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Protein

Sperm-associated antigen 7

Gene

SPAG7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000091640-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Sperm-associated antigen 7
Gene namesi
Name:SPAG7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:11216. SPAG7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi9552.
OpenTargetsiENSG00000091640.
PharmGKBiPA36052.

Polymorphism and mutation databases

BioMutaiSPAG7.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000720972 – 227Sperm-associated antigen 7Add BLAST226

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei114PhosphoserineCombined sources1
Modified residuei158PhosphoserineCombined sources1
Modified residuei202PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO75391.
MaxQBiO75391.
PaxDbiO75391.
PeptideAtlasiO75391.
PRIDEiO75391.

PTM databases

iPTMnetiO75391.
PhosphoSitePlusiO75391.

Expressioni

Tissue specificityi

Detected in fetal brain.1 Publication

Gene expression databases

BgeeiENSG00000091640.
CleanExiHS_SPAG7.
ExpressionAtlasiO75391. baseline and differential.
GenevisibleiO75391. HS.

Organism-specific databases

HPAiHPA024032.
HPA052394.

Interactioni

Protein-protein interaction databases

BioGridi114924. 6 interactors.
IntActiO75391. 2 interactors.
MINTiMINT-1033754.
STRINGi9606.ENSP00000206020.

Structurei

Secondary structure

1227
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi45 – 61Combined sources17
Beta strandi67 – 69Combined sources3
Helixi77 – 88Combined sources12
Beta strandi91 – 95Combined sources5
Beta strandi97 – 100Combined sources4
Beta strandi103 – 107Combined sources5
Helixi115 – 123Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CPMNMR-A44-124[»]
ProteinModelPortaliO75391.
SMRiO75391.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO75391.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 109R3HPROSITE-ProRule annotationAdd BLAST64

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi35 – 51Nuclear localization signalSequence analysisAdd BLAST17
Motifi122 – 139Nuclear localization signalSequence analysisAdd BLAST18

Sequence similaritiesi

Contains 1 R3H domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IG7F. Eukaryota.
ENOG4111H0W. LUCA.
GeneTreeiENSGT00390000001520.
HOGENOMiHOG000234363.
HOVERGENiHBG066267.
InParanoidiO75391.
OMAiHRSVIHE.
OrthoDBiEOG091G0QPO.
PhylomeDBiO75391.
TreeFamiTF323631.

Family and domain databases

Gene3Di3.30.1370.50. 1 hit.
InterProiIPR001374. R3H_dom.
IPR017330. SPAG7.
[Graphical view]
PfamiPF01424. R3H. 1 hit.
[Graphical view]
PIRSFiPIRSF037943. Sperm-assoc_antigen_PAG7. 1 hit.
SMARTiSM00393. R3H. 1 hit.
[Graphical view]
SUPFAMiSSF82708. SSF82708. 1 hit.
PROSITEiPS51061. R3H. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O75391-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADLLGSILS SMEKPPSLGD QETRRKAREQ AARLKKLQEQ EKQQKVEFRK
60 70 80 90 100
RMEKEVSDFI QDSGQIKKKF QPMNKIERSI LHDVVEVAGL TSFSFGEDDD
110 120 130 140 150
CRYVMIFKKE FAPSDEELDS YRRGEEWDPQ KAEEKRKLKE LAQRQEEEAA
160 170 180 190 200
QQGPVVVSPA SDYKDKYSHL IGKGAAKDAA HMLQANKTYG CVPVANKRDT
210 220
RSIEEAMNEI RAKKRLRQSG EELPPTS
Length:227
Mass (Da):26,034
Last modified:March 29, 2005 - v2
Checksum:i429566BE9B276EE4
GO

Sequence cautioni

The sequence AAC39888 differs from that shown. Reason: Frameshift at position 227.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047437 mRNA. Translation: AAC39888.1. Frameshift.
BC011934 mRNA. Translation: AAH11934.1.
CCDSiCCDS42240.1.
RefSeqiNP_004881.2. NM_004890.2.
UniGeneiHs.90436.

Genome annotation databases

EnsembliENST00000206020; ENSP00000206020; ENSG00000091640.
GeneIDi9552.
KEGGihsa:9552.
UCSCiuc002gae.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047437 mRNA. Translation: AAC39888.1. Frameshift.
BC011934 mRNA. Translation: AAH11934.1.
CCDSiCCDS42240.1.
RefSeqiNP_004881.2. NM_004890.2.
UniGeneiHs.90436.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CPMNMR-A44-124[»]
ProteinModelPortaliO75391.
SMRiO75391.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114924. 6 interactors.
IntActiO75391. 2 interactors.
MINTiMINT-1033754.
STRINGi9606.ENSP00000206020.

PTM databases

iPTMnetiO75391.
PhosphoSitePlusiO75391.

Polymorphism and mutation databases

BioMutaiSPAG7.

Proteomic databases

EPDiO75391.
MaxQBiO75391.
PaxDbiO75391.
PeptideAtlasiO75391.
PRIDEiO75391.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000206020; ENSP00000206020; ENSG00000091640.
GeneIDi9552.
KEGGihsa:9552.
UCSCiuc002gae.4. human.

Organism-specific databases

CTDi9552.
DisGeNETi9552.
GeneCardsiSPAG7.
HGNCiHGNC:11216. SPAG7.
HPAiHPA024032.
HPA052394.
MIMi610056. gene.
neXtProtiNX_O75391.
OpenTargetsiENSG00000091640.
PharmGKBiPA36052.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IG7F. Eukaryota.
ENOG4111H0W. LUCA.
GeneTreeiENSGT00390000001520.
HOGENOMiHOG000234363.
HOVERGENiHBG066267.
InParanoidiO75391.
OMAiHRSVIHE.
OrthoDBiEOG091G0QPO.
PhylomeDBiO75391.
TreeFamiTF323631.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000091640-MONOMER.

Miscellaneous databases

ChiTaRSiSPAG7. human.
EvolutionaryTraceiO75391.
GeneWikiiSPAG7.
GenomeRNAii9552.
PROiO75391.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000091640.
CleanExiHS_SPAG7.
ExpressionAtlasiO75391. baseline and differential.
GenevisibleiO75391. HS.

Family and domain databases

Gene3Di3.30.1370.50. 1 hit.
InterProiIPR001374. R3H_dom.
IPR017330. SPAG7.
[Graphical view]
PfamiPF01424. R3H. 1 hit.
[Graphical view]
PIRSFiPIRSF037943. Sperm-assoc_antigen_PAG7. 1 hit.
SMARTiSM00393. R3H. 1 hit.
[Graphical view]
SUPFAMiSSF82708. SSF82708. 1 hit.
PROSITEiPS51061. R3H. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSPAG7_HUMAN
AccessioniPrimary (citable) accession number: O75391
Secondary accession number(s): Q96EU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: March 29, 2005
Last modified: November 30, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.