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O75394

- RM33_HUMAN

UniProt

O75394 - RM33_HUMAN

Protein

39S ribosomal protein L33, mitochondrial

Gene

MRPL33

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. structural constituent of ribosome Source: InterPro

    GO - Biological processi

    1. translation Source: InterPro

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    39S ribosomal protein L33, mitochondrial
    Short name:
    L33mt
    Short name:
    MRP-L33
    Gene namesi
    Name:MRPL33
    Synonyms:C2orf1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Organism-specific databases

    HGNCiHGNC:14487. MRPL33.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell
    2. ribosome Source: UniProtKB-KW

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30964.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 656539S ribosomal protein L33, mitochondrialPRO_0000238625Add
    BLAST

    Proteomic databases

    MaxQBiO75394.
    PaxDbiO75394.
    PRIDEiO75394.

    Expressioni

    Gene expression databases

    ArrayExpressiO75394.
    BgeeiO75394.
    CleanExiHS_MRPL33.
    GenevestigatoriO75394.

    Interactioni

    Protein-protein interaction databases

    BioGridi114925. 2 interactions.
    STRINGi9606.ENSP00000296102.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3IY9electron microscopy14.10P9-60[»]
    ProteinModelPortaliO75394.
    SMRiO75394. Positions 13-60.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L33P family.Curated

    Phylogenomic databases

    eggNOGiNOG48156.
    HOGENOMiHOG000004840.
    HOVERGENiHBG053140.
    KOiK02913.
    OMAiCIEEERE.
    OrthoDBiEOG7XSTMN.
    PhylomeDBiO75394.
    TreeFamiTF300279.

    Family and domain databases

    InterProiIPR001705. Ribosomal_L33.
    IPR011332. Ribosomal_zn-bd.
    [Graphical view]
    PfamiPF00471. Ribosomal_L33. 1 hit.
    [Graphical view]
    SUPFAMiSSF57829. SSF57829. 1 hit.
    TIGRFAMsiTIGR01023. rpmG_bact. 1 hit.
    ProtoNetiSearch...

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O75394-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MFLSAVFFAK SKSKNILVRM VSEAGTGFCF NTKRNRLREK LTLLHYDPVV   50
    KQRVLFVEKK KIRSL 65
    Length:65
    Mass (Da):7,619
    Last modified:November 1, 1998 - v1
    Checksum:iF32C16A238A5D08A
    GO
    Isoform 2 (identifier: O75394-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         14-65: KNILVRMVSE...FVEKKKIRSL → NETKSPLRGK...EGGDTDSEIL

    Note: No experimental confirmation available.

    Show »
    Length:54
    Mass (Da):5,965
    Checksum:i2BBEEFAA40BC171E
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei14 – 6552KNILV…KIRSL → NETKSPLRGKEKNTLPLNGG LKMTLIYKEKTEGGDTDSEI L in isoform 2. 1 PublicationVSP_042822Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF047440 mRNA. Translation: AAC39891.1.
    CR542117 mRNA. Translation: CAG46914.1.
    CR456888 mRNA. Translation: CAG33169.1.
    AC021171 Genomic DNA. No translation available.
    AC074091 Genomic DNA. Translation: AAX93204.1.
    AC110084 Genomic DNA. No translation available.
    CH471053 Genomic DNA. Translation: EAX00552.1.
    BC009475 mRNA. Translation: AAH09475.1.
    BC020834 mRNA. Translation: AAH20834.1.
    BC090047 mRNA. Translation: AAH90047.1.
    AB051623 Genomic DNA. Translation: BAB54951.1.
    CCDSiCCDS1761.1. [O75394-1]
    CCDS33167.1. [O75394-2]
    RefSeqiNP_004882.1. NM_004891.3. [O75394-1]
    NP_663303.1. NM_145330.2. [O75394-2]
    UniGeneiHs.515879.

    Genome annotation databases

    EnsembliENST00000296102; ENSP00000296102; ENSG00000243147. [O75394-1]
    ENST00000379666; ENSP00000368988; ENSG00000243147. [O75394-2]
    GeneIDi9553.
    KEGGihsa:9553.
    UCSCiuc002rlm.1. human. [O75394-1]
    uc002rln.1. human. [O75394-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF047440 mRNA. Translation: AAC39891.1 .
    CR542117 mRNA. Translation: CAG46914.1 .
    CR456888 mRNA. Translation: CAG33169.1 .
    AC021171 Genomic DNA. No translation available.
    AC074091 Genomic DNA. Translation: AAX93204.1 .
    AC110084 Genomic DNA. No translation available.
    CH471053 Genomic DNA. Translation: EAX00552.1 .
    BC009475 mRNA. Translation: AAH09475.1 .
    BC020834 mRNA. Translation: AAH20834.1 .
    BC090047 mRNA. Translation: AAH90047.1 .
    AB051623 Genomic DNA. Translation: BAB54951.1 .
    CCDSi CCDS1761.1. [O75394-1 ]
    CCDS33167.1. [O75394-2 ]
    RefSeqi NP_004882.1. NM_004891.3. [O75394-1 ]
    NP_663303.1. NM_145330.2. [O75394-2 ]
    UniGenei Hs.515879.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3IY9 electron microscopy 14.10 P 9-60 [» ]
    ProteinModelPortali O75394.
    SMRi O75394. Positions 13-60.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114925. 2 interactions.
    STRINGi 9606.ENSP00000296102.

    Proteomic databases

    MaxQBi O75394.
    PaxDbi O75394.
    PRIDEi O75394.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000296102 ; ENSP00000296102 ; ENSG00000243147 . [O75394-1 ]
    ENST00000379666 ; ENSP00000368988 ; ENSG00000243147 . [O75394-2 ]
    GeneIDi 9553.
    KEGGi hsa:9553.
    UCSCi uc002rlm.1. human. [O75394-1 ]
    uc002rln.1. human. [O75394-2 ]

    Organism-specific databases

    CTDi 9553.
    GeneCardsi GC02P027994.
    HGNCi HGNC:14487. MRPL33.
    MIMi 610059. gene.
    neXtProti NX_O75394.
    PharmGKBi PA30964.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG48156.
    HOGENOMi HOG000004840.
    HOVERGENi HBG053140.
    KOi K02913.
    OMAi CIEEERE.
    OrthoDBi EOG7XSTMN.
    PhylomeDBi O75394.
    TreeFami TF300279.

    Miscellaneous databases

    ChiTaRSi MRPL33. human.
    GeneWikii MRPL33.
    GenomeRNAii 9553.
    NextBioi 35825.
    PROi O75394.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O75394.
    Bgeei O75394.
    CleanExi HS_MRPL33.
    Genevestigatori O75394.

    Family and domain databases

    InterProi IPR001705. Ribosomal_L33.
    IPR011332. Ribosomal_zn-bd.
    [Graphical view ]
    Pfami PF00471. Ribosomal_L33. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57829. SSF57829. 1 hit.
    TIGRFAMsi TIGR01023. rpmG_bact. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning."
      Mao M., Fu G., Wu J.-S., Zhang Q.-H., Zhou J., Kan L.-X., Huang Q.-H., He K.-L., Gu B.-W., Han Z.-G., Shen Y., Gu J., Yu Y.-P., Xu S.-H., Wang Y.-X., Chen S.-J., Chen Z.
      Proc. Natl. Acad. Sci. U.S.A. 95:8175-8180(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Umbilical cord blood.
    2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain, Pituitary and Testis.
    7. "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders."
      Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S., Watanabe K., Tanaka T.
      Genomics 77:65-70(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 52-65.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRM33_HUMAN
    AccessioniPrimary (citable) accession number: O75394
    Secondary accession number(s): Q53RZ6, Q5FVE3, Q96Q50
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2006
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. Ribosomal proteins
      Ribosomal proteins families and list of entries
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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