Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

39S ribosomal protein L33, mitochondrial

Gene

MRPL33

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciZFISH:G66-31182-MONOMER.
ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L33, mitochondrial
Short name:
L33mt
Short name:
MRP-L33
Gene namesi
Name:MRPL33
Synonyms:C2orf1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:14487. MRPL33.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi9553.
OpenTargetsiENSG00000243147.
PharmGKBiPA30964.

Polymorphism and mutation databases

BioMutaiMRPL33.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 8MitochondrionBy similarity8
ChainiPRO_00002386259 – 6539S ribosomal protein L33, mitochondrialAdd BLAST57

Proteomic databases

EPDiO75394.
MaxQBiO75394.
PaxDbiO75394.
PeptideAtlasiO75394.
PRIDEiO75394.
TopDownProteomicsiO75394-1. [O75394-1]

PTM databases

PhosphoSitePlusiO75394.

Expressioni

Gene expression databases

BgeeiENSG00000243147.
CleanExiHS_MRPL33.
ExpressionAtlasiO75394. baseline and differential.
GenevisibleiO75394. HS.

Organism-specific databases

HPAiHPA066872.

Interactioni

Subunit structurei

Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.2 Publications

Protein-protein interaction databases

BioGridi114925. 16 interactors.
IntActiO75394. 8 interactors.
STRINGi9606.ENSP00000296102.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3IY9electron microscopy14.10P9-60[»]
3J7Yelectron microscopy3.4011-65[»]
3J9Melectron microscopy3.5011-65[»]
ProteinModelPortaliO75394.
SMRiO75394.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L33P family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3505. Eukaryota.
COG0267. LUCA.
GeneTreeiENSGT00390000010130.
HOGENOMiHOG000004840.
HOVERGENiHBG053140.
InParanoidiO75394.
KOiK02913.
OMAiAVKYDPR.
OrthoDBiEOG091G1BUE.
PhylomeDBiO75394.
TreeFamiTF300279.

Family and domain databases

InterProiIPR001705. Ribosomal_L33.
IPR011332. Ribosomal_zn-bd.
[Graphical view]
PfamiPF00471. Ribosomal_L33. 1 hit.
[Graphical view]
SUPFAMiSSF57829. SSF57829. 1 hit.
TIGRFAMsiTIGR01023. rpmG_bact. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75394-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFLSAVFFAK SKSKNILVRM VSEAGTGFCF NTKRNRLREK LTLLHYDPVV
60
KQRVLFVEKK KIRSL
Length:65
Mass (Da):7,619
Last modified:November 1, 1998 - v1
Checksum:iF32C16A238A5D08A
GO
Isoform 2 (identifier: O75394-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     14-65: KNILVRMVSE...FVEKKKIRSL → NETKSPLRGK...EGGDTDSEIL

Note: No experimental confirmation available.
Show »
Length:54
Mass (Da):5,965
Checksum:i2BBEEFAA40BC171E
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04282214 – 65KNILV…KIRSL → NETKSPLRGKEKNTLPLNGG LKMTLIYKEKTEGGDTDSEI L in isoform 2. 1 PublicationAdd BLAST52

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047440 mRNA. Translation: AAC39891.1.
CR542117 mRNA. Translation: CAG46914.1.
CR456888 mRNA. Translation: CAG33169.1.
AC021171 Genomic DNA. No translation available.
AC074091 Genomic DNA. Translation: AAX93204.1.
AC110084 Genomic DNA. No translation available.
CH471053 Genomic DNA. Translation: EAX00552.1.
BC009475 mRNA. Translation: AAH09475.1.
BC020834 mRNA. Translation: AAH20834.1.
BC090047 mRNA. Translation: AAH90047.1.
AB051623 Genomic DNA. Translation: BAB54951.1.
CCDSiCCDS1761.1. [O75394-1]
CCDS33167.1. [O75394-2]
RefSeqiNP_004882.1. NM_004891.3. [O75394-1]
NP_663303.1. NM_145330.2. [O75394-2]
UniGeneiHs.515879.

Genome annotation databases

EnsembliENST00000296102; ENSP00000296102; ENSG00000243147. [O75394-1]
ENST00000379666; ENSP00000368988; ENSG00000243147. [O75394-2]
GeneIDi9553.
KEGGihsa:9553.
UCSCiuc002rlm.1. human. [O75394-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047440 mRNA. Translation: AAC39891.1.
CR542117 mRNA. Translation: CAG46914.1.
CR456888 mRNA. Translation: CAG33169.1.
AC021171 Genomic DNA. No translation available.
AC074091 Genomic DNA. Translation: AAX93204.1.
AC110084 Genomic DNA. No translation available.
CH471053 Genomic DNA. Translation: EAX00552.1.
BC009475 mRNA. Translation: AAH09475.1.
BC020834 mRNA. Translation: AAH20834.1.
BC090047 mRNA. Translation: AAH90047.1.
AB051623 Genomic DNA. Translation: BAB54951.1.
CCDSiCCDS1761.1. [O75394-1]
CCDS33167.1. [O75394-2]
RefSeqiNP_004882.1. NM_004891.3. [O75394-1]
NP_663303.1. NM_145330.2. [O75394-2]
UniGeneiHs.515879.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3IY9electron microscopy14.10P9-60[»]
3J7Yelectron microscopy3.4011-65[»]
3J9Melectron microscopy3.5011-65[»]
ProteinModelPortaliO75394.
SMRiO75394.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114925. 16 interactors.
IntActiO75394. 8 interactors.
STRINGi9606.ENSP00000296102.

PTM databases

PhosphoSitePlusiO75394.

Polymorphism and mutation databases

BioMutaiMRPL33.

Proteomic databases

EPDiO75394.
MaxQBiO75394.
PaxDbiO75394.
PeptideAtlasiO75394.
PRIDEiO75394.
TopDownProteomicsiO75394-1. [O75394-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296102; ENSP00000296102; ENSG00000243147. [O75394-1]
ENST00000379666; ENSP00000368988; ENSG00000243147. [O75394-2]
GeneIDi9553.
KEGGihsa:9553.
UCSCiuc002rlm.1. human. [O75394-1]

Organism-specific databases

CTDi9553.
DisGeNETi9553.
GeneCardsiMRPL33.
HGNCiHGNC:14487. MRPL33.
HPAiHPA066872.
MIMi610059. gene.
neXtProtiNX_O75394.
OpenTargetsiENSG00000243147.
PharmGKBiPA30964.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3505. Eukaryota.
COG0267. LUCA.
GeneTreeiENSGT00390000010130.
HOGENOMiHOG000004840.
HOVERGENiHBG053140.
InParanoidiO75394.
KOiK02913.
OMAiAVKYDPR.
OrthoDBiEOG091G1BUE.
PhylomeDBiO75394.
TreeFamiTF300279.

Enzyme and pathway databases

BioCyciZFISH:G66-31182-MONOMER.
ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Miscellaneous databases

ChiTaRSiMRPL33. human.
GeneWikiiMRPL33.
GenomeRNAii9553.
PROiO75394.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000243147.
CleanExiHS_MRPL33.
ExpressionAtlasiO75394. baseline and differential.
GenevisibleiO75394. HS.

Family and domain databases

InterProiIPR001705. Ribosomal_L33.
IPR011332. Ribosomal_zn-bd.
[Graphical view]
PfamiPF00471. Ribosomal_L33. 1 hit.
[Graphical view]
SUPFAMiSSF57829. SSF57829. 1 hit.
TIGRFAMsiTIGR01023. rpmG_bact. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRM33_HUMAN
AccessioniPrimary (citable) accession number: O75394
Secondary accession number(s): Q53RZ6, Q5FVE3, Q96Q50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.