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O75439

- MPPB_HUMAN

UniProt

O75439 - MPPB_HUMAN

Protein

Mitochondrial-processing peptidase subunit beta

Gene

PMPCB

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 2 (11 Apr 2003)
      Previous versions | rss
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    Functioni

    Cleaves presequences (transit peptides) from mitochondrial protein precursors.By similarity

    Catalytic activityi

    Release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi101 – 1011ZincPROSITE-ProRule annotation
    Active sitei104 – 1041Proton acceptorPROSITE-ProRule annotation
    Metal bindingi105 – 1051ZincPROSITE-ProRule annotation
    Metal bindingi181 – 1811ZincPROSITE-ProRule annotation

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. metalloendopeptidase activity Source: InterPro

    GO - Biological processi

    1. cellular protein metabolic process Source: Reactome
    2. protein targeting to mitochondrion Source: Reactome

    Keywords - Molecular functioni

    Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_118595. Mitochondrial protein import.
    SignaLinkiO75439.

    Protein family/group databases

    MEROPSiM16.003.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial-processing peptidase subunit beta (EC:3.4.24.64)
    Alternative name(s):
    Beta-MPP
    P-52
    Gene namesi
    Name:PMPCB
    Synonyms:MPPB
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:9119. PMPCB.

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: Ensembl
    2. mitochondrial matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33445.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 4545Mitochondrion1 PublicationAdd
    BLAST
    Chaini46 – 489444Mitochondrial-processing peptidase subunit betaPRO_0000026777Add
    BLAST

    Proteomic databases

    MaxQBiO75439.
    PaxDbiO75439.
    PRIDEiO75439.

    PTM databases

    PhosphoSiteiO75439.

    Expressioni

    Gene expression databases

    ArrayExpressiO75439.
    BgeeiO75439.
    CleanExiHS_PMPCB.
    GenevestigatoriO75439.

    Organism-specific databases

    HPAiHPA040674.

    Interactioni

    Subunit structurei

    Heterodimer of alpha and beta subunits.By similarity

    Protein-protein interaction databases

    BioGridi114889. 10 interactions.
    IntActiO75439. 2 interactions.
    MINTiMINT-1401899.
    STRINGi9606.ENSP00000249269.

    Structurei

    3D structure databases

    ProteinModelPortaliO75439.
    SMRiO75439. Positions 50-486.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M16 family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0612.
    HOGENOMiHOG000242450.
    HOVERGENiHBG006393.
    InParanoidiO75439.
    KOiK17732.
    OrthoDBiEOG74R1QJ.
    PhylomeDBiO75439.
    TreeFamiTF105032.

    Family and domain databases

    Gene3Di3.30.830.10. 2 hits.
    InterProiIPR011249. Metalloenz_LuxS/M16.
    IPR011237. Pept_M16_dom.
    IPR011765. Pept_M16_N.
    IPR001431. Pept_M16_Zn_BS.
    IPR007863. Peptidase_M16_C.
    [Graphical view]
    PfamiPF00675. Peptidase_M16. 1 hit.
    PF05193. Peptidase_M16_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF63411. SSF63411. 2 hits.
    PROSITEiPS00143. INSULINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O75439-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAAAARVVL SSAARRRLWG FSESLLIRGA AGRSLYFGEN RLRSTQAATQ    50
    VVLNVPETRV TCLESGLRVA SEDSGLSTCT VGLWIDAGSR YENEKNNGTA 100
    HFLEHMAFKG TKKRSQLDLE LEIENMGAHL NAYTSREQTV YYAKAFSKDL 150
    PRAVEILADI IQNSTLGEAE IERERGVILR EMQEVETNLQ EVVFDYLHAT 200
    AYQNTALGRT ILGPTENIKS ISRKDLVDYI TTHYKGPRIV LAAAGGVSHD 250
    ELLDLAKFHF GDSLCTHKGE IPALPPCKFT GSEIRVRDDK MPLAHLAIAV 300
    EAVGWAHPDT ICLMVANTLI GNWDRSFGGG MNLSSKLAQL TCHGNLCHSF 350
    QSFNTSYTDT GLWGLYMVCE SSTVADMLHV VQKEWMRLCT SVTESEVARA 400
    RNLLKTNMLL QLDGSTPICE DIGRQMLCYN RRIPIPELEA RIDAVNAETI 450
    REVCTKYIYN RSPAIAAVGP IKQLPDFKQI RSNMCWLRD 489
    Length:489
    Mass (Da):54,366
    Last modified:April 11, 2003 - v2
    Checksum:i79250D016E60CFEE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti16 – 172RR → GG in AAC39915. (PubMed:9653160)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti396 – 3961E → D.
    Corresponds to variant rs3087615 [ dbSNP | Ensembl ].
    VAR_051572

