CDC45-related protein - Homo sapiens (Human)

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Reviewed, UniProtKB/Swiss-Prot O75419 (CC45L_HUMAN)

Last modified November 25, 2008. Version 71. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    CDC45-related protein
      Short name=Cdc45
Alternative name(s):
    PORC-PI-1

Gene names

Name:	CDC45L
Synonyms:	CDC45L2
ORF Names:	UNQ374/PRO710

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	566 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Required for initiation of chromosomal DNA replication.
Subunit structure	Associated with ORC2L.
Subcellular location	Cytoplasm. Nucleus.
Tissue specificity	Widely expressed, highest levels are found in adult testis and tyhmus and in fetal liver.
Developmental stage	Transcript peaks at G1-S transition, but total protein remains constant throughout the cell cycle. Expressed in multiple tissues during embryogenesis, including neural crest-derived structures.
Sequence similarities	Belongs to the CDC45 family.

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Ontologies

Keywords
Biological process	Cell cycle DNA replication
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Polymorphism
Gene Ontology (GO)
Biological process	DNA replication checkpoint Ref.2 Traceable author statement. Source: ProtInc
Cellular component	centrosome Inferred from direct assay. Source: HPA nucleoplasm Inferred from Experiment. Source: Reactome
Molecular function	protein binding Inferred from physical interaction. Source: UniProtKB
Complete GO annotation...

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Binary interactions

With	Entry	#Exp.	IntAct
CDKN1A	P38936	1	EBI-374969,EBI-375077
CDKN2A	P42771	1	EBI-374969,EBI-375053
MCM10	Q7L590	1	EBI-374969,EBI-374912
ORC3L	Q9UBD5	1	EBI-374969,EBI-374916
ORC5L	O43913	1	EBI-374969,EBI-374928
TOPBP1	Q92547	2	EBI-374969,EBI-308302

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 566

566

CDC45-related protein

PRO_0000192815

Natural variations

Natural variant

V → I: dbSNP rs13447203.

VAR_019286

Natural variant

376

V → M: dbSNP rs13447263.

VAR_019287

Experimental info

Sequence conflict

100

T → S in AAQ89330. Ref.5

Sequence conflict

115

I → V in CAA11530. Ref.3

Sequence conflict

346

E → Q in AAC67521. Ref.1

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Sequences

Sequence

Length

Mass (Da)

Tools

O75419-1 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: AE1BE2C8C8E5F867
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FASTA

566

65,569

        10         20         30         40         50         60 
MFVSDFRKEF YEVVQSQRVL LFVASDVDAL CACKILQALF QCDHVQYTLV PVSGWQELET 

        70         80         90        100        110        120 
AFLEHKEQFH YFILINCGAN VDLLDILQPD EDTIFFVCDT HRPVNVVNVY NDTQIKLLIK 

       130        140        150        160        170        180 
QDDDLEVPAY EDIFRDEEED EEHSGNDSDG SEPSEKRTRL EEEIVEQTMR RRQRREWEAR 

       190        200        210        220        230        240 
RRDILFDYEQ YEYHGTSSAM VMFELAWMLS KDLNDMLWWA IVGLTDQWVQ DKITQMKYVT 

       250        260        270        280        290        300 
DVGVLQRHVS RHNHRNEDEE NTLSVDCTRI SFEYDLRLVL YQHWSLHDSL CNTSYTAARF 

       310        320        330        340        350        360 
KLWSVHGQKR LQEFLADMGL PLKQVKQKFQ AMDISLKENL REMIEESANK FGMKDMRVQT 

       370        380        390        400        410        420 
FSIHFGFKHK FLASDVVFAT MSLMESPEKD GSGTDHFIQA LDSLSRSNLD KLYHGLELAK 

       430        440        450        460        470        480 
KQLRATQQTI ASCLCTNLVI SQGPFLYCSL MEGTPDVMLF SRPASLSLLS KHLLKSFVCS 

       490        500        510        520        530        540 
TKNRRCKLLP LVMAAPLSME HGTVTVVGIP PETDSSDRKN FFGRAFEKAA ESTSSRMLHN 

       550        560 
HFDLSVIELK AEDRSKFLDA LISLLS

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Xenopus Cdc45-dependent loading of DNA polymerase alpha onto chromatin under the control of S-phase Cdk." Mimura S., Takisawa H. EMBO J. 17:5699-5707(1998) [PubMed: 9755170] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The human homolog of Saccharomyces cerevisiae CDC45." Saha P., Thome K.C., Yamaguchi R., Hou Z.-H., Weremowicz S., Dutta A. J. Biol. Chem. 273:18205-18209(1998) [PubMed: 9660782] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Direct selection of conserved cDNAs from the DiGeorge critical region: isolation of a novel CDC45-like gene." McKie J.M., Wadey R.B., Sutherland H.F., Taylor C.L., Scambler P.J. Genome Res. 8:834-841(1998) [PubMed: 9724329] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"Characterization of CDC45L: a gene in the 22q11.2 deletion region expressed during murine and human development." Shaikh T.H., Gottlieb S., Sellinger B., Chen F., Roe B.A., Oakey R.J., Emanuel B.S., Budarf M.L. Mamm. Genome 10:322-326(1999) [PubMed: 10051334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[5]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[7]	"NIEHS-SNPs, environmental genome project, NIEHS ES15478, Department of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu)." Livingston R.J., Rieder M.J., Chung M.-W., Ritchie T.K., Olson A.N., Nguyen C.P., Nguyen D.A., Poel C.L., Robertson P.D., Schackwitz W.S., Sherwood J.K., Sherwood A.M., Leithauser B.J., Nickerson D.A. Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ILE-81 AND MET-376.
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung and Muscle.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
	AF062495 mRNA. Translation: AAC67521.1. AF053074 mRNA. Translation: AAC27289.1. AJ223728 mRNA. Translation: CAA11530.1. AF081535 mRNA. Translation: AAD08998.1. AY358971 mRNA. Translation: AAQ89330.1. BT006792 mRNA. Translation: AAP35438.1. AY572790 Genomic DNA. Translation: AAS66985.1. BC006232 mRNA. Translation: AAH06232.1. BC010022 mRNA. Translation: AAH10022.1.
RefSeq	NP_003495.1.
UniGene	Hs.474217
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	O75419.
PTM databases
PhosphoSite	O75419.
Polymorphism databases
NIEHS-SNPs	Search...
Proteomic databases
PeptideAtlas	O75419.
Genome annotation databases
Ensembl	ENSG00000093009. Homo sapiens. [Contig view]
GeneID	8318.
KEGG	hsa:8318.
Organism-specific databases
H-InvDB	HIX0016238.
HGNC	HGNC:1739. CDC45L.
HPA	CAB009459. HPA000614.
MIM	603465. gene.
PharmGKB	PA371.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	O75419.
HOVERGEN	O75419.
Enzyme and pathway databases
Reactome	REACT_152. Cell Cycle, Mitotic. REACT_1538. Cell Cycle Checkpoints. REACT_383. DNA Replication.
Gene expression databases
ArrayExpress	O75419.
CleanEx	HS_CDC45L.
GermOnline	ENSG00000093009. Homo sapiens.
Family and domain databases
InterPro	IPR003874. CDC45_like. [Graphical view]
PANTHER	PTHR10507. CDC45_like. 1 hit.
Pfam	PF02724. CDC45. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	31151.
SOURCE	Search...

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Entry information

Entry name

CC45L_HUMAN

Accession

Primary (citable) accession number: O75419
Secondary accession number(s): O60856, Q6UW54, Q9UP68

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1998
Last modified:	November 25, 2008
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 22

Human chromosome 22: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Keywords

Gene Ontology (GO)

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Natural variations

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents