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O75410

- TACC1_HUMAN

UniProt

O75410 - TACC1_HUMAN

Protein

Transforming acidic coiled-coil-containing protein 1

Gene

TACC1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • Format
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    • History
      Entry version 136 (01 Oct 2014)
      Sequence version 2 (01 Feb 2005)
      Previous versions | rss
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    Functioni

    Likely involved in the processes that promote cell division prior to the formation of differentiated tissues.

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. cerebral cortex development Source: Ensembl
    4. interkinetic nuclear migration Source: Ensembl
    5. microtubule cytoskeleton organization Source: Ensembl
    6. neurogenesis Source: Ensembl
    7. regulation of microtubule-based process Source: Ensembl

    Keywords - Biological processi

    Cell cycle, Cell division

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transforming acidic coiled-coil-containing protein 1
    Alternative name(s):
    Gastric cancer antigen Ga55
    Taxin-1
    Gene namesi
    Name:TACC1
    Synonyms:KIAA1103
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:11522. TACC1.

    Subcellular locationi

    Cytoplasm. Nucleus. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome
    Note: Nucleus during interphase. Weakly concentrated at centrosomes during mitosis and colocalizes with AURKC at the midbody during cytokinesis.

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. intermediate filament cytoskeleton Source: HPA
    3. microtubule cytoskeleton Source: HPA
    4. microtubule organizing center Source: UniProtKB-SubCell
    5. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi228 – 2281S → A: Impairs phosphorylation by AURKC. 1 Publication

    Organism-specific databases

    Orphaneti251579. Giant cell glioblastoma.
    251576. Gliosarcoma.
    PharmGKBiPA36299.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 805804Transforming acidic coiled-coil-containing protein 1PRO_0000179986Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication
    Modified residuei4 – 41Phosphoserine2 Publications
    Modified residuei10 – 101Phosphoserine2 Publications
    Modified residuei228 – 2281Phosphoserine; by AURKC2 Publications
    Modified residuei276 – 2761Phosphoserine2 Publications
    Modified residuei381 – 3811PhosphoserineBy similarity
    Modified residuei533 – 5331Phosphotyrosine2 Publications

    Post-translational modificationi

    Isoform 1 is heavily phosphorylated; isoform 6 is not.5 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiO75410.
    PaxDbiO75410.
    PRIDEiO75410.

    PTM databases

    PhosphoSiteiO75410.

    Miscellaneous databases

    PMAP-CutDBO75410.

    Expressioni

    Tissue specificityi

    Isoform 1, isoform 3 and isoform 5 are ubiquitous. Isoform 2 is strongly expressed in the brain, weakly detectable in lung and colon, and overexpressed in gastric cancer. Isoform 4 is not detected in normal tissues, but strong expression was found in gastric cancer tissues. Down-regulated in a subset of cases of breast cancer.2 Publications

    Developmental stagei

    Expressed at high level during early embryogenesis.

    Gene expression databases

    ArrayExpressiO75410.
    BgeeiO75410.
    GenevestigatoriO75410.

    Organism-specific databases

    HPAiCAB017041.
    HPA024702.

    Interactioni

    Subunit structurei

    Interacts with KIAA0097/CH-TOG and with the oncogenic transcription factor YEATS4. Interacts with AURKA, AURKB and AURKC. Interacts with LSM7, TDRD7 and SNRPG. Interacts with GCN5L2 and PCAF.6 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    AURKBQ96GD42EBI-624278,EBI-624291
    CKAP5Q140083EBI-624252,EBI-310585
    HTTP428584EBI-624237,EBI-466029
    LSM7Q9UK454EBI-624252,EBI-348372
    SNRPGP623085EBI-624252,EBI-624585
    TDRD7Q8NHU64EBI-624237,EBI-624505
    YEATS4O956196EBI-624237,EBI-399269

    Protein-protein interaction databases

    BioGridi112730. 18 interactions.
    IntActiO75410. 13 interactions.
    MINTiMINT-8417725.

    Structurei

    3D structure databases

    ProteinModelPortaliO75410.
    SMRiO75410. Positions 605-651.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini215 – 29783SPAZ 1Add
    BLAST
    Domaini359 – 507149SPAZ 2Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni2 – 5554Interaction with LSM7 and SNRPGAdd
    BLAST
    Regioni152 – 259108Interaction with TDRD7Add
    BLAST
    Regioni206 – 427222Interaction with YEATS4Add
    BLAST
    Regioni701 – 805105Interaction with CH-TOGAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili610 – 805196Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi226 – 24116Bipartite nuclear localization signal 1Sequence AnalysisAdd
    BLAST
    Motifi455 – 47117Bipartite nuclear localization signal 2Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TACC family.Curated

    Keywords - Domaini

    Coiled coil, Repeat

    Phylogenomic databases

    eggNOGiNOG83363.
    HOVERGENiHBG105967.
    KOiK14281.
    OMAiSFQQLTM.
    PhylomeDBiO75410.
    TreeFamiTF333149.

    Family and domain databases

    InterProiIPR007707. TACC.
    [Graphical view]
    PANTHERiPTHR13924. PTHR13924. 1 hit.
    PfamiPF05010. TACC. 1 hit.
    [Graphical view]

    Sequences (8)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 8 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform 1 (identifier: O75410-1) [UniParc]FASTAAdd to Basket

    Also known as: A, Long

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAFSPWQILS PVQWAKWTWS AVRGGAAGED EAGGPEGDPE EEDSQAETKS    50
    LSFSSDSEGN FETPEAETPI RSPFKESCDP SLGLAGPGAK SQESQEADEQ 100
    LVAEVVEKCS SKTCSKPSEN EVPQQAIDSH SVKNFREEPE HDFSKISIVR 150
    PFSIETKDST DISAVLGTKA AHGCVTAVSG KALPSSPPDA LQDEAMTEGS 200
    MGVTLEASAE ADLKAGNSCP ELVPSRRSKL RKPKPVPLRK KAIGGEFSDT 250
    NAAVEGTPLP KASYHFSPEE LDENTSPLLG DARFQKSPPD LKETPGTLSS 300
    DTNDSGVELG EESRSSPLKL EFDFTEDTGN IEARKALPRK LGRKLGSTLT 350
    PKIQKDGISK SAGLEQPTDP VARDGPLSQT SSKPDPSQWE SPSFNPFGSH 400
    SVLQNSPPLS SEGSYHFDPD NFDESMDPFK PTTTLTSSDF CSPTGNHVNE 450
    ILESPKKAKS RLITSGCKVK KHETQSLALD ACSRDEGAVI SQISDISNRD 500
    GHATDEEKLA STSCGQKSAG AEVKGEPEED LEYFECSNVP VSTINHAFSS 550
    SEAGIEKETC QKMEEDGSTV LGLLESSAEK APVSVSCGGE SPLDGICLSE 600
    SDKTAVLTLI REEIITKEIE ANEWKKKYEE TRQEVLEMRK IVAEYEKTIA 650
    QMIEDEQRTS MTSQKSFQQL TMEKEQALAD LNSVERSLSD LFRRYENLKG 700
    VLEGFKKNEE ALKKCAQDYL ARVKQEEQRY QALKIHAEEK LDKANEEIAQ 750
    VRTKAKAESA ALHAGLRKEQ MKVESLERAL QQKNQEIEEL TKICDELIAK 800
    LGKTD 805
    Length:805
    Mass (Da):87,794
    Last modified:February 1, 2005 - v2
    Checksum:i3A261EF58C165107
    GO
    Isoform 2 (identifier: O75410-2) [UniParc]FASTAAdd to Basket

    Also known as: F

    The sequence of this isoform differs from the canonical sequence as follows:
         464-464: T → TTTEQVKFLCFLL

    Show »
    Length:817
    Mass (Da):89,218
    Checksum:iB9D4BDE7B742E813
    GO
    Isoform 3 (identifier: O75410-3) [UniParc]FASTAAdd to Basket

    Also known as: E

    The sequence of this isoform differs from the canonical sequence as follows:
         1-195: Missing.

    Show »
    Length:610
    Mass (Da):67,073
    Checksum:i802527D4B613A881
    GO
    Isoform 4 (identifier: O75410-4) [UniParc]FASTAAdd to Basket

    Also known as: D

    The sequence of this isoform differs from the canonical sequence as follows:
         1-426: Missing.
         427-464: DPFKPTTTLT...PKKAKSRLIT → MGGSHSQTPR...EQVKFLCFLL

    Show »
    Length:379
    Mass (Da):42,326
    Checksum:iA3CF1029DF65E860
    GO
    Isoform 5 (identifier: O75410-5) [UniParc]FASTAAdd to Basket

    Also known as: C

    The sequence of this isoform differs from the canonical sequence as follows:
         1-438: Missing.
         439-464: DFCSPTGNHVNEILESPKKAKSRLIT → MGGSHSQTPRGREPAGERHPRPTETA

    Show »
    Length:367
    Mass (Da):40,903
    Checksum:iF1761EA28D5AB9A8
    GO
    Isoform 6 (identifier: O75410-6) [UniParc]FASTAAdd to Basket

    Also known as: Short

    The sequence of this isoform differs from the canonical sequence as follows:
         54-54: S → R
         55-464: Missing.

    Show »
    Length:395
    Mass (Da):43,984
    Checksum:iB29F0EA1DCAAF8E1
    GO
    Isoform 7 (identifier: O75410-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-41: Missing.
         42-53: EDSQAETKSLSF → MNNILKLK
         525-553: Missing.

    Show »
    Length:731
    Mass (Da):79,872
    Checksum:i385263AECC0C7060
    GO
    Isoform 8 (identifier: O75410-8) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-651: Missing.

    Show »
    Length:154
    Mass (Da):17,815
    Checksum:iF7CF945C5A3E277D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti291 – 2911L → I in AAC32327. (PubMed:10435627)Curated
    Sequence conflicti428 – 4281P → H in AAH41391. (PubMed:15489334)Curated
    Sequence conflicti588 – 5881G → V in BAA83055. (PubMed:10470851)Curated
    Sequence conflicti654 – 6541Missing in BAA83055. (PubMed:10470851)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti187 – 1871P → L.
    Corresponds to variant rs34235313 [ dbSNP | Ensembl ].
    VAR_053703
    Natural varianti243 – 2431I → T.
    Corresponds to variant rs6980553 [ dbSNP | Ensembl ].
    VAR_053704
    Natural varianti255 – 2551E → G.
    Corresponds to variant rs10107016 [ dbSNP | Ensembl ].
    VAR_053705

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 651651Missing in isoform 8. 1 PublicationVSP_012640Add
    BLAST
    Alternative sequencei1 – 438438Missing in isoform 5. CuratedVSP_012639Add
    BLAST
    Alternative sequencei1 – 426426Missing in isoform 4. CuratedVSP_012641Add
    BLAST
    Alternative sequencei1 – 195195Missing in isoform 3. 1 PublicationVSP_012638Add
    BLAST
    Alternative sequencei1 – 4141Missing in isoform 7. 1 PublicationVSP_012637Add
    BLAST
    Alternative sequencei42 – 5312EDSQA…KSLSF → MNNILKLK in isoform 7. 1 PublicationVSP_012643Add
    BLAST
    Alternative sequencei54 – 541S → R in isoform 6. 1 PublicationVSP_012644
    Alternative sequencei55 – 464410Missing in isoform 6. 1 PublicationVSP_012645Add
    BLAST
    Alternative sequencei427 – 46438DPFKP…SRLIT → MGGSHSQTPRGREPAGERHP RPTETATTEQVKFLCFLL in isoform 4. CuratedVSP_012642Add
    BLAST
    Alternative sequencei439 – 46426DFCSP…SRLIT → MGGSHSQTPRGREPAGERHP RPTETA in isoform 5. CuratedVSP_012646Add
    BLAST
    Alternative sequencei464 – 4641T → TTTEQVKFLCFLL in isoform 2. 2 PublicationsVSP_012647
    Alternative sequencei525 – 55329Missing in isoform 7. 1 PublicationVSP_012648Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF049910 mRNA. Translation: AAC32327.1.
    AY177411 mRNA. Translation: AAO53446.1.
    AY139007 mRNA. Translation: AAN28955.1.
    AK314620 mRNA. Translation: BAG37186.1.
    CH471080 Genomic DNA. Translation: EAW63293.1.
    CH471080 Genomic DNA. Translation: EAW63296.1.
    CH471080 Genomic DNA. Translation: EAW63298.1.
    BC041391 mRNA. Translation: AAH41391.1.
    AB029026 mRNA. Translation: BAA83055.1.
    AY039239 mRNA. Translation: AAK68658.1.
    AY072874 mRNA. Translation: AAL62461.1.
    AY072875 mRNA. Translation: AAL62462.1.
    AY072876 mRNA. Translation: AAL62463.2.
    CCDSiCCDS47845.1. [O75410-6]
    CCDS55224.1. [O75410-3]
    CCDS6109.1. [O75410-1]
    RefSeqiNP_001116296.1. NM_001122824.1. [O75410-6]
    NP_001139688.1. NM_001146216.2. [O75410-3]
    NP_006274.2. NM_006283.2. [O75410-1]
    XP_005273682.1. XM_005273625.2. [O75410-2]
    UniGeneiHs.279245.

