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Protein

Alpha-tectorin

Gene

TECTA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals.By similarity

GO - Molecular functioni

GO - Biological processi

  • cell-matrix adhesion Source: InterPro
  • sensory perception of sound Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Hearing

Enzyme and pathway databases

BioCyciZFISH:ENSG00000109927-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-tectorin
Gene namesi
Name:TECTA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:11720. TECTA.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Extracellular matrix, Membrane, Secreted

Pathology & Biotechi

Involvement in diseasei

Deafness, autosomal dominant, 12 (DFNA12)9 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
See also OMIM:601543
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_066076197D → N in DFNA12. 1 Publication1
Natural variantiVAR_066077211F → S in DFNA12. 1 Publication1
Natural variantiVAR_066078317V → E in DFNA12. 1 Publication1
Natural variantiVAR_066079362S → C in DFNA12. 1 PublicationCorresponds to variant rs779123206dbSNPEnsembl.1
Natural variantiVAR_066080465N → K in DFNA12. 1 Publication1
Natural variantiVAR_066081562T → M in DFNA12. 1 PublicationCorresponds to variant rs779401654dbSNPEnsembl.1
Natural variantiVAR_066082815T → M in DFNA12. 1 PublicationCorresponds to variant rs111759871dbSNPEnsembl.1
Natural variantiVAR_066083886N → S in DFNA12. 1 PublicationCorresponds to variant rs146175803dbSNPEnsembl.1
Natural variantiVAR_0660841036C → Y in DFNA12. 1 PublicationCorresponds to variant rs772606235dbSNPEnsembl.1
Natural variantiVAR_0189701057C → S in DFNA12; progressive deafness with late onset. 1 PublicationCorresponds to variant rs121909059dbSNPEnsembl.1
Natural variantiVAR_0660851098A → V in DFNA12. 1 PublicationCorresponds to variant rs761524812dbSNPEnsembl.1
Natural variantiVAR_0660861136D → H in DFNA12. 1 PublicationCorresponds to variant rs147890616dbSNPEnsembl.1
Natural variantiVAR_0660871248P → L in DFNA12. 1 PublicationCorresponds to variant rs138768918dbSNPEnsembl.1
Natural variantiVAR_0660881509C → G in DFNA12. 1 Publication1
Natural variantiVAR_0660891517C → R in DFNA12. 1 Publication1
Natural variantiVAR_0189711619C → S in DFNA12. 1 PublicationCorresponds to variant rs28939691dbSNPEnsembl.1
Natural variantiVAR_0660901791P → R in DFNA12. 1 PublicationCorresponds to variant rs754213928dbSNPEnsembl.1
Natural variantiVAR_0189731820L → F in DFNA12; prelingual and stable deafness. 1 PublicationCorresponds to variant rs281865415dbSNPEnsembl.1
Natural variantiVAR_0189741824G → D in DFNA12; prelingual and stable deafness. 1 PublicationCorresponds to variant rs267607107dbSNPEnsembl.1
Natural variantiVAR_0189751837C → G in DFNA12; postlingual and progressive. 2 PublicationsCorresponds to variant rs121909061dbSNPEnsembl.1
Natural variantiVAR_0660911837C → R in DFNA12. 1 PublicationCorresponds to variant rs121909061dbSNPEnsembl.1
Natural variantiVAR_0660921866T → M in DFNA12. 2 PublicationsCorresponds to variant rs140236996dbSNPEnsembl.1
Natural variantiVAR_0660931867H → R in DFNA12. 1 Publication1
Natural variantiVAR_0189761870Y → C in DFNA12; prelingual and stable deafness. 1 PublicationCorresponds to variant rs28939690dbSNPEnsembl.1
Natural variantiVAR_0660941890R → C in DFNA12. 2 PublicationsCorresponds to variant rs121909063dbSNPEnsembl.1
Natural variantiVAR_0660951898C → R in DFNA12. 1 Publication1
Natural variantiVAR_0660961947R → C in DFNA12. 1 Publication1
Natural variantiVAR_0660972009I → T in DFNA12. 1 Publication1
Natural variantiVAR_0189772021R → H in DFNA12; prelingual and stable deafness. 1 PublicationCorresponds to variant rs121909062dbSNPEnsembl.1
Deafness, autosomal recessive, 21 (DFNB21)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
See also OMIM:603629

Keywords - Diseasei

Deafness, Disease mutation, Non-syndromic deafness

Organism-specific databases

DisGeNETi7007.
MalaCardsiTECTA.
MIMi601543. phenotype.
603629. phenotype.
OpenTargetsiENSG00000109927.
Orphaneti90635. Autosomal dominant non-syndromic sensorineural deafness type DFNA.
90636. Autosomal recessive non-syndromic sensorineural deafness type DFNB.

Polymorphism and mutation databases

BioMutaiTECTA.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000004173523 – 2091Alpha-tectorinAdd BLAST2069
PropeptideiPRO_00000417362092 – 2155Removed in mature formSequence analysisAdd BLAST64

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi34N-linked (GlcNAc...)Sequence analysis1
Glycosylationi187N-linked (GlcNAc...)Sequence analysis1
Glycosylationi215N-linked (GlcNAc...)Sequence analysis1
Glycosylationi278N-linked (GlcNAc...)Sequence analysis1
Glycosylationi455N-linked (GlcNAc...)Sequence analysis1
Glycosylationi506N-linked (GlcNAc...)Sequence analysis1
Glycosylationi528N-linked (GlcNAc...)Sequence analysis1
Glycosylationi560N-linked (GlcNAc...)Sequence analysis1
Glycosylationi670N-linked (GlcNAc...)Sequence analysis1
Glycosylationi687N-linked (GlcNAc...)Sequence analysis1
Glycosylationi813N-linked (GlcNAc...)Sequence analysis1
Glycosylationi843N-linked (GlcNAc...)Sequence analysis1
Glycosylationi855N-linked (GlcNAc...)Sequence analysis1
Glycosylationi898N-linked (GlcNAc...)Sequence analysis1
Glycosylationi920N-linked (GlcNAc...)Sequence analysis1
Glycosylationi931N-linked (GlcNAc...)Sequence analysis1
Glycosylationi949N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1048N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1235N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1364N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1538N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1565N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1717 ↔ 1775By similarity
Disulfide bondi1741 ↔ 1784By similarity
Glycosylationi1756N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1772N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1786 ↔ 1818By similarity
Glycosylationi1794N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1806 ↔ 1898By similarity
Disulfide bondi1837 ↔ 1857By similarity
Glycosylationi1851N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1864N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1880N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1920N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1939N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1980 ↔ 2040PROSITE-ProRule annotation
Disulfide bondi2001 ↔ 2056By similarity
Disulfide bondi2045 ↔ 2052By similarity
Lipidationi2091GPI-anchor amidated asparagineSequence analysis1

Post-translational modificationi

The presence of a hydrophobic C-terminus preceded by a potential cleavage site strongly suggests that tectorins are synthesized as glycosylphosphatidylinositol-linked, membrane-bound precursors. Tectorins are targeted to the apical surface of the inner ear epithelia by the lipid and proteolytically released into the extracellular compartment.

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiO75443.
PeptideAtlasiO75443.
PRIDEiO75443.

PTM databases

iPTMnetiO75443.
PhosphoSitePlusiO75443.

Expressioni

Gene expression databases

BgeeiENSG00000109927.
CleanExiHS_TECTA.
GenevisibleiO75443. HS.

Organism-specific databases

HPAiHPA018870.

Interactioni

Subunit structurei

May form homomeric filament after self-association or heteromeric filament after association with beta-tectorin. Interacts with CEACAM16.1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000264037.

Structurei

3D structure databases

ProteinModelPortaliO75443.
SMRiO75443.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini98 – 252NIDOPROSITE-ProRule annotationAdd BLAST155
Domaini260 – 314VWFCAdd BLAST55
Domaini321 – 540VWFD 1PROSITE-ProRule annotationAdd BLAST220
Domaini597 – 650TIL 1Add BLAST54
Domaini712 – 929VWFD 2PROSITE-ProRule annotationAdd BLAST218
Domaini984 – 1036TIL 2Add BLAST53
Domaini1099 – 1317VWFD 3PROSITE-ProRule annotationAdd BLAST219
Domaini1372 – 1425TIL 3Add BLAST54
Domaini1486 – 1694VWFD 4PROSITE-ProRule annotationAdd BLAST209
Domaini1805 – 2059ZPPROSITE-ProRule annotationAdd BLAST255

Domaini

Zona pellucida domain may enable to form filaments.

