Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O75391

- SPAG7_HUMAN

UniProt

O75391 - SPAG7_HUMAN

Protein

Sperm-associated antigen 7

Gene

SPAG7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 2 (29 Mar 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Molecular functioni

    1. nucleic acid binding Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sperm-associated antigen 7
    Gene namesi
    Name:SPAG7
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:11216. SPAG7.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36052.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed3 Publications
    Chaini2 – 227226Sperm-associated antigen 7PRO_0000072097Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine3 Publications
    Modified residuei114 – 1141Phosphoserine1 Publication
    Modified residuei158 – 1581Phosphoserine2 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiO75391.
    PaxDbiO75391.
    PRIDEiO75391.

    PTM databases

    PhosphoSiteiO75391.

    Expressioni

    Tissue specificityi

    Detected in fetal brain.1 Publication

    Gene expression databases

    ArrayExpressiO75391.
    BgeeiO75391.
    CleanExiHS_SPAG7.
    GenevestigatoriO75391.

    Organism-specific databases

    HPAiHPA024032.
    HPA052394.

    Interactioni

    Protein-protein interaction databases

    BioGridi114924. 2 interactions.
    IntActiO75391. 1 interaction.
    MINTiMINT-1033754.
    STRINGi9606.ENSP00000206020.

    Structurei

    Secondary structure

    1
    227
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi45 – 6117
    Beta strandi67 – 693
    Helixi77 – 8812
    Beta strandi91 – 955
    Beta strandi97 – 1004
    Beta strandi103 – 1075
    Helixi115 – 1239

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2CPMNMR-A44-124[»]
    ProteinModelPortaliO75391.
    SMRiO75391. Positions 44-124.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO75391.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini46 – 10964R3HPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi35 – 5117Nuclear localization signalSequence AnalysisAdd
    BLAST
    Motifi122 – 13918Nuclear localization signalSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 R3H domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG75013.
    HOGENOMiHOG000234363.
    HOVERGENiHBG066267.
    InParanoidiO75391.
    OMAiEESRYVM.
    PhylomeDBiO75391.
    TreeFamiTF323631.

    Family and domain databases

    Gene3Di3.30.1370.50. 1 hit.
    InterProiIPR001374. R3H_ss-bd.
    IPR017330. Sperm-assoc_antigen_PAG7.
    [Graphical view]
    PfamiPF01424. R3H. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037943. Sperm-assoc_antigen_PAG7. 1 hit.
    SMARTiSM00393. R3H. 1 hit.
    [Graphical view]
    SUPFAMiSSF82708. SSF82708. 1 hit.
    PROSITEiPS51061. R3H. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O75391-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADLLGSILS SMEKPPSLGD QETRRKAREQ AARLKKLQEQ EKQQKVEFRK    50
    RMEKEVSDFI QDSGQIKKKF QPMNKIERSI LHDVVEVAGL TSFSFGEDDD 100
    CRYVMIFKKE FAPSDEELDS YRRGEEWDPQ KAEEKRKLKE LAQRQEEEAA 150
    QQGPVVVSPA SDYKDKYSHL IGKGAAKDAA HMLQANKTYG CVPVANKRDT 200
    RSIEEAMNEI RAKKRLRQSG EELPPTS 227
    Length:227
    Mass (Da):26,034
    Last modified:March 29, 2005 - v2
    Checksum:i429566BE9B276EE4
    GO

    Sequence cautioni

    The sequence AAC39888.1 differs from that shown. Reason: Frameshift at position 227.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF047437 mRNA. Translation: AAC39888.1. Frameshift.
    BC011934 mRNA. Translation: AAH11934.1.
    CCDSiCCDS42240.1.
    RefSeqiNP_004881.2. NM_004890.2.
    UniGeneiHs.90436.

    Genome annotation databases

    EnsembliENST00000206020; ENSP00000206020; ENSG00000091640.
    GeneIDi9552.
    KEGGihsa:9552.
    UCSCiuc002gae.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF047437 mRNA. Translation: AAC39888.1 . Frameshift.
    BC011934 mRNA. Translation: AAH11934.1 .
    CCDSi CCDS42240.1.
    RefSeqi NP_004881.2. NM_004890.2.
    UniGenei Hs.90436.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2CPM NMR - A 44-124 [» ]
    ProteinModelPortali O75391.
    SMRi O75391. Positions 44-124.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114924. 2 interactions.
    IntActi O75391. 1 interaction.
    MINTi MINT-1033754.
    STRINGi 9606.ENSP00000206020.

    PTM databases

    PhosphoSitei O75391.

    Proteomic databases

    MaxQBi O75391.
    PaxDbi O75391.
    PRIDEi O75391.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000206020 ; ENSP00000206020 ; ENSG00000091640 .
    GeneIDi 9552.
    KEGGi hsa:9552.
    UCSCi uc002gae.3. human.

    Organism-specific databases

    CTDi 9552.
    GeneCardsi GC17M004862.
    HGNCi HGNC:11216. SPAG7.
    HPAi HPA024032.
    HPA052394.
    MIMi 610056. gene.
    neXtProti NX_O75391.
    PharmGKBi PA36052.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG75013.
    HOGENOMi HOG000234363.
    HOVERGENi HBG066267.
    InParanoidi O75391.
    OMAi EESRYVM.
    PhylomeDBi O75391.
    TreeFami TF323631.

    Miscellaneous databases

    EvolutionaryTracei O75391.
    GeneWikii SPAG7.
    GenomeRNAii 9552.
    NextBioi 35821.
    PROi O75391.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O75391.
    Bgeei O75391.
    CleanExi HS_SPAG7.
    Genevestigatori O75391.

    Family and domain databases

    Gene3Di 3.30.1370.50. 1 hit.
    InterProi IPR001374. R3H_ss-bd.
    IPR017330. Sperm-assoc_antigen_PAG7.
    [Graphical view ]
    Pfami PF01424. R3H. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037943. Sperm-assoc_antigen_PAG7. 1 hit.
    SMARTi SM00393. R3H. 1 hit.
    [Graphical view ]
    SUPFAMi SSF82708. SSF82708. 1 hit.
    PROSITEi PS51061. R3H. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning."
      Mao M., Fu G., Wu J.-S., Zhang Q.-H., Zhou J., Kan L.-X., Huang Q.-H., He K.-L., Gu B.-W., Han Z.-G., Shen Y., Gu J., Yu Y.-P., Xu S.-H., Wang Y.-X., Chen S.-J., Chen Z.
      Proc. Natl. Acad. Sci. U.S.A. 95:8175-8180(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Umbilical cord blood.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Uterus.
    3. "Cloning and characterization of a fox sperm protein FSA-1."
      Beaton S., Cleary A., ten Have J., Bradley M.P.
      Reprod. Fertil. Dev. 6:761-770(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-114 AND SER-158, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-158, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Solution structure of the R3H domain of human sperm-associated antigen 7."
      RIKEN structural genomics initiative (RSGI)
      Submitted (NOV-2005) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 44-124.

    Entry informationi

    Entry nameiSPAG7_HUMAN
    AccessioniPrimary (citable) accession number: O75391
    Secondary accession number(s): Q96EU5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 29, 2005
    Last sequence update: March 29, 2005
    Last modified: October 1, 2014
    This is version 106 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3