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Protein

P antigen family member 1

Gene

PAGE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Miscellaneous

This gene belongs to a multigene family expressed in a large variety of tumors whereas in normal tissues, expression is restricted to germ cells. These genes organized in clustered repeats, have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

GO - Biological processi

  • cellular defense response Source: ProtInc

Names & Taxonomyi

Protein namesi
Recommended name:
P antigen family member 1
Short name:
PAGE-1
Alternative name(s):
AL5
G antigen 9
Short name:
GAGE-9
G antigen family B member 1
Prostate-associated gene 1 protein
Gene namesi
Name:PAGE1
Synonyms:GAGE9, GAGEB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000068985.4.
HGNCiHGNC:4107. PAGE1.

Pathology & Biotechi

Organism-specific databases

DisGeNETi8712.
OpenTargetsiENSG00000068985.
PharmGKBiPA28522.

Polymorphism and mutation databases

BioMutaiPAGE1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001483471 – 146P antigen family member 1Add BLAST146

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei63PhosphoserineCombined sources1
Modified residuei105PhosphoserineCombined sources1
Modified residuei144PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO75459.
PaxDbiO75459.
PeptideAtlasiO75459.
PRIDEiO75459.

PTM databases

iPTMnetiO75459.
PhosphoSitePlusiO75459.

Expressioni

Tissue specificityi

Isolated from prostate cancer cell lines; expression associated with progression to androgen insensitive phenotype. Expressed in normal testis and at lower level in normal placenta.

Gene expression databases

BgeeiENSG00000068985.
CleanExiHS_PAGE1.
GenevisibleiO75459. HS.

Organism-specific databases

HPAiHPA003473.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FAM9BQ8IZU03EBI-2559100,EBI-10175124

Protein-protein interaction databases

BioGridi114254. 27 interactors.
IntActiO75459. 2 interactors.
STRINGi9606.ENSP00000365320.

Structurei

3D structure databases

ProteinModelPortaliO75459.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GAGE family.Curated

Phylogenomic databases

eggNOGiENOG410IUTE. Eukaryota.
ENOG4110PV5. LUCA.
GeneTreeiENSGT00900000141202.
HOGENOMiHOG000237345.
HOVERGENiHBG056227.
InParanoidiO75459.
OMAiCLRNEEQ.
OrthoDBiEOG091G0UGV.
PhylomeDBiO75459.
TreeFamiTF340669.

Family and domain databases

InterProiView protein in InterPro
IPR031320. GAGE.
IPR008625. GAGE_fam.
PANTHERiPTHR14047. PTHR14047. 2 hits.
PfamiView protein in Pfam
PF05831. GAGE. 2 hits.
SMARTiView protein in SMART
SM01379. GAGE. 2 hits.

Sequencei

Sequence statusi: Complete.

O75459-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFLRRLIYR RRPMIYVESS EESSDEQPDE VESPTQSQDS TPAEEREDEG
60 70 80 90 100
ASAAQGQEPE ADSQELVQPK TGCELGDGPD TKRVCLRNEE QMKLPAEGPE
110 120 130 140
PEADSQEQVH PKTGCERGDG PDVQELGLPN PEEVKTPEED EGQSQP
Length:146
Mass (Da):16,150
Last modified:October 3, 2006 - v2
Checksum:iE6C7BA94D898DCB2
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02776775L → P1 PublicationCorresponds to variant dbSNP:rs1055197Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF058989 mRNA. Translation: AAC25990.1.
CR542084 mRNA. Translation: CAG46881.1.
AC231643 Genomic DNA. No translation available.
BC004861 mRNA. Translation: AAH04861.1.
CCDSiCCDS14327.1.
RefSeqiNP_003776.2. NM_003785.3.
XP_011542300.1. XM_011543998.2.
UniGeneiHs.128231.

Genome annotation databases

EnsembliENST00000376150; ENSP00000365320; ENSG00000068985.
GeneIDi8712.
KEGGihsa:8712.
UCSCiuc004dom.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPAGE1_HUMAN
AccessioniPrimary (citable) accession number: O75459
Secondary accession number(s): Q6FGM3, Q9BSS7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: October 3, 2006
Last modified: October 25, 2017
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE members made impossible to separate products of paralogous genes from polymorph products. PubMed:18179644 presented a new GAGE gene nomenclature based on the identified genes and their products.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families