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Protein

Large neutral amino acids transporter small subunit 3

Gene

SLC43A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sodium-independent, high affinity transport of large neutral amino acids. Has narrower substrate selectivity compared to SLC7A5 and SLC7A8 and mainly transports branched-chain amino acids and phenylalanine. Plays a role in the development of human prostate cancer, from prostatic intraepithelial neoplasia to invasive prostate cancer.4 Publications

GO - Molecular functioni

  1. L-amino acid transmembrane transporter activity Source: Ensembl
  2. neutral amino acid transmembrane transporter activity Source: UniProtKB

GO - Biological processi

  1. amino acid transport Source: Reactome
  2. ion transport Source: Reactome
  3. neutral amino acid transport Source: UniProtKB
  4. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

ReactomeiREACT_13796. Amino acid transport across the plasma membrane.

Protein family/group databases

TCDBi2.A.1.44.1. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Large neutral amino acids transporter small subunit 3
Alternative name(s):
L-type amino acid transporter 3
Prostate cancer overexpressed gene 1 protein
Solute carrier family 43 member 1
Gene namesi
Name:SLC43A1Imported
Synonyms:LAT3Imported, PB391 Publication, POV11 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:9225. SLC43A1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei20 – 4021HelicalSequence AnalysisAdd
BLAST
Transmembranei78 – 9821HelicalSequence AnalysisAdd
BLAST
Transmembranei105 – 12420HelicalSequence AnalysisAdd
BLAST
Transmembranei131 – 15121HelicalSequence AnalysisAdd
BLAST
Transmembranei168 – 18821HelicalSequence AnalysisAdd
BLAST
Transmembranei191 – 21121HelicalSequence AnalysisAdd
BLAST
Transmembranei304 – 32421HelicalSequence AnalysisAdd
BLAST
Transmembranei357 – 37721HelicalSequence AnalysisAdd
BLAST
Transmembranei419 – 43921HelicalSequence AnalysisAdd
BLAST
Transmembranei446 – 46621HelicalSequence AnalysisAdd
BLAST
Transmembranei485 – 50521HelicalSequence AnalysisAdd
BLAST
Transmembranei510 – 53021HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: UniProtKB
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33549.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 559559Large neutral amino acids transporter small subunit 3PRO_0000218640Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi57 – 571N-linked (GlcNAc...)Sequence Analysis
Glycosylationi212 – 2121N-linked (GlcNAc...)Sequence Analysis
Glycosylationi229 – 2291N-linked (GlcNAc...)Sequence Analysis
Modified residuei267 – 2671Phosphoserine1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiO75387.
PaxDbiO75387.
PRIDEiO75387.

PTM databases

PhosphoSiteiO75387.

Expressioni

Tissue specificityi

In adults, found in all tissues examined with highest expression in pancreas. In fetus, highest expression in liver and lower levels in kidney, and lung. High levels found in prostate cancer cells.4 Publications

Gene expression databases

BgeeiO75387.
CleanExiHS_SLC43A1.
ExpressionAtlasiO75387. baseline and differential.
GenevestigatoriO75387.

Organism-specific databases

HPAiHPA018813.
HPA018826.

Interactioni

Protein-protein interaction databases

BioGridi114073. 2 interactions.
DIPiDIP-47272N.
IntActiO75387. 1 interaction.
STRINGi9606.ENSP00000278426.

Structurei

3D structure databases

ProteinModelPortaliO75387.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG71084.
GeneTreeiENSGT00530000063043.
HOGENOMiHOG000231937.
HOVERGENiHBG072879.
InParanoidiO75387.
KOiK08228.
OMAiNWPVEAF.
OrthoDBiEOG712TWX.
PhylomeDBiO75387.
TreeFamiTF328358.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: O75387-1) [UniParc]FASTAAdd to basket

Also known as: 2.3kb1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPTLQQAYR RRWWMACTAV LENLFFSAVL LGWGSLLIIL KNEGFYSSTC
60 70 80 90 100
PAESSTNTTQ DEQRRWPGCD QQDEMLNLGF TIGSFVLSAT TLPLGILMDR
110 120 130 140 150
FGPRPVRLVG SACFTASCTL MALASRDVEA LSPLIFLALS LNGFGGICLT
160 170 180 190 200
FTSLTLPNMF GNLRSTLMAL MIGSYASSAI TFPGIKLIYD AGVAFVVIMF
210 220 230 240 250
TWSGLACLIF LNCTLNWPIE AFPAPEEVNY TKKIKLSGLA LDHKVTGDLF
260 270 280 290 300
YTHVTTMGQR LSQKAPSLED GSDAFMSPQD VRGTSENLPE RSVPLRKSLC
310 320 330 340 350
SPTFLWSLLT MGMTQLRIIF YMAAVNKMLE YLVTGGQEHE TNEQQQKVAE
360 370 380 390 400
TVGFYSSVFG AMQLLCLLTC PLIGYIMDWR IKDCVDAPTQ GTVLGDARDG
410 420 430 440 450
VATKSIRPRY CKIQKLTNAI SAFTLTNLLL VGFGITCLIN NLHLQFVTFV
460 470 480 490 500
LHTIVRGFFH SACGSLYAAV FPSNHFGTLT GLQSLISAVF ALLQQPLFMA
510 520 530 540 550
MVGPLKGEPF WVNLGLLLFS LLGFLLPSYL FYYRARLQQE YAANGMGPLK

VLSGSEVTA
Length:559
Mass (Da):61,477
Last modified:November 1, 1998 - v1
Checksum:i49B0DECA3D930A45
GO
Isoform 21 Publication (identifier: O75387-2) [UniParc]FASTAAdd to basket