    Genome annotation databases

    EnsembliENST00000276520; ENSP00000276520; ENSG00000147526. [O75410-6]
    ENST00000317827; ENSP00000321703; ENSG00000147526. [O75410-1]
    ENST00000518415; ENSP00000428706; ENSG00000147526. [O75410-7]
    ENST00000520615; ENSP00000428450; ENSG00000147526. [O75410-3]
    ENST00000521050; ENSP00000428949; ENSG00000147526.
    ENST00000521642; ENSP00000428466; ENSG00000147526.
    GeneIDi6867.
    KEGGihsa:6867.
    UCSCiuc003xlz.3. human. [O75410-1]
    uc003xma.3. human. [O75410-5]
    uc003xmb.4. human. [O75410-7]
    uc003xmf.4. human. [O75410-6]
    uc003xmh.4. human. [O75410-2]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF049910 mRNA. Translation: AAC32327.1 .
    AY177411 mRNA. Translation: AAO53446.1 .
    AY139007 mRNA. Translation: AAN28955.1 .
    AK314620 mRNA. Translation: BAG37186.1 .
    CH471080 Genomic DNA. Translation: EAW63293.1 .
    CH471080 Genomic DNA. Translation: EAW63296.1 .
    CH471080 Genomic DNA. Translation: EAW63298.1 .
    BC041391 mRNA. Translation: AAH41391.1 .
    AB029026 mRNA. Translation: BAA83055.1 .
    AY039239 mRNA. Translation: AAK68658.1 .
    AY072874 mRNA. Translation: AAL62461.1 .
    AY072875 mRNA. Translation: AAL62462.1 .
    AY072876 mRNA. Translation: AAL62463.2 .
    CCDSi CCDS47845.1. [O75410-6 ]
    CCDS55224.1. [O75410-3 ]
    CCDS6109.1. [O75410-1 ]
    RefSeqi NP_001116296.1. NM_001122824.1. [O75410-6 ]
    NP_001139688.1. NM_001146216.2. [O75410-3 ]
    NP_006274.2. NM_006283.2. [O75410-1 ]
    XP_005273682.1. XM_005273625.2. [O75410-2 ]
    UniGenei Hs.279245.

    3D structure databases

    ProteinModelPortali O75410.
    SMRi O75410. Positions 605-651.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112730. 18 interactions.
    IntActi O75410. 13 interactions.
    MINTi MINT-8417725.

    PTM databases

    PhosphoSitei O75410.

    Proteomic databases

    MaxQBi O75410.
    PaxDbi O75410.
    PRIDEi O75410.

    Protocols and materials databases

    DNASUi 6867.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000276520 ; ENSP00000276520 ; ENSG00000147526 . [O75410-6 ]
    ENST00000317827 ; ENSP00000321703 ; ENSG00000147526 . [O75410-1 ]
    ENST00000518415 ; ENSP00000428706 ; ENSG00000147526 . [O75410-7 ]
    ENST00000520615 ; ENSP00000428450 ; ENSG00000147526 . [O75410-3 ]
    ENST00000521050 ; ENSP00000428949 ; ENSG00000147526 .
    ENST00000521642 ; ENSP00000428466 ; ENSG00000147526 .
    GeneIDi 6867.
    KEGGi hsa:6867.
    UCSCi uc003xlz.3. human. [O75410-1 ]
    uc003xma.3. human. [O75410-5 ]
    uc003xmb.4. human. [O75410-7 ]
    uc003xmf.4. human. [O75410-6 ]
    uc003xmh.4. human. [O75410-2 ]

    Organism-specific databases

    CTDi 6867.
    GeneCardsi GC08P038586.
    H-InvDB HIX0007462.
    HGNCi HGNC:11522. TACC1.
    HPAi CAB017041.
    HPA024702.
    MIMi 605301. gene.
    neXtProti NX_O75410.
    Orphaneti 251579. Giant cell glioblastoma.
    251576. Gliosarcoma.
    PharmGKBi PA36299.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG83363.
    HOVERGENi HBG105967.
    KOi K14281.
    OMAi SFQQLTM.
    PhylomeDBi O75410.
    TreeFami TF333149.

