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O75387

- LAT3_HUMAN

UniProt

O75387 - LAT3_HUMAN

Protein

Large neutral amino acids transporter small subunit 3

Gene

SLC43A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Sodium-independent, high affinity transport of large neutral amino acids. Has narrower substrate selectivity compared to SLC7A5 and SLC7A8 and mainly transports branched-chain amino acids and phenylalanine. Plays a role in the development of human prostate cancer, from prostatic intraepithelial neoplasia to invasive prostate cancer.4 Publications

    GO - Molecular functioni

    1. L-amino acid transmembrane transporter activity Source: Ensembl
    2. neutral amino acid transmembrane transporter activity Source: UniProtKB

    GO - Biological processi

    1. amino acid transport Source: Reactome
    2. ion transport Source: Reactome
    3. neutral amino acid transport Source: UniProtKB
    4. transmembrane transport Source: Reactome

    Keywords - Biological processi

    Amino-acid transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_13796. Amino acid transport across the plasma membrane.

    Protein family/group databases

    TCDBi2.A.1.44.1. the major facilitator superfamily (mfs).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Large neutral amino acids transporter small subunit 3
    Alternative name(s):
    L-type amino acid transporter 3
    Prostate cancer overexpressed gene 1 protein
    Solute carrier family 43 member 1
    Gene namesi
    Name:SLC43A1Imported
    Synonyms:LAT3Imported, PB391 Publication, POV11 Publication
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:9225. SLC43A1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: UniProtKB
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33549.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 559559Large neutral amino acids transporter small subunit 3PRO_0000218640Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi57 – 571N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi212 – 2121N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi229 – 2291N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiO75387.
    PaxDbiO75387.
    PRIDEiO75387.

    PTM databases

    PhosphoSiteiO75387.

    Expressioni

    Tissue specificityi

    In adults, found in all tissues examined with highest expression in pancreas. In fetus, highest expression in liver and lower levels in kidney, and lung. High levels found in prostate cancer cells.4 Publications

    Gene expression databases

    ArrayExpressiO75387.
    BgeeiO75387.
    CleanExiHS_SLC43A1.
    GenevestigatoriO75387.

    Organism-specific databases

    HPAiHPA018813.
    HPA018826.

    Interactioni

    Protein-protein interaction databases

    BioGridi114073. 1 interaction.
    DIPiDIP-47272N.
    IntActiO75387. 1 interaction.
    STRINGi9606.ENSP00000278426.

    Structurei

    3D structure databases

    ProteinModelPortaliO75387.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei20 – 4021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei78 – 9821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei105 – 12420HelicalSequence AnalysisAdd
    BLAST
    Transmembranei131 – 15121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei168 – 18821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei191 – 21121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei304 – 32421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei357 – 37721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei419 – 43921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei446 – 46621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei485 – 50521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei510 – 53021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG71084.
    HOGENOMiHOG000231937.
    HOVERGENiHBG072879.
    InParanoidiO75387.
    KOiK08228.
    OMAiNWPVEAF.
    OrthoDBiEOG712TWX.
    PhylomeDBiO75387.
    TreeFamiTF328358.

    Family and domain databases

    InterProiIPR011701. MFS.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view]
    PfamiPF07690. MFS_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 3 hits.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 11 Publication (identifier: O75387-1) [UniParc]FASTAAdd to Basket

    Also known as: 2.3kb1 Publication

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAPTLQQAYR RRWWMACTAV LENLFFSAVL LGWGSLLIIL KNEGFYSSTC    50
    PAESSTNTTQ DEQRRWPGCD QQDEMLNLGF TIGSFVLSAT TLPLGILMDR 100
    FGPRPVRLVG SACFTASCTL MALASRDVEA LSPLIFLALS LNGFGGICLT 150
    FTSLTLPNMF GNLRSTLMAL MIGSYASSAI TFPGIKLIYD AGVAFVVIMF 200
    TWSGLACLIF LNCTLNWPIE AFPAPEEVNY TKKIKLSGLA LDHKVTGDLF 250
    YTHVTTMGQR LSQKAPSLED GSDAFMSPQD VRGTSENLPE RSVPLRKSLC 300
    SPTFLWSLLT MGMTQLRIIF YMAAVNKMLE YLVTGGQEHE TNEQQQKVAE 350
    TVGFYSSVFG AMQLLCLLTC PLIGYIMDWR IKDCVDAPTQ GTVLGDARDG 400
    VATKSIRPRY CKIQKLTNAI SAFTLTNLLL VGFGITCLIN NLHLQFVTFV 450
    LHTIVRGFFH SACGSLYAAV FPSNHFGTLT GLQSLISAVF ALLQQPLFMA 500
    MVGPLKGEPF WVNLGLLLFS LLGFLLPSYL FYYRARLQQE YAANGMGPLK 550
    VLSGSEVTA 559
    Length:559
    Mass (Da):61,477
    Last modified:November 1, 1998 - v1
    Checksum:i49B0DECA3D930A45
    GO
    Isoform 21 Publication (identifier: O75387-2) [UniParc]FASTAAdd to Basket

    Also known as: 5kb1 Publication

    The sequence of this isoform differs from the canonical sequence as follows:
         513-559: NLGLLLFSLL...KVLSGSEVTA → RARVGVGGAG...NLQVSKLSAF

    Show »
    Length:560
    Mass (Da):61,051
    Checksum:iCC4C698554DF06D1
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti238 – 2381G → V.
    Corresponds to variant rs17151933 [ dbSNP | Ensembl ].
    VAR_053670
    Natural varianti443 – 4431H → Y.
    Corresponds to variant rs34746107 [ dbSNP | Ensembl ].
    VAR_053671

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei513 – 55947NLGLL…SEVTA → RARVGVGGAGATLLGAGVGP CMWCHPSLISARGTSEVSNL QVSKLSAF in isoform 2. 1 PublicationVSP_051620Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF045584 mRNA. Translation: AAC33004.1.
    AB103033 mRNA. Translation: BAD00152.1.
    BC001639 mRNA. Translation: AAH01639.1.
    CCDSiCCDS7958.1. [O75387-1]
    RefSeqiNP_001185739.1. NM_001198810.1. [O75387-1]
    NP_003618.1. NM_003627.5. [O75387-1]
    UniGeneiHs.591952.
    Hs.735724.

    Genome annotation databases

    EnsembliENST00000278426; ENSP00000278426; ENSG00000149150. [O75387-1]
    ENST00000528450; ENSP00000435673; ENSG00000149150. [O75387-1]
    GeneIDi8501.
    KEGGihsa:8501.
    UCSCiuc001nkk.3. human. [O75387-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF045584 mRNA. Translation: AAC33004.1 .
    AB103033 mRNA. Translation: BAD00152.1 .
    BC001639 mRNA. Translation: AAH01639.1 .
    CCDSi CCDS7958.1. [O75387-1 ]
    RefSeqi NP_001185739.1. NM_001198810.1. [O75387-1 ]
    NP_003618.1. NM_003627.5. [O75387-1 ]
    UniGenei Hs.591952.
    Hs.735724.

    3D structure databases

    ProteinModelPortali O75387.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114073. 1 interaction.
    DIPi DIP-47272N.
    IntActi O75387. 1 interaction.
    STRINGi 9606.ENSP00000278426.

    Chemistry

    BindingDBi O75387.

    Protein family/group databases

    TCDBi 2.A.1.44.1. the major facilitator superfamily (mfs).

    PTM databases

    PhosphoSitei O75387.

    Proteomic databases

    MaxQBi O75387.
    PaxDbi O75387.
    PRIDEi O75387.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000278426 ; ENSP00000278426 ; ENSG00000149150 . [O75387-1 ]
    ENST00000528450 ; ENSP00000435673 ; ENSG00000149150 . [O75387-1 ]
    GeneIDi 8501.
    KEGGi hsa:8501.
    UCSCi uc001nkk.3. human. [O75387-1 ]

    Organism-specific databases

    CTDi 8501.
    GeneCardsi GC11M057252.
    HGNCi HGNC:9225. SLC43A1.
    HPAi HPA018813.
    HPA018826.
    MIMi 603733. gene.
    neXtProti NX_O75387.
    PharmGKBi PA33549.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG71084.
    HOGENOMi HOG000231937.
    HOVERGENi HBG072879.
    InParanoidi O75387.
    KOi K08228.
    OMAi NWPVEAF.
    OrthoDBi EOG712TWX.
    PhylomeDBi O75387.
    TreeFami TF328358.

    Enzyme and pathway databases

    Reactomei REACT_13796. Amino acid transport across the plasma membrane.

    Miscellaneous databases

    ChiTaRSi SLC43A1. human.
    GeneWikii SLC43A1.
    GenomeRNAii 8501.
    NextBioi 31811.
    PROi O75387.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O75387.
    Bgeei O75387.
    CleanExi HS_SLC43A1.
    Genevestigatori O75387.

    Family and domain databases

    InterProi IPR011701. MFS.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view ]
    Pfami PF07690. MFS_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 3 hits.
    ProtoNeti Search...

    Publicationsi

    1. "cDNA sequencing and analysis of POV1 (PB39): a novel gene up-regulated in prostate cancer."
      Cole K.A., Chuaqui R.F., Katz K., Pack S., Zhuang Z., Cole C.E., Lyne J.C., Linehan W.M., Liotta L.A., Emmert-Buck M.R.
      Genomics 51:282-287(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, TISSUE SPECIFICITY.
    2. "Identification of a novel system L amino acid transporter structurally distinct from heterodimeric amino acid transporters."
      Babu E., Kanai Y., Chairoungdua A., Kim D.K., Iribe Y., Tangtrongsup S., Jutabha P., Li Y., Ahmed N., Sakamoto S., Anzai N., Nagamori S., Endou H.
      J. Biol. Chem. 278:43838-43845(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
      Tissue: LiverImported.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: ColonImported.
    4. "Identification of a novel transcript up-regulated in a clinically aggressive prostate carcinoma."
      Chuaqui R.F., Englert C.R., Strup S.E., Vocke C.D., Zhuang Z., Duray P.H., Bostwick D.G., Linehan W.M., Liotta L.A., Emmert-Buck M.R.
      Urology 50:302-307(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL NUCLEOTIDE SEQUENCE (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
    5. "New insights into testicular germ cell tumorigenesis from gene expression profiling."
      Skotheim R.I., Monni O., Mousses S., Fossaa S.D., Kallioniemi O.-P., Lothe R.A., Kallioniemi A.
      Cancer Res. 62:2359-2364(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiLAT3_HUMAN
    AccessioniPrimary (citable) accession number: O75387
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 23, 2004
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Up-regulated in early prostate cancer development with highest expression level in seminomas of testicular germ cell tumors.2 Publications

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3