Reviewed,
UniProtKB/Swiss-Prot O75487 (GPC4_HUMAN)
Last modified
July 13, 2010.
Version 92.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and originHide
| Protein names | Recommended name: Glypican-4 Alternative name(s): K-glypican Cleaved into the following chain:
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| Gene names |
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| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributesHide
| Sequence length | 556 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)Hide
| Function | Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney tubules and of the central nervous system By similarity. |
| Subcellular location | Cell membrane; Lipid-anchor › GPI-anchor; Extracellular side By similarity. Secreted glypican-4: Secreted › extracellular space By similarity. |
| Sequence similarities | Belongs to the glypican family. |
OntologiesHide
| Keywords | |
|---|---|
| Cellular component | Cell membrane Membrane Secreted |
| Coding sequence diversity | Polymorphism |
| Domain | Signal |
| PTM | GPI-anchor Glycoprotein Heparan sulfate Lipoprotein Proteoglycan |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | anatomical structure morphogenesis Traceable author statement. Source: ProtInc cell proliferationTraceable author statement. Source: ProtInc |
| Cellular component | anchored to membrane Inferred from electronic annotation. Source: UniProtKB-KW extracellular spaceInferred from electronic annotation. Source: UniProtKB-SubCell integral to plasma membraneTraceable author statement. Source: ProtInc proteinaceous extracellular matrixInferred from electronic annotation. Source: InterPro |
| Molecular function | heparan sulfate proteoglycan binding Inferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)Hide
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 18 | 18 | Potential | ||||||
| Chain | 19 – 529 | 511 | Glypican-4 | PRO_0000012315 | |||||
| Chain | 19 – ? | Secreted glypican-4 | PRO_0000333847 | ||||||
| Propeptide | 530 – 556 | 27 | Removed in mature form Potential | PRO_0000012316 | |||||
Amino acid modifications | |||||||||
| Lipidation | 529 | 1 | GPI-anchor amidated serine Potential | ||||||
| Glycosylation | 494 | 1 | O-linked (Xyl...) (glycosaminoglycan) Potential | ||||||
| Glycosylation | 498 | 1 | O-linked (Xyl...) (glycosaminoglycan) Potential | ||||||
| Glycosylation | 500 | 1 | O-linked (Xyl...) (glycosaminoglycan) Potential | ||||||
| Glycosylation | 514 | 1 | N-linked (GlcNAc...) Potential | ||||||
Natural variations | |||||||||
| Natural variant | 391 | 1 | E → D. [dbSNP:rs1129980] Ref.1 Ref.2 Ref.3 Ref.9 | VAR_016191 | |||||
| Natural variant | 442 | 1 | A → V. [dbSNP:rs1048369] Ref.1 Ref.3 Ref.9 | VAR_016192 | |||||
SequencesHide
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ReferencesHide
| « Hide 'large scale' references | |
| [1] | "GPC4, the gene for human K-glypican, flanks GPC3 on Xq26: deletion of the GPC3-GPC4 gene cluster in one family with Simpson-Golabi-Behmel syndrome." Veugelers M., Vermeesch J., Watanabe K., Yamaguchi Y., Marynen P., David G. Genomics 53:1-11(1998) [PubMed: 9787072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ASP-391 AND VAL-442. Tissue: Brain. |
| [2] | Pilia G., Mazzarella R., Huber R., Crisponi L., Lindsay S., Ireland M., Cao A., Schlessinger D. Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASP-391. |
| [3] | Zhang B., Feng Z., Zhou Y., Peng X., Yuan J., Qiang B. Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ASP-391 AND VAL-442. |
| [4] | "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. Gray A.M.Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [5] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. |
| [6] | "The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. Bentley D.R.Nature 434:325-337(2005) [PubMed: 15772651] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [7] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [8] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin. |
| [9] | "Mutational analysis of the GPC3/GPC4 glypican gene cluster on Xq26 in patients with Simpson-Golabi-Behmel syndrome: identification of loss-of-function mutations in the GPC3 gene." Veugelers M., Cat B.D., Muyldermans S.Y., Reekmans G., Delande N., Frints S., Legius E., Fryns J.-P., Schrander-Stumpel C., Weidle B., Magdalena N., David G. Hum. Mol. Genet. 9:1321-1328(2000) [PubMed: 10814714] [Abstract] Cited for: VARIANTS ASP-391 AND VAL-442. |
Cross-referencesHide
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF030186 mRNA. Translation: AAC69991.1. AF064826 mRNA. Translation: AAC31899.1. AL034400, AL109623 Genomic DNA. Translation: CAI42076.1. AL109623, AL034400 Genomic DNA. Translation: CAB86664.2. AY358507 mRNA. Translation: AAQ88871.1. AY052833 mRNA. Translation: AAL11018.1. AK312605 mRNA. Translation: BAG35494.1. CH471107 Genomic DNA. Translation: EAX11772.1. BC017166 mRNA. Translation: AAH17166.1. |
| IPI | IPI00232571. |
| RefSeq | NP_001439.2. |
| UniGene | Hs.58367 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | O75487. |
Proteomic databases | |
| PeptideAtlas | O75487. |
| PRIDE | O75487. |
Genome annotation databases | |
| Ensembl | ENST00000370828; ENSP00000359864; ENSG00000076716; Homo sapiens. [Genome view] |
| GeneID | 2239. |
| KEGG | hsa:2239. |
| UCSC | uc004exc.1. human. |
Organism-specific databases | |
| CTD | 2239. |
| GeneCards | GC0XM132261. |
| H-InvDB | HIX0028335. |
| HGNC | HGNC:4452. GPC4. |
| HPA | HPA030836. |
| MIM | 300168. gene. |
| Orphanet | 373. Simpson-Golabi-Behmel syndrome. |
| PharmGKB | PA28833. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG13317. |
| HOGENOM | HBG713994. |
| HOVERGEN | HBG003464. |
| InParanoid | O75487. |
| OMA | MKNAYNG. |
| OrthoDB | EOG9Z656W. |
| PhylomeDB | O75487. |
Gene expression databases | |
| ArrayExpress | O75487. |
| Bgee | O75487. |
| CleanEx | HS_GPC4. |
| Genevestigator | O75487. |
| GermOnline | ENSG00000076716. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR001863. Glypican. IPR019803. Glypican_CS. [Graphical view] |
| PANTHER | PTHR10822. Glypican. 1 hit. |
| Pfam | PF01153. Glypican. 1 hit. [Graphical view] |
| PROSITE | PS01207. GLYPICAN. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 9061. |
| SOURCE | Search... |
Entry informationHide
| Entry name | GPC4_HUMAN | ||||||||
| Accession | Primary (citable) accession number: O75487 Secondary accession number(s): B2R6J7 Q9UPD9 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documentsHide
| Human chromosome X Human chromosome X: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


