O75410 (TACC1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transforming acidic coiled-coil-containing protein 1

Alternative name(s):
Gastric cancer antigen Ga55
Taxin-1

Gene names

Name:	TACC1
Synonyms:	KIAA1103

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	805 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Likely involved in the processes that promote cell division prior to the formation of differentiated tissues.
Subunit structure	Interacts with KIAA0097/CH-TOG and with the oncogenic transcription factor YEATS4. Interacts with AURKA, AURKB and AURKC. Interacts with LSM7, TDRD7 and SNRPG. Interacts with GCN5L2 and PCAF. Ref.11 Ref.12 Ref.13 Ref.14 Ref.15 Ref.19
Subcellular location	Cytoplasm. Nucleus. Cytoplasm › cytoskeleton › centrosome. Note: Nucleus during interphase. Weakly concentrated at centrosomes during mitosis and colocalizes with AURKC at the midbody during cytokinesis. Ref.14 Ref.19
Tissue specificity	Isoform 1, isoform 3 and isoform 5 are ubiquitous. Isoform 2 is strongly expressed in the brain, weakly detectable in lung and colon, and overexpressed in gastric cancer. Isoform 4 is not detected in normal tissues, but strong expression was found in gastric cancer tissues. Down-regulated in a subset of cases of breast cancer. Ref.9 Ref.12
Developmental stage	Expressed at high level during early embryogenesis.
Post-translational modification	Isoform 1 is heavily phosphorylated; isoform 6 is not. Phosphorylated upon DNA damage, probably by ATM or ATR. Ref.12 Ref.16 Ref.17 Ref.18 Ref.19 Ref.20
Sequence similarities	Belongs to the TACC family. Contains 2 SPAZ (Ser/Pro-rich AZU-1) domains.

Ontologies

Keywords
Biological process	Cell cycle Cell division
Cellular component	Cytoplasm Cytoskeleton Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Repeat
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	intermediate filament cytoskeleton Inferred from direct assay. Source: HPA microtubule organizing center Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein binding Inferred from physical interaction Ref.11Ref.12Ref.13Ref.15. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
AURKB	Q96GD4	2	EBI-624278,EBI-624291
CKAP5	Q14008	3	EBI-624237,EBI-310585
LSM7	Q9UK45	4	EBI-624252,EBI-348372
SNRPG	P62308	5	EBI-624252,EBI-624585
TDRD7	Q8NHU6	4	EBI-624237,EBI-624505
YEATS4	O95619	6	EBI-624237,EBI-399269

Alternative products

This entry describes 8 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: O75410-1)

Also known as: A; Long;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O75410-2)

Also known as: F;

The sequence of this isoform differs from the canonical sequence as follows:
     464-464: T → TTTEQVKFLCFLL

Isoform 3 (identifier: O75410-3)

Also known as: E;

The sequence of this isoform differs from the canonical sequence as follows:
     1-195: Missing.

Isoform 4 (identifier: O75410-4)

Also known as: D;

The sequence of this isoform differs from the canonical sequence as follows:
     1-426: Missing.
     427-464: DPFKPTTTLT...PKKAKSRLIT → MGGSHSQTPR...EQVKFLCFLL

Isoform 5 (identifier: O75410-5)

Also known as: C;

The sequence of this isoform differs from the canonical sequence as follows:
     1-438: Missing.
     439-464: DFCSPTGNHVNEILESPKKAKSRLIT → MGGSHSQTPRGREPAGERHPRPTETA

Isoform 6 (identifier: O75410-6)

Also known as: Short;

The sequence of this isoform differs from the canonical sequence as follows:
     54-54: S → R
     55-464: Missing.

Isoform 7 (identifier: O75410-7)

The sequence of this isoform differs from the canonical sequence as follows:
     1-41: Missing.
     42-53: EDSQAETKSLSF → MNNILKLK
     525-553: Missing.

Isoform 8 (identifier: O75410-8)

The sequence of this isoform differs from the canonical sequence as follows:
     1-651: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 805	805	Transforming acidic coiled-coil-containing protein 1		PRO_0000179986
Regions
	Domain	215 – 297	83	SPAZ 1
	Domain	359 – 507	149	SPAZ 2
	Region	1 – 55	55	Interaction with LSM7 and SNRPG
	Region	152 – 259	108	Interaction with TDRD7
	Region	206 – 427	222	Interaction with YEATS4
	Region	701 – 805	105	Interaction with CH-TOG
	Coiled coil	610 – 805	196
	Motif	226 – 241	16	Bipartite nuclear localization signal 1 Potential
	Motif	455 – 471	17	Bipartite nuclear localization signal 2 Potential
Amino acid modifications
	Modified residue	44	1	Phosphoserine Ref.18
	Modified residue	50	1	Phosphoserine Ref.17
	Modified residue	52	1	Phosphoserine Ref.17
	Modified residue	54	1	Phosphoserine Ref.17
	Modified residue	55	1	Phosphoserine Ref.17
	Modified residue	57	1	Phosphoserine Ref.17
	Modified residue	228	1	Phosphoserine; by AURKC Ref.19
	Modified residue	276	1	Phosphoserine Ref.20
	Modified residue	406	1	Phosphoserine By similarity
	Modified residue	533	1	Phosphotyrosine Ref.16
Natural variations
	Alternative sequence	1 – 651	651	Missing in isoform 8.		VSP_012640
	Alternative sequence	1 – 438	438	Missing in isoform 5.		VSP_012639
	Alternative sequence	1 – 426	426	Missing in isoform 4.		VSP_012641
	Alternative sequence	1 – 195	195	Missing in isoform 3.		VSP_012638
	Alternative sequence	1 – 41	41	Missing in isoform 7.		VSP_012637
	Alternative sequence	42 – 53	12	EDSQA…KSLSF → MNNILKLK in isoform 7.		VSP_012643
	Alternative sequence	54	1	S → R in isoform 6.		VSP_012644
	Alternative sequence	55 – 464	410	Missing in isoform 6.		VSP_012645
	Alternative sequence	427 – 464	38	DPFKP…SRLIT → MGGSHSQTPRGREPAGERHP RPTETATTEQVKFLCFLL in isoform 4.		VSP_012642
	Alternative sequence	439 – 464	26	DFCSP…SRLIT → MGGSHSQTPRGREPAGERHP RPTETA in isoform 5.		VSP_012646
	Alternative sequence	464	1	T → TTTEQVKFLCFLL in isoform 2.		VSP_012647
	Alternative sequence	525 – 553	29	Missing in isoform 7.		VSP_012648
	Natural variant	187	1	P → L. Corresponds to variant rs34235313 [ dbSNP | Ensembl ].		VAR_053703
	Natural variant	243	1	I → T. Corresponds to variant rs6980553 [ dbSNP | Ensembl ].		VAR_053704
	Natural variant	255	1	E → G. Corresponds to variant rs10107016 [ dbSNP | Ensembl ].		VAR_053705
Experimental info
	Mutagenesis	228	1	S → A: Impairs phosphorylation by AURKC. Ref.19
	Sequence conflict	291	1	L → I in AAC32327. Ref.1
	Sequence conflict	428	1	P → H in AAH41391. Ref.6
	Sequence conflict	588	1	G → V in BAA83055. Ref.7
	Sequence conflict	654	1	Missing in BAA83055. Ref.7

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (A) (Long) [UniParc]. Last modified February 1, 2005. Version 2. Checksum: 3A261EF58C165107	FASTA	805	87,794
	10 20 30 40 50 60 MAFSPWQILS PVQWAKWTWS AVRGGAAGED EAGGPEGDPE EEDSQAETKS LSFSSDSEGN 70 80 90 100 110 120 FETPEAETPI RSPFKESCDP SLGLAGPGAK SQESQEADEQ LVAEVVEKCS SKTCSKPSEN 130 140 150 160 170 180 EVPQQAIDSH SVKNFREEPE HDFSKISIVR PFSIETKDST DISAVLGTKA AHGCVTAVSG 190 200 210 220 230 240 KALPSSPPDA LQDEAMTEGS MGVTLEASAE ADLKAGNSCP ELVPSRRSKL RKPKPVPLRK 250 260 270 280 290 300 KAIGGEFSDT NAAVEGTPLP KASYHFSPEE LDENTSPLLG DARFQKSPPD LKETPGTLSS 310 320 330 340 350 360 DTNDSGVELG EESRSSPLKL EFDFTEDTGN IEARKALPRK LGRKLGSTLT PKIQKDGISK 370 380 390 400 410 420 SAGLEQPTDP VARDGPLSQT SSKPDPSQWE SPSFNPFGSH SVLQNSPPLS SEGSYHFDPD 430 440 450 460 470 480 NFDESMDPFK PTTTLTSSDF CSPTGNHVNE ILESPKKAKS RLITSGCKVK KHETQSLALD 490 500 510 520 530 540 ACSRDEGAVI SQISDISNRD GHATDEEKLA STSCGQKSAG AEVKGEPEED LEYFECSNVP 550 560 570 580 590 600 VSTINHAFSS SEAGIEKETC QKMEEDGSTV LGLLESSAEK APVSVSCGGE SPLDGICLSE 610 620 630 640 650 660 SDKTAVLTLI REEIITKEIE ANEWKKKYEE TRQEVLEMRK IVAEYEKTIA QMIEDEQRTS 670 680 690 700 710 720 MTSQKSFQQL TMEKEQALAD LNSVERSLSD LFRRYENLKG VLEGFKKNEE ALKKCAQDYL 730 740 750 760 770 780 ARVKQEEQRY QALKIHAEEK LDKANEEIAQ VRTKAKAESA ALHAGLRKEQ MKVESLERAL 790 800 QQKNQEIEEL TKICDELIAK LGKTD
	Isoform 2 (F) [UniParc]. Checksum: B9D4BDE7B742E813	FASTA	817	89,218
	10 20 30 40 50 60 MAFSPWQILS PVQWAKWTWS AVRGGAAGED EAGGPEGDPE EEDSQAETKS LSFSSDSEGN 70 80 90 100 110 120 FETPEAETPI RSPFKESCDP SLGLAGPGAK SQESQEADEQ LVAEVVEKCS SKTCSKPSEN 130 140 150 160 170 180 EVPQQAIDSH SVKNFREEPE HDFSKISIVR PFSIETKDST DISAVLGTKA AHGCVTAVSG 190 200 210 220 230 240 KALPSSPPDA LQDEAMTEGS MGVTLEASAE ADLKAGNSCP ELVPSRRSKL RKPKPVPLRK 250 260 270 280 290 300 KAIGGEFSDT NAAVEGTPLP KASYHFSPEE LDENTSPLLG DARFQKSPPD LKETPGTLSS 310 320 330 340 350 360 DTNDSGVELG EESRSSPLKL EFDFTEDTGN IEARKALPRK LGRKLGSTLT PKIQKDGISK 370 380 390 400 410 420 SAGLEQPTDP VARDGPLSQT SSKPDPSQWE SPSFNPFGSH SVLQNSPPLS SEGSYHFDPD 430 440 450 460 470 480 NFDESMDPFK PTTTLTSSDF CSPTGNHVNE ILESPKKAKS RLITTTEQVK FLCFLLSGCK 490 500 510 520 530 540 VKKHETQSLA LDACSRDEGA VISQISDISN RDGHATDEEK LASTSCGQKS AGAEVKGEPE 550 560 570 580 590 600 EDLEYFECSN VPVSTINHAF SSSEAGIEKE TCQKMEEDGS TVLGLLESSA EKAPVSVSCG 610 620 630 640 650 660 GESPLDGICL SESDKTAVLT LIREEIITKE IEANEWKKKY EETRQEVLEM RKIVAEYEKT 670 680 690 700 710 720 IAQMIEDEQR TSMTSQKSFQ QLTMEKEQAL ADLNSVERSL SDLFRRYENL KGVLEGFKKN 730 740 750 760 770 780 EEALKKCAQD YLARVKQEEQ RYQALKIHAE EKLDKANEEI AQVRTKAKAE SAALHAGLRK 790 800 810 EQMKVESLER ALQQKNQEIE ELTKICDELI AKLGKTD
	Isoform 3 (E) [UniParc]. Checksum: 802527D4B613A881	FASTA	610	67,073
