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Protein

PC4 and SFRS1-interacting protein

Gene

PSIP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration.1 Publication

GO - Molecular functioni

  • activating transcription factor binding Source: UniProtKB
  • chromatin binding Source: UniProtKB
  • poly(A) RNA binding Source: UniProtKB
  • RNA polymerase II transcription coactivator activity Source: UniProtKB
  • supercoiled DNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-162592. Integration of provirus.
R-HSA-164843. 2-LTR circle formation.
R-HSA-175567. Integration of viral DNA into host genomic DNA.
R-HSA-177539. Autointegration results in viral DNA circles.
R-HSA-180689. APOBEC3G mediated resistance to HIV-1 infection.
R-HSA-180910. Vpr-mediated nuclear import of PICs.
SIGNORiO75475.

Names & Taxonomyi

Protein namesi
Recommended name:
PC4 and SFRS1-interacting protein
Alternative name(s):
CLL-associated antigen KW-7
Dense fine speckles 70 kDa protein
Short name:
DFS 70
Lens epithelium-derived growth factor
Transcriptional coactivator p75/p52
Gene namesi
Name:PSIP1
Synonyms:DFS70, LEDGF, PSIP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:9527. PSIP1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • nuclear heterochromatin Source: UniProtKB
  • nuclear periphery Source: UniProtKB
  • nucleoplasm Source: UniProtKB
  • nucleus Source: UniProtKB
  • transcriptionally active chromatin Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving PSIP1 is associated with pediatric acute myeloid leukemia (AML) with intermediate characteristics between M2-M3 French-American-British (FAB) subtypes. Translocation t(9;11)(p22;p15) with NUP98. The chimeric transcript is an in-frame fusion of NUP98 exon 8 to PSIP1 exon 4.

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi360K → A: Reduced interaction with POGZ, CDCA7L and human HIV-1 integrase. 1 Publication1
Mutagenesisi365I → A: Loss of interaction with human HIV-1 integrase; reduced interaction with POGZ and CDCA7L. 2 Publications1
Mutagenesisi366D → A or N: Loss of interaction with human HIV-1 integrase; no effect on interaction with CDCA7L. 2 Publications1
Mutagenesisi366D → A: No effect on interaction with POGZ. 2 Publications1
Mutagenesisi370V → A: Reduced interaction with POGZ, CDCA7L and human HIV-1 integrase. 1 Publication1
Mutagenesisi406F → A: Loss of interaction with human HIV-1 integrase and POGZ; reduced interaction with CDCA7L. 2 Publications1
Mutagenesisi408V → A: Reduced interaction with human HIV-1 integrase; no effect on interaction with POGZ and CDCA7L. 2 Publications1

Organism-specific databases

DisGeNETi11168.
OpenTargetsiENSG00000164985.
PharmGKBiPA33872.

Protein family/group databases

Allergomei2120. Hom s DSF70.

Polymorphism and mutation databases

BioMutaiPSIP1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001917081 – 530PC4 and SFRS1-interacting proteinAdd BLAST530

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei102PhosphoserineBy similarity1
Modified residuei105PhosphoserineBy similarity1
Modified residuei106PhosphoserineCombined sources1
Modified residuei115PhosphothreonineBy similarity1
Modified residuei122PhosphothreonineCombined sources1
Modified residuei129PhosphoserineCombined sources1
Modified residuei141PhosphothreonineCombined sources1
Modified residuei167PhosphothreonineCombined sources1
Modified residuei177PhosphoserineCombined sources1
Modified residuei206PhosphoserineCombined sources1
Modified residuei271PhosphoserineCombined sources1
Modified residuei272PhosphothreonineCombined sources1
Modified residuei273PhosphoserineCombined sources1
Modified residuei275PhosphoserineCombined sources1
Modified residuei434PhosphoserineCombined sources1
Modified residuei437PhosphothreonineCombined sources1
Modified residuei443PhosphoserineCombined sources1
Modified residuei514PhosphoserineCombined sources1
Modified residuei517CitrullineBy similarity1
Modified residuei522PhosphoserineCombined sources1
Modified residuei527PhosphothreonineCombined sources1

