Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O75410

- TACC1_HUMAN

UniProt

O75410 - TACC1_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Transforming acidic coiled-coil-containing protein 1

Gene

TACC1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Likely involved in the processes that promote cell division prior to the formation of differentiated tissues.

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. cerebral cortex development Source: Ensembl
  4. interkinetic nuclear migration Source: Ensembl
  5. microtubule cytoskeleton organization Source: Ensembl
  6. neurogenesis Source: Ensembl
  7. regulation of microtubule-based process Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Names & Taxonomyi

Protein namesi
Recommended name:
Transforming acidic coiled-coil-containing protein 1
Alternative name(s):
Gastric cancer antigen Ga55
Taxin-1
Gene namesi
Name:TACC1
Synonyms:KIAA1103
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:11522. TACC1.

Subcellular locationi

Cytoplasm. Nucleus. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome
Note: Nucleus during interphase. Weakly concentrated at centrosomes during mitosis and colocalizes with AURKC at the midbody during cytokinesis.

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. intermediate filament cytoskeleton Source: HPA
  3. microtubule cytoskeleton Source: HPA
  4. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi228 – 2281S → A: Impairs phosphorylation by AURKC. 1 Publication

Organism-specific databases

Orphaneti251579. Giant cell glioblastoma.
251576. Gliosarcoma.
PharmGKBiPA36299.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 805804Transforming acidic coiled-coil-containing protein 1PRO_0000179986Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication
Modified residuei4 – 41Phosphoserine1 Publication
Modified residuei10 – 101Phosphoserine1 Publication
Modified residuei228 – 2281Phosphoserine; by AURKC1 Publication
Modified residuei276 – 2761Phosphoserine1 Publication
Modified residuei381 – 3811PhosphoserineBy similarity
Modified residuei533 – 5331Phosphotyrosine1 Publication

Post-translational modificationi

Isoform 1 is heavily phosphorylated; isoform 6 is not.5 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiO75410.
PaxDbiO75410.
PRIDEiO75410.

PTM databases

PhosphoSiteiO75410.

Miscellaneous databases

PMAP-CutDBO75410.

Expressioni

Tissue specificityi

Isoform 1, isoform 3 and isoform 5 are ubiquitous. Isoform 2 is strongly expressed in the brain, weakly detectable in lung and colon, and overexpressed in gastric cancer. Isoform 4 is not detected in normal tissues, but strong expression was found in gastric cancer tissues. Down-regulated in a subset of cases of breast cancer.2 Publications

Developmental stagei

Expressed at high level during early embryogenesis.

Gene expression databases

BgeeiO75410.
ExpressionAtlasiO75410. baseline and differential.
GenevestigatoriO75410.

Organism-specific databases

HPAiCAB017041.
HPA024702.

Interactioni

Subunit structurei

Interacts with KIAA0097/CH-TOG and with the oncogenic transcription factor YEATS4. Interacts with AURKA, AURKB and AURKC. Interacts with LSM7, TDRD7 and SNRPG. Interacts with GCN5L2 and PCAF.6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
AURKBQ96GD42EBI-624278,EBI-624291
CKAP5Q140083EBI-624237,EBI-310585
HTTP428584EBI-624237,EBI-466029
LSM7Q9UK454EBI-624252,EBI-348372
SNRPGP623085EBI-624252,EBI-624585
TDRD7Q8NHU64EBI-624237,EBI-624505
YEATS4O956196EBI-624237,EBI-399269

Protein-protein interaction databases

BioGridi112730. 20 interactions.
IntActiO75410. 13 interactions.
MINTiMINT-8417725.

Structurei

3D structure databases

ProteinModelPortaliO75410.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini215 – 29783SPAZ 1Add
BLAST
Domaini359 – 507149SPAZ 2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 5554Interaction with LSM7 and SNRPGAdd
BLAST
Regioni152 – 259108Interaction with TDRD7Add
BLAST
Regioni206 – 427222Interaction with YEATS4Add
BLAST
Regioni701 – 805105Interaction with CH-TOGAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili610 – 805196Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi226 – 24116Bipartite nuclear localization signal 1Sequence AnalysisAdd
BLAST
Motifi455 – 47117Bipartite nuclear localization signal 2Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the TACC family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiNOG83363.
GeneTreeiENSGT00530000063855.
HOVERGENiHBG105967.
InParanoidiO75410.
KOiK14281.
OMAiSFQQLTM.
PhylomeDBiO75410.
TreeFamiTF333149.