Also known as: 5kb1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     513-559: NLGLLLFSLL...KVLSGSEVTA → RARVGVGGAG...NLQVSKLSAF

Show »
Length:560
Mass (Da):61,051
Checksum:iCC4C698554DF06D1
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti238 – 2381G → V.
Corresponds to variant rs17151933 [ dbSNP | Ensembl ].
VAR_053670
Natural varianti443 – 4431H → Y.
Corresponds to variant rs34746107 [ dbSNP | Ensembl ].
VAR_053671

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei513 – 55947NLGLL…SEVTA → RARVGVGGAGATLLGAGVGP CMWCHPSLISARGTSEVSNL QVSKLSAF in isoform 2. 1 PublicationVSP_051620Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF045584 mRNA. Translation: AAC33004.1.
AB103033 mRNA. Translation: BAD00152.1.
BC001639 mRNA. Translation: AAH01639.1.
CCDSiCCDS7958.1. [O75387-1]
RefSeqiNP_001185739.1. NM_001198810.1. [O75387-1]
NP_003618.1. NM_003627.5. [O75387-1]
UniGeneiHs.591952.
Hs.735724.

Genome annotation databases

EnsembliENST00000278426; ENSP00000278426; ENSG00000149150. [O75387-1]
ENST00000528450; ENSP00000435673; ENSG00000149150. [O75387-1]
GeneIDi8501.
KEGGihsa:8501.
UCSCiuc001nkk.3. human. [O75387-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF045584 mRNA. Translation: AAC33004.1.
AB103033 mRNA. Translation: BAD00152.1.
BC001639 mRNA. Translation: AAH01639.1.
CCDSiCCDS7958.1. [O75387-1]
RefSeqiNP_001185739.1. NM_001198810.1. [O75387-1]
NP_003618.1. NM_003627.5. [O75387-1]
UniGeneiHs.591952.
Hs.735724.

3D structure databases

ProteinModelPortaliO75387.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114073. 2 interactions.
DIPiDIP-47272N.
IntActiO75387. 1 interaction.
STRINGi9606.ENSP00000278426.

Protein family/group databases

TCDBi2.A.1.44.1. the major facilitator superfamily (mfs).

PTM databases

PhosphoSiteiO75387.

Proteomic databases

MaxQBiO75387.
PaxDbiO75387.
PRIDEiO75387.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000278426; ENSP00000278426; ENSG00000149150. [O75387-1]
ENST00000528450; ENSP00000435673; ENSG00000149150. [O75387-1]
GeneIDi8501.
KEGGihsa:8501.
UCSCiuc001nkk.3. human. [O75387-1]

Organism-specific databases

CTDi8501.
GeneCardsiGC11M057252.
HGNCiHGNC:9225. SLC43A1.
HPAiHPA018813.
HPA018826.
MIMi603733. gene.
neXtProtiNX_O75387.
PharmGKBiPA33549.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG71084.
GeneTreeiENSGT00530000063043.
HOGENOMiHOG000231937.
HOVERGENiHBG072879.
InParanoidiO75387.
KOiK08228.
OMAiNWPVEAF.
OrthoDBiEOG712TWX.
PhylomeDBiO75387.
TreeFamiTF328358.

Enzyme and pathway databases

ReactomeiREACT_13796. Amino acid transport across the plasma membrane.

Miscellaneous databases

ChiTaRSiSLC43A1. human.
GeneWikiiSLC43A1.
GenomeRNAii8501.
NextBioi31811.
PROiO75387.
SOURCEiSearch...

Gene expression databases

BgeeiO75387.
CleanExiHS_SLC43A1.
ExpressionAtlasiO75387. baseline and differential.
GenevestigatoriO75387.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA sequencing and analysis of POV1 (PB39): a novel gene up-regulated in prostate cancer."
    Cole K.A., Chuaqui R.F., Katz K., Pack S., Zhuang Z., Cole C.E., Lyne J.C., Linehan W.M., Liotta L.A., Emmert-Buck M.R.
    Genomics 51:282-287(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, TISSUE SPECIFICITY.
  2. "Identification of a novel system L amino acid transporter structurally distinct from heterodimeric amino acid transporters."
    Babu E., Kanai Y., Chairoungdua A., Kim D.K., Iribe Y., Tangtrongsup S., Jutabha P., Li Y., Ahmed N., Sakamoto S., Anzai N., Nagamori S., Endou H.
    J. Biol. Chem. 278:43838-43845(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
    Tissue: LiverImported.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: ColonImported.
  4. "Identification of a novel transcript up-regulated in a clinically aggressive prostate carcinoma."
    Chuaqui R.F., Englert C.R., Strup S.E., Vocke C.D., Zhuang Z., Duray P.H., Bostwick D.G., Linehan W.M., Liotta L.A., Emmert-Buck M.R.
    Urology 50:302-307(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL NUCLEOTIDE SEQUENCE (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
  5. "New insights into testicular germ cell tumorigenesis from gene expression profiling."
    Skotheim R.I., Monni O., Mousses S., Fossaa S.D., Kallioniemi O.-P., Lothe R.A., Kallioniemi A.
    Cancer Res. 62:2359-2364(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-267, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiLAT3_HUMAN
AccessioniPrimary (citable) accession number: O75387
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: November 1, 1998
Last modified: March 4, 2015
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Up-regulated in early prostate cancer development with highest expression level in seminomas of testicular germ cell tumors.2 Publications

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.