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O75414

- NDK6_HUMAN

UniProt

O75414 - NDK6_HUMAN

Protein

Nucleoside diphosphate kinase 6

Gene

NME6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 131 (01 Oct 2014)
      Sequence version 3 (11 Jan 2001)
      Previous versions | rss
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    Functioni

    Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Inhibitor of p53-induced apoptosis.

    Catalytic activityi

    ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.PROSITE-ProRule annotation

    Cofactori

    Magnesium.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei19 – 191ATPBy similarity
    Binding sitei68 – 681ATPBy similarity
    Binding sitei96 – 961ATPBy similarity
    Binding sitei102 – 1021ATPBy similarity
    Binding sitei116 – 1161ATPBy similarity
    Binding sitei126 – 1261ATPBy similarity
    Active sitei129 – 1291Pros-phosphohistidine intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. nucleoside diphosphate kinase activity Source: UniProtKB

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. CTP biosynthetic process Source: InterPro
    3. GTP biosynthetic process Source: InterPro
    4. negative regulation of cell growth Source: UniProtKB
    5. negative regulation of mitosis Source: UniProtKB
    6. UTP biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Apoptosis, Nucleotide metabolism

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nucleoside diphosphate kinase 6 (EC:2.7.4.6)
    Short name:
    NDK 6
    Short name:
    NDP kinase 6
    Alternative name(s):
    Inhibitor of p53-induced apoptosis-alpha
    Short name:
    IPIA-alpha
    nm23-H6
    Gene namesi
    Name:NME6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:20567. NME6.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134873104.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 186186Nucleoside diphosphate kinase 6PRO_0000137127Add
    BLAST

    Proteomic databases

    MaxQBiO75414.
    PaxDbiO75414.
    PRIDEiO75414.

    Expressioni

    Tissue specificityi

    Expressed at a moderately low level in many tissues. Most abundant in kidney, prostate, ovary, intestine, and spleen.

    Gene expression databases

    ArrayExpressiO75414.
    BgeeiO75414.
    CleanExiHS_NME6.
    GenevestigatoriO75414.

    Organism-specific databases

    HPAiHPA017909.

    Interactioni

    Protein-protein interaction databases

    BioGridi115496. 3 interactions.
    IntActiO75414. 2 interactions.
    MINTiMINT-4656535.
    STRINGi9606.ENSP00000416658.

    Structurei

    3D structure databases

    ProteinModelPortaliO75414.
    SMRiO75414. Positions 14-146.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NDK family.Curated

    Phylogenomic databases

    eggNOGiCOG0105.
    HOGENOMiHOG000224565.
    HOVERGENiHBG001619.
    InParanoidiO75414.
    KOiK00940.
    OrthoDBiEOG7QZGCP.
    PhylomeDBiO75414.
    TreeFamiTF354225.

    Family and domain databases

    Gene3Di3.30.70.141. 1 hit.
    InterProiIPR001564. Nucleoside_diP_kinase.
    IPR023005. Nucleoside_diP_kinase_AS.
    [Graphical view]
    PfamiPF00334. NDK. 1 hit.
    [Graphical view]
    PRINTSiPR01243. NUCDPKINASE.
    SMARTiSM00562. NDK. 1 hit.
    [Graphical view]
    SUPFAMiSSF54919. SSF54919. 1 hit.
    PROSITEiPS00469. NDP_KINASES. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O75414-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MASILRSPQA LQLTLALIKP DAVAHPLILE AVHQQILSNK FLIVRMRELL    50
    WRKEDCQRFY REHEGRFFYQ RLVEFMASGP IRAYILAHKD AIQLWRTLMG 100
    PTRVFRARHV APDSIRGSFG LTDTRNTTHG SDSVVSASRE IAAFFPDFSE 150
    QRWYEEEEPQ LRCGPVCYSP EGGVHYVAGT GGLGPA 186
    Length:186
    Mass (Da):21,142
    Last modified:January 11, 2001 - v3
    Checksum:iDB8C5E046FACD143
    GO
    Isoform 2 (identifier: O75414-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         65-131: Missing.

    Show »
    Length:119
    Mass (Da):13,510
    Checksum:i57FB2BF44A5619F5
    GO
    Isoform 3 (identifier: O75414-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         65-186: GRFFYQRLVE...VAGTGGLGPA → AGQSEPTSLP...AIAQREVSTM

    Show »
    Length:163
    Mass (Da):18,087
    Checksum:iA27E767C901CC647
    GO

    Sequence cautioni

    The sequence AAC69439.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAH01808.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAH12828.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAD96275.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti182 – 1821G → S in BAD96275. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei65 – 186122GRFFY…GLGPA → AGQSEPTSLPTRMPSSSGGR SWDPPECSEHAMWPQILSVG VSASLTPATPPMVRTLWFQP AERLQPSSLTSVNSAGMRRK SPSCAVALCAIAQREVSTM in isoform 3. 1 PublicationVSP_036883Add
    BLAST
    Alternative sequencei65 – 13167Missing in isoform 2. 1 PublicationVSP_036882Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF051941 mRNA. Translation: AAC78463.1.
    U90449 mRNA. Translation: AAC69439.1. Different initiation.
    AK294809 mRNA. Translation: BAG57928.1.
    AK297364 mRNA. Translation: BAG59811.1.
    AK222555 mRNA. Translation: BAD96275.1. Different initiation.
    AC105267 Genomic DNA. No translation available.
    BC001808 mRNA. Translation: AAH01808.1. Different initiation.
    BC012828 mRNA. Translation: AAH12828.1. Different initiation.
    RefSeqiNP_005784.1. NM_005793.3.
    XP_005264849.1. XM_005264792.1. [O75414-1]
    XP_005264851.1. XM_005264794.2. [O75414-3]
    UniGeneiHs.465558.

