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Protein

Transforming acidic coiled-coil-containing protein 1

Gene

TACC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Likely involved in the processes that promote cell division prior to the formation of differentiated tissues.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Enzyme and pathway databases

BioCyciZFISH:ENSG00000147526-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transforming acidic coiled-coil-containing protein 1
Alternative name(s):
Gastric cancer antigen Ga55
Taxin-1
Gene namesi
Name:TACC1
Synonyms:KIAA1103
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:11522. TACC1.

Subcellular locationi

Isoform 5 :

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi228S → A: Impairs phosphorylation by AURKC. 1 Publication1

Organism-specific databases

DisGeNETi6867.
MalaCardsiTACC1.
OpenTargetsiENSG00000147526.
Orphaneti251579. Giant cell glioblastoma.
251576. Gliosarcoma.
PharmGKBiPA36299.

Polymorphism and mutation databases

BioMutaiTACC1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001799862 – 805Transforming acidic coiled-coil-containing protein 1Add BLAST804
Isoform 5 (identifier: O75410-5)
Initiator methionineiRemoved1 Publication

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei4PhosphoserineCombined sources1
Modified residuei10PhosphoserineCombined sources1
Modified residuei44PhosphoserineCombined sources1
Modified residuei147PhosphoserineCombined sources1
Modified residuei153PhosphoserineCombined sources1
Modified residuei228Phosphoserine; by AURKC1 Publication1
Modified residuei248PhosphoserineCombined sources1
Modified residuei276PhosphoserineCombined sources1
Modified residuei381PhosphoserineBy similarity1
Modified residuei406PhosphoserineBy similarity1
Modified residuei483PhosphoserineBy similarity1
Modified residuei533PhosphotyrosineCombined sources1
Modified residuei591PhosphoserineCombined sources1
Isoform 5 (identifier: O75410-5)
Lipidationi2N-myristoyl glycine1 Publication1

Post-translational modificationi

Isoform 1 is heavily phosphorylated; isoform 6 is not.2 Publications

Keywords - PTMi

Acetylation, Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDiO75410.
MaxQBiO75410.
PaxDbiO75410.
PeptideAtlasiO75410.
PRIDEiO75410.

PTM databases

iPTMnetiO75410.
PhosphoSitePlusiO75410.

Miscellaneous databases

PMAP-CutDBO75410.

Expressioni

Tissue specificityi

Isoform 1, isoform 3 and isoform 5 are ubiquitous. Isoform 2 is strongly expressed in the brain, weakly detectable in lung and colon, and overexpressed in gastric cancer. Isoform 4 is not detected in normal tissues, but strong expression was found in gastric cancer tissues. Down-regulated in a subset of cases of breast cancer.2 Publications

Developmental stagei

Expressed at high level during early embryogenesis.

Gene expression databases

BgeeiENSG00000147526.
ExpressionAtlasiO75410. baseline and differential.
GenevisibleiO75410. HS.

Organism-specific databases

HPAiCAB017041.
HPA024702.

Interactioni

Subunit structurei

Interacts with KIAA0097/CH-TOG and with the oncogenic transcription factor YEATS4. Interacts with AURKA, AURKB and AURKC. Interacts with LSM7, TDRD7 and SNRPG. Interacts with GCN5L2 and PCAF.6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
AURKBQ96GD42EBI-624278,EBI-624291
BTRCQ9Y2973EBI-624237,EBI-307461
CKAP5Q140084EBI-624237,EBI-310585
HTTP428584EBI-624237,EBI-466029
LSM7Q9UK454EBI-624252,EBI-348372
MEMO1Q9Y3164EBI-624237,EBI-1104564
SH2D4AQ9H7883EBI-624237,EBI-747035
SNRPGP623085EBI-624252,EBI-624585
STX5Q131903EBI-624237,EBI-714206
TDRD7Q8NHU64EBI-624237,EBI-624505
THAP12O434223EBI-624237,EBI-2828217
YEATS4O956196EBI-624237,EBI-399269

Protein-protein interaction databases

BioGridi112730. 38 interactors.
IntActiO75410. 31 interactors.
MINTiMINT-8417725.
STRINGi9606.ENSP00000321703.

Structurei

3D structure databases

ProteinModelPortaliO75410.
SMRiO75410.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini215 – 297SPAZ 1Add BLAST83
Domaini359 – 507SPAZ 2Add BLAST149

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 55Interaction with LSM7 and SNRPG1 PublicationAdd BLAST54
Regioni152 – 259Interaction with TDRD71 PublicationAdd BLAST108
Regioni206 – 427Interaction with YEATS41 PublicationAdd BLAST222
Regioni701 – 805Interaction with CH-TOGAdd BLAST105

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili610 – 805Add BLAST196

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi226 – 241Bipartite nuclear localization signal 1Sequence analysisAdd BLAST16
Motifi455 – 471Bipartite nuclear localization signal 2Sequence analysisAdd BLAST17

Sequence similaritiesi

Belongs to the TACC family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410IIVK. Eukaryota.
ENOG410YMFS. LUCA.
GeneTreeiENSGT00530000063855.
HOVERGENiHBG105967.
InParanoidiO75410.
KOiK14281.
OMAiDTNDSGV.
OrthoDBiEOG091G072Z.
PhylomeDBiO75410.
TreeFamiTF333149.

Family and domain databases

InterProiIPR007707. TACC.
[Graphical view]
PfamiPF05010. TACC. 1 hit.
[Graphical view]

Sequences (8)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 8 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: O75410-1) [UniParc]FASTAAdd to basket
Also known as: A, Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAFSPWQILS PVQWAKWTWS AVRGGAAGED EAGGPEGDPE EEDSQAETKS
60 70 80 90 100
LSFSSDSEGN FETPEAETPI RSPFKESCDP SLGLAGPGAK SQESQEADEQ
110 120 130 140 150
LVAEVVEKCS SKTCSKPSEN EVPQQAIDSH SVKNFREEPE HDFSKISIVR
160 170 180 190 200
PFSIETKDST DISAVLGTKA AHGCVTAVSG KALPSSPPDA LQDEAMTEGS
210 220 230 240 250
MGVTLEASAE ADLKAGNSCP ELVPSRRSKL RKPKPVPLRK KAIGGEFSDT
260 270 280 290 300
NAAVEGTPLP KASYHFSPEE LDENTSPLLG DARFQKSPPD LKETPGTLSS
310 320 330 340 350
DTNDSGVELG EESRSSPLKL EFDFTEDTGN IEARKALPRK LGRKLGSTLT
360 370 380 390 400
PKIQKDGISK SAGLEQPTDP VARDGPLSQT SSKPDPSQWE SPSFNPFGSH
410 420 430 440 450
SVLQNSPPLS SEGSYHFDPD NFDESMDPFK PTTTLTSSDF CSPTGNHVNE
460 470 480 490 500
ILESPKKAKS RLITSGCKVK KHETQSLALD ACSRDEGAVI SQISDISNRD
510 520 530 540 550
GHATDEEKLA STSCGQKSAG AEVKGEPEED LEYFECSNVP VSTINHAFSS
560 570 580 590 600
SEAGIEKETC QKMEEDGSTV LGLLESSAEK APVSVSCGGE SPLDGICLSE
610 620 630 640 650
SDKTAVLTLI REEIITKEIE ANEWKKKYEE TRQEVLEMRK IVAEYEKTIA
660 670 680 690 700
QMIEDEQRTS MTSQKSFQQL TMEKEQALAD LNSVERSLSD LFRRYENLKG
710 720 730 740 750
VLEGFKKNEE ALKKCAQDYL ARVKQEEQRY QALKIHAEEK LDKANEEIAQ
760 770 780 790 800
VRTKAKAESA ALHAGLRKEQ MKVESLERAL QQKNQEIEEL TKICDELIAK

LGKTD
Length:805
Mass (Da):87,794
Last modified:February 1, 2005 - v2
Checksum:i3A261EF58C165107
GO
Isoform 2 (identifier: O75410-2) [UniParc]FASTAAdd to basket
Also known as: F

The sequence of this isoform differs from the canonical sequence as follows:
     464-464: T → TTTEQVKFLCFLL

Show »
Length:817
Mass (Da):89,218
Checksum:iB9D4BDE7B742E813
GO
Isoform 3 (identifier: O75410-3) [UniParc]FASTAAdd to basket
Also known as: E

The sequence of this isoform differs from the canonical sequence as follows:
     1-195: Missing.

Show »
Length:610
Mass (Da):67,073
Checksum:i802527D4B613A881
GO
Isoform 4 (identifier: O75410-4) [UniParc]FASTAAdd to basket
Also known as: D

The sequence of this isoform differs from the canonical sequence as follows:
     1-426: Missing.
     427-464: DPFKPTTTLT...PKKAKSRLIT → MGGSHSQTPR...EQVKFLCFLL

Show »
Length:379
Mass (Da):42,326
Checksum:iA3CF1029DF65E860
GO
Isoform 5 (identifier: O75410-5) [UniParc]FASTAAdd to basket
Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     1-438: Missing.
     439-464: DFCSPTGNHVNEILESPKKAKSRLIT → MGGSHSQTPRGREPAGERHPRPTETA

Show »
Length:367
Mass (Da):40,903
Checksum:iF1761EA28D5AB9A8
GO
Isoform 6 (identifier: O75410-6) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     54-54: S → R
     55-464: Missing.

