

Subcellular locationi

GO - Cellular componenti

  • cytoskeleton Source: Ensembl
  • nucleoplasm Source: Reactome
  • nucleus Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi16V → K: Loss of interaction with HSF1; in association with K-19. 1 Publication1
Mutagenesisi19L → K: Loss of interaction with HSF1; in association with K-16. 1 Publication1
Mutagenesisi45I → K: Loss of interaction with HSF1; in association with K-48. 1 Publication1
Mutagenesisi48L → K: Loss of interaction with HSF1; in association with K-45. 1 Publication1

Organism-specific databases

DisGeNETi3281.
OpenTargetsiENSG00000230989.
PharmGKBiPA29475.

Polymorphism and mutation databases

BioMutaiHSBP1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001248051 – 76Heat shock factor-binding protein 1Add BLAST76

Proteomic databases

EPDiO75506.
MaxQBiO75506.
PaxDbiO75506.
PeptideAtlasiO75506.
PRIDEiO75506.
TopDownProteomicsiO75506.

PTM databases

iPTMnetiO75506.
PhosphoSitePlusiO75506.

Expressioni

Gene expression databases

BgeeiENSG00000230989.
CleanExiHS_HSBP1.
ExpressionAtlasiO75506. baseline and differential.
GenevisibleiO75506. HS.

Organism-specific databases

HPAiHPA028940.

Interactioni

Subunit structurei

Homohexamer. Associates with heptad repeats of HSF1 trimers and problaby also HSF1 monomers, and with HSP70. Association with HSF1 trimers and HSP70 coincides with attenuation of heat shock response and the conversion of HSF1 trimer to monomer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-748664,EBI-748664
CCDC53Q9Y3C010EBI-748664,EBI-712969
CCHCR1Q8TD31-37EBI-748664,EBI-10175300
KIAA1217Q5T5P2-65EBI-748664,EBI-10188326
KIFC3F5H3M24EBI-748664,EBI-11953930
KIFC3Q9BVG85EBI-748664,EBI-2125614
KRTAP10-7P604093EBI-748664,EBI-10172290
LNX1Q8TBB15EBI-748664,EBI-739832
NOTCH2NLQ7Z3S93EBI-748664,EBI-945833
SDCBPO005609EBI-748664,EBI-727004

Protein-protein interaction databases

BioGridi109515. 23 interactors.
IntActiO75506. 18 interactors.
MINTiMINT-1455497.
STRINGi9606.ENSP00000392896.

Structurei

Secondary structure

176
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi9 – 46Combined sources38

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3CI9X-ray1.80A/B6-53[»]
ProteinModelPortaliO75506.
SMRiO75506.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO75506.

Family & Domainsi

Sequence similaritiesi

Belongs to the HSBP1 family.Curated

Phylogenomic databases

eggNOGiKOG4117. Eukaryota.
ENOG41122JH. LUCA.
GeneTreeiENSGT00390000006293.
HOGENOMiHOG000217518.
HOVERGENiHBG051930.
InParanoidiO75506.
KOiK19765.
OMAiRIDEMGN.
OrthoDBiEOG091G14ZN.
PhylomeDBiO75506.
TreeFamiTF314005.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR012351. 4_helix_cytokine_core.
IPR009643. HS1-bd.
[Graphical view]
PANTHERiPTHR19424. PTHR19424. 1 hit.
PfamiPF06825. HSBP1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O75506-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAETDPKTVQ DLTSVVQTLL QQMQDKFQTM SDQIIGRIDD MSSRIDDLEK
60 70
NIADLMTQAG VEELESENKI PATQKS
Length:76
Mass (Da):8,544
Last modified:November 1, 1998 - v1
Checksum:i9838423C86B2D402
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti31S → A in AAP73809 (Ref. 2) Curated1
Sequence conflicti72A → V in AAP73809 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF068754 mRNA. Translation: AAC25186.1.
AY320409 mRNA. Translation: AAP73809.1.
BX537440 mRNA. Translation: CAD97682.1.
BC007515 mRNA. Translation: AAH07515.1.
CCDSiCCDS45534.1.
RefSeqiNP_001528.1. NM_001537.3.
UniGeneiHs.250899.

Genome annotation databases

EnsembliENST00000433866; ENSP00000392896; ENSG00000230989.
ENST00000570259; ENSP00000458007; ENSG00000230989.
GeneIDi3281.
KEGGihsa:3281.
UCSCiuc002fgy.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF068754 mRNA. Translation: AAC25186.1.
AY320409 mRNA. Translation: AAP73809.1.
BX537440 mRNA. Translation: CAD97682.1.
BC007515 mRNA. Translation: AAH07515.1.
CCDSiCCDS45534.1.
RefSeqiNP_001528.1. NM_001537.3.
UniGeneiHs.250899.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3CI9X-ray1.80A/B6-53[»]
ProteinModelPortaliO75506.
SMRiO75506.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109515. 23 interactors.
IntActiO75506. 18 interactors.
MINTiMINT-1455497.
STRINGi9606.ENSP00000392896.

PTM databases

iPTMnetiO75506.
PhosphoSitePlusiO75506.

Polymorphism and mutation databases

BioMutaiHSBP1.

Proteomic databases

EPDiO75506.
MaxQBiO75506.
PaxDbiO75506.
PeptideAtlasiO75506.
PRIDEiO75506.
TopDownProteomicsiO75506.

Protocols and materials databases

DNASUi3281.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000433866; ENSP00000392896; ENSG00000230989.
ENST00000570259; ENSP00000458007; ENSG00000230989.
GeneIDi3281.
KEGGihsa:3281.
UCSCiuc002fgy.3. human.

Organism-specific databases

CTDi3281.
DisGeNETi3281.
GeneCardsiHSBP1.
HGNCiHGNC:5203. HSBP1.
HPAiHPA028940.
MIMi604553. gene.
neXtProtiNX_O75506.
OpenTargetsiENSG00000230989.
PharmGKBiPA29475.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4117. Eukaryota.
ENOG41122JH. LUCA.
GeneTreeiENSGT00390000006293.
HOGENOMiHOG000217518.
HOVERGENiHBG051930.
InParanoidiO75506.
KOiK19765.
OMAiRIDEMGN.
OrthoDBiEOG091G14ZN.
PhylomeDBiO75506.
TreeFamiTF314005.

Enzyme and pathway databases

ReactomeiR-HSA-3371511. HSF1 activation.
R-HSA-3371568. Attenuation phase.
R-HSA-3371571. HSF1-dependent transactivation.

Miscellaneous databases

ChiTaRSiHSBP1. human.
EvolutionaryTraceiO75506.
GenomeRNAii3281.
PROiO75506.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000230989.
CleanExiHS_HSBP1.
ExpressionAtlasiO75506. baseline and differential.
GenevisibleiO75506. HS.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR012351. 4_helix_cytokine_core.
IPR009643. HS1-bd.
[Graphical view]
PANTHERiPTHR19424. PTHR19424. 1 hit.
PfamiPF06825. HSBP1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHSBP1_HUMAN
AccessioniPrimary (citable) accession number: O75506
Secondary accession number(s): Q53XA8, Q7Z5Z3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.