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Protein

Carbonic anhydrase-related protein 11

Gene

CA11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Does not have a catalytic activity.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000063180-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Carbonic anhydrase-related protein 11
Alternative name(s):
CA-RP XI
Short name:
CA-XI
Short name:
CARP XI
Carbonic anhydrase-related protein 2
Short name:
CA-RP II
Short name:
CARP-2
Gene namesi
Name:CA11
Synonyms:CARP2
ORF Names:UNQ211/PRO237
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:1370. CA11.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi770.
OpenTargetsiENSG00000063180.
PharmGKBiPA25986.

Chemistry databases

ChEMBLiCHEMBL2420.
DrugBankiDB00909. Zonisamide.

Polymorphism and mutation databases

BioMutaiCA11.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000000424524 – 328Carbonic anhydrase-related protein 11Add BLAST305

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi118N-linked (GlcNAc...)1 Publication1
Glycosylationi170N-linked (GlcNAc...)Sequence analysis1
Glycosylationi260N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO75493.
PeptideAtlasiO75493.
PRIDEiO75493.

PTM databases

iPTMnetiO75493.
PhosphoSitePlusiO75493.

Expressioni

Tissue specificityi

Expressed abundantly in the brain with moderate expression also present in spinal cord and thyroid.

Gene expression databases

BgeeiENSG00000063180.
CleanExiHS_CA11.
ExpressionAtlasiO75493. baseline and differential.
GenevisibleiO75493. HS.

Organism-specific databases

HPAiHPA041778.

Interactioni

Protein-protein interaction databases

BioGridi107224. 6 interactors.
STRINGi9606.ENSP00000084798.

Structurei

3D structure databases

ProteinModelPortaliO75493.
SMRiO75493.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 303Alpha-carbonic anhydrasePROSITE-ProRule annotationAdd BLAST271

Sequence similaritiesi

Belongs to the alpha-carbonic anhydrase family.Curated
Contains 1 alpha-carbonic anhydrase domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0382. Eukaryota.
COG3338. LUCA.
GeneTreeiENSGT00740000115510.
HOGENOMiHOG000019899.
HOVERGENiHBG097666.
InParanoidiO75493.
OMAiEHQINHE.
OrthoDBiEOG091G0T4J.
PhylomeDBiO75493.
TreeFamiTF352926.

Family and domain databases

Gene3Di3.10.200.10. 1 hit.
InterProiIPR001148. Carbonic_anhydrase_a.
IPR023561. Carbonic_anhydrase_a-class.
[Graphical view]
PANTHERiPTHR18952. PTHR18952. 1 hit.
PfamiPF00194. Carb_anhydrase. 1 hit.
[Graphical view]
SMARTiSM01057. Carb_anhydrase. 1 hit.
[Graphical view]
SUPFAMiSSF51069. SSF51069. 1 hit.
PROSITEiPS51144. ALPHA_CA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O75493-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAAARLSAP RALVLWAALG AAAHIGPAPD PEDWWSYKDN LQGNFVPGPP
60 70 80 90 100
FWGLVNAAWS LCAVGKRQSP VDVELKRVLY DPFLPPLRLS TGGEKLRGTL
110 120 130 140 150
YNTGRHVSFL PAPRPVVNVS GGPLLYSHRL SELRLLFGAR DGAGSEHQIN
160 170 180 190 200
HQGFSAEVQL IHFNQELYGN FSAASRGPNG LAILSLFVNV ASTSNPFLSR
210 220 230 240 250
LLNRDTITRI SYKNDAYFLQ DLSLELLFPE SFGFITYQGS LSTPPCSETV
260 270 280 290 300
TWILIDRALN ITSLQMHSLR LLSQNPPSQI FQSLSGNSRP LQPLAHRALR
310 320
GNRDPRHPER RCRGPNYRLH VDGVPHGR
Length:328
Mass (Da):36,238
Last modified:December 1, 2000 - v2
Checksum:iA4FC408718B2E857
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23 – 24AH → GN in BAA36840 (PubMed:10350627).Curated2
Sequence conflicti75L → V in AAC99689 (PubMed:9878543).Curated1
Sequence conflicti280I → M in AAD08802 (PubMed:9878252).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF067662 mRNA. Translation: AAC99689.1.
AB018195 mRNA. Translation: BAA36840.1.
AY358967 mRNA. Translation: AAQ89326.1.
CR541772 mRNA. Translation: CAG46571.1.
BT007265 mRNA. Translation: AAP35929.1.
BC002662 mRNA. Translation: AAH02662.1.
AF050106 mRNA. Translation: AAD08802.1.
CCDSiCCDS12729.1.
PIRiJE0375.
RefSeqiNP_001208.2. NM_001217.4.
UniGeneiHs.428446.

