Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 324A

Gene

ZNF324

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri257 – 279C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri285 – 307C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri313 – 335C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri341 – 363C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri425 – 447C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri453 – 475C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri481 – 503C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000083812-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 324A
Alternative name(s):
Zinc finger protein ZF5128
Gene namesi
Name:ZNF324
Synonyms:ZNF324A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:14096. ZNF324.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000083812.
PharmGKBiPA37839.

Polymorphism and mutation databases

BioMutaiZNF324.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475331 – 553Zinc finger protein 324AAdd BLAST553

Proteomic databases

EPDiO75467.
MaxQBiO75467.
PaxDbiO75467.
PeptideAtlasiO75467.
PRIDEiO75467.

PTM databases

iPTMnetiO75467.
PhosphoSitePlusiO75467.

Expressioni

Gene expression databases

BgeeiENSG00000083812.
CleanExiHS_ZNF324.
ExpressionAtlasiO75467. baseline and differential.
GenevisibleiO75467. HS.

Organism-specific databases

HPAiHPA039774.

Interactioni

Protein-protein interaction databases

BioGridi117331. 23 interactors.
IntActiO75467. 2 interactors.
STRINGi9606.ENSP00000196482.

Structurei

3D structure databases

ProteinModelPortaliO75467.
SMRiO75467.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 72KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri257 – 279C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri285 – 307C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri313 – 335C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri341 – 363C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri425 – 447C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri453 – 475C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri481 – 503C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000130002.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiO75467.
KOiK09228.
OMAiYRRVMLD.
OrthoDBiEOG091G02KC.
PhylomeDBiO75467.
TreeFamiTF337574.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 9 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O75467-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFEDVAVYF SQEEWGLLDT AQRALYRRVM LDNFALVASL GLSTSRPRVV
60 70 80 90 100
IQLERGEEPW VPSGTDTTLS RTTYRRRNPG SWSLTEDRDV SGEWPRAFPD
110 120 130 140 150
TPPGMTTSVF PVAGACHSVK SLQRQRGASP SRERKPTGVS VIYWERLLLG
160 170 180 190 200
SGSGQASVSL RLTSPLRPPE GVRLREKTLT EHALLGRQPR TPERQKPCAQ
210 220 230 240 250
EVPGRTFGSA QDLEAAGGRG HHRMGAVWQE PHRLLGGQEP STWDELGEAL
260 270 280 290 300
HAGEKSFECR ACSKVFVKSS DLLKHLRTHT GERPYECAQC GKAFSQTSHL
310 320 330 340 350
TQHQRIHSGE TPYACPVCGK AFRHSSSLVR HQRIHTAEKS FRCSECGKAF
360 370 380 390 400
SHGSNLSQHR KIHAGGRPYA CAQCGRRFCR NSHLIQHERT HTGEKPFVCA
410 420 430 440 450
LCGAAFSQGS SLFKHQRVHT GEKPFACPQC GRAFSHSSNL TQHQLLHTGE
460 470 480 490 500
RPFRCVDCGK AFAKGAVLLS HRRIHTGEKP FVCTQCGRAF RERPALFHHQ
510 520 530 540 550
RIHTGEKTVR RSRASLHPQA RSVAGASSEG APAKETEPTP ASGPAAVSQP

AEV
Length:553
Mass (Da):61,104
Last modified:November 1, 1998 - v1
Checksum:iBBCB5C469A13108F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF060503 mRNA. Translation: AAC33716.1.
AK092341 mRNA. Translation: BAG52533.1.
CH471135 Genomic DNA. Translation: EAW72594.1.
CCDSiCCDS12981.1.
RefSeqiNP_055162.1. NM_014347.2.
UniGeneiHs.515660.

Genome annotation databases

EnsembliENST00000196482; ENSP00000196482; ENSG00000083812.
ENST00000536459; ENSP00000444812; ENSG00000083812.
GeneIDi25799.
KEGGihsa:25799.
UCSCiuc002qsw.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF060503 mRNA. Translation: AAC33716.1.
AK092341 mRNA. Translation: BAG52533.1.
CH471135 Genomic DNA. Translation: EAW72594.1.
CCDSiCCDS12981.1.
RefSeqiNP_055162.1. NM_014347.2.
UniGeneiHs.515660.

3D structure databases

ProteinModelPortaliO75467.
SMRiO75467.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117331. 23 interactors.
IntActiO75467. 2 interactors.
STRINGi9606.ENSP00000196482.

PTM databases

iPTMnetiO75467.
PhosphoSitePlusiO75467.

Polymorphism and mutation databases

BioMutaiZNF324.

Proteomic databases

EPDiO75467.
MaxQBiO75467.
PaxDbiO75467.
PeptideAtlasiO75467.
PRIDEiO75467.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000196482; ENSP00000196482; ENSG00000083812.
ENST00000536459; ENSP00000444812; ENSG00000083812.
GeneIDi25799.
KEGGihsa:25799.
UCSCiuc002qsw.3. human.

Organism-specific databases

CTDi25799.
GeneCardsiZNF324.
HGNCiHGNC:14096. ZNF324.
HPAiHPA039774.
neXtProtiNX_O75467.
OpenTargetsiENSG00000083812.
PharmGKBiPA37839.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000130002.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiO75467.
KOiK09228.
OMAiYRRVMLD.
OrthoDBiEOG091G02KC.
PhylomeDBiO75467.
TreeFamiTF337574.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000083812-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii25799.
PROiO75467.

Gene expression databases

BgeeiENSG00000083812.
CleanExiHS_ZNF324.
ExpressionAtlasiO75467. baseline and differential.
GenevisibleiO75467. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 9 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZ324A_HUMAN
AccessioniPrimary (citable) accession number: O75467
Secondary accession number(s): B3KRX1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: November 1, 1998
Last modified: November 2, 2016
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.