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O75376

- NCOR1_HUMAN

UniProt

O75376 - NCOR1_HUMAN

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Protein
Nuclear receptor corepressor 1
Gene
NCOR1, KIAA1047
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6.1 Publication

GO - Molecular functioni

  1. RNA polymerase II activating transcription factor binding Source: BHF-UCL
  2. chromatin binding Source: InterPro
  3. histone deacetylase binding Source: BHF-UCL
  4. histone deacetylase regulator activity Source: Ensembl
  5. nuclear hormone receptor binding Source: UniProtKB
  6. protein binding Source: UniProtKB
  7. sequence-specific DNA binding Source: Ensembl
  8. sequence-specific DNA binding transcription factor activity Source: Ensembl
  9. transcription corepressor activity Source: UniProtKB
  10. transcription regulatory region DNA binding Source: BHF-UCL
Complete GO annotation...

GO - Biological processi

  1. CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation Source: Ensembl
  2. Notch signaling pathway Source: Reactome
  3. cellular lipid metabolic process Source: Reactome
  4. cholesterol homeostasis Source: Ensembl
  5. chromatin modification Source: UniProtKB-KW
  6. circadian regulation of gene expression Source: Ensembl
  7. definitive erythrocyte differentiation Source: Ensembl
  8. gene expression Source: Reactome
  9. negative regulation of JNK cascade Source: UniProtKB
  10. negative regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
  11. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  12. positive regulation of histone deacetylation Source: Ensembl
  13. regulation of fatty acid transport Source: BHF-UCL
  14. regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  15. regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  16. regulation of multicellular organism growth Source: Ensembl
  17. small molecule metabolic process Source: Reactome
  18. spindle assembly Source: UniProtKB
  19. thalamus development Source: Ensembl
  20. transcription from RNA polymerase II promoter Source: ProtInc
  21. transcription initiation from RNA polymerase II promoter Source: Reactome
  22. transcription, DNA-templated Source: Reactome
  23. transforming growth factor beta receptor signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_111118. BMAL1:CLOCK,NPAS2 activates circadian gene expression.
REACT_116022. Nuclear signaling by ERBB4.
REACT_116145. PPARA activates gene expression.
REACT_118659. RORA activates circadian gene expression.
REACT_118780. NOTCH1 Intracellular Domain Regulates Transcription.
REACT_118789. REV-ERBA represses gene expression.
REACT_121111. Downregulation of SMAD2/3:SMAD4 transcriptional activity.
REACT_160243. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_160254. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
REACT_19241. Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).
REACT_200608. Transcriptional activation of mitochondrial biogenesis.
REACT_24941. Circadian Clock.
REACT_27161. Transcriptional regulation of white adipocyte differentiation.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor corepressor 1
Short name:
N-CoR
Short name:
N-CoR1
Gene namesi
Name:NCOR1
Synonyms:KIAA1047
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:7672. NCOR1.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nuclear chromatin Source: BHF-UCL
  3. nucleoplasm Source: Reactome
  4. nucleus Source: BHF-UCL
  5. spindle microtubule Source: UniProtKB
  6. transcription factor complex Source: Ensembl
  7. transcriptional repressor complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31477.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 24402440Nuclear receptor corepressor 1
PRO_0000055617Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei224 – 2241Phosphoserine1 Publication
Modified residuei999 – 9991Phosphoserine1 Publication
Modified residuei1111 – 11111Phosphoserine1 Publication
Modified residuei1195 – 11951Phosphoserine1 Publication
Modified residuei1336 – 13361N6-acetyllysine By similarity
Modified residuei1412 – 14121N6-acetyllysine1 Publication
Modified residuei1472 – 14721Phosphoserine6 Publications
Modified residuei1977 – 19771Phosphoserine2 Publications
Modified residuei1981 – 19811Phosphoserine1 Publication
Modified residuei2151 – 21511Phosphoserine3 Publications
Modified residuei2184 – 21841Phosphoserine4 Publications
Modified residuei2399 – 23991Phosphothreonine1 Publication
Modified residuei2436 – 24361Phosphoserine3 Publications
Modified residuei2438 – 24381Phosphoserine3 Publications

Post-translational modificationi

Ubiquitinated; mediated by SIAH2 and leading to its subsequent proteasomal degradation By similarity.