    Genome annotation databases

    EnsembliENST00000415053; ENSP00000399582; ENSG00000172113. [O75414-1]
    ENST00000415644; ENSP00000394232; ENSG00000172113. [O75414-2]
    ENST00000421967; ENSP00000416658; ENSG00000172113.
    ENST00000426689; ENSP00000440286; ENSG00000172113. [O75414-1]
    ENST00000435684; ENSP00000393261; ENSG00000172113. [O75414-3]
    ENST00000442597; ENSP00000406642; ENSG00000172113. [O75414-1]
    ENST00000451657; ENSP00000407933; ENSG00000172113. [O75414-3]
    ENST00000452211; ENSP00000392352; ENSG00000172113. [O75414-1]
    GeneIDi10201.
    KEGGihsa:10201.
    UCSCiuc003cso.3. human. [O75414-1]
    uc010hju.4. human. [O75414-3]
    uc011bbi.2. human. [O75414-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF051941 mRNA. Translation: AAC78463.1 .
    U90449 mRNA. Translation: AAC69439.1 . Different initiation.
    AK294809 mRNA. Translation: BAG57928.1 .
    AK297364 mRNA. Translation: BAG59811.1 .
    AK222555 mRNA. Translation: BAD96275.1 . Different initiation.
    AC105267 Genomic DNA. No translation available.
    BC001808 mRNA. Translation: AAH01808.1 . Different initiation.
    BC012828 mRNA. Translation: AAH12828.1 . Different initiation.
    RefSeqi NP_005784.1. NM_005793.3.
    XP_005264849.1. XM_005264792.1. [O75414-1 ]
    XP_005264851.1. XM_005264794.2. [O75414-3 ]
    UniGenei Hs.465558.

    3D structure databases

    ProteinModelPortali O75414.
    SMRi O75414. Positions 14-146.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115496. 3 interactions.
    IntActi O75414. 2 interactions.
    MINTi MINT-4656535.
    STRINGi 9606.ENSP00000416658.

    Proteomic databases

    MaxQBi O75414.
    PaxDbi O75414.
    PRIDEi O75414.

    Protocols and materials databases

    DNASUi 10201.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000415053 ; ENSP00000399582 ; ENSG00000172113 . [O75414-1 ]
    ENST00000415644 ; ENSP00000394232 ; ENSG00000172113 . [O75414-2 ]
    ENST00000421967 ; ENSP00000416658 ; ENSG00000172113 .
    ENST00000426689 ; ENSP00000440286 ; ENSG00000172113 . [O75414-1 ]
    ENST00000435684 ; ENSP00000393261 ; ENSG00000172113 . [O75414-3 ]
    ENST00000442597 ; ENSP00000406642 ; ENSG00000172113 . [O75414-1 ]
    ENST00000451657 ; ENSP00000407933 ; ENSG00000172113 . [O75414-3 ]
    ENST00000452211 ; ENSP00000392352 ; ENSG00000172113 . [O75414-1 ]
    GeneIDi 10201.
    KEGGi hsa:10201.
    UCSCi uc003cso.3. human. [O75414-1 ]
    uc010hju.4. human. [O75414-3 ]
    uc011bbi.2. human. [O75414-2 ]

    Organism-specific databases

    CTDi 10201.
    GeneCardsi GC03M048334.
    H-InvDB HIX0019874.
    HGNCi HGNC:20567. NME6.
    HPAi HPA017909.
    MIMi 608294. gene.
    neXtProti NX_O75414.
    PharmGKBi PA134873104.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0105.
    HOGENOMi HOG000224565.
    HOVERGENi HBG001619.
    InParanoidi O75414.
    KOi K00940.
    OrthoDBi EOG7QZGCP.
    PhylomeDBi O75414.
    TreeFami TF354225.

    Miscellaneous databases

    GenomeRNAii 10201.
    NextBioi 38610.
    PROi O75414.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O75414.
    Bgeei O75414.
    CleanExi HS_NME6.
    Genevestigatori O75414.

    Family and domain databases

    Gene3Di 3.30.70.141. 1 hit.
    InterProi IPR001564. Nucleoside_diP_kinase.
    IPR023005. Nucleoside_diP_kinase_AS.
    [Graphical view ]
    Pfami PF00334. NDK. 1 hit.
    [Graphical view ]
    PRINTSi PR01243. NUCDPKINASE.
    SMARTi SM00562. NDK. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54919. SSF54919. 1 hit.
    PROSITEi PS00469. NDP_KINASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "NME6: a new member of the nm23/nucleoside diphosphate kinase gene family located on human chromosome 3p21.3."
      Mehus J.G., Deloukas P., Lambeth D.O.
      Hum. Genet. 104:454-459(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Liver.
    2. "Identification of a gene that inhibits p53-induced apoptosis."
      Nakamura H., Tsuiki H., Honda Y., Sasaki J., Masuko N., Akagi K., Saya H.
      Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Tissue: Brain.
    4. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Coronary artery.
    5. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lymph.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiNDK6_HUMAN
    AccessioniPrimary (citable) accession number: O75414
    Secondary accession number(s): B4DGW7
    , B4DM99, Q53HM5, Q96E73, Q9BQ63
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: January 11, 2001
    Last modified: October 1, 2014
    This is version 131 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3