Show »
Length:395
Mass (Da):43,984
Checksum:iB29F0EA1DCAAF8E1
GO
Isoform 7 (identifier: O75410-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-41: Missing.
     42-53: EDSQAETKSLSF → MNNILKLK
     525-553: Missing.

Show »
Length:731
Mass (Da):79,872
Checksum:i385263AECC0C7060
GO
Isoform 8 (identifier: O75410-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-651: Missing.

Show »
Length:154
Mass (Da):17,815
Checksum:iF7CF945C5A3E277D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti291L → I in AAC32327 (PubMed:10435627).Curated1
Sequence conflicti428P → H in AAH41391 (PubMed:15489334).Curated1
Sequence conflicti588G → V in BAA83055 (PubMed:10470851).Curated1
Sequence conflicti654Missing in BAA83055 (PubMed:10470851).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053703187P → L.Corresponds to variant rs34235313dbSNPEnsembl.1
Natural variantiVAR_053704243I → T.Corresponds to variant rs6980553dbSNPEnsembl.1
Natural variantiVAR_053705255E → G.Corresponds to variant rs10107016dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0126401 – 651Missing in isoform 8. 1 PublicationAdd BLAST651
Alternative sequenceiVSP_0126391 – 438Missing in isoform 5. CuratedAdd BLAST438
Alternative sequenceiVSP_0126411 – 426Missing in isoform 4. CuratedAdd BLAST426
Alternative sequenceiVSP_0126381 – 195Missing in isoform 3. 1 PublicationAdd BLAST195
Alternative sequenceiVSP_0126371 – 41Missing in isoform 7. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_01264342 – 53EDSQA…KSLSF → MNNILKLK in isoform 7. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_01264454S → R in isoform 6. 1 Publication1
Alternative sequenceiVSP_01264555 – 464Missing in isoform 6. 1 PublicationAdd BLAST410
Alternative sequenceiVSP_012642427 – 464DPFKP…SRLIT → MGGSHSQTPRGREPAGERHP RPTETATTEQVKFLCFLL in isoform 4. CuratedAdd BLAST38
Alternative sequenceiVSP_012646439 – 464DFCSP…SRLIT → MGGSHSQTPRGREPAGERHP RPTETA in isoform 5. CuratedAdd BLAST26
Alternative sequenceiVSP_012647464T → TTTEQVKFLCFLL in isoform 2. 2 Publications1
Alternative sequenceiVSP_012648525 – 553Missing in isoform 7. 1 PublicationAdd BLAST29

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF049910 mRNA. Translation: AAC32327.1.
AY177411 mRNA. Translation: AAO53446.1.
AY139007 mRNA. Translation: AAN28955.1.
AK314620 mRNA. Translation: BAG37186.1.
CH471080 Genomic DNA. Translation: EAW63293.1.
CH471080 Genomic DNA. Translation: EAW63296.1.
CH471080 Genomic DNA. Translation: EAW63298.1.
BC041391 mRNA. Translation: AAH41391.1.
AB029026 mRNA. Translation: BAA83055.1.
AY039239 mRNA. Translation: AAK68658.1.
AY072874 mRNA. Translation: AAL62461.1.
AY072875 mRNA. Translation: AAL62462.1.
AY072876 mRNA. Translation: AAL62463.2.
CCDSiCCDS47845.1. [O75410-6]
CCDS55224.1. [O75410-3]
CCDS6109.1. [O75410-1]
RefSeqiNP_001116296.1. NM_001122824.1. [O75410-6]
NP_001139688.1. NM_001146216.2. [O75410-3]
NP_006274.2. NM_006283.2. [O75410-1]
XP_005273682.1. XM_005273625.4. [O75410-2]
XP_011542933.1. XM_011544631.1. [O75410-2]
XP_011542934.1. XM_011544632.2. [O75410-2]
XP_011542938.1. XM_011544636.2. [O75410-5]
XP_016869261.1. XM_017013772.1. [O75410-3]
XP_016869262.1. XM_017013773.1. [O75410-3]
XP_016869263.1. XM_017013774.1. [O75410-3]
UniGeneiHs.279245.

