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O75443 (TECTA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 126. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alpha-tectorin
Gene names
Name:TECTA
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length2155 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

One of the major non-collagenous components of the tectorial membrane By similarity. The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals.

Subunit structure

May form homomeric filament after self-association or heteromeric filament after association with beta-tectorin. Interacts with CEACAM16. Ref.3

Subcellular location

Cell membrane; Lipid-anchorGPI-anchor; Extracellular side Probable. Secretedextracellular spaceextracellular matrix. Note: Found in the non-collagenous matrix of the tectorial membrane By similarity.

Domain

Zona pellucida domain may enable to form filaments.

Post-translational modification

The presence of a hydrophobic C-terminus preceded by a potential cleavage site strongly suggests that tectorins are synthesized as glycosylphosphatidylinositol-linked, membrane-bound precursors. Tectorins are targeted to the apical surface of the inner ear epithelia by the lipid and proteolytically released into the extracellular compartment.

Involvement in disease

Deafness, autosomal dominant, 12 (DFNA12) [MIM:601543]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.1 Ref.4 Ref.5 Ref.8 Ref.10 Ref.11 Ref.13 Ref.14 Ref.15

Deafness, autosomal recessive, 21 (DFNB21) [MIM:603629]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.6 Ref.9

Sequence similarities

Contains 1 NIDO domain.

Contains 3 TIL (trypsin inhibitory-like) domains.

Contains 1 VWFC domain.

Contains 4 VWFD domains.

Contains 1 ZP domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 20912069Alpha-tectorin
PRO_0000041735
Propeptide2092 – 215564Removed in mature form Potential
PRO_0000041736

Regions

Domain98 – 252155NIDO
Domain260 – 31455VWFC
Domain321 – 540220VWFD 1
Domain597 – 65054TIL 1
Domain712 – 929218VWFD 2
Domain984 – 103653TIL 2
Domain1099 – 1317219VWFD 3
Domain1372 – 142554TIL 3
Domain1486 – 1694209VWFD 4
Domain1805 – 2059255ZP

Amino acid modifications

Lipidation20911GPI-anchor amidated asparagine Potential
Glycosylation341N-linked (GlcNAc...) Potential
Glycosylation1871N-linked (GlcNAc...) Potential
Glycosylation2151N-linked (GlcNAc...) Potential
Glycosylation2781N-linked (GlcNAc...) Potential
Glycosylation4551N-linked (GlcNAc...) Potential
Glycosylation5061N-linked (GlcNAc...) Potential
Glycosylation5281N-linked (GlcNAc...) Potential
Glycosylation5601N-linked (GlcNAc...) Potential
Glycosylation6701N-linked (GlcNAc...) Potential
Glycosylation6871N-linked (GlcNAc...) Potential
Glycosylation8131N-linked (GlcNAc...) Potential
Glycosylation8431N-linked (GlcNAc...) Potential
Glycosylation8551N-linked (GlcNAc...) Potential
Glycosylation8981N-linked (GlcNAc...) Potential
Glycosylation9201N-linked (GlcNAc...) Potential
Glycosylation9311N-linked (GlcNAc...) Potential
Glycosylation9491N-linked (GlcNAc...) Potential
Glycosylation10481N-linked (GlcNAc...) Potential
Glycosylation12351N-linked (GlcNAc...) Potential
Glycosylation13641N-linked (GlcNAc...) Potential
Glycosylation15381N-linked (GlcNAc...) Potential
Glycosylation15651N-linked (GlcNAc...) Potential
Glycosylation17561N-linked (GlcNAc...) Potential
Glycosylation17721N-linked (GlcNAc...) Potential
Glycosylation17941N-linked (GlcNAc...) Potential
Glycosylation18511N-linked (GlcNAc...) Potential
Glycosylation18641N-linked (GlcNAc...) Potential
Glycosylation18801N-linked (GlcNAc...) Potential
Glycosylation19201N-linked (GlcNAc...) Potential
Glycosylation19391N-linked (GlcNAc...) Potential
Disulfide bond1980 ↔ 2040 By similarity

Natural variations

Natural variant191Q → R.
Corresponds to variant rs35507522 [ dbSNP | Ensembl ].
VAR_057500
Natural variant1971D → N in DFNA12. Ref.15
VAR_066076
Natural variant2111F → S in DFNA12. Ref.15
VAR_066077
Natural variant2841R → H in a breast cancer sample; somatic mutation. Ref.12
VAR_036423
Natural variant3171V → E in DFNA12. Ref.14
VAR_066078
Natural variant3621S → C in DFNA12. Ref.15
VAR_066079
Natural variant3711R → G. Ref.1 Ref.5
Corresponds to variant rs612969 [ dbSNP | Ensembl ].
VAR_018968
Natural variant4651N → K in DFNA12. Ref.15
VAR_066080
Natural variant5621T → M in DFNA12. Ref.15
VAR_066081
Natural variant7711I → N in a breast cancer sample; somatic mutation. Ref.12
VAR_036424
Natural variant8131N → T in a breast cancer sample; somatic mutation. Ref.12
VAR_036425
Natural variant8151T → M in DFNA12. Ref.15
VAR_066082
Natural variant8861N → S in DFNA12. Ref.15
VAR_066083
Natural variant9321V → A. Ref.1 Ref.5
Corresponds to variant rs520805 [ dbSNP | Ensembl ].
VAR_018969
Natural variant10361C → Y in DFNA12. Ref.15
VAR_066084
Natural variant10571C → S in DFNA12; progressive deafness with late onset. Ref.5
VAR_018970
Natural variant10981A → V in DFNA12. Ref.15
VAR_066085
Natural variant11361D → H in DFNA12. Ref.15
Corresponds to variant rs147890616 [ dbSNP | Ensembl ].
VAR_066086
Natural variant12481P → L in DFNA12. Ref.15
Corresponds to variant rs138768918 [ dbSNP | Ensembl ].
VAR_066087
Natural variant15091C → G in DFNA12. Ref.10
VAR_066088
Natural variant15171C → R in DFNA12. Ref.15
VAR_066089
Natural variant15841S → T.
Corresponds to variant rs34963131 [ dbSNP | Ensembl ].
VAR_057501
Natural variant16191C → S in DFNA12. Ref.4
Corresponds to variant rs28939691 [ dbSNP | Ensembl ].
VAR_018971
Natural variant17241S → N. Ref.1
Corresponds to variant rs526433 [ dbSNP | Ensembl ].
VAR_018972
Natural variant17911P → R in DFNA12. Ref.15
VAR_066090
Natural variant18201L → F in DFNA12; prelingual and stable deafness. Ref.1
VAR_018973
Natural variant18241G → D in DFNA12; prelingual and stable deafness. Ref.1
VAR_018974
Natural variant18371C → G in DFNA12; postlingual and progressive. Ref.7 Ref.15
VAR_018975
Natural variant18371C → R in DFNA12. Ref.13
VAR_066091
Natural variant18661T → M in DFNA12. Ref.14 Ref.15
VAR_066092
Natural variant18671H → R in DFNA12. Ref.15
VAR_066093
Natural variant18701Y → C in DFNA12; prelingual and stable deafness. Ref.1
Corresponds to variant rs28939690 [ dbSNP | Ensembl ].
VAR_018976
Natural variant18781S → R.
Corresponds to variant rs2155369 [ dbSNP | Ensembl ].
VAR_059965
Natural variant18901R → C in DFNA12. Ref.11 Ref.15
VAR_066094
Natural variant18981C → R in DFNA12. Ref.15
VAR_066095
Natural variant19471R → C in DFNA12. Ref.15
VAR_066096
Natural variant20091I → T in DFNA12. Ref.15
VAR_066097
Natural variant20211R → H in DFNA12; prelingual and stable deafness. Ref.8
VAR_018977
Natural variant21001S → T. Ref.5
VAR_018978

Sequences

Sequence LengthMass (Da)Tools
O75443 [UniParc].