Sequence similaritiesi

Contains 1 NIDO domain.PROSITE-ProRule annotation
Contains 1 VWFC domain.Curated
Contains 4 VWFD domains.PROSITE-ProRule annotation
Contains 1 ZP domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG1216. Eukaryota.
KOG4291. Eukaryota.
ENOG410YR2E. LUCA.
GeneTreeiENSGT00760000118896.
HOGENOMiHOG000168220.
HOVERGENiHBG079244.
InParanoidiO75443.
KOiK18273.
OMAiYSCKINC.
OrthoDBiEOG091G002A.
PhylomeDBiO75443.
TreeFamiTF300299.

Family and domain databases

InterProiIPR000742. EGF-like_dom.
IPR003886. NIDO_dom.
IPR033026. TECTA.
IPR002919. TIL_dom.
IPR025615. TILa_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001007. VWF_dom.
IPR001846. VWF_type-D.
IPR001507. ZP_dom.
IPR017977. ZP_dom_CS.
[Graphical view]
PANTHERiPTHR11339:SF235. PTHR11339:SF235. 2 hits.
PfamiPF08742. C8. 4 hits.
PF06119. NIDO. 1 hit.
PF01826. TIL. 3 hits.
PF12714. TILa. 2 hits.
PF00094. VWD. 4 hits.
PF00100. Zona_pellucida. 1 hit.
[Graphical view]
SMARTiSM00832. C8. 4 hits.
SM00181. EGF. 3 hits.
SM00539. NIDO. 1 hit.
SM00215. VWC_out. 3 hits.
SM00216. VWD. 4 hits.
SM00241. ZP. 1 hit.
[Graphical view]
SUPFAMiSSF57567. SSF57567. 3 hits.
PROSITEiPS51220. NIDO. 1 hit.
PS51233. VWFD. 4 hits.
PS00682. ZP_1. 1 hit.
PS51034. ZP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O75443-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNYSSFLRIW VSFIFALVQH QAQPRELMYP FWQNDTKTPK VDDGSSSEIK
60 70 80 90 100
LAIPVFFFGV PYRTVYVNNN GVVSFNVLVS QFTPESFPLT DGRAFVAPFW
110 120 130 140 150
ADVHNGIRGE IYYRETMEPA ILKRATKDIR KYFKDMATFS ATWVFIVTWE
160 170 180 190 200
EVTFYGGSST TPVNTFQAVL VSDGSYTFTL FNYYEINWTT GTASGGDPLT
210 220 230 240 250
GLGGVMAQAG FNGGNLTNFF SLPGSRTPEI VNIQETTNVN VPGRWAFKVD
260 270 280 290 300
GKEIDPANGC TSRGQFLRRG EVFWDDLNCT VKCRCLDFNN EIYCQEASCS
310 320 330 340 350
PYEVCEPKGK FFYCSAVETS TCVVFGEPHY HTFDGFLFHF QGSCAYLLAR
360 370 380 390 400
QCLQTSSLPF FSVEAKNEHR RGSAVSWVKE LSVEVNGYKI LIPKGSYGRV
410 420 430 440 450
KVNDLVTSLP VTLDLGTVKI YQSGISTAVE TDFGLLVTFD GQHYASISVP
460 470 480 490 500
GSYINSTCGL CGNYNKNPLD DFLRPDGRPA MSVLDLGESW RVYHADWKCD
510 520 530 540 550
SGCVDNCTQC DAATEALYFG SDYCGFLNKT DGPLWECGTV VDPTAFVHSC
560 570 580 590 600
VYDLCSVRDN GTLLCQAIQA YALVCQALGI PIGDWRTQTG CVSTVQCPSF
610 620 630 640 650
SHYSVCTSSC PDTCSDLTAS RNCATPCTEG CECNQGFVLS TSQCVPLHKC
660 670 680 690 700
GCDFDGHYYT MGEFFWATAN CTVQCLCEEG GDVYCFNKTC GSGEVCAVED
710 720 730 740 750
GYQGCFPKRE TVCLLSQNQV LHTFDGASYA FPSEFSYTLL KTCPERPEYL
760 770 780 790 800
EIDINKKKPD AGPAWLRGLR ILVADQEVKI GGIGASEVKL NGQEVELPFF
810 820 830 840 850
HPSGKLEIYR NKNSTTVESK GVVTVQYSDI GLLYIRLSTT YFNCTGGLCG
860 870 880 890 900
FYNANASDEF CLPNGKCTDN LAVFLESWTT FEEICNGECG DLLKACNNDS
910 920 930 940 950
ELLKFYRSRS RCGIINDPSN SSFLECHGVV NVTAYYRTCL FRLCQSGGNE
960 970 980 990 1000
SELCDSVARY ASACKNADVE VGPWRTYDFC PLECPENSHF EECITCTETC
1010 1020 1030 1040 1050
ETLTLGPICV DSCSEGCQCD EGYALLGSQC VTRSECGCNF EGHQLATNET
1060 1070 1080 1090 1100
FWVDLDCQIF CYCSGTDNRV HCETIPCKDD EYCMEEGGLY YCQARTDASC
1110 1120 1130 1140 1150
IVSGYGHYLT FDGFPFDFQT SCPLILCTTG SRPSSDSFPK FVVTAKNEDR
1160 1170 1180 1190 1200
DPSLALWVKQ VDVTVFGYSI VIHRAYKHTV LVNSERLYLP LKLGQGKINI
1210 1220 1230 1240 1250
FSFGFHVVVE TDFGLKVVYD WKTFLSITVP RSMQNSTYGL CGRYNGNPDD
1260 1270 1280 1290 1300
DLEMPMGLLA SSVNEFGQSW VKRDTFCQVG CGDRCPSCAK VEGFSKVQQL
1310 1320 1330 1340 1350
CSLIPNQNAA FSKCHSKVNP TFFYKNCLFD SCIDGGAVQT ACSWLQNYAS
1360 1370 1380 1390 1400
TCQTQGITVT GWRNYTSCTV TCPPNSHYES CVSVCQPRCA AIRLKSDCSH
1410 1420 1430 1440 1450
YCVEGCHCDA GYVLNGKSCI LPHSCGCYSD GKYYEPKQLF WNSDCTRRCR
1460 1470 1480 1490 1500
CFRRNVIQCD PRQCKSDEEC ALRNGVRGCF STKTSYCLAA GGGVFRTFDG
1510 1520 1530 1540 1550
AFLRFPANCA FVLSTICQKL PDISFQLIIN FDKWSAPNLT IISPVYFYIN
1560 1570 1580 1590 1600
EEQILINDRN TVKVNGTQVN VPFITGLATK IYSSEGFLVI DTSPDIQIYY
1610 1620 1630 1640 1650
NGFNVIKISI SERLQNKVCG LCGNFNGDLT DDYVTLRGKP VVSSVVLAQS
1660 1670 1680 1690 1700
WKTNGMQKRP LAPSCNELQF SQYAAMCDNV HIQKMQGDGY CLKLTDMKGF
1710 1720 1730 1740 1750
FQPCYGLLDP LPFYESCYLD GCYSHKKFQL CGSLAAYGEA CRSFGILSTE
1760 1770 1780 1790 1800
WIEKENCSGV VEDPCVGADC PNRTCELGNG RELCGCIEPP PYGNNSHDII
1810 1820 1830 1840 1850
DAEVTCKAAQ MEVSISKCKL FQLGFEREGV RINDRQCTGI EGEDFISFQI
1860 1870 1880 1890 1900
NNTKGNCGNI VQSNGTHIMY KNTLWIESAN NTGNIITRDR TINVEFSCAY
1910 1920 1930 1940 1950
ELDIKISLDS VVKPMLSVIN LTVPTQEGSF ITKMALYKNA SYKHPYRQGE
1960 1970 1980 1990 2000
VVLTTRDVLY VGVFVVGADA THLILTLNKC YATPTRDSND KLRYFIIEGG
2010 2020 2030 2040 2050
CQNLKDNTIG IEENAVSLTC RFHVTVFKFI GDYDEVHLHC AVSLCDSEKY
2060 2070 2080 2090 2100
SCKITCPHNS RIATDYTKEP KEQIISVGPI RRKRLDWCED NGGCEQICTS
2110 2120 2130 2140 2150
RVDGPLCSCV TGTLQEDGKS CRASNSSMEL QVWTLLLIMI QISLWHFVYK

SGTTS
Length:2,155
Mass (Da):239,527
Last modified:November 30, 2010 - v3
Checksum:iA7CB1CD9E7C594C3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05750019Q → R.Corresponds to variant rs35507522dbSNPEnsembl.1
Natural variantiVAR_066076197D → N in DFNA12. 1 Publication1
Natural variantiVAR_066077211F → S in DFNA12. 1 Publication1
Natural variantiVAR_036423284R → H in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_066078317V → E in DFNA12. 1 Publication1
Natural variantiVAR_066079362S → C in DFNA12. 1 PublicationCorresponds to variant rs779123206dbSNPEnsembl.1
Natural variantiVAR_018968371R → G.2 PublicationsCorresponds to variant rs612969dbSNPEnsembl.1
Natural variantiVAR_066080465N → K in DFNA12. 1 Publication1
Natural variantiVAR_066081562T → M in DFNA12. 1 PublicationCorresponds to variant rs779401654dbSNPEnsembl.1
Natural variantiVAR_036424771I → N in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_036425813N → T in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_066082815T → M in DFNA12. 1 PublicationCorresponds to variant rs111759871dbSNPEnsembl.1
Natural variantiVAR_066083886N → S in DFNA12. 1 PublicationCorresponds to variant rs146175803dbSNPEnsembl.1
Natural variantiVAR_018969932V → A.2 PublicationsCorresponds to variant rs520805dbSNPEnsembl.1
Natural variantiVAR_0660841036C → Y in DFNA12. 1 PublicationCorresponds to variant rs772606235dbSNPEnsembl.1
Natural variantiVAR_0189701057C → S in DFNA12; progressive deafness with late onset. 1 PublicationCorresponds to variant rs121909059dbSNPEnsembl.1
Natural variantiVAR_0660851098A → V in DFNA12. 1 PublicationCorresponds to variant rs761524812dbSNPEnsembl.1
Natural variantiVAR_0660861136D → H in DFNA12. 1 PublicationCorresponds to variant rs147890616dbSNPEnsembl.1
Natural variantiVAR_0660871248P → L in DFNA12. 1 PublicationCorresponds to variant rs138768918dbSNPEnsembl.1
Natural variantiVAR_0660881509C → G in DFNA12. 1 Publication1
Natural variantiVAR_0660891517C → R in DFNA12. 1 Publication1
Natural variantiVAR_0575011584S → T.Corresponds to variant rs34963131dbSNPEnsembl.1
Natural variantiVAR_0189711619C → S in DFNA12. 1 PublicationCorresponds to variant rs28939691dbSNPEnsembl.1
Natural variantiVAR_0189721724S → N.1 PublicationCorresponds to variant rs526433dbSNPEnsembl.1
Natural variantiVAR_0660901791P → R in DFNA12. 1 PublicationCorresponds to variant rs754213928dbSNPEnsembl.1
Natural variantiVAR_0189731820L → F in DFNA12; prelingual and stable deafness. 1 PublicationCorresponds to variant rs281865415dbSNPEnsembl.1
Natural variantiVAR_0189741824G → D in DFNA12; prelingual and stable deafness. 1 PublicationCorresponds to variant rs267607107dbSNPEnsembl.1
Natural variantiVAR_0189751837C → G in DFNA12; postlingual and progressive. 2 PublicationsCorresponds to variant rs121909061dbSNPEnsembl.1
Natural variantiVAR_0660911837C → R in DFNA12. 1 PublicationCorresponds to variant rs121909061dbSNPEnsembl.1
Natural variantiVAR_0660921866T → M in DFNA12. 2 PublicationsCorresponds to variant rs140236996dbSNPEnsembl.1
Natural variantiVAR_0660931867H → R in DFNA12. 1 Publication1
Natural variantiVAR_0189761870Y → C in DFNA12; prelingual and stable deafness. 1 PublicationCorresponds to variant rs28939690dbSNPEnsembl.1
Natural variantiVAR_0599651878S → R.Corresponds to variant rs202045605dbSNPEnsembl.1
Natural variantiVAR_0660941890R → C in DFNA12. 2 PublicationsCorresponds to variant rs121909063dbSNPEnsembl.1
Natural variantiVAR_0660951898C → R in DFNA12. 1 Publication1
Natural variantiVAR_0660961947R → C in DFNA12. 1 Publication1
Natural variantiVAR_0660972009I → T in DFNA12. 1 Publication1
Natural variantiVAR_0189772021R → H in DFNA12; prelingual and stable deafness. 1 PublicationCorresponds to variant rs121909062dbSNPEnsembl.1
Natural variantiVAR_0189782100S → T.1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF055136
, AF055114, AF055115, AF055116, AF055117, AF055118, AF055119, AF055120, AF055121, AF055122, AF055123, AF055124, AF055125, AF055126, AF055127, AF055128, AF055129, AF055130, AF055131, AF055132, AF055133, AF055134, AF055135 Genomic DNA. Translation: AAC26019.1.
AP000646 Genomic DNA. No translation available.
AP000826 Genomic DNA. No translation available.
CCDSiCCDS8434.1.
RefSeqiNP_005413.2. NM_005422.2.
UniGeneiHs.248162.