Genome annotation databases

EnsembliENST00000276520; ENSP00000276520; ENSG00000147526. [O75410-6]
ENST00000317827; ENSP00000321703; ENSG00000147526. [O75410-1]
ENST00000518415; ENSP00000428706; ENSG00000147526. [O75410-7]
ENST00000520615; ENSP00000428450; ENSG00000147526. [O75410-3]
GeneIDi6867.
KEGGihsa:6867.
UCSCiuc003xlz.4. human. [O75410-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF049910 mRNA. Translation: AAC32327.1.
AY177411 mRNA. Translation: AAO53446.1.
AY139007 mRNA. Translation: AAN28955.1.
AK314620 mRNA. Translation: BAG37186.1.
CH471080 Genomic DNA. Translation: EAW63293.1.
CH471080 Genomic DNA. Translation: EAW63296.1.
CH471080 Genomic DNA. Translation: EAW63298.1.
BC041391 mRNA. Translation: AAH41391.1.
AB029026 mRNA. Translation: BAA83055.1.
AY039239 mRNA. Translation: AAK68658.1.
AY072874 mRNA. Translation: AAL62461.1.
AY072875 mRNA. Translation: AAL62462.1.
AY072876 mRNA. Translation: AAL62463.2.
CCDSiCCDS47845.1. [O75410-6]
CCDS55224.1. [O75410-3]
CCDS6109.1. [O75410-1]
RefSeqiNP_001116296.1. NM_001122824.1. [O75410-6]
NP_001139688.1. NM_001146216.2. [O75410-3]
NP_006274.2. NM_006283.2. [O75410-1]
XP_005273682.1. XM_005273625.4. [O75410-2]
XP_011542933.1. XM_011544631.1. [O75410-2]
XP_011542934.1. XM_011544632.2. [O75410-2]
XP_011542938.1. XM_011544636.2. [O75410-5]
XP_016869261.1. XM_017013772.1. [O75410-3]
XP_016869262.1. XM_017013773.1. [O75410-3]
XP_016869263.1. XM_017013774.1. [O75410-3]
UniGeneiHs.279245.

3D structure databases

ProteinModelPortaliO75410.
SMRiO75410.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112730. 38 interactors.
IntActiO75410. 31 interactors.
MINTiMINT-8417725.
STRINGi9606.ENSP00000321703.

PTM databases

iPTMnetiO75410.
PhosphoSitePlusiO75410.

Polymorphism and mutation databases

BioMutaiTACC1.

Proteomic databases

EPDiO75410.
MaxQBiO75410.
PaxDbiO75410.
PeptideAtlasiO75410.
PRIDEiO75410.

Protocols and materials databases

DNASUi6867.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000276520; ENSP00000276520; ENSG00000147526. [O75410-6]
ENST00000317827; ENSP00000321703; ENSG00000147526. [O75410-1]
ENST00000518415; ENSP00000428706; ENSG00000147526. [O75410-7]
ENST00000520615; ENSP00000428450; ENSG00000147526. [O75410-3]
GeneIDi6867.
KEGGihsa:6867.
UCSCiuc003xlz.4. human. [O75410-1]

Organism-specific databases

CTDi6867.
DisGeNETi6867.
GeneCardsiTACC1.
H-InvDBHIX0007462.
HGNCiHGNC:11522. TACC1.
HPAiCAB017041.
HPA024702.
MalaCardsiTACC1.
MIMi605301. gene.
neXtProtiNX_O75410.
OpenTargetsiENSG00000147526.
Orphaneti251579. Giant cell glioblastoma.
251576. Gliosarcoma.
PharmGKBiPA36299.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIVK. Eukaryota.
ENOG410YMFS. LUCA.
GeneTreeiENSGT00530000063855.
HOVERGENiHBG105967.
InParanoidiO75410.
KOiK14281.
OMAiDTNDSGV.
OrthoDBiEOG091G072Z.
PhylomeDBiO75410.
TreeFamiTF333149.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000147526-MONOMER.

Miscellaneous databases

ChiTaRSiTACC1. human.
GeneWikiiTACC1.
GenomeRNAii6867.
PMAP-CutDBO75410.
PROiO75410.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000147526.
ExpressionAtlasiO75410. baseline and differential.
GenevisibleiO75410. HS.

Family and domain databases

InterProiIPR007707. TACC.
[Graphical view]
PfamiPF05010. TACC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTACC1_HUMAN
AccessioniPrimary (citable) accession number: O75410
Secondary accession number(s): B2RBD9
, D3DSX6, Q6Y687, Q86YG7, Q8IUJ2, Q8IUJ3, Q8IUJ4, Q8IZG2, Q8NEY7, Q9UPP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: February 1, 2005
Last modified: November 30, 2016
This is version 159 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.