Genome annotation databases

EnsembliENST00000084798; ENSP00000084798; ENSG00000063180.
GeneIDi770.
KEGGihsa:770.
UCSCiuc002pjz.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF067662 mRNA. Translation: AAC99689.1.
AB018195 mRNA. Translation: BAA36840.1.
AY358967 mRNA. Translation: AAQ89326.1.
CR541772 mRNA. Translation: CAG46571.1.
BT007265 mRNA. Translation: AAP35929.1.
BC002662 mRNA. Translation: AAH02662.1.
AF050106 mRNA. Translation: AAD08802.1.
CCDSiCCDS12729.1.
PIRiJE0375.
RefSeqiNP_001208.2. NM_001217.4.
UniGeneiHs.428446.

3D structure databases

ProteinModelPortaliO75493.
SMRiO75493.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107224. 6 interactors.
STRINGi9606.ENSP00000084798.

Chemistry databases

ChEMBLiCHEMBL2420.
DrugBankiDB00909. Zonisamide.

PTM databases

iPTMnetiO75493.
PhosphoSitePlusiO75493.

Polymorphism and mutation databases

BioMutaiCA11.

Proteomic databases

PaxDbiO75493.
PeptideAtlasiO75493.
PRIDEiO75493.

Protocols and materials databases

DNASUi770.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000084798; ENSP00000084798; ENSG00000063180.
GeneIDi770.
KEGGihsa:770.
UCSCiuc002pjz.2. human.

Organism-specific databases

CTDi770.
DisGeNETi770.
GeneCardsiCA11.
HGNCiHGNC:1370. CA11.
HPAiHPA041778.
MIMi604644. gene.
neXtProtiNX_O75493.
OpenTargetsiENSG00000063180.
PharmGKBiPA25986.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0382. Eukaryota.
COG3338. LUCA.
GeneTreeiENSGT00740000115510.
HOGENOMiHOG000019899.
HOVERGENiHBG097666.
InParanoidiO75493.
OMAiEHQINHE.
OrthoDBiEOG091G0T4J.
PhylomeDBiO75493.
TreeFamiTF352926.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000063180-MONOMER.

Miscellaneous databases

ChiTaRSiCA11. human.
GeneWikiiCA11.
GenomeRNAii770.
PROiO75493.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000063180.
CleanExiHS_CA11.
ExpressionAtlasiO75493. baseline and differential.
GenevisibleiO75493. HS.

Family and domain databases

Gene3Di3.10.200.10. 1 hit.
InterProiIPR001148. Carbonic_anhydrase_a.
IPR023561. Carbonic_anhydrase_a-class.
[Graphical view]
PANTHERiPTHR18952. PTHR18952. 1 hit.
PfamiPF00194. Carb_anhydrase. 1 hit.
[Graphical view]
SMARTiSM01057. Carb_anhydrase. 1 hit.
[Graphical view]
SUPFAMiSSF51069. SSF51069. 1 hit.
PROSITEiPS51144. ALPHA_CA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAH11_HUMAN
AccessioniPrimary (citable) accession number: O75493
Secondary accession number(s): O60596, Q6FHI1, Q9UEC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: December 1, 2000
Last modified: November 2, 2016
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.