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Protein

Metaxin-2

Gene

MTX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in transport of proteins into the mitochondrion.1 Publication

GO - Biological processi

  • mitochondrial transport Source: ProtInc
  • protein targeting to mitochondrion Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000128654-MONOMER.
ReactomeiR-HSA-1268020. Mitochondrial protein import.

Names & Taxonomyi

Protein namesi
Recommended name:
Metaxin-2
Alternative name(s):
Mitochondrial outer membrane import complex protein 2
Gene namesi
Name:MTX2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:7506. MTX2.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial outer membrane Source: ProtInc
  • mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10651.
OpenTargetsiENSG00000128654.
PharmGKBiPA31308.

Polymorphism and mutation databases

BioMutaiMTX2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002209952 – 263Metaxin-2Add BLAST262

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiO75431.
MaxQBiO75431.
PaxDbiO75431.
PeptideAtlasiO75431.
PRIDEiO75431.
TopDownProteomicsiO75431-1. [O75431-1]

PTM databases

iPTMnetiO75431.
PhosphoSitePlusiO75431.
SwissPalmiO75431.

Expressioni

Gene expression databases

BgeeiENSG00000128654.
CleanExiHS_MTX2.
ExpressionAtlasiO75431. baseline and differential.
GenevisibleiO75431. HS.

Organism-specific databases

HPAiHPA031550.
HPA031551.
HPA031552.

Interactioni

Subunit structurei

Interacts with MTX1/metaxin-1. Associates with the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MINOS1/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and QIL1/MIC13. This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1, MTX2 and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CCDC155Q8N6L05EBI-7415268,EBI-749265
TADA2AO754783EBI-7415268,EBI-742268

Protein-protein interaction databases

BioGridi115894. 28 interactors.
IntActiO75431. 15 interactors.
MINTiMINT-3001232.
STRINGi9606.ENSP00000249442.

Structurei

3D structure databases

ProteinModelPortaliO75431.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the metaxin family.Curated

Phylogenomic databases

eggNOGiKOG3027. Eukaryota.
ENOG410XY7W. LUCA.
GeneTreeiENSGT00530000063166.
HOGENOMiHOG000231908.
HOVERGENiHBG003471.
InParanoidiO75431.
KOiK17776.
OMAiPWPENAA.
OrthoDBiEOG091G132X.
PhylomeDBiO75431.
TreeFamiTF313422.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR033468. Metaxin_GST.
IPR019564. Sam37/metaxin_N.
[Graphical view]
PfamiPF17171. GST_C_6. 1 hit.
PF10568. Tom37. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75431-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLVAEAFVS QIAAAEPWPE NATLYQQLKG EQILLSDNAA SLAVQAFLQM
60 70 80 90 100
CNLPIKVVCR ANAEYMSPSG KVPFIHVGNQ VVSELGPIVQ FVKAKGHSLS
110 120 130 140 150
DGLEEVQKAE MKAYMELVNN MLLTAELYLQ WCDEATVGEI THARYGSPYP
160 170 180 190 200
WPLNHILAYQ KQWEVKRKMK AIGWGKKTLD QVLEDVDQCC QALSQRLGTQ
210 220 230 240 250
PYFFNKQPTE LDALVFGHLY TILTTQLTND ELSEKVKNYS NLLAFCRRIE
260
QHYFEDRGKG RLS
Length:263
Mass (Da):29,763
Last modified:November 1, 1998 - v1
Checksum:i3A2EF476F1C78465
GO
Isoform 2 (identifier: O75431-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MSLVAEAFVSQIA → MYI

Show »
Length:253
Mass (Da):28,823
Checksum:iBEA40149AD239824
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0544681 – 13MSLVA…VSQIA → MYI in isoform 2. 2 PublicationsAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053551 mRNA. Translation: AAC25105.1.
AK289359 mRNA. Translation: BAF82048.1.
AK303564 mRNA. Translation: BAG64587.1.
AC016739 Genomic DNA. Translation: AAY14795.1.
AC073069 Genomic DNA. Translation: AAX93188.1.
CH471058 Genomic DNA. Translation: EAX11076.1.
CH471058 Genomic DNA. Translation: EAX11078.1.
BC017271 mRNA. Translation: AAH17271.1.
BC067831 mRNA. Translation: AAH67831.1.
BC088359 mRNA. Translation: AAH88359.1.
CCDSiCCDS2272.1. [O75431-1]
RefSeqiNP_001006636.1. NM_001006635.2. [O75431-2]
NP_001306026.1. NM_001319097.1.
NP_001306027.1. NM_001319098.1.
NP_006545.1. NM_006554.4. [O75431-1]
UniGeneiHs.470728.

