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O75473

- LGR5_HUMAN

UniProt

O75473 - LGR5_HUMAN

Protein

Leucine-rich repeat-containing G-protein coupled receptor 5

Gene

LGR5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 131 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development.5 Publications

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: ProtInc
    2. protein binding Source: UniProtKB
    3. transmembrane signaling receptor activity Source: UniProtKB

    GO - Biological processi

    1. G-protein coupled receptor signaling pathway Source: ProtInc
    2. inner ear development Source: Ensembl
    3. positive regulation of canonical Wnt signaling pathway Source: UniProtKB

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_200716. regulation of FZD by ubiquitination.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine-rich repeat-containing G-protein coupled receptor 5
    Alternative name(s):
    G-protein coupled receptor 49
    G-protein coupled receptor 67
    G-protein coupled receptor HG38
    Gene namesi
    Name:LGR5
    Synonyms:GPR49, GPR67
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:4504. LGR5.

    Subcellular locationi

    Cell membrane; Multi-pass membrane protein. Golgi apparatustrans-Golgi network membrane; Multi-pass membrane protein
    Note: Rapidly and constitutively internalized to the trans-Golgi network at steady state. Internalization to the trans-Golgi network may be the result of phosphorylation at Ser-861 and Ser-864; however, the phosphorylation event has not been proven (PubMed:23439653).1 Publication

    GO - Cellular componenti

    1. integral component of plasma membrane Source: UniProtKB
    2. trans-Golgi network membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Golgi apparatus, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi146 – 1461D → F: Abolishes activation of Wnt signaling. 1 Publication
    Mutagenesisi170 – 1701D → F: Abolishes activation of Wnt signaling. 1 Publication
    Mutagenesisi190 – 1901A → D: Abolishes activation of Wnt signaling. 1 Publication
    Mutagenesisi861 – 8611S → A: Impaired internalization to the trans-Golgi network; when associated with A-864. 1 Publication
    Mutagenesisi864 – 8641S → A: Impaired internalization to the trans-Golgi network; when associated with A-861. 1 Publication

    Organism-specific databases

    PharmGKBiPA28894.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 907886Leucine-rich repeat-containing G-protein coupled receptor 5PRO_0000012794Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi34 ↔ 40
    Disulfide bondi38 ↔ 52
    Glycosylationi63 – 631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi77 – 771N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi208 – 2081N-linked (GlcNAc...)1 Publication
    Disulfide bondi348 ↔ 373
    Disulfide bondi479 ↔ 541
    Glycosylationi500 – 5001N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi637 ↔ 712PROSITE-ProRule annotation
    Glycosylationi792 – 7921N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiO75473.
    PaxDbiO75473.
    PRIDEiO75473.

    PTM databases

    PhosphoSiteiO75473.

    Expressioni

    Tissue specificityi

    Expressed in skeletal muscle, placenta, spinal cord, and various region of brain. Expressed at the base of crypts in colonic and small mucosa stem cells. In premalignant cancer expression is not restricted to the cript base. Overexpressed in cancers of the ovary, colon and liver.3 Publications

    Gene expression databases

    ArrayExpressiO75473.
    BgeeiO75473.
    CleanExiHS_LGR5.
    GenevestigatoriO75473.

    Organism-specific databases

    HPAiHPA012530.

    Interactioni

    Subunit structurei

    Identified in a complex composed of RNF43, LGR5 and RSPO1.2 Publications

    Protein-protein interaction databases

    BioGridi114119. 1 interaction.
    STRINGi9606.ENSP00000266674.

