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Protein

Vesicle-trafficking protein SEC22b

Gene

SEC22B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciZFISH:G66-30837-MONOMER.
ReactomeiR-HSA-1236974. ER-Phagosome pathway.
R-HSA-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-HSA-5694530. Cargo concentration in the ER.
R-HSA-6811434. COPI-dependent Golgi-to-ER retrograde traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicle-trafficking protein SEC22b
Alternative name(s):
ER-Golgi SNARE of 24 kDa
Short name:
ERS-24
Short name:
ERS24
SEC22 vesicle-trafficking protein homolog B
SEC22 vesicle-trafficking protein-like 1
Gene namesi
Name:SEC22B
Synonyms:SEC22L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:10700. SEC22B.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 194CytoplasmicSequence analysisAdd BLAST193
Transmembranei195 – 215Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35623.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00002067702 – 215Vesicle-trafficking protein SEC22bAdd BLAST214

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei38N6-acetyllysineCombined sources1
Modified residuei137PhosphoserineCombined sources1
Modified residuei140PhosphothreonineCombined sources1
Modified residuei164PhosphoserineCombined sources1
Modified residuei168PhosphoserineCombined sources1
Modified residuei174PhosphoserineCombined sources1
Modified residuei177PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO75396.
MaxQBiO75396.
PeptideAtlasiO75396.
PRIDEiO75396.
TopDownProteomicsiO75396.

PTM databases

iPTMnetiO75396.
PhosphoSitePlusiO75396.
SwissPalmiO75396.

Expressioni

Gene expression databases

CleanExiHS_SEC22B.
ExpressionAtlasiO75396. baseline and differential.
GenevisibleiO75396. HS.

Interactioni

Subunit structurei

Interacts with STX17 (By similarity). Component of two distinct SNARE complexes consisting of STX5, GOSR2/BOS1, BET1 and SEC22B or STX18, USE1L, BNIP1/SEC20L and SEC22B. YKT6 can probably replace SEC22B in either complex.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
STX18Q9P2W92EBI-1058865,EBI-725334
STX4Q128463EBI-1058865,EBI-744942

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114926. 90 interactors.
DIPiDIP-50458N.
IntActiO75396. 45 interactors.
MINTiMINT-5000824.

Structurei

Secondary structure

1215
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 9Combined sources5
Turni10 – 12Combined sources3
Beta strandi15 – 19Combined sources5
Helixi30 – 43Combined sources14
Beta strandi50 – 56Combined sources7
Beta strandi59 – 66Combined sources8
Beta strandi69 – 76Combined sources8
Helixi81 – 99Combined sources19
Turni100 – 105Combined sources6
Turni109 – 112Combined sources4
Helixi113 – 115Combined sources3
Helixi116 – 123Combined sources8
Turni124 – 126Combined sources3
Turni129 – 131Combined sources3
Beta strandi150 – 152Combined sources3
Helixi153 – 156Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2NUPX-ray2.80C1-195[»]
2NUTX-ray2.30C1-195[»]
3EGDX-ray2.70C1-157[»]
3EGXX-ray3.30C1-157[»]
ProteinModelPortaliO75396.
SMRiO75396.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO75396.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 119LonginPROSITE-ProRule annotationAdd BLAST114
Domaini134 – 194v-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST61

Sequence similaritiesi

Belongs to the synaptobrevin family.Curated
Contains 1 longin domain.PROSITE-ProRule annotation
Contains 1 v-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG052748.
InParanoidiO75396.
KOiK08517.
OrthoDBiEOG091G0MPE.
PhylomeDBiO75396.

Family and domain databases

Gene3Di1.10.3840.10. 1 hit.
3.30.450.50. 1 hit.
InterProiIPR011012. Longin-like_dom.
IPR010908. Longin_dom.
IPR001388. Synaptobrevin.
[Graphical view]
PfamiPF13774. Longin. 1 hit.
PF00957. Synaptobrevin. 1 hit.
[Graphical view]
PRINTSiPR00219. SYNAPTOBREVN.
SMARTiSM01270. Longin. 1 hit.
[Graphical view]
SUPFAMiSSF64356. SSF64356. 1 hit.
PROSITEiPS50859. LONGIN. 1 hit.
PS50892. V_SNARE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O75396-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLLTMIARV ADGLPLAASM QEDEQSGRDL QQYQSQAKQL FRKLNEQSPT
60 70 80 90 100
RCTLEAGAMT FHYIIEQGVC DLVLCEAAFP KTLAFAYLED LHSEFDEQHG
110 120 130 140 150
KKVPTVSRPY SFIEFDTFIQ KTKKLYIDSC ARRNLGSINT ELQDVQRIMV
160 170 180 190 200
ANIEEVLQRG EALSALDSKA NNLSSLSKKY RQDAKYLNMH STYAKLAAVA
210
VFFIMLIVYV RFWWL
Length:215
Mass (Da):24,593
Last modified:January 11, 2011 - v4
Checksum:i9FA59C20F2D3F690
GO

Sequence cautioni

The sequence AL359758 differs from that shown. Reason: Erroneous termination at position 39. Translated as Gln.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06031171D → Y.3 PublicationsCorresponds to variant rs2596331dbSNPEnsembl.1
Natural variantiVAR_06031282T → K.3 PublicationsCorresponds to variant rs2794053dbSNPEnsembl.1
Natural variantiVAR_057343108R → Q.Corresponds to variant rs2655551dbSNPEnsembl.1
Natural variantiVAR_060313130C → R.Combined sources3 PublicationsCorresponds to variant rs2590131dbSNPEnsembl.1
Natural variantiVAR_060314190H → R.3 PublicationsCorresponds to variant rs2655557dbSNPEnsembl.1
Natural variantiVAR_057344214W → C.Corresponds to variant rs7534444dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047442 mRNA. Translation: AAC39893.1.
AK289875 mRNA. Translation: BAF82564.1.
AL359758 Genomic DNA. No translation available.
BX537145 Genomic DNA. No translation available.
BC001364 mRNA. Translation: AAH01364.1.
RefSeqiNP_004883.3. NM_004892.5.
UniGeneiHs.632438.
Hs.661819.

Genome annotation databases

EnsembliENST00000578049; ENSP00000463393; ENSG00000265808.
GeneIDi9554.
KEGGihsa:9554.
UCSCiuc031unv.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047442 mRNA. Translation: AAC39893.1.
AK289875 mRNA. Translation: BAF82564.1.
AL359758 Genomic DNA. No translation available.
BX537145 Genomic DNA. No translation available.
BC001364 mRNA. Translation: AAH01364.1.
RefSeqiNP_004883.3. NM_004892.5.
UniGeneiHs.632438.
Hs.661819.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2NUPX-ray2.80C1-195[»]
2NUTX-ray2.30C1-195[»]
3EGDX-ray2.70C1-157[»]
3EGXX-ray3.30C1-157[»]
ProteinModelPortaliO75396.
SMRiO75396.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114926. 90 interactors.
DIPiDIP-50458N.
IntActiO75396. 45 interactors.
MINTiMINT-5000824.

PTM databases

iPTMnetiO75396.
PhosphoSitePlusiO75396.
SwissPalmiO75396.

Proteomic databases

EPDiO75396.
MaxQBiO75396.
PeptideAtlasiO75396.
PRIDEiO75396.
TopDownProteomicsiO75396.

Protocols and materials databases

DNASUi9554.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000578049; ENSP00000463393; ENSG00000265808.
GeneIDi9554.
KEGGihsa:9554.
UCSCiuc031unv.2. human.

Organism-specific databases

CTDi9554.
GeneCardsiSEC22B.
HGNCiHGNC:10700. SEC22B.
MIMi604029. gene.
neXtProtiNX_O75396.
PharmGKBiPA35623.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG052748.
InParanoidiO75396.
KOiK08517.
OrthoDBiEOG091G0MPE.
PhylomeDBiO75396.

Enzyme and pathway databases

BioCyciZFISH:G66-30837-MONOMER.
ReactomeiR-HSA-1236974. ER-Phagosome pathway.
R-HSA-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-HSA-5694530. Cargo concentration in the ER.
R-HSA-6811434. COPI-dependent Golgi-to-ER retrograde traffic.

Miscellaneous databases

EvolutionaryTraceiO75396.
GeneWikiiSEC22B.
GenomeRNAii9554.
PROiO75396.
SOURCEiSearch...

Gene expression databases

CleanExiHS_SEC22B.
ExpressionAtlasiO75396. baseline and differential.
GenevisibleiO75396. HS.

Family and domain databases

Gene3Di1.10.3840.10. 1 hit.
3.30.450.50. 1 hit.
InterProiIPR011012. Longin-like_dom.
IPR010908. Longin_dom.
IPR001388. Synaptobrevin.
[Graphical view]
PfamiPF13774. Longin. 1 hit.
PF00957. Synaptobrevin. 1 hit.
[Graphical view]
PRINTSiPR00219. SYNAPTOBREVN.
SMARTiSM01270. Longin. 1 hit.
[Graphical view]
SUPFAMiSSF64356. SSF64356. 1 hit.
PROSITEiPS50859. LONGIN. 1 hit.
PS50892. V_SNARE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSC22B_HUMAN
AccessioniPrimary (citable) accession number: O75396
Secondary accession number(s): A8K1G0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: January 11, 2011
Last modified: November 30, 2016
This is version 154 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The reference genome displays a polymorphic premature stop codon in position 39.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.