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O75381

- PEX14_HUMAN

UniProt

O75381 - PEX14_HUMAN

Protein

Peroxisomal membrane protein PEX14

Gene

PEX14

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Component of the peroxisomal translocation machinery with PEX13 and PEX17. Interacts with both the PTS1 and PTS2 receptors. Binds directly to PEX17.

    GO - Molecular functioni

    1. beta-tubulin binding Source: UniProtKB
    2. microtubule binding Source: UniProtKB
    3. protein binding Source: UniProtKB
    4. protein N-terminus binding Source: UniProtKB
    5. receptor binding Source: UniProtKB
    6. transcription corepressor activity Source: UniProtKB

    GO - Biological processi

    1. microtubule anchoring Source: UniProtKB
    2. negative regulation of protein binding Source: UniProtKB
    3. negative regulation of protein homotetramerization Source: UniProtKB
    4. negative regulation of sequence-specific DNA binding transcription factor activity Source: UniProtKB
    5. negative regulation of transcription, DNA-templated Source: UniProtKB
    6. peroxisome organization Source: UniProtKB
    7. peroxisome transport along microtubule Source: UniProtKB
    8. protein complex assembly Source: UniProtKB
    9. protein homooligomerization Source: UniProtKB
    10. protein import into peroxisome matrix Source: UniProtKB
    11. protein import into peroxisome matrix, substrate release Source: UniProtKB
    12. protein import into peroxisome matrix, translocation Source: UniProtKB

    Keywords - Biological processi

    Protein transport, Translocation, Transport

    Protein family/group databases

    TCDBi3.A.20.1.1. the peroxisomal protein importer (ppi) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peroxisomal membrane protein PEX14
    Alternative name(s):
    PTS1 receptor-docking protein
    Peroxin-14
    Peroxisomal membrane anchor protein PEX14
    Gene namesi
    Name:PEX14
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:8856. PEX14.

    Subcellular locationi

    Peroxisome membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB
    2. intracellular Source: UniProtKB
    3. intracellular membrane-bounded organelle Source: HPA
    4. membrane Source: UniProtKB
    5. nucleolus Source: HPA
    6. nucleus Source: UniProtKB
    7. peroxisomal membrane Source: UniProtKB
    8. peroxisome Source: UniProtKB
    9. protein complex Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Peroxisome

    Pathology & Biotechi

    Involvement in diseasei

    Peroxisome biogenesis disorder complementation group K (PBD-CGK) [MIM:614887]: A peroxisomal disorder arising from a failure of protein import into the peroxisomal membrane or matrix. The peroxisome biogenesis disorders (PBD group) are genetically heterogeneous with at least 14 distinct genetic groups as concluded from complementation studies. Include disorders are: Zellweger syndrome (ZWS), neonatal adrenoleukodystrophy (NALD), infantile Refsum disease (IRD), and classical rhizomelic chondrodysplasia punctata (RCDP). ZWS, NALD and IRD are distinct from RCDP and constitute a clinical continuum of overlapping phenotypes known as the Zellweger spectrum (PBD-ZSS).
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Peroxisome biogenesis disorder 13A (PBD13A) [MIM:614887]: A fatal peroxisome biogenesis disorder belonging to the Zellweger disease spectrum and clinically characterized by severe neurologic dysfunction with profound psychomotor retardation, severe hypotonia and neonatal seizures, craniofacial abnormalities, liver dysfunction, and biochemically by the absence of peroxisomes. Additional features include cardiovascular and skeletal defects, renal cysts, ocular abnormalities, and hearing impairment. Most severely affected individuals with the classic form of the disease (classic Zellweger syndrome) die within the first year of life.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi52 – 521F → A or W: Reduced interaction with PEX19, minor effect on interaction with PEX5. 1 Publication
    Mutagenesisi56 – 561K → A or E: Reduced interaction with PEX19, minor effect on interaction with PEX5. 1 Publication

    Keywords - Diseasei

    Peroxisome biogenesis disorder, Zellweger syndrome

    Organism-specific databases

    MIMi614887. phenotype.
    Orphaneti772. Infantile Refsum disease.
    44. Neonatal adrenoleukodystrophy.
    912. Zellweger syndrome.
    PharmGKBiPA33198.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed3 Publications
    Chaini2 – 377376Peroxisomal membrane protein PEX14PRO_0000058325Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine3 Publications
    Modified residuei34 – 341N6-acetyllysine1 Publication
    Modified residuei335 – 3351Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiO75381.
    PaxDbiO75381.
    PeptideAtlasiO75381.
    PRIDEiO75381.

    PTM databases

    PhosphoSiteiO75381.

    Expressioni

    Gene expression databases

    ArrayExpressiO75381.
    BgeeiO75381.
    CleanExiHS_PEX14.
    GenevestigatoriO75381.

    Organism-specific databases

    HPAiHPA046104.
    HPA049231.

    Interactioni

    Subunit structurei

    Interacts with PEX5 and PEX19.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PEX19P4085515EBI-594898,EBI-594747
    PEX5P5054213EBI-594898,EBI-597835

    Protein-protein interaction databases

    BioGridi111218. 57 interactions.
    IntActiO75381. 62 interactions.
    MINTiMINT-241450.
    STRINGi9606.ENSP00000349016.

    Structurei

    Secondary structure

    1
    377
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi19 – 224
    Helixi26 – 3611
    Helixi41 – 433
    Helixi46 – 5510
    Helixi60 – 7011

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2W84NMR-A16-80[»]
    2W85NMR-A16-80[»]
    4BXUNMR-A16-80[»]
    ProteinModelPortaliO75381.
    SMRiO75381. Positions 20-76.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO75381.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peroxin-14 family.Curated

    Phylogenomic databases

    eggNOGiNOG136629.
    HOGENOMiHOG000220930.
    HOVERGENiHBG053571.
    InParanoidiO75381.
    KOiK13343.
    OMAiWQIPVKP.
    OrthoDBiEOG7DFXD4.
    PhylomeDBiO75381.
    TreeFamiTF323535.

    Family and domain databases

    InterProiIPR025655. PEX14.
    IPR006785. Pex14_N.
    [Graphical view]
    PANTHERiPTHR23058. PTHR23058. 1 hit.
    PfamiPF04695. Pex14_N. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O75381-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MASSEQAEQP SQPSSTPGSE NVLPREPLIA TAVKFLQNSR VRQSPLATRR    50
    AFLKKKGLTD EEIDMAFQQS GTAADEPSSL GPATQVVPVQ PPHLISQPYS 100
    PAGSRWRDYG ALAIIMAGIA FGFHQLYKKY LLPLILGGRE DRKQLERMEA 150
    GLSELSGSVA QTVTQLQTTL ASVQELLIQQ QQKIQELAHE LAAAKATTST 200
    NWILESQNIN ELKSEINSLK GLLLNRRQFP PSPSAPKIPS WQIPVKSPSP 250
    SSPAAVNHHS SSDISPVSNE STSSSPGKEG HSPEGSTVTY HLLGPQEEGE 300
    GVVDVKGQVR MEVQGEEEKR EDKEDEEDEE DDDVSHVDEE DCLGVQREDR 350
    RGGDGQINEQ VEKLRRPEGA SNESERD 377
    Length:377
    Mass (Da):41,237
    Last modified:November 1, 1998 - v1
    Checksum:iFED28F62A0B94E7F
    GO
    Isoform 2 (identifier: O75381-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         58-100: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:334
    Mass (Da):36,702
    Checksum:i03B5FAF2B7892357
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti319 – 3191K → E in BAG51028. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti117 – 1171A → S.
    Corresponds to variant rs12061667 [ dbSNP | Ensembl ].
    VAR_051269
    Natural varianti150 – 1501A → S.
    Corresponds to variant rs11539793 [ dbSNP | Ensembl ].
    VAR_051270
    Natural varianti320 – 3201R → K.
    Corresponds to variant rs12070353 [ dbSNP | Ensembl ].
    VAR_051271

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei58 – 10043Missing in isoform 2. 1 PublicationVSP_037021Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF045186 mRNA. Translation: AAC39843.1.
    AB017546 mRNA. Translation: BAA36837.1.
    AK002194 mRNA. Translation: BAG51028.1.
    AK293684 mRNA. Translation: BAH11568.1.
    AK313046 mRNA. Translation: BAG35878.1.
    CR450321 mRNA. Translation: CAG29317.1.
    CR542083 mRNA. Translation: CAG46880.1.
    AL139423, AL354956, AL591403 Genomic DNA. Translation: CAD20149.2.
    AL354956, AL139423, AL591403 Genomic DNA. Translation: CAI19198.1.
    AL591403, AL139423, AL354956 Genomic DNA. Translation: CAH70044.1.
    CH471130 Genomic DNA. Translation: EAW71661.1.
    BC006327 mRNA. Translation: AAH06327.1.
    CCDSiCCDS30582.1. [O75381-1]
    RefSeqiNP_004556.1. NM_004565.2. [O75381-1]
    UniGeneiHs.149983.

    Genome annotation databases

    EnsembliENST00000356607; ENSP00000349016; ENSG00000142655. [O75381-1]
    GeneIDi5195.
    KEGGihsa:5195.
    UCSCiuc001arn.3. human. [O75381-1]
    uc010oan.2. human. [O75381-2]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF045186 mRNA. Translation: AAC39843.1 .
    AB017546 mRNA. Translation: BAA36837.1 .
    AK002194 mRNA. Translation: BAG51028.1 .
    AK293684 mRNA. Translation: BAH11568.1 .
    AK313046 mRNA. Translation: BAG35878.1 .
    CR450321 mRNA. Translation: CAG29317.1 .
    CR542083 mRNA. Translation: CAG46880.1 .
    AL139423 , AL354956 , AL591403 Genomic DNA. Translation: CAD20149.2 .
    AL354956 , AL139423 , AL591403 Genomic DNA. Translation: CAI19198.1 .
    AL591403 , AL139423 , AL354956 Genomic DNA. Translation: CAH70044.1 .
    CH471130 Genomic DNA. Translation: EAW71661.1 .
    BC006327 mRNA. Translation: AAH06327.1 .
    CCDSi CCDS30582.1. [O75381-1 ]
    RefSeqi NP_004556.1. NM_004565.2. [O75381-1 ]
    UniGenei Hs.149983.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2W84 NMR - A 16-80 [» ]
    2W85 NMR - A 16-80 [» ]
    4BXU NMR - A 16-80 [» ]
    ProteinModelPortali O75381.
    SMRi O75381. Positions 20-76.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111218. 57 interactions.
    IntActi O75381. 62 interactions.
    MINTi MINT-241450.
    STRINGi 9606.ENSP00000349016.

    Protein family/group databases

    TCDBi 3.A.20.1.1. the peroxisomal protein importer (ppi) family.

    PTM databases

    PhosphoSitei O75381.

    Proteomic databases

    MaxQBi O75381.
    PaxDbi O75381.
    PeptideAtlasi O75381.
    PRIDEi O75381.

    Protocols and materials databases

    DNASUi 5195.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000356607 ; ENSP00000349016 ; ENSG00000142655 . [O75381-1 ]
    GeneIDi 5195.
    KEGGi hsa:5195.
    UCSCi uc001arn.3. human. [O75381-1 ]
    uc010oan.2. human. [O75381-2 ]

    Organism-specific databases

    CTDi 5195.
    GeneCardsi GC01P010532.
    GeneReviewsi PEX14.
    HGNCi HGNC:8856. PEX14.
    HPAi HPA046104.
    HPA049231.
    MIMi 601791. gene.
    614887. phenotype.
    neXtProti NX_O75381.
    Orphaneti 772. Infantile Refsum disease.
    44. Neonatal adrenoleukodystrophy.
    912. Zellweger syndrome.
    PharmGKBi PA33198.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG136629.
    HOGENOMi HOG000220930.
    HOVERGENi HBG053571.
    InParanoidi O75381.
    KOi K13343.
    OMAi WQIPVKP.
    OrthoDBi EOG7DFXD4.
    PhylomeDBi O75381.
    TreeFami TF323535.

    Miscellaneous databases

    ChiTaRSi PEX14. human.
    EvolutionaryTracei O75381.
    GeneWikii PEX14.
    GenomeRNAii 5195.
    NextBioi 20094.
    PROi O75381.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O75381.
    Bgeei O75381.
    CleanExi HS_PEX14.
    Genevestigatori O75381.

    Family and domain databases

    InterProi IPR025655. PEX14.
    IPR006785. Pex14_N.
    [Graphical view ]
    PANTHERi PTHR23058. PTHR23058. 1 hit.
    Pfami PF04695. Pex14_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a human PTS1 receptor docking protein directly required for peroxisomal protein import."
      Fransen M., Terlecky S.R., Subramani S.
      Proc. Natl. Acad. Sci. U.S.A. 95:8087-8092(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "The peroxin Pex14p. cDNA cloning by functional complementation on a Chinese hamster ovary cell mutant, characterization, and functional analysis."
      Shimizu N., Itoh R., Hirono Y., Otera H., Ghaedi K., Tateishi K., Tamura S., Okumoto K., Harano T., Mukai S., Fujiki Y.
      J. Biol. Chem. 274:12593-12604(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain, Cerebellum and Placenta.
    4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    5. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Muscle.
    8. Bienvenut W.V., Lempens A., Norman J.C.
      Submitted (OCT-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 2-34; 184-195 AND 352-363, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Ovarian carcinoma.
    9. "PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis."
      Sacksteder K.A., Jones J.M., South S.T., Li X., Liu Y., Gould S.J.
      J. Cell Biol. 148:931-944(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PEX19.
    10. "Identification of a new complementation group of the peroxisome biogenesis disorders and PEX14 as the mutated gene."
      Shimozawa N., Tsukamoto T., Nagase T., Takemoto Y., Koyama N., Suzuki Y., Komori M., Osumi T., Jeannette G., Wanders R.J., Kondo N.
      Hum. Mutat. 23:552-558(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN PBD-CGK AND PBD13A.
    11. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-335, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-34, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    16. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    17. "Structural basis for competitive interactions of Pex14 with the import receptors Pex5 and Pex19."
      Neufeld C., Filipp F.V., Simon B., Neuhaus A., Schueller N., David C., Kooshapur H., Madl T., Erdmann R., Schliebs W., Wilmanns M., Sattler M.
      EMBO J. 28:745-754(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 16-80 IN COMPLEXES WITH PEX5 AND PEX19, MUTAGENESIS OF PHE-52 AND LYS-56, SUBCELLULAR LOCATION, INTERACTION WITH PEX5 AND PEX19.

    Entry informationi

    Entry nameiPEX14_HUMAN
    AccessioniPrimary (citable) accession number: O75381
    Secondary accession number(s): B2R7N1
    , B3KML6, B7Z1N2, Q8WX51
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 125 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3