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O75436

- VP26A_HUMAN

UniProt

O75436 - VP26A_HUMAN

Protein

Vacuolar protein sorting-associated protein 26A

Gene

VPS26A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 2 (25 Nov 2002)
      Previous versions | rss
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    Functioni

    Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA).2 Publications

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. protein transporter activity Source: UniProtKB

    GO - Biological processi

    1. retrograde transport, endosome to Golgi Source: UniProtKB

    Keywords - Biological processi

    Protein transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_163710. WNT ligand biogenesis and trafficking.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vacuolar protein sorting-associated protein 26A
    Alternative name(s):
    Vesicle protein sorting 26A
    Short name:
    hVPS26
    Gene namesi
    Name:VPS26A
    Synonyms:VPS26
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:12711. VPS26A.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: UniProtKB
    2. endosome Source: UniProtKB
    3. endosome membrane Source: UniProtKB-SubCell
    4. extracellular vesicular exosome Source: UniProt
    5. intracellular membrane-bounded organelle Source: HPA
    6. vesicle Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Endosome, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi235 – 2362IM → DD: Abolishes interaction with VPS35 and endosomal subcellular location. 1 Publication

    Organism-specific databases

    PharmGKBiPA37326.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 327327Vacuolar protein sorting-associated protein 26APRO_0000073007Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei315 – 3151Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiO75436.
    PaxDbiO75436.
    PeptideAtlasiO75436.
    PRIDEiO75436.

    PTM databases

    PhosphoSiteiO75436.

    Expressioni

    Inductioni

    Down-regulated in Alzheimer disease. No polymorphism or variant is however associated with Alzheimer disease for VPS26A.2 Publications

    Gene expression databases

    ArrayExpressiO75436.
    BgeeiO75436.
    CleanExiHS_VPS26A.
    GenevestigatoriO75436.

    Organism-specific databases

    HPAiCAB011602.
    HPA044581.

    Interactioni

    Subunit structurei

    Component of the retromer complex composed of VPS26 (VPS26A or VPS26B), VPS29, VPS35, SNX1 and SNX2. Interacts directly with VPS35. Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. Interacts with ECM29.5 Publications

    Protein-protein interaction databases

    BioGridi114930. 58 interactions.
    DIPiDIP-29075N.
    IntActiO75436. 2 interactions.
    MINTiMINT-5000831.
    STRINGi9606.ENSP00000263559.

    Structurei

    Secondary structure

    1
    327
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni7 – 115
    Beta strandi12 – 187
    Helixi21 – 233
    Beta strandi26 – 305
    Beta strandi36 – 427
    Beta strandi48 – 6013
    Beta strandi63 – 664
    Beta strandi68 – 7811
    Beta strandi85 – 9612
    Beta strandi98 – 1014
    Beta strandi105 – 1117
    Beta strandi124 – 13613
    Beta strandi139 – 1413
    Beta strandi143 – 1519
    Beta strandi164 – 1707
    Turni171 – 1733
    Beta strandi174 – 1818
    Beta strandi183 – 1864
    Beta strandi190 – 20011
    Beta strandi204 – 21815
    Helixi220 – 2223
    Beta strandi224 – 23411
    Beta strandi246 – 2527
    Turni253 – 2553
    Beta strandi261 – 2655
    Beta strandi268 – 28013
    Beta strandi285 – 29511

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2FAUX-ray2.10A1-327[»]
    ProteinModelPortaliO75436.
    SMRiO75436. Positions 6-299.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO75436.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the VPS26 family.Curated

    Phylogenomic databases

    eggNOGiNOG256244.
    HOGENOMiHOG000191799.
    HOVERGENiHBG082914.
    InParanoidiO75436.
    OMAiPVCEIDV.
    OrthoDBiEOG7NW699.
    PhylomeDBiO75436.
    TreeFamiTF300907.

    Family and domain databases

    InterProiIPR028934. Vps26-related.
    [Graphical view]
    PfamiPF03643. Vps26. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O75436-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSFLGGFFGP ICEIDIVLND GETRKMAEMK TEDGKVEKHY LFYDGESVSG    50
    KVNLAFKQPG KRLEHQGIRI EFVGQIELFN DKSNTHEFVN LVKELALPGE 100
    LTQSRSYDFE FMQVEKPYES YIGANVRLRY FLKVTIVRRL TDLVKEYDLI 150
    VHQLATYPDV NNSIKMEVGI EDCLHIEFEY NKSKYHLKDV IVGKIYFLLV 200
    RIKIQHMELQ LIKKEITGIG PSTTTETETI AKYEIMDGAP VKGESIPIRL 250
    FLAGYDPTPT MRDVNKKFSV RYFLNLVLVD EEDRRYFKQQ EIILWRKAPE 300
    KLRKQRTNFH QRFESPESQA SAEQPEM 327
    Length:327
    Mass (Da):38,170
    Last modified:November 25, 2002 - v2
    Checksum:iBD3B2EAA6CFCBFA9
    GO
    Isoform 2 (identifier: O75436-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         243-327: GESIPIRLFL...SQASAEQPEM → GDNFMEKSS

