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Protein

Motile sperm domain-containing protein 3

Gene

MOSPD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Motile sperm domain-containing protein 3
Gene namesi
Name:MOSPD3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000106330.11.
HGNCiHGNC:25078. MOSPD3.
MIMi609125. gene.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei180 – 200HelicalSequence analysisAdd BLAST21
Transmembranei213 – 233HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi64598.
OpenTargetsiENSG00000106330.
PharmGKBiPA134865874.

Polymorphism and mutation databases

BioMutaiMOSPD3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002134651 – 235Motile sperm domain-containing protein 3Add BLAST235

Proteomic databases

MaxQBiO75425.
PaxDbiO75425.
PeptideAtlasiO75425.
PRIDEiO75425.

PTM databases

iPTMnetiO75425.
PhosphoSitePlusiO75425.

Expressioni

Gene expression databases

BgeeiENSG00000106330.
CleanExiHS_MOSPD3.
ExpressionAtlasiO75425. baseline and differential.
GenevisibleiO75425. HS.

Organism-specific databases

HPAiHPA041137.
HPA048240.

Interactioni

Protein-protein interaction databases

IntActiO75425. 5 interactors.
STRINGi9606.ENSP00000223054.

Structurei

3D structure databases

ProteinModelPortaliO75425.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 145MSPPROSITE-ProRule annotationAdd BLAST113

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0439. Eukaryota.
COG5066. LUCA.
GeneTreeiENSGT00390000013613.
HOGENOMiHOG000008144.
HOVERGENiHBG053141.
InParanoidiO75425.
OMAiPENPHPQ.
OrthoDBiEOG091G0YPX.
PhylomeDBiO75425.
TreeFamiTF319778.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiView protein in InterPro
IPR013783. Ig-like_fold.
IPR000535. MSP_dom.
IPR008962. PapD-like_sf.
IPR016763. VAP.
PANTHERiPTHR10809. PTHR10809. 1 hit.
PfamiView protein in Pfam
PF00635. Motile_Sperm. 1 hit.
SUPFAMiSSF49354. SSF49354. 1 hit.
PROSITEiView protein in PROSITE
PS50202. MSP. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75425-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRRGAPQDQE LVGPGPPGRG SRGAPPPLGP VVPVLVFPPD LVFRADQRSG
60 70 80 90 100
PRQLLTLYNP TGTALRFRVL CTAPAKYTVF DAEGYVKPQS CIDIVIRHVA
110 120 130 140 150
PIPSHYDVQD RFRIELSEEG AEGRVVGRKD ITSILRAPAY PLELQGQPDP
160 170 180 190 200
APRPGPPAGT PPPTARHFQE HPRQQLATSS FLLFLLTGIV SVAFLLLPLP
210 220 230
DELGSQLPQV LHVSLGQKLV AAYVLGLLTM VFLRT
Length:235
Mass (Da):25,519
Last modified:November 1, 1998 - v1
Checksum:i405D69B8309C4FAF
GO
Isoform 2 (identifier: O75425-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: MRRGAPQDQELVGPGPPGRGSRG → MSDRPEPAC

Note: Gene prediction confirmed by EST data.
Show »
Length:221
Mass (Da):24,148
Checksum:i3E09D222B8C831B1
GO
Isoform 3 (identifier: O75425-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: Missing.
     54-68: LLTLYNPTGTALRFR → MTHMAGLVCVCLYPP

Note: Gene prediction confirmed by EST data.
Show »
Length:182
Mass (Da):19,855
Checksum:i539793EA583AD1A3
GO
Isoform 4 (identifier: O75425-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     95-104: Missing.

Note: Gene prediction confirmed by EST data.
Show »
Length:225
Mass (Da):24,448
Checksum:i7752A894A9D387A1
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0140541 – 53Missing in isoform 3. CuratedAdd BLAST53
Alternative sequenceiVSP_0140531 – 23MRRGA…RGSRG → MSDRPEPAC in isoform 2. CuratedAdd BLAST23
Alternative sequenceiVSP_01405554 – 68LLTLY…ALRFR → MTHMAGLVCVCLYPP in isoform 3. CuratedAdd BLAST15
Alternative sequenceiVSP_04452295 – 104Missing in isoform 4. 1 Publication10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053356 Genomic DNA. Translation: AAC78797.1.
AF053356 Genomic DNA. Translation: AAC78798.1.
AF053356 Genomic DNA. Translation: AAC78799.1.
AC099394 Genomic DNA. No translation available.
CH236956 Genomic DNA. Translation: EAL23824.1.
CH471091 Genomic DNA. Translation: EAW76511.1.
CH471091 Genomic DNA. Translation: EAW76512.1.
CH471091 Genomic DNA. Translation: EAW76513.1.
BC005042 mRNA. Translation: AAH05042.1.
BC011653 mRNA. Translation: AAH11653.1.
BC028475 mRNA. No translation available.
CCDSiCCDS47662.1. [O75425-4]
CCDS5701.1. [O75425-1]
RefSeqiNP_001035186.1. NM_001040097.1. [O75425-1]
NP_001035187.1. NM_001040098.1. [O75425-1]
NP_001035188.1. NM_001040099.1. [O75425-4]
NP_076438.1. NM_023948.4. [O75425-1]
XP_005250586.1. XM_005250529.4. [O75425-1]
XP_005250588.1. XM_005250531.3. [O75425-1]
UniGeneiHs.521086.

Genome annotation databases

EnsembliENST00000223054; ENSP00000223054; ENSG00000106330. [O75425-1]
ENST00000379527; ENSP00000368842; ENSG00000106330. [O75425-1]
ENST00000393950; ENSP00000377522; ENSG00000106330. [O75425-1]
ENST00000424091; ENSP00000404626; ENSG00000106330. [O75425-4]
GeneIDi64598.
KEGGihsa:64598.
UCSCiuc003uvq.4. human. [O75425-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMSPD3_HUMAN
AccessioniPrimary (citable) accession number: O75425
Secondary accession number(s): A4D2D1
, A6NG17, C9JE89, D6W5W1, O75423, O75424
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: November 1, 1998
Last modified: November 22, 2017
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot