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O75473

- LGR5_HUMAN

UniProt

O75473 - LGR5_HUMAN

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Protein

Leucine-rich repeat-containing G-protein coupled receptor 5

Gene

LGR5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development.5 Publications

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: ProtInc
  2. transmembrane signaling receptor activity Source: UniProtKB

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: ProtInc
  2. inner ear development Source: Ensembl
  3. positive regulation of canonical Wnt signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_200716. regulation of FZD by ubiquitination.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing G-protein coupled receptor 5
Alternative name(s):
G-protein coupled receptor 49
G-protein coupled receptor 67
G-protein coupled receptor HG38
Gene namesi
Name:LGR5
Synonyms:GPR49, GPR67
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:4504. LGR5.

Subcellular locationi

Cell membrane; Multi-pass membrane protein. Golgi apparatustrans-Golgi network membrane; Multi-pass membrane protein
Note: Rapidly and constitutively internalized to the trans-Golgi network at steady state. Internalization to the trans-Golgi network may be the result of phosphorylation at Ser-861 and Ser-864; however, the phosphorylation event has not been proven (PubMed:23439653).1 Publication

GO - Cellular componenti

  1. integral component of plasma membrane Source: UniProtKB
  2. trans-Golgi network membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi146 – 1461D → F: Abolishes activation of Wnt signaling. 1 Publication
Mutagenesisi170 – 1701D → F: Abolishes activation of Wnt signaling. 1 Publication
Mutagenesisi190 – 1901A → D: Abolishes activation of Wnt signaling. 1 Publication
Mutagenesisi861 – 8611S → A: Impaired internalization to the trans-Golgi network; when associated with A-864. 1 Publication
Mutagenesisi864 – 8641S → A: Impaired internalization to the trans-Golgi network; when associated with A-861. 1 Publication

Organism-specific databases

PharmGKBiPA28894.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 907886Leucine-rich repeat-containing G-protein coupled receptor 5PRO_0000012794Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi34 ↔ 40
Disulfide bondi38 ↔ 52
Glycosylationi63 – 631N-linked (GlcNAc...)Sequence Analysis
Glycosylationi77 – 771N-linked (GlcNAc...)Sequence Analysis
Glycosylationi208 – 2081N-linked (GlcNAc...)1 Publication
Disulfide bondi348 ↔ 373
Disulfide bondi479 ↔ 541
Glycosylationi500 – 5001N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi637 ↔ 712PROSITE-ProRule annotation
Glycosylationi792 – 7921N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiO75473.
PaxDbiO75473.
PRIDEiO75473.

PTM databases

PhosphoSiteiO75473.

Expressioni

Tissue specificityi

Expressed in skeletal muscle, placenta, spinal cord, and various region of brain. Expressed at the base of crypts in colonic and small mucosa stem cells. In premalignant cancer expression is not restricted to the cript base. Overexpressed in cancers of the ovary, colon and liver.3 Publications

Gene expression databases

BgeeiO75473.
CleanExiHS_LGR5.
GenevestigatoriO75473.

Organism-specific databases

HPAiHPA012530.

Interactioni

Subunit structurei

Identified in a complex composed of RNF43, LGR5 and RSPO1.2 Publications

Protein-protein interaction databases

BioGridi114119. 1 interaction.
STRINGi9606.ENSP00000266674.

