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Protein

Serine/arginine-rich splicing factor 10

Gene

SRSF10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing (PubMed:11684676, PubMed:12419250, PubMed:14765198). Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70 (PubMed:14765198). Required for splicing repression in M-phase cells and after heat shock (PubMed:14765198). Also acts as a splicing factor that specifically promotes exon skipping during alternative splicing (PubMed:26876937). Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator (PubMed:12419250).4 Publications

GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • RS domain binding Source: UniProtKB
  • unfolded protein binding Source: UniProtKB

GO - Biological processi

  • cytosolic transport Source: Ensembl
  • mRNA splice site selection Source: UniProtKB
  • mRNA splicing, via spliceosome Source: UniProtKB
  • negative regulation of mRNA splicing, via spliceosome Source: UniProtKB
  • regulation of mRNA splicing, via spliceosome Source: UniProtKB
  • regulation of transcription, DNA-templated Source: UniProtKB
  • RNA splicing, via transesterification reactions Source: UniProtKB
  • spliceosomal tri-snRNP complex assembly Source: UniProtKB

Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-HSA-72163 mRNA Splicing - Major Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/arginine-rich splicing factor 10
Alternative name(s):
40 kDa SR-repressor protein
Short name:
SRrp40
FUS-interacting serine-arginine-rich protein 1
Splicing factor SRp38
Splicing factor, arginine/serine-rich 13A
TLS-associated protein with Ser-Arg repeats
Short name:
TASR
Short name:
TLS-associated protein with SR repeats
TLS-associated serine-arginine protein
Short name:
TLS-associated SR protein
Gene namesi
Name:SRSF10
Synonyms:FUSIP1, FUSIP2, SFRS13A, TASR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000188529.14
HGNCiHGNC:16713 SRSF10
MIMi605221 gene
neXtProtiNX_O75494

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10772
OpenTargetsiENSG00000188529
PharmGKBiPA28427

Polymorphism and mutation databases

BioMutaiSRSF10

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000815931 – 262Serine/arginine-rich splicing factor 10Add BLAST262

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei23PhosphoserineCombined sources1
Modified residuei106PhosphoserineCombined sources1
Modified residuei108PhosphoserineCombined sources1
Modified residuei129PhosphoserineCombined sources1
Modified residuei131PhosphoserineCombined sources1
Modified residuei133PhosphoserineCombined sources1
Modified residuei158PhosphoserineCombined sources1
Modified residuei160PhosphoserineCombined sources1
Isoform 4 (identifier: O75494-4)
Modified residuei158PhosphoserineCombined sources1
Modified residuei160PhosphoserineCombined sources1
Isoform 3 (identifier: O75494-3)
Modified residuei168PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated. Fully dephosphorylated in mitosis and partially dephosphorylated on heat shock.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO75494
MaxQBiO75494
PaxDbiO75494
PeptideAtlasiO75494
PRIDEiO75494
TopDownProteomicsiO75494-1 [O75494-1]
O75494-2 [O75494-2]
O75494-3 [O75494-3]
O75494-4 [O75494-4]
O75494-5 [O75494-5]

PTM databases

iPTMnetiO75494
PhosphoSitePlusiO75494
SwissPalmiO75494

Expressioni

Tissue specificityi

Widely expressed.2 Publications

Gene expression databases

BgeeiENSG00000188529
ExpressionAtlasiO75494 baseline and differential
GenevisibleiO75494 HS

Organism-specific databases

HPAiHPA053805
HPA053831

Interactioni

Subunit structurei

The phosphorylated but not the dephosphorylated form interacts with TRA2B/SFRS10 (PubMed:14765198). The dephosphorylated form interacts with SNRNP70 (PubMed:14765198). Isoform 1 interacts with FUS C-terminus (PubMed:9774382). Isoform 3 interacts with FUS C-terminus (PubMed:9774382). Interacts with YTHDC1, leading to inhibit RNA-binding activity of SRSF10 (PubMed:26876937).3 Publications

GO - Molecular functioni

  • RS domain binding Source: UniProtKB
  • unfolded protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi115990, 84 interactors
IntActiO75494, 33 interactors
MINTiO75494
STRINGi9606.ENSP00000420195

Structurei

3D structure databases

ProteinModelPortaliO75494
SMRiO75494
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 88RRMPROSITE-ProRule annotationAdd BLAST79

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi106 – 260Arg/Ser-rich (RS domain)Add BLAST155

Sequence similaritiesi

Belongs to the splicing factor SR family.Curated

Phylogenomic databases

eggNOGiKOG0118 Eukaryota
COG0724 LUCA
GeneTreeiENSGT00700000104403
HOGENOMiHOG000276233
HOVERGENiHBG107480
InParanoidiO75494
KOiK12900
OMAiFAYVQYT
OrthoDBiEOG091G13K0
PhylomeDBiO75494
TreeFamiTF351864

Family and domain databases

Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR034476 SRSF10
PANTHERiPTHR23147:SF5 PTHR23147:SF5, 1 hit
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75494-1) [UniParc]FASTAAdd to basket
Also known as: TASR-1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRYLRPPNT SLFVRNVADD TRSEDLRREF GRYGPIVDVY VPLDFYTRRP
60 70 80 90 100
RGFAYVQFED VRDAEDALHN LDRKWICGRQ IEIQFAQGDR KTPNQMKAKE
110 120 130 140 150
GRNVYSSSRY DDYDRYRRSR SRSYERRRSR SRSFDYNYRR SYSPRNSRPT
160 170 180 190 200
GRPRRSRSHS DNDRFKHRNR SFSRSKSNSR SRSKSQPKKE MKAKSRSRSA
210 220 230 240 250
SHTKTRGTSK TDSKTHYKSG SRYEKESRKK EPPRSKSQSR SQSRSRSKSR
260
SRSWTSPKSS GH
Length:262
Mass (Da):31,301
Last modified:November 1, 1998 - v1
Checksum:i205F95D36CBBFAB4
GO
Isoform 2 (identifier: O75494-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     147-147: Missing.

