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O75487

- GPC4_HUMAN

UniProt

O75487 - GPC4_HUMAN

Protein

Glypican-4

Gene

GPC4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 4 (16 May 2003)
      Previous versions | rss
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    Functioni

    Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney tubules and of the central nervous system By similarity.By similarity

    GO - Biological processi

    1. anatomical structure morphogenesis Source: ProtInc
    2. carbohydrate metabolic process Source: Reactome
    3. cell proliferation Source: ProtInc
    4. chondroitin sulfate metabolic process Source: Reactome
    5. glycosaminoglycan biosynthetic process Source: Reactome
    6. glycosaminoglycan catabolic process Source: Reactome
    7. glycosaminoglycan metabolic process Source: Reactome
    8. phototransduction, visible light Source: Reactome
    9. retinoid metabolic process Source: Reactome
    10. small molecule metabolic process Source: Reactome

    Enzyme and pathway databases

    ReactomeiREACT_120752. HS-GAG degradation.
    REACT_121248. HS-GAG biosynthesis.
    REACT_121408. A tetrasaccharide linker sequence is required for GAG synthesis.
    REACT_24968. Retinoid metabolism and transport.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glypican-4
    Alternative name(s):
    K-glypican
    Cleaved into the following chain:
    Gene namesi
    Name:GPC4
    ORF Names:UNQ474/PRO937
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:4452. GPC4.

    Subcellular locationi

    Cell membrane By similarity; Lipid-anchorGPI-anchor By similarity; Extracellular side By similarity

    GO - Cellular componenti

    1. anchored component of membrane Source: UniProtKB-KW
    2. external side of plasma membrane Source: MGI
    3. extracellular space Source: UniProtKB-SubCell
    4. extracellular vesicular exosome Source: UniProt
    5. Golgi lumen Source: Reactome
    6. integral component of plasma membrane Source: ProtInc
    7. lysosomal lumen Source: Reactome
    8. nucleus Source: UniProt
    9. plasma membrane Source: Reactome
    10. proteinaceous extracellular matrix Source: InterPro

    Keywords - Cellular componenti

    Cell membrane, Membrane, Secreted

    Pathology & Biotechi

    Organism-specific databases

    Orphaneti373. Simpson-Golabi-Behmel syndrome.
    PharmGKBiPA28833.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 529511Glypican-4PRO_0000012315Add
    BLAST
    Chaini19 – ?Secreted glypican-4PRO_0000333847
    Propeptidei530 – 55627Removed in mature formSequence AnalysisPRO_0000012316Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei357 – 3571Phosphoserine1 Publication
    Glycosylationi494 – 4941O-linked (Xyl...) (glycosaminoglycan)Sequence Analysis
    Glycosylationi498 – 4981O-linked (Xyl...) (glycosaminoglycan)Sequence Analysis
    Glycosylationi500 – 5001O-linked (Xyl...) (glycosaminoglycan)Sequence Analysis
    Glycosylationi514 – 5141N-linked (GlcNAc...)Sequence Analysis
    Lipidationi529 – 5291GPI-anchor amidated serineSequence Analysis

    Keywords - PTMi

    Glycoprotein, GPI-anchor, Heparan sulfate, Lipoprotein, Phosphoprotein, Proteoglycan

    Proteomic databases

    MaxQBiO75487.
    PaxDbiO75487.
    PeptideAtlasiO75487.
    PRIDEiO75487.

    PTM databases

    PhosphoSiteiO75487.

    Expressioni

    Gene expression databases

    ArrayExpressiO75487.
    BgeeiO75487.
    CleanExiHS_GPC4.
    GenevestigatoriO75487.

    Organism-specific databases

    HPAiHPA030836.

    Interactioni

    Protein-protein interaction databases

    BioGridi108530. 6 interactions.
    IntActiO75487. 7 interactions.
    STRINGi9606.ENSP00000359864.

    Structurei

    3D structure databases

    ProteinModelPortaliO75487.
    SMRiO75487. Positions 26-484.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glypican family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG235988.
    HOVERGENiHBG003464.
    InParanoidiO75487.
    KOiK08110.
    OMAiQCPSEFE.
    OrthoDBiEOG761BTG.
    PhylomeDBiO75487.
    TreeFamiTF105317.