Post-translational modificationi

Citrullinated by PADI4.By similarity

Keywords - PTMi

Citrullination, Phosphoprotein

Proteomic databases

EPDiO75475.
MaxQBiO75475.
PaxDbiO75475.
PeptideAtlasiO75475.
PRIDEiO75475.
TopDownProteomicsiO75475-1. [O75475-1]
O75475-2. [O75475-2]

PTM databases

iPTMnetiO75475.
PhosphoSitePlusiO75475.
SwissPalmiO75475.

Miscellaneous databases

PMAP-CutDBO75475.

Expressioni

Tissue specificityi

Widely expressed. Expressed at high level in the thymus. Expressed in fetal and adult brain. Expressed in neurons, but not astrocytes. Markedly elevated in fetal as compared to adult brain. In the adult brain, expressed in the subventricular zone (SVZ), in hippocampus, and undetectable elsewhere. In the fetal brain, expressed in the germinal neuroepithelium and cortical plate regions.2 Publications

Gene expression databases

BgeeiENSG00000164985.
CleanExiHS_PSIP1.
ExpressionAtlasiO75475. baseline and differential.
GenevisibleiO75475. HS.

Organism-specific databases

HPAiCAB013718.
HPA019697.

Interactioni

Subunit structurei

Monomer. Interacts with IFRD1/PC4. Isoform 2 interacts with SFRS1. Isoform 1 interacts POGZ and CDCA7L. Isoform 1 interacts with lentiviral integrase and acts as a chromatin tethering factor to the chromosomal DNA. Isoform 1 interacts in particular with the human HIV-1 integrase protein (HIV-1 IN), determining its nuclear localization, its tight association with chromatin and its protection from the proteasome. Isoform 1 interacts also with HIV-2 IN. Isoform 2 does not interact with HIV-1 IN.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
gag-polP0458521EBI-1801773,EBI-3989067From a different organism.
gag-polP124973EBI-5279836,EBI-10131955From a different organism.
SUMO1P631654EBI-1801773,EBI-80140

GO - Molecular functioni

  • activating transcription factor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi116339. 51 interactors.
DIPiDIP-46656N.
IntActiO75475. 22 interactors.
MINTiMINT-4527154.
STRINGi9606.ENSP00000370109.

Chemistry databases

BindingDBiO75475.

Structurei

Secondary structure

1530
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 4Combined sources3
Beta strandi10 – 13Combined sources4
Beta strandi21 – 25Combined sources5
Beta strandi30 – 33Combined sources4
Beta strandi40 – 44Combined sources5
Turni45 – 47Combined sources3
Beta strandi50 – 53Combined sources4
Helixi55 – 57Combined sources3
Beta strandi58 – 60Combined sources3
Helixi61 – 68Combined sources8
Helixi77 – 86Combined sources10
Helixi347 – 362Combined sources16
Helixi365 – 367Combined sources3
Helixi370 – 381Combined sources12
Helixi387 – 391Combined sources5
Helixi394 – 403Combined sources10
Helixi410 – 425Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Z9ENMR-A347-471[»]
2B4JX-ray2.02C/D347-442[»]
2M16NMR-A1-93[»]
2MSRNMR-B344-426[»]
2MTNNMR-A337-442[»]
2N3ANMR-B348-426[»]
3F9KX-ray3.20C/G/K/O/S/W/a/e/i/m/q/u347-435[»]
3HPGX-ray3.28G/H/I/J/K/L347-435[»]
3HPHX-ray2.64E/F/G/H348-435[»]
3U88X-ray3.00C/D347-435[»]
3ZEHNMR-A3-100[»]
4FU6X-ray2.10A1-135[»]
ProteinModelPortaliO75475.
SMRiO75475.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO75475.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 64PWWPPROSITE-ProRule annotationAdd BLAST64

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili306 – 334Sequence analysisAdd BLAST29
Coiled coili371 – 395Sequence analysisAdd BLAST25

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi146 – 156Nuclear localization signal1 PublicationAdd BLAST11

Domaini

Residues 340-417 are necessary and sufficient for the interaction with HIV-1 IN (IBD domain).

