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Protein

Huntingtin-interacting protein M

Gene

HYPM

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Huntingtin-interacting protein M
Alternative name(s):
Huntingtin yeast partner M
Gene namesi
Name:HYPM
Synonyms:CXorf27
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:18417. HYPM.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134943086.

Polymorphism and mutation databases

BioMutaiCXorf27.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 117117Huntingtin-interacting protein MPRO_0000254087Add
BLAST

Proteomic databases

PaxDbiO75409.
PRIDEiO75409.

PTM databases

PhosphoSiteiO75409.

Expressioni

Gene expression databases

BgeeiO75409.
CleanExiHS_CXorf27.
GenevisibleiO75409. HS.

Organism-specific databases

HPAiHPA003356.

Interactioni

Subunit structurei

May interact with the N-terminus of HD.

Binary interactionsi

WithEntry#Exp.IntActNotes
CEP44Q9C0F13EBI-6447217,EBI-744115
MYOGP151733EBI-6447217,EBI-3906629

Protein-protein interaction databases

BioGridi117303. 5 interactions.
IntActiO75409. 5 interactions.
MINTiMINT-1537659.
STRINGi9606.ENSP00000339511.

Structurei

3D structure databases

ProteinModelPortaliO75409.
SMRiO75409. Positions 15-104.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410JF0T. Eukaryota.
ENOG4111B94. LUCA.
GeneTreeiENSGT00390000015623.
HOGENOMiHOG000234652.
HOVERGENiHBG095521.
InParanoidiO75409.
OMAiLDCLADY.
OrthoDBiEOG71ZP49.
PhylomeDBiO75409.
TreeFamiTF338397.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.

Sequencei

Sequence statusi: Complete.

O75409-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEKKNCKNS STNNNQTQDP SRNELQVPRS FVDRVVQDER DVQSQSSSTI
60 70 80 90 100
NTLLTLLDCL ADYIMERVGL EASNNGSMRN TSQDREREVD NNREPHSAES
110
DVTRFLFDEM PKSRKND
Length:117
Mass (Da):13,442
Last modified:October 31, 2006 - v2
Checksum:i0F73DE715C55BBF8
GO

Sequence cautioni

The sequence AAC26851.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti68 – 681V → I.
Corresponds to variant rs6651635 [ dbSNP | Ensembl ].
VAR_028810

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF049615 mRNA. Translation: AAC26851.1. Different initiation.
CH471141 Genomic DNA. Translation: EAW59451.1.
BC104428 mRNA. Translation: AAI04429.1.
BC104429 mRNA. Translation: AAI04430.1.
BC113024 mRNA. Translation: AAI13025.1.
BC113025 mRNA. Translation: AAI13026.1.
CCDSiCCDS43929.1.
RefSeqiNP_036406.1. NM_012274.1.
UniGeneiHs.122959.

Genome annotation databases

EnsembliENST00000341016; ENSP00000339511; ENSG00000187516.
GeneIDi25763.
KEGGihsa:25763.
UCSCiuc004ddt.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF049615 mRNA. Translation: AAC26851.1. Different initiation.
CH471141 Genomic DNA. Translation: EAW59451.1.
BC104428 mRNA. Translation: AAI04429.1.
BC104429 mRNA. Translation: AAI04430.1.
BC113024 mRNA. Translation: AAI13025.1.
BC113025 mRNA. Translation: AAI13026.1.
CCDSiCCDS43929.1.
RefSeqiNP_036406.1. NM_012274.1.
UniGeneiHs.122959.

3D structure databases

ProteinModelPortaliO75409.
SMRiO75409. Positions 15-104.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117303. 5 interactions.
IntActiO75409. 5 interactions.
MINTiMINT-1537659.
STRINGi9606.ENSP00000339511.

PTM databases

PhosphoSiteiO75409.

Polymorphism and mutation databases

BioMutaiCXorf27.

Proteomic databases

PaxDbiO75409.
PRIDEiO75409.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341016; ENSP00000339511; ENSG00000187516.
GeneIDi25763.
KEGGihsa:25763.
UCSCiuc004ddt.4. human.

Organism-specific databases

CTDi25763.
GeneCardsiHYPM.
HGNCiHGNC:18417. HYPM.
HPAiHPA003356.
neXtProtiNX_O75409.
PharmGKBiPA134943086.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JF0T. Eukaryota.
ENOG4111B94. LUCA.
GeneTreeiENSGT00390000015623.
HOGENOMiHOG000234652.
HOVERGENiHBG095521.
InParanoidiO75409.
OMAiLDCLADY.
OrthoDBiEOG71ZP49.
PhylomeDBiO75409.
TreeFamiTF338397.

Miscellaneous databases

GenomeRNAii25763.
NextBioi46876.
PROiO75409.

Gene expression databases

BgeeiO75409.
CleanExiHS_CXorf27.
GenevisibleiO75409. HS.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], POSSIBLE INTERACTION WITH HD.
    Tissue: Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiHYPM_HUMAN
AccessioniPrimary (citable) accession number: O75409
Secondary accession number(s): A1A4D3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: February 17, 2016
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.