Last modified November 30, 2010. Version 3.
Checksum: A7CB1CD9E7C594C3

FASTA2,155239,527
        10         20         30         40         50         60 
MNYSSFLRIW VSFIFALVQH QAQPRELMYP FWQNDTKTPK VDDGSSSEIK LAIPVFFFGV 

        70         80         90        100        110        120 
PYRTVYVNNN GVVSFNVLVS QFTPESFPLT DGRAFVAPFW ADVHNGIRGE IYYRETMEPA 

       130        140        150        160        170        180 
ILKRATKDIR KYFKDMATFS ATWVFIVTWE EVTFYGGSST TPVNTFQAVL VSDGSYTFTL 

       190        200        210        220        230        240 
FNYYEINWTT GTASGGDPLT GLGGVMAQAG FNGGNLTNFF SLPGSRTPEI VNIQETTNVN 

       250        260        270        280        290        300 
VPGRWAFKVD GKEIDPANGC TSRGQFLRRG EVFWDDLNCT VKCRCLDFNN EIYCQEASCS 

       310        320        330        340        350        360 
PYEVCEPKGK FFYCSAVETS TCVVFGEPHY HTFDGFLFHF QGSCAYLLAR QCLQTSSLPF 

       370        380        390        400        410        420 
FSVEAKNEHR RGSAVSWVKE LSVEVNGYKI LIPKGSYGRV KVNDLVTSLP VTLDLGTVKI 

       430        440        450        460        470        480 
YQSGISTAVE TDFGLLVTFD GQHYASISVP GSYINSTCGL CGNYNKNPLD DFLRPDGRPA 

       490        500        510        520        530        540 
MSVLDLGESW RVYHADWKCD SGCVDNCTQC DAATEALYFG SDYCGFLNKT DGPLWECGTV 

       550        560        570        580        590        600 
VDPTAFVHSC VYDLCSVRDN GTLLCQAIQA YALVCQALGI PIGDWRTQTG CVSTVQCPSF 

       610        620        630        640        650        660 
SHYSVCTSSC PDTCSDLTAS RNCATPCTEG CECNQGFVLS TSQCVPLHKC GCDFDGHYYT 

       670        680        690        700        710        720 
MGEFFWATAN CTVQCLCEEG GDVYCFNKTC GSGEVCAVED GYQGCFPKRE TVCLLSQNQV 

       730        740        750        760        770        780 
LHTFDGASYA FPSEFSYTLL KTCPERPEYL EIDINKKKPD AGPAWLRGLR ILVADQEVKI 

       790        800        810        820        830        840 
GGIGASEVKL NGQEVELPFF HPSGKLEIYR NKNSTTVESK GVVTVQYSDI GLLYIRLSTT 

       850        860        870        880        890        900 
YFNCTGGLCG FYNANASDEF CLPNGKCTDN LAVFLESWTT FEEICNGECG DLLKACNNDS 

       910        920        930        940        950        960 
ELLKFYRSRS RCGIINDPSN SSFLECHGVV NVTAYYRTCL FRLCQSGGNE SELCDSVARY 

       970        980        990       1000       1010       1020 
ASACKNADVE VGPWRTYDFC PLECPENSHF EECITCTETC ETLTLGPICV DSCSEGCQCD 

      1030       1040       1050       1060       1070       1080 
EGYALLGSQC VTRSECGCNF EGHQLATNET FWVDLDCQIF CYCSGTDNRV HCETIPCKDD 

      1090       1100       1110       1120       1130       1140 
EYCMEEGGLY YCQARTDASC IVSGYGHYLT FDGFPFDFQT SCPLILCTTG SRPSSDSFPK 

      1150       1160       1170       1180       1190       1200 
FVVTAKNEDR DPSLALWVKQ VDVTVFGYSI VIHRAYKHTV LVNSERLYLP LKLGQGKINI 

      1210       1220       1230       1240       1250       1260 
FSFGFHVVVE TDFGLKVVYD WKTFLSITVP RSMQNSTYGL CGRYNGNPDD DLEMPMGLLA 