Show »
Length:261
Mass (Da):31,213
Checksum:iA07499B11D4C7570
GO
Isoform 3 (identifier: O75494-3) [UniParc]FASTAAdd to basket
Also known as: TASR-2, SRp38-2

The sequence of this isoform differs from the canonical sequence as follows:
     165-183: FKHRNRSFSRSKSNSRSRS → PNCSWNTQYSSAYYTSRKI
     184-262: Missing.

Show »
Length:183
Mass (Da):22,222
Checksum:i4AA87CAA9B51A131
GO
Isoform 4 (identifier: O75494-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     164-173: RFKHRNRSFS → SQVSKKKNER
     174-183: Missing.
     184-262: Missing.

Show »
Length:173
Mass (Da):21,000
Checksum:i4AB40FBF24846495
GO
Isoform 5 (identifier: O75494-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     146-165: NSRPTGRPRRSRSHSDNDRF → KPNCSWNTQYSSAYYTSRKI
     166-173: Missing.
     174-183: Missing.
     184-262: Missing.

Note: No experimental confirmation available.
Show »
Length:165
Mass (Da):20,117
Checksum:i6CB98688C53A9F69
GO
Isoform 6 (identifier: O75494-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     147-147: Missing.
     165-183: FKHRNRSFSRSKSNSRSRS → PNCSWNTQYSSAYYTSRKI
     184-262: Missing.

Note: No experimental confirmation available.
Show »
Length:182
Mass (Da):22,135
Checksum:iF99356E1D895987D
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_043697146 – 165NSRPT…DNDRF → KPNCSWNTQYSSAYYTSRKI in isoform 5. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_010421147Missing in isoform 2 and isoform 6. 1 Publication1
Alternative sequenceiVSP_010422164 – 173RFKHRNRSFS → SQVSKKKNER in isoform 4. Curated10
Alternative sequenceiVSP_010424165 – 183FKHRN…SRSRS → PNCSWNTQYSSAYYTSRKI in isoform 3 and isoform 6. 4 PublicationsAdd BLAST19
Alternative sequenceiVSP_043698166 – 173Missing in isoform 5. 1 Publication8
Alternative sequenceiVSP_010423174 – 183Missing in isoform 4 and isoform 5. 1 Publication10
Alternative sequenceiVSP_010425184 – 262Missing in isoform 3, isoform 4, isoform 5 and isoform 6. 4 PublicationsAdd BLAST79

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047448 mRNA Translation: AAC70918.1
AF067730 mRNA Translation: AAC26727.1
AF449427 mRNA Translation: AAL57514.1
AY150180 mRNA Translation: AAN65380.1
AY150181 mRNA Translation: AAN65381.1
AF419331 mRNA Translation: AAL16665.1
AF419332 Genomic DNA Translation: AAL16666.1
AY048592 Genomic DNA Translation: AAL06098.1
AY048592 Genomic DNA Translation: AAL06099.1
AK001286 mRNA Translation: BAA91601.1
AK001656 mRNA Translation: BAG50956.1
AK296175 mRNA Translation: BAG58911.1
AL590609 Genomic DNA No translation available.
BC001107 mRNA Translation: AAH01107.1
BC005039 mRNA Translation: AAH05039.1
BC010074 mRNA Translation: AAH10074.1
CCDSiCCDS30629.1 [O75494-3]
CCDS30630.1 [O75494-1]
CCDS53280.1 [O75494-5]
CCDS53281.1 [O75494-6]
CCDS53282.1 [O75494-2]
CCDS53283.1 [O75494-4]
RefSeqiNP_001177934.1, NM_001191005.2 [O75494-2]
NP_001177935.1, NM_001191006.2 [O75494-4]
NP_001177936.1, NM_001191007.2 [O75494-6]
NP_001177938.1, NM_001191009.2 [O75494-5]
NP_006616.1, NM_006625.5 [O75494-3]
NP_473357.1, NM_054016.3 [O75494-1]
UniGeneiHs.3530

Genome annotation databases

EnsembliENST00000343255; ENSP00000344149; ENSG00000188529 [O75494-2]
ENST00000344989; ENSP00000342913; ENSG00000188529 [O75494-3]
ENST00000374452; ENSP00000363576; ENSG00000188529 [O75494-4]
ENST00000453840; ENSP00000388991; ENSG00000188529 [O75494-6]
ENST00000484146; ENSP00000419813; ENSG00000188529 [O75494-5]
ENST00000492112; ENSP00000420195; ENSG00000188529 [O75494-1]
GeneIDi10772
KEGGihsa:10772
UCSCiuc057dhz.1 human [O75494-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSRS10_HUMAN
AccessioniPrimary (citable) accession number: O75494
Secondary accession number(s): A6NFM6
, A6NI42, A6NIU7, B4DJP9, O60572, Q5JRH9, Q5JRI0, Q5JRI2, Q5JRI3, Q5JRI4, Q96G09, Q96P17
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 181 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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