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Protein

Leucine-rich repeat and calponin homology domain-containing protein 4

Gene

LRCH4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • nervous system development Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat and calponin homology domain-containing protein 4
Alternative name(s):
Leucine-rich repeat neuronal protein 4
Short name:
Leucine-rich neuronal protein
Gene namesi
Name:LRCH4
Synonyms:LRN, LRRN1, LRRN4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:6691. LRCH4.

Subcellular locationi

GO - Cellular componenti

  • PML body Source: MGI
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi4034.
OpenTargetsiENSG00000077454.
PharmGKBiPA30467.

Polymorphism and mutation databases

BioMutaiLRCH4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000844801 – 683Leucine-rich repeat and calponin homology domain-containing protein 4Add BLAST683

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei279PhosphoserineBy similarity1
Modified residuei281PhosphoserineBy similarity1
Modified residuei304PhosphoserineCombined sources1
Modified residuei307PhosphoserineCombined sources1
Modified residuei309PhosphoserineCombined sources1
Modified residuei313PhosphoserineBy similarity1
Modified residuei432PhosphoserineCombined sources1
Modified residuei457PhosphoserineCombined sources1
Modified residuei511PhosphoserineCombined sources1
Modified residuei513PhosphoserineCombined sources1
Modified residuei517PhosphoserineCombined sources1
Modified residuei521PhosphoserineCombined sources1
Modified residuei589PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO75427.
MaxQBiO75427.
PaxDbiO75427.
PeptideAtlasiO75427.
PRIDEiO75427.

PTM databases

iPTMnetiO75427.
PhosphoSitePlusiO75427.

Miscellaneous databases

PMAP-CutDBO75427.

Expressioni

Gene expression databases

BgeeiENSG00000077454.
CleanExiHS_LRCH4.
HS_LRRN1.
HS_LRRN4.
ExpressionAtlasiO75427. baseline and differential.
GenevisibleiO75427. HS.

Organism-specific databases

HPAiCAB033298.
HPA037667.
HPA037668.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRT40Q6A1623EBI-718707,EBI-10171697
KRTAP10-7P604093EBI-718707,EBI-10172290
KRTAP10-8P604103EBI-718707,EBI-10171774
MDFIQ997503EBI-718707,EBI-724076
NOTCH2NLQ7Z3S93EBI-718707,EBI-945833
SUGT1Q9Y2Z02EBI-718707,EBI-307008

Protein-protein interaction databases

BioGridi110214. 14 interactors.
IntActiO75427. 14 interactors.
STRINGi9606.ENSP00000309689.

Structurei

3D structure databases

ProteinModelPortaliO75427.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati43 – 64LRR 1Add BLAST22
Repeati69 – 90LRR 2Add BLAST22
Repeati92 – 114LRR 3Add BLAST23
Repeati115 – 136LRR 4Add BLAST22
Repeati137 – 158LRR 5Add BLAST22
Repeati160 – 182LRR 6Add BLAST23
Repeati183 – 205LRR 7Add BLAST23
Repeati206 – 226LRR 8Add BLAST21
Repeati228 – 249LRR 9Add BLAST22
Domaini534 – 649CHPROSITE-ProRule annotationAdd BLAST116

Sequence similaritiesi

Contains 1 CH (calponin-homology) domain.PROSITE-ProRule annotation
Contains 9 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0532. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00840000129676.
HOGENOMiHOG000049055.
HOVERGENiHBG052350.
InParanoidiO75427.
OMAiWTTLEAV.
OrthoDBiEOG091G05CB.
PhylomeDBiO75427.
TreeFamiTF318428.

Family and domain databases

CDDicd00014. CH. 1 hit.
Gene3Di1.10.418.10. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR001715. CH-domain.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF00307. CH. 1 hit.
PF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00033. CH. 1 hit.
SM00369. LRR_TYP. 5 hits.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50021. CH. 1 hit.
PS51450. LRR. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O75427-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAVAAPLA AGGEEAAATT SVPGSPGLPG RRSAERALEE AVATGTLNLS
60 70 80 90 100
NRRLKHFPRG AARSYDLSDI TQADLSRNRF PEVPEAACQL VSLEGLSLYH
110 120 130 140 150
NCLRCLNPAL GNLTALTYLN LSRNQLSLLP PYICQLPLRV LIVSNNKLGA
160 170 180 190 200
LPPDIGTLGS LRQLDVSSNE LQSLPSELCG LSSLRDLNVR RNQLSTLPEE
210 220 230 240 250
LGDLPLVRLD FSCNRVSRIP VSFCRLRHLQ VILLDSNPLQ SPPAQVCLKG
260 270 280 290 300
KLHIFKYLST EAGQRGSALG DLAPSRPPSF SPCPAEDLFP GHRYDGGLDS
310 320 330 340 350
GFHSVDSGSK RWSGNESTDE FSELSFRISE LAREPRGPRE RKEDGSADGD
360 370 380 390 400
PVQIDFIDSH VPGEDEERGT VEEQRPPELS PGAGDRERAP SSRREEPAGE
410 420 430 440 450
ERRRPDTLQL WQERERRQQQ QSGAWGAPRK DSLLKPGLRA VVGGAAAVST
460 470 480 490 500
QAMHNGSPKS SASQAGAAAG QGAPAPAPAS QEPLPIAGPA TAPAPRPLGS
510 520 530 540 550
IQRPNSFLFR SSSQSGSGPS SPDSVLRPRR YPQVPDEKDL MTQLRQVLES
560 570 580 590 600
RLQRPLPEDL AEALASGVIL CQLANQLRPR SVPFIHVPSP AVPKLSALKA
610 620 630 640 650
RKNVESFLEA CRKMGVPEAD LCSPSDLLQG TARGLRTALE AVKRVGGKAL
660 670 680
PPLWPPSGLG GFVVFYVVLM LLLYVTYTRL LGS
Length:683
Mass (Da):73,450
Last modified:June 21, 2004 - v2
Checksum:iAF297AA30E4DA353
GO

Sequence cautioni

The sequence AAC78793 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti40E → D in AAC78793 (PubMed:9799793).Curated1
Sequence conflicti391S → N in AAC78793 (PubMed:9799793).Curated1
Sequence conflicti467 – 473AAAGQGA → GCSGAGS in AAC78793 (PubMed:9799793).Curated7
Sequence conflicti682 – 683GS → DP (PubMed:9799793).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051135642V → M.1 PublicationCorresponds to variant rs3197597dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053356 Genomic DNA. Translation: AAC78793.1. Sequence problems.
CH236956 Genomic DNA. Translation: EAL23828.1.
BC007634 mRNA. Translation: AAH07634.1.
BC018529 mRNA. Translation: AAH18529.3.
CCDSiCCDS34706.1.
RefSeqiNP_001276863.1. NM_001289934.1.
NP_002310.2. NM_002319.4.
UniGeneiHs.125742.

Genome annotation databases

EnsembliENST00000310300; ENSP00000309689; ENSG00000077454.
GeneIDi4034.
KEGGihsa:4034.
UCSCiuc003uvj.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053356 Genomic DNA. Translation: AAC78793.1. Sequence problems.
CH236956 Genomic DNA. Translation: EAL23828.1.
BC007634 mRNA. Translation: AAH07634.1.
BC018529 mRNA. Translation: AAH18529.3.
CCDSiCCDS34706.1.
RefSeqiNP_001276863.1. NM_001289934.1.
NP_002310.2. NM_002319.4.
UniGeneiHs.125742.

3D structure databases

ProteinModelPortaliO75427.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110214. 14 interactors.
IntActiO75427. 14 interactors.
STRINGi9606.ENSP00000309689.

PTM databases

iPTMnetiO75427.
PhosphoSitePlusiO75427.

Polymorphism and mutation databases

BioMutaiLRCH4.

Proteomic databases

EPDiO75427.
MaxQBiO75427.
PaxDbiO75427.
PeptideAtlasiO75427.
PRIDEiO75427.

Protocols and materials databases

DNASUi4034.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310300; ENSP00000309689; ENSG00000077454.
GeneIDi4034.
KEGGihsa:4034.
UCSCiuc003uvj.4. human.

Organism-specific databases

CTDi4034.
DisGeNETi4034.
GeneCardsiLRCH4.
HGNCiHGNC:6691. LRCH4.
HPAiCAB033298.
HPA037667.
HPA037668.
neXtProtiNX_O75427.
OpenTargetsiENSG00000077454.
PharmGKBiPA30467.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0532. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00840000129676.
HOGENOMiHOG000049055.
HOVERGENiHBG052350.
InParanoidiO75427.
OMAiWTTLEAV.
OrthoDBiEOG091G05CB.
PhylomeDBiO75427.
TreeFamiTF318428.

Miscellaneous databases

ChiTaRSiLRCH4. human.
GeneWikiiLRCH4.
GenomeRNAii4034.
PMAP-CutDBO75427.
PROiO75427.

Gene expression databases

BgeeiENSG00000077454.
CleanExiHS_LRCH4.
HS_LRRN1.
HS_LRRN4.
ExpressionAtlasiO75427. baseline and differential.
GenevisibleiO75427. HS.

Family and domain databases

CDDicd00014. CH. 1 hit.
Gene3Di1.10.418.10. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR001715. CH-domain.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF00307. CH. 1 hit.
PF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00033. CH. 1 hit.
SM00369. LRR_TYP. 5 hits.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50021. CH. 1 hit.
PS51450. LRR. 7 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLRCH4_HUMAN
AccessioniPrimary (citable) accession number: O75427
Secondary accession number(s): A4D2D5, Q8WV85, Q96ID0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2004
Last sequence update: June 21, 2004
Last modified: November 30, 2016
This is version 141 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.