      1270       1280       1290       1300       1310       1320 
SSVNEFGQSW VKRDTFCQVG CGDRCPSCAK VEGFSKVQQL CSLIPNQNAA FSKCHSKVNP 

      1330       1340       1350       1360       1370       1380 
TFFYKNCLFD SCIDGGAVQT ACSWLQNYAS TCQTQGITVT GWRNYTSCTV TCPPNSHYES 

      1390       1400       1410       1420       1430       1440 
CVSVCQPRCA AIRLKSDCSH YCVEGCHCDA GYVLNGKSCI LPHSCGCYSD GKYYEPKQLF 

      1450       1460       1470       1480       1490       1500 
WNSDCTRRCR CFRRNVIQCD PRQCKSDEEC ALRNGVRGCF STKTSYCLAA GGGVFRTFDG 

      1510       1520       1530       1540       1550       1560 
AFLRFPANCA FVLSTICQKL PDISFQLIIN FDKWSAPNLT IISPVYFYIN EEQILINDRN 

      1570       1580       1590       1600       1610       1620 
TVKVNGTQVN VPFITGLATK IYSSEGFLVI DTSPDIQIYY NGFNVIKISI SERLQNKVCG 

      1630       1640       1650       1660       1670       1680 
LCGNFNGDLT DDYVTLRGKP VVSSVVLAQS WKTNGMQKRP LAPSCNELQF SQYAAMCDNV 

      1690       1700       1710       1720       1730       1740 
HIQKMQGDGY CLKLTDMKGF FQPCYGLLDP LPFYESCYLD GCYSHKKFQL CGSLAAYGEA 

      1750       1760       1770       1780       1790       1800 
CRSFGILSTE WIEKENCSGV VEDPCVGADC PNRTCELGNG RELCGCIEPP PYGNNSHDII 

      1810       1820       1830       1840       1850       1860 
DAEVTCKAAQ MEVSISKCKL FQLGFEREGV RINDRQCTGI EGEDFISFQI NNTKGNCGNI 

      1870       1880       1890       1900       1910       1920 
VQSNGTHIMY KNTLWIESAN NTGNIITRDR TINVEFSCAY ELDIKISLDS VVKPMLSVIN 

      1930       1940       1950       1960       1970       1980 
LTVPTQEGSF ITKMALYKNA SYKHPYRQGE VVLTTRDVLY VGVFVVGADA THLILTLNKC 

      1990       2000       2010       2020       2030       2040 
YATPTRDSND KLRYFIIEGG CQNLKDNTIG IEENAVSLTC RFHVTVFKFI GDYDEVHLHC 

      2050       2060       2070       2080       2090       2100 
AVSLCDSEKY SCKITCPHNS RIATDYTKEP KEQIISVGPI RRKRLDWCED NGGCEQICTS 

