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O75382

- TRIM3_HUMAN

UniProt

O75382 - TRIM3_HUMAN

Protein

Tripartite motif-containing protein 3

Gene

TRIM3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 137 (01 Oct 2014)
      Sequence version 2 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri22 – 6342RING-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri110 – 15142B box-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. protein C-terminus binding Source: ProtInc
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. nervous system development Source: ProtInc
    2. protein transport Source: UniProtKB-KW

    Keywords - Biological processi

    Protein transport, Transport

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tripartite motif-containing protein 3
    Alternative name(s):
    Brain-expressed RING finger protein
    RING finger protein 22
    RING finger protein 97
    Gene namesi
    Name:TRIM3
    Synonyms:BERP, RNF22, RNF97
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:10064. TRIM3.

    Subcellular locationi

    Cytoplasm By similarity. Early endosome 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: ProtInc
    2. early endosome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Endosome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35534.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 744743Tripartite motif-containing protein 3PRO_0000056197Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication
    Modified residuei7 – 71PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiO75382.
    PaxDbiO75382.
    PRIDEiO75382.

    PTM databases

    PhosphoSiteiO75382.

    Expressioni

    Tissue specificityi

    Expressed in brain, heart, uterus and testis.

    Gene expression databases

    ArrayExpressiO75382.
    BgeeiO75382.
    CleanExiHS_TRIM3.
    GenevestigatoriO75382.

    Organism-specific databases

    HPAiHPA043396.
    HPA048233.

    Interactioni

    Subunit structurei

    Associates with myosin-Vb (MYO5B) and alpha-actinin-4 (ACTN4) By similarity. Component of the CART complex, at least composed of ACTN4, HGS/HRS, MYO5B and TRIM3. Interacts with ZFYVE28/LST2.By similarity2 Publications

    Protein-protein interaction databases

    BioGridi115858. 10 interactions.
    IntActiO75382. 3 interactions.
    STRINGi9606.ENSP00000340797.

    Structurei

    3D structure databases

    ProteinModelPortaliO75382.
    SMRiO75382. Positions 18-63, 290-420, 475-744.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati317 – 418102FilaminAdd
    BLAST
    Repeati473 – 51644NHL 1Add
    BLAST
    Repeati520 – 56344NHL 2Add
    BLAST
    Repeati564 – 60542NHL 3Add
    BLAST
    Repeati609 – 65244NHL 4Add
    BLAST
    Repeati656 – 69944NHL 5Add
    BLAST
    Repeati700 – 74344NHL 6Add
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili153 – 22472Sequence AnalysisAdd
    BLAST

    Domaini

    The interaction with MYO5B is dependent upon its NHL repeats, which form a beta-propeller (NHL) domain containing six blades.By similarity

    Sequence similaritiesi

    Belongs to the TRIM/RBCC family.Curated
    Contains 1 B box-type zinc finger.PROSITE-ProRule annotation
    Contains 1 filamin repeat.PROSITE-ProRule annotation
    Contains 6 NHL repeats.PROSITE-ProRule annotation
    Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri22 – 6342RING-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri110 – 15142B box-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG3391.
    HOGENOMiHOG000220817.
    HOVERGENiHBG054843.
    InParanoidiO75382.
    KOiK11997.
    OMAiINTTAEP.
    OrthoDBiEOG7H4DST.
    PhylomeDBiO75382.
    TreeFamiTF331018.

    Family and domain databases

    Gene3Di2.120.10.30. 1 hit.
    2.60.40.10. 1 hit.
    3.30.40.10. 1 hit.
    4.10.45.10. 1 hit.
    InterProiIPR011042. 6-blade_b-propeller_TolB-like.
    IPR003649. Bbox_C.
    IPR017868. Filamin/ABP280_repeat-like.
    IPR001298. Filamin/ABP280_rpt.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR001258. NHL_repeat.
    IPR013017. NHL_repeat_subgr.
    IPR000315. Znf_B-box.
    IPR018957. Znf_C3HC4_RING-type.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view]
    PfamiPF00630. Filamin. 1 hit.
    PF01436. NHL. 6 hits.
    PF00643. zf-B_box. 1 hit.
    PF00097. zf-C3HC4. 1 hit.
    [Graphical view]
    SMARTiSM00502. BBC. 1 hit.
    SM00336. BBOX. 1 hit.
    SM00557. IG_FLMN. 1 hit.
    SM00184. RING. 1 hit.
    [Graphical view]
    SUPFAMiSSF81296. SSF81296. 1 hit.
    PROSITEiPS50194. FILAMIN_REPEAT. 1 hit.
    PS51125. NHL. 6 hits.
    PS50119. ZF_BBOX. 1 hit.
    PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform Alpha (identifier: O75382-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAKREDSPGP EVQPMDKQFL VCSICLDRYQ CPKVLPCLHT FCERCLQNYI    50
    PAQSLTLSCP VCRQTSILPE QGVSALQNNF FISSLMEAMQ QAPDGAHDPE 100
    DPHPLSVVAG RPLSCPNHEG KTMEFYCEAC ETAMCGECRA GEHREHGTVL 150
    LRDVVEQHKA ALQRQLEAVR GRLPQLSAAI ALVGGISQQL QERKAEALAQ 200
    ISAAFEDLEQ ALQQRKQALV SDLETICGAK QKVLQSQLDT LRQGQEHIGS 250
    SCSFAEQALR LGSAPEVLLV RKHMRERLAA LAAQAFPERP HENAQLELVL 300
    EVDGLRRSVL NLGALLTTSA TAHETVATGE GLRQALVGQP ASLTVTTKDK 350
    DGRLVRTGSA ELRAEITGPD GTRLPVPVVD HKNGTYELVY TARTEGELLL 400
    SVLLYGQPVR GSPFRVRALR PGDLPPSPDD VKRRVKSPGG PGSHVRQKAV 450
    RRPSSMYSTG GKRKDNPIED ELVFRVGSRG REKGEFTNLQ GVSAASSGRI 500
    VVADSNNQCI QVFSNEGQFK FRFGVRGRSP GQLQRPTGVA VDTNGDIIVA 550
    DYDNRWVSIF SPEGKFKTKI GAGRLMGPKG VAVDRNGHII VVDNKSCCVF 600
    TFQPNGKLVG RFGGRGATDR HFAGPHFVAV NNKNEIVVTD FHNHSVKVYS 650
    ADGEFLFKFG SHGEGNGQFN APTGVAVDSN GNIIVADWGN SRIQVFDSSG 700
    SFLSYINTSA EPLYGPQGLA LTSDGHVVVA DAGNHCFKAY RYLQ 744
    Length:744
    Mass (Da):80,830
    Last modified:November 25, 2008 - v2
    Checksum:iFF9829CB52314DD2
    GO
    Isoform Beta (identifier: O75382-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         146-156: Missing.

    Show »
    Length:733
    Mass (Da):79,610
    Checksum:iA31439D4CDEBA6B7
    GO
    Isoform Gamma (identifier: O75382-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         224-302: Missing.

    Show »
    Length:665
    Mass (Da):72,101
    Checksum:i640D87E904DBDA4E
    GO
    Isoform 4 (identifier: O75382-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-119: Missing.
         120-120: G → M

    Note: No experimental confirmation available.

    Show »
    Length:625
    Mass (Da):67,726
    Checksum:i8813BB2C040EB51C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti113 – 1131L → F in AAC24809. (PubMed:11170753)Curated
    Sequence conflicti113 – 1131L → F in AAG53474. (PubMed:11331580)Curated
    Sequence conflicti113 – 1131L → F in AAG53475. (PubMed:11331580)Curated
    Sequence conflicti113 – 1131L → F in AAG53476. (PubMed:11331580)Curated
    Sequence conflicti236 – 2361S → T in AAC24809. (PubMed:11170753)Curated
    Sequence conflicti236 – 2361S → T in AAG53474. (PubMed:11331580)Curated
    Sequence conflicti236 – 2361S → T in AAG53475. (PubMed:11331580)Curated
    Sequence conflicti347 – 3471T → A in AAC24809. (PubMed:11170753)Curated
    Sequence conflicti347 – 3471T → A in AAG53474. (PubMed:11331580)Curated
    Sequence conflicti347 – 3471T → A in AAG53475. (PubMed:11331580)Curated
    Sequence conflicti347 – 3471T → A in AAG53476. (PubMed:11331580)Curated
    Sequence conflicti450 – 4501V → L in BAH12882. (PubMed:14702039)Curated
    Sequence conflicti631 – 6311N → S in AAC24809. (PubMed:11170753)Curated
    Sequence conflicti631 – 6311N → S in AAG53474. (PubMed:11331580)Curated
    Sequence conflicti631 – 6311N → S in AAG53475. (PubMed:11331580)Curated
    Sequence conflicti631 – 6311N → S in AAG53476. (PubMed:11331580)Curated
    Sequence conflicti636 – 6361I → V in AAC24809. (PubMed:11170753)Curated
    Sequence conflicti636 – 6361I → V in AAG53474. (PubMed:11331580)Curated
    Sequence conflicti636 – 6361I → V in AAG53475. (PubMed:11331580)Curated
    Sequence conflicti636 – 6361I → V in AAG53476. (PubMed:11331580)Curated
    Sequence conflicti646 – 6461V → E in AAC24809. (PubMed:11170753)Curated
    Sequence conflicti646 – 6461V → E in AAG53474. (PubMed:11331580)Curated
    Sequence conflicti646 – 6461V → E in AAG53475. (PubMed:11331580)Curated
    Sequence conflicti646 – 6461V → E in AAG53476. (PubMed:11331580)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti298 – 2981L → R.
    Corresponds to variant rs10128723 [ dbSNP | Ensembl ].
    VAR_052124

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 119119Missing in isoform 4. 1 PublicationVSP_044780Add
    BLAST
    Alternative sequencei120 – 1201G → M in isoform 4. 1 PublicationVSP_044781
    Alternative sequencei146 – 15611Missing in isoform Beta. 1 PublicationVSP_005758Add
    BLAST
    Alternative sequencei224 – 30279Missing in isoform Gamma. 1 PublicationVSP_005759Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF045239 mRNA. Translation: AAC24809.1.
    AF220020 mRNA. Translation: AAG53474.1.
    AF220021 mRNA. Translation: AAG53475.1.
    AF220022 mRNA. Translation: AAG53476.1.
    AK291396 mRNA. Translation: BAF84085.1.
    AK298843 mRNA. Translation: BAH12882.1.
    AC084337 Genomic DNA. No translation available.
    CH471064 Genomic DNA. Translation: EAW68709.1.
    BC096827 mRNA. Translation: AAH96827.1.
    CCDSiCCDS58115.1. [O75382-4]
    CCDS7764.1. [O75382-1]
    RefSeqiNP_001234935.1. NM_001248006.1. [O75382-1]
    NP_001234936.1. NM_001248007.1. [O75382-4]
    NP_006449.2. NM_006458.3. [O75382-1]
    NP_150594.2. NM_033278.3. [O75382-1]
    UniGeneiHs.591992.

    Genome annotation databases

    EnsembliENST00000345851; ENSP00000340797; ENSG00000110171. [O75382-1]
    ENST00000359518; ENSP00000352508; ENSG00000110171. [O75382-1]
    ENST00000525074; ENSP00000433102; ENSG00000110171. [O75382-1]
    ENST00000536344; ENSP00000445460; ENSG00000110171. [O75382-4]
    GeneIDi10612.
    KEGGihsa:10612.
    UCSCiuc001mdh.3. human. [O75382-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF045239 mRNA. Translation: AAC24809.1 .
    AF220020 mRNA. Translation: AAG53474.1 .
    AF220021 mRNA. Translation: AAG53475.1 .
    AF220022 mRNA. Translation: AAG53476.1 .
    AK291396 mRNA. Translation: BAF84085.1 .
    AK298843 mRNA. Translation: BAH12882.1 .
    AC084337 Genomic DNA. No translation available.
    CH471064 Genomic DNA. Translation: EAW68709.1 .
    BC096827 mRNA. Translation: AAH96827.1 .
    CCDSi CCDS58115.1. [O75382-4 ]
    CCDS7764.1. [O75382-1 ]
    RefSeqi NP_001234935.1. NM_001248006.1. [O75382-1 ]
    NP_001234936.1. NM_001248007.1. [O75382-4 ]
    NP_006449.2. NM_006458.3. [O75382-1 ]
    NP_150594.2. NM_033278.3. [O75382-1 ]
    UniGenei Hs.591992.

    3D structure databases

    ProteinModelPortali O75382.
    SMRi O75382. Positions 18-63, 290-420, 475-744.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115858. 10 interactions.
    IntActi O75382. 3 interactions.
    STRINGi 9606.ENSP00000340797.

    PTM databases

    PhosphoSitei O75382.

    Proteomic databases

    MaxQBi O75382.
    PaxDbi O75382.
    PRIDEi O75382.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000345851 ; ENSP00000340797 ; ENSG00000110171 . [O75382-1 ]
    ENST00000359518 ; ENSP00000352508 ; ENSG00000110171 . [O75382-1 ]
    ENST00000525074 ; ENSP00000433102 ; ENSG00000110171 . [O75382-1 ]
    ENST00000536344 ; ENSP00000445460 ; ENSG00000110171 . [O75382-4 ]
    GeneIDi 10612.
    KEGGi hsa:10612.
    UCSCi uc001mdh.3. human. [O75382-1 ]

    Organism-specific databases

    CTDi 10612.
    GeneCardsi GC11M006469.
    HGNCi HGNC:10064. TRIM3.
    HPAi HPA043396.
    HPA048233.
    MIMi 605493. gene.
    neXtProti NX_O75382.
    PharmGKBi PA35534.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG3391.
    HOGENOMi HOG000220817.
    HOVERGENi HBG054843.
    InParanoidi O75382.
    KOi K11997.
    OMAi INTTAEP.
    OrthoDBi EOG7H4DST.
    PhylomeDBi O75382.
    TreeFami TF331018.

    Miscellaneous databases

    GeneWikii TRIM3.
    GenomeRNAii 10612.
    NextBioi 40314.
    PROi O75382.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O75382.
    Bgeei O75382.
    CleanExi HS_TRIM3.
    Genevestigatori O75382.

    Family and domain databases

    Gene3Di 2.120.10.30. 1 hit.
    2.60.40.10. 1 hit.
    3.30.40.10. 1 hit.
    4.10.45.10. 1 hit.
    InterProi IPR011042. 6-blade_b-propeller_TolB-like.
    IPR003649. Bbox_C.
    IPR017868. Filamin/ABP280_repeat-like.
    IPR001298. Filamin/ABP280_rpt.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR001258. NHL_repeat.
    IPR013017. NHL_repeat_subgr.
    IPR000315. Znf_B-box.
    IPR018957. Znf_C3HC4_RING-type.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view ]
    Pfami PF00630. Filamin. 1 hit.
    PF01436. NHL. 6 hits.
    PF00643. zf-B_box. 1 hit.
    PF00097. zf-C3HC4. 1 hit.
    [Graphical view ]
    SMARTi SM00502. BBC. 1 hit.
    SM00336. BBOX. 1 hit.
    SM00557. IG_FLMN. 1 hit.
    SM00184. RING. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81296. SSF81296. 1 hit.
    PROSITEi PS50194. FILAMIN_REPEAT. 1 hit.
    PS51125. NHL. 6 hits.
    PS50119. ZF_BBOX. 1 hit.
    PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of a gene (RNF22) encoding a novel brain expressed ring finger protein (BERP) that maps to human chromosome 11p15.5."
      El-Husseini A.E.-D., Fretier P., Vincent S.R.
      Genomics 71:363-367(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA).
      Tissue: Brain.
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA; BETA AND GAMMA).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS ALPHA AND 4).
      Tissue: Brain.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA).
      Tissue: Cervix.
    7. "CART: an Hrs/actinin-4/BERP/myosin V protein complex required for efficient receptor recycling."
      Yan Q., Sun W., Kujala P., Lotfi Y., Vida T.A., Bean A.J.
      Mol. Biol. Cell 16:2470-2482(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE CART COMPLEX, SUBCELLULAR LOCATION.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    10. "Monoubiquitinylation regulates endosomal localization of Lst2, a negative regulator of EGF receptor signaling."
      Mosesson Y., Chetrit D., Schley L., Berghoff J., Ziv T., Carvalho S., Milanezi F., Admon A., Schmitt F., Ehrlich M., Yarden Y.
      Dev. Cell 16:687-698(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ZFYVE28.

    Entry informationi

    Entry nameiTRIM3_HUMAN
    AccessioniPrimary (citable) accession number: O75382
    Secondary accession number(s): B7Z5E6
    , F5H2Q8, Q4V9L4, Q9C038, Q9C039
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 6, 2002
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 137 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3