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF054182 mRNA. Translation: AAC39915.1.
    AC004668 Genomic DNA. No translation available.
    CCDSiCCDS5730.1.
    RefSeqiNP_004270.2. NM_004279.2.
    UniGeneiHs.184211.

    Genome annotation databases

    EnsembliENST00000249269; ENSP00000249269; ENSG00000105819.
    GeneIDi9512.
    KEGGihsa:9512.
    UCSCiuc003vbl.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF054182 mRNA. Translation: AAC39915.1 .
    AC004668 Genomic DNA. No translation available.
    CCDSi CCDS5730.1.
    RefSeqi NP_004270.2. NM_004279.2.
    UniGenei Hs.184211.

    3D structure databases

    ProteinModelPortali O75439.
    SMRi O75439. Positions 50-486.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114889. 10 interactions.
    IntActi O75439. 2 interactions.
    MINTi MINT-1401899.
    STRINGi 9606.ENSP00000249269.

    Protein family/group databases

    MEROPSi M16.003.

    PTM databases

    PhosphoSitei O75439.

    Proteomic databases

    MaxQBi O75439.
    PaxDbi O75439.
    PRIDEi O75439.

    Protocols and materials databases

    DNASUi 9512.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000249269 ; ENSP00000249269 ; ENSG00000105819 .
    GeneIDi 9512.
    KEGGi hsa:9512.
    UCSCi uc003vbl.3. human.

    Organism-specific databases

    CTDi 9512.
    GeneCardsi GC07P102937.
    H-InvDB HIX0006969.
    HGNCi HGNC:9119. PMPCB.
    HPAi HPA040674.
    MIMi 603131. gene.
    neXtProti NX_O75439.
    PharmGKBi PA33445.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0612.
    HOGENOMi HOG000242450.
    HOVERGENi HBG006393.
    InParanoidi O75439.
    KOi K17732.
    OrthoDBi EOG74R1QJ.
    PhylomeDBi O75439.
    TreeFami TF105032.

    Enzyme and pathway databases

    Reactomei REACT_118595. Mitochondrial protein import.
    SignaLinki O75439.

    Miscellaneous databases

    ChiTaRSi PMPCB. human.
    GeneWikii PMPCB.
    GenomeRNAii 9512.
    NextBioi 35642.
    PROi O75439.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O75439.
    Bgeei O75439.
    CleanExi HS_PMPCB.
    Genevestigatori O75439.

    Family and domain databases

    Gene3Di 3.30.830.10. 2 hits.
    InterProi IPR011249. Metalloenz_LuxS/M16.
    IPR011237. Pept_M16_dom.
    IPR011765. Pept_M16_N.
    IPR001431. Pept_M16_Zn_BS.
    IPR007863. Peptidase_M16_C.
    [Graphical view ]
    Pfami PF00675. Peptidase_M16. 1 hit.
    PF05193. Peptidase_M16_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF63411. SSF63411. 2 hits.
    PROSITEi PS00143. INSULINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning."
      Mao M., Fu G., Wu J.-S., Zhang Q.-H., Zhou J., Kan L.-X., Huang Q.-H., He K.-L., Gu B.-W., Han Z.-G., Shen Y., Gu J., Yu Y.-P., Xu S.-H., Wang Y.-X., Chen S.-J., Chen Z.
      Proc. Natl. Acad. Sci. U.S.A. 95:8175-8180(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Umbilical cord blood.
    2. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini."
      Xu G., Shin S.B., Jaffrey S.R.
      Proc. Natl. Acad. Sci. U.S.A. 106:19310-19315(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE [LARGE SCALE ANALYSIS] OF 46-60.
      Tissue: Leukemic T-cell.
    4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiMPPB_HUMAN
    AccessioniPrimary (citable) accession number: O75439
    Secondary accession number(s): O60416, Q96FV4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: April 11, 2003
    Last modified: October 1, 2014
    This is version 130 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Peptidase families
      Classification of peptidase families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3