    Note: No experimental confirmation available.Curated

    Show »
    Length:251
    Mass (Da):28,938
    Checksum:i1140DC4C2D80D257
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti75 – 751Q → R in BAB14351. (PubMed:14702039)Curated
    Sequence conflicti242 – 2421K → Q in BQ048905. (PubMed:15489334)Curated
    Sequence conflicti285 – 2862RY → SS in AAF89954. (PubMed:11102511)Curated
    Sequence conflicti285 – 2862RY → SS in AAC39912. (PubMed:9653160)Curated
    Isoform 2 (identifier: O75436-2)
    Sequence conflicti243 – 2431G → R in BQ048905. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei243 – 32785GESIP…EQPEM → GDNFMEKSS in isoform 2. 1 PublicationVSP_044910Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF175266 mRNA. Translation: AAF89954.1.
    AF054179 mRNA. Translation: AAC39912.1.
    AK022992 mRNA. Translation: BAB14351.1.
    AK315496 mRNA. Translation: BAG37880.1.
    AL596223, AL442635 Genomic DNA. Translation: CAH71501.1.
    AL442635, AL596223 Genomic DNA. Translation: CAH71779.1.
    CH471083 Genomic DNA. Translation: EAW54313.1.
    BC022505 mRNA. Translation: AAH22505.1.
    BQ048905 mRNA. No translation available.
    CCDSiCCDS41536.1. [O75436-2]
    CCDS7286.1. [O75436-1]
    RefSeqiNP_001030337.1. NM_001035260.1. [O75436-2]
    NP_004887.2. NM_004896.3. [O75436-1]
    UniGeneiHs.499925.

    Genome annotation databases

    EnsembliENST00000263559; ENSP00000263559; ENSG00000122958. [O75436-1]
    ENST00000373382; ENSP00000362480; ENSG00000122958. [O75436-1]
    ENST00000395098; ENSP00000378532; ENSG00000122958. [O75436-2]
    GeneIDi9559.
    KEGGihsa:9559.
    UCSCiuc001jpb.3. human. [O75436-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF175266 mRNA. Translation: AAF89954.1 .
    AF054179 mRNA. Translation: AAC39912.1 .
    AK022992 mRNA. Translation: BAB14351.1 .
    AK315496 mRNA. Translation: BAG37880.1 .
    AL596223 , AL442635 Genomic DNA. Translation: CAH71501.1 .
    AL442635 , AL596223 Genomic DNA. Translation: CAH71779.1 .
    CH471083 Genomic DNA. Translation: EAW54313.1 .
    BC022505 mRNA. Translation: AAH22505.1 .
    BQ048905 mRNA. No translation available.
    CCDSi CCDS41536.1. [O75436-2 ]
    CCDS7286.1. [O75436-1 ]
    RefSeqi NP_001030337.1. NM_001035260.1. [O75436-2 ]
    NP_004887.2. NM_004896.3. [O75436-1 ]
    UniGenei Hs.499925.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2FAU X-ray 2.10 A 1-327 [» ]
    ProteinModelPortali O75436.
    SMRi O75436. Positions 6-299.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114930. 58 interactions.
    DIPi DIP-29075N.
    IntActi O75436. 2 interactions.
    MINTi MINT-5000831.
    STRINGi 9606.ENSP00000263559.

    PTM databases

    PhosphoSitei O75436.

    Proteomic databases

    MaxQBi O75436.
    PaxDbi O75436.
    PeptideAtlasi O75436.
    PRIDEi O75436.

    Protocols and materials databases

    DNASUi 9559.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000263559 ; ENSP00000263559 ; ENSG00000122958 . [O75436-1 ]
    ENST00000373382 ; ENSP00000362480 ; ENSG00000122958 . [O75436-1 ]
    ENST00000395098 ; ENSP00000378532 ; ENSG00000122958 . [O75436-2 ]
    GeneIDi 9559.
    KEGGi hsa:9559.
    UCSCi uc001jpb.3. human. [O75436-1 ]

    Organism-specific databases

    CTDi 9559.
    GeneCardsi GC10P070885.
    HGNCi HGNC:12711. VPS26A.
    HPAi CAB011602.
    HPA044581.
    MIMi 605506. gene.
    neXtProti NX_O75436.
    PharmGKBi PA37326.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG256244.
    HOGENOMi HOG000191799.
    HOVERGENi HBG082914.
    InParanoidi O75436.
    OMAi PVCEIDV.
    OrthoDBi EOG7NW699.
    PhylomeDBi O75436.
    TreeFami TF300907.

