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O75493 (CAH11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Carbonic anhydrase-related protein 11
Alternative name(s):
CA-RP XI
Short name=CA-XI
Short name=CARP XI
Carbonic anhydrase-related protein 2
Short name=CA-RP II
Short name=CARP-2
Gene names
Name:CA11
Synonyms:CARP2
ORF Names:UNQ211/PRO237
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length328 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Does not have a catalytic activity.

Subcellular location

Secreted Potential.

Tissue specificity

Expressed abundantly in the brain with moderate expression also present in spinal cord and thyroid.

Sequence similarities

Belongs to the alpha-carbonic anhydrase family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentbasolateral plasma membrane

Inferred from electronic annotation. Source: Ensembl

extracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 328305Carbonic anhydrase-related protein 11
PRO_0000004245

Amino acid modifications

Glycosylation1181N-linked (GlcNAc...) Ref.8
Glycosylation1701N-linked (GlcNAc...) Potential
Glycosylation2601N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict23 – 242AH → GN in BAA36840. Ref.2
Sequence conflict751L → V in AAC99689. Ref.1
Sequence conflict2801I → M in AAD08802. Ref.7

Sequences

Sequence LengthMass (Da)Tools
O75493 [UniParc].

Last modified December 1, 2000. Version 2.
Checksum: A4FC408718B2E857

FASTA32836,238
        10         20         30         40         50         60 
MGAAARLSAP RALVLWAALG AAAHIGPAPD PEDWWSYKDN LQGNFVPGPP FWGLVNAAWS 

        70         80         90        100        110        120 
LCAVGKRQSP VDVELKRVLY DPFLPPLRLS TGGEKLRGTL YNTGRHVSFL PAPRPVVNVS 

       130        140        150        160        170        180 
GGPLLYSHRL SELRLLFGAR DGAGSEHQIN HQGFSAEVQL IHFNQELYGN FSAASRGPNG 

       190        200        210        220        230        240 
LAILSLFVNV ASTSNPFLSR LLNRDTITRI SYKNDAYFLQ DLSLELLFPE SFGFITYQGS 

       250        260        270        280        290        300 
LSTPPCSETV TWILIDRALN ITSLQMHSLR LLSQNPPSQI FQSLSGNSRP LQPLAHRALR 

       310        320 
GNRDPRHPER RCRGPNYRLH VDGVPHGR 

« Hide

References

« Hide 'large scale' references
[1]"Sequence and tissue expression of a novel human carbonic anhydrase-related protein, CARP-2, mapping to chromosome 19q13.3."
Bellingham J., Gregory-Evans K., Gregory-Evans C.Y.
Biochem. Biophys. Res. Commun. 253:364-367(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"cDNA sequence, mRNA expression, and chromosomal localization of human carbonic anhydrase-related protein, CA-RP XI."
Fujikawa-Adachi K., Nishimori I., Taguchi T., Yuri K., Onishi S.
Biochim. Biophys. Acta 1431:518-524(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Pancreas.
[3]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Uterus.
[7]"Evolutionarily conserved, 'acatalytic' carbonic anhydrase-related protein XI contains a sequence motif present in the neuropeptide sauvagine: the human CA-RP XI gene (CA11) is embedded between the secretor gene cluster and the DBP gene at 19q13.3."
Lovejoy D.A., Hewett-Emmett D., Porter C.A., Cepoi D., Sheffield A., Vale W.W., Tashian R.E.
Genomics 54:484-493(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 48-314.
Tissue: Brain.
[8]"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-118.
Tissue: Plasma.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF067662 mRNA. Translation: AAC99689.1.
AB018195 mRNA. Translation: BAA36840.1.
AY358967 mRNA. Translation: AAQ89326.1.
CR541772 mRNA. Translation: CAG46571.1.
BT007265 mRNA. Translation: AAP35929.1.
BC002662 mRNA. Translation: AAH02662.1.
AF050106 mRNA. Translation: AAD08802.1.
PIRJE0375.
RefSeqNP_001208.2. NM_001217.3.
UniGeneHs.428446.

3D structure databases

ProteinModelPortalO75493.
SMRO75493. Positions 63-302.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107224. 1 interaction.
STRING9606.ENSP00000084798.

Chemistry

BindingDBO75493.
ChEMBLCHEMBL2420.

PTM databases

PhosphoSiteO75493.

Proteomic databases

PaxDbO75493.
PRIDEO75493.

Protocols and materials databases

DNASU770.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000084798; ENSP00000084798; ENSG00000063180.
GeneID770.
KEGGhsa:770.
UCSCuc002pjz.1. human.

Organism-specific databases

CTD770.
GeneCardsGC19M049141.
HGNCHGNC:1370. CA11.
HPAHPA041778.
MIM604644. gene.
neXtProtNX_O75493.
PharmGKBPA25986.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG3338.
HOGENOMHOG000019899.
HOVERGENHBG097666.
InParanoidO75493.
OMAEHQINHE.
OrthoDBEOG7M98HZ.
PhylomeDBO75493.
TreeFamTF352926.

Gene expression databases

BgeeO75493.
CleanExHS_CA11.
GenevestigatorO75493.

Family and domain databases

Gene3D3.10.200.10. 1 hit.
InterProIPR018423. CA10/11.
IPR001148. Carbonic_anhydrase_a.
IPR023561. Carbonic_anhydrase_a-class.
[Graphical view]
PANTHERPTHR18952. PTHR18952. 1 hit.
PTHR18952:SF11. PTHR18952:SF11. 1 hit.
PfamPF00194. Carb_anhydrase. 1 hit.
[Graphical view]
SMARTSM01057. Carb_anhydrase. 1 hit.
[Graphical view]
SUPFAMSSF51069. SSF51069. 1 hit.
PROSITEPS51144. ALPHA_CA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiCA11.
GenomeRNAi770.
NextBio3110.
PROO75493.
SOURCESearch...

Entry information

Entry nameCAH11_HUMAN
AccessionPrimary (citable) accession number: O75493
Secondary accession number(s): O60596, Q6FHI1, Q9UEC4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: December 1, 2000
Last modified: March 19, 2014
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM