O75417 (DPOLQ_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DNA polymerase theta
EC=2.7.7.7

Alternative name(s):
DNA polymerase eta

Gene names

Name:	POLQ
Synonyms:	POLH

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	2590 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Has a DNA polymerase activity on nicked double-stranded DNA and on a singly primed DNA template. The enzyme activity is resistant to aphidicolin, and inhibited by dideoxynucleotides. Exhibites a single-stranded DNA-dependent ATPase activity. Could be involved in the repair of interstrand cross-links. Ref.2
Catalytic activity	Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
Tissue specificity	Highly expressed in testis. Ref.2
Sequence similarities	Belongs to the DNA polymerase type-A family. Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain.
Sequence caution	The sequence AAD05272.1 differs from that shown. Reason: Frameshift at position 1754.

Ontologies

Keywords
Biological process	DNA damage DNA repair
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
Ligand	ATP-binding Nucleotide-binding
Molecular function	DNA-directed DNA polymerase Nucleotidyltransferase Transferase
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA repair Traceable author statement Ref.1. Source: ProtInc DNA replication Inferred from electronic annotation. Source: InterPro
Cellular_component	nucleoplasm Traceable author statement Ref.1. Source: ProtInc
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATP-dependent helicase activity Inferred from electronic annotation. Source: InterPro DNA-directed DNA polymerase activity Inferred from direct assay Ref.2. Source: UniProtKB damaged DNA binding Traceable author statement Ref.1. Source: ProtInc single-stranded DNA-dependent ATPase activity Inferred from direct assay Ref.2. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O75417-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O75417-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-828: Missing.
     829-840: VEVILKNAVPFK → MNSFLSFPISLC

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2590	2590	DNA polymerase theta		PRO_0000101279
Regions
	Domain	102 – 286	185	Helicase ATP-binding
	Domain	321 – 554	234	Helicase C-terminal
	Nucleotide binding	115 – 122	8	ATP By similarity
	Coiled coil	1655 – 1716	62	Potential
	Motif	216 – 219	4	DEAH box
Amino acid modifications
	Modified residue	990	1	N6-acetyllysine Ref.5
Natural variations
	Alternative sequence	1 – 828	828	Missing in isoform 2.		VSP_040747
	Alternative sequence	829 – 840	12	VEVIL…AVPFK → MNSFLSFPISLC in isoform 2.		VSP_040748
	Natural variant	1056	1	P → L. Corresponds to variant rs34778629 [ dbSNP | Ensembl ].		VAR_055707
Experimental info
	Sequence conflict	66	1	R → I in AAR08421. Ref.2
	Sequence conflict	982	1	T → R in AAR08421. Ref.2
	Sequence conflict	2013	1	L → F in AAD05272. Ref.4
	Sequence conflict	2513	1	Q → R in AAC33565. Ref.1
	Sequence conflict	2513	1	Q → R in AAR08421. Ref.2
	Sequence conflict	2547	1	A → V in AAC33565. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 8, 2011. Version 2. Checksum: F5550BED2DAD8013	FASTA	2,590	289,619
	10 20 30 40 50 60 MNLLRRSGKR RRSESGSDSF SGSGGDSSAS PQFLSGSVLS PPPGLGRCLK AAAAGECKPT 70 80 90 100 110 120 VPDYERDKLL LANWGLPKAV LEKYHSFGVK KMFEWQAECL LLGQVLEGKN LVYSAPTSAG 130 140 150 160 170 180 KTLVAELLIL KRVLEMRKKA LFILPFVSVA KEKKYYLQSL FQEVGIKVDG YMGSTSPSRH 190 200 210 220 230 240 FSSLDIAVCT IERANGLINR LIEENKMDLL GMVVVDELHM LGDSHRGYLL ELLLTKICYI 250 260 270 280 290 300 TRKSASCQAD LASSLSNAVQ IVGMSATLPN LELVASWLNA ELYHTDFRPV PLLESVKVGN 310 320 330 340 350 360 SIYDSSMKLV REFEPMLQVK GDEDHVVSLC YETICDNHSV LLFCPSKKWC EKLADIIARE 370 380 390 400 410 420 FYNLHHQAEG LVKPSECPPV ILEQKELLEV MDQLRRLPSG LDSVLQKTVP WGVAFHHAGL 430 440 450 460 470 480 TFEERDIIEG AFRQGLIRVL AATSTLSSGV NLPARRVIIR TPIFGGRPLD ILTYKQMVGR 490 500 510 520 530 540 AGRKGVDTVG ESILICKNSE KSKGIALLQG SLKPVRSCLQ RREGEEVTGS MIRAILEIIV 550 560 570 580 590 600 GGVASTSQDM HTYAACTFLA ASMKEGKQGI QRNQESVQLG AIEACVMWLL ENEFIQSTEA 610 620 630 640 650 660 SDGTEGKVYH PTHLGSATLS SSLSPADTLD IFADLQRAMK GFVLENDLHI LYLVTPMFED 670 680 690 700 710 720 WTTIDWYRFF CLWEKLPTSM KRVAELVGVE EGFLARCVKG KVVARTERQH RQMAIHKRFF 730 740 750 760 770 780 TSLVLLDLIS EVPLREINQK YGCNRGQIQS LQQSAAVYAG MITVFSNRLG WHNMELLLSQ 790 800 810 820 830 840 FQKRLTFGIQ RELCDLVRVS LLNAQRARVL YASGFHTVAD LARANIVEVE VILKNAVPFK 850 860 870 880 890 900 SARKAVDEEE EAVEERRNMR TIWVTGRKGL TEREAAALIV EEARMILQQD LVEMGVQWNP 910 920 930 940 950 960 CALLHSSTCS LTHSESEVKE HTFISQTKSS YKKLTSKNKS NTIFSDSYIK HSPNIVQDLN 970 980 990 1000 1010 1020 KSREHTSSFN CNFQNGNQEH QTCSIFRARK RASLDINKEK PGASQNEGKT SDKKVVQTFS 1030 1040 1050 1060 1070 1080 QKTKKAPLNF NSEKMSRSFR SWKRRKHLKR SRDSSPLKDS GACRIHLQGQ TLSNPSLCED 1090 1100 1110 1120 1130 1140 PFTLDEKKTE FRNSGPFAKN VSLSGKEKDN KTSFPLQIKQ NCSWNITLTN DNFVEHIVTG 1150 1160 1170 1180 1190 1200 SQSKNVTCQA TSVVSEKGRG VAVEAEKINE VLIQNGSKNQ NVYMKHHDIH PINQYLRKQS 1210 1220 1230 1240 1250 1260 HEQTSTITKQ KNIIERQMPC EAVSSYINRD SNVTINCERI KLNTEENKPS HFQALGDDIS 1270 1280 1290 1300 1310 1320 RTVIPSEVLP SAGAFSKSEG QHENFLNISR LQEKTGTYTT NKTKNNHVSD LGLVLCDFED 1330 1340 1350 1360 1370 1380 SFYLDTQSEK IIQQMATENA KLGAKDTNLA AGIMQKSLVQ QNSMNSFQKE CHIPFPAEQH 1390 1400 1410 1420 1430 1440 PLGATKIDHL DLKTVGTMKQ SSDSHGVDIL TPESPIFHSP ILLEENGLFL KKNEVSVTDS 1450 1460 1470 1480 1490 1500 QLNSFLQGYQ TQETVKPVIL LIPQKRTPTG VEGECLPVPE TSLNMSDSLL FDSFSDDYLV 1510 1520 1530 1540 1550 1560 KEQLPDMQMK EPLPSEVTSN HFSDSLCLQE DLIKKSNVNE NQDTHQQLTC SNDESIIFSE 1570 1580 1590 1600 1610 1620 MDSVQMVEAL DNVDIFPVQE KNHTVVSPRA LELSDPVLDE HHQGDQDGGD QDERAEKSKL 1630 1640 1650 1660 1670 1680 TGTRQNHSFI WSGASFDLSP GLQRILDKVS SPLENEKLKS MTINFSSLNR KNTELNEEQE 1690 1700 1710 1720 1730 1740 VISNLETKQV QGISFSSNNE VKSKIEMLEN NANHDETSSL LPRKESNIVD DNGLIPPTPI 1750 1760 1770 1780 1790 1800 PTSASKLTFP GILETPVNPW KTNNVLQPGE SYLFGSPSDI KNHDLSPGSR NGFKDNSPIS 1810 1820 1830 1840 1850 1860 DTSFSLQLSQ DGLQLTPASS SSESLSIIDV ASDQNLFQTF IKEWRCKKRF SISLACEKIR 1870 1880 1890 1900 1910 1920 SLTSSKTATI GSRFKQASSP QEIPIRDDGF PIKGCDDTLV VGLAVCWGGR DAYYFSLQKE 1930 1940 1950 1960 1970 1980 QKHSEISASL VPPSLDPSLT LKDRMWYLQS CLRKESDKEC SVVIYDFIQS YKILLLSCGI 1990 2000 2010 2020 2030 2040 SLEQSYEDPK VACWLLDPDS QEPTLHSIVT SFLPHELPLL EGMETSQGIQ SLGLNAGSEH 2050 2060 2070 2080 2090 2100 SGRYRASVES ILIFNSMNQL NSLLQKENLQ DVFRKVEMPS QYCLALLELN GIGFSTAECE 2110 2120 2130 2140 2150 2160 SQKHIMQAKL DAIETQAYQL AGHSFSFTSS DDIAEVLFLE LKLPPNREMK NQGSKKTLGS 2170 2180 2190 2200 2210 2220 TRRGIDNGRK LRLGRQFSTS KDVLNKLKAL HPLPGLILEW RRITNAITKV VFPLQREKCL 2230 2240 2250 2260 2270 2280 NPFLGMERIY PVSQSHTATG RITFTEPNIQ NVPRDFEIKM PTLVGESPPS QAVGKGLLPM 2290 2300 2310 2320 2330 2340 GRGKYKKGFS VNPRCQAQME ERAADRGMPF SISMRHAFVP FPGGSILAAD YSQLELRILA 2350 2360 2370 2380 2390 2400 HLSHDRRLIQ VLNTGADVFR SIAAEWKMIE PESVGDDLRQ QAKQICYGII YGMGAKSLGE 2410 2420 2430 2440 2450 2460 QMGIKENDAA CYIDSFKSRY TGINQFMTET VKNCKRDGFV QTILGRRRYL PGIKDNNPYR 2470 2480 2490 2500 2510 2520 KAHAERQAIN TIVQGSAADI VKIATVNIQK QLETFHSTFK SHGHREGMLQ SDQTGLSRKR 2530 2540 2550 2560 2570 2580 KLQGMFCPIR GGFFILQLHD ELLYEVAEED VVQVAQIVKN EMESAVKLSV KLKVKVKIGA 2590 SWGELKDFDV
	Isoform 2 [UniParc]. Checksum: ACA2EA21B2B69C15	FASTA	1,762	197,541