    Family and domain databases

    InterProiIPR001863. Glypican.
    IPR019803. Glypican_CS.
    [Graphical view]
    PANTHERiPTHR10822. PTHR10822. 1 hit.
    PfamiPF01153. Glypican. 1 hit.
    [Graphical view]
    PROSITEiPS01207. GLYPICAN. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O75487-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MARFGLPALL CTLAVLSAAL LAAELKSKSC SEVRRLYVSK GFNKNDAPLH    50
    EINGDHLKIC PQGSTCCSQE MEEKYSLQSK DDFKSVVSEQ CNHLQAVFAS 100
    RYKKFDEFFK ELLENAEKSL NDMFVKTYGH LYMQNSELFK DLFVELKRYY 150
    VVGNVNLEEM LNDFWARLLE RMFRLVNSQY HFTDEYLECV SKYTEQLKPF 200
    GDVPRKLKLQ VTRAFVAART FAQGLAVAGD VVSKVSVVNP TAQCTHALLK 250
    MIYCSHCRGL VTVKPCYNYC SNIMRGCLAN QGDLDFEWNN FIDAMLMVAE 300
    RLEGPFNIES VMDPIDVKIS DAIMNMQDNS VQVSQKVFQG CGPPKPLPAG 350
    RISRSISESA FSARFRPHHP EERPTTAAGT SLDRLVTDVK EKLKQAKKFW 400
    SSLPSNVCND ERMAAGNGNE DDCWNGKGKS RYLFAVTGNG LANQGNNPEV 450
    QVDTSKPDIL ILRQIMALRV MTSKMKNAYN GNDVDFFDIS DESSGEGSGS 500
    GCEYQQCPSE FDYNATDHAG KSANEKADSA GVRPGAQAYL LTVFCILFLV 550
    MQREWR 556
    Length:556
    Mass (Da):62,412
    Last modified:May 16, 2003 - v4
    Checksum:i827E07FAA0BD8188
    GO
    Isoform 2 (identifier: O75487-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-70: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:486
    Mass (Da):54,910
    Checksum:iB83D796B5B026A96
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti391 – 3911E → D.4 Publications
    Corresponds to variant rs1129980 [ dbSNP | Ensembl ].
    VAR_016191
    Natural varianti442 – 4421A → V.3 Publications
    Corresponds to variant rs1048369 [ dbSNP | Ensembl ].
    VAR_016192

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 7070Missing in isoform 2. 1 PublicationVSP_056570Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF030186 mRNA. Translation: AAC69991.1.
    AF064826 mRNA. Translation: AAC31899.1.
    AY358507 mRNA. Translation: AAQ88871.1.
    AY052833 mRNA. Translation: AAL11018.1.
    AK304207 mRNA. Translation: BAG65082.1.
    AK312605 mRNA. Translation: BAG35494.1.
    AL034400, AL109623 Genomic DNA. Translation: CAI42076.1.
    AL109623, AL034400 Genomic DNA. Translation: CAB86664.2.
    CH471107 Genomic DNA. Translation: EAX11772.1.
    BC017166 mRNA. Translation: AAH17166.1.
    CCDSiCCDS14637.1.
    RefSeqiNP_001439.2. NM_001448.2.
    UniGeneiHs.58367.

    Genome annotation databases

    EnsembliENST00000370828; ENSP00000359864; ENSG00000076716.
    ENST00000535467; ENSP00000444959; ENSG00000076716.
    GeneIDi2239.
    KEGGihsa:2239.
    UCSCiuc004exc.1. human.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF030186 mRNA. Translation: AAC69991.1 .
    AF064826 mRNA. Translation: AAC31899.1 .
    AY358507 mRNA. Translation: AAQ88871.1 .
    AY052833 mRNA. Translation: AAL11018.1 .
    AK304207 mRNA. Translation: BAG65082.1 .
    AK312605 mRNA. Translation: BAG35494.1 .
    AL034400 , AL109623 Genomic DNA. Translation: CAI42076.1 .
    AL109623 , AL034400 Genomic DNA. Translation: CAB86664.2 .
    CH471107 Genomic DNA. Translation: EAX11772.1 .
    BC017166 mRNA. Translation: AAH17166.1 .
    CCDSi CCDS14637.1.
    RefSeqi NP_001439.2. NM_001448.2.
    UniGenei Hs.58367.

