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O75394

- RM33_HUMAN

UniProt

O75394 - RM33_HUMAN

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Protein

39S ribosomal protein L33, mitochondrial

Gene
MRPL33, C2orf1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. structural constituent of ribosome Source: InterPro

GO - Biological processi

  1. translation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L33, mitochondrial
Short name:
L33mt
Short name:
MRP-L33
Gene namesi
Name:MRPL33
Synonyms:C2orf1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:14487. MRPL33.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-SubCell
  2. ribosome Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30964.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 656539S ribosomal protein L33, mitochondrialPRO_0000238625Add
BLAST

Proteomic databases

MaxQBiO75394.
PaxDbiO75394.
PRIDEiO75394.

Expressioni

Gene expression databases

ArrayExpressiO75394.
BgeeiO75394.
CleanExiHS_MRPL33.
GenevestigatoriO75394.

Interactioni

Protein-protein interaction databases

BioGridi114925. 1 interaction.
STRINGi9606.ENSP00000296102.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3IY9electron microscopy14.10P9-60[»]
ProteinModelPortaliO75394.
SMRiO75394. Positions 13-60.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG48156.
HOGENOMiHOG000004840.
HOVERGENiHBG053140.
KOiK02913.
OMAiCIEEERE.
OrthoDBiEOG7XSTMN.
PhylomeDBiO75394.
TreeFamiTF300279.

Family and domain databases

InterProiIPR001705. Ribosomal_L33.
IPR011332. Ribosomal_zn-bd.
[Graphical view]
PfamiPF00471. Ribosomal_L33. 1 hit.
[Graphical view]
SUPFAMiSSF57829. SSF57829. 1 hit.
TIGRFAMsiTIGR01023. rpmG_bact. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O75394-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MFLSAVFFAK SKSKNILVRM VSEAGTGFCF NTKRNRLREK LTLLHYDPVV   50
KQRVLFVEKK KIRSL 65
Length:65
Mass (Da):7,619
Last modified:November 1, 1998 - v1
Checksum:iF32C16A238A5D08A
GO
Isoform 2 (identifier: O75394-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     14-65: KNILVRMVSE...FVEKKKIRSL → NETKSPLRGK...EGGDTDSEIL

Note: No experimental confirmation available.

Show »
Length:54
Mass (Da):5,965
Checksum:i2BBEEFAA40BC171E
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei14 – 6552KNILV…KIRSL → NETKSPLRGKEKNTLPLNGG LKMTLIYKEKTEGGDTDSEI L in isoform 2. VSP_042822Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF047440 mRNA. Translation: AAC39891.1.
CR542117 mRNA. Translation: CAG46914.1.
CR456888 mRNA. Translation: CAG33169.1.
AC021171 Genomic DNA. No translation available.
AC074091 Genomic DNA. Translation: AAX93204.1.
AC110084 Genomic DNA. No translation available.
CH471053 Genomic DNA. Translation: EAX00552.1.
BC009475 mRNA. Translation: AAH09475.1.
BC020834 mRNA. Translation: AAH20834.1.
BC090047 mRNA. Translation: AAH90047.1.
AB051623 Genomic DNA. Translation: BAB54951.1.
CCDSiCCDS1761.1. [O75394-1]
CCDS33167.1. [O75394-2]
RefSeqiNP_004882.1. NM_004891.3. [O75394-1]
NP_663303.1. NM_145330.2. [O75394-2]
UniGeneiHs.515879.

Genome annotation databases

EnsembliENST00000296102; ENSP00000296102; ENSG00000243147. [O75394-1]
ENST00000379666; ENSP00000368988; ENSG00000243147. [O75394-2]
GeneIDi9553.
KEGGihsa:9553.
UCSCiuc002rlm.1. human. [O75394-1]
uc002rln.1. human. [O75394-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF047440 mRNA. Translation: AAC39891.1 .
CR542117 mRNA. Translation: CAG46914.1 .
CR456888 mRNA. Translation: CAG33169.1 .
AC021171 Genomic DNA. No translation available.
AC074091 Genomic DNA. Translation: AAX93204.1 .
AC110084 Genomic DNA. No translation available.
CH471053 Genomic DNA. Translation: EAX00552.1 .
BC009475 mRNA. Translation: AAH09475.1 .
BC020834 mRNA. Translation: AAH20834.1 .
BC090047 mRNA. Translation: AAH90047.1 .
AB051623 Genomic DNA. Translation: BAB54951.1 .
CCDSi CCDS1761.1. [O75394-1 ]
CCDS33167.1. [O75394-2 ]
RefSeqi NP_004882.1. NM_004891.3. [O75394-1 ]
NP_663303.1. NM_145330.2. [O75394-2 ]
UniGenei Hs.515879.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3IY9 electron microscopy 14.10 P 9-60 [» ]
ProteinModelPortali O75394.
SMRi O75394. Positions 13-60.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114925. 1 interaction.
STRINGi 9606.ENSP00000296102.

Proteomic databases

MaxQBi O75394.
PaxDbi O75394.
PRIDEi O75394.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000296102 ; ENSP00000296102 ; ENSG00000243147 . [O75394-1 ]
ENST00000379666 ; ENSP00000368988 ; ENSG00000243147 . [O75394-2 ]
GeneIDi 9553.
KEGGi hsa:9553.
UCSCi uc002rlm.1. human. [O75394-1 ]
uc002rln.1. human. [O75394-2 ]

Organism-specific databases

CTDi 9553.
GeneCardsi GC02P027994.
HGNCi HGNC:14487. MRPL33.
MIMi 610059. gene.
neXtProti NX_O75394.
PharmGKBi PA30964.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG48156.
HOGENOMi HOG000004840.
HOVERGENi HBG053140.
KOi K02913.
OMAi CIEEERE.
OrthoDBi EOG7XSTMN.
PhylomeDBi O75394.
TreeFami TF300279.

Miscellaneous databases

ChiTaRSi MRPL33. human.
GeneWikii MRPL33.
GenomeRNAii 9553.
NextBioi 35825.
PROi O75394.
SOURCEi Search...

Gene expression databases

ArrayExpressi O75394.
Bgeei O75394.
CleanExi HS_MRPL33.
Genevestigatori O75394.

Family and domain databases

InterProi IPR001705. Ribosomal_L33.
IPR011332. Ribosomal_zn-bd.
[Graphical view ]
Pfami PF00471. Ribosomal_L33. 1 hit.
[Graphical view ]
SUPFAMi SSF57829. SSF57829. 1 hit.
TIGRFAMsi TIGR01023. rpmG_bact. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning."
    Mao M., Fu G., Wu J.-S., Zhang Q.-H., Zhou J., Kan L.-X., Huang Q.-H., He K.-L., Gu B.-W., Han Z.-G., Shen Y., Gu J., Yu Y.-P., Xu S.-H., Wang Y.-X., Chen S.-J., Chen Z.
    Proc. Natl. Acad. Sci. U.S.A. 95:8175-8180(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Umbilical cord blood.
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain, Pituitary and Testis.
  7. "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders."
    Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S., Watanabe K., Tanaka T.
    Genomics 77:65-70(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 52-65.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRM33_HUMAN
AccessioniPrimary (citable) accession number: O75394
Secondary accession number(s): Q53RZ6, Q5FVE3, Q96Q50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: November 1, 1998
Last modified: July 9, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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