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O75387

- LAT3_HUMAN

UniProt

O75387 - LAT3_HUMAN

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Protein
Large neutral amino acids transporter small subunit 3
Gene
SLC43A1, LAT3, PB39, POV1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Sodium-independent, high affinity transport of large neutral amino acids. Has narrower substrate selectivity compared to SLC7A5 and SLC7A8 and mainly transports branched-chain amino acids and phenylalanine. Plays a role in the development of human prostate cancer, from prostatic intraepithelial neoplasia to invasive prostate cancer.4 Publications

GO - Molecular functioni

  1. L-amino acid transmembrane transporter activity Source: Ensembl
  2. neutral amino acid transmembrane transporter activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. amino acid transport Source: Reactome
  2. ion transport Source: Reactome
  3. neutral amino acid transport Source: UniProtKB
  4. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

ReactomeiREACT_13796. Amino acid transport across the plasma membrane.

Protein family/group databases

TCDBi2.A.1.44.1. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Large neutral amino acids transporter small subunit 3
Alternative name(s):
L-type amino acid transporter 3
Prostate cancer overexpressed gene 1 protein
Solute carrier family 43 member 1
Gene namesi
Name:SLC43A1
Synonyms:LAT3, PB39, POV1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:9225. SLC43A1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei20 – 4021Helical; Reviewed prediction
Add
BLAST
Transmembranei78 – 9821Helical; Reviewed prediction
Add
BLAST
Transmembranei105 – 12420Helical; Reviewed prediction
Add
BLAST
Transmembranei131 – 15121Helical; Reviewed prediction
Add
BLAST
Transmembranei168 – 18821Helical; Reviewed prediction
Add
BLAST
Transmembranei191 – 21121Helical; Reviewed prediction
Add
BLAST
Transmembranei304 – 32421Helical; Reviewed prediction
Add
BLAST
Transmembranei357 – 37721Helical; Reviewed prediction
Add
BLAST
Transmembranei419 – 43921Helical; Reviewed prediction
Add
BLAST
Transmembranei446 – 46621Helical; Reviewed prediction
Add
BLAST
Transmembranei485 – 50521Helical; Reviewed prediction
Add
BLAST
Transmembranei510 – 53021Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: UniProtKB
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33549.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 559559Large neutral amino acids transporter small subunit 3
PRO_0000218640Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi57 – 571N-linked (GlcNAc...) Reviewed prediction
Glycosylationi212 – 2121N-linked (GlcNAc...) Reviewed prediction
Glycosylationi229 – 2291N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiO75387.
PaxDbiO75387.
PRIDEiO75387.

PTM databases

PhosphoSiteiO75387.

Expressioni

Tissue specificityi

In adults, found in all tissues examined with highest expression in pancreas. In fetus, highest expression in liver and lower levels in kidney, and lung. High levels found in prostate cancer cells.4 Publications

Gene expression databases

ArrayExpressiO75387.
BgeeiO75387.
CleanExiHS_SLC43A1.
GenevestigatoriO75387.

Organism-specific databases

HPAiHPA018813.
HPA018826.

Interactioni

Protein-protein interaction databases

BioGridi114073. 1 interaction.
DIPiDIP-47272N.
STRINGi9606.ENSP00000278426.

Structurei

3D structure databases

ProteinModelPortaliO75387.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG71084.
HOGENOMiHOG000231937.
HOVERGENiHBG072879.
InParanoidiO75387.
KOiK08228.
OMAiNWPVEAF.
OrthoDBiEOG712TWX.
PhylomeDBiO75387.
TreeFamiTF328358.

Family and domain databases

InterProiIPR011701. MFS.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 11 Publication (identifier: O75387-1) [UniParc]FASTAAdd to Basket

Also known as: 2.3kb

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAPTLQQAYR RRWWMACTAV LENLFFSAVL LGWGSLLIIL KNEGFYSSTC    50
PAESSTNTTQ DEQRRWPGCD QQDEMLNLGF TIGSFVLSAT TLPLGILMDR 100
FGPRPVRLVG SACFTASCTL MALASRDVEA LSPLIFLALS LNGFGGICLT 150
FTSLTLPNMF GNLRSTLMAL MIGSYASSAI TFPGIKLIYD AGVAFVVIMF 200
TWSGLACLIF LNCTLNWPIE AFPAPEEVNY TKKIKLSGLA LDHKVTGDLF 250
YTHVTTMGQR LSQKAPSLED GSDAFMSPQD VRGTSENLPE RSVPLRKSLC 300
SPTFLWSLLT MGMTQLRIIF YMAAVNKMLE YLVTGGQEHE TNEQQQKVAE 350
TVGFYSSVFG AMQLLCLLTC PLIGYIMDWR IKDCVDAPTQ GTVLGDARDG 400
VATKSIRPRY CKIQKLTNAI SAFTLTNLLL VGFGITCLIN NLHLQFVTFV 450
LHTIVRGFFH SACGSLYAAV FPSNHFGTLT GLQSLISAVF ALLQQPLFMA 500
MVGPLKGEPF WVNLGLLLFS LLGFLLPSYL FYYRARLQQE YAANGMGPLK 550
VLSGSEVTA 559
Length:559
Mass (Da):61,477
Last modified:November 1, 1998 - v1
Checksum:i49B0DECA3D930A45
GO
Isoform 21 Publication (identifier: O75387-2) [UniParc]FASTAAdd to Basket

Also known as: 5kb

The sequence of this isoform differs from the canonical sequence as follows:
     513-559: NLGLLLFSLL...KVLSGSEVTA → RARVGVGGAG...NLQVSKLSAF

