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Protein

SH3 domain-binding glutamic acid-rich-like protein

Gene

SH3BGRL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • SH3/SH2 adaptor activity Source: ProtInc
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000131171-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
SH3 domain-binding glutamic acid-rich-like protein
Gene namesi
Name:SH3BGRL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:10823. SH3BGRL.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • extracellular space Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi6451.
OpenTargetsiENSG00000131171.
PharmGKBiPA35731.

Polymorphism and mutation databases

BioMutaiSH3BGRL.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002207451 – 114SH3 domain-binding glutamic acid-rich-like proteinAdd BLAST114

Proteomic databases

EPDiO75368.
PaxDbiO75368.
PeptideAtlasiO75368.
PRIDEiO75368.
TopDownProteomicsiO75368.

2D gel databases

DOSAC-COBS-2DPAGEO75368.
OGPiO75368.
REPRODUCTION-2DPAGEO75368.
SWISS-2DPAGEO75368.

PTM databases

iPTMnetiO75368.
PhosphoSitePlusiO75368.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000131171.
CleanExiHS_SH3BGRL.
ExpressionAtlasiO75368. baseline and differential.
GenevisibleiO75368. HS.

Organism-specific databases

HPAiHPA051248.

Interactioni

GO - Molecular functioni

  • SH3/SH2 adaptor activity Source: ProtInc

Protein-protein interaction databases

BioGridi112349. 15 interactors.
IntActiO75368. 2 interactors.
MINTiMINT-1562247.
STRINGi9606.ENSP00000362308.

Structurei

Secondary structure

1114
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 7Combined sources5
Helixi14 – 29Combined sources16
Beta strandi34 – 38Combined sources5
Helixi43 – 52Combined sources10
Helixi55 – 57Combined sources3
Beta strandi60 – 63Combined sources4
Beta strandi68 – 71Combined sources4
Beta strandi74 – 78Combined sources5
Helixi79 – 87Combined sources9
Helixi91 – 95Combined sources5
Helixi104 – 114Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1U6TX-ray1.90A2-114[»]
1WRYNMR-A1-108[»]
ProteinModelPortaliO75368.
SMRiO75368.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO75368.

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi61 – 67SH3-bindingSequence analysis7

Sequence similaritiesi

Belongs to the SH3BGR family.Curated

Keywords - Domaini

SH3-binding

Phylogenomic databases

eggNOGiKOG4023. Eukaryota.
ENOG4111N7M. LUCA.
GeneTreeiENSGT00440000039098.
HOGENOMiHOG000095212.
HOVERGENiHBG054781.
InParanoidiO75368.
OMAiEEKYCGN.
OrthoDBiEOG091G10PC.
PhylomeDBiO75368.
TreeFamiTF105574.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR006993. Glut_rich_SH3-bd.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF04908. SH3BGR. 1 hit.
[Graphical view]
PIRSFiPIRSF008142. SH3-bind_E-rich_L. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.

Sequencei

Sequence statusi: Complete.

O75368-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVIRVYIASS SGSTAIKKKQ QDVLGFLEAN KIGFEEKDIA ANEENRKWMR
60 70 80 90 100
ENVPENSRPA TGYPLPPQIF NESQYRGDYD AFFEARENNA VYAFLGLTAP
110
PGSKEAEVQA KQQA
Length:114
Mass (Da):12,774
Last modified:November 1, 1998 - v1
Checksum:iD72AC2A095F1AA8B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti35E → K (PubMed:11230166).Curated1
Sequence conflicti35E → K (Ref. 3) Curated1
Sequence conflicti113Q → R (PubMed:11230166).Curated1
Sequence conflicti113Q → R (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF042081 mRNA. Translation: AAC27445.1.
AL136718 mRNA. Translation: CAB66652.1.
CR533478 mRNA. Translation: CAG38509.1.
AL357115 Genomic DNA. Translation: CAI39436.1.
BC016709 mRNA. Translation: AAH16709.1.
BC103762 mRNA. Translation: AAI03763.1.
CCDSiCCDS14449.1.
PIRiJE0178.
RefSeqiNP_003013.1. NM_003022.2.
UniGeneiHs.108029.

Genome annotation databases

EnsembliENST00000373212; ENSP00000362308; ENSG00000131171.
GeneIDi6451.
KEGGihsa:6451.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF042081 mRNA. Translation: AAC27445.1.
AL136718 mRNA. Translation: CAB66652.1.
CR533478 mRNA. Translation: CAG38509.1.
AL357115 Genomic DNA. Translation: CAI39436.1.
BC016709 mRNA. Translation: AAH16709.1.
BC103762 mRNA. Translation: AAI03763.1.
CCDSiCCDS14449.1.
PIRiJE0178.
RefSeqiNP_003013.1. NM_003022.2.
UniGeneiHs.108029.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1U6TX-ray1.90A2-114[»]
1WRYNMR-A1-108[»]
ProteinModelPortaliO75368.
SMRiO75368.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112349. 15 interactors.
IntActiO75368. 2 interactors.
MINTiMINT-1562247.
STRINGi9606.ENSP00000362308.

PTM databases

iPTMnetiO75368.
PhosphoSitePlusiO75368.

Polymorphism and mutation databases

BioMutaiSH3BGRL.

2D gel databases

DOSAC-COBS-2DPAGEO75368.
OGPiO75368.
REPRODUCTION-2DPAGEO75368.
SWISS-2DPAGEO75368.

Proteomic databases

EPDiO75368.
PaxDbiO75368.
PeptideAtlasiO75368.
PRIDEiO75368.
TopDownProteomicsiO75368.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373212; ENSP00000362308; ENSG00000131171.
GeneIDi6451.
KEGGihsa:6451.

Organism-specific databases

CTDi6451.
DisGeNETi6451.
GeneCardsiSH3BGRL.
HGNCiHGNC:10823. SH3BGRL.
HPAiHPA051248.
MIMi300190. gene.
neXtProtiNX_O75368.
OpenTargetsiENSG00000131171.
PharmGKBiPA35731.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4023. Eukaryota.
ENOG4111N7M. LUCA.
GeneTreeiENSGT00440000039098.
HOGENOMiHOG000095212.
HOVERGENiHBG054781.
InParanoidiO75368.
OMAiEEKYCGN.
OrthoDBiEOG091G10PC.
PhylomeDBiO75368.
TreeFamiTF105574.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000131171-MONOMER.

Miscellaneous databases

ChiTaRSiSH3BGRL. human.
EvolutionaryTraceiO75368.
GeneWikiiSH3BGRL.
GenomeRNAii6451.
PROiO75368.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000131171.
CleanExiHS_SH3BGRL.
ExpressionAtlasiO75368. baseline and differential.
GenevisibleiO75368. HS.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR006993. Glut_rich_SH3-bd.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF04908. SH3BGR. 1 hit.
[Graphical view]
PIRSFiPIRSF008142. SH3-bind_E-rich_L. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSH3L1_HUMAN
AccessioniPrimary (citable) accession number: O75368
Secondary accession number(s): Q3SYL1
, Q5JT50, Q6FIE8, Q9H0N8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1998
Last modified: November 2, 2016
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.