O75493 (CAH11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Carbonic anhydrase-related protein 11

Alternative name(s):
CA-RP XI
Short name=CA-XI
Short name=CARP XI
Carbonic anhydrase-related protein 2
Short name=CA-RP II
Short name=CARP-2

Gene names

Name:	CA11
Synonyms:	CARP2
ORF Names:	UNQ211/PRO237

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	328 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Does not have a catalytic activity.
Subcellular location	Secreted Potential.
Tissue specificity	Expressed abundantly in the brain with moderate expression also present in spinal cord and thyroid.
Sequence similarities	Belongs to the alpha-carbonic anhydrase family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 328	305	Carbonic anhydrase-related protein 11		PRO_0000004245
Amino acid modifications
	Glycosylation	118	1	N-linked (GlcNAc...) Ref.8
	Glycosylation	170	1	N-linked (GlcNAc...) Potential
	Glycosylation	260	1	N-linked (GlcNAc...) Potential
Experimental info
	Sequence conflict	23 – 24	2	AH → GN in BAA36840. Ref.2
	Sequence conflict	75	1	L → V in AAC99689. Ref.1
	Sequence conflict	280	1	I → M in AAD08802. Ref.7

Sequences

	Sequence		Length	Mass (Da)
	O75493 [UniParc]. Last modified December 1, 2000. Version 2. Checksum: A4FC408718B2E857	FASTA	328	36,238
	10 20 30 40 50 60 MGAAARLSAP RALVLWAALG AAAHIGPAPD PEDWWSYKDN LQGNFVPGPP FWGLVNAAWS 70 80 90 100 110 120 LCAVGKRQSP VDVELKRVLY DPFLPPLRLS TGGEKLRGTL YNTGRHVSFL PAPRPVVNVS 130 140 150 160 170 180 GGPLLYSHRL SELRLLFGAR DGAGSEHQIN HQGFSAEVQL IHFNQELYGN FSAASRGPNG 190 200 210 220 230 240 LAILSLFVNV ASTSNPFLSR LLNRDTITRI SYKNDAYFLQ DLSLELLFPE SFGFITYQGS 250 260 270 280 290 300 LSTPPCSETV TWILIDRALN ITSLQMHSLR LLSQNPPSQI FQSLSGNSRP LQPLAHRALR 310 320 GNRDPRHPER RCRGPNYRLH VDGVPHGR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and tissue expression of a novel human carbonic anhydrase-related protein, CARP-2, mapping to chromosome 19q13.3." Bellingham J., Gregory-Evans K., Gregory-Evans C.Y. Biochem. Biophys. Res. Commun. 253:364-367(1998) [PubMed: 9878543] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"cDNA sequence, mRNA expression, and chromosomal localization of human carbonic anhydrase-related protein, CA-RP XI." Fujikawa-Adachi K., Nishimori I., Taguchi T., Yuri K., Onishi S. Biochim. Biophys. Acta 1431:518-524(1999) [PubMed: 10350627] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Pancreas.
[3]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Uterus.
[7]	"Evolutionarily conserved, 'acatalytic' carbonic anhydrase-related protein XI contains a sequence motif present in the neuropeptide sauvagine: the human CA-RP XI gene (CA11) is embedded between the secretor gene cluster and the DBP gene at 19q13.3." Lovejoy D.A., Hewett-Emmett D., Porter C.A., Cepoi D., Sheffield A., Vale W.W., Tashian R.E. Genomics 54:484-493(1998) [PubMed: 9878252] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 48-314. Tissue: Brain.
[8]	"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry." Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D. J. Proteome Res. 4:2070-2080(2005) [PubMed: 16335952] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-118, MASS SPECTROMETRY. Tissue: Plasma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF067662 mRNA. Translation: AAC99689.1. AB018195 mRNA. Translation: BAA36840.1. AY358967 mRNA. Translation: AAQ89326.1. CR541772 mRNA. Translation: CAG46571.1. BT007265 mRNA. Translation: AAP35929.1. BC002662 mRNA. Translation: AAH02662.1. AF050106 mRNA. Translation: AAD08802.1.
IPI	IPI00025812.
PIR	JE0375.
RefSeq	NP_001208.2. NM_001217.3.
UniGene	Hs.428446.
3D structure databases
ProteinModelPortal	O75493.
SMR	O75493. Positions 34-304.
ModBase	Search...
Protein-protein interaction databases
STRING	O75493.
Proteomic databases
PRIDE	O75493.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000084798; ENSP00000084798; ENSG00000063180.
GeneID	770.
KEGG	hsa:770.
UCSC	uc002pjz.1. human.
Organism-specific databases
CTD	770.
GeneCards	GC19M049141.
H-InvDB	HIX0015299.
HGNC	HGNC:1370. CA11.
HPA	HPA041778.
MIM	604644. gene.
neXtProt	NX_O75493.
PharmGKB	PA25986.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG06526.
GeneTree	ENSGT00570000078862.
HOGENOM	HBG717384.
HOVERGEN	HBG097666.
InParanoid	O75493.
OMA	EHQINHE.
OrthoDB	EOG43R3MZ.
PhylomeDB	O75493.
Gene expression databases
ArrayExpress	O75493.
Bgee	O75493.
CleanEx	HS_CA11.
Genevestigator	O75493.
GermOnline	ENSG00000063180. Homo sapiens.
Family and domain databases
InterPro	IPR001148. a_carbonic_anhydrase. IPR018348. Carbonic_anhydrase-RP_CA11_mml. IPR023561. Carbonic_anhydrase_a-class. [Graphical view]
Gene3D	G3DSA:3.10.200.10. Euk_COanhd. 1 hit.
PANTHER	PTHR18952:SF10. Carbonic_anhydrase-RP_CA11_mml. 1 hit. PTHR18952. Euk_COanhd. 1 hit.
Pfam	PF00194. Carb_anhydrase. 1 hit. [Graphical view]
SMART	SM01057. Carb_anhydrase. 1 hit. [Graphical view]
SUPFAM	SSF51069. Euk_COanhd. 1 hit.
PROSITE	PS00162. ALPHA_CA_1. False negative. PS51144. ALPHA_CA_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	3110.
SOURCE	Search...

Entry information

Entry name

CAH11_HUMAN

Accession

Primary (citable) accession number: O75493
Secondary accession number(s): O60596, Q6FHI1, Q9UEC4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	December 1, 2000
Last modified:	January 25, 2012
This is version 98 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.