Family and domain databases

InterProiIPR007707. TACC.
[Graphical view]
PANTHERiPTHR13924. PTHR13924. 1 hit.
PfamiPF05010. TACC. 1 hit.
[Graphical view]

Sequences (8)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 8 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: O75410-1) [UniParc]FASTAAdd to Basket

Also known as: A, Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAFSPWQILS PVQWAKWTWS AVRGGAAGED EAGGPEGDPE EEDSQAETKS
60 70 80 90 100
LSFSSDSEGN FETPEAETPI RSPFKESCDP SLGLAGPGAK SQESQEADEQ
110 120 130 140 150
LVAEVVEKCS SKTCSKPSEN EVPQQAIDSH SVKNFREEPE HDFSKISIVR
160 170 180 190 200
PFSIETKDST DISAVLGTKA AHGCVTAVSG KALPSSPPDA LQDEAMTEGS
210 220 230 240 250
MGVTLEASAE ADLKAGNSCP ELVPSRRSKL RKPKPVPLRK KAIGGEFSDT
260 270 280 290 300
NAAVEGTPLP KASYHFSPEE LDENTSPLLG DARFQKSPPD LKETPGTLSS
310 320 330 340 350
DTNDSGVELG EESRSSPLKL EFDFTEDTGN IEARKALPRK LGRKLGSTLT
360 370 380 390 400
PKIQKDGISK SAGLEQPTDP VARDGPLSQT SSKPDPSQWE SPSFNPFGSH
410 420 430 440 450
SVLQNSPPLS SEGSYHFDPD NFDESMDPFK PTTTLTSSDF CSPTGNHVNE
460 470 480 490 500
ILESPKKAKS RLITSGCKVK KHETQSLALD ACSRDEGAVI SQISDISNRD
510 520 530 540 550
GHATDEEKLA STSCGQKSAG AEVKGEPEED LEYFECSNVP VSTINHAFSS
560 570 580 590 600
SEAGIEKETC QKMEEDGSTV LGLLESSAEK APVSVSCGGE SPLDGICLSE
610 620 630 640 650
SDKTAVLTLI REEIITKEIE ANEWKKKYEE TRQEVLEMRK IVAEYEKTIA
660 670 680 690 700
QMIEDEQRTS MTSQKSFQQL TMEKEQALAD LNSVERSLSD LFRRYENLKG
710 720 730 740 750
VLEGFKKNEE ALKKCAQDYL ARVKQEEQRY QALKIHAEEK LDKANEEIAQ
760 770 780 790 800
VRTKAKAESA ALHAGLRKEQ MKVESLERAL QQKNQEIEEL TKICDELIAK

LGKTD
Length:805
Mass (Da):87,794
Last modified:February 1, 2005 - v2
Checksum:i3A261EF58C165107
GO
Isoform 2 (identifier: O75410-2) [UniParc]FASTAAdd to Basket

Also known as: F

The sequence of this isoform differs from the canonical sequence as follows:
     464-464: T → TTTEQVKFLCFLL

Show »
Length:817
Mass (Da):89,218
Checksum:iB9D4BDE7B742E813
GO
Isoform 3 (identifier: O75410-3) [UniParc]FASTAAdd to Basket

Also known as: E

The sequence of this isoform differs from the canonical sequence as follows:
     1-195: Missing.

Show »
Length:610
Mass (Da):67,073
Checksum:i802527D4B613A881
GO
Isoform 4 (identifier: O75410-4) [UniParc]FASTAAdd to Basket

Also known as: D

The sequence of this isoform differs from the canonical sequence as follows:
     1-426: Missing.
     427-464: DPFKPTTTLT...PKKAKSRLIT → MGGSHSQTPR...EQVKFLCFLL

Show »
Length:379
Mass (Da):42,326
Checksum:iA3CF1029DF65E860
GO
Isoform 5 (identifier: O75410-5) [UniParc]FASTAAdd to Basket

Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     1-438: Missing.
     439-464: DFCSPTGNHVNEILESPKKAKSRLIT → MGGSHSQTPRGREPAGERHPRPTETA

Show »
Length:367
Mass (Da):40,903
Checksum:iF1761EA28D5AB9A8
GO
Isoform 6 (identifier: O75410-6) [UniParc]FASTAAdd to Basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     54-54: S → R
     55-464: Missing.

Show »
Length:395
Mass (Da):43,984
Checksum:iB29F0EA1DCAAF8E1
GO
Isoform 7 (identifier: O75410-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-41: Missing.
     42-53: EDSQAETKSLSF → MNNILKLK
     525-553: Missing.

Show »
Length:731
Mass (Da):79,872
Checksum:i385263AECC0C7060
GO
Isoform 8 (identifier: O75410-8) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-651: Missing.

Show »
Length:154
Mass (Da):17,815
Checksum:iF7CF945C5A3E277D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti291 – 2911L → I in AAC32327. (PubMed:10435627)Curated
Sequence conflicti428 – 4281P → H in AAH41391. (PubMed:15489334)Curated
Sequence conflicti588 – 5881G → V in BAA83055. (PubMed:10470851)Curated
Sequence conflicti654 – 6541Missing in BAA83055. (PubMed:10470851)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti187 – 1871P → L.
Corresponds to variant rs34235313 [ dbSNP | Ensembl ].
VAR_053703
Natural varianti243 – 2431I → T.
Corresponds to variant rs6980553 [ dbSNP | Ensembl ].
VAR_053704
Natural varianti255 – 2551E → G.
Corresponds to variant rs10107016 [ dbSNP | Ensembl ].
VAR_053705

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 651651Missing in isoform 8. 1 PublicationVSP_012640Add
BLAST
Alternative sequencei1 – 438438Missing in isoform 5. CuratedVSP_012639Add
BLAST
Alternative sequencei1 – 426426Missing in isoform 4. CuratedVSP_012641Add
BLAST
Alternative sequencei1 – 195195Missing in isoform 3. 1 PublicationVSP_012638Add
BLAST
Alternative sequencei1 – 4141Missing in isoform 7. 1 PublicationVSP_012637Add
BLAST
Alternative sequencei42 – 5312EDSQA…KSLSF → MNNILKLK in isoform 7. 1 PublicationVSP_012643Add
BLAST
Alternative sequencei54 – 541S → R in isoform 6. 1 PublicationVSP_012644
Alternative sequencei55 – 464410Missing in isoform 6. 1 PublicationVSP_012645Add
BLAST
Alternative sequencei427 – 46438DPFKP…SRLIT → MGGSHSQTPRGREPAGERHP RPTETATTEQVKFLCFLL in isoform 4. CuratedVSP_012642Add
BLAST
Alternative sequencei439 – 46426DFCSP…SRLIT → MGGSHSQTPRGREPAGERHP RPTETA in isoform 5. CuratedVSP_012646Add
BLAST
Alternative sequencei464 – 4641T → TTTEQVKFLCFLL in isoform 2. 2 PublicationsVSP_012647
Alternative sequencei525 – 55329Missing in isoform 7. 1 PublicationVSP_012648Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF049910 mRNA. Translation: AAC32327.1.
AY177411 mRNA. Translation: AAO53446.1.
AY139007 mRNA. Translation: AAN28955.1.
AK314620 mRNA. Translation: BAG37186.1.
CH471080 Genomic DNA. Translation: EAW63293.1.
CH471080 Genomic DNA. Translation: EAW63296.1.
CH471080 Genomic DNA. Translation: EAW63298.1.
BC041391 mRNA. Translation: AAH41391.1.
AB029026 mRNA. Translation: BAA83055.1.
AY039239 mRNA. Translation: AAK68658.1.
AY072874 mRNA. Translation: AAL62461.1.
AY072875 mRNA. Translation: AAL62462.1.
AY072876 mRNA. Translation: AAL62463.2.
CCDSiCCDS47845.1. [O75410-6]
CCDS55224.1. [O75410-3]
CCDS6109.1. [O75410-1]
RefSeqiNP_001116296.1. NM_001122824.1. [O75410-6]
NP_001139688.1. NM_001146216.2. [O75410-3]
NP_006274.2. NM_006283.2. [O75410-1]
XP_005273682.1. XM_005273625.2. [O75410-2]
UniGeneiHs.279245.

Genome annotation databases

EnsembliENST00000276520; ENSP00000276520; ENSG00000147526. [O75410-6]
ENST00000317827; ENSP00000321703; ENSG00000147526. [O75410-1]
ENST00000518415; ENSP00000428706; ENSG00000147526. [O75410-7]
ENST00000520615; ENSP00000428450; ENSG00000147526. [O75410-3]
ENST00000521050; ENSP00000428949; ENSG00000147526.
ENST00000521642; ENSP00000428466; ENSG00000147526.
GeneIDi6867.
KEGGihsa:6867.
UCSCiuc003xlz.3. human. [O75410-1]
uc003xma.3. human. [O75410-5]
uc003xmb.4. human. [O75410-7]
uc003xmf.4. human. [O75410-6]
uc003xmh.4. human. [O75410-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF049910 mRNA. Translation: AAC32327.1 .
AY177411 mRNA. Translation: AAO53446.1 .
AY139007 mRNA. Translation: AAN28955.1 .
AK314620 mRNA. Translation: BAG37186.1 .
CH471080 Genomic DNA. Translation: EAW63293.1 .
CH471080 Genomic DNA. Translation: EAW63296.1 .
CH471080 Genomic DNA. Translation: EAW63298.1 .
BC041391 mRNA. Translation: AAH41391.1 .
AB029026 mRNA. Translation: BAA83055.1 .
AY039239 mRNA. Translation: AAK68658.1 .
AY072874 mRNA. Translation: AAL62461.1 .
AY072875 mRNA. Translation: AAL62462.1 .
AY072876 mRNA. Translation: AAL62463.2 .
CCDSi CCDS47845.1. [O75410-6 ]
CCDS55224.1. [O75410-3 ]
CCDS6109.1. [O75410-1 ]
RefSeqi NP_001116296.1. NM_001122824.1. [O75410-6 ]
NP_001139688.1. NM_001146216.2. [O75410-3 ]
NP_006274.2. NM_006283.2. [O75410-1 ]
XP_005273682.1. XM_005273625.2. [O75410-2 ]
UniGenei Hs.279245.

3D structure databases

ProteinModelPortali O75410.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112730. 20 interactions.
IntActi O75410. 13 interactions.
MINTi MINT-8417725.

PTM databases

PhosphoSitei O75410.

Proteomic databases

MaxQBi O75410.
PaxDbi O75410.
PRIDEi O75410.

Protocols and materials databases

DNASUi 6867.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000276520 ; ENSP00000276520 ; ENSG00000147526 . [O75410-6 ]
ENST00000317827 ; ENSP00000321703 ; ENSG00000147526 . [O75410-1 ]
ENST00000518415 ; ENSP00000428706 ; ENSG00000147526 . [O75410-7 ]
ENST00000520615 ; ENSP00000428450 ; ENSG00000147526 . [O75410-3 ]
ENST00000521050 ; ENSP00000428949 ; ENSG00000147526 .
ENST00000521642 ; ENSP00000428466 ; ENSG00000147526 .
GeneIDi 6867.
KEGGi hsa:6867.
UCSCi uc003xlz.3. human. [O75410-1 ]
uc003xma.3. human. [O75410-5 ]
uc003xmb.4. human. [O75410-7 ]
uc003xmf.4. human. [O75410-6 ]
uc003xmh.4. human. [O75410-2 ]

Organism-specific databases

CTDi 6867.
GeneCardsi GC08P038586.
H-InvDB HIX0007462.
HGNCi HGNC:11522. TACC1.
HPAi CAB017041.
HPA024702.
MIMi 605301. gene.
neXtProti NX_O75410.
Orphaneti 251579. Giant cell glioblastoma.
251576. Gliosarcoma.
PharmGKBi PA36299.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG83363.
GeneTreei ENSGT00530000063855.
HOVERGENi HBG105967.
InParanoidi O75410.
KOi K14281.
OMAi SFQQLTM.
PhylomeDBi O75410.
TreeFami TF333149.

Miscellaneous databases

ChiTaRSi TACC1. human.
GeneWikii TACC1.
GenomeRNAii 6867.
NextBioi 26803.
PMAP-CutDB O75410.
PROi O75410.
SOURCEi Search...

Gene expression databases

Bgeei O75410.
ExpressionAtlasi O75410. baseline and differential.
Genevestigatori O75410.

Family and domain databases

InterProi IPR007707. TACC.
[Graphical view ]
PANTHERi PTHR13924. PTHR13924. 1 hit.
Pfami PF05010. TACC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of TACC1, an embryonically expressed, potentially transforming coiled coil containing gene, from the 8p11 breast cancer amplicon."
    Still I.H., Hamilton M., Vince P., Wolfman A., Cowell J.K.
    Oncogene 18:4032-4038(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Structure-function evolution of the transforming acidic coiled coil genes revealed by analysis of phylogenetically diverse organisms."
    Still I.H., Vettaikkorumakankauv A.K., DiMatteo A., Liang P.
    BMC Evol. Biol. 4:16-16(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 6).
  3. "Cloning of a novel human gene similar to TACC1."
    Li F., Yao K.T.
    Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 8).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7).
    Tissue: Brain.
  7. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 364-805 (ISOFORM 2).
    Tissue: Brain.
  8. "Serological identification and expression analysis of gastric cancer-associated genes."
    Line A., Stengrevics A., Slucka Z., Li G., Jankevics E., Rees R.C.
    Br. J. Cancer 86:1824-1830(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 450-805 (ISOFORM 2).
    Tissue: Gastric adenocarcinoma.
  9. "Altered splicing pattern of TACC1 mRNA in gastric cancer."
    Line A., Slucka Z., Stengrevics A., Li G., Rees R.C.
    Cancer Genet. Cytogenet. 139:78-83(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-543 (ISOFORM 3), NUCLEOTIDE SEQUENCE OF 1-571 (ISOFORMS 4 AND 5), TISSUE SPECIFICITY.
    Tissue: Stomach cancer.
  10. "The TACC domain identifies a family of centrosomal proteins that can interact with microtubules."
    Gergely F., Karlsson C., Still I.H., Cowell J.K., Kilmartin J., Raff J.W.
    Proc. Natl. Acad. Sci. U.S.A. 97:14352-14357(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
    Tissue: Brain, Fetal brain and Skeletal muscle.
  11. "Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells."
    Lauffart B., Howell S.J., Tasch J.E., Cowell J.K., Still I.H.
    Biochem. J. 363:195-200(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH KIAA0097 AND YEATS4.
  12. "Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators."
    Conte N., Charafe-Jauffret E., Delaval B., Adelaide J., Ginestier C., Geneix J., Isnardon D., Jacquemier J., Birnbaum D.
    Oncogene 21:5619-5630(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH LSM7 AND SNRPG, TISSUE SPECIFICITY, PHOSPHORYLATION.
  13. Cited for: INTERACTION WITH KIAA0097; LSM7; TDRD7 AND AURKA.
  14. "The transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases."
    Gangisetty O., Lauffart B., Sondarva G.V., Chelsea D.M., Still I.H.
    Oncogene 23:2559-2563(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GCN5L2 AND PCAF, SUBCELLULAR LOCATION.
  15. Cited for: INTERACTION WITH AURKB.
  16. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
    Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
    Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-533, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  17. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  18. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  19. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  20. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-276, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  21. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4 AND SER-10, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  22. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  23. Cited for: SUBCELLULAR LOCATION, INTERACTION WITH AURKC, PHOSPHORYLATION AT SER-228 BY AURKC, MUTAGENESIS OF SER-228.

Entry informationi

Entry nameiTACC1_HUMAN
AccessioniPrimary (citable) accession number: O75410
Secondary accession number(s): B2RBD9
, D3DSX6, Q6Y687, Q86YG7, Q8IUJ2, Q8IUJ3, Q8IUJ4, Q8IZG2, Q8NEY7, Q9UPP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: February 1, 2005
Last modified: November 26, 2014
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3