    3D structure databases

    ProteinModelPortali O75487.
    SMRi O75487. Positions 26-484.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108530. 6 interactions.
    IntActi O75487. 7 interactions.
    STRINGi 9606.ENSP00000359864.

    PTM databases

    PhosphoSitei O75487.

    Proteomic databases

    MaxQBi O75487.
    PaxDbi O75487.
    PeptideAtlasi O75487.
    PRIDEi O75487.

    Protocols and materials databases

    DNASUi 2239.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000370828 ; ENSP00000359864 ; ENSG00000076716 .
    ENST00000535467 ; ENSP00000444959 ; ENSG00000076716 .
    GeneIDi 2239.
    KEGGi hsa:2239.
    UCSCi uc004exc.1. human.

    Organism-specific databases

    CTDi 2239.
    GeneCardsi GC0XM132434.
    GeneReviewsi GPC4.
    HGNCi HGNC:4452. GPC4.
    HPAi HPA030836.
    MIMi 300168. gene.
    neXtProti NX_O75487.
    Orphaneti 373. Simpson-Golabi-Behmel syndrome.
    PharmGKBi PA28833.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG235988.
    HOVERGENi HBG003464.
    InParanoidi O75487.
    KOi K08110.
    OMAi QCPSEFE.
    OrthoDBi EOG761BTG.
    PhylomeDBi O75487.
    TreeFami TF105317.

    Enzyme and pathway databases

    Reactomei REACT_120752. HS-GAG degradation.
    REACT_121248. HS-GAG biosynthesis.
    REACT_121408. A tetrasaccharide linker sequence is required for GAG synthesis.
    REACT_24968. Retinoid metabolism and transport.

    Miscellaneous databases

    ChiTaRSi GPC4. human.
    GeneWikii Glypican_4.
    GenomeRNAii 2239.
    NextBioi 9061.
    PROi O75487.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O75487.
    Bgeei O75487.
    CleanExi HS_GPC4.
    Genevestigatori O75487.

    Family and domain databases

    InterProi IPR001863. Glypican.
    IPR019803. Glypican_CS.
    [Graphical view ]
    PANTHERi PTHR10822. PTHR10822. 1 hit.
    Pfami PF01153. Glypican. 1 hit.
    [Graphical view ]
    PROSITEi PS01207. GLYPICAN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "GPC4, the gene for human K-glypican, flanks GPC3 on Xq26: deletion of the GPC3-GPC4 gene cluster in one family with Simpson-Golabi-Behmel syndrome."
      Veugelers M., Vermeesch J., Watanabe K., Yamaguchi Y., Marynen P., David G.
      Genomics 53:1-11(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS ASP-391 AND VAL-442.
      Tissue: Brain.
    2. Pilia G., Mazzarella R., Huber R., Crisponi L., Lindsay S., Ireland M., Cao A., Schlessinger D.
      Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ASP-391.
    3. Zhang B., Feng Z., Zhou Y., Peng X., Yuan J., Qiang B.
      Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS ASP-391 AND VAL-442.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain and Trachea.
    6. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Skin.
    9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-357, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Mutational analysis of the GPC3/GPC4 glypican gene cluster on Xq26 in patients with Simpson-Golabi-Behmel syndrome: identification of loss-of-function mutations in the GPC3 gene."
      Veugelers M., Cat B.D., Muyldermans S.Y., Reekmans G., Delande N., Frints S., Legius E., Fryns J.-P., Schrander-Stumpel C., Weidle B., Magdalena N., David G.
      Hum. Mol. Genet. 9:1321-1328(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS ASP-391 AND VAL-442.

    Entry informationi

    Entry nameiGPC4_HUMAN
    AccessioniPrimary (citable) accession number: O75487
    Secondary accession number(s): B2R6J7
    , B4E2C0, Q6ZMA6, Q96L43, Q9NU08, Q9UJN1, Q9UPD9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 16, 2003
    Last modified: October 1, 2014
    This is version 129 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3