Structurei

Secondary structure

1
907
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi39 – 435
Turni44 – 463
Beta strandi47 – 515
Beta strandi68 – 725
Beta strandi94 – 963
Turni107 – 1126
Beta strandi118 – 1203
Turni133 – 1364
Beta strandi142 – 1443
Turni155 – 1606
Beta strandi166 – 1683
Helixi179 – 1824
Beta strandi190 – 1923
Turni203 – 2086
Beta strandi214 – 2163
Turni227 – 2326
Beta strandi238 – 2403
Helixi251 – 2555
Beta strandi261 – 2633
Turni274 – 2796
Beta strandi285 – 2873
Turni298 – 3036
Beta strandi310 – 3134
Beta strandi331 – 3388
Helixi347 – 3504
Beta strandi356 – 3583
Beta strandi378 – 3803
Turni393 – 3964
Beta strandi402 – 4043
Turni415 – 4206
Beta strandi426 – 4283
Beta strandi446 – 4494
Beta strandi470 – 4723
Turni476 – 4783
Helixi480 – 4823
Helixi523 – 53311
Beta strandi534 – 5363
Beta strandi540 – 5423

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4BSRX-ray3.20A/B22-543[»]
4BSSX-ray3.20A/B/E/F22-543[»]
4BSTX-ray4.30A/B22-543[»]
4BSUX-ray3.20A/B/E/F22-543[»]
4KNGX-ray2.50A/B32-557[»]
ProteinModelPortaliO75473.
SMRiO75473. Positions 28-543.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 561540ExtracellularSequence AnalysisAdd
BLAST
Topological domaini583 – 59311CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini615 – 63824ExtracellularSequence AnalysisAdd
BLAST
Topological domaini660 – 68223CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini704 – 72219ExtracellularSequence AnalysisAdd
BLAST
Topological domaini744 – 76724CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini789 – 80214ExtracellularSequence AnalysisAdd
BLAST
Topological domaini824 – 90784CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei562 – 58221Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei594 – 61421Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei639 – 65921Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei683 – 70321Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei723 – 74321Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei768 – 78821Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei803 – 82321Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 6642LRRNTAdd
BLAST
Repeati67 – 9024LRR 1Add
BLAST
Repeati91 – 11222LRR 2Add
BLAST
Repeati115 – 13622LRR 3Add
BLAST
Repeati139 – 16022LRR 4Add
BLAST
Repeati163 – 18422LRR 5Add
BLAST
Repeati187 – 20822LRR 6Add
BLAST
Repeati211 – 23222LRR 7Add
BLAST
Repeati235 – 25622LRR 8Add
BLAST
Repeati258 – 27922LRR 9Add
BLAST
Repeati282 – 30322LRR 10Add
BLAST
Repeati306 – 32823LRR 11Add
BLAST
Repeati329 – 35022LRR 12Add
BLAST
Repeati353 – 37422LRR 13Add
BLAST
Repeati375 – 39622LRR 14Add
BLAST
Repeati399 – 42022LRR 15Add
BLAST
Repeati423 – 44624LRR 16Add
BLAST

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Contains 16 LRR (leucine-rich) repeats.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG4886.
GeneTreeiENSGT00760000119088.
HOGENOMiHOG000231829.
HOVERGENiHBG031675.
InParanoidiO75473.
KOiK04308.
OMAiLENIWDC.
OrthoDBiEOG7DNNTF.
PhylomeDBiO75473.
TreeFamiTF316814.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002131. Gphrmn_rcpt_fam.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
IPR026906. LRR_5.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF00560. LRR_1. 1 hit.
PF13306. LRR_5. 1 hit.
PF13855. LRR_8. 2 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
PRINTSiPR00373. GLYCHORMONER.
PR00237. GPCRRHODOPSN.
SMARTiSM00369. LRR_TYP. 8 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS51450. LRR. 15 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O75473) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDTSRLGVLL SLPVLLQLAT GGSSPRSGVL LRGCPTHCHC EPDGRMLLRV
60 70 80 90 100
DCSDLGLSEL PSNLSVFTSY LDLSMNNISQ LLPNPLPSLR FLEELRLAGN
110 120 130 140 150
ALTYIPKGAF TGLYSLKVLM LQNNQLRHVP TEALQNLRSL QSLRLDANHI
160 170 180 190 200
SYVPPSCFSG LHSLRHLWLD DNALTEIPVQ AFRSLSALQA MTLALNKIHH
210 220 230 240 250
IPDYAFGNLS SLVVLHLHNN RIHSLGKKCF DGLHSLETLD LNYNNLDEFP
260 270 280 290 300
TAIRTLSNLK ELGFHSNNIR SIPEKAFVGN PSLITIHFYD NPIQFVGRSA
310 320 330 340 350
FQHLPELRTL TLNGASQITE FPDLTGTANL ESLTLTGAQI SSLPQTVCNQ
360 370 380 390 400
LPNLQVLDLS YNLLEDLPSF SVCQKLQKID LRHNEIYEIK VDTFQQLLSL
410 420 430 440 450
RSLNLAWNKI AIIHPNAFST LPSLIKLDLS SNLLSSFPIT GLHGLTHLKL
460 470 480 490 500
TGNHALQSLI SSENFPELKV IEMPYAYQCC AFGVCENAYK ISNQWNKGDN
510 520 530 540 550
SSMDDLHKKD AGMFQAQDER DLEDFLLDFE EDLKALHSVQ CSPSPGPFKP
560 570 580 590 600
CEHLLDGWLI RIGVWTIAVL ALTCNALVTS TVFRSPLYIS PIKLLIGVIA
610 620 630 640 650
AVNMLTGVSS AVLAGVDAFT FGSFARHGAW WENGVGCHVI GFLSIFASES
660 670 680 690 700
SVFLLTLAAL ERGFSVKYSA KFETKAPFSS LKVIILLCAL LALTMAAVPL
710 720 730 740 750
LGGSKYGASP LCLPLPFGEP STMGYMVALI LLNSLCFLMM TIAYTKLYCN
760 770 780 790 800
LDKGDLENIW DCSMVKHIAL LLFTNCILNC PVAFLSFSSL INLTFISPEV
810 820 830 840 850
IKFILLVVVP LPACLNPLLY ILFNPHFKED LVSLRKQTYV WTRSKHPSLM
860 870 880 890 900
SINSDDVEKQ SCDSTQALVT FTSSSITYDL PPSSVPSPAY PVTESCHLSS

VAFVPCL
Length:907
Mass (Da):99,998
Last modified:November 1, 1998 - v1
Checksum:i822D5C5E6F0D9092
GO
Isoform 2 (identifier: O75473-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     263-286: Missing.

Show »
Length:883
Mass (Da):97,404
Checksum:i50B293FCFCAED440
GO
Isoform 3 (identifier: O75473-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     143-214: Missing.

Show »
Length:835
Mass (Da):92,006
Checksum:i352096C4523C1E2F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti90 – 901R → H in AAC77911. (PubMed:9849958)Curated
Sequence conflicti212 – 2121L → W in AAC77911. (PubMed:9849958)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti383 – 3831H → R.
Corresponds to variant rs12303775 [ dbSNP | Ensembl ].
VAR_049411
Natural varianti666 – 6661V → A.1 Publication
Corresponds to variant rs17109924 [ dbSNP | Ensembl ].
VAR_049412

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei143 – 21472Missing in isoform 3. 1 PublicationVSP_054782Add
BLAST
Alternative sequencei263 – 28624Missing in isoform 2. 1 PublicationVSP_037746Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF062006 mRNA. Translation: AAC28019.1.
AF061444 mRNA. Translation: AAC77911.1.
FN820440 mRNA. Translation: CBL95002.2.
AC078860 Genomic DNA. No translation available.
AC090116 Genomic DNA. No translation available.
BC096324 mRNA. Translation: AAH96324.1.
BC096325 mRNA. Translation: AAH96325.1.
BC096326 mRNA. Translation: AAH96326.1.
BC099650 mRNA. Translation: AAH99650.1.
CCDSiCCDS61194.1. [O75473-2]
CCDS61195.1. [O75473-3]
CCDS9000.1. [O75473-1]
PIRiJE0176.
RefSeqiNP_001264155.1. NM_001277226.1. [O75473-2]
NP_001264156.1. NM_001277227.1. [O75473-3]
NP_003658.1. NM_003667.3. [O75473-1]
UniGeneiHs.658889.