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiO75376.
PaxDbiO75376.
PRIDEiO75376.

PTM databases

PhosphoSiteiO75376.

Expressioni

Gene expression databases

ArrayExpressiO75376.
BgeeiO75376.
CleanExiHS_NCOR1.
GenevestigatoriO75376.

Organism-specific databases

HPAiHPA050288.
HPA051168.

Interactioni

Subunit structurei

Forms a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid receptor (TR) and the retinoid acid receptor (RAR) in the absence of ligand. Interacts directly with RARA; the interaction is facilitated with RARA trimethylation. Component of the N-Cor repressor complex, at least composed of CBFA2T3, HEXIM1, NCOR1, NCOR2, HDAC3, TBL1X, TBL1XR1, CORO2A and GPS2. Interacts with ZBTB33; the interaction serves to recruit the N-CoR complex to promoter regions containing methylated CpG dinucleotides. Interacts with TRIM28 and KDM3A. Interacts (via the RD1 domain) with BAZ1A (via its N-terminal); the interaction corepresses a number of NCOR1-regulated genes. Interacts with BCL6, C1D, DACH1, HEXIM1, HDAC7, RORA, RORC, SAP30, SIAH2, SIN3A and SIN3B. May interact with DEAF1. Interacts with RXRA.13 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
DACH1Q9UI362EBI-347233,EBI-347111
DHX30Q7L2E33EBI-347233,EBI-1211456
HDAC3O153793EBI-347233,EBI-607682
HTTP428583EBI-347233,EBI-466029
NR2E3Q9Y5X42EBI-347233,EBI-7216962
PPARAQ078692EBI-347233,EBI-78615
SKIP127552EBI-347233,EBI-347281
TRIM28Q132634EBI-347233,EBI-78139

Protein-protein interaction databases

BioGridi114973. 142 interactions.
DIPiDIP-29402N.
IntActiO75376. 48 interactions.
MINTiMINT-205170.
STRINGi9606.ENSP00000268712.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi442 – 45413
Helixi459 – 4657
Helixi471 – 48111
Beta strandi2048 – 20503
Helixi2051 – 206313
Helixi2263 – 227210

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2EQRNMR-A433-486[»]
3H52X-ray2.80M/N2258-2276[»]
3KMZX-ray2.10C/D2047-2065[»]
3N00X-ray2.60B2045-2065[»]
4II6X-ray2.90C/D2259-2275[»]
ProteinModelPortaliO75376.
SMRiO75376. Positions 176-216, 433-486, 628-694.

Miscellaneous databases

EvolutionaryTraceiO75376.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini435 – 48652SANT 1
Add
BLAST
Domaini623 – 67452SANT 2
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 373373Interaction with ZBTB33 and HEXIM1
Add
BLAST
Regioni254 – 31259Interaction with SIN3A/B
Add
BLAST
Regioni988 – 1816829Interaction with ETO
Add
BLAST
Regioni1501 – 2440940Interaction with C1D By similarity
Add
BLAST
Regioni2032 – 211584ID1 By similarity
Add
BLAST
Regioni2047 – 20504Required for interaction with RARA in the absence of its ligand By similarity
Regioni2212 – 227362ID2 By similarity
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili174 – 21643 Reviewed prediction
Add
BLAST
Coiled coili299 – 32830 Reviewed prediction
Add
BLAST
Coiled coili501 – 55757 Reviewed prediction
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1933 – 19375CORNR box 1
Motifi2055 – 20595CORNR box 2
Motifi2263 – 22675CORNR box 3

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi58 – 647Poly-Gln
Compositional biasi593 – 60311Poly-Ala
Add
BLAST
Compositional biasi607 – 61711Pro-rich
Add
BLAST
Compositional biasi1032 – 10354Poly-Pro
Compositional biasi1707 – 17126Poly-Ala
Compositional biasi1952 – 196312Poly-Ser
Add
BLAST

Domaini

The N-terminal region contains three independent domains that are capable of mediating transcriptional repression (RD1, RD2 and RD3).
The C-terminal region contains two separate nuclear receptor-interacting domains (ID1 and ID2), each of which contains a conserved sequence referred to as the CORNR box. This motif is necessary and sufficient for binding to unligated nuclear hormone receptors, while sequences flanking the CORNR box determine the precise nuclear hormone receptor specificity By similarity.

Sequence similaritiesi

Contains 2 SANT domains.

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiNOG12793.
HOGENOMiHOG000113746.
HOVERGENiHBG052587.
KOiK04650.
OMAiPIRAFEG.
OrthoDBiEOG75TMB0.
PhylomeDBiO75376.
TreeFamiTF106423.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
[Graphical view]
PfamiPF00249. Myb_DNA-binding. 1 hit.
[Graphical view]
SMARTiSM00717. SANT. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS51293. SANT. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O75376-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSSSGYPPNQ GAFSTEQSRY PPHSVQYTFP NTRHQQEFAV PDYRSSHLEV     50
SQASQLLQQQ QQQQLRRRPS LLSEFHPGSD RPQERRTSYE PFHPGPSPVD 100
HDSLESKRPR LEQVSDSHFQ RVSAAVLPLV HPLPEGLRAS ADAKKDPAFG 150
GKHEAPSSPI SGQPCGDDQN ASPSKLSKEE LIQSMDRVDR EIAKVEQQIL 200
KLKKKQQQLE EEAAKPPEPE KPVSPPPVEQ KHRSIVQIIY DENRKKAEEA 250
HKIFEGLGPK VELPLYNQPS DTKVYHENIK TNQVMRKKLI LFFKRRNHAR 300
KQREQKICQR YDQLMEAWEK KVDRIENNPR RKAKESKTRE YYEKQFPEIR 350
KQREQQERFQ RVGQRGAGLS ATIARSEHEI SEIIDGLSEQ ENNEKQMRQL 400
SVIPPMMFDA EQRRVKFINM NGLMEDPMKV YKDRQFMNVW TDHEKEIFKD 450
KFIQHPKNFG LIASYLERKS VPDCVLYYYL TKKNENYKAL VRRNYGKRRG 500
RNQQIARPSQ EEKVEEKEED KAEKTEKKEE EKKDEEEKDE KEDSKENTKE 550
KDKIDGTAEE TEEREQATPR GRKTANSQGR RKGRITRSMT NEAAAASAAA 600
AAATEEPPPP LPPPPEPIST EPVETSRWTE EEMEVAKKGL VEHGRNWAAI 650
AKMVGTKSEA QCKNFYFNYK RRHNLDNLLQ QHKQKTSRKP REERDVSQCE 700
SVASTVSAQE DEDIEASNEE ENPEDSEVEA VKPSEDSPEN ATSRGNTEPA 750
VELEPTTETA PSTSPSLAVP STKPAEDESV ETQVNDSISA ETAEQMDVDQ 800
QEHSAEEGSV CDPPPATKAD SVDVEVRVPE NHASKVEGDN TKERDLDRAS 850
EKVEPRDEDL VVAQQINAQR PEPQSDNDSS ATCSADEDVD GEPERQRMFP 900
MDSKPSLLNP TGSILVSSPL KPNPLDLPQL QHRAAVIPPM VSCTPCNIPI 950
GTPVSGYALY QRHIKAMHES ALLEEQRQRQ EQIDLECRSS TSPCGTSKSP 1000
NREWEVLQPA PHQVITNLPE GVRLPTTRPT RPPPPLIPSS KTTVASEKPS 1050
FIMGGSISQG TPGTYLTSHN QASYTQETPK PSVGSISLGL PRQQESAKSA 1100
TLPYIKQEEF SPRSQNSQPE GLLVRAQHEG VVRGTAGAIQ EGSITRGTPT 1150
SKISVESIPS LRGSITQGTP ALPQTGIPTE ALVKGSISRM PIEDSSPEKG 1200
REEAASKGHV IYEGKSGHIL SYDNIKNARE GTRSPRTAHE ISLKRSYESV 1250
EGNIKQGMSM RESPVSAPLE GLICRALPRG SPHSDLKERT VLSGSIMQGT 1300
PRATTESFED GLKYPKQIKR ESPPIRAFEG AITKGKPYDG ITTIKEMGRS 1350
IHEIPRQDIL TQESRKTPEV VQSTRPIIEG SISQGTPIKF DNNSGQSAIK 1400
HNVKSLITGP SKLSRGMPPL EIVPENIKVV ERGKYEDVKA GETVRSRHTS 1450
VVSSGPSVLR STLHEAPKAQ LSPGIYDDTS ARRTPVSYQN TMSRGSPMMN 1500
RTSDVTISSN KSTNHERKST LTPTQRESIP AKSPVPGVDP VVSHSPFDPH 1550
HRGSTAGEVY RSHLPTHLDP AMPFHRALDP AAAAYLFQRQ LSPTPGYPSQ 1600
YQLYAMENTR QTILNDYITS QQMQVNLRPD VARGLSPREQ PLGLPYPATR 1650
GIIDLTNMPP TILVPHPGGT STPPMDRITY IPGTQITFPP RPYNSASMSP 1700
GHPTHLAAAA SAERERERER EKERERERIA AASSDLYLRP GSEQPGRPGS 1750
HGYVRSPSPS VRTQETMLQQ RPSVFQGTNG TSVITPLDPT AQLRIMPLPA 1800
GGPSISQGLP ASRYNTAADA LAALVDAAAS APQMDVSKTK ESKHEAARLE 1850
ENLRSRSAAV SEQQQLEQKT LEVEKRSVQC LYTSSAFPSG KPQPHSSVVY 1900
SEAGKDKGPP PKSRYEEELR TRGKTTITAA NFIDVIITRQ IASDKDARER 1950
GSQSSDSSSS LSSHRYETPS DAIEVISPAS SPAPPQEKLQ TYQPEVVKAN 2000
QAENDPTRQY EGPLHHYRPQ QESPSPQQQL PPSSQAEGMG QVPRTHRLIT 2050
LADHICQIIT QDFARNQVSS QTPQQPPTST FQNSPSALVS TPVRTKTSNR 2100
YSPESQAQSV HHQRPGSRVS PENLVDKSRG SRPGKSPERS HVSSEPYEPI 2150
SPPQVPVVHE KQDSLLLLSQ RGAEPAEQRN DARSPGSISY LPSFFTKLEN 2200
TSPMVKSKKQ EIFRKLNSSG GGDSDMAAAQ PGTEIFNLPA VTTSGSVSSR 2250
GHSFADPASN LGLEDIIRKA LMGSFDDKVE DHGVVMSQPM GVVPGTANTS 2300
VVTSGETRRE EGDPSPHSGG VCKPKLISKS NSRKSKSPIP GQGYLGTERP 2350
SSVSSVHSEG DYHRQTPGWA WEDRPSSTGS TQFPYNPLTM RMLSSTPPTP 2400
IACAPSAVNQ AAPHQQNRIW EREPAPLLSA QYETLSDSDD 2440
Length:2,440
Mass (Da):270,210
Last modified:May 10, 2004 - v2
Checksum:i1647FE060373A125
GO
Isoform 2 (identifier: O75376-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     727-727: E → EGAENSSDTESAPSPSP
     1842-1961: SKHEAARLEE...SQSSDSSSSL → I

Show »
Length:2,337
Mass (Da):258,602
Checksum:i6837EA3886E1E03C
GO
Isoform 3 (identifier: O75376-3) [UniParc]FASTAAdd to Basket

Also known as: b

The sequence of this isoform differs from the canonical sequence as follows:
     37-145: Missing.
     727-727: E → EGAENSSDTESAPSPSP
     1006-1007: VL → GR
     1008-2440: Missing.

Note: No experimental confirmation available.

Show »
Length:914
Mass (Da):103,919
Checksum:i8210E2A279ACD8A8
GO

Sequence cautioni

The sequence BAA82999.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei37 – 145109Missing in isoform 3.
VSP_046468Add
BLAST
Alternative sequencei727 – 7271E → EGAENSSDTESAPSPSP in isoform 2 and isoform 3.
VSP_010207
Alternative sequencei1006 – 10072VL → GR in isoform 3.
VSP_046469
Alternative sequencei1008 – 24401433Missing in isoform 3.
VSP_046470Add
BLAST
Alternative sequencei1842 – 1961120SKHEA…SSSSL → I in isoform 2.
VSP_010208Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti5 – 51G → V in AAO32942. 1 Publication
Sequence conflicti20 – 201Y → S in AAO32942. 1 Publication
Sequence conflicti26 – 261Q → K in AAO32942. 1 Publication
Sequence conflicti31 – 311N → S in AAO32942. 1 Publication
Sequence conflicti33 – 331R → H in AAO32942. 1 Publication
Sequence conflicti392 – 3921N → S in AAO32942. 1 Publication
Sequence conflicti1014 – 10141V → L in AAC33550. 1 Publication
Sequence conflicti1508 – 15092SS → PP in AAC33550. 1 Publication
Sequence conflicti1561 – 15611R → W in AAC33550. 1 Publication
Sequence conflicti1567 – 15671H → Q in AAC33550. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF044209 mRNA. Translation: AAC33550.1.
AF303586 mRNA. Translation: AAO32942.1.
AB028970 mRNA. Translation: BAA82999.2. Different initiation.
AC002553 Genomic DNA. No translation available.
AC005971 Genomic DNA. No translation available.
CH471222 Genomic DNA. Translation: EAX04494.1.
BC167431 mRNA. Translation: AAI67431.1.
AB019524 mRNA. Translation: BAA75814.1.
CCDSiCCDS11175.1. [O75376-1]
CCDS54094.1. [O75376-3]
CCDS54095.1. [O75376-2]
RefSeqiNP_001177367.1. NM_001190438.1. [O75376-3]
NP_001177369.1. NM_001190440.1. [O75376-2]
NP_006302.2. NM_006311.3. [O75376-1]
UniGeneiHs.462323.

Genome annotation databases

EnsembliENST00000268712; ENSP00000268712; ENSG00000141027. [O75376-1]
ENST00000395848; ENSP00000379189; ENSG00000141027. [O75376-3]
ENST00000395851; ENSP00000379192; ENSG00000141027. [O75376-2]
GeneIDi9611.
KEGGihsa:9611.
UCSCiuc002gpn.3. human. [O75376-2]
uc002gpo.3. human. [O75376-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF044209 mRNA. Translation: AAC33550.1 .
AF303586 mRNA. Translation: AAO32942.1 .
AB028970 mRNA. Translation: BAA82999.2 . Different initiation.
AC002553 Genomic DNA. No translation available.
AC005971 Genomic DNA. No translation available.
CH471222 Genomic DNA. Translation: EAX04494.1 .
BC167431 mRNA. Translation: AAI67431.1 .
AB019524 mRNA. Translation: BAA75814.1 .
CCDSi CCDS11175.1. [O75376-1 ]
CCDS54094.1. [O75376-3 ]
CCDS54095.1. [O75376-2 ]
RefSeqi NP_001177367.1. NM_001190438.1. [O75376-3 ]
NP_001177369.1. NM_001190440.1. [O75376-2 ]
NP_006302.2. NM_006311.3. [O75376-1 ]
UniGenei Hs.462323.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2EQR NMR - A 433-486 [» ]
3H52 X-ray 2.80 M/N 2258-2276 [» ]
3KMZ X-ray 2.10 C/D 2047-2065 [» ]
3N00 X-ray 2.60 B 2045-2065 [» ]
4II6 X-ray 2.90 C/D 2259-2275 [» ]
ProteinModelPortali O75376.
SMRi O75376. Positions 176-216, 433-486, 628-694.
ModBasei Search...

Protein-protein interaction databases

BioGridi 114973. 142 interactions.
DIPi DIP-29402N.
IntActi O75376. 48 interactions.
MINTi MINT-205170.
STRINGi 9606.ENSP00000268712.

Chemistry

ChEMBLi CHEMBL3038484.

PTM databases

PhosphoSitei O75376.

Proteomic databases

MaxQBi O75376.
PaxDbi O75376.
PRIDEi O75376.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000268712 ; ENSP00000268712 ; ENSG00000141027 . [O75376-1 ]
ENST00000395848 ; ENSP00000379189 ; ENSG00000141027 . [O75376-3 ]
ENST00000395851 ; ENSP00000379192 ; ENSG00000141027 . [O75376-2 ]
GeneIDi 9611.
KEGGi hsa:9611.
UCSCi uc002gpn.3. human. [O75376-2 ]
uc002gpo.3. human. [O75376-1 ]

Organism-specific databases

CTDi 9611.
GeneCardsi GC17M015933.
HGNCi HGNC:7672. NCOR1.
HPAi HPA050288.
HPA051168.
MIMi 600849. gene.
neXtProti NX_O75376.
PharmGKBi PA31477.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG12793.
HOGENOMi HOG000113746.
HOVERGENi HBG052587.
KOi K04650.
OMAi PIRAFEG.
OrthoDBi EOG75TMB0.
PhylomeDBi O75376.
TreeFami TF106423.

Enzyme and pathway databases

Reactomei REACT_111118. BMAL1:CLOCK,NPAS2 activates circadian gene expression.
REACT_116022. Nuclear signaling by ERBB4.
REACT_116145. PPARA activates gene expression.
REACT_118659. RORA activates circadian gene expression.
REACT_118780. NOTCH1 Intracellular Domain Regulates Transcription.
REACT_118789. REV-ERBA represses gene expression.
REACT_121111. Downregulation of SMAD2/3:SMAD4 transcriptional activity.
REACT_160243. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_160254. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
REACT_19241. Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).
REACT_200608. Transcriptional activation of mitochondrial biogenesis.
REACT_24941. Circadian Clock.
REACT_27161. Transcriptional regulation of white adipocyte differentiation.

Miscellaneous databases

ChiTaRSi NCOR1. human.
EvolutionaryTracei O75376.
GeneWikii Nuclear_receptor_co-repressor_1.
GenomeRNAii 9611.
NextBioi 36055.
PROi O75376.
SOURCEi Search...

Gene expression databases

ArrayExpressi O75376.
Bgeei O75376.
CleanExi HS_NCOR1.
Genevestigatori O75376.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR009057. Homeodomain-like.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
[Graphical view ]
Pfami PF00249. Myb_DNA-binding. 1 hit.
[Graphical view ]
SMARTi SM00717. SANT. 2 hits.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 2 hits.
PROSITEi PS51293. SANT. 2 hits.
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Publicationsi

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  1. "ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex."
    Wang J., Hoshino T., Redner R.L., Kajigaya S., Liu J.M.
    Proc. Natl. Acad. Sci. U.S.A. 95:10860-10865(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Fetal brain.
  2. Yu L.
    Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
  3. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  4. Ohara O., Nagase T., Kikuno R.
    Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  5. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  8. "Localization of the human nuclear receptor co-repressor (hN-CoR) gene between the CMT1A and the SMS critical regions of chromosome 17p11.2."
    Nagaya T., Chen K.-S., Fujieda M., Ohmori S., Richer J.K., Horwitz K.B., Lupski J.R., Seo H.
    Genomics 59:339-341(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 974-2440 (ISOFORM 1).
  9. "Transcriptional activation and repression by RORalpha, an orphan nuclear receptor required for cerebellar development."
    Harding H.P., Atkins G.B., Jaffe A.B., Seo W.J., Lazar M.A.
    Mol. Endocrinol. 11:1737-1746(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RORA.
  10. "A novel nuclear receptor corepressor complex, N-CoR, contains components of the mammalian SWI/SNF complex and the corepressor KAP-1."
    Underhill C., Qutob M.S., Yee S.P., Torchia J.
    J. Biol. Chem. 275:40463-40470(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TRIM28.
  11. "ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain."
    Amann J.M., Nip J., Strom D.K., Lutterbach B., Harada H., Lenny N., Downing J.R., Meyers S., Hiebert S.W.
    Mol. Cell. Biol. 21:6470-6483(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CBFA2T3.
  12. "The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2."
    Zhang J., Kalkum M., Chait B.T., Roeder R.G.
    Mol. Cell 9:611-623(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: COMPONENT OF THE N-COR COMPLEX WITH TBL1X; TBL1R; NCOR2; GPS2 AND HDAC3.
  13. "The histone deacetylase 9 gene encodes multiple protein isoforms."
    Petrie K., Guidez F., Howell L., Healy L., Waxman S., Greaves M., Zelent A.
    J. Biol. Chem. 278:16059-16072(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HDAC9.
  14. Cited for: INTERACTION WITH DACH1.
  15. "N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso."
    Yoon H.-G., Chan D.W., Reynolds A.B., Qin J., Wong J.
    Mol. Cell 12:723-734(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CORO2A; GPS2; HDAC3; TBL1R; TBL1X AND ZBTB33.
  16. "MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation."
    Fujita N., Jaye D.L., Geigerman C., Akyildiz A., Mooney M.R., Boss J.M., Wade P.A.
    Cell 119:75-86(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH BCL6.
  17. "JMJD2A is a novel N-CoR-interacting protein and is involved in repression of the human transcription factor achaete scute-like homologue 2 (ASCL2/Hash2)."
    Zhang D., Yoon H.-G., Wong J.
    Mol. Cell. Biol. 25:6404-6414(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH KDM3A.
  18. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-224; SER-999 AND SER-2151, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  19. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2184, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  20. "Regulation of P-TEFb elongation complex activity by CDK9 acetylation."
    Fu J., Yoon H.-G., Qin J., Wong J.
    Mol. Cell. Biol. 27:4641-4651(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HEXIM1.
  21. "Novel regulatory role for human Acf1 in transcriptional repression of vitamin D3 receptor-regulated genes."
    Ewing A.K., Attner M., Chakravarti D.
    Mol. Endocrinol. 21:1791-1806(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH BAZ1A.
  22. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1472, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  23. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1472, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  24. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1111; SER-1472; SER-1977; SER-1981; SER-2184; THR-2399; SER-2436 AND SER-2438, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  25. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  26. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1472; SER-1977; SER-2151; SER-2184 AND SER-2436, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  27. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1412, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  28. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1472; SER-2184 AND SER-2438, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  29. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  30. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1195; SER-1472; SER-2151; SER-2436 AND SER-2438, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  31. Cited for: INTERACTION WITH BCL6.
  32. Cited for: INTERACTION WITH DEAF1.
  33. "Solution structure of the first SANT domain from human nuclear receptor corepressor 1."
    RIKEN structural genomics initiative (RSGI)
    Submitted (APR-2008) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 433-486.
  34. "A unique secondary-structure switch controls constitutive gene repression by retinoic acid receptor."
    le Maire A., Teyssier C., Erb C., Grimaldi M., Alvarez S., de Lera A.R., Balaguer P., Gronemeyer H., Royer C.A., Germain P., Bourguet W.
    Nat. Struct. Mol. Biol. 17:801-807(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 2047-2065 IN COMPLEX WITH RARA AND RARA AGONIST BMS493, INTERACTION WITH RARA.

Entry informationi

Entry nameiNCOR1_HUMAN
AccessioniPrimary (citable) accession number: O75376
Secondary accession number(s): B3DLF8
, E9PGV6, Q86YY0, Q9UPV5, Q9UQ18
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 10, 2004
Last modified: September 3, 2014
This is version 155 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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