	10 20 30 40 50 60 MTEGSMGVTL EASAEADLKA GNSCPELVPS RRSKLRKPKP VPLRKKAIGG EFSDTNAAVE 70 80 90 100 110 120 GTPLPKASYH FSPEELDENT SPLLGDARFQ KSPPDLKETP GTLSSDTNDS GVELGEESRS 130 140 150 160 170 180 SPLKLEFDFT EDTGNIEARK ALPRKLGRKL GSTLTPKIQK DGISKSAGLE QPTDPVARDG 190 200 210 220 230 240 PLSQTSSKPD PSQWESPSFN PFGSHSVLQN SPPLSSEGSY HFDPDNFDES MDPFKPTTTL 250 260 270 280 290 300 TSSDFCSPTG NHVNEILESP KKAKSRLITS GCKVKKHETQ SLALDACSRD EGAVISQISD 310 320 330 340 350 360 ISNRDGHATD EEKLASTSCG QKSAGAEVKG EPEEDLEYFE CSNVPVSTIN HAFSSSEAGI 370 380 390 400 410 420 EKETCQKMEE DGSTVLGLLE SSAEKAPVSV SCGGESPLDG ICLSESDKTA VLTLIREEII 430 440 450 460 470 480 TKEIEANEWK KKYEETRQEV LEMRKIVAEY EKTIAQMIED EQRTSMTSQK SFQQLTMEKE 490 500 510 520 530 540 QALADLNSVE RSLSDLFRRY ENLKGVLEGF KKNEEALKKC AQDYLARVKQ EEQRYQALKI 550 560 570 580 590 600 HAEEKLDKAN EEIAQVRTKA KAESAALHAG LRKEQMKVES LERALQQKNQ EIEELTKICD 610 ELIAKLGKTD
	Isoform 4 (D) [UniParc]. Checksum: A3CF1029DF65E860	FASTA	379	42,326
	10 20 30 40 50 60 MGGSHSQTPR GREPAGERHP RPTETATTEQ VKFLCFLLSG CKVKKHETQS LALDACSRDE 70 80 90 100 110 120 GAVISQISDI SNRDGHATDE EKLASTSCGQ KSAGAEVKGE PEEDLEYFEC SNVPVSTINH 130 140 150 160 170 180 AFSSSEAGIE KETCQKMEED GSTVLGLLES SAEKAPVSVS CGGESPLDGI CLSESDKTAV 190 200 210 220 230 240 LTLIREEIIT KEIEANEWKK KYEETRQEVL EMRKIVAEYE KTIAQMIEDE QRTSMTSQKS 250 260 270 280 290 300 FQQLTMEKEQ ALADLNSVER SLSDLFRRYE NLKGVLEGFK KNEEALKKCA QDYLARVKQE 310 320 330 340 350 360 EQRYQALKIH AEEKLDKANE EIAQVRTKAK AESAALHAGL RKEQMKVESL ERALQQKNQE 370 IEELTKICDE LIAKLGKTD
	Isoform 5 (C) [UniParc]. Checksum: F1761EA28D5AB9A8	FASTA	367	40,903
	10 20 30 40 50 60 MGGSHSQTPR GREPAGERHP RPTETASGCK VKKHETQSLA LDACSRDEGA VISQISDISN 70 80 90 100 110 120 RDGHATDEEK LASTSCGQKS AGAEVKGEPE EDLEYFECSN VPVSTINHAF SSSEAGIEKE 130 140 150 160 170 180 TCQKMEEDGS TVLGLLESSA EKAPVSVSCG GESPLDGICL SESDKTAVLT LIREEIITKE 190 200 210 220 230 240 IEANEWKKKY EETRQEVLEM RKIVAEYEKT IAQMIEDEQR TSMTSQKSFQ QLTMEKEQAL 250 260 270 280 290 300 ADLNSVERSL SDLFRRYENL KGVLEGFKKN EEALKKCAQD YLARVKQEEQ RYQALKIHAE 310 320 330 340 350 360 EKLDKANEEI AQVRTKAKAE SAALHAGLRK EQMKVESLER ALQQKNQEIE ELTKICDELI AKLGKTD
	Isoform 6 (Short) [UniParc]. Checksum: B29F0EA1DCAAF8E1	FASTA	395	43,984
	10 20 30 40 50 60 MAFSPWQILS PVQWAKWTWS AVRGGAAGED EAGGPEGDPE EEDSQAETKS LSFRSGCKVK 70 80 90 100 110 120 KHETQSLALD ACSRDEGAVI SQISDISNRD GHATDEEKLA STSCGQKSAG AEVKGEPEED 130 140 150 160 170 180 LEYFECSNVP VSTINHAFSS SEAGIEKETC QKMEEDGSTV LGLLESSAEK APVSVSCGGE 190 200 210 220 230 240 SPLDGICLSE SDKTAVLTLI REEIITKEIE ANEWKKKYEE TRQEVLEMRK IVAEYEKTIA 250 260 270 280 290 300 QMIEDEQRTS MTSQKSFQQL TMEKEQALAD LNSVERSLSD LFRRYENLKG VLEGFKKNEE 310 320 330 340 350 360 ALKKCAQDYL ARVKQEEQRY QALKIHAEEK LDKANEEIAQ VRTKAKAESA ALHAGLRKEQ 370 380 390 MKVESLERAL QQKNQEIEEL TKICDELIAK LGKTD
	Isoform 7 [UniParc]. Checksum: 385263AECC0C7060	FASTA	731	79,872
	10 20 30 40 50 60 MNNILKLKSS DSEGNFETPE AETPIRSPFK ESCDPSLGLA GPGAKSQESQ EADEQLVAEV 70 80 90 100 110 120 VEKCSSKTCS KPSENEVPQQ AIDSHSVKNF REEPEHDFSK ISIVRPFSIE TKDSTDISAV 130 140 150 160 170 180 LGTKAAHGCV TAVSGKALPS SPPDALQDEA MTEGSMGVTL EASAEADLKA GNSCPELVPS 190 200 210 220 230 240 RRSKLRKPKP VPLRKKAIGG EFSDTNAAVE GTPLPKASYH FSPEELDENT SPLLGDARFQ 250 260 270 280 290 300 KSPPDLKETP GTLSSDTNDS GVELGEESRS SPLKLEFDFT EDTGNIEARK ALPRKLGRKL 310 320 330 340 350 360 GSTLTPKIQK DGISKSAGLE QPTDPVARDG PLSQTSSKPD PSQWESPSFN PFGSHSVLQN 370 380 390 400 410 420 SPPLSSEGSY HFDPDNFDES MDPFKPTTTL TSSDFCSPTG NHVNEILESP KKAKSRLITS 430 440 450 460 470 480 GCKVKKHETQ SLALDACSRD EGAVISQISD ISNRDGHATD EEKLASTSCG QKSAGAEVKG 490 500 510 520 530 540 IEKETCQKME EDGSTVLGLL ESSAEKAPVS VSCGGESPLD GICLSESDKT AVLTLIREEI 550 560 570 580 590 600 ITKEIEANEW KKKYEETRQE VLEMRKIVAE YEKTIAQMIE DEQRTSMTSQ KSFQQLTMEK 610 620 630 640 650 660 EQALADLNSV ERSLSDLFRR YENLKGVLEG FKKNEEALKK CAQDYLARVK QEEQRYQALK 670 680 690 700 710 720 IHAEEKLDKA NEEIAQVRTK AKAESAALHA GLRKEQMKVE SLERALQQKN QEIEELTKIC 730 DELIAKLGKT D
	Isoform 8 [UniParc]. Checksum: F7CF945C5A3E277D	FASTA	154	17,815
	10 20 30 40 50 60 MIEDEQRTSM TSQKSFQQLT MEKEQALADL NSVERSLSDL FRRYENLKGV LEGFKKNEEA 70 80 90 100 110 120 LKKCAQDYLA RVKQEEQRYQ ALKIHAEEKL DKANEEIAQV RTKAKAESAA LHAGLRKEQM 130 140 150 KVESLERALQ QKNQEIEELT KICDELIAKL GKTD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of TACC1, an embryonically expressed, potentially transforming coiled coil containing gene, from the 8p11 breast cancer amplicon." Still I.H., Hamilton M., Vince P., Wolfman A., Cowell J.K. Oncogene 18:4032-4038(1999) [PubMed: 10435627] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Structure-function evolution of the transforming acidic coiled coil genes revealed by analysis of phylogenetically diverse organisms." Still I.H., Vettaikkorumakankauv A.K., DiMatteo A., Liang P. BMC Evol. Biol. 4:16-16(2004) [PubMed: 15207008] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 6).
[3]	"Cloning of a novel human gene similar to TACC1." Li F., Yao K.T. Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 8).
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Testis.
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7). Tissue: Brain.
[7]	"Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 6:197-205(1999) [PubMed: 10470851] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 364-805 (ISOFORM 2). Tissue: Brain.
[8]	"Serological identification and expression analysis of gastric cancer-associated genes." Line A., Stengrevics A., Slucka Z., Li G., Jankevics E., Rees R.C. Br. J. Cancer 86:1824-1830(2002) [PubMed: 12087473] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 450-805 (ISOFORM 2). Tissue: Gastric adenocarcinoma.
[9]	"Altered splicing pattern of TACC1 mRNA in gastric cancer." Line A., Slucka Z., Stengrevics A., Li G., Rees R.C. Cancer Genet. Cytogenet. 139:78-83(2002) [PubMed: 12547166] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-543 (ISOFORM 3), NUCLEOTIDE SEQUENCE OF 1-571 (ISOFORMS 4 AND 5), TISSUE SPECIFICITY. Tissue: Stomach cancer.
[10]	"The TACC domain identifies a family of centrosomal proteins that can interact with microtubules." Gergely F., Karlsson C., Still I.H., Cowell J.K., Kilmartin J., Raff J.W. Proc. Natl. Acad. Sci. U.S.A. 97:14352-14357(2000) [PubMed: 11121038] [Abstract] Cited for: CHARACTERIZATION. Tissue: Brain, Fetal brain and Skeletal muscle.
[11]	"Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells." Lauffart B., Howell S.J., Tasch J.E., Cowell J.K., Still I.H. Biochem. J. 363:195-200(2002) [PubMed: 11903063] [Abstract] Cited for: INTERACTION WITH KIAA0097 AND YEATS4.
[12]	"Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators." Conte N., Charafe-Jauffret E., Delaval B., Adelaide J., Ginestier C., Geneix J., Isnardon D., Jacquemier J., Birnbaum D. Oncogene 21:5619-5630(2002) [PubMed: 12165861] [Abstract] Cited for: INTERACTION WITH LSM7 AND SNRPG, TISSUE SPECIFICITY, PHOSPHORYLATION.
[13]	"TACC1-chTOG-Aurora A protein complex in breast cancer." Conte N., Delaval B., Ginestier C., Ferrand A., Isnardon D., Larroque C., Prigent C., Seraphin B., Jacquemier J., Birnbaum D. Oncogene 22:8102-8116(2003) [PubMed: 14603251] [Abstract] Cited for: INTERACTION WITH KIAA0097; LSM7; TDRD7 AND AURKA.
[14]	"The transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases." Gangisetty O., Lauffart B., Sondarva G.V., Chelsea D.M., Still I.H. Oncogene 23:2559-2563(2004) [PubMed: 14767476] [Abstract] Cited for: INTERACTION WITH GCN5L2 AND PCAF, SUBCELLULAR LOCATION.
[15]	"Aurora B -TACC1 protein complex in cytokinesis." Delaval B., Ferrand A., Conte N., Larroque C., Hernandez-Verdun D., Prigent C., Birnbaum D. Oncogene 23:4516-4522(2004) [PubMed: 15064709] [Abstract] Cited for: INTERACTION WITH AURKB.
[16]	"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells." Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J. Nat. Biotechnol. 23:94-101(2005) [PubMed: 15592455] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-533, MASS SPECTROMETRY.
[17]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50; SER-52; SER-54; SER-55 AND SER-57, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[18]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed: 17525332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-44, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[19]	"Aurora-C interacts with and phosphorylates the transforming acidic coiled-coil 1 protein." Gabillard J.C., Ulisse S., Baldini E., Sorrenti S., Cremet J.Y., Coccaro C., Prigent C., D'Armiento M., Arlot-Bonnemains Y. Biochem. Biophys. Res. Commun. 408:647-653(2011) [PubMed: 21531210] [Abstract] Cited for: SUBCELLULAR LOCATION, INTERACTION WITH AURKC, PHOSPHORYLATION AT SER-228 BY AURKC, MUTAGENESIS OF SER-228.
[20]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-276, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF049910 mRNA. Translation: AAC32327.1. AY177411 mRNA. Translation: AAO53446.1. AY139007 mRNA. Translation: AAN28955.1. AK314620 mRNA. Translation: BAG37186.1. CH471080 Genomic DNA. Translation: EAW63293.1. CH471080 Genomic DNA. Translation: EAW63296.1. CH471080 Genomic DNA. Translation: EAW63298.1. BC041391 mRNA. Translation: AAH41391.1. AB029026 mRNA. Translation: BAA83055.1. AY039239 mRNA. Translation: AAK68658.1. AY072874 mRNA. Translation: AAL62461.1. AY072875 mRNA. Translation: AAL62462.1. AY072876 mRNA. Translation: AAL62463.2.
IPI	IPI00025683. IPI00216765. IPI00332794. IPI00428263. IPI00549229. IPI00550248. IPI00550465. IPI00550627.
RefSeq	NP_001116296.1. NM_001122824.1. NP_001139688.1. NM_001146216.2. NP_006274.2. NM_006283.2.
UniGene	Hs.279245.
3D structure databases
ProteinModelPortal	O75410.
SMR	O75410. Positions 612-639, 756-792.
ModBase	Search...
Protein-protein interaction databases
IntAct	O75410. 20 interactions.
STRING	O75410.
PTM databases
PhosphoSite	O75410.
Proteomic databases
PRIDE	O75410.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000317827; ENSP00000321703; ENSG00000147526.
GeneID	6867.
KEGG	hsa:6867.
NMPDR	fig|9606.3.peg.30215.
UCSC	uc003xmb.2. human. uc003xmf.2. human. uc003xmh.2. human. uc010lwp.1. human. uc010lwq.1. human.
Organism-specific databases
CTD	6867.
GeneCards	GC08P038586.
H-InvDB	HIX0007462.
HGNC	HGNC:11522. TACC1.
HPA	CAB017041. HPA024702.
MIM	605301. gene.
neXtProt	NX_O75410.
PharmGKB	PA36299.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG14643.
GeneTree	ENSGT00530000063855.
HOVERGEN	HBG105967.
OMA	SSDTNDS.
PhylomeDB	O75410.
Enzyme and pathway databases
Pathway_Interaction_DB	aurora_a_pathway. Aurora A signaling. aurora_b_pathway. Aurora B signaling.
Gene expression databases
ArrayExpress	O75410.
Bgee	O75410.
Genevestigator	O75410.
GermOnline	ENSG00000147526. Homo sapiens.
Family and domain databases
InterPro	IPR007707. TACC. [Graphical view]
KO	K14281.
PANTHER	PTHR13924. TACC. 1 hit.
Pfam	PF05010. TACC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	26803.
PMAP-CutDB	O75410.
SOURCE	Search...

Entry information

Entry name

TACC1_HUMAN

Accession

Primary (citable) accession number: O75410
Secondary accession number(s): B2RBD9 , D3DSX6, Q6Y687, Q86YG7, Q8IUJ2, Q8IUJ3, Q8IUJ4, Q8IZG2, Q8NEY7, Q9UPP9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	February 1, 2005
Last modified:	January 25, 2012
This is version 109 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.