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Protein

Zinc finger protein 324A

Gene

ZNF324

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation. May be involved in regulation of cell proliferation.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri257 – 279C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri285 – 307C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri313 – 335C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri341 – 363C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri425 – 447C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri453 – 475C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri481 – 503C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 324A
Alternative name(s):
Zinc finger protein ZF5128
Gene namesi
Name:ZNF324
Synonyms:ZNF324A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000083812.11
HGNCiHGNC:14096 ZNF324
MIMi617477 gene
neXtProtiNX_O75467

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000083812
PharmGKBiPA37839

Polymorphism and mutation databases

BioMutaiZNF324

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475331 – 553Zinc finger protein 324AAdd BLAST553

Proteomic databases

EPDiO75467
MaxQBiO75467
PaxDbiO75467
PeptideAtlasiO75467
PRIDEiO75467
ProteomicsDBi50026

PTM databases

iPTMnetiO75467
PhosphoSitePlusiO75467

Expressioni

Tissue specificityi

Expressed at high levels in the spleen, thymus, and PBMC, at low levels in the prostate, ovary, small intestine, colon (mucosal lining), placenta, lung, and pancreas, and very weakly expressed in the liver and kidney.1 Publication

Inductioni

Induced at the early stage of T cell activation. Regulated at the transcriptional level during the cell cycle. Induced at a maximum level in the S phase.1 Publication

Gene expression databases

BgeeiENSG00000083812
CleanExiHS_ZNF324
ExpressionAtlasiO75467 baseline and differential
GenevisibleiO75467 HS

Organism-specific databases

HPAiHPA039774

Interactioni

Protein-protein interaction databases

BioGridi117331, 25 interactors
IntActiO75467, 2 interactors
STRINGi9606.ENSP00000196482

Structurei

3D structure databases

ProteinModelPortaliO75467
SMRiO75467
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 72KRABPROSITE-ProRule annotationAdd BLAST72

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi130 – 135Nuclear localization signal1 Publication6

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri257 – 279C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri285 – 307C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri313 – 335C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri341 – 363C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri425 – 447C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri453 – 475C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri481 – 503C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00630000089829
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiO75467
KOiK09228
OMAiYRRVMLD
OrthoDBiEOG091G02KC
PhylomeDBiO75467
TreeFamiTF337574

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 9 hits
PS50157 ZINC_FINGER_C2H2_2, 9 hits

Sequencei

Sequence statusi: Complete.

O75467-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFEDVAVYF SQEEWGLLDT AQRALYRRVM LDNFALVASL GLSTSRPRVV
60 70 80 90 100
IQLERGEEPW VPSGTDTTLS RTTYRRRNPG SWSLTEDRDV SGEWPRAFPD
110 120 130 140 150
TPPGMTTSVF PVAGACHSVK SLQRQRGASP SRERKPTGVS VIYWERLLLG
160 170 180 190 200
SGSGQASVSL RLTSPLRPPE GVRLREKTLT EHALLGRQPR TPERQKPCAQ
210 220 230 240 250
EVPGRTFGSA QDLEAAGGRG HHRMGAVWQE PHRLLGGQEP STWDELGEAL
260 270 280 290 300
HAGEKSFECR ACSKVFVKSS DLLKHLRTHT GERPYECAQC GKAFSQTSHL
310 320 330 340 350
TQHQRIHSGE TPYACPVCGK AFRHSSSLVR HQRIHTAEKS FRCSECGKAF
360 370 380 390 400
SHGSNLSQHR KIHAGGRPYA CAQCGRRFCR NSHLIQHERT HTGEKPFVCA
410 420 430 440 450
LCGAAFSQGS SLFKHQRVHT GEKPFACPQC GRAFSHSSNL TQHQLLHTGE
460 470 480 490 500
RPFRCVDCGK AFAKGAVLLS HRRIHTGEKP FVCTQCGRAF RERPALFHHQ
510 520 530 540 550
RIHTGEKTVR RSRASLHPQA RSVAGASSEG APAKETEPTP ASGPAAVSQP

AEV
Length:553
Mass (Da):61,104
Last modified:November 1, 1998 - v1
Checksum:iBBCB5C469A13108F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF060503 mRNA Translation: AAC33716.1
AK092341 mRNA Translation: BAG52533.1
CH471135 Genomic DNA Translation: EAW72594.1
CCDSiCCDS12981.1
RefSeqiNP_055162.1, NM_014347.2
UniGeneiHs.515660

Genome annotation databases

EnsembliENST00000196482; ENSP00000196482; ENSG00000083812
ENST00000536459; ENSP00000444812; ENSG00000083812
GeneIDi25799
KEGGihsa:25799
UCSCiuc002qsw.3 human

Similar proteinsi

Entry informationi

Entry nameiZ324A_HUMAN
AccessioniPrimary (citable) accession number: O75467
Secondary accession number(s): B3KRX1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: November 1, 1998
Last modified: June 20, 2018
This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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