Reviewed, UniProtKB/Swiss-Prot O75386 (TULP3_HUMAN)

Names and origin

Protein names

Recommended name:
    Tubby-related protein 3
Alternative name(s):
    Tubby-like protein 3

Gene names

Name:	TULP3
Synonyms:	TUBL3

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	442 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Tissue specificity	Expressed at high levels in testis, ovaries, thyroid, and spinal chord.
Sequence similarities	Belongs to the TUB family.

Ontologies

Gene Ontology (GO)
Biological process	G-protein coupled receptor protein signaling pathway Non-traceable author statement. Source: UniProtKB regulation of transcription, DNA-dependent Non-traceable author statement. Source: UniProtKB
Cellular component	nucleus Non-traceable author statement. Source: UniProtKB plasma membrane Non-traceable author statement. Source: UniProtKB
Molecular function	phosphatidylinositol-4,5-bisphosphate binding Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 442	442	Tubby-related protein 3		PRO_0000186470
Experimental info
	Sequence conflict	168 – 181	14	TSGSA…PADNL → IPVLLLPPNQLITF Ref.1
	Sequence conflict	187	1	D → Y in AAH32587. Ref.2
	Sequence conflict	193 – 194	2	YS → LV in AAC95431. Ref.1
	Sequence conflict	219 – 226	8	PTYYMYLE → SHLLYVLG in AAC95431. Ref.1
	Sequence conflict	393	1	I → L in AAC95431. Ref.1
	Sequence conflict	429 – 431	3	GIG → AIS in AAC95431. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	O75386-1 [UniParc]. Last modified February 6, 2007. Version 2. Checksum: 13DBC83305BFAC1D	FASTA	442	49,642
	10 20 30 40 50 60 MEASRCRLSP SGDSVFHEEM MKMRQAKLDY QRLLLEKRQR KKRLEPFMVQ PNPEARLRRA 70 80 90 100 110 120 KPRASDEQTP LVNCHTPHSN VILHGIDGPA AVLKPDEVHA PSVSSSVVEE DAENTVDTAS 130 140 150 160 170 180 KPGLQERLQK HDISESVNFD EETDGISQSA CLERPNSASS QNSTDTGTSG SATAAQPADN 190 200 210 220 230 240 LLGDIDDLED FVYSPAPQGV TVRCRIIRDK RGMDRGLFPT YYMYLEKEEN QKIFLLAARK 250 260 270 280 290 300 RKKSKTANYL ISIDPVDLSR EGESYVGKLR SNLMGTKFTV YDRGICPMKG RGLVGAAHTR 310 320 330 340 350 360 QELAAISYET NVLGFKGPRK MSVIIPGMTL NHKQIPYQPQ NNHDSLLSRW QNRTMENLVE 370 380 390 400 410 420 LHNKAPVWNS DTQSYVLNFR GRVTQASVKN FQIVHKNDPD YIVMQFGRVA DDVFTLDYNY 430 440 PLCAVQAFGI GLSSFDSKLA CE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular characterization of a novel tubby gene family member, TULP3, in mouse and humans." Nishina P.M., North M.A., Ikeda A., Yan Y., Naggert J.K. Genomics 54:215-220(1998) [PubMed: 9828123] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF045583 mRNA. Translation: AAC95431.1. BC032587 mRNA. Translation: AAH32587.1.
IPI	IPI00025353.
RefSeq	NP_003315.2.
UniGene	Hs.655333
3D structure databases
HSSP	HSSP built from PDB template 1I7E based on UniProtKB P50586.
ModBase	Search...
PTM databases
PhosphoSite	O75386.
Proteomic databases
PRIDE	O75386.
Genome annotation databases
Ensembl	ENSG00000078246. Homo sapiens. [Contig view]
GeneID	7289.
KEGG	hsa:7289.
Organism-specific databases
GeneCards	GC12P002870.
HGNC	HGNC:12425. TULP3.
HPA	HPA015285.
MIM	604730. gene.
PharmGKB	PA37087.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	O75386.
OMA	O75386. YYMHLEK.
Gene expression databases
ArrayExpress	O75386.
Bgee	O75386.
CleanEx	HS_TULP3.
GermOnline	ENSG00000078246. Homo sapiens.
Family and domain databases
InterPro	IPR000007. Tubby_C. IPR018066. Tubby_C_CS. IPR005398. Tubby_N. [Graphical view]
Gene3D	G3DSA:3.20.90.10. Tubby_C. 1 hit.
Pfam	PF01167. Tub. 1 hit. [Graphical view]
PRINTS	PR01573. SUPERTUBBY. PR01574. TUBBYPROTEIN.
PROSITE	PS01200. TUB_1. 1 hit. PS01201. TUB_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	28499.
SOURCE	Search...

Entry information

Entry name

TULP3_HUMAN

Accession

Primary (citable) accession number: O75386
Secondary accession number(s): Q8N5B0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	February 6, 2007
Last modified:	June 16, 2009
This is version 60 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)