Genome annotation databases

GeneIDi8549.
KEGGihsa:8549.
UCSCiuc001swl.4. human. [O75473-1]
uc001swm.4. human. [O75473-2]
uc021rar.2. human.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF062006 mRNA. Translation: AAC28019.1 .
AF061444 mRNA. Translation: AAC77911.1 .
FN820440 mRNA. Translation: CBL95002.2 .
AC078860 Genomic DNA. No translation available.
AC090116 Genomic DNA. No translation available.
BC096324 mRNA. Translation: AAH96324.1 .
BC096325 mRNA. Translation: AAH96325.1 .
BC096326 mRNA. Translation: AAH96326.1 .
BC099650 mRNA. Translation: AAH99650.1 .
CCDSi CCDS61194.1. [O75473-2 ]
CCDS61195.1. [O75473-3 ]
CCDS9000.1. [O75473-1 ]
PIRi JE0176.
RefSeqi NP_001264155.1. NM_001277226.1. [O75473-2 ]
NP_001264156.1. NM_001277227.1. [O75473-3 ]
NP_003658.1. NM_003667.3. [O75473-1 ]
UniGenei Hs.658889.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4BSR X-ray 3.20 A/B 22-543 [» ]
4BSS X-ray 3.20 A/B/E/F 22-543 [» ]
4BST X-ray 4.30 A/B 22-543 [» ]
4BSU X-ray 3.20 A/B/E/F 22-543 [» ]
4KNG X-ray 2.50 A/B 32-557 [» ]
ProteinModelPortali O75473.
SMRi O75473. Positions 28-543.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114119. 1 interaction.
STRINGi 9606.ENSP00000266674.

Chemistry

GuidetoPHARMACOLOGYi 148.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei O75473.

Proteomic databases

MaxQBi O75473.
PaxDbi O75473.
PRIDEi O75473.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 8549.
KEGGi hsa:8549.
UCSCi uc001swl.4. human. [O75473-1 ]
uc001swm.4. human. [O75473-2 ]
uc021rar.2. human.

Organism-specific databases

CTDi 8549.
GeneCardsi GC12P071833.
HGNCi HGNC:4504. LGR5.
HPAi HPA012530.
MIMi 606667. gene.
neXtProti NX_O75473.
PharmGKBi PA28894.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG4886.
GeneTreei ENSGT00760000119088.
HOGENOMi HOG000231829.
HOVERGENi HBG031675.
InParanoidi O75473.
KOi K04308.
OMAi LENIWDC.
OrthoDBi EOG7DNNTF.
PhylomeDBi O75473.
TreeFami TF316814.

Enzyme and pathway databases

Reactomei REACT_200716. regulation of FZD by ubiquitination.

Miscellaneous databases

GeneWikii LGR5.
GenomeRNAii 8549.
NextBioi 32032.
PROi O75473.
SOURCEi Search...

Gene expression databases

Bgeei O75473.
CleanExi HS_LGR5.
Genevestigatori O75473.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002131. Gphrmn_rcpt_fam.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
IPR026906. LRR_5.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
PF00560. LRR_1. 1 hit.
PF13306. LRR_5. 1 hit.
PF13855. LRR_8. 2 hits.
PF01462. LRRNT. 1 hit.
[Graphical view ]
PRINTSi PR00373. GLYCHORMONER.
PR00237. GPCRRHODOPSN.
SMARTi SM00369. LRR_TYP. 8 hits.
SM00013. LRRNT. 1 hit.
[Graphical view ]
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS51450. LRR. 15 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and cloning of an orphan G protein-coupled receptor of the glycoprotein hormone receptor subfamily."
    McDonald T., Wang R., Bailey W., Xie G., Chen F., Caskey C.T., Liu Q.
    Biochem. Biophys. Res. Commun. 247:266-270(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Characterization of two LGR genes homologous to gonadotropin and thyrotropin receptors with extracellular leucine-rich repeats and a G protein-coupled, seven-transmembrane region."
    Hsu S.Y., Liang S.-G., Hsueh A.J.W.
    Mol. Endocrinol. 12:1830-1845(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Placenta.
  3. "Alternatively spliced transcript of the GPR49-mRNA occur in different tumor cell lines and soft tissue sarcoma."
    Rot S., Taubert H., Bache M., Vordermark D., Kappler M.
    Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
  4. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ALA-666.
  6. "Overexpression of orphan G-protein-coupled receptor, Gpr49, in human hepatocellular carcinomas with beta-catenin mutations."
    Yamamoto Y., Sakamoto M., Fujii G., Tsuiji H., Kenetaka K., Asaka M., Hirohashi S.
    Hepatology 37:528-533(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  7. "Identification of overexpression of orphan G protein-coupled receptor GPR49 in human colon and ovarian primary tumors."
    McClanahan T., Koseoglu S., Smith K., Grein J., Gustafson E., Black S., Kirschmeier P., Samatar A.A.
    Cancer Biol. Ther. 5:419-426(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  8. "Immunostaining of Lgr5, an intestinal stem cell marker, in normal and premalignant human gastrointestinal tissue."
    Becker L., Huang Q., Mashimo H.
    ScientificWorldJournal 8:1168-1176(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  9. "LGR4 and LGR5 are R-spondin receptors mediating Wnt/beta-catenin and Wnt/PCP signalling."
    Glinka A., Dolde C., Kirsch N., Huang Y.L., Kazanskaya O., Ingelfinger D., Boutros M., Cruciat C.M., Niehrs C.
    EMBO Rep. 12:1055-1061(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH RSPO1; RSPO2; RSPO3 AND RSPO4.
  10. Cited for: FUNCTION, INTERACTION WITH RSPO1; RSPO2; RSPO3 AND RSPO4.
  11. "R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling."
    Carmon K.S., Gong X., Lin Q., Thomas A., Liu Q.
    Proc. Natl. Acad. Sci. U.S.A. 108:11452-11457(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH RSPO1; RSPO2; RSPO3 AND RSPO4.
  12. Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH RSPO1.
  13. "Constitutive Internalization of the Leucine-rich G Protein-coupled Receptor-5 (LGR5) to the Trans-Golgi Network."
    Snyder J.C., Rochelle L.K., Lyerly H.K., Caron M.G., Barak L.S.
    J. Biol. Chem. 288:10286-10297(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, MUTAGENESIS OF SER-861 AND SER-864.
  14. "Structure of stem cell growth factor R-spondin 1 in complex with the ectodomain of its receptor LGR5."
    Peng W.C., de Lau W., Forneris F., Granneman J.C., Huch M., Clevers H., Gros P.
    Cell Rep. 3:1885-1892(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF 22-543 IN COMPLEX WITH RSPO1, FUNCTION, MUTAGENESIS OF ASP-146; ASP-170 AND ALA-190, DISULFIDE BONDS.
  15. "The structural basis of R-spondin recognition by LGR5 and RNF43."
    Chen P.H., Chen X., Lin Z., Fang D., He X.
    Genes Dev. 27:1345-1350(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 32-557 IN COMPLEX WITH RNF43 AND RSPO1, SUBUNIT, DISULFIDE BONDS, GLYCOSYLATION AT ASN-208.

Entry informationi

Entry nameiLGR5_HUMAN
AccessioniPrimary (citable) accession number: O75473
Secondary accession number(s): D8MCT0
, Q4VAM0, Q4VAM2, Q9UP75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: November 1, 1998
Last modified: October 29, 2014
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

LGR5 is used as a marker of adult tissue stem cells in the intestine, stomach, hair follicle, and mammary epithelium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3