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Protein

39S ribosomal protein L33, mitochondrial

Gene

MRPL33

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L33, mitochondrial
Short name:
L33mt
Short name:
MRP-L33
Alternative name(s):
Mitochondrial large ribosomal subunit protein bL33m1 Publication
Gene namesi
Name:MRPL33
Synonyms:C2orf1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000243147.7.
HGNCiHGNC:14487. MRPL33.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi9553.
OpenTargetsiENSG00000243147.
PharmGKBiPA30964.

Polymorphism and mutation databases

BioMutaiMRPL33.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 8MitochondrionBy similarity8
ChainiPRO_00002386259 – 6539S ribosomal protein L33, mitochondrialAdd BLAST57

Proteomic databases

EPDiO75394.
MaxQBiO75394.
PaxDbiO75394.
PeptideAtlasiO75394.
PRIDEiO75394.
TopDownProteomicsiO75394-1. [O75394-1]

PTM databases

PhosphoSitePlusiO75394.

Expressioni

Gene expression databases

BgeeiENSG00000243147.
CleanExiHS_MRPL33.
ExpressionAtlasiO75394. baseline and differential.
GenevisibleiO75394. HS.

Organism-specific databases

HPAiHPA066872.

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.2 Publications

Protein-protein interaction databases

BioGridi114925. 37 interactors.
CORUMiO75394.
IntActiO75394. 8 interactors.
STRINGi9606.ENSP00000296102.

Structurei

Secondary structure

165
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi15 – 25Combined sources11
Beta strandi29 – 35Combined sources7
Beta strandi42 – 47Combined sources6
Turni48 – 51Combined sources4
Beta strandi52 – 64Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3IY9electron microscopy14.10P9-60[»]
3J7Yelectron microscopy3.4011-65[»]
3J9Melectron microscopy3.5011-65[»]
5OOLelectron microscopy3.0611-65[»]
5OOMelectron microscopy3.0311-65[»]
ProteinModelPortaliO75394.
SMRiO75394.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3505. Eukaryota.
COG0267. LUCA.
GeneTreeiENSGT00390000010130.
HOGENOMiHOG000004840.
HOVERGENiHBG053140.
InParanoidiO75394.
KOiK02913.
OMAiAQTGFFY.
OrthoDBiEOG091G1BUE.
PhylomeDBiO75394.
TreeFamiTF300279.

Family and domain databases

InterProiView protein in InterPro
IPR001705. Ribosomal_L33.
IPR011332. Ribosomal_zn-bd.
PfamiView protein in Pfam
PF00471. Ribosomal_L33. 1 hit.
SUPFAMiSSF57829. SSF57829. 1 hit.
TIGRFAMsiTIGR01023. rpmG_bact. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75394-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFLSAVFFAK SKSKNILVRM VSEAGTGFCF NTKRNRLREK LTLLHYDPVV
60
KQRVLFVEKK KIRSL
Length:65
Mass (Da):7,619
Last modified:November 1, 1998 - v1
Checksum:iF32C16A238A5D08A
GO
Isoform 2 (identifier: O75394-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     14-65: KNILVRMVSE...FVEKKKIRSL → NETKSPLRGK...EGGDTDSEIL

Note: No experimental confirmation available.
Show »
Length:54
Mass (Da):5,965
Checksum:i2BBEEFAA40BC171E
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04282214 – 65KNILV…KIRSL → NETKSPLRGKEKNTLPLNGG LKMTLIYKEKTEGGDTDSEI L in isoform 2. 1 PublicationAdd BLAST52

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047440 mRNA. Translation: AAC39891.1.
CR542117 mRNA. Translation: CAG46914.1.
CR456888 mRNA. Translation: CAG33169.1.
AC021171 Genomic DNA. No translation available.
AC074091 Genomic DNA. Translation: AAX93204.1.
AC110084 Genomic DNA. No translation available.
CH471053 Genomic DNA. Translation: EAX00552.1.
BC009475 mRNA. Translation: AAH09475.1.
BC020834 mRNA. Translation: AAH20834.1.
BC090047 mRNA. Translation: AAH90047.1.
AB051623 Genomic DNA. Translation: BAB54951.1.
CCDSiCCDS1761.1. [O75394-1]
CCDS33167.1. [O75394-2]
RefSeqiNP_004882.1. NM_004891.3. [O75394-1]
NP_663303.1. NM_145330.2. [O75394-2]
UniGeneiHs.515879.

Genome annotation databases

EnsembliENST00000296102; ENSP00000296102; ENSG00000243147. [O75394-1]
ENST00000379666; ENSP00000368988; ENSG00000243147. [O75394-2]
GeneIDi9553.
KEGGihsa:9553.
UCSCiuc002rlm.1. human. [O75394-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRM33_HUMAN
AccessioniPrimary (citable) accession number: O75394
Secondary accession number(s): Q53RZ6, Q5FVE3, Q96Q50
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: November 1, 1998
Last modified: October 25, 2017
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families