    Structurei

    Secondary structure

    1
    907
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi39 – 435
    Turni44 – 463
    Beta strandi47 – 515
    Beta strandi68 – 725
    Beta strandi94 – 963
    Turni107 – 1126
    Beta strandi118 – 1203
    Turni133 – 1364
    Beta strandi142 – 1443
    Turni155 – 1606
    Beta strandi166 – 1683
    Helixi179 – 1824
    Beta strandi190 – 1923
    Turni203 – 2086
    Beta strandi214 – 2163
    Turni227 – 2326
    Beta strandi238 – 2403
    Helixi251 – 2555
    Beta strandi261 – 2633
    Turni274 – 2796
    Beta strandi285 – 2873
    Turni298 – 3036
    Beta strandi310 – 3134
    Beta strandi331 – 3388
    Helixi347 – 3504
    Beta strandi356 – 3583
    Beta strandi378 – 3803
    Turni393 – 3964
    Beta strandi402 – 4043
    Turni415 – 4206
    Beta strandi426 – 4283
    Beta strandi446 – 4494
    Beta strandi470 – 4723
    Turni476 – 4783
    Helixi480 – 4823
    Helixi523 – 53311
    Beta strandi534 – 5363
    Beta strandi540 – 5423

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4BSRX-ray3.20A/B22-543[»]
    4BSSX-ray3.20A/B/E/F22-543[»]
    4BSTX-ray4.30A/B22-543[»]
    4BSUX-ray3.20A/B/E/F22-543[»]
    4KNGX-ray2.50A/B32-557[»]
    ProteinModelPortaliO75473.
    SMRiO75473. Positions 28-543.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 561540ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini583 – 59311CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini615 – 63824ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini660 – 68223CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini704 – 72219ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini744 – 76724CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini789 – 80214ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini824 – 90784CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei562 – 58221Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei594 – 61421Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei639 – 65921Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei683 – 70321Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei723 – 74321Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei768 – 78821Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei803 – 82321Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini25 – 6642LRRNTAdd
    BLAST
    Repeati67 – 9024LRR 1Add
    BLAST
    Repeati91 – 11222LRR 2Add
    BLAST
    Repeati115 – 13622LRR 3Add
    BLAST
    Repeati139 – 16022LRR 4Add
    BLAST
    Repeati163 – 18422LRR 5Add
    BLAST
    Repeati187 – 20822LRR 6Add
    BLAST
    Repeati211 – 23222LRR 7Add
    BLAST
    Repeati235 – 25622LRR 8Add
    BLAST
    Repeati258 – 27922LRR 9Add
    BLAST
    Repeati282 – 30322LRR 10Add
    BLAST
    Repeati306 – 32823LRR 11Add
    BLAST
    Repeati329 – 35022LRR 12Add
    BLAST
    Repeati353 – 37422LRR 13Add
    BLAST
    Repeati375 – 39622LRR 14Add
    BLAST
    Repeati399 – 42022LRR 15Add
    BLAST
    Repeati423 – 44624LRR 16Add
    BLAST

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
    Contains 16 LRR (leucine-rich) repeats.Curated
    Contains 1 LRRNT domain.Curated

    Keywords - Domaini

    Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG4886.
    HOGENOMiHOG000231829.
    HOVERGENiHBG031675.
    InParanoidiO75473.
    KOiK04308.
    OMAiLENIWDC.
    OrthoDBiEOG7DNNTF.
    PhylomeDBiO75473.
    TreeFamiTF316814.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR002131. Gphrmn_rcpt_fam.
    IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000372. LRR-contain_N.
    IPR026906. LRR_5.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    PF00560. LRR_1. 1 hit.
    PF13306. LRR_5. 1 hit.
    PF13855. LRR_8. 2 hits.
    PF01462. LRRNT. 1 hit.
    [Graphical view]
    PRINTSiPR00373. GLYCHORMONER.
    PR00237. GPCRRHODOPSN.
    SMARTiSM00369. LRR_TYP. 8 hits.
    SM00013. LRRNT. 1 hit.
    [Graphical view]
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    PS51450. LRR. 15 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O75473-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDTSRLGVLL SLPVLLQLAT GGSSPRSGVL LRGCPTHCHC EPDGRMLLRV    50
    DCSDLGLSEL PSNLSVFTSY LDLSMNNISQ LLPNPLPSLR FLEELRLAGN 100
    ALTYIPKGAF TGLYSLKVLM LQNNQLRHVP TEALQNLRSL QSLRLDANHI 150
    SYVPPSCFSG LHSLRHLWLD DNALTEIPVQ AFRSLSALQA MTLALNKIHH 200
    IPDYAFGNLS SLVVLHLHNN RIHSLGKKCF DGLHSLETLD LNYNNLDEFP 250
    TAIRTLSNLK ELGFHSNNIR SIPEKAFVGN PSLITIHFYD NPIQFVGRSA 300
    FQHLPELRTL TLNGASQITE FPDLTGTANL ESLTLTGAQI SSLPQTVCNQ 350
    LPNLQVLDLS YNLLEDLPSF SVCQKLQKID LRHNEIYEIK VDTFQQLLSL 400
    RSLNLAWNKI AIIHPNAFST LPSLIKLDLS SNLLSSFPIT GLHGLTHLKL 450
    TGNHALQSLI SSENFPELKV IEMPYAYQCC AFGVCENAYK ISNQWNKGDN 500
    SSMDDLHKKD AGMFQAQDER DLEDFLLDFE EDLKALHSVQ CSPSPGPFKP 550
    CEHLLDGWLI RIGVWTIAVL ALTCNALVTS TVFRSPLYIS PIKLLIGVIA 600
    AVNMLTGVSS AVLAGVDAFT FGSFARHGAW WENGVGCHVI GFLSIFASES 650
    SVFLLTLAAL ERGFSVKYSA KFETKAPFSS LKVIILLCAL LALTMAAVPL 700
    LGGSKYGASP LCLPLPFGEP STMGYMVALI LLNSLCFLMM TIAYTKLYCN 750
    LDKGDLENIW DCSMVKHIAL LLFTNCILNC PVAFLSFSSL INLTFISPEV 800
    IKFILLVVVP LPACLNPLLY ILFNPHFKED LVSLRKQTYV WTRSKHPSLM 850
    SINSDDVEKQ SCDSTQALVT FTSSSITYDL PPSSVPSPAY PVTESCHLSS 900
    VAFVPCL 907
    Length:907
    Mass (Da):99,998
    Last modified:November 1, 1998 - v1
    Checksum:i822D5C5E6F0D9092
    GO
    Isoform 2 (identifier: O75473-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         263-286: Missing.

    Show »
    Length:883
    Mass (Da):97,404
    Checksum:i50B293FCFCAED440
    GO
    Isoform 3 (identifier: O75473-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         143-214: Missing.

    Show »
    Length:835
    Mass (Da):92,006
    Checksum:i352096C4523C1E2F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti90 – 901R → H in AAC77911. (PubMed:9849958)Curated
    Sequence conflicti212 – 2121L → W in AAC77911. (PubMed:9849958)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti383 – 3831H → R.
    Corresponds to variant rs12303775 [ dbSNP | Ensembl ].
    VAR_049411
    Natural varianti666 – 6661V → A.1 Publication
    Corresponds to variant rs17109924 [ dbSNP | Ensembl ].
    VAR_049412

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei143 – 21472Missing in isoform 3. 1 PublicationVSP_054782Add
    BLAST
    Alternative sequencei263 – 28624Missing in isoform 2. 1 PublicationVSP_037746Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF062006 mRNA. Translation: AAC28019.1.
    AF061444 mRNA. Translation: AAC77911.1.
    FN820440 mRNA. Translation: CBL95002.2.
    AC078860 Genomic DNA. No translation available.
    AC090116 Genomic DNA. No translation available.
    BC096324 mRNA. Translation: AAH96324.1.
    BC096325 mRNA. Translation: AAH96325.1.
    BC096326 mRNA. Translation: AAH96326.1.
    BC099650 mRNA. Translation: AAH99650.1.
    CCDSiCCDS61194.1. [O75473-2]
    CCDS61195.1. [O75473-3]
    CCDS9000.1. [O75473-1]
    PIRiJE0176.
    RefSeqiNP_001264155.1. NM_001277226.1. [O75473-2]
    NP_001264156.1. NM_001277227.1. [O75473-3]
    NP_003658.1. NM_003667.3. [O75473-1]
    UniGeneiHs.658889.

    Genome annotation databases

    GeneIDi8549.
    KEGGihsa:8549.
    UCSCiuc001swl.4. human. [O75473-1]
    uc001swm.4. human. [O75473-2]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF062006 mRNA. Translation: AAC28019.1 .
    AF061444 mRNA. Translation: AAC77911.1 .
    FN820440 mRNA. Translation: CBL95002.2 .
    AC078860 Genomic DNA. No translation available.
    AC090116 Genomic DNA. No translation available.
    BC096324 mRNA. Translation: AAH96324.1 .
    BC096325 mRNA. Translation: AAH96325.1 .
    BC096326 mRNA. Translation: AAH96326.1 .
    BC099650 mRNA. Translation: AAH99650.1 .
    CCDSi CCDS61194.1. [O75473-2 ]
    CCDS61195.1. [O75473-3 ]
    CCDS9000.1. [O75473-1 ]
    PIRi JE0176.
    RefSeqi NP_001264155.1. NM_001277226.1. [O75473-2 ]
    NP_001264156.1. NM_001277227.1. [O75473-3 ]
    NP_003658.1. NM_003667.3. [O75473-1 ]
    UniGenei Hs.658889.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4BSR X-ray 3.20 A/B 22-543 [» ]
    4BSS X-ray 3.20 A/B/E/F 22-543 [» ]
    4BST X-ray 4.30 A/B 22-543 [» ]
    4BSU X-ray 3.20 A/B/E/F 22-543 [» ]
    4KNG X-ray 2.50 A/B 32-557 [» ]
    ProteinModelPortali O75473.
    SMRi O75473. Positions 28-543.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114119. 1 interaction.
    STRINGi 9606.ENSP00000266674.

    Chemistry

    GuidetoPHARMACOLOGYi 148.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei O75473.

    Proteomic databases

    MaxQBi O75473.
    PaxDbi O75473.
    PRIDEi O75473.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 8549.
    KEGGi hsa:8549.
    UCSCi uc001swl.4. human. [O75473-1 ]
    uc001swm.4. human. [O75473-2 ]

    Organism-specific databases

    CTDi 8549.
    GeneCardsi GC12P071833.
    HGNCi HGNC:4504. LGR5.
    HPAi HPA012530.
    MIMi 606667. gene.
    neXtProti NX_O75473.
    PharmGKBi PA28894.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG4886.
    HOGENOMi HOG000231829.
    HOVERGENi HBG031675.
    InParanoidi O75473.
    KOi K04308.
    OMAi LENIWDC.
    OrthoDBi EOG7DNNTF.
    PhylomeDBi O75473.
    TreeFami TF316814.

    Enzyme and pathway databases

    Reactomei REACT_200716. regulation of FZD by ubiquitination.

    Miscellaneous databases

    GeneWikii LGR5.
    GenomeRNAii 8549.
    NextBioi 32032.
    PROi O75473.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O75473.
    Bgeei O75473.
    CleanExi HS_LGR5.
    Genevestigatori O75473.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR002131. Gphrmn_rcpt_fam.
    IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000372. LRR-contain_N.
    IPR026906. LRR_5.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    PF00560. LRR_1. 1 hit.
    PF13306. LRR_5. 1 hit.
    PF13855. LRR_8. 2 hits.
    PF01462. LRRNT. 1 hit.
    [Graphical view ]
    PRINTSi PR00373. GLYCHORMONER.
    PR00237. GPCRRHODOPSN.
    SMARTi SM00369. LRR_TYP. 8 hits.
    SM00013. LRRNT. 1 hit.
    [Graphical view ]
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    PS51450. LRR. 15 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and cloning of an orphan G protein-coupled receptor of the glycoprotein hormone receptor subfamily."
      McDonald T., Wang R., Bailey W., Xie G., Chen F., Caskey C.T., Liu Q.
      Biochem. Biophys. Res. Commun. 247:266-270(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Characterization of two LGR genes homologous to gonadotropin and thyrotropin receptors with extracellular leucine-rich repeats and a G protein-coupled, seven-transmembrane region."
      Hsu S.Y., Liang S.-G., Hsueh A.J.W.
      Mol. Endocrinol. 12:1830-1845(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Placenta.
    3. "Alternatively spliced transcript of the GPR49-mRNA occur in different tumor cell lines and soft tissue sarcoma."
      Rot S., Taubert H., Bache M., Vordermark D., Kappler M.
      Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    4. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ALA-666.
    6. "Overexpression of orphan G-protein-coupled receptor, Gpr49, in human hepatocellular carcinomas with beta-catenin mutations."
      Yamamoto Y., Sakamoto M., Fujii G., Tsuiji H., Kenetaka K., Asaka M., Hirohashi S.
      Hepatology 37:528-533(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    7. "Identification of overexpression of orphan G protein-coupled receptor GPR49 in human colon and ovarian primary tumors."
      McClanahan T., Koseoglu S., Smith K., Grein J., Gustafson E., Black S., Kirschmeier P., Samatar A.A.
      Cancer Biol. Ther. 5:419-426(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    8. "Immunostaining of Lgr5, an intestinal stem cell marker, in normal and premalignant human gastrointestinal tissue."
      Becker L., Huang Q., Mashimo H.
      ScientificWorldJournal 8:1168-1176(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    9. "LGR4 and LGR5 are R-spondin receptors mediating Wnt/beta-catenin and Wnt/PCP signalling."
      Glinka A., Dolde C., Kirsch N., Huang Y.L., Kazanskaya O., Ingelfinger D., Boutros M., Cruciat C.M., Niehrs C.
      EMBO Rep. 12:1055-1061(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH RSPO1; RSPO2; RSPO3 AND RSPO4.
    10. Cited for: FUNCTION, INTERACTION WITH RSPO1; RSPO2; RSPO3 AND RSPO4.
    11. "R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling."
      Carmon K.S., Gong X., Lin Q., Thomas A., Liu Q.
      Proc. Natl. Acad. Sci. U.S.A. 108:11452-11457(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH RSPO1; RSPO2; RSPO3 AND RSPO4.
    12. Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH RSPO1.
    13. "Constitutive Internalization of the Leucine-rich G Protein-coupled Receptor-5 (LGR5) to the Trans-Golgi Network."
      Snyder J.C., Rochelle L.K., Lyerly H.K., Caron M.G., Barak L.S.
      J. Biol. Chem. 288:10286-10297(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, MUTAGENESIS OF SER-861 AND SER-864.
    14. "Structure of stem cell growth factor R-spondin 1 in complex with the ectodomain of its receptor LGR5."
      Peng W.C., de Lau W., Forneris F., Granneman J.C., Huch M., Clevers H., Gros P.
      Cell Rep. 3:1885-1892(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF 22-543 IN COMPLEX WITH RSPO1, FUNCTION, MUTAGENESIS OF ASP-146; ASP-170 AND ALA-190, DISULFIDE BONDS.
    15. "The structural basis of R-spondin recognition by LGR5 and RNF43."
      Chen P.H., Chen X., Lin Z., Fang D., He X.
      Genes Dev. 27:1345-1350(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 32-557 IN COMPLEX WITH RNF43 AND RSPO1, SUBUNIT, DISULFIDE BONDS, GLYCOSYLATION AT ASN-208.

    Entry informationi

    Entry nameiLGR5_HUMAN
    AccessioniPrimary (citable) accession number: O75473
    Secondary accession number(s): D8MCT0
    , Q4VAM0, Q4VAM2, Q9UP75
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2002
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 131 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    LGR5 is used as a marker of adult tissue stem cells in the intestine, stomach, hair follicle, and mammary epithelium.1 Publication

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3