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Protein

Sperm-associated antigen 7

Gene

SPAG7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Sperm-associated antigen 7
Gene namesi
Name:SPAG7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:11216. SPAG7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36052.

Polymorphism and mutation databases

BioMutaiSPAG7.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 227226Sperm-associated antigen 7PRO_0000072097Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources
Modified residuei114 – 1141PhosphoserineCombined sources
Modified residuei158 – 1581PhosphoserineCombined sources
Modified residuei202 – 2021PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO75391.
MaxQBiO75391.
PaxDbiO75391.
PeptideAtlasiO75391.
PRIDEiO75391.

PTM databases

iPTMnetiO75391.
PhosphoSiteiO75391.

Expressioni

Tissue specificityi

Detected in fetal brain.1 Publication

Gene expression databases

BgeeiENSG00000091640.
CleanExiHS_SPAG7.
ExpressionAtlasiO75391. baseline and differential.
GenevisibleiO75391. HS.

Organism-specific databases

HPAiHPA024032.
HPA052394.

Interactioni

Protein-protein interaction databases

BioGridi114924. 6 interactions.
IntActiO75391. 1 interaction.
MINTiMINT-1033754.
STRINGi9606.ENSP00000206020.

Structurei

Secondary structure

1
227
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi45 – 6117Combined sources
Beta strandi67 – 693Combined sources
Helixi77 – 8812Combined sources
Beta strandi91 – 955Combined sources
Beta strandi97 – 1004Combined sources
Beta strandi103 – 1075Combined sources
Helixi115 – 1239Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CPMNMR-A44-124[»]
ProteinModelPortaliO75391.
SMRiO75391. Positions 44-124.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO75391.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 10964R3HPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi35 – 5117Nuclear localization signalSequence analysisAdd
BLAST
Motifi122 – 13918Nuclear localization signalSequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 R3H domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IG7F. Eukaryota.
ENOG4111H0W. LUCA.
GeneTreeiENSGT00390000001520.
HOGENOMiHOG000234363.
HOVERGENiHBG066267.
InParanoidiO75391.
OMAiHRSVIHE.
OrthoDBiEOG091G0QPO.
PhylomeDBiO75391.
TreeFamiTF323631.

Family and domain databases

Gene3Di3.30.1370.50. 1 hit.
InterProiIPR001374. R3H_dom.
IPR017330. SPAG7.
[Graphical view]
PfamiPF01424. R3H. 1 hit.
[Graphical view]
PIRSFiPIRSF037943. Sperm-assoc_antigen_PAG7. 1 hit.
SMARTiSM00393. R3H. 1 hit.
[Graphical view]
SUPFAMiSSF82708. SSF82708. 1 hit.
PROSITEiPS51061. R3H. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O75391-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADLLGSILS SMEKPPSLGD QETRRKAREQ AARLKKLQEQ EKQQKVEFRK
60 70 80 90 100
RMEKEVSDFI QDSGQIKKKF QPMNKIERSI LHDVVEVAGL TSFSFGEDDD
110 120 130 140 150
CRYVMIFKKE FAPSDEELDS YRRGEEWDPQ KAEEKRKLKE LAQRQEEEAA
160 170 180 190 200
QQGPVVVSPA SDYKDKYSHL IGKGAAKDAA HMLQANKTYG CVPVANKRDT
210 220
RSIEEAMNEI RAKKRLRQSG EELPPTS
Length:227
Mass (Da):26,034
Last modified:March 29, 2005 - v2
Checksum:i429566BE9B276EE4
GO

Sequence cautioni

The sequence AAC39888 differs from that shown. Reason: Frameshift at position 227. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047437 mRNA. Translation: AAC39888.1. Frameshift.
BC011934 mRNA. Translation: AAH11934.1.
CCDSiCCDS42240.1.
RefSeqiNP_004881.2. NM_004890.2.
UniGeneiHs.90436.

Genome annotation databases

EnsembliENST00000206020; ENSP00000206020; ENSG00000091640.
GeneIDi9552.
KEGGihsa:9552.
UCSCiuc002gae.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047437 mRNA. Translation: AAC39888.1. Frameshift.
BC011934 mRNA. Translation: AAH11934.1.
CCDSiCCDS42240.1.
RefSeqiNP_004881.2. NM_004890.2.
UniGeneiHs.90436.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CPMNMR-A44-124[»]
ProteinModelPortaliO75391.
SMRiO75391. Positions 44-124.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114924. 6 interactions.
IntActiO75391. 1 interaction.
MINTiMINT-1033754.
STRINGi9606.ENSP00000206020.

PTM databases

iPTMnetiO75391.
PhosphoSiteiO75391.

Polymorphism and mutation databases

BioMutaiSPAG7.

Proteomic databases

EPDiO75391.
MaxQBiO75391.
PaxDbiO75391.
PeptideAtlasiO75391.
PRIDEiO75391.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000206020; ENSP00000206020; ENSG00000091640.
GeneIDi9552.
KEGGihsa:9552.
UCSCiuc002gae.4. human.

Organism-specific databases

CTDi9552.
GeneCardsiSPAG7.
HGNCiHGNC:11216. SPAG7.
HPAiHPA024032.
HPA052394.
MIMi610056. gene.
neXtProtiNX_O75391.
PharmGKBiPA36052.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IG7F. Eukaryota.
ENOG4111H0W. LUCA.
GeneTreeiENSGT00390000001520.
HOGENOMiHOG000234363.
HOVERGENiHBG066267.
InParanoidiO75391.
OMAiHRSVIHE.
OrthoDBiEOG091G0QPO.
PhylomeDBiO75391.
TreeFamiTF323631.

Miscellaneous databases

ChiTaRSiSPAG7. human.
EvolutionaryTraceiO75391.
GeneWikiiSPAG7.
GenomeRNAii9552.
PROiO75391.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000091640.
CleanExiHS_SPAG7.
ExpressionAtlasiO75391. baseline and differential.
GenevisibleiO75391. HS.

Family and domain databases

Gene3Di3.30.1370.50. 1 hit.
InterProiIPR001374. R3H_dom.
IPR017330. SPAG7.
[Graphical view]
PfamiPF01424. R3H. 1 hit.
[Graphical view]
PIRSFiPIRSF037943. Sperm-assoc_antigen_PAG7. 1 hit.
SMARTiSM00393. R3H. 1 hit.
[Graphical view]
SUPFAMiSSF82708. SSF82708. 1 hit.
PROSITEiPS51061. R3H. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSPAG7_HUMAN
AccessioniPrimary (citable) accession number: O75391
Secondary accession number(s): Q96EU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: March 29, 2005
Last modified: September 7, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.