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Protein

Probable G-protein coupled receptor 32

Gene

GPR32

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

  • G-protein coupled receptor activity Source: ProtInc

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 32
Gene namesi
Name:GPR32
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:4487. GPR32.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4444ExtracellularSequence analysisAdd
BLAST
Transmembranei45 – 6723Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini68 – 7811CytoplasmicSequence analysisAdd
BLAST
Transmembranei79 – 10022Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini101 – 11616ExtracellularSequence analysisAdd
BLAST
Transmembranei117 – 13721Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini138 – 15619CytoplasmicSequence analysisAdd
BLAST
Transmembranei157 – 17822Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini179 – 22042ExtracellularSequence analysisAdd
BLAST
Transmembranei221 – 24121Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini242 – 25716CytoplasmicSequence analysisAdd
BLAST
Transmembranei258 – 28023Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini281 – 30020ExtracellularSequence analysisAdd
BLAST
Transmembranei301 – 32020Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini321 – 35636CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28875.

Chemistry

GuidetoPHARMACOLOGYi99.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 356356Probable G-protein coupled receptor 32PRO_0000069552Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi30 – 301N-linked (GlcNAc...)Sequence analysis
Disulfide bondi114 ↔ 191PROSITE-ProRule annotation
Glycosylationi199 – 1991N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO75388.
PRIDEiO75388.

PTM databases

iPTMnetiO75388.
PhosphoSiteiO75388.

Expressioni

Gene expression databases

BgeeiENSG00000142511.
CleanExiHS_GPR32.
ExpressionAtlasiO75388. baseline and differential.
GenevisibleiO75388. HS.

Organism-specific databases

HPAiHPA030330.

Structurei

3D structure databases

ProteinModelPortaliO75388.
SMRiO75388. Positions 49-329.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J9ZX. Eukaryota.
ENOG4111EAW. LUCA.
GeneTreeiENSGT00760000118990.
HOGENOMiHOG000234122.
HOVERGENiHBG107962.
InParanoidiO75388.
KOiK08381.
OMAiQWLLGEW.
OrthoDBiEOG091G0L0L.
PhylomeDBiO75388.
TreeFamiTF341723.

Family and domain databases

InterProiIPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24225. PTHR24225. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O75388-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGVSEGTRG CSDRQPGVLT RDRSCSRKMN SSGCLSEEVG SLRPLTVVIL
60 70 80 90 100
SASIVVGVLG NGLVLWMTVF RMARTVSTVC FFHLALADFM LSLSLPIAMY
110 120 130 140 150
YIVSRQWLLG EWACKLYITF VFLSYFASNC LLVFISVDRC ISVLYPVWAL
160 170 180 190 200
NHRTVQRASW LAFGVWLLAA ALCSAHLKFR TTRKWNGCTH CYLAFNSDNE
210 220 230 240 250
TAQIWIEGVV EGHIIGTIGH FLLGFLGPLA IIGTCAHLIR AKLLREGWVH
260 270 280 290 300
ANRPKRLLLV LVSAFFIFWS PFNVVLLVHL WRRVMLKEIY HPRMLLILQA
310 320 330 340 350
SFALGCVNSS LNPFLYVFVG RDFQEKFFQS LTSALARAFG EEEFLSSCPR

GNAPRE
Length:356
Mass (Da):40,087
Last modified:November 1, 1998 - v1
Checksum:i0E00DCF4BD7F4C3A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti167 – 1671L → P in AAH67453 (PubMed:15489334).Curated
Sequence conflicti186 – 1861N → D in AAH67453 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti327 – 3271F → L.
Corresponds to variant rs1864011 [ dbSNP | Ensembl ].
VAR_011860

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF045764 Genomic DNA. Translation: AAC39801.1.
BC067453 mRNA. Translation: AAH67453.1.
BC067454 mRNA. Translation: AAH67454.1.
BC095544 mRNA. Translation: AAH95544.1.
CCDSiCCDS12801.1.
RefSeqiNP_001497.1. NM_001506.2.
UniGeneiHs.515555.

Genome annotation databases

EnsembliENST00000270590; ENSP00000270590; ENSG00000142511.
GeneIDi2854.
KEGGihsa:2854.
UCSCiuc010ycf.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF045764 Genomic DNA. Translation: AAC39801.1.
BC067453 mRNA. Translation: AAH67453.1.
BC067454 mRNA. Translation: AAH67454.1.
BC095544 mRNA. Translation: AAH95544.1.
CCDSiCCDS12801.1.
RefSeqiNP_001497.1. NM_001506.2.
UniGeneiHs.515555.

3D structure databases

ProteinModelPortaliO75388.
SMRiO75388. Positions 49-329.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

GuidetoPHARMACOLOGYi99.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiO75388.
PhosphoSiteiO75388.

Proteomic databases

PaxDbiO75388.
PRIDEiO75388.

Protocols and materials databases

DNASUi2854.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000270590; ENSP00000270590; ENSG00000142511.
GeneIDi2854.
KEGGihsa:2854.
UCSCiuc010ycf.3. human.

Organism-specific databases

CTDi2854.
GeneCardsiGPR32.
HGNCiHGNC:4487. GPR32.
HPAiHPA030330.
MIMi603195. gene.
neXtProtiNX_O75388.
PharmGKBiPA28875.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J9ZX. Eukaryota.
ENOG4111EAW. LUCA.
GeneTreeiENSGT00760000118990.
HOGENOMiHOG000234122.
HOVERGENiHBG107962.
InParanoidiO75388.
KOiK08381.
OMAiQWLLGEW.
OrthoDBiEOG091G0L0L.
PhylomeDBiO75388.
TreeFamiTF341723.

Enzyme and pathway databases

ReactomeiR-HSA-418555. G alpha (s) signalling events.

Miscellaneous databases

GeneWikiiGPR32.
GenomeRNAii2854.
PROiO75388.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000142511.
CleanExiHS_GPR32.
ExpressionAtlasiO75388. baseline and differential.
GenevisibleiO75388. HS.

Family and domain databases

InterProiIPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24225. PTHR24225. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPR32_HUMAN
AccessioniPrimary (citable) accession number: O75388
Secondary accession number(s): Q502U7, Q6NWS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: September 7, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.