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Protein

Transforming acidic coiled-coil-containing protein 1

Gene

TACC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Likely involved in the processes that promote cell division prior to the formation of differentiated tissues.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Names & Taxonomyi

Protein namesi
Recommended name:
Transforming acidic coiled-coil-containing protein 1
Alternative name(s):
Gastric cancer antigen Ga55
Taxin-1
Gene namesi
Name:TACC1
Synonyms:KIAA1103
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:11522. TACC1.

Subcellular locationi

Isoform 5 :

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi228 – 2281S → A: Impairs phosphorylation by AURKC. 1 Publication

Organism-specific databases

MalaCardsiTACC1.
Orphaneti251579. Giant cell glioblastoma.
251576. Gliosarcoma.
PharmGKBiPA36299.

Polymorphism and mutation databases

BioMutaiTACC1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 805804Transforming acidic coiled-coil-containing protein 1PRO_0000179986Add
BLAST
Isoform 5 (identifier: O75410-5)
Initiator methionineiRemoved1 Publication

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources
Modified residuei4 – 41PhosphoserineCombined sources
Modified residuei10 – 101PhosphoserineCombined sources
Modified residuei44 – 441PhosphoserineCombined sources
Modified residuei147 – 1471PhosphoserineCombined sources
Modified residuei153 – 1531PhosphoserineCombined sources
Modified residuei228 – 2281Phosphoserine; by AURKC1 Publication
Modified residuei248 – 2481PhosphoserineCombined sources
Modified residuei276 – 2761PhosphoserineCombined sources
Modified residuei381 – 3811PhosphoserineBy similarity
Modified residuei406 – 4061PhosphoserineBy similarity
Modified residuei483 – 4831PhosphoserineBy similarity
Modified residuei533 – 5331PhosphotyrosineCombined sources
Modified residuei591 – 5911PhosphoserineCombined sources
Isoform 5 (identifier: O75410-5)
Lipidationi2 – 21N-myristoyl glycine1 Publication

Post-translational modificationi

Isoform 1 is heavily phosphorylated; isoform 6 is not.2 Publications

Keywords - PTMi

Acetylation, Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDiO75410.
MaxQBiO75410.
PaxDbiO75410.
PeptideAtlasiO75410.
PRIDEiO75410.

PTM databases

iPTMnetiO75410.
PhosphoSiteiO75410.

Miscellaneous databases

PMAP-CutDBO75410.

Expressioni

Tissue specificityi

Isoform 1, isoform 3 and isoform 5 are ubiquitous. Isoform 2 is strongly expressed in the brain, weakly detectable in lung and colon, and overexpressed in gastric cancer. Isoform 4 is not detected in normal tissues, but strong expression was found in gastric cancer tissues. Down-regulated in a subset of cases of breast cancer.2 Publications

Developmental stagei

Expressed at high level during early embryogenesis.

Gene expression databases

BgeeiENSG00000147526.
ExpressionAtlasiO75410. baseline and differential.
GenevisibleiO75410. HS.

Organism-specific databases

HPAiCAB017041.
HPA024702.

Interactioni

Subunit structurei

Interacts with KIAA0097/CH-TOG and with the oncogenic transcription factor YEATS4. Interacts with AURKA, AURKB and AURKC. Interacts with LSM7, TDRD7 and SNRPG. Interacts with GCN5L2 and PCAF.6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
AURKBQ96GD42EBI-624278,EBI-624291
BTRCQ9Y2973EBI-624237,EBI-307461
CKAP5Q140084EBI-624237,EBI-310585
HTTP428584EBI-624237,EBI-466029
LSM7Q9UK454EBI-624252,EBI-348372
MEMO1Q9Y3164EBI-624237,EBI-1104564
SH2D4AQ9H7883EBI-624237,EBI-747035
SNRPGP623085EBI-624252,EBI-624585
STX5Q131903EBI-624237,EBI-714206
TDRD7Q8NHU64EBI-624237,EBI-624505
THAP12O434223EBI-624237,EBI-2828217
YEATS4O956196EBI-624237,EBI-399269

Protein-protein interaction databases

BioGridi112730. 38 interactions.
IntActiO75410. 26 interactions.
MINTiMINT-8417725.
STRINGi9606.ENSP00000321703.

Structurei

3D structure databases

ProteinModelPortaliO75410.
SMRiO75410. Positions 666-694, 758-803.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini215 – 29783SPAZ 1Add
BLAST
Domaini359 – 507149SPAZ 2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 5554Interaction with LSM7 and SNRPGAdd
BLAST
Regioni152 – 259108Interaction with TDRD7Add
BLAST
Regioni206 – 427222Interaction with YEATS4Add
BLAST
Regioni701 – 805105Interaction with CH-TOGAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili610 – 805196Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi226 – 24116Bipartite nuclear localization signal 1Sequence analysisAdd
BLAST
Motifi455 – 47117Bipartite nuclear localization signal 2Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the TACC family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410IIVK. Eukaryota.
ENOG410YMFS. LUCA.
GeneTreeiENSGT00530000063855.
HOVERGENiHBG105967.
InParanoidiO75410.
KOiK14281.
OMAiDTNDSGV.
OrthoDBiEOG091G072Z.
PhylomeDBiO75410.
TreeFamiTF333149.

Family and domain databases

InterProiIPR007707. TACC.
[Graphical view]
PfamiPF05010. TACC. 1 hit.
[Graphical view]

Sequences (8)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 8 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: O75410-1) [UniParc]FASTAAdd to basket
Also known as: A, Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAFSPWQILS PVQWAKWTWS AVRGGAAGED EAGGPEGDPE EEDSQAETKS
60 70 80 90 100
LSFSSDSEGN FETPEAETPI RSPFKESCDP SLGLAGPGAK SQESQEADEQ
110 120 130 140 150
LVAEVVEKCS SKTCSKPSEN EVPQQAIDSH SVKNFREEPE HDFSKISIVR
160 170 180 190 200
PFSIETKDST DISAVLGTKA AHGCVTAVSG KALPSSPPDA LQDEAMTEGS
210 220 230 240 250
MGVTLEASAE ADLKAGNSCP ELVPSRRSKL RKPKPVPLRK KAIGGEFSDT
260 270 280 290 300
NAAVEGTPLP KASYHFSPEE LDENTSPLLG DARFQKSPPD LKETPGTLSS
310 320 330 340 350
DTNDSGVELG EESRSSPLKL EFDFTEDTGN IEARKALPRK LGRKLGSTLT
360 370 380 390 400
PKIQKDGISK SAGLEQPTDP VARDGPLSQT SSKPDPSQWE SPSFNPFGSH
410 420 430 440 450
SVLQNSPPLS SEGSYHFDPD NFDESMDPFK PTTTLTSSDF CSPTGNHVNE
460 470 480 490 500
ILESPKKAKS RLITSGCKVK KHETQSLALD ACSRDEGAVI SQISDISNRD
510 520 530 540 550
GHATDEEKLA STSCGQKSAG AEVKGEPEED LEYFECSNVP VSTINHAFSS
560 570 580 590 600
SEAGIEKETC QKMEEDGSTV LGLLESSAEK APVSVSCGGE SPLDGICLSE
610 620 630 640 650
SDKTAVLTLI REEIITKEIE ANEWKKKYEE TRQEVLEMRK IVAEYEKTIA
660 670 680 690 700
QMIEDEQRTS MTSQKSFQQL TMEKEQALAD LNSVERSLSD LFRRYENLKG
710 720 730 740 750
VLEGFKKNEE ALKKCAQDYL ARVKQEEQRY QALKIHAEEK LDKANEEIAQ
760 770 780 790 800
VRTKAKAESA ALHAGLRKEQ MKVESLERAL QQKNQEIEEL TKICDELIAK

LGKTD
Length:805
Mass (Da):87,794
Last modified:February 1, 2005 - v2
Checksum:i3A261EF58C165107
GO
Isoform 2 (identifier: O75410-2) [UniParc]FASTAAdd to basket
Also known as: F

The sequence of this isoform differs from the canonical sequence as follows:
     464-464: T → TTTEQVKFLCFLL

Show »
Length:817
Mass (Da):89,218
Checksum:iB9D4BDE7B742E813
GO
Isoform 3 (identifier: O75410-3) [UniParc]FASTAAdd to basket
Also known as: E

The sequence of this isoform differs from the canonical sequence as follows:
     1-195: Missing.

Show »
Length:610
Mass (Da):67,073
Checksum:i802527D4B613A881
GO
Isoform 4 (identifier: O75410-4) [UniParc]FASTAAdd to basket
Also known as: D

The sequence of this isoform differs from the canonical sequence as follows:
     1-426: Missing.
     427-464: DPFKPTTTLT...PKKAKSRLIT → MGGSHSQTPR...EQVKFLCFLL

Show »
Length:379
Mass (Da):42,326
Checksum:iA3CF1029DF65E860
GO
Isoform 5 (identifier: O75410-5) [UniParc]FASTAAdd to basket
Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     1-438: Missing.
     439-464: DFCSPTGNHVNEILESPKKAKSRLIT → MGGSHSQTPRGREPAGERHPRPTETA

Show »
Length:367
Mass (Da):40,903
Checksum:iF1761EA28D5AB9A8
GO
Isoform 6 (identifier: O75410-6) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     54-54: S → R
     55-464: Missing.

