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O75493

- CAH11_HUMAN

UniProt

O75493 - CAH11_HUMAN

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Protein

Carbonic anhydrase-related protein 11

Gene

CA11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Does not have a catalytic activity.

Names & Taxonomyi

Protein namesi
Recommended name:
Carbonic anhydrase-related protein 11
Alternative name(s):
CA-RP XI
Short name:
CA-XI
Short name:
CARP XI
Carbonic anhydrase-related protein 2
Short name:
CA-RP II
Short name:
CARP-2
Gene namesi
Name:CA11
Synonyms:CARP2
ORF Names:UNQ211/PRO237
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:1370. CA11.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. basolateral plasma membrane Source: Ensembl
  2. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25986.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 328305Carbonic anhydrase-related protein 11PRO_0000004245Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi118 – 1181N-linked (GlcNAc...)1 Publication
Glycosylationi170 – 1701N-linked (GlcNAc...)Sequence Analysis
Glycosylationi260 – 2601N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO75493.
PRIDEiO75493.

PTM databases

PhosphoSiteiO75493.

Expressioni

Tissue specificityi

Expressed abundantly in the brain with moderate expression also present in spinal cord and thyroid.

Gene expression databases

BgeeiO75493.
CleanExiHS_CA11.
GenevestigatoriO75493.

Organism-specific databases

HPAiHPA041778.

Interactioni

Protein-protein interaction databases

BioGridi107224. 5 interactions.
STRINGi9606.ENSP00000084798.

Structurei

3D structure databases

ProteinModelPortaliO75493.
SMRiO75493. Positions 63-302.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha-carbonic anhydrase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG3338.
GeneTreeiENSGT00740000115510.
HOGENOMiHOG000019899.
HOVERGENiHBG097666.
InParanoidiO75493.
OMAiYKENLQG.
OrthoDBiEOG7M98HZ.
PhylomeDBiO75493.
TreeFamiTF352926.

Family and domain databases

Gene3Di3.10.200.10. 1 hit.
InterProiIPR001148. Carbonic_anhydrase_a.
IPR023561. Carbonic_anhydrase_a-class.
[Graphical view]
PANTHERiPTHR18952. PTHR18952. 1 hit.
PfamiPF00194. Carb_anhydrase. 1 hit.
[Graphical view]
SMARTiSM01057. Carb_anhydrase. 1 hit.
[Graphical view]
SUPFAMiSSF51069. SSF51069. 1 hit.
PROSITEiPS51144. ALPHA_CA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O75493-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGAAARLSAP RALVLWAALG AAAHIGPAPD PEDWWSYKDN LQGNFVPGPP
60 70 80 90 100
FWGLVNAAWS LCAVGKRQSP VDVELKRVLY DPFLPPLRLS TGGEKLRGTL
110 120 130 140 150
YNTGRHVSFL PAPRPVVNVS GGPLLYSHRL SELRLLFGAR DGAGSEHQIN
160 170 180 190 200
HQGFSAEVQL IHFNQELYGN FSAASRGPNG LAILSLFVNV ASTSNPFLSR
210 220 230 240 250
LLNRDTITRI SYKNDAYFLQ DLSLELLFPE SFGFITYQGS LSTPPCSETV
260 270 280 290 300
TWILIDRALN ITSLQMHSLR LLSQNPPSQI FQSLSGNSRP LQPLAHRALR
310 320
GNRDPRHPER RCRGPNYRLH VDGVPHGR
Length:328
Mass (Da):36,238
Last modified:December 1, 2000 - v2
Checksum:iA4FC408718B2E857
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti23 – 242AH → GN in BAA36840. (PubMed:10350627)Curated
Sequence conflicti75 – 751L → V in AAC99689. (PubMed:9878543)Curated
Sequence conflicti280 – 2801I → M in AAD08802. (PubMed:9878252)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF067662 mRNA. Translation: AAC99689.1.
AB018195 mRNA. Translation: BAA36840.1.
AY358967 mRNA. Translation: AAQ89326.1.
CR541772 mRNA. Translation: CAG46571.1.
BT007265 mRNA. Translation: AAP35929.1.
BC002662 mRNA. Translation: AAH02662.1.
AF050106 mRNA. Translation: AAD08802.1.
CCDSiCCDS12729.1.
PIRiJE0375.
RefSeqiNP_001208.2. NM_001217.3.
UniGeneiHs.428446.