Genome annotation databases

EnsembliENST00000249442; ENSP00000249442; ENSG00000128654. [O75431-1]
GeneIDi10651.
KEGGihsa:10651.
UCSCiuc002ukx.4. human. [O75431-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053551 mRNA. Translation: AAC25105.1.
AK289359 mRNA. Translation: BAF82048.1.
AK303564 mRNA. Translation: BAG64587.1.
AC016739 Genomic DNA. Translation: AAY14795.1.
AC073069 Genomic DNA. Translation: AAX93188.1.
CH471058 Genomic DNA. Translation: EAX11076.1.
CH471058 Genomic DNA. Translation: EAX11078.1.
BC017271 mRNA. Translation: AAH17271.1.
BC067831 mRNA. Translation: AAH67831.1.
BC088359 mRNA. Translation: AAH88359.1.
CCDSiCCDS2272.1. [O75431-1]
RefSeqiNP_001006636.1. NM_001006635.2. [O75431-2]
NP_001306026.1. NM_001319097.1.
NP_001306027.1. NM_001319098.1.
NP_006545.1. NM_006554.4. [O75431-1]
UniGeneiHs.470728.

3D structure databases

ProteinModelPortaliO75431.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115894. 28 interactors.
IntActiO75431. 15 interactors.
MINTiMINT-3001232.
STRINGi9606.ENSP00000249442.

PTM databases

iPTMnetiO75431.
PhosphoSitePlusiO75431.
SwissPalmiO75431.

Polymorphism and mutation databases

BioMutaiMTX2.

Proteomic databases

EPDiO75431.
MaxQBiO75431.
PaxDbiO75431.
PeptideAtlasiO75431.
PRIDEiO75431.
TopDownProteomicsiO75431-1. [O75431-1]

Protocols and materials databases

DNASUi10651.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000249442; ENSP00000249442; ENSG00000128654. [O75431-1]
GeneIDi10651.
KEGGihsa:10651.
UCSCiuc002ukx.4. human. [O75431-1]

Organism-specific databases

CTDi10651.
DisGeNETi10651.
GeneCardsiMTX2.
H-InvDBHIX0002618.
HGNCiHGNC:7506. MTX2.
HPAiHPA031550.
HPA031551.
HPA031552.
MIMi608555. gene.
neXtProtiNX_O75431.
OpenTargetsiENSG00000128654.
PharmGKBiPA31308.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3027. Eukaryota.
ENOG410XY7W. LUCA.
GeneTreeiENSGT00530000063166.
HOGENOMiHOG000231908.
HOVERGENiHBG003471.
InParanoidiO75431.
KOiK17776.
OMAiPWPENAA.
OrthoDBiEOG091G132X.
PhylomeDBiO75431.
TreeFamiTF313422.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000128654-MONOMER.
ReactomeiR-HSA-1268020. Mitochondrial protein import.

Miscellaneous databases

ChiTaRSiMTX2. human.
GenomeRNAii10651.
PROiO75431.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000128654.
CleanExiHS_MTX2.
ExpressionAtlasiO75431. baseline and differential.
GenevisibleiO75431. HS.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR033468. Metaxin_GST.
IPR019564. Sam37/metaxin_N.
[Graphical view]
PfamiPF17171. GST_C_6. 1 hit.
PF10568. Tom37. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiMTX2_HUMAN
AccessioniPrimary (citable) accession number: O75431
Secondary accession number(s): A8JZZ4
, Q53S50, Q53SQ2, Q5M7Z6, Q8IZ68
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.