    Enzyme and pathway databases

    Reactomei REACT_163710. WNT ligand biogenesis and trafficking.

    Miscellaneous databases

    ChiTaRSi VPS26A. human.
    EvolutionaryTracei O75436.
    GeneWikii VPS26A.
    GenomeRNAii 9559.
    NextBioi 35853.
    PROi O75436.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O75436.
    Bgeei O75436.
    CleanExi HS_VPS26A.
    Genevestigatori O75436.

    Family and domain databases

    InterProi IPR028934. Vps26-related.
    [Graphical view ]
    Pfami PF03643. Vps26. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes."
      Renfrew Haft C., de la Luz Sierra M., Bafford R., Lesniak M.A., Barr V.A., Taylor S.I.
      Mol. Biol. Cell 11:4105-4116(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH VPS29; VPS35; SNX1 AND SNX2.
      Tissue: Colon.
    2. "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning."
      Mao M., Fu G., Wu J.-S., Zhang Q.-H., Zhou J., Kan L.-X., Huang Q.-H., He K.-L., Gu B.-W., Han Z.-G., Shen Y., Gu J., Yu Y.-P., Xu S.-H., Wang Y.-X., Chen S.-J., Chen Z.
      Proc. Natl. Acad. Sci. U.S.A. 95:8175-8180(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Umbilical cord blood.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Tongue.
    4. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-249 (ISOFORM 2).
      Tissue: Brain and Embryonic testis carcinoma.
    7. "Exportin 7 defines a novel general nuclear export pathway."
      Mingot J.-M., Bohnsack M.T., Jaekle U., Goerlich D.
      EMBO J. 23:3227-3236(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN A COMPLEX WITH XPO7; ARHGAP1; EIF4A1; VPS29; VPS35 AND SFN.
    8. "The mammalian retromer regulates transcytosis of the polymeric immunoglobulin receptor."
      Verges M., Luton F., Gruber C., Tiemann F., Reinders L.G., Huang L., Burlingame A.L., Haft C.R., Mostov K.E.
      Nat. Cell Biol. 6:763-769(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    9. "Model-guided microarray implicates the retromer complex in Alzheimer's disease."
      Small S.A., Kent K., Pierce A., Leung C., Kang M.S., Okada H., Honig L., Vonsattel J.-P., Kim T.-W.
      Ann. Neurol. 58:909-919(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    10. Cited for: SUBCELLULAR LOCATION, INTERACTION WITH VPS35.
    11. "An essential role for SNX1 in lysosomal sorting of protease-activated receptor-1: evidence for retromer-, Hrs-, and Tsg101-independent functions of sorting nexins."
      Gullapalli A., Wolfe B.L., Griffin C.T., Magnuson T., Trejo J.
      Mol. Biol. Cell 17:1228-1238(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    12. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
      Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. "No association of vacuolar protein sorting 26 polymorphisms with Alzheimer's disease."
      Riemenschneider M., Schoepfer-Wendels A., Friedrich P., Konta L., Laws S.M., Mueller J.C., Kurz A., Forstl H.
      Neurobiol. Aging 28:883-884(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    14. "A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components."
      Gorbea C., Pratt G., Ustrell V., Bell R., Sahasrabudhe S., Hughes R.E., Rechsteiner M.
      J. Biol. Chem. 285:31616-31633(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, INTERACTION WITH ECM29.
    15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-315, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    16. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    17. "The retromer subunit Vps26 has an arrestin fold and binds Vps35 through its C-terminal domain."
      Shi H., Rojas R., Bonifacino J.S., Hurley J.H.
      Nat. Struct. Mol. Biol. 13:540-548(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS), SUBCELLULAR LOCATION, INTERACTION WITH VPS35, MUTAGENESIS OF 236-ILE-MET-237.

    Entry informationi

    Entry nameiVP26A_HUMAN
    AccessioniPrimary (citable) accession number: O75436
    Secondary accession number(s): A8MZ56
    , B2RDD3, Q8TBH4, Q9H982
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: November 25, 2002
    Last modified: October 1, 2014
    This is version 127 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3