Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Sperm-associated antigen 7

Gene

SPAG7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Sperm-associated antigen 7
Gene namesi
Name:SPAG7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000091640.7
HGNCiHGNC:11216 SPAG7
MIMi610056 gene
neXtProtiNX_O75391

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000091640
PharmGKBiPA36052

Polymorphism and mutation databases

BioMutaiSPAG7

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000720972 – 227Sperm-associated antigen 7Add BLAST226

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei114PhosphoserineCombined sources1
Modified residuei158PhosphoserineCombined sources1
Modified residuei202PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO75391
MaxQBiO75391
PaxDbiO75391
PeptideAtlasiO75391
PRIDEiO75391

PTM databases

iPTMnetiO75391
PhosphoSitePlusiO75391

Expressioni

Tissue specificityi

Detected in fetal brain.1 Publication

Gene expression databases

BgeeiENSG00000091640
CleanExiHS_SPAG7
ExpressionAtlasiO75391 baseline and differential
GenevisibleiO75391 HS

Organism-specific databases

HPAiHPA024032
HPA052394

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
LXNQ9BS404EBI-348464,EBI-1044504

Protein-protein interaction databases

BioGridi114924, 7 interactors
IntActiO75391, 4 interactors
STRINGi9606.ENSP00000206020

Structurei

Secondary structure

1227
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi45 – 61Combined sources17
Beta strandi67 – 69Combined sources3
Helixi77 – 88Combined sources12
Beta strandi91 – 95Combined sources5
Beta strandi97 – 100Combined sources4
Beta strandi103 – 107Combined sources5
Helixi115 – 123Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CPMNMR-A44-124[»]
ProteinModelPortaliO75391
SMRiO75391
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO75391

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 109R3HPROSITE-ProRule annotationAdd BLAST64

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi35 – 51Nuclear localization signalSequence analysisAdd BLAST17
Motifi122 – 139Nuclear localization signalSequence analysisAdd BLAST18

Phylogenomic databases

eggNOGiENOG410IG7F Eukaryota
ENOG4111H0W LUCA
GeneTreeiENSGT00390000001520
HOGENOMiHOG000234363
HOVERGENiHBG066267
InParanoidiO75391
OMAiHRSVIHE
OrthoDBiEOG091G0QPO
PhylomeDBiO75391
TreeFamiTF323631

Family and domain databases

CDDicd02636 R3H_sperm-antigen, 1 hit
Gene3Di3.30.1370.50, 1 hit
InterProiView protein in InterPro
IPR001374 R3H_dom
IPR036867 R3H_dom_sf
IPR034068 R3H_sperm-antigen
IPR017330 SPAG7
PANTHERiPTHR13498 PTHR13498, 1 hit
PfamiView protein in Pfam
PF01424 R3H, 1 hit
PIRSFiPIRSF037943 Sperm-assoc_antigen_PAG7, 1 hit
SMARTiView protein in SMART
SM00393 R3H, 1 hit
SUPFAMiSSF82708 SSF82708, 1 hit
PROSITEiView protein in PROSITE
PS51061 R3H, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O75391-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADLLGSILS SMEKPPSLGD QETRRKAREQ AARLKKLQEQ EKQQKVEFRK
60 70 80 90 100
RMEKEVSDFI QDSGQIKKKF QPMNKIERSI LHDVVEVAGL TSFSFGEDDD
110 120 130 140 150
CRYVMIFKKE FAPSDEELDS YRRGEEWDPQ KAEEKRKLKE LAQRQEEEAA
160 170 180 190 200
QQGPVVVSPA SDYKDKYSHL IGKGAAKDAA HMLQANKTYG CVPVANKRDT
210 220
RSIEEAMNEI RAKKRLRQSG EELPPTS
Length:227
Mass (Da):26,034
Last modified:March 29, 2005 - v2
Checksum:i429566BE9B276EE4
GO

Sequence cautioni

The sequence AAC39888 differs from that shown. Reason: Frameshift at position 227.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047437 mRNA Translation: AAC39888.1 Frameshift.
BC011934 mRNA Translation: AAH11934.1
CCDSiCCDS42240.1
RefSeqiNP_004881.2, NM_004890.2
UniGeneiHs.90436

Genome annotation databases

EnsembliENST00000206020; ENSP00000206020; ENSG00000091640
GeneIDi9552
KEGGihsa:9552
UCSCiuc002gae.4 human

Similar proteinsi

Entry informationi

Entry nameiSPAG7_HUMAN
AccessioniPrimary (citable) accession number: O75391
Secondary accession number(s): Q96EU5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: March 29, 2005
Last modified: May 23, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health