Sequence similaritiesi

Belongs to the HDGF family.Curated
Contains 1 PWWP domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1904. Eukaryota.
ENOG410Y5WD. LUCA.
GeneTreeiENSGT00530000063013.
HOVERGENiHBG108300.
InParanoidiO75475.
OMAiCPSETDM.
OrthoDBiEOG091G045X.
PhylomeDBiO75475.
TreeFamiTF105385.

Family and domain databases

InterProiIPR021567. LEDGF.
IPR000313. PWWP_dom.
IPR017859. Treacle-like_TCS.
[Graphical view]
PfamiPF11467. LEDGF. 1 hit.
PF00855. PWWP. 1 hit.
[Graphical view]
PRINTSiPR01503. TREACLE.
SMARTiSM00293. PWWP. 1 hit.
[Graphical view]
PROSITEiPS50812. PWWP. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75475-1) [UniParc]FASTAAdd to basket
Also known as: p75, PSIP1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTRDFKPGDL IFAKMKGYPH WPARVDEVPD GAVKPPTNKL PIFFFGTHET
60 70 80 90 100
AFLGPKDIFP YSENKEKYGK PNKRKGFNEG LWEIDNNPKV KFSSQQAATK
110 120 130 140 150
QSNASSDVEV EEKETSVSKE DTDHEEKASN EDVTKAVDIT TPKAARRGRK
160 170 180 190 200
RKAEKQVETE EAGVVTTATA SVNLKVSPKR GRPAATEVKI PKPRGRPKMV
210 220 230 240 250
KQPCPSESDI ITEEDKSKKK GQEEKQPKKQ PKKDEEGQKE EDKPRKEPDK
260 270 280 290 300
KEGKKEVESK RKNLAKTGVT STSDSEEEGD DQEGEKKRKG GRNFQTAHRR
310 320 330 340 350
NMLKGQHEKE AADRKRKQEE QMETEQQNKD EGKKPEVKKV EKKRETSMDS
360 370 380 390 400
RLQRIHAEIK NSLKIDNLDV NRCIEALDEL ASLQVTMQQA QKHTEMITTL
410 420 430 440 450
KKIRRFKVSQ VIMEKSTMLY NKFKNMFLVG EGDSVITQVL NKSLAEQRQH
460 470 480 490 500
EEANKTKDQG KKGPNKKLEK EQTGSKTLNG GSDAQDGNQP QHNGESNEDS
510 520 530
KDNHEASTKK KPSSEERETE ISLKDSTLDN
Note: Less active than isoform 2 as transcriptional coactivator, but more abundant in cells.
Length:530
Mass (Da):60,103
Last modified:November 1, 1998 - v1
Checksum:i4B653D02B1D0E174
GO
Isoform 2 (identifier: O75475-2) [UniParc]FASTAAdd to basket
Also known as: p52, PSIP2

The sequence of this isoform differs from the canonical sequence as follows:
     326-333: QQNKDEGK → HQTTCNLQ
     334-530: Missing.

Show »
Length:333
Mass (Da):37,725
Checksum:iDAFEC8F815C06FCD
GO
Isoform 3 (identifier: O75475-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     326-530: QQNKDEGKKP...ISLKDSTLDN → HFAL

Show »
Length:329
Mass (Da):37,268
Checksum:iF35C00DDD27E9BAE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti153 – 161Missing in AAH64135 (PubMed:15489334).Curated9
Sequence conflicti224E → G in AAC97946 (PubMed:9822615).Curated1
Sequence conflicti224E → G in AAC97945 (PubMed:9822615).Curated1
Sequence conflicti272T → P in AAB52589 (PubMed:10856157).Curated1
Sequence conflicti420Y → F in AAC97946 (PubMed:9822615).Curated1
Sequence conflicti420Y → F in AAB52589 (PubMed:10856157).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_044435326 – 530QQNKD…STLDN → HFAL in isoform 3. 1 PublicationAdd BLAST205
Alternative sequenceiVSP_014297326 – 333QQNKDEGK → HQTTCNLQ in isoform 2. 2 Publications8
Alternative sequenceiVSP_014298334 – 530Missing in isoform 2. 2 PublicationsAdd BLAST197

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098483 mRNA. Translation: AAC97946.1.
AF098482 mRNA. Translation: AAC97945.1.
AF063020 mRNA. Translation: AAC25167.1.
AF199339 Genomic DNA. Translation: AAF25870.1.
AF199339 Genomic DNA. Translation: AAF25871.1.
AF432220 mRNA. Translation: AAL99926.1.
AL359998, AL441925, AL513423 Genomic DNA. Translation: CAH71355.1.
AL441925, AL359998, AL513423 Genomic DNA. Translation: CAI13287.1.
CH471071 Genomic DNA. Translation: EAW58677.1.
CH471071 Genomic DNA. Translation: EAW58678.1.
CH471071 Genomic DNA. Translation: EAW58679.1.
BC044568 mRNA. Translation: AAH44568.2.
BC064135 mRNA. Translation: AAH64135.1.
U94319 mRNA. Translation: AAB52589.1.
CCDSiCCDS6479.1. [O75475-1]
CCDS6480.1. [O75475-2]
CCDS83348.1. [O75475-3]
PIRiJC7168.
RefSeqiNP_001121689.1. NM_001128217.2. [O75475-1]
NP_001304827.1. NM_001317898.1. [O75475-3]
NP_001304829.1. NM_001317900.1.
NP_066967.3. NM_021144.3. [O75475-2]
NP_150091.2. NM_033222.4. [O75475-1]
UniGeneiHs.658434.

Genome annotation databases

EnsembliENST00000380715; ENSP00000370091; ENSG00000164985. [O75475-3]
ENST00000380716; ENSP00000370092; ENSG00000164985. [O75475-2]
ENST00000380733; ENSP00000370109; ENSG00000164985. [O75475-1]
ENST00000380738; ENSP00000370114; ENSG00000164985. [O75475-1]
ENST00000397519; ENSP00000380653; ENSG00000164985. [O75475-2]
GeneIDi11168.
KEGGihsa:11168.
UCSCiuc003zlv.6. human. [O75475-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098483 mRNA. Translation: AAC97946.1.
AF098482 mRNA. Translation: AAC97945.1.
AF063020 mRNA. Translation: AAC25167.1.
AF199339 Genomic DNA. Translation: AAF25870.1.
AF199339 Genomic DNA. Translation: AAF25871.1.
AF432220 mRNA. Translation: AAL99926.1.
AL359998, AL441925, AL513423 Genomic DNA. Translation: CAH71355.1.
AL441925, AL359998, AL513423 Genomic DNA. Translation: CAI13287.1.
CH471071 Genomic DNA. Translation: EAW58677.1.
CH471071 Genomic DNA. Translation: EAW58678.1.
CH471071 Genomic DNA. Translation: EAW58679.1.
BC044568 mRNA. Translation: AAH44568.2.
BC064135 mRNA. Translation: AAH64135.1.
U94319 mRNA. Translation: AAB52589.1.
CCDSiCCDS6479.1. [O75475-1]
CCDS6480.1. [O75475-2]
CCDS83348.1. [O75475-3]
PIRiJC7168.
RefSeqiNP_001121689.1. NM_001128217.2. [O75475-1]
NP_001304827.1. NM_001317898.1. [O75475-3]
NP_001304829.1. NM_001317900.1.
NP_066967.3. NM_021144.3. [O75475-2]
NP_150091.2. NM_033222.4. [O75475-1]
UniGeneiHs.658434.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Z9ENMR-A347-471[»]
2B4JX-ray2.02C/D347-442[»]
2M16NMR-A1-93[»]
2MSRNMR-B344-426[»]
2MTNNMR-A337-442[»]
2N3ANMR-B348-426[»]
3F9KX-ray3.20C/G/K/O/S/W/a/e/i/m/q/u347-435[»]
3HPGX-ray3.28G/H/I/J/K/L347-435[»]
3HPHX-ray2.64E/F/G/H348-435[»]
3U88X-ray3.00C/D347-435[»]
3ZEHNMR-A3-100[»]
4FU6X-ray2.10A1-135[»]
ProteinModelPortaliO75475.
SMRiO75475.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116339. 51 interactors.
DIPiDIP-46656N.
IntActiO75475. 22 interactors.
MINTiMINT-4527154.
STRINGi9606.ENSP00000370109.

Chemistry databases

BindingDBiO75475.

Protein family/group databases

Allergomei2120. Hom s DSF70.

PTM databases

iPTMnetiO75475.
PhosphoSitePlusiO75475.
SwissPalmiO75475.

Polymorphism and mutation databases

BioMutaiPSIP1.

Proteomic databases

EPDiO75475.
MaxQBiO75475.
PaxDbiO75475.
PeptideAtlasiO75475.
PRIDEiO75475.
TopDownProteomicsiO75475-1. [O75475-1]
O75475-2. [O75475-2]

Protocols and materials databases

DNASUi11168.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380715; ENSP00000370091; ENSG00000164985. [O75475-3]
ENST00000380716; ENSP00000370092; ENSG00000164985. [O75475-2]
ENST00000380733; ENSP00000370109; ENSG00000164985. [O75475-1]
ENST00000380738; ENSP00000370114; ENSG00000164985. [O75475-1]
ENST00000397519; ENSP00000380653; ENSG00000164985. [O75475-2]
GeneIDi11168.
KEGGihsa:11168.
UCSCiuc003zlv.6. human. [O75475-1]

Organism-specific databases

CTDi11168.
DisGeNETi11168.
GeneCardsiPSIP1.
HGNCiHGNC:9527. PSIP1.
HPAiCAB013718.
HPA019697.
MIMi603620. gene.
neXtProtiNX_O75475.
OpenTargetsiENSG00000164985.
PharmGKBiPA33872.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1904. Eukaryota.
ENOG410Y5WD. LUCA.
GeneTreeiENSGT00530000063013.
HOVERGENiHBG108300.
InParanoidiO75475.
OMAiCPSETDM.
OrthoDBiEOG091G045X.
PhylomeDBiO75475.
TreeFamiTF105385.

Enzyme and pathway databases

ReactomeiR-HSA-162592. Integration of provirus.
R-HSA-164843. 2-LTR circle formation.
R-HSA-175567. Integration of viral DNA into host genomic DNA.
R-HSA-177539. Autointegration results in viral DNA circles.
R-HSA-180689. APOBEC3G mediated resistance to HIV-1 infection.
R-HSA-180910. Vpr-mediated nuclear import of PICs.
SIGNORiO75475.

Miscellaneous databases

ChiTaRSiPSIP1. human.
EvolutionaryTraceiO75475.
GeneWikiiPSIP1.
GenomeRNAii11168.
PMAP-CutDBO75475.
PROiO75475.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164985.
CleanExiHS_PSIP1.
ExpressionAtlasiO75475. baseline and differential.
GenevisibleiO75475. HS.

Family and domain databases

InterProiIPR021567. LEDGF.
IPR000313. PWWP_dom.
IPR017859. Treacle-like_TCS.
[Graphical view]
PfamiPF11467. LEDGF. 1 hit.
PF00855. PWWP. 1 hit.
[Graphical view]
PRINTSiPR01503. TREACLE.
SMARTiSM00293. PWWP. 1 hit.
[Graphical view]
PROSITEiPS50812. PWWP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPSIP1_HUMAN
AccessioniPrimary (citable) accession number: O75475
Secondary accession number(s): D3DRI9
, O00256, O95368, Q6P391, Q86YB9, Q9NZI3, Q9UER6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: November 1, 1998
Last modified: November 2, 2016
This is version 157 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.