O75387 (LAT3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Large neutral amino acids transporter small subunit 3

Alternative name(s):
L-type amino acid transporter 3
Prostate cancer overexpressed gene 1 protein
Solute carrier family 43 member 1

Gene names

Name:	SLC43A1
Synonyms:	LAT3, PB39, POV1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	559 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Sodium-independent, high affinity transport of large neutral amino acids. Has narrower substrate selectivity compared to SLC7A5 and SLC7A8 and mainly transports branched-chain amino acids and phenylalanine. Plays a role in the development of human prostate cancer, from prostatic intraepithelial neoplasia to invasive prostate cancer. Ref.1 Ref.2 Ref.4 Ref.5
Subcellular location	Membrane; Multi-pass membrane protein Probable.
Tissue specificity	In adults, found in all tissues examined with highest expression in pancreas. In fetus, highest expression in liver and lower levels in kidney, and lung. High levels found in prostate cancer cells. Ref.1 Ref.2 Ref.4 Ref.5
Miscellaneous	Up-regulated in early prostate cancer development with highest expression level in seminomas of testicular germ cell tumors. Ref.4 Ref.5
Sequence similarities	Belongs to the SLC43A transporter (TC 2.A.1.44) family. [View classification]

Ontologies

Keywords
Biological process	Amino-acid transport Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cellular nitrogen compound metabolic process Traceable author statement. Source: Reactome ion transport Traceable author statement. Source: Reactome
Cellular component	integral to plasma membrane Traceable author statement Ref.2. Source: UniProtKB
Molecular function	neutral amino acid transmembrane transporter activity Inferred from direct assay Ref.2. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 Ref.1 (identifier: O75387-1)

Also known as: 2.3kb;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 Ref.1 (identifier: O75387-2)

Also known as: 5kb;

The sequence of this isoform differs from the canonical sequence as follows:
     513-559: NLGLLLFSLL...KVLSGSEVTA → RARVGVGGAG...NLQVSKLSAF

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 559	559	Large neutral amino acids transporter small subunit 3		PRO_0000218640
Regions
	Transmembrane	20 – 40	21	Helical; Potential
	Transmembrane	78 – 98	21	Helical; Potential
	Transmembrane	105 – 124	20	Helical; Potential
	Transmembrane	131 – 151	21	Helical; Potential
	Transmembrane	168 – 188	21	Helical; Potential
	Transmembrane	191 – 211	21	Helical; Potential
	Transmembrane	304 – 324	21	Helical; Potential
	Transmembrane	357 – 377	21	Helical; Potential
	Transmembrane	419 – 439	21	Helical; Potential
	Transmembrane	446 – 466	21	Helical; Potential
	Transmembrane	485 – 505	21	Helical; Potential
	Transmembrane	510 – 530	21	Helical; Potential
Amino acid modifications
	Glycosylation	57	1	N-linked (GlcNAc...) Potential
	Glycosylation	212	1	N-linked (GlcNAc...) Potential
	Glycosylation	229	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	513 – 559	47	NLGLL…SEVTA → RARVGVGGAGATLLGAGVGP CMWCHPSLISARGTSEVSNL QVSKLSAF in isoform 2. Ref.1		VSP_051620
	Natural variant	238	1	G → V. Corresponds to variant rs17151933 [ dbSNP | Ensembl ].		VAR_053670
	Natural variant	443	1	H → Y. Corresponds to variant rs34746107 [ dbSNP | Ensembl ].		VAR_053671

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (2.3kb) [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 49B0DECA3D930A45	FASTA	559	61,477
	10 20 30 40 50 60 MAPTLQQAYR RRWWMACTAV LENLFFSAVL LGWGSLLIIL KNEGFYSSTC PAESSTNTTQ 70 80 90 100 110 120 DEQRRWPGCD QQDEMLNLGF TIGSFVLSAT TLPLGILMDR FGPRPVRLVG SACFTASCTL 130 140 150 160 170 180 MALASRDVEA LSPLIFLALS LNGFGGICLT FTSLTLPNMF GNLRSTLMAL MIGSYASSAI 190 200 210 220 230 240 TFPGIKLIYD AGVAFVVIMF TWSGLACLIF LNCTLNWPIE AFPAPEEVNY TKKIKLSGLA 250 260 270 280 290 300 LDHKVTGDLF YTHVTTMGQR LSQKAPSLED GSDAFMSPQD VRGTSENLPE RSVPLRKSLC 310 320 330 340 350 360 SPTFLWSLLT MGMTQLRIIF YMAAVNKMLE YLVTGGQEHE TNEQQQKVAE TVGFYSSVFG 370 380 390 400 410 420 AMQLLCLLTC PLIGYIMDWR IKDCVDAPTQ GTVLGDARDG VATKSIRPRY CKIQKLTNAI 430 440 450 460 470 480 SAFTLTNLLL VGFGITCLIN NLHLQFVTFV LHTIVRGFFH SACGSLYAAV FPSNHFGTLT 490 500 510 520 530 540 GLQSLISAVF ALLQQPLFMA MVGPLKGEPF WVNLGLLLFS LLGFLLPSYL FYYRARLQQE 550 YAANGMGPLK VLSGSEVTA
	Isoform 2 (5kb) [UniParc]. Checksum: CC4C698554DF06D1	FASTA	560	61,051
	10 20 30 40 50 60 MAPTLQQAYR RRWWMACTAV LENLFFSAVL LGWGSLLIIL KNEGFYSSTC PAESSTNTTQ 70 80 90 100 110 120 DEQRRWPGCD QQDEMLNLGF TIGSFVLSAT TLPLGILMDR FGPRPVRLVG SACFTASCTL 130 140 150 160 170 180 MALASRDVEA LSPLIFLALS LNGFGGICLT FTSLTLPNMF GNLRSTLMAL MIGSYASSAI 190 200 210 220 230 240 TFPGIKLIYD AGVAFVVIMF TWSGLACLIF LNCTLNWPIE AFPAPEEVNY TKKIKLSGLA 250 260 270 280 290 300 LDHKVTGDLF YTHVTTMGQR LSQKAPSLED GSDAFMSPQD VRGTSENLPE RSVPLRKSLC 310 320 330 340 350 360 SPTFLWSLLT MGMTQLRIIF YMAAVNKMLE YLVTGGQEHE TNEQQQKVAE TVGFYSSVFG 370 380 390 400 410 420 AMQLLCLLTC PLIGYIMDWR IKDCVDAPTQ GTVLGDARDG VATKSIRPRY CKIQKLTNAI 430 440 450 460 470 480 SAFTLTNLLL VGFGITCLIN NLHLQFVTFV LHTIVRGFFH SACGSLYAAV FPSNHFGTLT 490 500 510 520 530 540 GLQSLISAVF ALLQQPLFMA MVGPLKGEPF WVRARVGVGG AGATLLGAGV GPCMWCHPSL 550 560 ISARGTSEVS NLQVSKLSAF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"cDNA sequencing and analysis of POV1 (PB39): a novel gene up-regulated in prostate cancer." Cole K.A., Chuaqui R.F., Katz K., Pack S., Zhuang Z., Cole C.E., Lyne J.C., Linehan W.M., Liotta L.A., Emmert-Buck M.R. Genomics 51:282-287(1998) [PubMed: 9722952] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, TISSUE SPECIFICITY.
[2]	"Identification of a novel system L amino acid transporter structurally distinct from heterodimeric amino acid transporters." Babu E., Kanai Y., Chairoungdua A., Kim D.K., Iribe Y., Tangtrongsup S., Jutabha P., Li Y., Ahmed N., Sakamoto S., Anzai N., Nagamori S., Endou H. J. Biol. Chem. 278:43838-43845(2003) [PubMed: 12930836] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY. Tissue: Liver.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Colon.
[4]	"Identification of a novel transcript up-regulated in a clinically aggressive prostate carcinoma." Chuaqui R.F., Englert C.R., Strup S.E., Vocke C.D., Zhuang Z., Duray P.H., Bostwick D.G., Linehan W.M., Liotta L.A., Emmert-Buck M.R. Urology 50:302-307(1997) [PubMed: 9255310] [Abstract] Cited for: PARTIAL NUCLEOTIDE SEQUENCE (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
[5]	"New insights into testicular germ cell tumorigenesis from gene expression profiling." Skotheim R.I., Monni O., Mousses S., Fossaa S.D., Kallioniemi O.-P., Lothe R.A., Kallioniemi A. Cancer Res. 62:2359-2364(2002) [PubMed: 11956097] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF045584 mRNA. Translation: AAC33004.1. AB103033 mRNA. Translation: BAD00152.1. BC001639 mRNA. Translation: AAH01639.1.
IPI	IPI00021075. IPI00479732.
RefSeq	NP_001185739.1. NM_001198810.1. NP_003618.1. NM_003627.5.
UniGene	Hs.591952.
3D structure databases
ProteinModelPortal	O75387.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-47272N.
STRING	O75387.
Protein family/group databases
TCDB	2.A.1.44.1. major facilitator superfamily (MFS).
PTM databases
PhosphoSite	O75387.
Proteomic databases
PRIDE	O75387.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000278426; ENSP00000278426; ENSG00000149150.
GeneID	8501.
KEGG	hsa:8501.
UCSC	uc001nkk.1. human.
Organism-specific databases
CTD	8501.
GeneCards	GC11M057252.
H-InvDB	HIX0009635.
HGNC	HGNC:9225. SLC43A1.
HPA	HPA018813. HPA018826.
MIM	603733. gene.
neXtProt	NX_O75387.
PharmGKB	PA33549.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG13750.
GeneTree	ENSGT00530000063043.
HOGENOM	HBG444314.
HOVERGEN	HBG072879.
InParanoid	O75387.
OMA	SYLFYYR.
OrthoDB	EOG42FSHN.
PhylomeDB	O75387.
Enzyme and pathway databases
Reactome	REACT_15518. Transmembrane transport of small molecules. REACT_19419. Amino acid and oligopeptide SLC transporters.
Gene expression databases
ArrayExpress	O75387.
Bgee	O75387.
CleanEx	HS_SLC43A1.
Genevestigator	O75387.
GermOnline	ENSG00000149150. Homo sapiens.
Family and domain databases
InterPro	IPR011701. MFS. IPR016196. MFS_dom_general_subst_transpt. [Graphical view]
KO	K08228.
Pfam	PF07690. MFS_1. 1 hit. [Graphical view]
SUPFAM	SSF103473. MFS_gen_substrate_transporter. 1 hit.
ProtoNet	Search...
Other
NextBio	31811.
SOURCE	Search...

Entry information

Entry name

LAT3_HUMAN

Accession

Primary (citable) accession number: O75387

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 23, 2004
Last sequence update:	November 1, 1998
Last modified:	January 25, 2012
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.