      2110       2120       2130       2140       2150 
RVDGPLCSCV TGTLQEDGKS CRASNSSMEL QVWTLLLIMI QISLWHFVYK SGTTS 

« Hide

References

« Hide 'large scale' references
[1]"Mutations in the human alpha-tectorin gene cause autosomal dominant non-syndromic hearing impairment."
Verhoeven K., Van Laer L., Kirschhofer K., Legan P.K., Hughes D.C., Schatteman I., Verstreken M., Van Hauwe P., Coucke P., Chen A., Smith R.J.H., Somers T., Offeciers F.E., Van de Heyning P., Richardson G.P., Wachtler F., Kimberling W.J., Willems P.J., Govaerts P.J., Van Camp G.
Nat. Genet. 19:60-62(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS DFNA12 PHE-1820; ASP-1824 AND CYS-1870, VARIANTS GLY-371; ALA-932 AND ASN-1724.
[2]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Carcinoembryonic antigen-related cell adhesion molecule 16 interacts with alpha-tectorin and is mutated in autosomal dominant hearing loss (DFNA4)."
Zheng J., Miller K.K., Yang T., Hildebrand M.S., Shearer A.E., DeLuca A.P., Scheetz T.E., Drummond J., Scherer S.E., Legan P.K., Goodyear R.J., Richardson G.P., Cheatham M.A., Smith R.J., Dallos P.
Proc. Natl. Acad. Sci. U.S.A. 108:4218-4223(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH CEACAM16.
[4]"Mutation in the zonadhesin-like domain of alpha-tectorin associated with autosomal dominant non-syndromic hearing loss."
Alloisio N., Morle L., Bozon M., Godet J., Verhoeven K., Van Camp G., Plauchu H., Muller P., Collet L., Lina-Granade G.
Eur. J. Hum. Genet. 7:255-258(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT DFNA12 SER-1619.
[5]"Alpha-tectorin involvement in hearing disabilities: one gene -- two phenotypes."
Balciuniene J., Dahl N., Jalonen P., Verhoeven K., Van Camp G., Borg E., Pettersson U., Jazin E.E.
Hum. Genet. 105:211-216(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT DFNA12 SER-1057, VARIANTS GLY-371; ALA-932 AND THR-2100.
[6]"An alpha-tectorin gene defect causes a newly identified autosomal recessive form of sensorineural pre-lingual non-syndromic deafness, DFNB21."
Mustapha M., Weil D., Chardenoux S., Elias S., El-Zir E., Beckmann J.S., Loiselet J., Petit C.
Hum. Mol. Genet. 8:409-412(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN DFNB21.
[7]"A cysteine substitution in the zona pellucida domain of alpha-tectorin results in autosomal dominant, postlingual, progressive, mid frequency hearing loss in a Spanish family."
Moreno-Pelayo M.A., del Castillo I., Villamar M., Romero L., Hernandez-Calvin F.J., Herraiz C., Barbera R., Navas C., Moreno F.
J. Med. Genet. 38:E13-E13(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT GLY-1837.
[8]"Association of clinical features with mutation of TECTA in a family with autosomal dominant hearing loss."
Iwasaki S., Harada D., Usami S., Nagura M., Takeshita T., Hoshino T.
Arch. Otolaryngol. Head Neck Surg. 128:913-917(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT DFNA12 HIS-2021.
[9]"Distinctive audiometric profile associated with DFNB21 alleles of TECTA."
Naz S., Alasti F., Mowjoodi A., Riazuddin S., Sanati M.H., Friedman T.B., Griffith A.J., Wilcox E.R., Riazuddin S.
J. Med. Genet. 40:360-363(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN DFNB21.
[10]"A genotype-phenotype correlation with gender-effect for hearing impairment caused by TECTA mutations."
Pfister M., Thiele H., Van Camp G., Fransen E., Apaydin F., Aydin O., Leistenschneider P., Devoto M., Zenner H.P., Blin N., Nurnberg P., Ozkarakas H., Kupka S.
Cell. Physiol. Biochem. 14:369-376(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT DFNA12 GLY-1509.
[11]"A novel TECTA mutation in a Dutch DFNA8/12 family confirms genotype-phenotype correlation."
Plantinga R.F., de Brouwer A.P., Huygen P.L., Kunst H.P., Kremer H., Cremers C.W.
J. Assoc. Res. Otolaryngol. 7:173-181(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT DFNA12 CYS-1890.
[12]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS [LARGE SCALE ANALYSIS] HIS-284; ASN-771 AND THR-813.
[13]"Audioprofiling identifies TECTA and GJB2-related deafness segregating in a single extended pedigree."
Meyer N.C., Nishimura C.J., McMordie S., Smith R.J.
Clin. Genet. 72:130-137(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT DFNA12 ARG-1837.
[14]"Two novel missense mutations in the TECTA gene in Korean families with autosomal dominant nonsyndromic hearing loss."
Sagong B., Park R., Kim Y.H., Lee K.Y., Baek J.I., Cho H.J., Cho I.J., Kim U.K., Lee S.H.
Ann. Clin. Lab. Sci. 40:380-385(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS DFNA12 GLU-317 AND MET-1866.
[15]"DFNA8/12 caused by TECTA mutations is the most identified subtype of nonsyndromic autosomal dominant hearing loss."
Hildebrand M.S., Morin M., Meyer N.C., Mayo F., Modamio-Hoybjor S., Mencia A., Olavarrieta L., Morales-Angulo C., Nishimura C.J., Workman H., DeLuca A.P., del Castillo I., Taylor K.R., Tompkins B., Goodman C.W., Schrauwen I., Wesemael M.V., Lachlan K. expand/collapse author list , Shearer A.E., Braun T.A., Huygen P.L., Kremer H., Van Camp G., Moreno F., Casavant T.L., Smith R.J., Moreno-Pelayo M.A.
Hum. Mutat. 32:825-834(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS DFNA12 ASN-197; SER-211; CYS-362; LYS-465; MET-562; MET-815; SER-886; TYR-1036; VAL-1098; HIS-1136; LEU-1248; ARG-1517; ARG-1791; GLY-1837; MET-1866; ARG-1867; CYS-1890; ARG-1898; CYS-1947 AND THR-2009.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF055136 expand/collapse EMBL AC list , AF055114, AF055115, AF055116, AF055117, AF055118, AF055119, AF055120, AF055121, AF055122, AF055123, AF055124, AF055125, AF055126, AF055127, AF055128, AF055129, AF055130, AF055131, AF055132, AF055133, AF055134, AF055135 Genomic DNA. Translation: AAC26019.1.
AP000646 Genomic DNA. No translation available.
AP000826 Genomic DNA. No translation available.
RefSeqNP_005413.2. NM_005422.2.
UniGeneHs.248162.

