Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O75387 (LAT3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Large neutral amino acids transporter small subunit 3
Alternative name(s):
L-type amino acid transporter 3
Prostate cancer overexpressed gene 1 protein
Solute carrier family 43 member 1
Gene names
Name:SLC43A1
Synonyms:LAT3, PB39, POV1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length559 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Sodium-independent, high affinity transport of large neutral amino acids. Has narrower substrate selectivity compared to SLC7A5 and SLC7A8 and mainly transports branched-chain amino acids and phenylalanine. Plays a role in the development of human prostate cancer, from prostatic intraepithelial neoplasia to invasive prostate cancer. Ref.1 Ref.2 Ref.4 Ref.5

Subcellular location

Membrane; Multi-pass membrane protein Probable.

Tissue specificity

In adults, found in all tissues examined with highest expression in pancreas. In fetus, highest expression in liver and lower levels in kidney, and lung. High levels found in prostate cancer cells. Ref.1 Ref.2 Ref.4 Ref.5

Miscellaneous

Up-regulated in early prostate cancer development with highest expression level in seminomas of testicular germ cell tumors. Ref.4 Ref.5

Sequence similarities

Belongs to the SLC43A transporter (TC 2.A.1.44) family. [View classification]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 Ref.1 (identifier: O75387-1)

Also known as: 2.3kb;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 Ref.1 (identifier: O75387-2)

Also known as: 5kb;

The sequence of this isoform differs from the canonical sequence as follows:
     513-559: NLGLLLFSLL...KVLSGSEVTA → RARVGVGGAG...NLQVSKLSAF

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 559559Large neutral amino acids transporter small subunit 3
PRO_0000218640

Regions

Transmembrane20 – 4021Helical; Potential
Transmembrane78 – 9821Helical; Potential
Transmembrane105 – 12420Helical; Potential
Transmembrane131 – 15121Helical; Potential
Transmembrane168 – 18821Helical; Potential
Transmembrane191 – 21121Helical; Potential
Transmembrane304 – 32421Helical; Potential
Transmembrane357 – 37721Helical; Potential
Transmembrane419 – 43921Helical; Potential
Transmembrane446 – 46621Helical; Potential
Transmembrane485 – 50521Helical; Potential
Transmembrane510 – 53021Helical; Potential

Amino acid modifications

Glycosylation571N-linked (GlcNAc...) Potential
Glycosylation2121N-linked (GlcNAc...) Potential
Glycosylation2291N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence513 – 55947NLGLL…SEVTA → RARVGVGGAGATLLGAGVGP CMWCHPSLISARGTSEVSNL QVSKLSAF in isoform 2. Ref.1
VSP_051620
Natural variant2381G → V.
Corresponds to variant rs17151933 [ dbSNP | Ensembl ].
VAR_053670
Natural variant4431H → Y.
Corresponds to variant rs34746107 [ dbSNP | Ensembl ].
VAR_053671

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (2.3kb) [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 49B0DECA3D930A45

FASTA55961,477
        10         20         30         40         50         60 
MAPTLQQAYR RRWWMACTAV LENLFFSAVL LGWGSLLIIL KNEGFYSSTC PAESSTNTTQ 

        70         80         90        100        110        120 
DEQRRWPGCD QQDEMLNLGF TIGSFVLSAT TLPLGILMDR FGPRPVRLVG SACFTASCTL 

       130        140        150        160        170        180 
MALASRDVEA LSPLIFLALS LNGFGGICLT FTSLTLPNMF GNLRSTLMAL MIGSYASSAI 

       190        200        210        220        230        240 
TFPGIKLIYD AGVAFVVIMF TWSGLACLIF LNCTLNWPIE AFPAPEEVNY TKKIKLSGLA 

       250        260        270        280        290        300 
LDHKVTGDLF YTHVTTMGQR LSQKAPSLED GSDAFMSPQD VRGTSENLPE RSVPLRKSLC 

       310        320        330        340        350        360 
SPTFLWSLLT MGMTQLRIIF YMAAVNKMLE YLVTGGQEHE TNEQQQKVAE TVGFYSSVFG 

       370        380        390        400        410        420 
AMQLLCLLTC PLIGYIMDWR IKDCVDAPTQ GTVLGDARDG VATKSIRPRY CKIQKLTNAI 

       430        440        450        460        470        480 
SAFTLTNLLL VGFGITCLIN NLHLQFVTFV LHTIVRGFFH SACGSLYAAV FPSNHFGTLT 

       490        500        510        520        530        540 
GLQSLISAVF ALLQQPLFMA MVGPLKGEPF WVNLGLLLFS LLGFLLPSYL FYYRARLQQE 

       550 
YAANGMGPLK VLSGSEVTA 

« Hide

Isoform 2 (5kb) [UniParc].

Checksum: CC4C698554DF06D1
Show »

FASTA56061,051

References

« Hide 'large scale' references
[1]"cDNA sequencing and analysis of POV1 (PB39): a novel gene up-regulated in prostate cancer."
Cole K.A., Chuaqui R.F., Katz K., Pack S., Zhuang Z., Cole C.E., Lyne J.C., Linehan W.M., Liotta L.A., Emmert-Buck M.R.
Genomics 51:282-287(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, TISSUE SPECIFICITY.
[2]"Identification of a novel system L amino acid transporter structurally distinct from heterodimeric amino acid transporters."
Babu E., Kanai Y., Chairoungdua A., Kim D.K., Iribe Y., Tangtrongsup S., Jutabha P., Li Y., Ahmed N., Sakamoto S., Anzai N., Nagamori S., Endou H.
J. Biol. Chem. 278:43838-43845(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
Tissue: Liver.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Colon.
[4]"Identification of a novel transcript up-regulated in a clinically aggressive prostate carcinoma."
Chuaqui R.F., Englert C.R., Strup S.E., Vocke C.D., Zhuang Z., Duray P.H., Bostwick D.G., Linehan W.M., Liotta L.A., Emmert-Buck M.R.
Urology 50:302-307(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: PARTIAL NUCLEOTIDE SEQUENCE (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
[5]"New insights into testicular germ cell tumorigenesis from gene expression profiling."
Skotheim R.I., Monni O., Mousses S., Fossaa S.D., Kallioniemi O.-P., Lothe R.A., Kallioniemi A.
Cancer Res. 62:2359-2364(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF045584 mRNA. Translation: AAC33004.1.
AB103033 mRNA. Translation: BAD00152.1.
BC001639 mRNA. Translation: AAH01639.1.
RefSeqNP_001185739.1. NM_001198810.1.
NP_003618.1. NM_003627.5.
UniGeneHs.591952.
Hs.735724.

3D structure databases

ProteinModelPortalO75387.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114073. 1 interaction.
DIPDIP-47272N.
STRING9606.ENSP00000278426.

Chemistry

BindingDBO75387.

Protein family/group databases

TCDB2.A.1.44.1. the major facilitator superfamily (mfs).

PTM databases

PhosphoSiteO75387.

Proteomic databases

PaxDbO75387.
PRIDEO75387.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000278426; ENSP00000278426; ENSG00000149150. [O75387-1]
ENST00000528450; ENSP00000435673; ENSG00000149150. [O75387-1]
GeneID8501.
KEGGhsa:8501.
UCSCuc001nkk.3. human. [O75387-1]

Organism-specific databases

CTD8501.
GeneCardsGC11M057252.
HGNCHGNC:9225. SLC43A1.
HPAHPA018813.
HPA018826.
MIM603733. gene.
neXtProtNX_O75387.
PharmGKBPA33549.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG71084.
HOGENOMHOG000231937.
HOVERGENHBG072879.
InParanoidO75387.
KOK08228.
OMANWPVEAF.
OrthoDBEOG712TWX.
PhylomeDBO75387.
TreeFamTF328358.

Enzyme and pathway databases

ReactomeREACT_15518. Transmembrane transport of small molecules.
REACT_19419. Amino acid and oligopeptide SLC transporters.

Gene expression databases

ArrayExpressO75387.
BgeeO75387.
CleanExHS_SLC43A1.
GenevestigatorO75387.

Family and domain databases

InterProIPR011701. MFS.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
PfamPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMSSF103473. SSF103473. 3 hits.
ProtoNetSearch...

Other

ChiTaRSSLC43A1. human.
GeneWikiSLC43A1.
GenomeRNAi8501.
NextBio31811.
PROO75387.
SOURCESearch...

Entry information

Entry nameLAT3_HUMAN
AccessionPrimary (citable) accession number: O75387
Entry history
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: November 1, 1998
Last modified: April 16, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM