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Protein

P antigen family member 1

Gene

PAGE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • cellular defense response Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
P antigen family member 1
Short name:
PAGE-1
Alternative name(s):
AL5
G antigen 9
Short name:
GAGE-9
G antigen family B member 1
Prostate-associated gene 1 protein
Gene namesi
Name:PAGE1
Synonyms:GAGE9, GAGEB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:4107. PAGE1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28522.

Polymorphism and mutation databases

BioMutaiPAGE1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 146146P antigen family member 1PRO_0000148347Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei63 – 631PhosphoserineCombined sources
Modified residuei144 – 1441PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO75459.
PaxDbiO75459.
PeptideAtlasiO75459.
PRIDEiO75459.

PTM databases

iPTMnetiO75459.
PhosphoSiteiO75459.

Expressioni

Tissue specificityi

Isolated from prostate cancer cell lines; expression associated with progression to androgen insensitive phenotype. Expressed in normal testis and at lower level in normal placenta.

Gene expression databases

BgeeiO75459.
CleanExiHS_PAGE1.
GenevisibleiO75459. HS.

Organism-specific databases

HPAiHPA003473.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FAM9BQ8IZU03EBI-2559100,EBI-10175124

Protein-protein interaction databases

BioGridi114254. 2 interactions.
IntActiO75459. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliO75459.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GAGE family.Curated

Phylogenomic databases

eggNOGiENOG410IUTE. Eukaryota.
ENOG4110PV5. LUCA.
GeneTreeiENSGT00840000129924.
HOGENOMiHOG000237345.
HOVERGENiHBG056227.
InParanoidiO75459.
OMAiCLRNEEQ.
OrthoDBiEOG79SF00.
PhylomeDBiO75459.
TreeFamiTF340669.

Family and domain databases

InterProiIPR031320. GAGE.
IPR008625. GAGE_fam.
[Graphical view]
PANTHERiPTHR14047. PTHR14047. 2 hits.
PfamiPF05831. GAGE. 2 hits.
[Graphical view]
SMARTiSM01379. GAGE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O75459-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFLRRLIYR RRPMIYVESS EESSDEQPDE VESPTQSQDS TPAEEREDEG
60 70 80 90 100
ASAAQGQEPE ADSQELVQPK TGCELGDGPD TKRVCLRNEE QMKLPAEGPE
110 120 130 140
PEADSQEQVH PKTGCERGDG PDVQELGLPN PEEVKTPEED EGQSQP
Length:146
Mass (Da):16,150
Last modified:October 3, 2006 - v2
Checksum:iE6C7BA94D898DCB2
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti75 – 751L → P.1 Publication
Corresponds to variant rs1055197 [ dbSNP | Ensembl ].
VAR_027767

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF058989 mRNA. Translation: AAC25990.1.
CR542084 mRNA. Translation: CAG46881.1.
AC231643 Genomic DNA. No translation available.
BC004861 mRNA. Translation: AAH04861.1.
CCDSiCCDS14327.1.
RefSeqiNP_003776.2. NM_003785.3.
XP_011542300.1. XM_011543998.1.
XP_011542301.1. XM_011543999.1.
UniGeneiHs.128231.

Genome annotation databases

EnsembliENST00000376150; ENSP00000365320; ENSG00000068985.
GeneIDi8712.
KEGGihsa:8712.
UCSCiuc004dom.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF058989 mRNA. Translation: AAC25990.1.
CR542084 mRNA. Translation: CAG46881.1.
AC231643 Genomic DNA. No translation available.
BC004861 mRNA. Translation: AAH04861.1.
CCDSiCCDS14327.1.
RefSeqiNP_003776.2. NM_003785.3.
XP_011542300.1. XM_011543998.1.
XP_011542301.1. XM_011543999.1.
UniGeneiHs.128231.

3D structure databases

ProteinModelPortaliO75459.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114254. 2 interactions.
IntActiO75459. 2 interactions.

PTM databases

iPTMnetiO75459.
PhosphoSiteiO75459.

Polymorphism and mutation databases

BioMutaiPAGE1.

Proteomic databases

MaxQBiO75459.
PaxDbiO75459.
PeptideAtlasiO75459.
PRIDEiO75459.

Protocols and materials databases

DNASUi8712.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376150; ENSP00000365320; ENSG00000068985.
GeneIDi8712.
KEGGihsa:8712.
UCSCiuc004dom.4. human.

Organism-specific databases

CTDi8712.
GeneCardsiPAGE1.
HGNCiHGNC:4107. PAGE1.
HPAiHPA003473.
MIMi300288. gene.
neXtProtiNX_O75459.
PharmGKBiPA28522.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IUTE. Eukaryota.
ENOG4110PV5. LUCA.
GeneTreeiENSGT00840000129924.
HOGENOMiHOG000237345.
HOVERGENiHBG056227.
InParanoidiO75459.
OMAiCLRNEEQ.
OrthoDBiEOG79SF00.
PhylomeDBiO75459.
TreeFamiTF340669.

Miscellaneous databases

GenomeRNAii8712.
PROiO75459.
SOURCEiSearch...

Gene expression databases

BgeeiO75459.
CleanExiHS_PAGE1.
GenevisibleiO75459. HS.

Family and domain databases

InterProiIPR031320. GAGE.
IPR008625. GAGE_fam.
[Graphical view]
PANTHERiPTHR14047. PTHR14047. 2 hits.
PfamiPF05831. GAGE. 2 hits.
[Graphical view]
SMARTiSM01379. GAGE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of PAGE-1 and GAGE-7: new genes expressed in the LNCaP prostate cancer progression model that share homology with melanoma-associated antigens."
    Chen M.E., Lin S.-H., Chung L.W.K., Sikes R.A.
    J. Biol. Chem. 273:17618-17625(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT PRO-75.
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-63 AND SER-144, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members."
    Gjerstorff M.F., Ditzel H.J.
    Tissue Antigens 71:187-192(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GAGE FAMILY.

Entry informationi

Entry nameiPAGE1_HUMAN
AccessioniPrimary (citable) accession number: O75459
Secondary accession number(s): Q6FGM3, Q9BSS7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: October 3, 2006
Last modified: June 8, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

This gene belongs to a multigene family expressed in a large variety of tumors whereas in normal tissues, expression is restricted to germ cells. These genes organized in clustered repeats, have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

Caution

The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE members made impossible to separate products of paralogous genes from polymorph products. PubMed:18179644 presented a new GAGE gene nomenclature based on the identified genes and their products.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.