3D structure databases

ProteinModelPortalO75443.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000264037.

PTM databases

PhosphoSiteO75443.

Proteomic databases

PaxDbO75443.
PRIDEO75443.

Protocols and materials databases

DNASU7007.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000264037; ENSP00000264037; ENSG00000109927.
ENST00000392793; ENSP00000376543; ENSG00000109927.
GeneID7007.
KEGGhsa:7007.
UCSCuc010rzo.2. human.

Organism-specific databases

CTD7007.
GeneCardsGC11P121007.
HGNCHGNC:11720. TECTA.
HPAHPA018870.
MIM601543. phenotype.
602574. gene.
603629. phenotype.
neXtProtNX_O75443.
Orphanet90635. Autosomal dominant nonsyndromic sensorineural deafness type DFNA.
90636. Autosomal recessive nonsyndromic sensorineural deafness type DFNB.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG317991.
HOGENOMHOG000168220.
HOVERGENHBG079244.
InParanoidO75443.
OMAAQPRELM.
OrthoDBEOG7SJD3N.
PhylomeDBO75443.
TreeFamTF300299.

Gene expression databases

BgeeO75443.
CleanExHS_TECTA.
GenevestigatorO75443.

Family and domain databases

InterProIPR000742. EG-like_dom.
IPR003886. Nidogen_extracell_dom.
IPR002919. TIL_dom.
IPR025615. TILa_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR006552. VWC_out.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
IPR001507. ZP_dom.
IPR017977. ZP_dom_CS.
[Graphical view]
PfamPF08742. C8. 4 hits.
PF06119. NIDO. 1 hit.
PF01826. TIL. 3 hits.
PF12714. TILa. 2 hits.
PF00094. VWD. 4 hits.
PF00100. Zona_pellucida. 1 hit.
[Graphical view]
SMARTSM00832. C8. 4 hits.
SM00181. EGF. 1 hit.
SM00539. NIDO. 1 hit.
SM00214. VWC. 1 hit.
SM00215. VWC_out. 1 hit.
SM00216. VWD. 4 hits.
SM00241. ZP. 1 hit.
[Graphical view]
SUPFAMSSF57567. SSF57567. 3 hits.
PROSITEPS51220. NIDO. 1 hit.
PS51233. VWFD. 4 hits.
PS00682. ZP_1. 1 hit.
PS51034. ZP_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiTECTA.
GenomeRNAi7007.
NextBio27370.
PROO75443.
SOURCESearch...

Entry information

Entry nameTECTA_HUMAN
AccessionPrimary (citable) accession number: O75443
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: November 30, 2010
Last modified: March 19, 2014
This is version 126 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM