O75419 (CDC45_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cell division control protein 45 homolog

Alternative name(s):
PORC-PI-1

Gene names

Name:	CDC45
Synonyms:	CDC45L, CDC45L2
ORF Names:	UNQ374/PRO710

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	566 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Required for initiation of chromosomal DNA replication.
Subunit structure	Associated with ORC2.
Subcellular location	Cytoplasm. Nucleus.
Tissue specificity	Widely expressed, highest levels are found in adult testis and thymus and in fetal liver.
Developmental stage	Transcript peaks at G1-S transition, but total protein remains constant throughout the cell cycle. Expressed in multiple tissues during embryogenesis, including neural crest-derived structures.
Sequence similarities	Belongs to the CDC45 family.

Ontologies

Keywords
Biological process	Cell cycle DNA replication
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA replication checkpoint Traceable author statement Ref.2. Source: ProtInc DNA replication initiation Traceable author statement Ref.2. Source: ProtInc DNA strand elongation involved in DNA replication Traceable author statement. Source: Reactome S phase of mitotic cell cycle Traceable author statement. Source: Reactome regulation of transcription involved in G1/S phase of mitotic cell cycle Traceable author statement. Source: Reactome
Cellular_component	centrosome Inferred from direct assay. Source: HPA cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleoplasm Traceable author statement. Source: Reactome
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
TOPBP1	Q92547	6	EBI-374969,EBI-308302

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O75419-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O75419-2)

The sequence of this isoform differs from the canonical sequence as follows:
     68-113: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: O75419-3)

The sequence of this isoform differs from the canonical sequence as follows:
     180-180: R → RSGSGSEPVAAALEKSSRLFAGPMSDRTAPRSP

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 566	566	Cell division control protein 45 homolog		PRO_0000192815
Amino acid modifications
	Modified residue	130	1	Phosphotyrosine Ref.13
	Modified residue	144	1	Phosphoserine Ref.13
	Modified residue	148	1	Phosphoserine Ref.13
Natural variations
	Alternative sequence	68 – 113	46	Missing in isoform 2.		VSP_043129
	Alternative sequence	180	1	R → RSGSGSEPVAAALEKSSRLF AGPMSDRTAPRSP in isoform 3.		VSP_045411
	Natural variant	81	1	V → I. Ref.8 Corresponds to variant rs13447203 [ dbSNP | Ensembl ].		VAR_019286
	Natural variant	356	1	M → R. Corresponds to variant rs17209274 [ dbSNP | Ensembl ].		VAR_053026
	Natural variant	376	1	V → M. Ref.8 Corresponds to variant rs13447263 [ dbSNP | Ensembl ].		VAR_019287
Experimental info
	Sequence conflict	100	1	T → S in AAQ89330. Ref.5
	Sequence conflict	115	1	I → V in CAA11530. Ref.3
	Sequence conflict	346	1	E → Q in AAC67521. Ref.1
	Sequence conflict	509	1	I → F in BAG56854. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: AE1BE2C8C8E5F867	FASTA	566	65,569
	10 20 30 40 50 60 MFVSDFRKEF YEVVQSQRVL LFVASDVDAL CACKILQALF QCDHVQYTLV PVSGWQELET 70 80 90 100 110 120 AFLEHKEQFH YFILINCGAN VDLLDILQPD EDTIFFVCDT HRPVNVVNVY NDTQIKLLIK 130 140 150 160 170 180 QDDDLEVPAY EDIFRDEEED EEHSGNDSDG SEPSEKRTRL EEEIVEQTMR RRQRREWEAR 190 200 210 220 230 240 RRDILFDYEQ YEYHGTSSAM VMFELAWMLS KDLNDMLWWA IVGLTDQWVQ DKITQMKYVT 250 260 270 280 290 300 DVGVLQRHVS RHNHRNEDEE NTLSVDCTRI SFEYDLRLVL YQHWSLHDSL CNTSYTAARF 310 320 330 340 350 360 KLWSVHGQKR LQEFLADMGL PLKQVKQKFQ AMDISLKENL REMIEESANK FGMKDMRVQT 370 380 390 400 410 420 FSIHFGFKHK FLASDVVFAT MSLMESPEKD GSGTDHFIQA LDSLSRSNLD KLYHGLELAK 430 440 450 460 470 480 KQLRATQQTI ASCLCTNLVI SQGPFLYCSL MEGTPDVMLF SRPASLSLLS KHLLKSFVCS 490 500 510 520 530 540 TKNRRCKLLP LVMAAPLSME HGTVTVVGIP PETDSSDRKN FFGRAFEKAA ESTSSRMLHN 550 560 HFDLSVIELK AEDRSKFLDA LISLLS
	Isoform 2 [UniParc]. Checksum: BE5CE1F95079C2E6	FASTA	520	60,245
	10 20 30 40 50 60 MFVSDFRKEF YEVVQSQRVL LFVASDVDAL CACKILQALF QCDHVQYTLV PVSGWQELET 70 80 90 100 110 120 AFLEHKEQIK LLIKQDDDLE VPAYEDIFRD EEEDEEHSGN DSDGSEPSEK RTRLEEEIVE 130 140 150 160 170 180 QTMRRRQRRE WEARRRDILF DYEQYEYHGT SSAMVMFELA WMLSKDLNDM LWWAIVGLTD 190 200 210 220 230 240 QWVQDKITQM KYVTDVGVLQ RHVSRHNHRN EDEENTLSVD CTRISFEYDL RLVLYQHWSL 250 260 270 280 290 300 HDSLCNTSYT AARFKLWSVH GQKRLQEFLA DMGLPLKQVK QKFQAMDISL KENLREMIEE 310 320 330 340 350 360 SANKFGMKDM RVQTFSIHFG FKHKFLASDV VFATMSLMES PEKDGSGTDH FIQALDSLSR 370 380 390 400 410 420 SNLDKLYHGL ELAKKQLRAT QQTIASCLCT NLVISQGPFL YCSLMEGTPD VMLFSRPASL 430 440 450 460 470 480 SLLSKHLLKS FVCSTKNRRC KLLPLVMAAP LSMEHGTVTV VGIPPETDSS DRKNFFGRAF 490 500 510 520 EKAAESTSSR MLHNHFDLSV IELKAEDRSK FLDALISLLS
	Isoform 3 [UniParc]. Checksum: 2625590397EB6E6B	FASTA	598	68,768
	10 20 30 40 50 60 MFVSDFRKEF YEVVQSQRVL LFVASDVDAL CACKILQALF QCDHVQYTLV PVSGWQELET 70 80 90 100 110 120 AFLEHKEQFH YFILINCGAN VDLLDILQPD EDTIFFVCDT HRPVNVVNVY NDTQIKLLIK 130 140 150 160 170 180 QDDDLEVPAY EDIFRDEEED EEHSGNDSDG SEPSEKRTRL EEEIVEQTMR RRQRREWEAR 190 200 210 220 230 240 SGSGSEPVAA ALEKSSRLFA GPMSDRTAPR SPRRDILFDY EQYEYHGTSS AMVMFELAWM 250 260 270 280 290 300 LSKDLNDMLW WAIVGLTDQW VQDKITQMKY VTDVGVLQRH VSRHNHRNED EENTLSVDCT 310 320 330 340 350 360 RISFEYDLRL VLYQHWSLHD SLCNTSYTAA RFKLWSVHGQ KRLQEFLADM GLPLKQVKQK 370 380 390 400 410 420 FQAMDISLKE NLREMIEESA NKFGMKDMRV QTFSIHFGFK HKFLASDVVF ATMSLMESPE 430 440 450 460 470 480 KDGSGTDHFI QALDSLSRSN LDKLYHGLEL AKKQLRATQQ TIASCLCTNL VISQGPFLYC 490 500 510 520 530 540 SLMEGTPDVM LFSRPASLSL LSKHLLKSFV CSTKNRRCKL LPLVMAAPLS MEHGTVTVVG 550 560 570 580 590 IPPETDSSDR KNFFGRAFEK AAESTSSRML HNHFDLSVIE LKAEDRSKFL DALISLLS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Xenopus Cdc45-dependent loading of DNA polymerase alpha onto chromatin under the control of S-phase Cdk." Mimura S., Takisawa H. EMBO J. 17:5699-5707(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"The human homolog of Saccharomyces cerevisiae CDC45." Saha P., Thome K.C., Yamaguchi R., Hou Z.-H., Weremowicz S., Dutta A. J. Biol. Chem. 273:18205-18209(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]	"Direct selection of conserved cDNAs from the DiGeorge critical region: isolation of a novel CDC45-like gene." McKie J.M., Wadey R.B., Sutherland H.F., Taylor C.L., Scambler P.J. Genome Res. 8:834-841(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[4]	"Characterization of CDC45L: a gene in the 22q11.2 deletion region expressed during murine and human development." Shaikh T.H., Gottlieb S., Sellinger B., Chen F., Roe B.A., Oakey R.J., Emanuel B.S., Budarf M.L. Mamm. Genome 10:322-326(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Brain.
[5]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[6]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
[7]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[8]	NIEHS SNPs program Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ILE-81 AND MET-376.
[9]	"A genome annotation-driven approach to cloning the human ORFeome." Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I. Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[10]	"The DNA sequence of human chromosome 22." Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H. Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[11]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[12]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Lung and Muscle.
[13]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-130; SER-144 AND SER-148, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[14]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Web resources

NIEHS-SNPs

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF062495 mRNA. Translation: AAC67521.1. AF053074 mRNA. Translation: AAC27289.1. AJ223728 mRNA. Translation: CAA11530.1. AF081535 mRNA. Translation: AAD08998.1. AY358971 mRNA. Translation: AAQ89330.1. AK293123 mRNA. Translation: BAG56675.1. AK293338 mRNA. Translation: BAG56854.1. BT006792 mRNA. Translation: AAP35438.1. AY572790 Genomic DNA. Translation: AAS66985.1. CT841513 mRNA. Translation: CAJ86443.1. AC000082 Genomic DNA. No translation available. AC000087 Genomic DNA. No translation available. AC000088 Genomic DNA. No translation available. CH471176 Genomic DNA. Translation: EAX03036.1. BC006232 mRNA. Translation: AAH06232.1. BC010022 mRNA. Translation: AAH10022.1.
IPI	IPI00025695. IPI00878645. IPI00909930.
RefSeq	NP_001171481.1. NM_001178010.1. NP_001171482.1. NM_001178011.1. NP_003495.1. NM_003504.3.
UniGene	Hs.474217.
3D structure databases
ProteinModelPortal	O75419.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-31725N.
IntAct	O75419. 10 interactions.
MINT	MINT-1201326.
PTM databases
PhosphoSite	O75419.
Proteomic databases
PaxDb	O75419.
PeptideAtlas	O75419.
PRIDE	O75419.
Protocols and materials databases
DNASU	8318.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000263201; ENSP00000263201; ENSG00000093009. ENST00000404724; ENSP00000384978; ENSG00000093009. ENST00000407835; ENSP00000385240; ENSG00000093009. ENST00000437685; ENSP00000405726; ENSG00000093009.
GeneID	8318.
KEGG	hsa:8318.
UCSC	uc002zpr.3. human. uc002zpt.3. human. uc011aha.2. human.
Organism-specific databases
CTD	8318.
GeneCards	GC22P019466.
HGNC	HGNC:1739. CDC45.
HPA	CAB009459. HPA000614.
MIM	603465. gene.
neXtProt	NX_O75419.
PharmGKB	PA371.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG321683.
HOGENOM	HOG000253949.
HOVERGEN	HBG050819.
InParanoid	O75419.
KO	K06628.
OrthoDB	EOG45756G.
PhylomeDB	O75419.
Enzyme and pathway databases
Reactome	REACT_115566. Cell Cycle. REACT_21300. Mitotic M-M/G1 phases. REACT_383. DNA Replication.
Gene expression databases
ArrayExpress	O75419.
Bgee	O75419.
CleanEx	HS_CDC45L.
Genevestigator	O75419.
GermOnline	ENSG00000093009. Homo sapiens.
Family and domain databases
InterPro	IPR003874. CDC45. [Graphical view]
PANTHER	PTHR10507. PTHR10507. 1 hit.
Pfam	PF02724. CDC45. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	O75419.
ChEMBL	CHEMBL3040.
GenomeRNAi	8318.
NextBio	31151.
SOURCE	Search...

Entry information

Entry name

CDC45_HUMAN

Accession

Primary (citable) accession number: O75419
Secondary accession number(s): B4DDB4 , B4DDU3, E9PDH7, O60856, Q20WK8, Q6UW54, Q9UP68

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1998
Last modified:	May 29, 2013
This is version 115 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.