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Protein

Nucleoside diphosphate kinase 6

Gene

NME6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Inhibitor of p53-induced apoptosis.

Catalytic activityi

ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.PROSITE-ProRule annotation

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei19ATPBy similarity1
Binding sitei68ATPBy similarity1
Binding sitei96ATPBy similarity1
Binding sitei102ATPBy similarity1
Binding sitei116ATPBy similarity1
Binding sitei126ATPBy similarity1
Active sitei129Pros-phosphohistidine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • nucleoside diphosphate kinase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processApoptosis, Nucleotide metabolism
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-499943. Interconversion of nucleotide di- and triphosphates.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoside diphosphate kinase 6 (EC:2.7.4.6)
Short name:
NDK 6
Short name:
NDP kinase 6
Alternative name(s):
Inhibitor of p53-induced apoptosis-alpha
Short name:
IPIA-alpha
nm23-H6
Gene namesi
Name:NME6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000172113.8.
HGNCiHGNC:20567. NME6.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi10201.
OpenTargetsiENSG00000172113.
PharmGKBiPA134873104.

Polymorphism and mutation databases

BioMutaiNME6.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001371271 – 186Nucleoside diphosphate kinase 6Add BLAST186

Proteomic databases

EPDiO75414.
MaxQBiO75414.
PaxDbiO75414.
PeptideAtlasiO75414.
PRIDEiO75414.

Expressioni

Tissue specificityi

Expressed at a moderately low level in many tissues. Most abundant in kidney, prostate, ovary, intestine, and spleen.

Gene expression databases

BgeeiENSG00000172113.
CleanExiHS_NME6.
ExpressionAtlasiO75414. baseline and differential.
GenevisibleiO75414. HS.

Organism-specific databases

HPAiHPA017909.

Interactioni

Protein-protein interaction databases

BioGridi115496. 14 interactors.
IntActiO75414. 2 interactors.
MINTiMINT-4656535.
STRINGi9606.ENSP00000416658.

Structurei

3D structure databases

ProteinModelPortaliO75414.
SMRiO75414.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NDK family.Curated

Phylogenomic databases

eggNOGiKOG0888. Eukaryota.
COG0105. LUCA.
GeneTreeiENSGT00760000119146.
HOGENOMiHOG000224565.
HOVERGENiHBG001619.
InParanoidiO75414.
KOiK00940.
PhylomeDBiO75414.
TreeFamiTF354225.

Family and domain databases

Gene3Di3.30.70.141. 1 hit.
InterProiView protein in InterPro
IPR034907. NDK-like_dom.
IPR001564. Nucleoside_diP_kinase.
IPR023005. Nucleoside_diP_kinase_AS.
PfamiView protein in Pfam
PF00334. NDK. 1 hit.
PRINTSiPR01243. NUCDPKINASE.
SMARTiView protein in SMART
SM00562. NDK. 1 hit.
SUPFAMiSSF54919. SSF54919. 1 hit.
PROSITEiView protein in PROSITE
PS00469. NDP_KINASES. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75414-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASILRSPQA LQLTLALIKP DAVAHPLILE AVHQQILSNK FLIVRMRELL
60 70 80 90 100
WRKEDCQRFY REHEGRFFYQ RLVEFMASGP IRAYILAHKD AIQLWRTLMG
110 120 130 140 150
PTRVFRARHV APDSIRGSFG LTDTRNTTHG SDSVVSASRE IAAFFPDFSE
160 170 180
QRWYEEEEPQ LRCGPVCYSP EGGVHYVAGT GGLGPA
Length:186
Mass (Da):21,142
Last modified:January 11, 2001 - v3
Checksum:iDB8C5E046FACD143
GO
Isoform 2 (identifier: O75414-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     65-131: Missing.

Show »
Length:119
Mass (Da):13,510
Checksum:i57FB2BF44A5619F5
GO
Isoform 3 (identifier: O75414-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     65-186: GRFFYQRLVE...VAGTGGLGPA → AGQSEPTSLP...AIAQREVSTM

Show »
Length:163
Mass (Da):18,087
Checksum:iA27E767C901CC647
GO

Sequence cautioni

The sequence AAC69439 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH01808 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH12828 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAD96275 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti182G → S in BAD96275 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03688365 – 186GRFFY…GLGPA → AGQSEPTSLPTRMPSSSGGR SWDPPECSEHAMWPQILSVG VSASLTPATPPMVRTLWFQP AERLQPSSLTSVNSAGMRRK SPSCAVALCAIAQREVSTM in isoform 3. 1 PublicationAdd BLAST122
Alternative sequenceiVSP_03688265 – 131Missing in isoform 2. 1 PublicationAdd BLAST67

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF051941 mRNA. Translation: AAC78463.1.
U90449 mRNA. Translation: AAC69439.1. Different initiation.
AK294809 mRNA. Translation: BAG57928.1.
AK297364 mRNA. Translation: BAG59811.1.
AK222555 mRNA. Translation: BAD96275.1. Different initiation.
AC105267 Genomic DNA. No translation available.
BC001808 mRNA. Translation: AAH01808.1. Different initiation.
BC012828 mRNA. Translation: AAH12828.1. Different initiation.
CCDSiCCDS77733.1. [O75414-3]
CCDS77734.1. [O75414-1]
CCDS82768.1. [O75414-2]
RefSeqiNP_001295355.1. NM_001308426.1. [O75414-1]
NP_001295356.1. NM_001308427.1. [O75414-1]
NP_001295357.1. NM_001308428.1. [O75414-1]
NP_001295360.1. NM_001308431.1. [O75414-3]
NP_001295362.1. NM_001308433.1. [O75414-3]
NP_001295364.1. NM_001308435.1. [O75414-2]
NP_005784.1. NM_005793.4.
XP_016861003.1. XM_017005514.1. [O75414-1]
XP_016861004.1. XM_017005515.1. [O75414-3]
UniGeneiHs.465558.
Hs.638192.

Genome annotation databases

EnsembliENST00000415053; ENSP00000399582; ENSG00000172113. [O75414-1]
ENST00000415644; ENSP00000394232; ENSG00000172113. [O75414-2]
ENST00000426689; ENSP00000440286; ENSG00000172113. [O75414-1]
ENST00000435684; ENSP00000393261; ENSG00000172113. [O75414-3]
ENST00000442597; ENSP00000406642; ENSG00000172113. [O75414-1]
ENST00000451657; ENSP00000407933; ENSG00000172113. [O75414-3]
ENST00000452211; ENSP00000392352; ENSG00000172113. [O75414-1]
GeneIDi10201.
KEGGihsa:10201.
UCSCiuc003cso.4. human. [O75414-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiNDK6_HUMAN
AccessioniPrimary (citable) accession number: O75414
Secondary accession number(s): B4DGW7
, B4DM99, Q53HM5, Q96E73, Q9BQ63
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 11, 2001
Last modified: September 27, 2017
This is version 156 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families