Show »
Length:395
Mass (Da):43,984
Checksum:iB29F0EA1DCAAF8E1
GO
Isoform 7 (identifier: O75410-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-41: Missing.
     42-53: EDSQAETKSLSF → MNNILKLK
     525-553: Missing.

Show »
Length:731
Mass (Da):79,872
Checksum:i385263AECC0C7060
GO
Isoform 8 (identifier: O75410-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-651: Missing.

Show »
Length:154
Mass (Da):17,815
Checksum:iF7CF945C5A3E277D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti291 – 2911L → I in AAC32327 (PubMed:10435627).Curated
Sequence conflicti428 – 4281P → H in AAH41391 (PubMed:15489334).Curated
Sequence conflicti588 – 5881G → V in BAA83055 (PubMed:10470851).Curated
Sequence conflicti654 – 6541Missing in BAA83055 (PubMed:10470851).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti187 – 1871P → L.
Corresponds to variant rs34235313 [ dbSNP | Ensembl ].
VAR_053703
Natural varianti243 – 2431I → T.
Corresponds to variant rs6980553 [ dbSNP | Ensembl ].
VAR_053704
Natural varianti255 – 2551E → G.
Corresponds to variant rs10107016 [ dbSNP | Ensembl ].
VAR_053705

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 651651Missing in isoform 8. 1 PublicationVSP_012640Add
BLAST
Alternative sequencei1 – 438438Missing in isoform 5. CuratedVSP_012639Add
BLAST
Alternative sequencei1 – 426426Missing in isoform 4. CuratedVSP_012641Add
BLAST
Alternative sequencei1 – 195195Missing in isoform 3. 1 PublicationVSP_012638Add
BLAST
Alternative sequencei1 – 4141Missing in isoform 7. 1 PublicationVSP_012637Add
BLAST
Alternative sequencei42 – 5312EDSQA…KSLSF → MNNILKLK in isoform 7. 1 PublicationVSP_012643Add
BLAST
Alternative sequencei54 – 541S → R in isoform 6. 1 PublicationVSP_012644
Alternative sequencei55 – 464410Missing in isoform 6. 1 PublicationVSP_012645Add
BLAST
Alternative sequencei427 – 46438DPFKP…SRLIT → MGGSHSQTPRGREPAGERHP RPTETATTEQVKFLCFLL in isoform 4. CuratedVSP_012642Add
BLAST
Alternative sequencei439 – 46426DFCSP…SRLIT → MGGSHSQTPRGREPAGERHP RPTETA in isoform 5. CuratedVSP_012646Add
BLAST
Alternative sequencei464 – 4641T → TTTEQVKFLCFLL in isoform 2. 2 PublicationsVSP_012647
Alternative sequencei525 – 55329Missing in isoform 7. 1 PublicationVSP_012648Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF049910 mRNA. Translation: AAC32327.1.
AY177411 mRNA. Translation: AAO53446.1.
AY139007 mRNA. Translation: AAN28955.1.
AK314620 mRNA. Translation: BAG37186.1.
CH471080 Genomic DNA. Translation: EAW63293.1.
CH471080 Genomic DNA. Translation: EAW63296.1.
CH471080 Genomic DNA. Translation: EAW63298.1.
BC041391 mRNA. Translation: AAH41391.1.
AB029026 mRNA. Translation: BAA83055.1.
AY039239 mRNA. Translation: AAK68658.1.
AY072874 mRNA. Translation: AAL62461.1.
AY072875 mRNA. Translation: AAL62462.1.
AY072876 mRNA. Translation: AAL62463.2.
CCDSiCCDS47845.1. [O75410-6]
CCDS55224.1. [O75410-3]
CCDS6109.1. [O75410-1]
RefSeqiNP_001116296.1. NM_001122824.1. [O75410-6]
NP_001139688.1. NM_001146216.2. [O75410-3]
NP_006274.2. NM_006283.2. [O75410-1]
XP_005273682.1. XM_005273625.4. [O75410-2]
XP_011542933.1. XM_011544631.1. [O75410-2]
XP_011542934.1. XM_011544632.2. [O75410-2]
XP_011542938.1. XM_011544636.2. [O75410-5]
UniGeneiHs.279245.

Genome annotation databases

EnsembliENST00000276520; ENSP00000276520; ENSG00000147526. [O75410-6]
ENST00000317827; ENSP00000321703; ENSG00000147526. [O75410-1]
ENST00000518415; ENSP00000428706; ENSG00000147526. [O75410-7]
ENST00000520615; ENSP00000428450; ENSG00000147526. [O75410-3]
GeneIDi6867.
KEGGihsa:6867.
UCSCiuc003xlz.4. human. [O75410-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF049910 mRNA. Translation: AAC32327.1.
AY177411 mRNA. Translation: AAO53446.1.
AY139007 mRNA. Translation: AAN28955.1.
AK314620 mRNA. Translation: BAG37186.1.
CH471080 Genomic DNA. Translation: EAW63293.1.
CH471080 Genomic DNA. Translation: EAW63296.1.
CH471080 Genomic DNA. Translation: EAW63298.1.
BC041391 mRNA. Translation: AAH41391.1.
AB029026 mRNA. Translation: BAA83055.1.
AY039239 mRNA. Translation: AAK68658.1.
AY072874 mRNA. Translation: AAL62461.1.
AY072875 mRNA. Translation: AAL62462.1.
AY072876 mRNA. Translation: AAL62463.2.
CCDSiCCDS47845.1. [O75410-6]
CCDS55224.1. [O75410-3]
CCDS6109.1. [O75410-1]
RefSeqiNP_001116296.1. NM_001122824.1. [O75410-6]
NP_001139688.1. NM_001146216.2. [O75410-3]
NP_006274.2. NM_006283.2. [O75410-1]
XP_005273682.1. XM_005273625.4. [O75410-2]
XP_011542933.1. XM_011544631.1. [O75410-2]
XP_011542934.1. XM_011544632.2. [O75410-2]
XP_011542938.1. XM_011544636.2. [O75410-5]
UniGeneiHs.279245.

3D structure databases

ProteinModelPortaliO75410.
SMRiO75410. Positions 666-694, 758-803.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112730. 38 interactions.
IntActiO75410. 26 interactions.
MINTiMINT-8417725.
STRINGi9606.ENSP00000321703.

PTM databases

iPTMnetiO75410.
PhosphoSiteiO75410.

Polymorphism and mutation databases

BioMutaiTACC1.

Proteomic databases

EPDiO75410.
MaxQBiO75410.
PaxDbiO75410.
PeptideAtlasiO75410.
PRIDEiO75410.

Protocols and materials databases

DNASUi6867.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000276520; ENSP00000276520; ENSG00000147526. [O75410-6]
ENST00000317827; ENSP00000321703; ENSG00000147526. [O75410-1]
ENST00000518415; ENSP00000428706; ENSG00000147526. [O75410-7]
ENST00000520615; ENSP00000428450; ENSG00000147526. [O75410-3]
GeneIDi6867.
KEGGihsa:6867.
UCSCiuc003xlz.4. human. [O75410-1]

Organism-specific databases

CTDi6867.
GeneCardsiTACC1.
H-InvDBHIX0007462.
HGNCiHGNC:11522. TACC1.
HPAiCAB017041.
HPA024702.
MalaCardsiTACC1.
MIMi605301. gene.
neXtProtiNX_O75410.
Orphaneti251579. Giant cell glioblastoma.
251576. Gliosarcoma.
PharmGKBiPA36299.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIVK. Eukaryota.
ENOG410YMFS. LUCA.
GeneTreeiENSGT00530000063855.
HOVERGENiHBG105967.
InParanoidiO75410.
KOiK14281.
OMAiDTNDSGV.
OrthoDBiEOG091G072Z.
PhylomeDBiO75410.
TreeFamiTF333149.

Miscellaneous databases

ChiTaRSiTACC1. human.
GeneWikiiTACC1.
GenomeRNAii6867.
PMAP-CutDBO75410.
PROiO75410.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000147526.
ExpressionAtlasiO75410. baseline and differential.
GenevisibleiO75410. HS.

Family and domain databases

InterProiIPR007707. TACC.
[Graphical view]
PfamiPF05010. TACC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTACC1_HUMAN
AccessioniPrimary (citable) accession number: O75410
Secondary accession number(s): B2RBD9
, D3DSX6, Q6Y687, Q86YG7, Q8IUJ2, Q8IUJ3, Q8IUJ4, Q8IZG2, Q8NEY7, Q9UPP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: February 1, 2005
Last modified: September 7, 2016
This is version 156 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.