Show »
Length:560
Mass (Da):61,051
Checksum:iCC4C698554DF06D1
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti238 – 2381G → V.
Corresponds to variant rs17151933 [ dbSNP | Ensembl ].
VAR_053670
Natural varianti443 – 4431H → Y.
Corresponds to variant rs34746107 [ dbSNP | Ensembl ].
VAR_053671

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei513 – 55947NLGLL…SEVTA → RARVGVGGAGATLLGAGVGP CMWCHPSLISARGTSEVSNL QVSKLSAF in isoform 2. 1 Publication
VSP_051620Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF045584 mRNA. Translation: AAC33004.1.
AB103033 mRNA. Translation: BAD00152.1.
BC001639 mRNA. Translation: AAH01639.1.
CCDSiCCDS7958.1. [O75387-1]
RefSeqiNP_001185739.1. NM_001198810.1. [O75387-1]
NP_003618.1. NM_003627.5. [O75387-1]
UniGeneiHs.591952.
Hs.735724.

Genome annotation databases

EnsembliENST00000278426; ENSP00000278426; ENSG00000149150. [O75387-1]
ENST00000528450; ENSP00000435673; ENSG00000149150. [O75387-1]
GeneIDi8501.
KEGGihsa:8501.
UCSCiuc001nkk.3. human. [O75387-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF045584 mRNA. Translation: AAC33004.1 .
AB103033 mRNA. Translation: BAD00152.1 .
BC001639 mRNA. Translation: AAH01639.1 .
CCDSi CCDS7958.1. [O75387-1 ]
RefSeqi NP_001185739.1. NM_001198810.1. [O75387-1 ]
NP_003618.1. NM_003627.5. [O75387-1 ]
UniGenei Hs.591952.
Hs.735724.

3D structure databases

ProteinModelPortali O75387.
ModBasei Search...

Protein-protein interaction databases

BioGridi 114073. 1 interaction.
DIPi DIP-47272N.
STRINGi 9606.ENSP00000278426.

Chemistry

BindingDBi O75387.

Protein family/group databases

TCDBi 2.A.1.44.1. the major facilitator superfamily (mfs).

PTM databases

PhosphoSitei O75387.

Proteomic databases

MaxQBi O75387.
PaxDbi O75387.
PRIDEi O75387.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000278426 ; ENSP00000278426 ; ENSG00000149150 . [O75387-1 ]
ENST00000528450 ; ENSP00000435673 ; ENSG00000149150 . [O75387-1 ]
GeneIDi 8501.
KEGGi hsa:8501.
UCSCi uc001nkk.3. human. [O75387-1 ]

Organism-specific databases

CTDi 8501.
GeneCardsi GC11M057252.
HGNCi HGNC:9225. SLC43A1.
HPAi HPA018813.
HPA018826.
MIMi 603733. gene.
neXtProti NX_O75387.
PharmGKBi PA33549.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG71084.
HOGENOMi HOG000231937.
HOVERGENi HBG072879.
InParanoidi O75387.
KOi K08228.
OMAi NWPVEAF.
OrthoDBi EOG712TWX.
PhylomeDBi O75387.
TreeFami TF328358.

Enzyme and pathway databases

Reactomei REACT_13796. Amino acid transport across the plasma membrane.

Miscellaneous databases

ChiTaRSi SLC43A1. human.
GeneWikii SLC43A1.
GenomeRNAii 8501.
NextBioi 31811.
PROi O75387.
SOURCEi Search...

Gene expression databases

ArrayExpressi O75387.
Bgeei O75387.
CleanExi HS_SLC43A1.
Genevestigatori O75387.

Family and domain databases

InterProi IPR011701. MFS.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view ]
Pfami PF07690. MFS_1. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 3 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA sequencing and analysis of POV1 (PB39): a novel gene up-regulated in prostate cancer."
    Cole K.A., Chuaqui R.F., Katz K., Pack S., Zhuang Z., Cole C.E., Lyne J.C., Linehan W.M., Liotta L.A., Emmert-Buck M.R.
    Genomics 51:282-287(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, TISSUE SPECIFICITY.
  2. "Identification of a novel system L amino acid transporter structurally distinct from heterodimeric amino acid transporters."
    Babu E., Kanai Y., Chairoungdua A., Kim D.K., Iribe Y., Tangtrongsup S., Jutabha P., Li Y., Ahmed N., Sakamoto S., Anzai N., Nagamori S., Endou H.
    J. Biol. Chem. 278:43838-43845(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
    Tissue: Liver.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Colon.
  4. "Identification of a novel transcript up-regulated in a clinically aggressive prostate carcinoma."
    Chuaqui R.F., Englert C.R., Strup S.E., Vocke C.D., Zhuang Z., Duray P.H., Bostwick D.G., Linehan W.M., Liotta L.A., Emmert-Buck M.R.
    Urology 50:302-307(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL NUCLEOTIDE SEQUENCE (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
  5. "New insights into testicular germ cell tumorigenesis from gene expression profiling."
    Skotheim R.I., Monni O., Mousses S., Fossaa S.D., Kallioniemi O.-P., Lothe R.A., Kallioniemi A.
    Cancer Res. 62:2359-2364(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiLAT3_HUMAN
AccessioniPrimary (citable) accession number: O75387
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: November 1, 1998
Last modified: September 3, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Up-regulated in early prostate cancer development with highest expression level in seminomas of testicular germ cell tumors.2 Publications

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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