	10 20 30 40 50 60 MNSFLSFPIS LCSARKAVDE EEEAVEERRN MRTIWVTGRK GLTEREAAAL IVEEARMILQ 70 80 90 100 110 120 QDLVEMGVQW NPCALLHSST CSLTHSESEV KEHTFISQTK SSYKKLTSKN KSNTIFSDSY 130 140 150 160 170 180 IKHSPNIVQD LNKSREHTSS FNCNFQNGNQ EHQTCSIFRA RKRASLDINK EKPGASQNEG 190 200 210 220 230 240 KTSDKKVVQT FSQKTKKAPL NFNSEKMSRS FRSWKRRKHL KRSRDSSPLK DSGACRIHLQ 250 260 270 280 290 300 GQTLSNPSLC EDPFTLDEKK TEFRNSGPFA KNVSLSGKEK DNKTSFPLQI KQNCSWNITL 310 320 330 340 350 360 TNDNFVEHIV TGSQSKNVTC QATSVVSEKG RGVAVEAEKI NEVLIQNGSK NQNVYMKHHD 370 380 390 400 410 420 IHPINQYLRK QSHEQTSTIT KQKNIIERQM PCEAVSSYIN RDSNVTINCE RIKLNTEENK 430 440 450 460 470 480 PSHFQALGDD ISRTVIPSEV LPSAGAFSKS EGQHENFLNI SRLQEKTGTY TTNKTKNNHV 490 500 510 520 530 540 SDLGLVLCDF EDSFYLDTQS EKIIQQMATE NAKLGAKDTN LAAGIMQKSL VQQNSMNSFQ 550 560 570 580 590 600 KECHIPFPAE QHPLGATKID HLDLKTVGTM KQSSDSHGVD ILTPESPIFH SPILLEENGL 610 620 630 640 650 660 FLKKNEVSVT DSQLNSFLQG YQTQETVKPV ILLIPQKRTP TGVEGECLPV PETSLNMSDS 670 680 690 700 710 720 LLFDSFSDDY LVKEQLPDMQ MKEPLPSEVT SNHFSDSLCL QEDLIKKSNV NENQDTHQQL 730 740 750 760 770 780 TCSNDESIIF SEMDSVQMVE ALDNVDIFPV QEKNHTVVSP RALELSDPVL DEHHQGDQDG 790 800 810 820 830 840 GDQDERAEKS KLTGTRQNHS FIWSGASFDL SPGLQRILDK VSSPLENEKL KSMTINFSSL 850 860 870 880 890 900 NRKNTELNEE QEVISNLETK QVQGISFSSN NEVKSKIEML ENNANHDETS SLLPRKESNI 910 920 930 940 950 960 VDDNGLIPPT PIPTSASKLT FPGILETPVN PWKTNNVLQP GESYLFGSPS DIKNHDLSPG 970 980 990 1000 1010 1020 SRNGFKDNSP ISDTSFSLQL SQDGLQLTPA SSSSESLSII DVASDQNLFQ TFIKEWRCKK 1030 1040 1050 1060 1070 1080 RFSISLACEK IRSLTSSKTA TIGSRFKQAS SPQEIPIRDD GFPIKGCDDT LVVGLAVCWG 1090 1100 1110 1120 1130 1140 GRDAYYFSLQ KEQKHSEISA SLVPPSLDPS LTLKDRMWYL QSCLRKESDK ECSVVIYDFI 1150 1160 1170 1180 1190 1200 QSYKILLLSC GISLEQSYED PKVACWLLDP DSQEPTLHSI VTSFLPHELP LLEGMETSQG 1210 1220 1230 1240 1250 1260 IQSLGLNAGS EHSGRYRASV ESILIFNSMN QLNSLLQKEN LQDVFRKVEM PSQYCLALLE 1270 1280 1290 1300 1310 1320 LNGIGFSTAE CESQKHIMQA KLDAIETQAY QLAGHSFSFT SSDDIAEVLF LELKLPPNRE 1330 1340 1350 1360 1370 1380 MKNQGSKKTL GSTRRGIDNG RKLRLGRQFS TSKDVLNKLK ALHPLPGLIL EWRRITNAIT 1390 1400 1410 1420 1430 1440 KVVFPLQREK CLNPFLGMER IYPVSQSHTA TGRITFTEPN IQNVPRDFEI KMPTLVGESP 1450 1460 1470 1480 1490 1500 PSQAVGKGLL PMGRGKYKKG FSVNPRCQAQ MEERAADRGM PFSISMRHAF VPFPGGSILA 1510 1520 1530 1540 1550 1560 ADYSQLELRI LAHLSHDRRL IQVLNTGADV FRSIAAEWKM IEPESVGDDL RQQAKQICYG 1570 1580 1590 1600 1610 1620 IIYGMGAKSL GEQMGIKEND AACYIDSFKS RYTGINQFMT ETVKNCKRDG FVQTILGRRR 1630 1640 1650 1660 1670 1680 YLPGIKDNNP YRKAHAERQA INTIVQGSAA DIVKIATVNI QKQLETFHST FKSHGHREGM 1690 1700 1710 1720 1730 1740 LQSDQTGLSR KRKLQGMFCP IRGGFFILQL HDELLYEVAE EDVVQVAQIV KNEMESAVKL 1750 1760 SVKLKVKVKI GASWGELKDF DV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and chromosomal mapping of the human DNA polymerase theta (POLQ), the eighth human DNA polymerase." Sharief F.S., Vojta P.J., Ropp P.A., Copeland W.C. Genomics 59:90-96(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Spleen.
[2]	"POLQ (Pol theta), a DNA polymerase and DNA-dependent ATPase in human cells." Seki M., Marini F., Wood R.D. Nucleic Acids Res. 31:6117-6126(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
[3]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Catalytic activity of Pol eta, a new human DNA polymerase related to the bacterial DNA polymerase I family and Drosophila Mus308." Harris P.V., Kaelin C.B., Burtis K.C. Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1435-2590.
[5]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-990, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF052573 mRNA. Translation: AAC33565.1. AY338826 mRNA. Translation: AAR08421.2. AC069239 Genomic DNA. No translation available. AC079841 Genomic DNA. No translation available. AF043628 mRNA. Translation: AAD05272.1. Frameshift.
IPI	IPI00794779. IPI01012356.
RefSeq	NP_955452.3. NM_199420.3.
UniGene	Hs.241517.
3D structure databases
ProteinModelPortal	O75417.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000264233.
PTM databases
PhosphoSite	O75417.
Proteomic databases
PaxDb	O75417.
PRIDE	O75417.
Protocols and materials databases
DNASU	10721.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000264233; ENSP00000264233; ENSG00000051341.
GeneID	10721.
KEGG	hsa:10721.
UCSC	uc003eed.3. human. uc003eee.4. human.
Organism-specific databases
CTD	10721.
GeneCards	GC03M121150.
H-InvDB	HIX0030706.
HGNC	HGNC:9186. POLQ.
HPA	HPA048931.
MIM	604419. gene.
neXtProt	NX_O75417.
PharmGKB	PA33506.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1204.
HOGENOM	HOG000146444.
HOVERGEN	HBG005525.
KO	K02349.
OrthoDB	EOG42RD6C.
Gene expression databases
Bgee	O75417.
CleanEx	HS_POLH. HS_POLQ.
Genevestigator	O75417.
GermOnline	ENSG00000051341. Homo sapiens.
Family and domain databases
InterPro	IPR019760. DNA-dir_DNA_pol_A_CS. IPR001098. DNA-dir_DNA_pol_A_palm_dom. IPR011545. DNA/RNA_helicase_DEAD/DEAH_N. IPR002298. DNA_polymerase_A. IPR014001. Helicase_ATP-bd. IPR001650. Helicase_C. IPR012337. RNaseH-like_dom. [Graphical view]
Pfam	PF00270. DEAD. 1 hit. PF00476. DNA_pol_A. 1 hit. PF00271. Helicase_C. 1 hit. [Graphical view]
PRINTS	PR00868. DNAPOLI.
SMART	SM00487. DEXDc. 1 hit. SM00490. HELICc. 1 hit. SM00482. POLAc. 1 hit. [Graphical view]
SUPFAM	SSF53098. RNaseH_fold. 1 hit.
PROSITE	PS00447. DNA_POLYMERASE_A. 1 hit. PS51192. HELICASE_ATP_BIND_1. 1 hit. PS51194. HELICASE_CTER. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChEMBL	CHEMBL6025.
GenomeRNAi	10721.
NextBio	40701.
SOURCE	Search...

Entry information

Entry name

DPOLQ_HUMAN

Accession

Primary (citable) accession number: O75417
Secondary accession number(s): O95160, Q6VMB5

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	March 8, 2011
Last modified:	April 3, 2013
This is version 95 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.