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Protein

GSK-3-binding protein FRAT2

Gene

FRAT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3.

GO - Biological processi

  • beta-catenin destruction complex disassembly Source: Reactome
  • cell proliferation Source: UniProtKB
  • multicellular organism development Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

BioCyciZFISH:ENSG00000181274-MONOMER.
ReactomeiR-HSA-196299. Beta-catenin phosphorylation cascade.
R-HSA-4641262. Disassembly of the destruction complex and recruitment of AXIN to the membrane.
SIGNORiO75474.

Names & Taxonomyi

Protein namesi
Recommended name:
GSK-3-binding protein FRAT2
Alternative name(s):
Frequently rearranged in advanced T-cell lymphomas 2
Short name:
FRAT-2
Gene namesi
Name:FRAT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:16048. FRAT2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi23401.
OpenTargetsiENSG00000181274.
PharmGKBiPA28362.

Polymorphism and mutation databases

BioMutaiFRAT2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000873341 – 233GSK-3-binding protein FRAT2Add BLAST233

Proteomic databases

MaxQBiO75474.
PaxDbiO75474.
PRIDEiO75474.

PTM databases

iPTMnetiO75474.
PhosphoSitePlusiO75474.

Expressioni

Gene expression databases

BgeeiENSG00000181274.
CleanExiHS_FRAT2.
GenevisibleiO75474. HS.

Organism-specific databases

HPAiHPA049763.

Interactioni

Subunit structurei

Binds GSK-3 and prevents GSK-3-dependent phosphorylation.

Protein-protein interaction databases

BioGridi116974. 2 interactors.
IntActiO75474. 13 interactors.
STRINGi9606.ENSP00000360058.

Structurei

3D structure databases

ProteinModelPortaliO75474.
SMRiO75474.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni174 – 196Involved in GSK-3 bindingBy similarityAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi6 – 23Asp/Glu-rich (highly acidic)Add BLAST18
Compositional biasi6 – 10Poly-Glu5
Compositional biasi13 – 21Poly-Glu9

Sequence similaritiesi

Belongs to the GSK-3-binding protein family.Curated

Phylogenomic databases

eggNOGiENOG410J5HI. Eukaryota.
ENOG410ZA2I. LUCA.
GeneTreeiENSGT00390000007081.
HOGENOMiHOG000112642.
HOVERGENiHBG051660.
InParanoidiO75474.
KOiK03096.
OMAiQRRWTQA.
OrthoDBiEOG091G0PDL.
PhylomeDBiO75474.
TreeFamiTF330804.

Family and domain databases

InterProiIPR008014. GSK3-bd.
[Graphical view]
PfamiPF05350. GSK-3_bind. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O75474-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPCRREEEEE AGEEAEGEEE EDDSFLLLQQ SVTLGSSGEV DRLVAQIGET
60 70 80 90 100
LQLDAAQDSP ASPCAPPGVP LRAPGPLAAA VPADKARPPA VPLLLPPASA
110 120 130 140 150
ETVGPAPSGA LRCALGDRGR VRGRAAPYCV AEVAAGPSAL PGPCRRGWLR
160 170 180 190 200
DAVTSRRLQQ RRWTQAGARA GDDDPHRLLQ QLVLSGNLIK EAVRRLQRAV
210 220 230
AAVAATGPAS APGPGGGRSG PDRIALQPSG SLL
Length:233
Mass (Da):24,051
Last modified:March 7, 2006 - v3
Checksum:i01ACC1DEEAB4C16F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti83A → T in AAH20165 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB045118 mRNA. Translation: BAB39165.1.
AL355490 Genomic DNA. Translation: CAI40774.1.
BC020165 mRNA. Translation: AAH20165.1.
AF062739 mRNA. Translation: AAC39786.1.
CCDSiCCDS7456.1.
PIRiJC7618.
RefSeqiNP_036215.1. NM_012083.2.
UniGeneiHs.140720.

Genome annotation databases

EnsembliENST00000371019; ENSP00000360058; ENSG00000181274.
GeneIDi23401.
KEGGihsa:23401.
UCSCiuc001knd.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB045118 mRNA. Translation: BAB39165.1.
AL355490 Genomic DNA. Translation: CAI40774.1.
BC020165 mRNA. Translation: AAH20165.1.
AF062739 mRNA. Translation: AAC39786.1.
CCDSiCCDS7456.1.
PIRiJC7618.
RefSeqiNP_036215.1. NM_012083.2.
UniGeneiHs.140720.

3D structure databases

ProteinModelPortaliO75474.
SMRiO75474.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116974. 2 interactors.
IntActiO75474. 13 interactors.
STRINGi9606.ENSP00000360058.

PTM databases

iPTMnetiO75474.
PhosphoSitePlusiO75474.

Polymorphism and mutation databases

BioMutaiFRAT2.

Proteomic databases

MaxQBiO75474.
PaxDbiO75474.
PRIDEiO75474.

Protocols and materials databases

DNASUi23401.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371019; ENSP00000360058; ENSG00000181274.
GeneIDi23401.
KEGGihsa:23401.
UCSCiuc001knd.2. human.

Organism-specific databases

CTDi23401.
DisGeNETi23401.
GeneCardsiFRAT2.
H-InvDBHIX0009086.
HGNCiHGNC:16048. FRAT2.
HPAiHPA049763.
MIMi605006. gene.
neXtProtiNX_O75474.
OpenTargetsiENSG00000181274.
PharmGKBiPA28362.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J5HI. Eukaryota.
ENOG410ZA2I. LUCA.
GeneTreeiENSGT00390000007081.
HOGENOMiHOG000112642.
HOVERGENiHBG051660.
InParanoidiO75474.
KOiK03096.
OMAiQRRWTQA.
OrthoDBiEOG091G0PDL.
PhylomeDBiO75474.
TreeFamiTF330804.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000181274-MONOMER.
ReactomeiR-HSA-196299. Beta-catenin phosphorylation cascade.
R-HSA-4641262. Disassembly of the destruction complex and recruitment of AXIN to the membrane.
SIGNORiO75474.

Miscellaneous databases

GeneWikiiFRAT2.
GenomeRNAii23401.
PROiO75474.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000181274.
CleanExiHS_FRAT2.
GenevisibleiO75474. HS.

Family and domain databases

InterProiIPR008014. GSK3-bd.
[Graphical view]
PfamiPF05350. GSK-3_bind. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFRAT2_HUMAN
AccessioniPrimary (citable) accession number: O75474
Secondary accession number(s): Q5JTI0, Q8WUL9, Q9BYG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: March 7, 2006
Last modified: November 2, 2016
This is version 123 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.