Genome annotation databases

EnsembliENST00000264037; ENSP00000264037; ENSG00000109927.
ENST00000392793; ENSP00000376543; ENSG00000109927.
GeneIDi7007.
KEGGihsa:7007.
UCSCiuc010rzo.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF055136
, AF055114, AF055115, AF055116, AF055117, AF055118, AF055119, AF055120, AF055121, AF055122, AF055123, AF055124, AF055125, AF055126, AF055127, AF055128, AF055129, AF055130, AF055131, AF055132, AF055133, AF055134, AF055135 Genomic DNA. Translation: AAC26019.1.
AP000646 Genomic DNA. No translation available.
AP000826 Genomic DNA. No translation available.
CCDSiCCDS8434.1.
RefSeqiNP_005413.2. NM_005422.2.
UniGeneiHs.248162.

3D structure databases

ProteinModelPortaliO75443.
SMRiO75443.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000264037.

PTM databases

iPTMnetiO75443.
PhosphoSitePlusiO75443.

Polymorphism and mutation databases

BioMutaiTECTA.

Proteomic databases

PaxDbiO75443.
PeptideAtlasiO75443.
PRIDEiO75443.

Protocols and materials databases

DNASUi7007.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264037; ENSP00000264037; ENSG00000109927.
ENST00000392793; ENSP00000376543; ENSG00000109927.
GeneIDi7007.
KEGGihsa:7007.
UCSCiuc010rzo.2. human.

Organism-specific databases

CTDi7007.
DisGeNETi7007.
GeneCardsiTECTA.
GeneReviewsiTECTA.
HGNCiHGNC:11720. TECTA.
HPAiHPA018870.
MalaCardsiTECTA.
MIMi601543. phenotype.
602574. gene.
603629. phenotype.
neXtProtiNX_O75443.
OpenTargetsiENSG00000109927.
Orphaneti90635. Autosomal dominant non-syndromic sensorineural deafness type DFNA.
90636. Autosomal recessive non-syndromic sensorineural deafness type DFNB.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1216. Eukaryota.
KOG4291. Eukaryota.
ENOG410YR2E. LUCA.
GeneTreeiENSGT00760000118896.
HOGENOMiHOG000168220.
HOVERGENiHBG079244.
InParanoidiO75443.
KOiK18273.
OMAiYSCKINC.
OrthoDBiEOG091G002A.
PhylomeDBiO75443.
TreeFamiTF300299.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000109927-MONOMER.

Miscellaneous databases

GeneWikiiTECTA.
GenomeRNAii7007.
PROiO75443.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000109927.
CleanExiHS_TECTA.
GenevisibleiO75443. HS.

Family and domain databases

InterProiIPR000742. EGF-like_dom.
IPR003886. NIDO_dom.
IPR033026. TECTA.
IPR002919. TIL_dom.
IPR025615. TILa_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001007. VWF_dom.
IPR001846. VWF_type-D.
IPR001507. ZP_dom.
IPR017977. ZP_dom_CS.
[Graphical view]
PANTHERiPTHR11339:SF235. PTHR11339:SF235. 2 hits.
PfamiPF08742. C8. 4 hits.
PF06119. NIDO. 1 hit.
PF01826. TIL. 3 hits.
PF12714. TILa. 2 hits.
PF00094. VWD. 4 hits.
PF00100. Zona_pellucida. 1 hit.
[Graphical view]
SMARTiSM00832. C8. 4 hits.
SM00181. EGF. 3 hits.
SM00539. NIDO. 1 hit.
SM00215. VWC_out. 3 hits.
SM00216. VWD. 4 hits.
SM00241. ZP. 1 hit.
[Graphical view]
SUPFAMiSSF57567. SSF57567. 3 hits.
PROSITEiPS51220. NIDO. 1 hit.
PS51233. VWFD. 4 hits.
PS00682. ZP_1. 1 hit.
PS51034. ZP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTECTA_HUMAN
AccessioniPrimary (citable) accession number: O75443
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: November 30, 2010
Last modified: November 2, 2016
This is version 147 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.