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Protein

Zinc finger protein 737

Gene

ZNF737

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri173 – 19523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri201 – 22323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri229 – 25123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri257 – 27923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri285 – 30723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri313 – 33523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri341 – 36323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri369 – 39123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri397 – 41923C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri425 – 44723C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri453 – 47523C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri481 – 50323C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri509 – 53123C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 737
Alternative name(s):
Zinc finger protein 102
Gene namesi
Name:ZNF737
Synonyms:ZNF102
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:32468. ZNF737.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiZNF737.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 536536Zinc finger protein 737PRO_0000340686Add
BLAST

Proteomic databases

PaxDbiO75373.
PRIDEiO75373.

PTM databases

iPTMnetiO75373.
PhosphoSiteiO75373.

Expressioni

Gene expression databases

BgeeiO75373.
ExpressionAtlasiO75373. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000395733.

Structurei

3D structure databases

ProteinModelPortaliO75373.
SMRiO75373. Positions 143-535.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 7572KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri173 – 19523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri201 – 22323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri229 – 25123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri257 – 27923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri285 – 30723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri313 – 33523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri341 – 36323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri369 – 39123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri397 – 41923C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri425 – 44723C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri453 – 47523C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri481 – 50323C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri509 – 53123C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000122969.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiO75373.
KOiK09228.
OMAiAFKRSFI.
PhylomeDBiO75373.
TreeFamiTF342117.

Family and domain databases

Gene3Di3.30.160.60. 14 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O75373-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPLQFRDVA IEFSLEEWHC LDTAQRNLYR NVMLENYRNL VFLGIVVSKP
60 70 80 90 100
DLITCLEQGK KPLTMKKHEM VANPSVTCSH FARDLWPEQS IKDSFQKVTL
110 120 130 140 150
RRYENYGHDN LQFKKGCESV DECKVHKRGY NGLNQYLTTT QSKIFQCDKY
160 170 180 190 200
VKVIHKFSNS NRHKIRHTGK KPFKCIECGK AFNQSSTLTT HKKIHTGEKP
210 220 230 240 250
FKCEECGKAF NWSSHLTTHK RIHTGEKRYK CEDCGKAFSR FSYLTAHKII
260 270 280 290 300
HSGEKPYKCE ECGKAFKRSS NLTTHKIIHT GEKPYKCEEC GKAFKRSSIL
310 320 330 340 350
TAHKIIHSGE KPYKCEECGK AFKHPSVLTT HKRIHTGEKP YKCEECGRAF
360 370 380 390 400
KYFSSLTTHK IIHSGEKPYK CEECGKAFNW SSHLTTHKRI HTGEKPYKCE
410 420 430 440 450
ECGEAFKYSS SLTTHKIIHT GQQPFKCEEC GKAFKCFSIL TTHKRIHTGE
460 470 480 490 500
KPYKCEECGK AFNSSSHLTA HKRIHTGEKP YKCERCGKAF KRSFILTRHK
510 520 530
RIHTGEKPYK CEECGKGFKC PSTLTTHKVI HTGEKL
Length:536
Mass (Da):61,931
Last modified:May 16, 2012 - v3
Checksum:i3DC80FAE59F86C00
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti78 – 781C → S.
Corresponds to variant rs7254995 [ dbSNP | Ensembl ].
VAR_067460
Natural varianti125 – 1251V → L.
Corresponds to variant rs9653154 [ dbSNP | Ensembl ].
VAR_067461
Natural varianti492 – 4921R → C.
Corresponds to variant rs10410201 [ dbSNP | Ensembl ].
VAR_067462
Natural varianti516 – 5161K → E.1 Publication
Corresponds to variant rs10411329 [ dbSNP | Ensembl ].
VAR_067463

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008554 Genomic DNA. No translation available.
AC010636 Genomic DNA. No translation available.
BC015765 mRNA. No translation available.
AF044026 Genomic DNA. Translation: AAC25694.1.
CCDSiCCDS54238.1.
RefSeqiNP_001152765.1. NM_001159293.1.
UniGeneiHs.515696.

Genome annotation databases

EnsembliENST00000427401; ENSP00000395733; ENSG00000237440.
GeneIDi100129842.
KEGGihsa:100129842.
UCSCiuc002npa.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008554 Genomic DNA. No translation available.
AC010636 Genomic DNA. No translation available.
BC015765 mRNA. No translation available.
AF044026 Genomic DNA. Translation: AAC25694.1.
CCDSiCCDS54238.1.
RefSeqiNP_001152765.1. NM_001159293.1.
UniGeneiHs.515696.

3D structure databases

ProteinModelPortaliO75373.
SMRiO75373. Positions 143-535.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000395733.

PTM databases

iPTMnetiO75373.
PhosphoSiteiO75373.

Polymorphism and mutation databases

BioMutaiZNF737.

Proteomic databases

PaxDbiO75373.
PRIDEiO75373.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000427401; ENSP00000395733; ENSG00000237440.
GeneIDi100129842.
KEGGihsa:100129842.
UCSCiuc002npa.4. human.

Organism-specific databases

CTDi100129842.
GeneCardsiZNF737.
HGNCiHGNC:32468. ZNF737.
MIMi603984. gene.
neXtProtiNX_O75373.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000122969.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiO75373.
KOiK09228.
OMAiAFKRSFI.
PhylomeDBiO75373.
TreeFamiTF342117.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii100129842.
PROiO75373.
SOURCEiSearch...

Gene expression databases

BgeeiO75373.
ExpressionAtlasiO75373. baseline and differential.

Family and domain databases

Gene3Di3.30.160.60. 14 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLU-516.
  3. "Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells."
    Bellefroid E.J., Marine J.-C., Ried T., Lecocq P.J., Riviere M., Amemiya C.T., Poncelet D.A., Coulie P.G., de Jong P.J., Szpirer C., Ward D.C., Martial J.A.
    EMBO J. 12:1363-1374(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 90-154.

Entry informationi

Entry nameiZN737_HUMAN
AccessioniPrimary (citable) accession number: O75373
Secondary accession number(s): C9JHM3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: May 16, 2012
Last modified: June 8, 2016
This is version 97 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.