Genome annotation databases

EnsembliENST00000084798; ENSP00000084798; ENSG00000063180.
GeneIDi770.
KEGGihsa:770.
UCSCiuc002pjz.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF067662 mRNA. Translation: AAC99689.1 .
AB018195 mRNA. Translation: BAA36840.1 .
AY358967 mRNA. Translation: AAQ89326.1 .
CR541772 mRNA. Translation: CAG46571.1 .
BT007265 mRNA. Translation: AAP35929.1 .
BC002662 mRNA. Translation: AAH02662.1 .
AF050106 mRNA. Translation: AAD08802.1 .
CCDSi CCDS12729.1.
PIRi JE0375.
RefSeqi NP_001208.2. NM_001217.3.
UniGenei Hs.428446.

3D structure databases

ProteinModelPortali O75493.
SMRi O75493. Positions 63-302.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107224. 5 interactions.
STRINGi 9606.ENSP00000084798.

Chemistry

BindingDBi O75493.
ChEMBLi CHEMBL2420.
DrugBanki DB00909. Zonisamide.

PTM databases

PhosphoSitei O75493.

Proteomic databases

PaxDbi O75493.
PRIDEi O75493.

Protocols and materials databases

DNASUi 770.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000084798 ; ENSP00000084798 ; ENSG00000063180 .
GeneIDi 770.
KEGGi hsa:770.
UCSCi uc002pjz.1. human.

Organism-specific databases

CTDi 770.
GeneCardsi GC19M049141.
HGNCi HGNC:1370. CA11.
HPAi HPA041778.
MIMi 604644. gene.
neXtProti NX_O75493.
PharmGKBi PA25986.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG3338.
GeneTreei ENSGT00740000115510.
HOGENOMi HOG000019899.
HOVERGENi HBG097666.
InParanoidi O75493.
OMAi YKENLQG.
OrthoDBi EOG7M98HZ.
PhylomeDBi O75493.
TreeFami TF352926.

Miscellaneous databases

GeneWikii CA11.
GenomeRNAii 770.
NextBioi 3110.
PROi O75493.
SOURCEi Search...

Gene expression databases

Bgeei O75493.
CleanExi HS_CA11.
Genevestigatori O75493.

Family and domain databases

Gene3Di 3.10.200.10. 1 hit.
InterProi IPR001148. Carbonic_anhydrase_a.
IPR023561. Carbonic_anhydrase_a-class.
[Graphical view ]
PANTHERi PTHR18952. PTHR18952. 1 hit.
Pfami PF00194. Carb_anhydrase. 1 hit.
[Graphical view ]
SMARTi SM01057. Carb_anhydrase. 1 hit.
[Graphical view ]
SUPFAMi SSF51069. SSF51069. 1 hit.
PROSITEi PS51144. ALPHA_CA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and tissue expression of a novel human carbonic anhydrase-related protein, CARP-2, mapping to chromosome 19q13.3."
    Bellingham J., Gregory-Evans K., Gregory-Evans C.Y.
    Biochem. Biophys. Res. Commun. 253:364-367(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "cDNA sequence, mRNA expression, and chromosomal localization of human carbonic anhydrase-related protein, CA-RP XI."
    Fujikawa-Adachi K., Nishimori I., Taguchi T., Yuri K., Onishi S.
    Biochim. Biophys. Acta 1431:518-524(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pancreas.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  7. "Evolutionarily conserved, 'acatalytic' carbonic anhydrase-related protein XI contains a sequence motif present in the neuropeptide sauvagine: the human CA-RP XI gene (CA11) is embedded between the secretor gene cluster and the DBP gene at 19q13.3."
    Lovejoy D.A., Hewett-Emmett D., Porter C.A., Cepoi D., Sheffield A., Vale W.W., Tashian R.E.
    Genomics 54:484-493(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 48-314.
    Tissue: Brain.
  8. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-118.
    Tissue: Plasma.

Entry informationi

Entry nameiCAH11_HUMAN
AccessioniPrimary (citable) accession number: O75493
Secondary accession number(s): O60596, Q6FHI1, Q9UEC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: December 1, 2000
Last modified: October 29, 2014
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3