Reviewed,
UniProtKB/Swiss-Prot O75414 (NDK6_HUMAN)
Last modified
January 19, 2010.
Version 91.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Nucleoside diphosphate kinase 6 Short name=NDP kinase 6 Short name=NDK 6 EC=2.7.4.6 Alternative name(s): nm23-H6 Inhibitor of p53-induced apoptosis-alpha Short name=IPIA-alpha | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) [Complete proteome] | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 186 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Inhibitor of p53-induced apoptosis. |
| Catalytic activity | ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. |
| Cofactor | Magnesium By similarity. |
| Tissue specificity | Expressed at a moderately low level in many tissues. Most abundant in kidney, prostate, ovary, intestine, and spleen. |
| Sequence similarities | Belongs to the NDK family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Apoptosis Nucleotide metabolism |
| Coding sequence diversity | Alternative splicing |
| Ligand | ATP-binding Magnesium Metal-binding Nucleotide-binding |
| Molecular function | Kinase Transferase |
| PTM | Phosphoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | CTP biosynthetic process Inferred from electronic annotation. Source: InterPro GTP biosynthetic processInferred from electronic annotation. Source: InterPro UTP biosynthetic processInferred from electronic annotation. Source: InterPro anti-apoptosisNon-traceable author statement. Source: UniProtKB apoptosisInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | ATP binding Non-traceable author statement. Source: UniProtKB magnesium ion bindingInferred from electronic annotation. Source: UniProtKB-KW nucleoside diphosphate kinase activityTraceable author statement. Source: UniProtKB |
| Complete GO annotation... | |
Alternative products
| This entry describes 3 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: O75414-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: O75414-2) The sequence of this isoform differs from the canonical sequence as follows: 65-131: Missing. | ||||||
| Isoform 3 (identifier: O75414-3) The sequence of this isoform differs from the canonical sequence as follows: 65-186: GRFFYQRLVE...VAGTGGLGPA → AGQSEPTSLP...AIAQREVSTM |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 186 | 186 | Nucleoside diphosphate kinase 6 | PRO_0000137127 | |||||
Sites | |||||||||
| Active site | 129 | 1 | Pros-phosphohistidine intermediate By similarity | ||||||
| Binding site | 19 | 1 | ATP By similarity | ||||||
| Binding site | 68 | 1 | ATP By similarity | ||||||
| Binding site | 96 | 1 | ATP By similarity | ||||||
| Binding site | 102 | 1 | ATP By similarity | ||||||
| Binding site | 116 | 1 | ATP By similarity | ||||||
| Binding site | 126 | 1 | ATP By similarity | ||||||
Natural variations | |||||||||
| Alternative sequence | 65 – 186 | 122 | GRFFY…GLGPA → AGQSEPTSLPTRMPSSSGGR SWDPPECSEHAMWPQILSVG VSASLTPATPPMVRTLWFQP AERLQPSSLTSVNSAGMRRK SPSCAVALCAIAQREVSTM in isoform 3. | VSP_036883 | |||||
| Alternative sequence | 65 – 131 | 67 | Missing in isoform 2. | VSP_036882 | |||||
Experimental info | |||||||||
| Sequence conflict | 182 | 1 | G → S in BAD96275. Ref.3 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "NME6: a new member of the nm23/nucleoside diphosphate kinase gene family located on human chromosome 3p21.3." Mehus J.G., Deloukas P., Lambeth D.O. Hum. Genet. 104:454-459(1999) [PubMed: 10453732] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Liver. |
| [2] | "Identification of a gene that inhibits p53-induced apoptosis." Nakamura H., Tsuiki H., Honda Y., Sasaki J., Masuko N., Akagi K., Saya H. Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). |
| [3] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Tissue: Brain. |
| [4] | Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Coronary artery. |
| [5] | "The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. Gibbs R.A.Nature 440:1194-1198(2006) [PubMed: 16641997] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [6] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Lymph. |
| [7] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF051941 mRNA. Translation: AAC78463.1. U90449 mRNA. Translation: AAC69439.1. Different initiation. AK294809 mRNA. Translation: BAG57928.1. AK297364 mRNA. Translation: BAG59811.1. AK222555 mRNA. Translation: BAD96275.1. Different initiation. AC105267 Genomic DNA. No translation available. BC001808 mRNA. Translation: AAH01808.1. Different initiation. BC012828 mRNA. Translation: AAH12828.1. Different initiation. |
| IPI | IPI00910570. IPI00910598. IPI00925914. |
| RefSeq | NP_005784.1. |
| UniGene | Hs.465558 |
3D structure databases | |
| SMR | O75414. Positions 11-161. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | O75414. |
Genome annotation databases | |
| Ensembl | ENST00000415053; ENSP00000399582; ENSG00000172113; Homo sapiens. [Genome view] ENST00000421967; ENSP00000416658; ENSG00000172113; Homo sapiens. [Genome view] ENST00000442597; ENSP00000406642; ENSG00000172113; Homo sapiens. [Genome view] ENST00000452211; ENSP00000392352; ENSG00000172113; Homo sapiens. [Genome view] |
| GeneID | 10201. |
| KEGG | hsa:10201. |
| UCSC | uc003cso.1. human. |
Organism-specific databases | |
| CTD | 10201. |
| GeneCards | GC03M048311. |
| H-InvDB | HIX0019874. |
| HGNC | HGNC:20567. NME6. |
| MIM | 608294. gene. |
| PharmGKB | PA134873104. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG08837. |
| HOGENOM | HBG445152. |
| HOVERGEN | O75414. |
| InParanoid | O75414. |
| OrthoDB | EOG98PQ55. |
Enzyme and pathway databases | |
| BRENDA | 2.7.4.6. 247. |
Gene expression databases | |
| ArrayExpress | O75414. |
| Bgee | O75414. |
| CleanEx | HS_NME6. |
| Genevestigator | O75414. |
| GermOnline | ENSG00000172113. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR001564. Nuc_diP_kinase_core. [Graphical view] |
| Gene3D | G3DSA:3.30.70.141. NDK. 1 hit. |
| PANTHER | PTHR11349. Nuc_diP_kinase_core. 1 hit. |
| Pfam | PF00334. NDK. 1 hit. [Graphical view] |
| PRINTS | PR01243. NUCDPKINASE. |
| SMART | SM00562. NDK. 1 hit. [Graphical view] |
| PROSITE | PS00469. NDP_KINASES. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 38610. |
| SOURCE | Search... |
Entry information
| Entry name | NDK6_HUMAN | ||||||||
| Accession | Primary (citable) accession number: O75414 Secondary accession number(s): B4DGW7 Q9BQ63 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 3 Human chromosome 3: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

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