O75381 (PEX14_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peroxisomal membrane protein PEX14

Alternative name(s):
PTS1 receptor-docking protein
Peroxin-14
Peroxisomal membrane anchor protein PEX14

Gene names

Name:

PEX14

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	377 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of the peroxisomal translocation machinery with PEX13 and PEX17. Interacts with both the PTS1 and PTS2 receptors. Binds directly to PEX17.
Subunit structure	Interacts with PEX5 and PEX19. Ref.9 Ref.15
Subcellular location	Peroxisome membrane; Peripheral membrane protein; Cytoplasmic side Ref.15.
Involvement in disease	Peroxisome biogenesis disorder complementation group K (PBD-CGK) [MIM:614887]: A peroxisomal disorder arising from a failure of protein import into the peroxisomal membrane or matrix. The peroxisome biogenesis disorders (PBD group) are genetically heterogeneous with at least 14 distinct genetic groups as concluded from complementation studies. Include disorders are: Zellweger syndrome (ZWS), neonatal adrenoleukodystrophy (NALD), infantile Refsum disease (IRD), and classical rhizomelic chondrodysplasia punctata (RCDP). ZWS, NALD and IRD are distinct from RCDP and constitute a clinical continuum of overlapping phenotypes known as the Zellweger spectrum (PBD-ZSS). Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.10 Peroxisome biogenesis disorder 13A (PBD13A) [MIM:614887]: A fatal peroxisome biogenesis disorder belonging to the Zellweger disease spectrum and clinically characterized by severe neurologic dysfunction with profound psychomotor retardation, severe hypotonia and neonatal seizures, craniofacial abnormalities, liver dysfunction, and biochemically by the absence of peroxisomes. Additional features include cardiovascular and skeletal defects, renal cysts, ocular abnormalities, and hearing impairment. Most severely affected individuals with the classic form of the disease (classic Zellweger syndrome) die within the first year of life. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.10
Sequence similarities	Belongs to the peroxin-14 family.

Ontologies

Keywords
Biological process	Protein transport Translocation Transport
Cellular component	Membrane Peroxisome
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Peroxisome biogenesis disorder Zellweger syndrome
PTM	Acetylation Phosphoprotein
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	microtubule anchoring Inferred from direct assay PubMed 21525035. Source: UniProtKB negative regulation of protein binding Inferred from direct assay PubMed 21976670. Source: UniProtKB negative regulation of protein homotetramerization Inferred from direct assay PubMed 21976670. Source: UniProtKB negative regulation of sequence-specific DNA binding transcription factor activity Inferred from direct assay PubMed 11863372. Source: UniProtKB negative regulation of transcription, DNA-dependent Inferred from direct assay PubMed 11863372. Source: UniProtKB peroxisome transport along microtubule Inferred from direct assay PubMed 21525035. Source: UniProtKB protein homooligomerization Inferred from direct assay PubMed 12488033. Source: UniProtKB protein import into peroxisome matrix, substrate release Inferred from direct assay PubMed 21976670. Source: UniProtKB protein import into peroxisome matrix, translocation Inferred from direct assay PubMed 21525035. Source: UniProtKB
Cellular_component	integral to membrane Inferred from sequence or structural similarity. Source: UniProtKB nucleus Non-traceable author statement PubMed 11863372. Source: UniProtKB peroxisomal membrane Inferred from direct assay PubMed 10022913PubMed 11669066PubMed 18346465PubMed 21525035. Source: UniProtKB protein complex Inferred from direct assay PubMed 19584060. Source: UniProtKB
Molecular_function	microtubule binding Inferred from direct assay PubMed 21525035. Source: UniProtKB transcription corepressor activity Inferred from direct assay PubMed 11863372. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
PEX19	P40855	4	EBI-594898,EBI-594747

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O75381-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O75381-2)

The sequence of this isoform differs from the canonical sequence as follows:
     58-100: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

1

1

Removed Ref.8

Chain

2 – 377

376

Peroxisomal membrane protein PEX14

PRO_0000058325

Amino acid modifications

Modified residue

2

1

N-acetylalanine Ref.8

Modified residue

34

1

N6-acetyllysine Ref.12

Modified residue

335

1

Phosphoserine Ref.11

Natural variations

Alternative sequence

58 – 100

43

Missing in isoform 2.

VSP_037021

Natural variant

117

1

A → S.
Corresponds to variant rs12061667 [ dbSNP | Ensembl ].

VAR_051269

Natural variant

150

1

A → S.
Corresponds to variant rs11539793 [ dbSNP | Ensembl ].

VAR_051270

Natural variant

320

1

R → K.
Corresponds to variant rs12070353 [ dbSNP | Ensembl ].

VAR_051271

Experimental info

Mutagenesis

52

1

F → A or W: Reduced interaction with PEX19, minor effect on interaction with PEX5. Ref.15

Mutagenesis

56

1

K → A or E: Reduced interaction with PEX19, minor effect on interaction with PEX5. Ref.15

Sequence conflict

319

1

K → E in BAG51028. Ref.3

Secondary structure

1

.

.

.

.

.

.

.

.

.

377

Helix Strand Turn

Details...

Helix

26 – 36

11

Helix

41 – 43

3

Helix

46 – 55

10

Helix

60 – 70

11

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: FED28F62A0B94E7F	FASTA	377	41,237
	10 20 30 40 50 60 MASSEQAEQP SQPSSTPGSE NVLPREPLIA TAVKFLQNSR VRQSPLATRR AFLKKKGLTD 70 80 90 100 110 120 EEIDMAFQQS GTAADEPSSL GPATQVVPVQ PPHLISQPYS PAGSRWRDYG ALAIIMAGIA 130 140 150 160 170 180 FGFHQLYKKY LLPLILGGRE DRKQLERMEA GLSELSGSVA QTVTQLQTTL ASVQELLIQQ 190 200 210 220 230 240 QQKIQELAHE LAAAKATTST NWILESQNIN ELKSEINSLK GLLLNRRQFP PSPSAPKIPS 250 260 270 280 290 300 WQIPVKSPSP SSPAAVNHHS SSDISPVSNE STSSSPGKEG HSPEGSTVTY HLLGPQEEGE 310 320 330 340 350 360 GVVDVKGQVR MEVQGEEEKR EDKEDEEDEE DDDVSHVDEE DCLGVQREDR RGGDGQINEQ 370 VEKLRRPEGA SNESERD
	Isoform 2 [UniParc]. Checksum: 03B5FAF2B7892357	FASTA	334	36,702
	10 20 30 40 50 60 MASSEQAEQP SQPSSTPGSE NVLPREPLIA TAVKFLQNSR VRQSPLATRR AFLKKKGPAG 70 80 90 100 110 120 SRWRDYGALA IIMAGIAFGF HQLYKKYLLP LILGGREDRK QLERMEAGLS ELSGSVAQTV 130 140 150 160 170 180 TQLQTTLASV QELLIQQQQK IQELAHELAA AKATTSTNWI LESQNINELK SEINSLKGLL 190 200 210 220 230 240 LNRRQFPPSP SAPKIPSWQI PVKSPSPSSP AAVNHHSSSD ISPVSNESTS SSPGKEGHSP 250 260 270 280 290 300 EGSTVTYHLL GPQEEGEGVV DVKGQVRMEV QGEEEKREDK EDEEDEEDDD VSHVDEEDCL 310 320 330 GVQREDRRGG DGQINEQVEK LRRPEGASNE SERD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a human PTS1 receptor docking protein directly required for peroxisomal protein import." Fransen M., Terlecky S.R., Subramani S. Proc. Natl. Acad. Sci. U.S.A. 95:8087-8092(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"The peroxin Pex14p. cDNA cloning by functional complementation on a Chinese hamster ovary cell mutant, characterization, and functional analysis." Shimizu N., Itoh R., Hirono Y., Otera H., Ghaedi K., Tateishi K., Tamura S., Okumoto K., Harano T., Mukai S., Fujiki Y. J. Biol. Chem. 274:12593-12604(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Brain, Cerebellum and Placenta.
[4]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[5]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Muscle.
[8]	Bienvenut W.V., Lempens A., Norman J.C. Submitted (OCT-2009) to UniProtKB Cited for: PROTEIN SEQUENCE OF 2-34; 184-195 AND 352-363, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, MASS SPECTROMETRY. Tissue: Ovarian carcinoma.
[9]	"PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis." Sacksteder K.A., Jones J.M., South S.T., Li X., Liu Y., Gould S.J. J. Cell Biol. 148:931-944(2000) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH PEX19.
[10]	"Identification of a new complementation group of the peroxisome biogenesis disorders and PEX14 as the mutated gene." Shimozawa N., Tsukamoto T., Nagase T., Takemoto Y., Koyama N., Suzuki Y., Komori M., Osumi T., Jeannette G., Wanders R.J., Kondo N. Hum. Mutat. 23:552-558(2004) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN PBD-CGK AND PBD13A.
[11]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-335, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[12]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-34, MASS SPECTROMETRY.
[13]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[14]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[15]	"Structural basis for competitive interactions of Pex14 with the import receptors Pex5 and Pex19." Neufeld C., Filipp F.V., Simon B., Neuhaus A., Schueller N., David C., Kooshapur H., Madl T., Erdmann R., Schliebs W., Wilmanns M., Sattler M. EMBO J. 28:745-754(2009) [PubMed] [Europe PMC] [Abstract] Cited for: STRUCTURE BY NMR OF 16-80 IN COMPLEXES WITH PEX5 AND PEX19, MUTAGENESIS OF PHE-52 AND LYS-56, SUBCELLULAR LOCATION, INTERACTION WITH PEX5 AND PEX19.
+	Additional computationally mapped references.

Web resources

GeneReviews

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF045186 mRNA. Translation: AAC39843.1.
AB017546 mRNA. Translation: BAA36837.1.
AK002194 mRNA. Translation: BAG51028.1.
AK293684 mRNA. Translation: BAH11568.1.
AK313046 mRNA. Translation: BAG35878.1.
CR450321 mRNA. Translation: CAG29317.1.
CR542083 mRNA. Translation: CAG46880.1.
AL139423, AL354956, AL591403 Genomic DNA. Translation: CAD20149.2.
AL354956, AL139423, AL591403 Genomic DNA. Translation: CAI19198.1.
AL591403, AL139423, AL354956 Genomic DNA. Translation: CAH70044.1.
CH471130 Genomic DNA. Translation: EAW71661.1.
BC006327 mRNA. Translation: AAH06327.1.

IPI

IPI00025346.
IPI00922479.

RefSeq

NP_004556.1. NM_004565.2.

UniGene

Hs.149983.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2W84	NMR	-	A	16-80	[»]
2W85	NMR	-	A	16-80	[»]

ProteinModelPortal

O75381.

ModBase

Search...

Protein-protein interaction databases

IntAct

O75381. 61 interactions.

MINT

MINT-241450.

STRING

9606.ENSP00000349016.

Protein family/group databases

TCDB

3.A.20.1.1. peroxisomal protein importer (PPI) family.

PTM databases

PhosphoSite

O75381.

Proteomic databases

PaxDb

O75381.

PeptideAtlas

O75381.

PRIDE

O75381.

Protocols and materials databases

DNASU

5195.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000356607; ENSP00000349016; ENSG00000142655.

GeneID

5195.

KEGG

hsa:5195.

UCSC

uc001arn.3. human.
uc010oan.2. human.

Organism-specific databases

CTD

5195.

GeneCards

GC01P010532.

HGNC

HGNC:8856. PEX14.

MIM

601791. gene.
614887. phenotype.

neXtProt

NX_O75381.

Orphanet

772. Infantile Refsum disease.
44. Neonatal adrenoleukodystrophy.
912. Zellweger syndrome.

PharmGKB

PA33198.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG136629.

HOGENOM

HOG000220930.

HOVERGEN

HBG053571.

InParanoid

O75381.

KO

K13343.

OMA

WQIPVKP.

OrthoDB

EOG4BCDNM.

PhylomeDB

O75381.

Gene expression databases

ArrayExpress

O75381.

Bgee

O75381.

CleanEx

HS_PEX14.

Genevestigator

O75381.

Family and domain databases

InterPro

IPR025655. PEX14.
IPR006785. Pex14_N.
[Graphical view]

PANTHER

PTHR23058. PTHR23058. 1 hit.

Pfam

PF04695. Pex14_N. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

PEX14. human.

EvolutionaryTrace

O75381.

GenomeRNAi

5195.

NextBio

20094.

SOURCE

Search...

Entry information

Entry name

PEX14_HUMAN

Accession

Primary (citable) accession number: O75381
Secondary accession number(s): B2R7N1 , B3KML6, B7Z1N2, Q8WX51

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1998
Last modified:	May 1, 2013
This is version 112 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.