##gff-version 3
O75386	UniProtKB	Chain	1	442	.	.	.	ID=PRO_0000186470;Note=Tubby-related protein 3	
O75386	UniProtKB	Region	23	68	.	.	.	Note=Required for association with the IFT complex A (IFT-A)	
O75386	UniProtKB	Region	101	177	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
O75386	UniProtKB	Compositional bias	107	122	.	.	.	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
O75386	UniProtKB	Compositional bias	124	138	.	.	.	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
O75386	UniProtKB	Compositional bias	140	176	.	.	.	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
O75386	UniProtKB	Alternative sequence	1	19	.	.	.	ID=VSP_055761;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039	
O75386	UniProtKB	Alternative sequence	165	189	.	.	.	ID=VSP_055762;Note=In isoform 3. DTGTSGSATAAQPADNLLGDIDDLE->FSSFCQKTEDTGYRHFRFCYCRPTS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039	
O75386	UniProtKB	Alternative sequence	190	442	.	.	.	ID=VSP_055763;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039	
O75386	UniProtKB	Alternative sequence	437	442	.	.	.	ID=VSP_054752;Note=In isoform 2. SKLACE->KCIQTLRMQELCELHRQHHSAASLVHRTVCQRWVGHPWRLLPQTSLLWTDLSPPPVVPAPHQISM;Ontology_term=ECO:0000305;evidence=ECO:0000305	
O75386	UniProtKB	Natural variant	24	442	.	.	.	ID=VAR_087378;Note=In HRCDF. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:35397207;Dbxref=PMID:35397207	
O75386	UniProtKB	Natural variant	204	204	.	.	.	ID=VAR_087379;Note=In HRCDF%3B uncertain significance. C->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:35397207;Dbxref=dbSNP:rs547315819,PMID:35397207	
O75386	UniProtKB	Natural variant	408	408	.	.	.	ID=VAR_087380;Note=In HRCDF%3B almost complete loss of ciliary localization. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:35397207;Dbxref=dbSNP:rs761172007,PMID:35397207	
O75386	UniProtKB	Mutagenesis	24	34	.	.	.	Note=In mut12%3B abolishes association with the IFT complex A (IFT-A) without affecting phosphoinositide binding. Impaired localization to cilia. RQAKLDYQRLL->AQAAADYAALA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20889716;Dbxref=PMID:20889716	
O75386	UniProtKB	Mutagenesis	268	270	.	.	.	Note=In TULP3KR%3B abolishes phosphoinositide binding and impairs localization to cilia. Still associates with the IFT complex A (IFT-A). KLR->ALA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20889716;Dbxref=PMID:20889716	
O75386	UniProtKB	Sequence conflict	168	181	.	.	.	Note=TSGSATAAQPADNL->IPVLLLPPNQLITF;Ontology_term=ECO:0000305;evidence=ECO:0000305	
O75386	UniProtKB	Sequence conflict	187	187	.	.	.	Note=D->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305	
O75386	UniProtKB	Sequence conflict	193	194	.	.	.	Note=YS->LV;Ontology_term=ECO:0000305;evidence=ECO:0000305	
O75386	UniProtKB	Sequence conflict	219	226	.	.	.	Note=PTYYMYLE->SHLLYVLG;Ontology_term=ECO:0000305;evidence=ECO:0000305	
O75386	UniProtKB	Sequence conflict	393	393	.	.	.	Note=I->L;Ontology_term=ECO:0000305;evidence=ECO:0000305	
O75386	UniProtKB	Sequence conflict	429	431	.	.	.	Note=GIG->AIS;Ontology_term=ECO:0000305;evidence=ECO:0000305