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O75493

- CAH11_HUMAN

UniProt

O75493 - CAH11_HUMAN

Protein

Carbonic anhydrase-related protein 11

Gene

CA11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 2 (01 Dec 2000)
      Previous versions | rss
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    Functioni

    Does not have a catalytic activity.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Carbonic anhydrase-related protein 11
    Alternative name(s):
    CA-RP XI
    Short name:
    CA-XI
    Short name:
    CARP XI
    Carbonic anhydrase-related protein 2
    Short name:
    CA-RP II
    Short name:
    CARP-2
    Gene namesi
    Name:CA11
    Synonyms:CARP2
    ORF Names:UNQ211/PRO237
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:1370. CA11.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. basolateral plasma membrane Source: Ensembl
    2. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25986.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 328305Carbonic anhydrase-related protein 11PRO_0000004245Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi118 – 1181N-linked (GlcNAc...)1 Publication
    Glycosylationi170 – 1701N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi260 – 2601N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiO75493.
    PRIDEiO75493.

    PTM databases

    PhosphoSiteiO75493.

    Expressioni

    Tissue specificityi

    Expressed abundantly in the brain with moderate expression also present in spinal cord and thyroid.

    Gene expression databases

    BgeeiO75493.
    CleanExiHS_CA11.
    GenevestigatoriO75493.

    Organism-specific databases

    HPAiHPA041778.

    Interactioni

    Protein-protein interaction databases

    BioGridi107224. 1 interaction.
    STRINGi9606.ENSP00000084798.

    Structurei

    3D structure databases

    ProteinModelPortaliO75493.
    SMRiO75493. Positions 63-302.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alpha-carbonic anhydrase family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG3338.
    HOGENOMiHOG000019899.
    HOVERGENiHBG097666.
    InParanoidiO75493.
    OMAiYKENLQG.
    OrthoDBiEOG7M98HZ.
    PhylomeDBiO75493.
    TreeFamiTF352926.

    Family and domain databases

    Gene3Di3.10.200.10. 1 hit.
    InterProiIPR001148. Carbonic_anhydrase_a.
    IPR023561. Carbonic_anhydrase_a-class.
    [Graphical view]
    PANTHERiPTHR18952. PTHR18952. 1 hit.
    PfamiPF00194. Carb_anhydrase. 1 hit.
    [Graphical view]
    SMARTiSM01057. Carb_anhydrase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51069. SSF51069. 1 hit.
    PROSITEiPS51144. ALPHA_CA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O75493-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGAAARLSAP RALVLWAALG AAAHIGPAPD PEDWWSYKDN LQGNFVPGPP    50
    FWGLVNAAWS LCAVGKRQSP VDVELKRVLY DPFLPPLRLS TGGEKLRGTL 100
    YNTGRHVSFL PAPRPVVNVS GGPLLYSHRL SELRLLFGAR DGAGSEHQIN 150
    HQGFSAEVQL IHFNQELYGN FSAASRGPNG LAILSLFVNV ASTSNPFLSR 200
    LLNRDTITRI SYKNDAYFLQ DLSLELLFPE SFGFITYQGS LSTPPCSETV 250
    TWILIDRALN ITSLQMHSLR LLSQNPPSQI FQSLSGNSRP LQPLAHRALR 300
    GNRDPRHPER RCRGPNYRLH VDGVPHGR 328
    Length:328
    Mass (Da):36,238
    Last modified:December 1, 2000 - v2
    Checksum:iA4FC408718B2E857
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti23 – 242AH → GN in BAA36840. (PubMed:10350627)Curated
    Sequence conflicti75 – 751L → V in AAC99689. (PubMed:9878543)Curated
    Sequence conflicti280 – 2801I → M in AAD08802. (PubMed:9878252)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF067662 mRNA. Translation: AAC99689.1.
    AB018195 mRNA. Translation: BAA36840.1.
    AY358967 mRNA. Translation: AAQ89326.1.
    CR541772 mRNA. Translation: CAG46571.1.
    BT007265 mRNA. Translation: AAP35929.1.
    BC002662 mRNA. Translation: AAH02662.1.
    AF050106 mRNA. Translation: AAD08802.1.
    CCDSiCCDS12729.1.
    PIRiJE0375.
    RefSeqiNP_001208.2. NM_001217.3.
    UniGeneiHs.428446.

    Genome annotation databases

    EnsembliENST00000084798; ENSP00000084798; ENSG00000063180.
    GeneIDi770.
    KEGGihsa:770.
    UCSCiuc002pjz.1. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF067662 mRNA. Translation: AAC99689.1 .
    AB018195 mRNA. Translation: BAA36840.1 .
    AY358967 mRNA. Translation: AAQ89326.1 .
    CR541772 mRNA. Translation: CAG46571.1 .
    BT007265 mRNA. Translation: AAP35929.1 .
    BC002662 mRNA. Translation: AAH02662.1 .
    AF050106 mRNA. Translation: AAD08802.1 .
    CCDSi CCDS12729.1.
    PIRi JE0375.
    RefSeqi NP_001208.2. NM_001217.3.
    UniGenei Hs.428446.

    3D structure databases

    ProteinModelPortali O75493.
    SMRi O75493. Positions 63-302.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107224. 1 interaction.
    STRINGi 9606.ENSP00000084798.

    Chemistry

    BindingDBi O75493.
    ChEMBLi CHEMBL2420.

    PTM databases

    PhosphoSitei O75493.

    Proteomic databases

    PaxDbi O75493.
    PRIDEi O75493.

    Protocols and materials databases

    DNASUi 770.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000084798 ; ENSP00000084798 ; ENSG00000063180 .
    GeneIDi 770.
    KEGGi hsa:770.
    UCSCi uc002pjz.1. human.

    Organism-specific databases

    CTDi 770.
    GeneCardsi GC19M049141.
    HGNCi HGNC:1370. CA11.
    HPAi HPA041778.
    MIMi 604644. gene.
    neXtProti NX_O75493.
    PharmGKBi PA25986.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG3338.
    HOGENOMi HOG000019899.
    HOVERGENi HBG097666.
    InParanoidi O75493.
    OMAi YKENLQG.
    OrthoDBi EOG7M98HZ.
    PhylomeDBi O75493.
    TreeFami TF352926.

    Miscellaneous databases

    GeneWikii CA11.
    GenomeRNAii 770.
    NextBioi 3110.
    PROi O75493.
    SOURCEi Search...

    Gene expression databases

    Bgeei O75493.
    CleanExi HS_CA11.
    Genevestigatori O75493.

    Family and domain databases

    Gene3Di 3.10.200.10. 1 hit.
    InterProi IPR001148. Carbonic_anhydrase_a.
    IPR023561. Carbonic_anhydrase_a-class.
    [Graphical view ]
    PANTHERi PTHR18952. PTHR18952. 1 hit.
    Pfami PF00194. Carb_anhydrase. 1 hit.
    [Graphical view ]
    SMARTi SM01057. Carb_anhydrase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51069. SSF51069. 1 hit.
    PROSITEi PS51144. ALPHA_CA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and tissue expression of a novel human carbonic anhydrase-related protein, CARP-2, mapping to chromosome 19q13.3."
      Bellingham J., Gregory-Evans K., Gregory-Evans C.Y.
      Biochem. Biophys. Res. Commun. 253:364-367(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "cDNA sequence, mRNA expression, and chromosomal localization of human carbonic anhydrase-related protein, CA-RP XI."
      Fujikawa-Adachi K., Nishimori I., Taguchi T., Yuri K., Onishi S.
      Biochim. Biophys. Acta 1431:518-524(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Pancreas.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Uterus.
    7. "Evolutionarily conserved, 'acatalytic' carbonic anhydrase-related protein XI contains a sequence motif present in the neuropeptide sauvagine: the human CA-RP XI gene (CA11) is embedded between the secretor gene cluster and the DBP gene at 19q13.3."
      Lovejoy D.A., Hewett-Emmett D., Porter C.A., Cepoi D., Sheffield A., Vale W.W., Tashian R.E.
      Genomics 54:484-493(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 48-314.
      Tissue: Brain.
    8. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
      J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-118.
      Tissue: Plasma.

    Entry informationi

    Entry nameiCAH11_HUMAN
    AccessioniPrimary (citable) accession number: O75493
    Secondary accession number(s): O60596, Q6FHI1, Q9UEC4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: December 1, 2000
    Last modified: October 1, 2014
    This is version 122 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3