    Miscellaneous databases

    ChiTaRSi TACC1. human.
    GeneWikii TACC1.
    GenomeRNAii 6867.
    NextBioi 26803.
    PMAP-CutDB O75410.
    PROi O75410.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O75410.
    Bgeei O75410.
    Genevestigatori O75410.

    Family and domain databases

    InterProi IPR007707. TACC.
    [Graphical view ]
    PANTHERi PTHR13924. PTHR13924. 1 hit.
    Pfami PF05010. TACC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of TACC1, an embryonically expressed, potentially transforming coiled coil containing gene, from the 8p11 breast cancer amplicon."
      Still I.H., Hamilton M., Vince P., Wolfman A., Cowell J.K.
      Oncogene 18:4032-4038(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Structure-function evolution of the transforming acidic coiled coil genes revealed by analysis of phylogenetically diverse organisms."
      Still I.H., Vettaikkorumakankauv A.K., DiMatteo A., Liang P.
      BMC Evol. Biol. 4:16-16(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 6).
    3. "Cloning of a novel human gene similar to TACC1."
      Li F., Yao K.T.
      Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 8).
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7).
      Tissue: Brain.
    7. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 364-805 (ISOFORM 2).
      Tissue: Brain.
    8. "Serological identification and expression analysis of gastric cancer-associated genes."
      Line A., Stengrevics A., Slucka Z., Li G., Jankevics E., Rees R.C.
      Br. J. Cancer 86:1824-1830(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 450-805 (ISOFORM 2).
      Tissue: Gastric adenocarcinoma.
    9. "Altered splicing pattern of TACC1 mRNA in gastric cancer."
      Line A., Slucka Z., Stengrevics A., Li G., Rees R.C.
      Cancer Genet. Cytogenet. 139:78-83(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-543 (ISOFORM 3), NUCLEOTIDE SEQUENCE OF 1-571 (ISOFORMS 4 AND 5), TISSUE SPECIFICITY.
      Tissue: Stomach cancer.
    10. "The TACC domain identifies a family of centrosomal proteins that can interact with microtubules."
      Gergely F., Karlsson C., Still I.H., Cowell J.K., Kilmartin J., Raff J.W.
      Proc. Natl. Acad. Sci. U.S.A. 97:14352-14357(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
      Tissue: Brain, Fetal brain and Skeletal muscle.
    11. "Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells."
      Lauffart B., Howell S.J., Tasch J.E., Cowell J.K., Still I.H.
      Biochem. J. 363:195-200(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH KIAA0097 AND YEATS4.
    12. "Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators."
      Conte N., Charafe-Jauffret E., Delaval B., Adelaide J., Ginestier C., Geneix J., Isnardon D., Jacquemier J., Birnbaum D.
      Oncogene 21:5619-5630(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH LSM7 AND SNRPG, TISSUE SPECIFICITY, PHOSPHORYLATION.
    13. Cited for: INTERACTION WITH KIAA0097; LSM7; TDRD7 AND AURKA.
    14. "The transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases."
      Gangisetty O., Lauffart B., Sondarva G.V., Chelsea D.M., Still I.H.
      Oncogene 23:2559-2563(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH GCN5L2 AND PCAF, SUBCELLULAR LOCATION.
    15. Cited for: INTERACTION WITH AURKB.
    16. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
      Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
      Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-533, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    17. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    18. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.
    19. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    20. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-276, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    21. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4 AND SER-10, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    22. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    23. Cited for: SUBCELLULAR LOCATION, INTERACTION WITH AURKC, PHOSPHORYLATION AT SER-228 BY AURKC, MUTAGENESIS OF SER-228.

    Entry informationi

    Entry nameiTACC1_HUMAN
    AccessioniPrimary (citable) accession number: O75410
    Secondary accession number(s): B2RBD9
    , D3DSX6, Q6Y687, Q86YG7, Q8IUJ2, Q8IUJ3, Q8IUJ4, Q8IZG2, Q8NEY7, Q9UPP9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: February 1, 2005
    Last modified: October 1, 2014
    This is version 136 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3