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O75414 (NDK6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 129. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nucleoside diphosphate kinase 6

Short name=NDK 6
Short name=NDP kinase 6
EC=2.7.4.6
Alternative name(s):
Inhibitor of p53-induced apoptosis-alpha
Short name=IPIA-alpha
nm23-H6
Gene names
Name:NME6
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length186 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Inhibitor of p53-induced apoptosis.

Catalytic activity

ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.

Cofactor

Magnesium By similarity.

Tissue specificity

Expressed at a moderately low level in many tissues. Most abundant in kidney, prostate, ovary, intestine, and spleen.

Sequence similarities

Belongs to the NDK family.

Sequence caution

The sequence AAC69439.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAH01808.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAH12828.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAD96275.1 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O75414-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O75414-2)

The sequence of this isoform differs from the canonical sequence as follows:
     65-131: Missing.
Isoform 3 (identifier: O75414-3)

The sequence of this isoform differs from the canonical sequence as follows:
     65-186: GRFFYQRLVE...VAGTGGLGPA → AGQSEPTSLP...AIAQREVSTM

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 186186Nucleoside diphosphate kinase 6
PRO_0000137127

Sites

Active site1291Pros-phosphohistidine intermediate By similarity
Binding site191ATP By similarity
Binding site681ATP By similarity
Binding site961ATP By similarity
Binding site1021ATP By similarity
Binding site1161ATP By similarity
Binding site1261ATP By similarity

Natural variations

Alternative sequence65 – 186122GRFFY…GLGPA → AGQSEPTSLPTRMPSSSGGR SWDPPECSEHAMWPQILSVG VSASLTPATPPMVRTLWFQP AERLQPSSLTSVNSAGMRRK SPSCAVALCAIAQREVSTM in isoform 3.
VSP_036883
Alternative sequence65 – 13167Missing in isoform 2.
VSP_036882

Experimental info

Sequence conflict1821G → S in BAD96275. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 11, 2001. Version 3.
Checksum: DB8C5E046FACD143

FASTA18621,142
        10         20         30         40         50         60 
MASILRSPQA LQLTLALIKP DAVAHPLILE AVHQQILSNK FLIVRMRELL WRKEDCQRFY 

        70         80         90        100        110        120 
REHEGRFFYQ RLVEFMASGP IRAYILAHKD AIQLWRTLMG PTRVFRARHV APDSIRGSFG 

       130        140        150        160        170        180 
LTDTRNTTHG SDSVVSASRE IAAFFPDFSE QRWYEEEEPQ LRCGPVCYSP EGGVHYVAGT 


GGLGPA 

« Hide

Isoform 2 [UniParc].

Checksum: 57FB2BF44A5619F5
Show »

FASTA11913,510
Isoform 3 [UniParc].

Checksum: A27E767C901CC647
Show »

FASTA16318,087

References

« Hide 'large scale' references
[1]"NME6: a new member of the nm23/nucleoside diphosphate kinase gene family located on human chromosome 3p21.3."
Mehus J.G., Deloukas P., Lambeth D.O.
Hum. Genet. 104:454-459(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Liver.
[2]"Identification of a gene that inhibits p53-induced apoptosis."
Nakamura H., Tsuiki H., Honda Y., Sasaki J., Masuko N., Akagi K., Saya H.
Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
Tissue: Brain.
[4]Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Coronary artery.
[5]"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. expand/collapse author list , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Lymph.
[7]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF051941 mRNA. Translation: AAC78463.1.
U90449 mRNA. Translation: AAC69439.1. Different initiation.
AK294809 mRNA. Translation: BAG57928.1.
AK297364 mRNA. Translation: BAG59811.1.
AK222555 mRNA. Translation: BAD96275.1. Different initiation.
AC105267 Genomic DNA. No translation available.
BC001808 mRNA. Translation: AAH01808.1. Different initiation.
BC012828 mRNA. Translation: AAH12828.1. Different initiation.
RefSeqNP_005784.1. NM_005793.3.
XP_005264849.1. XM_005264792.1.
XP_005264851.1. XM_005264794.2.
UniGeneHs.465558.

3D structure databases

ProteinModelPortalO75414.
SMRO75414. Positions 14-146.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115496. 3 interactions.
IntActO75414. 2 interactions.
MINTMINT-4656535.
STRING9606.ENSP00000416658.

Proteomic databases

PaxDbO75414.
PRIDEO75414.

Protocols and materials databases

DNASU10201.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000415053; ENSP00000399582; ENSG00000172113. [O75414-1]
ENST00000415644; ENSP00000394232; ENSG00000172113. [O75414-2]
ENST00000421967; ENSP00000416658; ENSG00000172113.
ENST00000426689; ENSP00000440286; ENSG00000172113. [O75414-1]
ENST00000426723; ENSP00000391499; ENSG00000172113. [O75414-2]
ENST00000435684; ENSP00000393261; ENSG00000172113. [O75414-3]
ENST00000442597; ENSP00000406642; ENSG00000172113. [O75414-1]
ENST00000450160; ENSP00000398070; ENSG00000172113. [O75414-3]
ENST00000451657; ENSP00000407933; ENSG00000172113. [O75414-3]
ENST00000452211; ENSP00000392352; ENSG00000172113. [O75414-1]
GeneID10201.
KEGGhsa:10201.
UCSCuc003cso.3. human. [O75414-1]
uc010hju.4. human. [O75414-3]
uc011bbi.2. human. [O75414-2]

Organism-specific databases

CTD10201.
GeneCardsGC03M048334.
H-InvDBHIX0019874.
HGNCHGNC:20567. NME6.
HPAHPA017909.
MIM608294. gene.
neXtProtNX_O75414.
PharmGKBPA134873104.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0105.
HOGENOMHOG000224565.
HOVERGENHBG001619.
InParanoidO75414.
KOK00940.
OrthoDBEOG7QZGCP.
PhylomeDBO75414.
TreeFamTF354225.

Gene expression databases

ArrayExpressO75414.
BgeeO75414.
CleanExHS_NME6.
GenevestigatorO75414.

Family and domain databases

Gene3D3.30.70.141. 1 hit.
InterProIPR001564. Nucleoside_diP_kinase.
IPR023005. Nucleoside_diP_kinase_AS.
[Graphical view]
PfamPF00334. NDK. 1 hit.
[Graphical view]
PRINTSPR01243. NUCDPKINASE.
SMARTSM00562. NDK. 1 hit.
[Graphical view]
SUPFAMSSF54919. SSF54919. 1 hit.
PROSITEPS00469. NDP_KINASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi10201.
NextBio38610.
PROO75414.
SOURCESearch...

Entry information

Entry nameNDK6_HUMAN
AccessionPrimary (citable) accession number: O75414
Secondary accession number(s): B4DGW7 expand/collapse secondary AC list , B4DM99, Q53HM5, Q96E73, Q9BQ63
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 11, 2001
Last modified: April 16, 2014
This is version 129 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM